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spermatogenesis histone methylation

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https://www.readbyqxmd.com/read/28420800/setdb1-plays-an-essential-role-in-maintenance-of-gonocyte-survival-in-pigs
#1
Tian Tian Liu, Pengfei Zhang, Tian Jiao Li, Xiao Xu Chen, Zhen Shuo Zhu, Ying Hua Lyu, Xue Liang Li, Xiue Tian, Wen Xian Zeng
Histone methyltransferase SETDB1 suppresses gene expression and modulates heterochromatin formation through H3K9me2/3. Previous studies have revealed that SETDB1 catalyzes lysine 9 of histone H3 tri-methylation and plays essential roles in maintaining the survival of embryonic stem cells and spermatogonial stem cells in mice. However, the function of SETDB1 in porcine male germ cells remains unclear. The aim of the present study was to reveal the expression profile and function of SETDB1 in porcine germ cells...
April 18, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28416760/the-histone-demethylase-kdm3a-regulates-the-transcriptional-program-of-the-androgen-receptor-in-prostate-cancer-cells
#2
Stephen Wilson, Lingling Fan, Natasha Sahgal, Jianfei Qi, Fabian V Filipp
The lysine demethylase 3A (KDM3A, JMJD1A or JHDM2A) controls transcriptional networks in a variety of biological processes such as spermatogenesis, metabolism, stem cell activity, and tumor progression. We matched transcriptomic and ChIP-Seq profiles to decipher a genome-wide regulatory network of epigenetic control by KDM3A in prostate cancer cells. ChIP-Seq experiments monitoring histone 3 lysine 9 (H3K9) methylation marks show global histone demethylation effects of KDM3A. Combined assessment of histone demethylation events and gene expression changes presented major transcriptional activation suggesting that distinct oncogenic regulators may synergize with the epigenetic patterns by KDM3A...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28359186/impact-of-lactational-exposure-to-polychlorinated-biphenyl-causes-epigenetic-modification-and-impairs-sertoli-cells-functional-regulators-in-f1-progeny
#3
E Sugantha Priya, T Sathish Kumar, P Raja Singh, S Balakrishnan, J Arunakaran
Polychlorinated biphenyl (PCB) is an endocrine-disrupting chemical. Sertoli cells (SCs) provide physical and nutritional support for developing germ cells. Dysfunction in SCs has adverse effects on spermatogenesis. Previously, we found that the lactational exposure of PCBs (1, 2, and 5 mg/kg birth weight/day, orally from postnatal days 1 to 20) decreased the follicle-stimulating hormone receptor (FSHR) and androgen receptor (AR) expression in SCs of F1 progeny. Transcription factors initiate and regulate the transcription of genes...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28254491/ezh1-in-germ-cells-safeguards-the-function-of-prc2-during-spermatogenesis
#4
Weipeng Mu, Joshua Starmer, Yoichiro Shibata, Della Yee, Terry Magnuson
We previously reported the requirement of Polycomb Repressive Complex 2 (PRC2) for spermatogenesis through transcriptional repression of somatic genes and meiosis-specific genes. To characterize how PRC2's two methyltransferase subunits, EZH1 and EZH2, regulate histone H3 lysine 27 (H3K27) methylation during germ cell development, we generated mouse models with a germline ablation of EZH1 and/or EHZ2. Only the combined loss of EZH1 and EZH2 caused a depletion of global H3K27me3 marks and meiotic arrest in spermatocytes...
April 15, 2017: Developmental Biology
https://www.readbyqxmd.com/read/27857213/the-modification-of-tet1-in-male-germline-stem-cells-and-interact-with-pcna-hdac1-to-promote-their-self-renewal-and-proliferation
#5
Liming Zheng, Yuanxin Zhai, Na Li, Fanglin Ma, Haijing Zhu, Xiaomin Du, Guangpeng Li, Jinlian Hua
Epigenetic modification plays key roles in spermatogenesis, especially DNA methylation dynamic is important in sustaining normal spermatogenesis. Ten-eleven translocation 1 (Tet1) is not only a key demethylase, which works in specific gene regions, but also crosstalks with partners to regulate epigenetic progress as protein complexes. Dairy goat is an important livestock in China, while the unstable culture system in vitro inhibits optimization of new dairy goat species. The study of epigenetic modification in male germline stem cells (mGSCs) is beneficial to the optimization of adult stem cell culture system in vitro, and the improvement of sperm quality and breeding of selected livestock...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818689/epigenetic-remodeling-in-male-germline-development
#6
REVIEW
Na Li, Qiaoyan Shen, Jinlian Hua
In mammals, germ cells guarantee the inheritance of genetic and epigenetic information across generations and are the origin of a new organism. During embryo development, the blastocyst is formed in the early stage, is comprised of an inner cell mass which is pluripotent, and could give rise to the embryonic stem cells (ESCs). The inner cell mass undergoes demethylation processes and will reestablish a methylated state that is similar to that of somatic cells later in epiblast stage. Primordial germ cells (PGCs) will be formed very soon and accompanied by the process of genome-wide demethylation...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27643486/characterization-of-post-translational-modifications-on-lysine-9-of-histone-h3-variants-in-mouse-testis-using-matrix-assisted-laser-desorption-ionization-in-source-decay
#7
Ho-Geun Kwak, Naoshi Dohmae
RATIONALE: Post-translational modifications (PTMs) of histones result in changes to transcriptional activities and chromatin remodeling. Lysine 9 of histone H3 (H3K9) is subject to PTMs, such as methylation and acetylation, which influence histone activity during spermatogenesis. Characterization strategies for studying PTMs on H3K9 have been developed to provide epigenetic and proteomic information. Proteomic analysis has been used to limited success to study PTMs on H3K9; however, a comprehensive analytical approach is required to elucidate global patterns of PTMs of H3 variants during spermatogenesis...
September 19, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27601712/epigenetic-reprogramming-of-the-zygote-in-mice-and-men-on-your-marks-get-set-go
#8
REVIEW
Rupsha Fraser, Chih-Jen Lin
Gametogenesis (spermatogenesis and oogenesis) is accompanied by the acquisition of gender-specific epigenetic marks, such as DNA methylation, histone modifications and regulation by small RNAs, to form highly differentiated, but transcriptionally silent cell-types in preparation for fertilisation. Upon fertilisation, extensive global epigenetic reprogramming takes place to remove the previously acquired epigenetic marks and produce totipotent zygotic states. It is the aim of this review to delineate the cellular and molecular events involved in maternal, paternal and zygotic epigenetic reprogramming from the time of gametogenesis, through fertilisation, to the initiation of zygotic genome activation for preimplantation embryonic development...
December 2016: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27573846/mrg15-is-required-for-pre-mrna-splicing-and-spermatogenesis
#9
Naoki Iwamori, Kaoru Tominaga, Tetsuya Sato, Kevin Riehle, Tokuko Iwamori, Yasuyuki Ohkawa, Cristian Coarfa, Etsuro Ono, Martin M Matzuk
Splicing can be epigenetically regulated and involved in cellular differentiation in somatic cells, but the interplay of epigenetic factors and the splicing machinery during spermatogenesis remains unclear. To study these interactions in vivo, we generated a germline deletion of MORF-related gene on chromosome 15 (MRG15), a multifunctional chromatin organizer that binds to methylated histone H3 lysine 36 (H3K36) in introns of transcriptionally active genes and has been implicated in regulation of histone acetylation, homology-directed DNA repair, and alternative splicing in somatic cells...
September 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27441500/the-cancer-testis-antigen-prame-supports-the-pluripotency-network-and-represses-somatic-and-germ-cell-differentiation-programs-in-seminomas
#10
Daniel Nettersheim, Isabell Arndt, Rakesh Sharma, Stefanie Riesenberg, Sina Jostes, Simon Schneider, Michael Hölzel, Glen Kristiansen, Hubert Schorle
BACKGROUND: Cancer/testis-antigens (CTAs) are specifically expressed in human malignancies and testis tissue, but their molecular functions are poorly understood. CTAs serve as regulators of gene expression, cell cycle and spermatogenesis, as well as targets for immune-based therapies. The CTA PRAME is expressed in various cancers, antagonises retinoic acid signalling and is regulated by DNA methylation and histone acetylation. METHODS: We analysed the molecular function of the CTA PRAME in primordial germ cells (PGC) and testicular germ cell cancers (GCC)...
August 9, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27396502/5-aza-2-deoxycytidine-impairs-mouse-spermatogenesis-at-multiple-stages-through-different-usage-of-dna-methyltransferases
#11
Ning Song, Daisuke Endo, Bin Song, Yasuaki Shibata, Takehiko Koji
Mammalian spermatogenesis is a progressive process comprising spermatogonial proliferation, spermatocytic meiosis, and later spermiogenesis, which is considered to be under the regulation of epigenetic parameters. To gain insights into the significance of DNA methylation in early spermatogenesis, 5-azadC was used as a molecular biological tool to mimic the level of DNA methylation in vivo. Since the drug is incorporated into DNA during the S-phase, spermatogonia and spermatocytes would be affected primarily in mouse spermatogenesis...
June 15, 2016: Toxicology
https://www.readbyqxmd.com/read/26988797/modification-of-tet1-and-histone-methylation-dynamics-in-dairy-goat-male-germline-stem-cells
#12
Liming Zheng, Yuanxin Zhai, Na Li, Chongyang Wu, Haijing Zhu, Zhuying Wei, Chunling Bai, Guangpeng Li, Jinlian Hua
OBJECTIVES: Tet (ten-eleven translocation) protein 1 is a key enzyme for DNA demethylation, which modulates DNA methylation and gene transcription. DNA methylation and histone methylation are critical elements in self-renewal of male germline stem cells (mGSCs) and spermatogenesis. mGSCs are the only type of adult stem cells able to achieve intergenerational transfer of genetic information, which is accomplished through differentiated sperm cells. However, numerous epigenetic obstacles including incomplete DNA methylation and histone methylation dynamics make establishment of stable livestock mGSC cell lines difficult...
April 2016: Cell Proliferation
https://www.readbyqxmd.com/read/26863630/eif2s3y-suppresses-the-pluripotency-state-and-promotes-the-proliferation-of-mouse-embryonic-stem-cells
#13
Na Li, Hailong Mu, Liming Zheng, Bo Li, Chongyang Wu, Bowen Niu, Qiaoyan Shen, Xin He, Jinlian Hua
Eukaryotic translation initiation factor 2, subunit 3, and structural gene Y-linked (EIF2S3Y) is essential for spermatogenesis in mouse models. However, its effect on embryonic stem (ES) cells remains unknown. In our observation, differentiated ES cells showed higher levels of EIF2S3Y. To further elucidate its role in ES cells, we utilized ES-derived EIF2S3Y-overexpressing cells and found that EIF2S3Y down-regulated the pluripotency state of ES cells, which might be explained by decreased histone methylation levels because of reduced levels of ten-eleven translocation 1 (TET1)...
March 8, 2016: Oncotarget
https://www.readbyqxmd.com/read/26678259/elimination-of-methylation-marks-at-lysines-4-and-9-of-histone-3-h3k4-and-h3k9-of-spermatozoa-alters-offspring-phenotype
#14
Serafín Pérez-Cerezales, Priscila Ramos-Ibeas, Angela Lopez-Cardona, Eva Pericuesta, Raúl Fernandez-Gonzalez, Belen Pintado, Alfonso Gutiérrez-Adán
The contribution of the contents of spermatozoa to the development of the embryo is currently being considered wider than was previously thought. Recent findings point to the participation of epigenetic marks present in the retained histones of mature spermatozoa on embryo and fetal development. Here we created a novel conditional transgenic mouse that expresses lysine (K) demethylase 1a (Kdm1a) during spermatogenesis when the testicles are subjected to heat stress. Using these animals under these conditions we were able to reduce the methylation level of histone 3 at lysines 4 and 9 (H3K4 and H3K9, respectively) in mature spermatozoa...
December 18, 2015: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/26449473/disruption-of-histone-methylation-in-developing-sperm-impairs-offspring-health-transgenerationally
#15
Keith Siklenka, Serap Erkek, Maren Godmann, Romain Lambrot, Serge McGraw, Christine Lafleur, Tamara Cohen, Jianguo Xia, Matthew Suderman, Michael Hallett, Jacquetta Trasler, Antoine H F M Peters, Sarah Kimmins
A father's lifetime experiences can be transmitted to his offspring to affect health and development. However, the mechanisms underlying paternal epigenetic transmission are unclear. Unlike in somatic cells, there are few nucleosomes in sperm, and their function in epigenetic inheritance is unknown. We generated transgenic mice in which overexpression of the histone H3 lysine 4 (H3K4) demethylase KDM1A (also known as LSD1) during spermatogenesis reduced H3K4 dimethylation in sperm. KDM1A overexpression in one generation severely impaired development and survivability of offspring...
November 6, 2015: Science
https://www.readbyqxmd.com/read/26409824/histone-lysine-methylation-exhibits-a-distinct-distribution-during-spermatogenesis-in-pigs
#16
Junhui An, Jinzhou Qin, Yi Wan, Yaqing Zhang, Yuan Hu, Chunfang Zhang, Wenxian Zeng
Spermatogenesis is a continual process throughout the adult life of a male, which is governed by unique transcriptional regulation and massive alterations of chromatin. Histone modification was one of the underlying epigenetic mechanisms during spermatogenesis. It has been shown that methylation of histone lysine exhibits a distinct distribution in mice during spermatogenesis and some histone lysine methylation is essential for male fertility. However, the dynamic change of methylated histone in porcine testis tissue was largely unknown...
December 2015: Theriogenology
https://www.readbyqxmd.com/read/26328105/the-role-of-epigenetics-in-spermatogenesis
#17
REVIEW
Sezgin Güneş, Tuba Kulaç
Male germ cells have a unique morphology and function to facilitate fertilization. Sperm deoxyribonucleic acid (DNA) is highly condensed to protect the paternal genome during transfer from male to oocyte. Sperm cells undergo extensive epigenetic modifications during differentiation to become a mature spermatozoon. Epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling are substantial regulators of spermatogenesis. DNA hypermethylation is associated with gene silencing...
September 2013: Turkish Journal of Urology
https://www.readbyqxmd.com/read/26279298/regulation-of-c-myc-expression-by-the-histone-demethylase-jmjd1a-is-essential-for-prostate-cancer-cell-growth-and-survival
#18
L Fan, G Peng, N Sahgal, L Fazli, M Gleave, Y Zhang, A Hussain, J Qi
The histone demethylase JMJD1A, which controls gene expression by epigenetic regulation of H3K9 methylation marks, functions in diverse activities, including spermatogenesis, metabolism and stem cell self-renewal and differentiation. Here, we found that JMJD1A knockdown in prostate cancer cells antagonizes their proliferation and survival. Profiling array analyses revealed that JMJD1A-dependent genes function in cellular growth, proliferation and survival, and implicated that the c-Myc transcriptional network is deregulated following JMJD1A inhibition...
May 12, 2016: Oncogene
https://www.readbyqxmd.com/read/26268560/methylation-of-the-gpat2-promoter-regulates-transient-expression-during-mouse-spermatogenesis
#19
Maria B Garcia-Fabiani, Mauro A Montanaro, Ezequiel Lacunza, Elizabeth R Cattaneo, Rosalind A Coleman, Magali Pellon-Maison, Maria R Gonzalez-Baro
Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells. Although Gpat2 was originally annotated as encoding a glycerol-3-phosphate acyltransferase by sequence homology to Gpat1, GPAT2 is highly expressed in testis but not in lipogenic tissues and is not up-regulated during adipocyte differentiation. New data show that GPAT2 is required for the synthesis of piRNAs (piwi-interacting RNAs), a group of small RNAs that protect the germ cell genome from retrotransposable elements...
October 15, 2015: Biochemical Journal
https://www.readbyqxmd.com/read/26205254/deleterious-effects-of-obesity-upon-the-hormonal-and-molecular-mechanisms-controlling-spermatogenesis-and-male-fertility
#20
REVIEW
Lien M Davidson, Kate Millar, Celine Jones, Muhammad Fatum, Kevin Coward
Worldwide obesity rates have nearly doubled since 1980 and currently over 10% of the population is obese. In 2008, over 1.4 billion adults aged 20 years and older had a body mass index or BMI above a healthy weight and of these, over 200 million men and nearly 300 million women were obese. While obesity can have many ramifications upon adult life, one growing area of concern is that of reproductive capacity. Obesity affects male infertility by influencing the hypothalamic-pituitary-gonadal axis, thus causing detrimental effects upon spermatogenesis and subsequent fertility...
September 2015: Human Fertility: Journal of the British Fertility Society
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