Weirong Chen, So-Hee Hong, Scott A Jenks, Fabliha A Anam, Christopher M Tipton, Matthew C Woodruff, Jennifer R Hom, Kevin S Cashman, Caterina Elisa Faliti, Xiaoqian Wang, Shuya Kyu, Chungwen Wei, Christopher D Scharer, Tian Mi, Sakeenah Hicks, Louise Hartson, Doan C Nguyen, Arezou Khosroshahi, Saeyun Lee, Youliang Wang, Regina Bugrovsky, Yusho Ishii, F Eun-Hyung Lee, Ignacio Sanz
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by multiple autoantibody types, some of which are produced by long-lived plasma cells (LLPC). Active SLE generates increased circulating antibody-secreting cells (ASC). Here, we examine the phenotypic, molecular, structural, and functional features of ASC in SLE. Relative to post-vaccination ASC in healthy controls, circulating blood ASC from patients with active SLE are enriched with newly generated mature CD19- CD138+ ASC, similar to bone marrow LLPC...
March 1, 2024: Nature Communications