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Marcus Ang, Yijun Cai, Anna C S Tan
Purpose. To describe a novel technique of adapting a swept-source optical coherence tomography angiography (OCTA) to image corneal vascularization. Methods. In this pilot cross-sectional study, we obtained 3 × 3 mm scans, where 100,000 A-scans are acquired per second with optical axial resolution of 8 μm and lateral resolution of 20 μm. This was performed with manual "XYZ" focus without the anterior segment lens, until the focus of the corneoscleral surface was clearly seen and the vessels of interest were in focus on the corresponding red-free image...
2016: Journal of Ophthalmology
Andrea L Gold, Tomer Shechner, Madeline J Farber, Carolyn N Spiro, Ellen Leibenluft, Daniel S Pine, Jennifer C Britton
BACKGROUND: Amygdala-prefrontal cortex (PFC) functional connectivity may be influenced by anxiety and development. A prior study on anxiety found age-specific dysfunction in the ventromedial PFC (vmPFC), but not amygdala, associated with threat-safety discrimination during extinction recall (Britton et al.). However, translational research suggests that amygdala-PFC circuitry mediates responses following learned extinction. Anxiety-related perturbations may emerge in functional connectivity within this circuit during extinction recall tasks...
October 2016: Depression and Anxiety
Neerupma Silswal, Julia Reis, Asaf A Qureshi, Christopher Papasian, Nilofer Qureshi
The molecular basis responsible for tolerance following inflammatory response to LPS is not well-understood. We hypothesized that inflammation/tolerance in monocytes/ macrophages is dependent on the proteases of proteasome. To test our hypothesis, first, we examined the expression of different proteasome subunits in different human and mouse monocytes/macrophages. Secondly, we investigated the effect of proteasome subunits/ proteases on LPS-induced expression of tumor necrosis factor-α (TNF-α) and nitric oxide (NO) during inflammation and tolerance using mouse RAW 264...
September 19, 2016: Shock
Qian Cao, Xiaoxia Wan, Junfeng Li, Jingxing Liang
In this paper, we propose a new interim connection space (ICS) called LabLab, which is an updated version of LabPQR, to overcome the drawback that the last three dimensions of LabPQR have no definite colorimetric meanings. We extended and improved the method by which the first three dimensions of LabPQR are deduced to obtain an ICS consisting of two sets of CIELAB values under different illuminants, and the reconstructed spectra from LabLab were obtained by minimizing colorimetric errors by means of the computational formula of the CIE-XYZ tristimulus values combined with least-squares best fit...
September 1, 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Longhua Yang, Åge A Skjevik, Wen-Ge Han Du, Louis Noodleman, Ross C Walker, Andreas W Götz
Cytochrome c oxidase (CcO) is a vital enzyme that catalyzes the reduction of molecular oxygen to water and pumps protons across mitochondrial and bacterial membranes. This article presents parameters for the cofactors of ba3-type CcO that are compatible with the all-atom Amber ff12SB and ff14SB force fields. Specifically, parameters were developed for the CuA pair, heme b, and the dinuclear center that consists of heme a3 and CuB bridged by a hydroperoxo group. The data includes geometries in XYZ coordinate format for cluster models that were employed to compute proton transfer energies and derive bond parameters and point charges for the force field using density functional theory...
September 2016: Data in Brief
Norisato Tsuda, Kota Mitsui, Shinichiro Oda
The purpose of this study was to investigate the effect of the position in XYZ directions and acquisition parameters on the basic image qualities of for cone beam computed tomography (CBCT) in an angiography system with flat panel detector. The resolution property (modulation transfer function: MTF) and the noise property (Wiener spectrum: WS) of CBCT images in X-Y plane were measured with different acquisition parameters (scan matrix number and projection number) and the effect of the position in XYZ directions...
August 2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
D L Campbell, I B Spielman
We theoretically explore a Rashba spin-orbit coupling scheme which operates entirely in the absolute ground state manifold of an alkali atom, thereby minimizing all inelastic processes. An energy gap between ground eigenstates of the proposed coupling can be continuously opened or closed by modifying laser polarizations. Our technique uses far-detuned 'Raman' laser coupling to create the Rashba potential, which has the benefit of low spontaneous emission rates. At these detunings, the Raman matrix elements that link m F magnetic sublevel quantum numbers separated by two are also suppressed...
March 2016: New Journal of Physics
Asami Aida, Masatoshi Nakajima, Naoko Seki, Yukinori Kano, Richard M Foxton, Junji Tagami
This study aimed to investigate the effect of enamel margin configuration on color change of resin composite restoration. Enamel disks of 1.0 mm-thick were sliced from sixty bovine anterior teeth and divided into three groups by margin configuration (non-bevel, 45-degree bevel and 45-degree reverse-bevel). The color measurements (L*C*h* values) at the restored bovine enamel disk with resin composite (Estelite Asteria, Estelite Pro, Kalore, Clearfil Majesty) were performed using a digital camera with CIE XYZ color gamut (RC500)...
2016: Dental Materials Journal
Chin W Yong
DL_F Notation is an easy-to-understand, standardized atom typesetting expression for molecular simulations for a range of organic force field (FF) schemes such as OPLSAA, PCFF, and CVFF. It is implemented within DL_FIELD, a software program that facilitates the setting up of molecular FF models for DL_POLY molecular dynamics simulation software. By making use of the Notation, a single core conversion module (the DL_F conversion Engine) implemented within DL_FIELD can be used to analyze a molecular structure and determine the types of atoms for a given FF scheme...
August 22, 2016: Journal of Chemical Information and Modeling
Srdjan Čalošević, Kristijan Dinjar, Suzana Čalošević, Sven Kurbel, Robert Steiner
This study is aimed to estimate spatial variability of normal QRS loops trajectories in successive cardiac cycles analyzed in XYZ phase space among 27 young and 27 older subjects, both male and female. Among young subjects, 10 individuals were professional football players, while the remaining 17 were students without regular physical activities. Modified three-axial leads (Frank's lead system) were used continually to record high-resolution ECG (1 kHz sampling rate) at rest during 200 seconds by Biopac Student Lab System...
July 22, 2016: General Physiology and Biophysics
Casper Find Andersen, David Connah
Color correction relates device dependent sensor responses (RGB) to device independent color values (XYZ). Here we present a new approach to Hue-plane Preserving Color Correction (HPPCC) using weighted constrained 3 × 3 matrices. Hue-plane preservation was introduced in [1] in conjunction with an HPPCC method. That method maps using a finite number of local white point preserving 3 × 3 matrices, each of which operates in a hue-angle delimited subregion of device space defined by the white and two adjacent chromatic training set colors...
July 11, 2016: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
Kate Grieve, Olivier Thouvenin, Abhishek Sengupta, Vincent M Borderie, Michel Paques
PURPOSE: To interpret full-field optical coherence tomography (FFOCT) images of ex vivo retina. METHODS: Flatmounted retinas of human, primate, pig, sheep, rat, and mouse were imaged using FFOCT. To identify retinal ganglion and amacrine cells, fixed samples immunolabeled against Tuj1 and Brn3a or live samples labeled in vitro with green fluorescent protein (GFP) were analyzed by combining FFOCT, fluorescence confocal microscopy (FCM), and fluorescence-FFOCT. To investigate postmortem tissue changes, time series were acquired over 48 hours and on fresh versus fixed tissue...
July 1, 2016: Investigative Ophthalmology & Visual Science
Yuji Nashimoto, Yasufumi Takahashi, Yuanshu Zhou, Hidenori Ito, Hiroki Ida, Kosuke Ino, Tomokazu Matsue, Hitoshi Shiku
Information regarding spatial mRNA localization in single cells is necessary for a better understanding of cellular functions in tissues. Here, we report a method for evaluating localization of mRNA in single cells using double-barrel scanning ion conductance microscopy (SICM). Two barrels in a nanopipette were filled with aqueous and organic electrolyte solutions and used for SICM and as an electrochemical syringe, respectively. We confirmed that the organic phase barrel could be used to collect cytosol from living cells, which is a minute but sufficient amount to assess cellular status using qPCR analysis...
July 26, 2016: ACS Nano
Jonatan Jacobsson, Rasmus Borgquist, Christian Reitan, Elyar Ghafoori, Neal A Chatterjee, Muammar Kabir, Pyotr G Platonov, Jonas Carlson, Jagmeet P Singh, Larisa G Tereshchenko
Cardiac resynchronization therapy (CRT) reduces mortality and morbidity in selected patients with heart failure (HF), but up to 1/3 of patients are nonresponders. Sum absolute QRST integral (SAI QRST) recently showed association with mechanical response on CRT. However, it is unknown whether SAI QRST is associated with all-cause mortality and HF hospitalizations in patients undergoing CRT. The study population included 496 patients undergoing CRT (mean age 69 ± 10 years, 84% men, 65% left bundle branch block [LBBB], left ventricular ejection fraction 23 ± 6%, 63% ischemic cardiomyopathy)...
August 1, 2016: American Journal of Cardiology
Melody N Carney, William M Johnston
OBJECTIVES: Objectives of this study were to correlate RGB data from the VITA Linearguide 3D Master and VITA Bleached Guide 3D Master shade guides with their spectroradiometric correlates through a regression model while indicating a methodology for validation of accuracy of digital imaging systems. Additional objectives were to provide summary RGB data and to determine a relationship between lightness and RGB values for these shade guides. METHODS: Radiant energy measurements and images were taken with a Canon Rebel T3i and Macro Ring Lite MR-14EX for each shade tab...
August 2016: Journal of Dentistry
Larisa G Tereshchenko, Elyar Ghafoori, Muammar M Kabir, Markus Kowalsky
AIM: The goal of this study was to compare associations between clinical and ECG predictors of cardiac resynchronization therapy (CRT) response with electrical dyssynchrony. METHODS: Body-surface potentials were recorded using a 120-lead system in 4 patients (age 62 ± 12 y, left ventricular ejection fraction (LVEF) 29 ± 5 %; QRS duration 154 ± 19 ms) with post-myocardial infarction scar and left bundle branch block before CRT implantation. A patient-specific heart-torso model derived from MRI with 291 heart-surface nodes was developed...
September 2015: Computing in Cardiology
Suqing Zheng, Qing Tang, Jian He, Shiyu Du, Shaofang Xu, Chaojie Wang, Yong Xu, Fu Lin
Force fields are fundamental to molecular dynamics simulations. However, the incompleteness of force field parameters has been a long-standing problem, especially for metal-related systems. In our previous work, we adopted the Seminario method based on the Hessian matrix to systematically derive the zinc-related force field parameters for AMBER. In this work, in order to further simplify the whole protocol, we have implemented a user-friendly Visual Force Field Derivation Toolkit (VFFDT) to derive the force field parameters via simply clicking on the bond or angle in the 3D viewer, and we have further extended our previous program to support the Hessian matrix output from a variety of quantum mechanics (QM) packages, including Gaussian 03/09, ORCA 3...
April 25, 2016: Journal of Chemical Information and Modeling
Xiandou Zhang, Brian Funt, Hamidreza Mirzaei
Metamer mismatching (the phenomenon that two objects matching in color under one illuminant may not match under a different illuminant) potentially has important consequences for color perception. Logvinenko et al. [PLoS ONE10, e0135029 (2015)] show that in theory the extent of metamer mismatching can be very significant. This paper examines metamer mismatching in practice by computing the volumes of the empirical metamer mismatch bodies and comparing them to the volumes of the theoretical mismatch bodies. A set of more than 25 million unique reflectance spectra is assembled using datasets from several sources...
March 2016: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
Nestor Saiz, Minjung Kang, Nadine Schrode, Xinghua Lou, Anna-Katerina Hadjantonakis
This protocol presents a method to perform quantitative, single-cell in situ analyses of protein expression to study lineage specification in mouse preimplantation embryos. The procedures necessary for embryo collection, immunofluorescence, imaging on a confocal microscope, and image segmentation and analysis are described. This method allows quantitation of the expression of multiple nuclear markers and the spatial (XYZ) coordinates of all cells in the embryo. It takes advantage of MINS, an image segmentation software tool specifically developed for the analysis of confocal images of preimplantation embryos and embryonic stem cell (ESC) colonies...
2016: Journal of Visualized Experiments: JoVE
Ramon Fuentes, Pablo Navarro, Aldo Curiqueo, Nicolas E Ottone
The electromagnetic articulograph (EMA) is a device that can collect movement data by positioning sensors at multiple points, measuring displacements of the structure in real time, as well as the acoustics and mechanics of speech using a microphone connected to the measurement system. The aim of this study is to describe protocols for the generation, measurement and visualization of mandibular border and functional movements in the three spatial planes (frontal, sagittal and horizontal) using the EMA. The EMA has transmitter coils that determine magnetic fields to collect information about movements from sensors located on different structures (tongue, palate, mouth, incisors, skin, etc...
2015: International Journal of Clinical and Experimental Medicine
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