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https://www.readbyqxmd.com/read/29675000/exploring-additional-dimensions-of-complexity-in-inhibitor-design-for-serine-%C3%AE-lactamases-mechanistic-and-intra-and-inter-molecular-chemistry-approaches
#1
REVIEW
Focco van den Akker, Robert A Bonomo
As a bacterial resistance strategy, serine β-lactamases have evolved from cell wall synthesizing enzymes known as penicillin-binding proteins (PBP), by not only covalently binding β-lactam antibiotics but, also acquiring mechanisms of deacylating these antibiotics. This critical deacylation step leads to release of hydrolyzed and inactivated β-lactams, thereby providing resistance for the bacteria against these antibiotics targeting the cell wall. To combat β-lactamase-mediated antibiotic resistance, numerous β-lactamase inhibitors were developed that utilize various strategies to inactivate the β-lactamase...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29651995/investigation-of-tbmn-sub-2-sub-o-sub-5-sub-by-polarized-neutron-diffraction
#2
Igor Aleksandrovich Zobkalo, Sergei Gavrilov, Andrew Sazonov, Vladimir Hutanu
In order to make a new approach to the elucidation of the microscopic mechanisms of multiferroicity in RMn2O5 family, experiments with different methods of polarized neutrons scattering were performed on a TbMn2O5 single crystal. We employed three different techniques of polarized neutron diffraction: without the analysis after scattering, the XYZ-polarization analysis, and technique of spherical neutron polarimetry (SNP). Measurements with SNP were undertaken both with and without external electric field. A characteristic difference in the population of "right" and "left" helix domains in all magnetically ordered phases of TbMn2O5, was observed...
April 13, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29603955/computational-color-prediction-versus-least-dissimilar-matching
#3
Emitis Roshan, Brian Funt
The performance of color prediction methods CIECAM02, KSM2 , Waypoint, Best Linear, Metamer Mismatch Volume Center, and Relit color signal are compared in terms of how well they explain Logvinenko and Tokunaga's asymmetric color matching results [Seeing Perceiving24, 407 (2011)]. In their experiment, four observers were asked to determine (three repeats) for a given Munsell paper under a test illuminant which of 22 other Munsell papers was the least-dissimilar under a match illuminant. Their use of "least-dissimilar" as opposed to "matching" is an important aspect of their experiment...
April 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29603944/computerized-simulation-of-color-appearance-for-anomalous-trichromats-using-the-multispectral-image
#4
Hirohisa Yaguchi, Junyan Luo, Miharu Kato, Yoko Mizokami
Most color simulators for color deficiencies are based on the tristimulus values and are intended to simulate the appearance of an image for dichromats. Statistics show that there are more anomalous trichromats than dichromats. Furthermore, the spectral sensitivities of anomalous cones are different from those of normal cones. Clinically, the types of color defects are characterized through Rayleigh color matching, where the observer matches a spectral yellow to a mixture of spectral red and green. The midpoints of the red/green ratios deviate from a normal trichromat...
April 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29541495/rgb-camera-based-imaging-of-cerebral-tissue-oxygen-saturation-hemoglobin-concentration-and-hemodynamic-spontaneous-low-frequency-oscillations-in-rat-brain-following-induction-of-cortical-spreading-depression
#5
Afrina Mustari, Naoki Nakamura, Satoko Kawauchi, Shunichi Sato, Manabu Sato, Izumi Nishidate
To evaluate cerebral hemodynamics and spontaneous low-frequency oscillations (SLFOs) of cerebral blood flow in rat brain, we investigated an imaging method using a digital RGB camera. In this method, the RGB values were converted into tristimulus values in the CIE (Commission Internationale de l'Eclairage) XYZ color space, which is compatible with the common RGB working spaces. Monte Carlo simulation for light transport in tissue was then used to specify the relationship among the tristimulus XYZ values and the concentrations of oxygenated hemoglobin ( C HbO ), deoxygenated hemoglobin ( C HbR ), and total hemoglobin ( C HbT ) and cerebral tissue oxygen saturation ( StO 2 )...
March 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29519490/intramuscular-gluteal-augmentation-the-xyz-method
#6
REVIEW
Raul Gonzalez, Ricardo Gonzalez
Although interest in buttocks implant procedures is growing around the world, it remains a technically demanding procedure. The intramuscular plane is thought to be superior to other planes of dissection. Asymmetry and visibility of the implants remain frequent complications when the surgeon works without any reference points to guide the procedure. The XYZ method helps the surgeon to obtain symmetry, to significantly reduce implant visibility and to decrease other complications associated with buttocks implants...
April 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29347190/exact-phase-boundaries-and-topological-phase-transitions-of-the-xyz-spin-chain
#7
S A Jafari
Within the block spin renormalization group, we give a very simple derivation of the exact phase boundaries of the XYZ spin chain. First, we identify the Ising order along x[over ̂] or y[over ̂] as attractive renormalization group fixed points of the Kitaev chain. Then, in a global phase space composed of the anisotropy λ of the XY interaction and the coupling Δ of the Δσ^{z}σ^{z} interaction, we find that the above fixed points remain attractive in the two-dimesional parameter space. We therefore classify the gapped phases of the XYZ spin chain as: (1) either attracted to the Ising limit of the Kitaev-chain, which in turn is characterized by winding number ±1, depending on whether the Ising order parameter is along x[over ̂] or y[over ̂] directions; or (2) attracted to the charge density wave (CDW) phases of the underlying Jordan-Wigner fermions, which is characterized by zero winding number...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29286412/basic-research-in-plasma-medicine-a-throughput-approach-from-liquids-to-cells
#8
Sander Bekeschus, Anke Schmidt, Felix Niessner, Torsten Gerling, Klaus-Dieter Weltmann, Kristian Wende
In plasma medicine, ionized gases with temperatures close to that of vertebrate systems are applied to cells and tissues. Cold plasmas generate reactive species known to redox regulate biological processes in health and disease. Pre-clinical and clinical evidence points to beneficial effects of plasma treatment in the healing of chronic ulcer of the skin. Other emerging topics, such as plasma cancer treatment, are receiving increasing attention. Plasma medical research requires interdisciplinary expertise in physics, chemistry, and biomedicine...
November 17, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29225279/influence-of-enamel-prism-orientations-on-color-shifting-at-the-border-of-resin-composite-restorations
#9
Yukinori Kano, Masatoshi Nakajima, Asami Aida, Naoko Seki, Richard M Foxton, Junji Tagami
This study aimed to investigate the influence of enamel prism orientations on color adjustment of resin composite restoration. The color measurements (L*, C*, or h* values) at the restored bovine enamel disk (1.0 mm-thick) with resin composite (Estelite Asteria, Estelite Pro, Kalore, Clearfil Majesty) were performed using a CIE XYZ camera (RC500). The color shifting rate and range at the coronal and cervical border were calculated. The coronal border was significantly lower L* and C* color shifting rate than the cervical border (p<0...
December 8, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/29097666/a-simple-tensor-network-algorithm-for-two-dimensional-steady-states
#10
Augustine Kshetrimayum, Hendrik Weimer, Román Orús
Understanding dissipation in 2D quantum many-body systems is an open challenge which has proven remarkably difficult. Here we show how numerical simulations for this problem are possible by means of a tensor network algorithm that approximates steady states of 2D quantum lattice dissipative systems in the thermodynamic limit. Our method is based on the intuition that strong dissipation kills quantum entanglement before it gets too large to handle. We test its validity by simulating a dissipative quantum Ising model, relevant for dissipative systems of interacting Rydberg atoms, and benchmark our simulations with a variational algorithm based on product and correlated states...
November 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/29049033/squeezed-dirac-and-topological-magnons-in-a-bosonic-honeycomb-optical-lattice
#11
S A Owerre, J Nsofini
Quantum information storage using charge-neutral quasiparticles is expected to play a crucial role in the future of quantum computers. In this regard, magnons or collective spin-wave excitations in solid-state materials are promising candidates in the future of quantum computing. Here, we study the quantum squeezing of Dirac and topological magnons in a bosonic honeycomb optical lattice with spin-orbit interaction by utilizing the mapping to quantum spin-[Formula: see text] XYZ Heisenberg model on the honeycomb lattice with discrete Z2 symmetry and a Dzyaloshinskii-Moriya interaction...
October 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29039868/inkjet-printed-barcodes-for-a-rapid-and-multiplexed-paper-based-assay-compatible-with-mobile-devices
#12
Mingzhu Yang, Wei Zhang, Wenshu Zheng, Fengjing Cao, Xingyu Jiang
This study reports a simple, rapid, low-cost, robust, and multiplexed barcoded paper-based assay (BPA) compatible with mobile devices. An inkjet printer and an XYZ dispensing platform were used to realize mass-manufacturing of barcoded paper-based analytical devices (BPADs) with high precision and efficiency. We designed a new group of barcodes and developed an application (APP) for the reading of the new code. The new barcodes possess a 16 times higher coding capacity than the standard Codabar code in our experiment on drug residue detection...
November 7, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28976183/ion-source-with-laser-triangulation-for-ambient-mass-spectrometry-of-nonplanar-samples
#13
Jan Rejšek, Vladimír Vrkoslav, Vít Pokorný, Vladimír Přibyl, Josef Cvačka
The analysis of nonplanar samples in ambient mass spectrometry poses a formidable challenge. Here, an ion source equipped with laser triangulation for analyzing nonplanar surfaces was constructed. It was designed as a two-position device, where the sample height was measured using laser triangulation and the target compounds were then analyzed. Thanks to a stage movable in xyz, the ion source maintained an optimal vertical distance between the sample and the sampling capillary for each measured spot during the surface analysis...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28940444/accurate-representation-of-interference-colours-michel-l%C3%A3-vy-chart-from-rendering-to-image-colour-correction
#14
S A Linge Johnsen, J Bollmann, H W Lee, Y Zhou
Here a work flow towards an accurate representation of interference colours (Michel-Lévy chart) digitally captured on a polarised light microscope using dry and oil immersion objectives is presented. The work flow includes accurate rendering of interference colours considering the colour temperature of the light source of the microscope and chromatic adaptation to white points of RGB colour spaces as well as the colour correction of the camera using readily available colour targets. The quality of different colour correction profiles was tested independently on an IT8...
March 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/28930101/squeezed-dirac-and-topological-magnons-in-a-bosonic-honeycomb-optical-lattice
#15
Solomon Owerre, Joachim Nsofini
Quantum information storage using charge-neutral quasiparticles are expected to play a crucial role in the future of quantum computers. In this regard, magnons or collective spin-wave excitations in solid-state materials are promising candidates in the future of quantum computing. Here, we study the quantum squeezing of Dirac and topological magnons in a bosonic honeycomb optical lattice with spin-orbit interaction by utilizing the mapping to quantum spin-$1/2$ XYZ Heisenberg model on the honeycomb lattice with discrete Z$_2$ symmetry and a Dzyaloshinskii-Moriya interaction...
September 20, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28898756/bioreactor-culture-duration-of-engineered-constructs-influences-bone-formation-by-mesenchymal-stem-cells
#16
Debika Mitra, Jacklyn Whitehead, Osamu W Yasui, J Kent Leach
Perfusion culture of mesenchymal stem cells (MSCs) seeded in biomaterial scaffolds provides nutrients for cell survival, enhances extracellular matrix deposition, and increases osteogenic cell differentiation. However, there is no consensus on the appropriate perfusion duration of cellular constructs in vitro to boost their bone forming capacity in vivo. We investigated this phenomenon by culturing human MSCs in macroporous composite scaffolds in a direct perfusion bioreactor and compared their response to scaffolds in continuous dynamic culture conditions on an XYZ shaker...
November 2017: Biomaterials
https://www.readbyqxmd.com/read/28870990/three-dimensional-automated-reporter-quantification-3d-arq-technology-enables-quantitative-screening-in-retinal-organoids
#17
M Natalia Vergara, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Minda McNally, Karl J Wahlin, Meera T Saxena, Jeff S Mumm, M Valeria Canto-Soler
The advent of stem cell-derived retinal organoids has brought forth unprecedented opportunities for developmental and physiological studies, while presenting new therapeutic promise for retinal degenerative diseases. From a translational perspective, organoid systems provide exciting new prospects for drug discovery, offering the possibility to perform compound screening in a three-dimensional (3D) human tissue context that resembles the native histoarchitecture and to some extent recapitulates cellular interactions...
October 15, 2017: Development
https://www.readbyqxmd.com/read/28751668/signatures-of-a-magnetic-field-induced-unconventional-nematic-liquid-in-the-frustrated-and-anisotropic-spin-chain-cuprate-licusbo4
#18
H-J Grafe, S Nishimoto, M Iakovleva, E Vavilova, L Spillecke, A Alfonsov, M-I Sturza, S Wurmehl, H Nojiri, H Rosner, J Richter, U K Rößler, S-L Drechsler, V Kataev, B Büchner
Modern theories of quantum magnetism predict exotic multipolar states in weakly interacting strongly frustrated spin-1/2 Heisenberg chains with ferromagnetic nearest neighbor (NN) inchain exchange in high magnetic fields. Experimentally these states remained elusive so far. Here we report strong indications of a magnetic field-induced nematic liquid arising above a field of ~13 T in the edge-sharing chain cuprate LiSbCuO4 ≡ LiCuSbO4. This interpretation is based on the observation of a field induced spin-gap in the measurements of the (7)Li NMR spin relaxation rate T 1(-1) as well as a contrasting field-dependent power-law behavior of T 1(-1) vs...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28745630/subpial-adeno-associated-virus-9-aav9-vector-delivery-in-adult-mice
#19
Takahiro Tadokoro, Atsushi Miyanohara, Michael Navarro, Kota Kamizato, Stefan Juhas, Jana Juhasova, Silvia Marsala, Oleksandr Platoshyn, Erik Curtis, Brandon Gabel, Joseph Ciacci, Nada Lukacova, Katarina Bimbova, Martin Marsala
The successful development of a subpial adeno-associated virus 9 (AAV9) vector delivery technique in adult rats and pigs has been reported on previously. Using subpially-placed polyethylene catheters (PE-10 or PE-5) for AAV9 delivery, potent transgene expression through the spinal parenchyma (white and gray matter) in subpially-injected spinal segments has been demonstrated. Because of the wide range of transgenic mouse models of neurodegenerative diseases, there is a strong desire for the development of a potent central nervous system (CNS)-targeted vector delivery technique in adult mice...
July 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28689986/quaternion-based-study-of-angular-velocity-of-the-cardiac-vector-during-myocardial-ischaemia
#20
Pablo Daniel Cruces, Pedro David Arini
BACKGROUND: Early detection of acute ischaemia through non-invasive methods remains a challenge in health research. Ischaemic condition caused by a decrease in the blood supply in a cardiac region induces hypoxia and metabolic abnormalities that contribute to the electrical instability of the heart and to the development of slow conduction in damaged tissue. METHODS: Herein, a percutaneous transluminal coronary angiography (PTCA) is considered as a model of supply ischaemia...
December 1, 2017: International Journal of Cardiology
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