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https://www.readbyqxmd.com/read/28930101/squeezed-dirac-and-topological-magnons-in-a-bosonic-honeycomb-optical-lattice
#1
Solomon Owerre, Joachim Nsofini
Quantum information storage using charge-neutral quasiparticles are expected to play a crucial role in the future of quantum computers. In this regard, magnons or collective spin-wave excitations in solid-state materials are promising candidates in the future of quantum computing. Here, we study the quantum squeezing of Dirac and topological magnons in a bosonic honeycomb optical lattice with spin-orbit interaction by utilizing the mapping to quantum spin-$1/2$ XYZ Heisenberg model on the honeycomb lattice with discrete Z$_2$ symmetry and a Dzyaloshinskii-Moriya interaction...
September 20, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28898756/bioreactor-culture-duration-of-engineered-constructs-influences-bone-formation-by-mesenchymal-stem-cells
#2
Debika Mitra, Jacklyn Whitehead, Osamu W Yasui, J Kent Leach
Perfusion culture of mesenchymal stem cells (MSCs) seeded in biomaterial scaffolds provides nutrients for cell survival, enhances extracellular matrix deposition, and increases osteogenic cell differentiation. However, there is no consensus on the appropriate perfusion duration of cellular constructs in vitro to boost their bone forming capacity in vivo. We investigated this phenomenon by culturing human MSCs in macroporous composite scaffolds in a direct perfusion bioreactor and compared their response to scaffolds in continuous dynamic culture conditions on an XYZ shaker...
September 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/28870990/enabling-quantitative-screening-in-retinal-organoids-3d-automated-reporter-quantification-technology-3d-arq
#3
M Natalia Vergara, Miguel Flores-Bellver, Silvia Aparicio-Domingo, Minda McNally, Karl J Wahlin, Meera T Saxena, Jeff S Mumm, M Valeria Canto-Soler
The advent of stem cell-derived retinal organoids has brought forth unprecedented opportunities for developmental and physiological studies, while presenting new therapeutic promise for retinal degenerative diseases. From a translational perspective, organoid systems provide exciting new prospects for drug discovery, offering the possibility to perform compound screening in a 3-dimensional (3D) human tissue context that resembles the native histoarchitecture and cellular interactions. However, inherent variability issues and a general lack of robust quantitative technologies for analyzing organoids in large-scale pose severe limitations for their use in translational applications...
September 4, 2017: Development
https://www.readbyqxmd.com/read/28751668/signatures-of-a-magnetic-field-induced-unconventional-nematic-liquid-in-the-frustrated-and-anisotropic-spin-chain-cuprate-licusbo4
#4
H-J Grafe, S Nishimoto, M Iakovleva, E Vavilova, L Spillecke, A Alfonsov, M-I Sturza, S Wurmehl, H Nojiri, H Rosner, J Richter, U K Rößler, S-L Drechsler, V Kataev, B Büchner
Modern theories of quantum magnetism predict exotic multipolar states in weakly interacting strongly frustrated spin-1/2 Heisenberg chains with ferromagnetic nearest neighbor (NN) inchain exchange in high magnetic fields. Experimentally these states remained elusive so far. Here we report strong indications of a magnetic field-induced nematic liquid arising above a field of ~13 T in the edge-sharing chain cuprate LiSbCuO4 ≡ LiCuSbO4. This interpretation is based on the observation of a field induced spin-gap in the measurements of the (7)Li NMR spin relaxation rate T 1(-1) as well as a contrasting field-dependent power-law behavior of T 1(-1) vs...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28745630/subpial-adeno-associated-virus-9-aav9-vector-delivery-in-adult-mice
#5
Takahiro Tadokoro, Atsushi Miyanohara, Michael Navarro, Kota Kamizato, Stefan Juhas, Jana Juhasova, Silvia Marsala, Oleksandr Platoshyn, Erik Curtis, Brandon Gabel, Joseph Ciacci, Nada Lukacova, Katarina Bimbova, Martin Marsala
The successful development of a subpial adeno-associated virus 9 (AAV9) vector delivery technique in adult rats and pigs has been reported on previously. Using subpially-placed polyethylene catheters (PE-10 or PE-5) for AAV9 delivery, potent transgene expression through the spinal parenchyma (white and gray matter) in subpially-injected spinal segments has been demonstrated. Because of the wide range of transgenic mouse models of neurodegenerative diseases, there is a strong desire for the development of a potent central nervous system (CNS)-targeted vector delivery technique in adult mice...
July 13, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28689986/quaternion-based-study-of-angular-velocity-of-the-cardiac-vector-during-myocardial-ischaemia
#6
Pablo Daniel Cruces, Pedro David Arini
BACKGROUND: Early detection of acute ischaemia through non-invasive methods remains a challenge in health research. Ischaemic condition caused by a decrease in the blood supply in a cardiac region induces hypoxia and metabolic abnormalities that contribute to the electrical instability of the heart and to the development of slow conduction in damaged tissue. METHODS: Herein, a percutaneous transluminal coronary angiography (PTCA) is considered as a model of supply ischaemia...
June 30, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28648473/qualification-of-a-precision-pattern-dispenser
#7
Raf Van Ammel, Katarzyna Sobiech-Matura, Uwe Wätjen, Tom Vercammen, Pieter Castelein, Roel Wuyts, Johan Paul
In order to automate sample preparation processes, a precision pattern dispenser was designed to reproducibly dispense radioactive solutions at pre-defined positions. It is composed of an automatic liquid sample handling unit coupled to an XYZ table. Qualification tests were conducted to evaluate the performance of the instrument and to assess the compliance with the requirements, in particular trueness (< 2%) and repeatability (< 1%). The instrument allows preparing sources in different source holders and on air filters, in a fast and accurate way...
June 16, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28636327/maldi-ms-guided-liquid-microjunction-extraction-for-capillary-electrophoresis-electrospray-ionization-ms-analysis-of-single-pancreatic-islet-cells
#8
Troy J Comi, Monika A Makurath, Marina C Philip, Stanislav S Rubakhin, Jonathan V Sweedler
The ability to characterize chemical heterogeneity in biological structures is essential to understanding cellular-level function in both healthy and diseased states, but these variations remain difficult to assess using a single analytical technique. While mass spectrometry (MS) provides sufficient sensitivity to measure many analytes from volume-limited samples, each type of mass spectrometric analysis uncovers only a portion of the complete chemical profile of a single cell. Matrix-assisted laser desorption/ionization (MALDI) MS and capillary electrophoresis electrospray ionization (CE-ESI)-MS are complementary analytical platforms frequently utilized for single-cell analysis...
July 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28556892/a-novel-method-to-analyse-in-vivo-the-physiological-state-and-cell-viability-of-phototrophic-microorganisms-by-confocal-laser-scanning-microscopy-using-a-dual-laser
#9
Laia Millach, Aleix Obiol, Antonio Solé, Isabel Esteve
Phototrophic microorganisms are very abundant in extreme environments, where are subjected to frequent and strong changes in environmental parameters. Nevertheless, little is known about the physiological effects of these changing environmental conditions on viability of these microorganisms, which are difficult to grow in solid media and have the tendency to form aggregates. For that reason, it is essential to develop methodologies that provide data in short time consuming, in vivo and with minimal manipulating the samples, in response to distinct stress conditions...
May 30, 2017: Journal of Microscopy
https://www.readbyqxmd.com/read/28505014/validation-of-a-smartphone-auscultatory-blood-pressure-kit-accutension-xyz-110-in-adults-according-to-the-ansi-aami-iso-81060-2-2013-standard
#10
Guang Chu, Zhi Zhang, Mengdan Xu, Daini Huang, Qiuyan Dai
OBJECTIVE: The aim of this study was to validate the accuracy of the Accutension XYZ-110 blood pressure (BP) kit according to the American National Standards Institute/Association for the Advancement of Medical Instrumentation/International Organization for Standardization (ANSI/AAMI/ISO) 81060-2:2013 standard. PARTICIPANTS AND METHODS: Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured simultaneously on the same arm in 85 Chinese adults (female : male=48 : 37) with a mean age of 43...
October 2017: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/28474942/emergence-of-supersymmetric-quantum-electrodynamics
#11
Shao-Kai Jian, Chien-Hung Lin, Joseph Maciejko, Hong Yao
Supersymmetric (SUSY) gauge theories such as the minimal supersymmetric standard model play a fundamental role in modern particle physics, but have not been verified so far in nature. Here, we show that a SUSY gauge theory with dynamical gauge bosons and fermionic gauginos emerges naturally at the pair-density-wave (PDW) quantum phase transition on the surface of a correlated topological insulator hosting three Dirac cones, such as the topological Kondo insulator SmB_{6}. At the quantum tricritical point between the surface Dirac semimetal and nematic PDW phases, three massless bosonic Cooper pair fields emerge as the superpartners of three massless surface Dirac fermions...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28448053/automated-contraction-analysis-of-human-engineered-heart-tissue-for-cardiac-drug-safety-screening
#12
Ingra Mannhardt, Umber Saleem, Anika Benzin, Thomas Schulze, Birgit Klampe, Thomas Eschenhagen, Arne Hansen
Cardiac tissue engineering describes techniques to constitute three dimensional force-generating engineered tissues. For the implementation of these procedures in basic research and preclinical drug development, it is important to develop protocols for automated generation and analysis under standardized conditions. Here, we present a technique to generate engineered heart tissue (EHT) from cardiomyocytes of different species (rat, mouse, human). The technique relies on the assembly of a fibrin-gel containing dissociated cardiomyocytes between elastic polydimethylsiloxane (PDMS) posts in a 24-well format...
April 15, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28426946/quantification-of-rubidium-as-a-trace-element-in-beef-using-laser-induced-breakdown-spectroscopy
#13
Y Dixit, Maria P Casado-Gavalda, R Cama-Moncunill, Maria Markiewicz-Keszycka, X Cama-Moncunill, P J Cullen, Carl Sullivan
This study evaluates the potential of laser induced breakdown spectroscopy (LIBS) coupled with chemometrics to develop a quantification model for rubidium (Rb) in minced beef. A LIBSCAN 150 system was used to collect LIBS spectra of minced beef samples. Beef liver was used to spike the Rb levels in minced beef. All samples were dried, powdered and pelleted using a hydraulic press. Measurements were conducted by scanning 100 different locations with an automated XYZ sample chamber. Partial least squares regression (PLSR) was used to develop the calibration model, yielding a calibration coefficient of determination (Rc(2)) of 0...
August 2017: Meat Science
https://www.readbyqxmd.com/read/28370277/3d-electron-microscopic-characterization-of-interstitial-cells-in-the-human-bladder-upper-lamina-propria
#14
Jochen Neuhaus, Birgit Schröppel, Martin Dass, Hans Zimmermann, Hartwig Wolburg, Petra Fallier-Becker, Thomas Gevaert, Claus J Burkhardt, Hoang Minh Do, Jens-Uwe Stolzenburg
AIMS: To explore the ultrastructure of interstitial cells in the upper lamina propria of the human bladder, to describe the spatial relationships and to investigate cell-cell contacts. METHODS: Focused ion beam scanning electron microscopy (FIB-SEM), 3-View SEM and confocal laser scanning microscopy were used to analyze the 3D ultrastructure of the upper lamina propria in male and female human bladders. RESULTS: 3View-SEM image stacks as large as 59 × 59 × 17 μm(3) (xyz) at a resolution of 16 × 16 × 50 nm(3) and high resolution (5 × 5 × 10 nm(3) ) FIB-SEM stacks could be analyzed...
March 31, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28268576/pixel-based-skin-segmentation-in-psoriasis-images
#15
Y George, M Aldeen, R Garnavi
In this paper, we present a detailed comparison study of skin segmentation methods for psoriasis images. Different techniques are modified and then applied to a set of psoriasis images acquired from the Royal Melbourne Hospital, Melbourne, Australia, with aim of finding the best technique suited for application to psoriasis images. We investigate the effect of different colour transformations on skin detection performance. In this respect, explicit skin thresholding is evaluated with three different decision boundaries (CbCr, HS and rgHSV)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28249537/a-novel-design-of-a-scanning-probe-microscope-integrated-with-an-ultramicrotome-for-serial-block-face-nanotomography
#16
Anton E Efimov, Igor I Agapov, Olga I Agapova, Vladimir A Oleinikov, Alexey V Mezin, Michael Molinari, Igor Nabiev, Konstantin E Mochalov
We present a new concept of a combined scanning probe microscope (SPM)/ultramicrotome apparatus. It enables "slice-and-view" scanning probe nanotomography measurements and 3D reconstruction of the bulk sample nanostructure from series of SPM images after consecutive ultrathin sections. The sample is fixed on a flat XYZ scanning piezostage mounted on the ultramicrotome arm. The SPM measuring head with a cantilever tip and a laser-photodiode tip detection system approaches the sample for SPM measurements of the block-face surface immediately after the ultramicrotome sectioning is performed...
February 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28242414/uv-vis-spectroscopy-and-colorimetric-models-for-detecting-anthocyanin-metal-complexes-in-plants-an-overview-of-in-vitro-and-in-vivo-techniques
#17
REVIEW
Volodymyr S Fedenko, Sergiy A Shemet, Marco Landi
Although anthocyanin (ACN) biosynthesis is one of the best studied pathways of secondary metabolism in plants, the possible physiological and ecological role(s) of these pigments continue to intrigue scientists. Like other dihydroxy B-ring substituted flavonoids, ACNs have an ability to bind metal and metalloid ions, a property that has been exploited for a variety of purposes. For example, the metal binding ability may be used to stabilize ACNs from plant food sources, or to modify their colors for using them as food colorants...
May 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/28226754/pixel-based-skin-segmentation-in-psoriasis-images
#18
Y George, M Aldeen, R Garnavi, Y George, M Aldeen, R Garnavi, M Aldeen, Y George, R Garnavi
In this paper, we present a detailed comparison study of skin segmentation methods for psoriasis images. Different techniques are modified and then applied to a set of psoriasis images acquired from the Royal Melbourne Hospital, Melbourne, Australia, with aim of finding the best technique suited for application to psoriasis images. We investigate the effect of different colour transformations on skin detection performance. In this respect, explicit skin thresholding is evaluated with three different decision boundaries (CbCr, HS and rgHSV)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28187885/automated-characterization-and-counting-of-ki-67-protein-for-breast-cancer-prognosis-a-quantitative-immunohistochemistry-approach
#19
Tushar Mungle, Suman Tewary, Indu Arun, Bijan Basak, Sanjit Agarwal, Rosina Ahmed, Sanjoy Chatterjee, Asok Kumar Maity, Chandan Chakraborty
Ki-67 protein expression plays an important role in predicting the proliferative status of tumour cells and deciding the future course of therapy in breast cancer. Immunohistochemical (IHC) determination of Ki-67 score or labelling index, by estimating the fraction of Ki67 positively stained tumour cells, is the most widely practiced method to assess tumour proliferation (Dowsett et al. 2011). Accurate manual counting of these cells (specifically nuclei) due to complex and dense distribution of cells, therefore, becomes critical and presents a major challenge to pathologists...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28186118/dynamic-in-situ-sensing-of-fluid-dispersed-2d-materials-integrated-on-microfluidic-si-chip
#20
Benjamin T Hogan, Sergey A Dyakov, Lorcan J Brennan, Salma Younesy, Tatiana S Perova, Yurii K Gun'ko, Monica F Craciun, Anna Baldycheva
In this work, we propose a novel approach for wafer-scale integration of 2D materials on CMOS photonic chip utilising methods of synthetic chemistry and microfluidics technology. We have successfully demonstrated that this approach can be used for integration of any fluid-dispersed 2D nano-objects on silicon-on-insulator photonics platform. We demonstrate for the first time that the design of an optofluidic waveguide system can be optimised to enable simultaneous in-situ Raman spectroscopy monitoring of 2D dispersed flakes during the device operation...
February 10, 2017: Scientific Reports
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