keyword
MENU ▼
Read by QxMD icon Read
search

Clinostat

keyword
https://www.readbyqxmd.com/read/27908795/orthostatic-cardiovascular-profile-of-subjective-well-being
#1
Dmitry M Davydov, Róża Czabak-Garbacz
Previous clinical and elderly population studies have found that affective well-being can be assessed by clino-orthostatic cardiovascular reactivity. This study explored this relationship in a young healthy sample, and with respect to cognitive appraisals of well-being. Four successive readings of blood pressure (BP) and heart rate (HR) after lying down (clinostatic probe) followed by four successive readings after standing up (orthostatic probe) were obtained from 52 healthy students along with questionnaire-reported well-being...
November 28, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27792899/functional-alterations-of-root-meristematic-cells-of-arabidopsis-thaliana-induced-by-a-simulated-microgravity-environment
#2
Elodie Boucheron-Dubuisson, Ana I Manzano, Isabel Le Disquet, Isabel Matía, Julio Sáez-Vasquez, Jack J W A van Loon, Raúl Herranz, Eugénie Carnero-Diaz, F Javier Medina
Environmental gravity modulates plant growth and development, and these processes are influenced by the balance between cell proliferation and differentiation in meristems. Meristematic cells are characterized by the coordination between cell proliferation and cell growth, that is, by the accurate regulation of cell cycle progression and the optimal production of biomass for the viability of daughter cells after division. Thus, cell growth is correlated with the rate of ribosome biogenesis and protein synthesis...
October 19, 2016: Journal of Plant Physiology
https://www.readbyqxmd.com/read/27744595/simulated-microgravity-inhibits-the-migration-of-mesenchymal-stem-cells-by-remodeling-actin-cytoskeleton-and-increasing-cell-stiffness
#3
Xinjian Mao, Zhe Chen, Qing Luo, Bingyu Zhang, Guanbin Song
Exposure to microgravity during space flight affects almost all human physiological systems. Migration, proliferation, and differentiation of stem cells are crucial for tissues repair and regeneration. However, the effect of microgravity on the migration potentials of bone marrow mesenchymal stem cells (BMSCs) is unclear, which are important progenitor and supporting cells. Here, we utilized a clinostat to model simulated microgravity (SMG) and found that SMG obviously inhibited migration of rat BMSCs. We detected significant reorganization of F-actin filaments and increased Young's modulus of BMSCs after exposure to SMG...
December 2016: Cytotechnology
https://www.readbyqxmd.com/read/27444891/simulated-microgravity-inhibits-osteogenic-differentiation-of-mesenchymal-stem-cells-via-depolymerizing-f-actin-to-impede-taz-nuclear-translocation
#4
Zhe Chen, Qing Luo, Chuanchuan Lin, Dongdong Kuang, Guanbin Song
Microgravity induces observed bone loss in space flight, and reduced osteogenesis of bone mesenchymal stem cells (BMSCs) partly contributes to this phenomenon. Abnormal regulation or functioning of the actin cytoskeleton induced by microgravity may cause the inhibited osteogenesis of BMSCs, but the underlying mechanism remains obscure. In this study, we demonstrated that actin cytoskeletal changes regulate nuclear aggregation of the transcriptional coactivator with PDZ-binding motif (TAZ), which is indispensable for osteogenesis of bone mesenchymal stem cells (BMSCs)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27297199/risk-of-jugular-compression-blocks-in-workers-exposed-to-prolonged-upright-posture
#5
S De Sio, S Mandolesi, T Niglio, Aldo D'Alessandro, Alessandro D'Alessandro, A Vitarelli, S Ricci
BACKGROUND: The working posture affects the peripheral venous circulation, although the current literature does not report any correlation between working posture and the abnormalities of the jugular veins flow. The purpose of this preliminary research is to study, in female workers, the prevalence of Venous Compressive Syndrome (VCS) caused by total block of the internal jugular veins flow, so-called "White Compression". Due to complete compression by postural, muscular, fascial, anatomical or bone anomalies, White Compression is not visible by EchoColorDoppler (ECD) and its flow can only be detected by the rotational movements of the head or by Valsalva's maneuver...
May 2016: Annali di Igiene: Medicina Preventiva e di Comunità
https://www.readbyqxmd.com/read/27070587/melatonin-suppresses-autophagy-induced-by-clinostat-in-preosteoblast-mc3t3-e1-cells
#6
Yeong-Min Yoo, Tae-Young Han, Han Sung Kim
Microgravity exposure can cause cardiovascular and immune disorders, muscle atrophy, osteoporosis, and loss of blood and plasma volume. A clinostat device is an effective ground-based tool for simulating microgravity. This study investigated how melatonin suppresses autophagy caused by simulated microgravity in preosteoblast MC3T3-E1 cells. In preosteoblast MC3T3-E1 cells, clinostat rotation induced a significant time-dependent increase in the levels of the autophagosomal marker microtubule-associated protein light chain (LC3), suggesting that autophagy is induced by clinostat rotation in these cells...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27035921/simulated-microgravity-modulates-differentiation-processes-of-embryonic-stem-cells
#7
Vaibhav Shinde, Sonja Brungs, Margit Henry, Lucia Wegener, Harshal Nemade, Tamara Rotshteyn, Aviseka Acharya, Christa Baumstark-Khan, Christine E Hellweg, Jürgen Hescheler, Ruth Hemmersbach, Agapios Sachinidis
BACKGROUND/AIMS: Embryonic developmental studies under microgravity conditions in space are very limited. To study the effects of altered gravity on the embryonic development processes we established an in vitro methodology allowing differentiation of mouse embryonic stem cells (mESCs) under simulated microgravity within a fast-rotating clinostat (clinorotation) and capture of microarray-based gene signatures. METHODS: The differentiating mESCs were cultured in a 2D pipette clinostat...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26867611/assessing-gravitropic-responses-in-arabidopsis
#8
Richard Barker, Benjamin Cox, Logan Silber, Arash Sangari, Amir Assadi, Patrick Masson
Arabidopsis thaliana was the first higher organism to have its genome sequenced and is now widely regarded as the model dicot. Like all plants, Arabidopsis develops distinct growth patterns in response to different environmental stimuli. This can be seen in the gravitropic response of roots. Methods to investigate this particular tropism are presented here. First, we describe a high-throughput time-lapse photographic analysis of root growth and curvature response to gravistimulation allowing the quantification of gravitropic kinetics and growth rate at high temporal resolution...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26828798/the-impact-of-simulated-weightlessness-on-endothelium-dependent-angiogenesis-and-the-role-of-caveolae-caveolin-1
#9
Fei Shi, Tian-Zhi Zhao, Yong-Chun Wang, Xin-Sheng Cao, Chang-Bin Yang, Yuan Gao, Cheng-Fei Li, Jiang-Dong Zhao, Shu Zhang, Xi-Qing Sun
BACKGROUND/AIMS: The potential role of caveolin-1 in modulating angiogenesis in microgravity environment is unexplored. METHODS: Using simulated microgravity by clinostat, we measured the expressions and interactions of caveolin-1 and eNOS in human umbilical vein endothelial cells. RESULTS: We found that decreased caveolin-1 expression is associated with increased expression and phosphorylation levels of eNOS in endothelial cells stimulated by microgravity, which causes a dissociation of eNOS from caveolin-1 complexes...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26747275/cadmium-uptake-capacity-of-an-indigenous-cyanobacterial-strain-nostoc-entophytum-isc32-new-insight-into-metal-uptake-in-microgravity-simulating-conditions
#10
Leila Alidoust, Neda Soltani, Sima Modiri, Omid Haghighi, Aisan Azarivand, Khosro Khajeh, Hossein Shahbani Zahiri, Hojatollah Vali, Kambiz Akbari Noghabi
Among nine cyanobacterial strains isolated from oil-contaminated regions in southern Iran, an isolate with maximum cadmium uptake capacity was selected and identified on the basis of analysis of morphological criteria and 16S rRNA gene sequence similarity as Nostoc entophytum (with 99% similarity). The isolate was tentatively designated N. entophytum ISC32. The phylogenetic affiliation of the isolates was determined on the basis of their 16S rRNA gene sequence. The maximum amount of Cd(II) adsorbed by strain ISC32 was 302...
February 2016: Microbiology
https://www.readbyqxmd.com/read/26734055/a-bird-s-eye-view-of-molecular-changes-in-plant-gravitropism-using-omics-techniques
#11
REVIEW
Oliver Schüler, Ruth Hemmersbach, Maik Böhmer
During evolution, plants have developed mechanisms to adapt to a variety of environmental stresses, including drought, high salinity, changes in carbon dioxide levels and pathogens. Central signaling hubs and pathways that are regulated in response to these stimuli have been identified. In contrast to these well studied environmental stimuli, changes in transcript, protein and metabolite levels in response to a gravitational stimulus are less well understood. Amyloplasts, localized in statocytes of the root tip, in mesophyll cells of coleoptiles and in the elongation zone of the growing internodes comprise statoliths in higher plants...
2015: Frontiers in Plant Science
https://www.readbyqxmd.com/read/26729327/mood-disorders-in-uncontrolled-hypertension-despite-multiple-anti-hypertensive-medications-searching-for-a-link
#12
Alberto Mazza, Roberta Ravenni, Michela Armigliato, Ciro Rossetti, Laura Schiavon, Fulvio Fiorini, Gianluca Rigatelli, Emilio Ramazzina, Edoardo Casiglia
INTRODUCTION: Resistant hypertension is a clinical condition in which blood pressure (BP) control is not achieved under a pharmacological therapy including a diuretic and at least two additional antihypertensive drug classes. AIM: To discuss an unusual presentation of uncontrolled hypertension despite multiple anti-hypertensive medications. METHODS AND RESULTS: A 46-year-old woman presented with resistant hypertension (HT) and with a long history of polydipsia, polyuria, weight loss and psychiatric symptoms (sudden onset of personality disorder with free anxiety, negativism and asthenia) unsuccessfully treated with antidepressant drugs...
March 2016: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/26549225/simulated-microgravity-inhibits-osteogenic-differentiation-of-mesenchymal-stem-cells-through-down-regulating-the-transcriptional-co-activator-taz
#13
Zhe Chen, Qing Luo, Chuanchuan Lin, Guanbin Song
Microgravity induces observed bone loss in space flight or simulated experiments, while the mechanism underlying it is still obscure. Here, we utilized a clinostat to model simulated microgravity (SMG) and found that SMG obviously inhibited osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs). We detected that SMG dramatically inhibited the expression of the transcriptional coactivator with PDZ-binding motif (TAZ), which acts as a vital regulator of osteogenesis. Interestingly, we found that lysophosphatidic acid (LPA) could activate TAZ and retain osteogenic differentiation of BMSCs under SMG...
December 4, 2015: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/26496692/gravitropism-in-arabidopsis-thaliana-root-specific-action-of-the-ehb-gene-and-violation-of-the-resultant-law
#14
Michaela Dümmer, Christoph Forreiter, Paul Galland
Gravitropic bending of seedlings of Arabidopsis thaliana in response to centrifugal accelerations was determined in a range between 0.0025 and 4×g to revisit and validate the so-called resultant law, which claims that centrifugation causes gravitropic organs to orient parallel to the resultant stimulus vector. We show here for seedlings of A. thaliana that this empirical law holds for hypocotyls but surprisingly fails for roots. While the behavior of hypocotyls could be modeled by an arc tangent function predicted by the resultant law, roots displayed a sharp maximum at 1...
September 15, 2015: Journal of Plant Physiology
https://www.readbyqxmd.com/read/26388666/mnsod-downregulation-induced-by-extremely-low-0-1-mgy-single-and-fractionated-x-rays-and-microgravity-treatment-in-human-neuroblastoma-cell-line-nb-1
#15
Hiroko P Indo, Tsukasa Tomiyoshi, Shigeaki Suenaga, Kazuo Tomita, Hiromi Suzuki, Daisuke Masuda, Masahiro Terada, Noriaki Ishioka, Oleg Gusev, Richard Cornette, Takashi Okuda, Chiaki Mukai, Hideyuki J Majima
A human neuroblastoma cell line, NB-1, was treated with 24 h of microgravity simulation by clinostat, or irradiated with extremely small X-ray doses of 0.1 or 1.0 mGy using single and 10 times fractionation regimes with 1 and 2 h time-intervals. A quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) examination was performed for apoptosis related factors (BAX, CYTC, APAF1, VDAC1-3, CASP3, CASP8, CASP9 P53, AIF, ANT1 and 2, BCL2, MnSOD, autophagy related BECN and necrosis related CYP-40...
September 2015: Journal of Clinical Biochemistry and Nutrition
https://www.readbyqxmd.com/read/26274317/common-effects-on-cancer-cells-exerted-by-a-random-positioning-machine-and-a-2d-clinostat
#16
Benjamin Svejgaard, Markus Wehland, Xiao Ma, Sascha Kopp, Jayashree Sahana, Elisabeth Warnke, Ganna Aleshcheva, Ruth Hemmersbach, Jens Hauslage, Jirka Grosse, Johann Bauer, Thomas Juhl Corydon, Tawhidul Islam, Manfred Infanger, Daniela Grimm
In this study we focused on gravity-sensitive proteins of two human thyroid cancer cell lines (ML-1; RO82-W-1), which were exposed to a 2D clinostat (CLINO), a random positioning machine (RPM) and to normal 1g-conditions. After a three (3d)- or seven-day-culture (7d) on the two devices, we found both cell types growing three-dimensionally within multicellular spheroids (MCS) and also cells remaining adherent (AD) to the culture flask, while 1g-control cultures only formed adherent monolayers, unless the bottom of the culture dish was covered by agarose...
2015: PloS One
https://www.readbyqxmd.com/read/26177849/proper-selection-of-1-g-controls-in-simulated-microgravity-research-as-illustrated-with-clinorotated-plant-cell-suspension-cultures
#17
Khaled Y Kamal, Ruth Hemmersbach, F Javier Medina, Raúl Herranz
Understanding the physical and biological effects of the absence of gravity is necessary to conduct operations on space environments. It has been previously shown that the microgravity environment induces the dissociation of cell proliferation from cell growth in young seedling root meristems, but this source material is limited to few cells in each row of meristematic layers. Plant cell cultures, composed by a large and homogeneous population of proliferating cells, are an ideal model to study the effects of altered gravity on cellular mechanisms regulating cell proliferation and associated cell growth...
April 2015: Life Sciences in Space Research
https://www.readbyqxmd.com/read/25945103/effect-of-oenothera-odorata-root-extract-on-microgravity-and-disuse-induced-muscle-atrophy
#18
Yong-Hyeon Lee, Dong-Hyun Seo, Ji-Hyung Park, Kazuya Kabayama, Joerg Opitz, Kwang Ho Lee, Han-Sung Kim, Tack-Joong Kim
Muscle atrophy, a reduction of muscle mass, strength, and volume, results from reduced muscle use and plays a key role in various muscular diseases. In the microgravity environment of space especially, muscle atrophy is induced by muscle inactivity. Exposure to microgravity induces muscle atrophy through several biological effects, including associations with reactive oxygen species (ROS). This study used 3D-clinostat to investigate muscle atrophy caused by oxidative stress in vitro, and sciatic denervation was used to investigate muscle atrophy in vivo...
2015: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/25769184/modulation-of-modeled-microgravity-on-radiation-induced-bystander-effects-in-arabidopsis-thaliana
#19
Ting Wang, Qiao Sun, Wei Xu, Fanghua Li, Huasheng Li, Jinying Lu, Lijun Wu, Yuejin Wu, Min Liu, Po Bian
Both space radiation and microgravity have been demonstrated to have inevitable impact on living organisms during space flights and should be considered as important factors for estimating the potential health risk for astronauts. Therefore, the question whether radiation effects could be modulated by microgravity is an important aspect in such risk evaluation. Space particles at low dose and fluence rate, directly affect only a fraction of cells in the whole organism, which implement radiation-induced bystander effects (RIBE) in cellular response to space radiation exposure...
March 2015: Mutation Research
https://www.readbyqxmd.com/read/25661802/signal-transduction-in-primary-human-t-lymphocytes-in-altered-gravity-during-parabolic-flight-and-clinostat-experiments
#20
Svantje Tauber, Swantje Hauschild, Katrin Paulsen, Annett Gutewort, Christiane Raig, Eva Hürlimann, Josefine Biskup, Claudia Philpot, Hartwin Lier, Frank Engelmann, Antonella Pantaleo, Augusto Cogoli, Proto Pippia, Liliana E Layer, Cora S Thiel, Oliver Ullrich
BACKGROUND/AIMS: Several limiting factors for human health and performance in microgravity have been clearly identified arising from the immune system, and substantial research activities are required in order to provide the basic information for appropriate integrated risk management. The gravity-sensitive nature of cells of the immune system renders them an ideal biological model in search for general gravity-sensitive mechanisms and to understand how the architecture and function of human cells is related to the gravitational force and therefore adapted to life on Earth...
2015: Cellular Physiology and Biochemistry
keyword
keyword
95432
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"