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https://www.readbyqxmd.com/read/29670161/impact-of-three-different-mutations-in-ehrlichia-chaffeensis-in-altering-the-global-gene-expression-patterns
#1
Chandramouli Kondethimmanahalli, Roman Ganta
The rickettsial pathogen Ehrlichia chaffeensis causes a tick-borne disease, human monocytic ehrlichiosis. Mutations within certain genomic locations of the pathogen aid in understanding the pathogenesis and in developing attenuated vaccines. Our previous studies demonstrated that mutations in different genomic sites in E. chaffeensis caused variable impacts on their growth and attenuation in vertebrate and tick hosts. Here, we assessed the effect of three mutations on transcriptional changes using RNA deep-sequencing technology...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29668040/graft-loss-attributed-to-possible-transfusion-transmitted-ehrlichiosis-following-cord-blood-stem-cell-transplant
#2
A Mah, G M Viola, E Ariza Heredia, K Rezvani, P Kebriaei, M M Bhatti, X Han, E J Shpall, V Mulanovich
We present a case of possible transfusion-transmitted Ehrlichia chaffeensis infection in a heavily transfused cord blood transplant recipient, resulting in severe infection and graft loss. Transfusion-transmitted, vector-borne infections in immunocompromised individuals can have severe consequences, and should be considered in hospitalized patients receiving blood products with unexplained fever or sepsis. This article is protected by copyright. All rights reserved.
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29650038/a-lifelong-study-of-a-pack-rhodesian-ridgeback-dogs-reveals-subclinical-and-clinical-tick-borne-anaplasma-phagocytophilum-infections-with-possible-reinfection-or-persistence
#3
Emil Hovius, Arnout de Bruin, Leo Schouls, Joppe Hovius, Niels Dekker, Hein Sprong
BACKGROUND: Various tick-borne infections often occur without specific clinical signs and are therefore notoriously hard to diagnose separately in veterinary practice. Longitudinal studies over multiple tick seasons performing clinical, serological and molecular investigations in parallel, may elucidate the relationship between infection and disease. In this regard, six related Rhodesian Ridgeback dogs living as a pack became subject of lifetime studies due to ongoing tick infestations and recurring clinical problems...
April 12, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29643078/-ehrlichia-chaffeensis-trp75-interacts-with-host-cell-targets-involved-in-homeostasis-cytoskeleton-organization-and-apoptosis-regulation-to-promote-infection
#4
Tian Luo, Shubhajit Mitra, Jere W McBride
Ehrlichia chaffeensis is an obligately intracellular bacterium that exhibits tropism for mononuclear phagocytes. The mechanisms involved in E. chaffeensis infection of the host cell and evasion of host defenses are not fully defined, but a subset of type 1 secreted tandem repeat protein (TRP) effectors play important roles. Recently, we determined molecular interactions of TRP120, TRP47, and TRP32 with the eukaryotic host cell. In this investigation, we used yeast two-hybrid analysis to reveal that another E...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29580089/detection-and-molecular-characterisation-of-ehrlichia-canis-in-naturally-infected-dogs-in-south-west-nigeria
#5
Olukayode Olugbenga Daramola, Michael Irewole Takeet, Ibironke Kofoworola Oyewusi, Mufutau Atanda Oyekunle, Adewale Oladele Talabi
Canine ehrlichiosis is an important tick-borne rickettsial disease mainly caused by Ehrlichia canis. This study aimed to detect and characterise E. canis in dogs in Abeokuta, Nigeria by microscopy and nested PCR. Blood samples were collected from 205 dogs, thin smears were made, field-stained, and DNA was extracted from the blood samples. A partial region of the 16S rRNA gene was amplified by polymerase chain reaction (PCR) and sequenced unidirectionally. Ehrlichial morulae were detected in three dogs (1.5%)...
March 2018: Acta Veterinaria Hungarica
https://www.readbyqxmd.com/read/29496840/complete-genome-sequence-of-ehrlichia-canis-strain-yz-1-isolated-from-a-beagle-with-fever-and-thrombocytopenia
#6
Jilei Zhang, Jiawei Wang, Chengming Wang
We report the complete genome sequence of Ehrlichia canis strain YZ-1, which was isolated from a beagle with fever, anorexia, depression, lethargy, weight loss, and thrombocytopenia. E. canis is the tick-borne agent of canine and human monocytic ehrlichiosis.
March 1, 2018: Genome Announcements
https://www.readbyqxmd.com/read/29479151/detection-of-ehrlichia-anaplasma-and-babesia-spp-in-dogs-of-cebu-philippines
#7
Rochelle Haidee D Ybañez, Adrian P Ybañez, Lyra Lee A Arnado, Laila Monika P Belarmino, Knowlie Gay F Malingin, Paul Bien C Cabilete, Ziggy Ryan O Amores, Maxfrancis G Talle, Mingming Liu, Xuenan Xuan
Background: Ehrlichia , Anaplasma , and Babesia spp. are canine pathogens transmitted by the Rhipicephalus sanguineus tick which can cause varied clinical signs. These pathogens have been investigated in the Philippines, but coinfection has not been reported yet. Aim: The aim of this study was to evaluate the presence of Ehrlichia/Anaplasma and Babesia spp. in Philippine dogs. Materials and Methods: A total of 100 dogs from seven different veterinary establishments in Cebu, Philippines, were examined for Ehrlichia/Anaplasma and Babesia spp...
January 2018: Veterinary World
https://www.readbyqxmd.com/read/29406569/neospora-caninum-and-ehrlichia-canis-co-infection-in-a-dog-with-meningoencephalitis
#8
Itamar Aroch, Gad Baneth, Harold Salant, Yaarit Nachum-Biala, Asaf Berkowitz, Merav Shamir, Orit Chai
An 8-year-old mixed-breed dog was presented for acute, progressive weakness and ataxia, inappetence, and weight loss. The patient was mentally normal, but nonambulatory, with a right head tilt, right positional ventral strabismus, and slight head tremors. A neurologic lesion was localized to the cerebellum and right brainstem. Cerebrospinal fluid (CSF) analysis showed a markedly increased protein concentration and mixed pleocytosis, with eosinophil predominance (44%), intracytoplasmic inclusions within eosinophils, consistent with Ehrlichia canis (E canis) morulae, and Toxoplasma gondii (T gondii) or Neospora caninum (N caninum) tachyzoites within eosinophils and monocytes...
February 6, 2018: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/29398603/pathogen-transmission-in-relation-to-duration-of-attachment-by-ixodes-scapularis-ticks
#9
REVIEW
Lars Eisen
The blacklegged tick, Ixodes scapularis, is the primary vector to humans in the eastern United States of the deer tick virus lineage of Powassan virus (Powassan virus disease); the protozoan parasite Babesia microti (babesiosis); and multiple bacterial disease agents including Anaplasma phagocytophilum (anaplasmosis), Borrelia burgdorferi and Borrelia mayonii (Lyme disease), Borrelia miyamotoi (relapsing fever-like illness, named Borrelia miyamotoi disease), and Ehrlichia muris eauclairensis (a minor causative agent of ehrlichiosis)...
January 31, 2018: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29372907/solution-nmr-structures-of-oxidized-and-reduced-ehrlichia-chaffeensis-thioredoxin-nmr-invisible-structure-owing-to-backbone-dynamics
#10
Garry W Buchko, Stephen N Hewitt, Wesley C Van Voorhis, Peter J Myler
Thioredoxins are small ubiquitous proteins that participate in a diverse variety of redox reactions via the reversible oxidation of two cysteine thiol groups in a structurally conserved active site. Here, the NMR solution structures of a reduced and oxidized thioredoxin from Ehrlichia chaffeensis (Ec-Trx, ECH_0218), the etiological agent responsible for human monocytic ehrlichiosis, are described. The overall topology of the calculated structures is similar in both redox states and is similar to those of other thioredoxins: a five-stranded, mixed β-sheet (β1-β3-β2-β4-β5) surrounded by four α-helices...
January 1, 2018: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/29336985/the-blacklegged-tick-ixodes-scapularis-an-increasing-public-health-concern
#11
REVIEW
Rebecca J Eisen, Lars Eisen
In the United States, the blacklegged tick, Ixodes scapularis, is a vector of seven human pathogens, including those causing Lyme disease, anaplasmosis, babesiosis, Borrelia miyamotoi disease, Powassan virus disease, and ehrlichiosis associated with Ehrlichia muris eauclarensis. In addition to an accelerated rate of discovery of I. scapularis-borne pathogens over the past two decades, the geographic range of the tick, and incidence and range of I. scapularis-borne disease cases, have increased. Despite knowledge of when and where humans are most at risk of exposure to infected ticks, control of I...
April 2018: Trends in Parasitology
https://www.readbyqxmd.com/read/29202206/ehrlichia-and-anaplasma-infections-serological-evidence-and-tick-surveillance-in-peninsular-malaysia
#12
Fui Xian Koh, Kai Ling Kho, Masoumeh Ghane Kisomi, Li Ping Wong, Awang Bulgiba, Poai Ean Tan, Yvonne Ai Lian Lim, Quaza Nizamuddin Hassan Nizam, Chandrawathani Panchadcharam, Sun Tee Tay
Little information is available on human anaplasmosis and ehrlichiosis in Southeast Asia despite increasing reports of the detection of Anaplasma spp. and Ehrlichia spp. in the ticks. We report herein the serological findings against the tick-borne pathogens in a group of animal farm workers (n = 87) and indigenous people (n = 102) in Peninsular Malaysia. IgG antibodies against Ehrlichia chaffeensis were detected from 29.9% and 34.3% of farm workers and indigenous people, respectively, using commercial indirect immunofluorescence assays...
February 28, 2018: Journal of Medical Entomology
https://www.readbyqxmd.com/read/29162709/-ehrlichia-chaffeensis-and-its-invasin-etpe-block-reactive-oxygen-species-generation-by-macrophages-in-a-dnase-x-dependent-manner
#13
Omid Teymournejad, Mingqun Lin, Yasuko Rikihisa
The obligatory intracellular pathogen Ehrlichia chaffeensis lacks most genes that confer resistance to oxidative stress but can block reactive oxygen species (ROS) generation by host monocytes-macrophages. Bacterial and host molecules responsible for this inhibition have not been identified. To infect host cells, Ehrlichia uses the C terminus of its surface invasin, entry-triggering protein of Ehrlichia (EtpE; EtpE-C), which directly binds the mammalian cell surface receptor glycosylphosphatidylinositol-anchored protein DNase X...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29150636/a-genetic-system-for-targeted-mutations-to-disrupt-and-restore-genes-in-the-obligate-bacterium-ehrlichia-chaffeensis
#14
Ying Wang, Lanjing Wei, Huitao Liu, Chuanmin Cheng, Roman R Ganta
Obligate intracellular bacteria (obligates) belonging to Rickettsiales and Chlamydiales cause diseases in hundreds of millions of people worldwide and in many animal species. Lack of an efficient system for targeted mutagenesis in obligates remains a major impediment in understanding microbial pathogenesis. Challenges in creating targeted mutations may be attributed to essential nature of majority of the genes and intracellular replication dependence. Despite success in generating random mutations, a method that works well in creating mutations in specific genes of interest followed by complementation remains problematic for obligates and is a highly sought-after goal...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114125/prevalence-of-amblyomma-gervaisi-ticks-on-captive-snakes-in-tamil-nadu
#15
B R Catherine, M G Jayathangaraj, C Soundararajan, C Bala Guru, D Yogaraj
Ticks are the important ectoparasites that occur on snakes and transmit rickettsiosis, anaplasmosis and ehrlichiosis. A total of 62 snakes (Reticulated python, Indian Rock Python, Rat snakes and Spectacled cobra) were examined for tick infestation at Chennai Snake Park Trust (Guindy), Arignar Anna Zoological Park (Vandalur) and Rescue centre (Velachery) in Tamil Nadu from September, 2015 to June, 2016. Ticks from infested snakes were collected and were identified as Amblyomma gervaisi (previously known as Aponomma gervaisi )...
December 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/29042303/changes-in-serum-proteins-in-dogs-with-ehrlichia-canis-infection
#16
Damián Escribano, Hüseyin Cihan, Silvia Martínez-Subiela, Pinar Levent, Meric Kocaturk, Nilüfer Aytug, Jose Joaquin Cerón, Asta Tvarijonaviciute, Zeki Yilmaz
The aim of this study was the identification of proteins differentially represented in the serum proteome of seropositive dogs with (Group 1) and without (Group 2) clinical-pathologic signs consistent with ehrlichiosis compared to healthy control dogs. Serum samples were collected from 20 dogs of various breeds with naturally occurring ehrlichiosis (10 dogs belonged to Group 1 and 10 to Group 2) and 10 healthy dogs. Two-dimensional electrophoresis (2DE) of pooled serum for each of the group of dogs were run in triplicate...
December 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28943246/molecular-detection-and-phylogenetic-analysis-of-ehrlichia-canis-in-a-philippine-dog
#17
Naoya Maekawa, Satoru Konnai, Michelle M Balbin, Claro N Mingala, Karlo R B Gicana, Francis A E M Bernando, Shiro Murata, Kazuhiko Ohashi
Canine monocytic ehrlichiosis (CME), caused by a rickettsial bacterium, Ehrlichia canis, is distributed worldwide, particularly in tropical and subtropical regions. Transmission of E. canis is primarily mediated by the vector tick, Rhipicephalus sanguineus sensu lato and the bacteria then infect and replicate in monocytes and macrophages. Many cases are seen in veterinary hospitals and treated routinely; however, the genetic variation of E. canis strains found in the Philippines has been poorly investigated to date...
September 20, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28905983/-occurrence-of-ehrlichia-canis-in-dogs-living-in-germany-and-comparison-of-direct-and-indirect-diagnostic-methods
#18
Jacqueline Csokai, Eva Maria Klas, Anton Heusinger, Elisabeth Müller
OBJECTIVE: To study the occurrence of Ehrlichia (E.) canis in dogs living in Germany and evaluate the possibilities and limits of direct and indirect diagnostic methods. MATERIAL AND METHODS: The first part of the study was a retrospective analysis of routine samples, which had been examined for E. canis antibodies using an indirect immunofluorescence antibody test (IFAT). The examination was part of a laboratory profile for the detection of travel-related diseases (travel disease profile) or was performed on an individual basis...
September 13, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28846788/sudden-sensorineural-hearing-loss-in-human-monocytic-ehrlichiosis
#19
Vidur Bhalla, Brian Rodgers, James Lin
The hallmarks of symptomatic human monocytic ehrlichiosis (HME) include fever, headache, myalgia, nausea, malaise, transaminitis, and blood cell abnormalities. Previous case reports have described isolated cranial nerve palsies in infected patients but not hearing loss. We describe the onset of sudden sensorineural hearing loss in 2 patients with HME-a 31-year-old woman and an 82-year-old woman. The older patient experienced objective and subjective improvement in her hearing after treatment with an antibiotic and steroid taper; the younger patient was lost to audiologic follow-up...
August 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28751428/cerebral-haemorrhage-as-a-clinical-manifestation-of-human-ehrlichiosis
#20
Catalina Garc Ía-Baena, MarÍa Fernanda Cárdenas, Juan Fernando Ramón
A 16-year-old young man presented to the emergency room with new-onset generalised tonic-clonic seizures. Examination showed a Glasgow score of 13 and predominantly crural left hemiparesis. Imaging demonstrated a right frontoparietal haemorrhage of non-vascular origin with perilesional oedema. Surgical drainage was carried out, but rebleeding occurred within 24 hours following surgery, and again 1 week after discharge. On reinterrogation and examination, Ehrlichia canis infection was suspected and empirical management with doxycycline was begun...
July 27, 2017: BMJ Case Reports
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