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https://www.readbyqxmd.com/read/27929218/emerging-vector-borne-diseases
#1
Mark K Huntington, Jay Allison, Dilip Nair
Several mosquito-borne viral infections have recently emerged in North America; West Nile virus is the most common in the United States. Although West Nile virus generally causes a self-limited, flulike febrile illness, a serious neuroinvasive form may occur. Dengue is the most common vector-borne viral disease worldwide, and it has been a significant public health threat in the United States since 2009. Known as breakbone fever for its severe myalgias and arthralgias, dengue may cause a hemorrhagic syndrome...
October 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27914739/infection-by-mycobacterium-bovis-in-a-dog-from-brazil
#2
Vivianne Cambuí Figueiredo Rocha, Salomão Cambuí de Figueiredo, Cesar Alejandro Rodriguez Rosales, Camila Dias Porto, Julio Lopes Sequeira, José Soares Ferreira Neto, Antônio Carlos Paes, Vanessa Riesz Salgado
Tuberculosis (TB) is a chronic disease caused by bacteria belonging to the Mycobacterium tuberculosis complex (MtbC). This disease rarely affects dogs. Canine infections are usually caused by M. tuberculosis. Mycobacterium bovis infections are rare in dogs and associated with consumption of raw milk or contaminated products. Here, we report a Boxer dog who had a M. bovis infection and was admitted to a Brazilian veterinary hospital with a presumptive diagnosis of chronic ehrlichiosis. Despite receiving treatment for chronic ehrlichiosis, it progressed to death...
October 3, 2016: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/27898670/gray-wolf-exposure-to-emerging-vector-borne-diseases-in-wisconsin-with-comparison-to-domestic-dogs-and-humans
#3
Rocio F Jara, Adrian P Wydeven, Michael D Samuel
World-wide concern over emerging vector-borne diseases has increased in recent years for both animal and human health. In the United Sates, concern about vector-borne diseases in canines has focused on Lyme disease, anaplasmosis, ehrlichiosis, and heartworm which infect domestic and wild canids. Of these diseases, Lyme and anaplasmosis are also frequently diagnosed in humans. Gray wolves (Canis lupus) recolonized Wisconsin in the 1970s, and we evaluated their temporal and geographic patterns of exposure to these four vector-borne diseases in Wisconsin as the population expanded between 1985 and 2011...
2016: PloS One
https://www.readbyqxmd.com/read/27876946/evaluation-of-clinical-biochemical-and-haematological-markers-in-natural-infection-of-canine-monocytic-ehrlichiosis
#4
Rahul Parashar, Vikrant Sudan, Amit Kumar Jaiswal, Ashish Srivastava, Daya Shanker
Caanine monocytic ehrlichiosis caused by Ehrlichia canis has gained wider significance owing to its potential to inflict significant deleterious effect on the health of companion animals. In the present study, 46 confirmed ehrlichiosis positive dogs were evaluated for the alterations in clinical, haematological and biochemical attributes. Depression, anorexia, pyrexia, anaemia, weakness, jaundice, melana, vomition and diarrhoea were the main clinical symptoms onserved. Haematological alterations included pancytopenia especially thrombocytopenia...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27815656/efficacy-of-tagetes-minuta-asteraceae-essential-oil-against-rhipicephalus-sanguineus-acari-ixodidae-on-infested-dogs-and-in-vitro
#5
Elis Maressa Gonçalves da Silva, Vinicius da Silva Rodrigues, Jaciara de Oliveira Jorge, Carolina Fonseca Osava, Matias Pablo Juan Szabó, Marcos Valério Garcia, Renato Andreotti
Ticks from Rhipicephalus sanguineus complex are widely distributed in the world and one species from this complex is the most common tick on dogs in Brazil, notably in urban areas. This tick is a vector of several diseases. Among others it transmits the agent of canine Ehrlichiosis, a major dog infectious disease and the agent of Rocky Mountain spotted fever. This tick can spread rapidly and develop intolerable infestations within no time. Currently tick control is done with acaricides and demand for such drugs has grown fast...
November 4, 2016: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/27810200/cardiac-troponin-i-concentrations-electrocardiographic-and-echocardiographic-variables-remained-unchanged-in-dogs-experimentally-infected-with-ehrlichia-canis
#6
Lamprini Kalogianni, Christos K Koutinas, Konstantina Theodorou, Panagiotis G Xenoulis, Jan S Suchodolski, Shimon Harrus, Joerg M Steiner, Victoria I Siarkou, Mathios E Mylonakis
Canine monocytic ehrlichiosis (CME, Ehrlichia canis) has occasionally been associated with myocardial injury. The aim of the present study was to serially measure and evaluate cardiac troponin I (cTnI) concentrations in dogs with experimentally induced acute and subclinical CME and to evaluate potential associations between cTnI concentration and an array of echocardiographic and electrocardiographic parameters. Serum cTnI concentration and simultaneous echocardiographic and electrocardiographic recordings were evaluated in 12 healthy Beagle dogs prior to experimental infection and on days 20 and 90 post-inoculation with E...
November 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27758794/severe-human-monocytic-ehrlichiosis-presenting-with-altered-mental-status-and-seizures
#7
Christian Geier, Jessica Davis, Marc Siegel
A previously healthy 66-year-old woman living in the Mid-Atlantic USA presented to the hospital with lethargy, ataxia and slurred speech. 2 weeks prior she had removed a tick from her right groin. She reported malaise, fevers, diarrhoea, cough and a rash. Physical examination revealed a maculopapular rash on her chest, and lung auscultation revealed bi-basilar rales. Laboratory tests were remarkable for hyponatraemia, leucopenia and thrombocytopenia. Chest X-ray demonstrated bilateral pleural effusions with pulmonary oedema...
October 6, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27729288/amblyomma-americanum-ticks-infected-with-in-vitro-cultured-wild-type-and-mutants-of-ehrlichia-chaffeensis-are-competent-to-produce-infection-in-na%C3%A3-ve-deer-and-dogs
#8
Deborah C Jaworski, Chuanmin Cheng, Arathy D S Nair, Roman R Ganta
Monocytic ehrlichiosis in people caused by the intracellular bacterium, Ehrlichia chaffeensis, is an emerging infectious disease transmitted by the lone star tick, Amblyomma americanum. Tick transmission disease models for ehrlichiosis require at least two hosts and two tick blood feeding episodes to recapitulate the natural transmission cycle. One blood feeding is necessary for the tick to acquire the infection from an infected host and the next feeding is needed to transmit the bacterium to a naïve host...
January 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27633921/use-of-extracorporeal-support-in-hemophagocytic-lymphohistiocytosis-secondary-to-ehrlichiosis
#9
Amy Cheng, Feifei Williams, James Fortenberry, Catherine Preissig, Steven Salinas, Pradip Kamat
Ehrlichiosis, caused by transmission of Ehrlichia chaffeensis to humans through the bite of an infected lone star tick, can lead to secondary hemophagocytic lymphohistiocytosis (HLH), a life-threatening condition caused by uncontrolled activation of the cellular immune system. We describe a child with HLH secondary to ehrlichiosis who developed multiorgan failure and was successfully managed with extracorporeal membrane oxygenation (ECMO). A 9-year-old boy developed headaches, fever, and sore throat after suspected tick exposure...
September 15, 2016: Pediatrics
https://www.readbyqxmd.com/read/27585218/the-eye-and-tick-borne-disease-in-the-united-states
#10
Saraniya Sathiamoorthi, Wendy M Smith
PURPOSE OF REVIEW: Tick-borne diseases are increasing in incidence and geographic distribution. Several diseases endemic to the United States have ophthalmic manifestations, including the most common tick-borne disease, Lyme borreliosis. As ocular complaints may lead a patient to seek medical evaluation, it is important to be aware of the systemic and ophthalmic manifestations of tick-borne diseases in order to make the correct diagnosis. RECENT FINDINGS: Vision-threatening ophthalmic manifestations are relatively common in Lyme disease and Rocky Mountain spotted fever...
November 2016: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/27575459/human-monocytic-ehrlichiosis-complicated-by-hemophagocytic-lymphohistiocytosis-and-multi-organ-dysfunction-syndrome
#11
Rachel M Kaplan, Stanley A Swat, Benjamin D Singer
Human monocytic ehrlichiosis can manifest as a disease causing multi-organ failure. Rarely, it can cause secondary hemophagocytic lymphohistiocytosis (HLH). Early diagnosis and initiation of treatment for both ehrlichiosis and HLH is lifesaving. Therefore, clinical suspicion of HLH must remain high in the setting of an ehrlichiosis infection.
November 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27571570/canine-bicavitary-carcinomatosis-with-transient-needle-tract-metastasis-diagnosed-by-multiplex-immunocytochemistry
#12
A Russell Moore, Emily Coffey, Sarah E Leavell, Greta Krafsur, Colleen Duncan, Kristy Dowers, Kelly S Santangelo
A 6-year-old, male castrated, mixed-breed dog was referred to the James L. Voss Veterinary Teaching Hospital at Colorado State University for bicavitary effusion. On examination, the dog was tachycardic and tachypneic with bilaterally decreased lung sounds. Thoracic and abdominal ultrasonic examination revealed pleural and peritoneal effusions, which were aspirated and submitted for fluid analysis and cytology. Both cavity fluids were classified as exudates with a large population of vacuolated mononuclear cells...
September 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27541856/ehrlichia-secretes-etf-1-to-induce-autophagy-and-capture-nutrients-for-its-growth-through-rab5-and-class-iii-phosphatidylinositol-3-kinase
#13
Mingqun Lin, Hongyan Liu, Qingming Xiong, Hua Niu, Zhihui Cheng, Akitsugu Yamamoto, Yasuko Rikihisa
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes a potentially fatal emerging zoonosis, human monocytic ehrlichiosis. E. chaffeensis has a limited capacity for biosynthesis and metabolism and thus depends mostly on host-synthesized nutrients for growth. Although the host cell cytoplasm is rich with these nutrients, as E. chaffeensis is confined within the early endosome-like membrane-bound compartment, only host nutrients that enter the compartment can be used by this bacterium. How this occurs is unknown...
November 2016: Autophagy
https://www.readbyqxmd.com/read/27535678/molecular-survey-of-ehrlichia-canis-and-coxiella-burnetii-infections-in-wild-mammals-of-southern-italy
#14
Mario Santoro, Vincenzo Veneziano, Nicola D'Alessio, Francesca Di Prisco, Maria Gabriella Lucibelli, Giorgia Borriello, Anna Cerrone, Filipe Dantas-Torres, Maria Stefania Latrofa, Domenico Otranto, Giorgio Galiero
Ehrlichiosis and Q fever caused by the intracellular bacteria Ehrlichia canis and Coxiella burnetii, respectively, are tick-borne diseases with zoonotic potential and widespread geographical distribution. This study investigated the prevalence of both infections in wild mammals in southern Italy. Tissue samples obtained from the red fox (Vulpes vulpes), European badger (Meles meles), gray wolf (Canis lupus), beech marten (Martes foina), and crested porcupine (Hystrix cristata) were processed for molecular detection of both pathogens...
November 2016: Parasitology Research
https://www.readbyqxmd.com/read/27474020/countrywide-serological-evaluation-of-canine-prevalence-for-anaplasma-spp-borrelia-burgdorferi-sensu-lato-dirofilaria-immitis-and-ehrlichia-canis-in-mexico
#15
Rebeca Movilla, Carlos García, Susanne Siebert, Xavier Roura
BACKGROUND: Canine vector-borne diseases (CVBD) have become a major concern for canine and human public health. The aim of the study described here is to add epidemiological data regarding four pathogens responsible for CVBD, namely anaplasmosis, borreliosis, dirofilariosis and ehrlichiosis in a national survey conducted in Mexico. METHODS: Seventy-four veterinary centres located in 21 federal Mexican states were asked to test dogs with clinical signs suspect for CVBD and healthy dogs, for detection of Dirofilaria immitis antigen and antibodies against Anaplasma spp...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27430425/comparative-speed-of-kill-of-sarolaner-simparica%C3%A2-chewables-and-fluralaner-bravecto-%C3%A2-against-induced-infestations-of-amblyomma-americanum-on-dogs
#16
Robert H Six, David R Young, Melanie R Myers, Sean P Mahabir
BACKGROUND: The lone star tick, Amblyomma americanum, infests dogs and cats in North America and transmits the pathogens Ehrlichia chaffeensis and Ehrlichia ewingii, which cause monocytic and granulocytic ehrlichiosis in dogs and humans, and Cytauxzoon felis which causes cytauxzoonosis in cats. A parasiticide's speed of kill is important to minimize the direct deleterious effects [related to blood-feeding] of tick infestation and reduce the risk of transmission of tick-borne pathogens...
2016: Parasites & Vectors
https://www.readbyqxmd.com/read/27413287/ultrasonographic-changes-in-dogs-naturally-infected-with-tick-borne-intracellular-diseases
#17
Kalyan Sarma, D B Mondal, M Saravanan
Tick-borne infectious diseases constitute an emerging problem in Veterinary Medicine. The study was undertaken to find out the ultrasonographic changes of liver and spleen in 101 positive cases of tick borne intracellular haemoparasitic diseases in dogs. Abdominal survey of ultrasonography revealed hypo echogenicity of liver, gall bladder distension, splenomegaly, hepato-splenomegaly and ascites in various tick born intracellular diseases viz. ehrlichiosis, babesiosis, anaplasmosis, hepatozoonosis and in mixed infection...
June 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27402867/sequence-determinants-spanning-35-motif-and-at-rich-spacer-region-impacting-ehrlichia-chaffeensis-sigma-70-dependent-promoter-activity-of-two-differentially-expressed-p28-outer-membrane-protein-genes
#18
Huitao Liu, Laxmi U M R Jakkula, Tonia Von Ohlen, Roman R Ganta
Ehrlichia chaffeensis is an obligate intracellular tick-borne bacterium which causes the disease, human monocytic ehrlichiosis. Ehrlichia chaffeensis contains only two sigma factors, σ(32) and σ(70) It is difficult to study E. chaffeensis gene regulation due to lack of a transformation system. We developed an Escherichia coli-based transcription system to study E. chaffeensis transcriptional regulation. An E. coli strain with its σ(70) repressed with trp promoter is used to express E. chaffeensis σ(70) The E...
July 8, 2016: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/27388158/interstitial-pneumonia-and-pulmonary-hypertension-associated-with-suspected-ehrlichiosis-in-a-dog
#19
Marjolein Lisette den Toom, Tetyda Paulina Dobak, Els Marion Broens, Chiara Valtolina
BACKGROUND: In dogs with canine monocytic ehrlichiosis (CME), respiratory signs are uncommon and clinical and radiographic signs of interstitial pneumonia are poorly described. However, in human monocytic ehrlichiosis, respiratory signs are common and signs of interstitial pneumonia are well known. Pulmonary hypertension (PH) is classified based on the underlying disease and its treatment is aimed at reducing the clinical signs and, if possible, addressing the primary disease process...
2016: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/27381289/ehrlichia-chaffeensis-trp120-activates-canonical-notch-signaling-to-downregulate-tlr2-4-expression-and-promote-intracellular-survival
#20
Taslima T Lina, Paige S Dunphy, Tian Luo, Jere W McBride
UNLABELLED: Ehrlichia chaffeensis preferentially targets mononuclear phagocytes and survives through a strategy of subverting innate immune defenses, but the mechanisms are unknown. We have shown E. chaffeensis type 1 secreted tandem repeat protein (TRP) effectors are involved in diverse molecular pathogen-host interactions, such as the TRP120 interaction with the Notch receptor-cleaving metalloprotease ADAM17. In the present study, we demonstrate E. chaffeensis, via the TRP120 effector, activates the canonical Notch signaling pathway to promote intracellular survival...
2016: MBio
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