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Tavi review

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https://www.readbyqxmd.com/read/29746546/transcatheter-aortic-valve-implantation-for-aortic-stenosis-in-high-surgical-risk-patients-a-systematic-review-and-meta-analysis
#1
Zulian Liu, Elaine Kidney, Danai Bem, George Bramley, Susan Bayliss, Mark A de Belder, Carole Cummins, Rui Duarte
BACKGROUND: Symptomatic aortic stenosis has a poor prognosis. Many patients are considered inoperable or at high surgical risk for surgical aortic valve replacement (SAVR), reflecting their age, comorbidities and frailty. The clinical effectiveness and safety of TAVI have not been reviewed systematically for these high levels of surgical risk. This systematic review compares mortality and other important clinical outcomes up to 5 years post treatment following TAVI or other treatment in these risk groups...
2018: PloS One
https://www.readbyqxmd.com/read/29735584/bioprosthetic-aortic-valve-durability-in-the-era-of-transcatheter-aortic-valve-implantation
#2
REVIEW
Erwan Salaun, Marie-Annick Clavel, Josep Rodés-Cabau, Philippe Pibarot
The main limitation of bioprosthetic valves is their limited durability, which exposes the patient to the risk of aortic valve reintervention. Transcatheter aortic valve implantation (TAVI) is considered a reasonable alternative to surgical aortic valve replacement (SAVR) in patients with intermediate or high surgical risk. TAVI is now rapidly expanding towards the lower risk populations. Although the results of midterm durability of the transcatheter bioprostheses are encouraging, their long-term durability remains largely unknown...
May 7, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29724516/the-predictive-value-of-baseline-pulmonary-hypertension-in-early-and-long-term-cardiac-and-all-cause-mortality-after-transcatheter-aortic-valve-implantation-for-patients-with-severe-aortic-valve-stenosis-a-systematic-review-and-meta-analysis
#3
Damianos G Kokkinidis, Christos A Papanastasiou, Anil Kumar Jonnalagadda, Evangelos K Oikonomou, Christina A Theochari, Leonidas Palaiodimos, Haralambos I Karvounis, Ehrin J Armstrong, Robert T Faillace, George Giannakoulas
BACKGROUND: Transcatheter aortic valve implantation (TAVI) is a safe and effective alternative to surgical aortic valve replacement (SAVR) for the treatment of severe aortic valve stenosis (AS). The impact of concomitant baseline elevated pulmonary artery pressures on outcomes after TAVI has not been established, since different studies used different definitions of pulmonary hypertension (PH). OBJECTIVE: To determine the association of PH with early and late cardiac and all-cause mortality after TAVI...
March 23, 2018: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29709503/a-systemic-review-and-meta-analysis-of-sutureless-aortic-valve-replacement-versus-transcatheter-aortic-valve-implantation
#4
REVIEW
Sung Ho Shinn, Salah E Altarabsheh, Salil V Deo, Joseph H Sabik, Alan H Markowitz, Soon J Park
BACKGROUND: Suture-less and trans-catheter aortic valve implantation are increasingly adopted methods to treat high risk patients with severe aortic valve stenosis. We conducted a systematic review and meta-analysis to compare the clinical outcomes between the two recent methods to treat aortic valve disease. METHODS: We systematically searched multiple databases (January 2000-October 2016) to identify original studies comparing clinical outcome between suture-less (SU-AVR) and trans-catheter aortic valve implantation (TAVI)...
April 27, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29701365/long-term-outcomes-in-octogenarians-following-isolated-aortic-valve-replacement
#5
Sara Simões Costa, Diogo Rijo, João Pedro Monteiro, Daniel Martins, Nelson Santos Paulo, Luis Vouga, Miguel Guerra
INTRODUCTION: Isolated aortic valve replacement (AVR) in elderly patients is associated with increased operative risk, due to higher prevalence of associated risk factors and other comorbidities, making outcome prediction essential. In patients with symptomatic severe aortic disease, advanced age is often a reason for a transcatheter rather than surgical aortic valve replacement. In the era of TAVI, there has been renewed interest in the outcomes of conventional AVR for high and intermediate risk patients...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29656120/systemic-inflammatory-response-syndromes-in-the-era-of-interventional-cardiology
#6
REVIEW
Riccardo Gorla, Raimund Erbel, Kim A Eagle, Eduardo Bossone
Systemic inflammatory response syndrome (SIRS), initially reported after cardiovascular surgery, has been described after various interventional cardiology procedures, including endovascular/thoracic aortic repair (EVAR/TEVAR), implantation of heart rhythm devices, percutaneous coronary intervention (PCI), electrophysiology procedures (EP), and transcatheter aortic valve implantation (TAVI). In these settings, a comprehensive understanding of the triggers, pathogenesis as well as a common diagnostic/therapeutic algorithm is lacking and will be discussed in this review...
April 12, 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29622096/management-of-patients-with-aortic-valve-stenosis
#7
REVIEW
Amrit Kanwar, Jeremy J Thaden, Vuyisile T Nkomo
With increased life expectancy and aging of the population, aortic stenosis is now one of the most common valvular heart diseases. Early recognition and management of aortic stenosis are of paramount importance because untreated symptomatic severe disease is universally fatal. The advent of transcather aortic valve replacement technologies provides exciting avenues of care to patients with this disease in whom traditional surgical procedures could not be performed or were associated with high risk. This review for clinicians offers an overview of aortic stenosis and updated information on the current status of various treatment strategies...
April 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29593834/oral-anticoagulant-therapy-for-early-post-tavi-thrombosis
#8
Neil Ruparelia
While transcatheter aortic valve implantation (TAVI) is now the accepted treatment option of choice for patients presenting with severe symptomatic aortic stenosis who are deemed to be inoperable or of high surgical risk, there have been concerns regarding the risk of early valve failure and durability. One potential limitation is the occurrence of early post-TAVI thrombosis. Whilst the incidence of obstructive transcatheter heart valve (THV) thrombosis is <1 %, with technological advances in imaging, it is increasingly apparent that the overall true incidence is likely to be much higher with between 7-40 % of patients observed to have appearances strongly suggestive of asymptomatic subclinical THV thrombosis...
January 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29588739/predilatation-prior-to-transcatheter-aortic-valve-implantation-is-it-still-a-prerequisite
#9
Matteo Pagnesi, Luca Baldetti, Paolo Del Sole, Antonio Mangieri, Marco B Ancona, Damiano Regazzoli, Nicola Buzzatti, Francesco Giannini, Antonio Colombo, Azeem Latib
Predilatation has been historically considered a mandatory step before transcatheter aortic valve implantation (TAVI) since it facilitates valve crossing and prosthesis delivery, ensures optimal valve expansion and improves hemodynamic stability during valve deployment. However, as a result of procedural evolution over time, direct TAVI (without pre-implantation balloon aortic valvuloplasty) has emerged as an interesting option to simplify the procedure and to avoid potential valvuloplasty-related complications...
September 2017: Interventional Cardiology
https://www.readbyqxmd.com/read/29582947/-long-term-follow-up-of-transcatheter-self-expandable-aortic-valve-implantation
#10
Shmuel Chen, Vicky Zenios, Dan Gilon, David Planer, Ronen Beeri, Chaim Lotan, Haim D Danenberg
INTRODUCTION: Aortic stenosis is the most common significant valvular disease in the western world. These patients are treated operatively unless they are at high operative risk or inoperable. During the last decade an alternative approach has evolved - transcatheter aortic valve implantation (TAVI). This method was shown to be at least as effective and safe as the operative one. However, very little data exists on long term follow-up (5 years and above), especially regarding valve durability and patient survival...
March 2018: Harefuah
https://www.readbyqxmd.com/read/29578921/updated-clinical-indications-for-transcatheter-aortic-valve-implantation-in-patients-with-severe-aortic-stenosis-expert-opinion-of-the-italian-society-of-cardiology-and-gise
#11
Ciro Indolfi, Antonio L Bartorelli, Sergio Berti, Paolo Golino, Giovanni Esposito, Giuseppe Musumeci, Sonia Petronio, Corrado Tamburino, Giuseppe Tarantini, Gianpaolo Ussia, Corrado Vassanelli, Carmen Spaccarotella, Roberto Violini, Giuseppe Mercuro, Francesco Romeo
: The introduction of percutaneous treatment of severe aortic stenosis with transcatheter aortic valve implantation (TAVI) remains one of the greatest achievements of interventional cardiology. In fact, TAVI emerged as a better option than either medical therapy or balloon aortic valvuloplasty for patients who cannot undergo surgical aortic valve replacement (SAVR) or are at high surgical risk. Recently, increased operator experience and improved device systems have led to a worldwide trend toward the extension of TAVI to low-risk or intermediate-risk patients...
May 2018: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29565562/chemical-approaches-to-inhibiting-the-hepatitis-b-virus-ribonuclease-h
#12
John E Tavis, Grigoris Zoidis, Marvin J Meyers, Ryan P Murelli
Hepatitis B virus (HBV) chronically infects >250 million people and kills nearly a million annually, and current antivirals cannot clear the infection or adequately suppress disease. The virus replicates by reverse transcription, and the dominant antiviral drugs are nucleos(t)ide analogs that target the viral reverse transcriptase. We are developing antivirals targeting the other essential viral enzymatic activity, the ribonuclease H (RNaseH). HBV RNaseH inhibitors with efficacies in the low micromolar to nanomolar range against viral replication in culture have been identified in the α-hydroxytropolone and hydroxyimide chemotypes...
March 22, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29557590/what-are-the-remaining-limitations-of-tavi
#13
Chiara DE Biase, Antonios Mastrokostopoulos, Raphael Philippart, Laurent Bonfils, Pierre Berthoumieu, Nicolas Dumonteil
Transcatheter aortic valve implantation (TAVI) is a recognized therapy for patients with symptomatic severe aortic stenosis (AS). TAVI is superior compared to medical therapy as for mortality in extreme-risk patients, is non-inferior or superior to surgery in high- risk patients and non-inferior to surgery in intermediate-risk patients. However, several limitations affect outcomes after TAVI. Adverse events related to this procedure, like vascular complications, need forpacemaker implantation, paravalvular regurgitation, can be factors limiting TAVI treatment in younger patients at lower risk, as well as uncertainties regarding valve durability...
March 19, 2018: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/29541607/the-role-of-echocardiography-in-transcatheter-aortic-valve-implantation
#14
REVIEW
Toshinari Onishi, Kaoruko Sengoku, Yasuhiro Ichibori, Isamu Mizote, Koichi Maeda, Toru Kuratani, Yoshiki Sawa, Yasushi Sakata
Transcatheter aortic valve implantation (TAVI) is an effective and less invasive treatment for the increasing population of individuals with severe aortic stenosis (AS). Echocardiography is crucial in the assessment of AS patients from pre- to post-procedure. Transthoracic echocardiography (TTE) may be used to assess patient suitability for TAVI, as well as evaluate the severity of AS, the aortic valve complex, aortic valve morphology, mitral regurgitation (MR), and left ventricular function. Transesophageal echocardiography (TEE) is usually used as an intra-procedural monitoring tool to provide feedback during the procedure, to assess prosthetic valve function, and to detect complications rapidly before and after balloon aortic valvuloplasty (BAV) or transcatheter heart valve (THV) deployment...
February 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29508624/optimization-and-simplification-of-transcatheter-aortic-valve-implantation-therapy
#15
Marco Barbanti, Simona Gulino, Giuliano Costa, Corrado Tamburino
Transcatheter aortic valve implantation (TAVI) is now a widely adopted therapy for the treatment of elderly patients with severe aortic stenosis. Improved pre-procedural screening, increased operators' experience and technology advancement have made this technique highly reliable and standardized. Areas covered: The purpose of this review article is to provide an overview of the strategies that can be adopted to optimize the TAVI procedure (pre-interventional work-up and procedural simplification and early discharge)...
April 2018: Expert Review of Cardiovascular Therapy
https://www.readbyqxmd.com/read/29499894/transcarotid-transcatheter-aortic-valve-implantation-a-systematic-review
#16
REVIEW
Ian Jun Yan Wee, Thomas Stonier, Michael Harrison, Andrew M T L Choong
BACKGROUND: The carotid artery is a novel access route for transcatheter aortic valve implantation (TAVI), especially useful in patients unsuitable for traditional access routes including transfemoral (TF), subclavian, transapical (TAp), and aortic (TAo). This systematic review summarizes the evidence on TAVI via the carotid artery for its efficacy and safety. METHODS: A systematic review was conducted as per the Preferred Reporting Instructions for Systematic Reviews and Meta-analysis (PRISMA) guidelines on three online databases: Medline (via Pubmed), SCOPUS, and Cochrane Database...
June 2018: Journal of Cardiology
https://www.readbyqxmd.com/read/29434628/antithrombotic-therapy-in-tavi
#17
REVIEW
Manolis Vavuranakis, Konstantinos Kalogeras, Angelos Michail Kolokathis, Dimitrios Vrachatis, Nikolaos Magkoutis, Gerasimos Siasos, Euaggelos Oikonomou, Maria Kariori, Theodoros Papaioannou, Maria Lavda, Carmen Moldovan, Ourania Katsarou, Dimitrios Tousoulis
Transcatheter aortic valve implantation (TAVI) carries a significant thromboembolic and concomitant bleeding risk, not only during the procedure but also during the periprocedural period. Many issues concerning optimal antithrombotic therapy after TAVI are still under debate. In the present review, we aimed to identify all relevant studies evaluating antithrombotic therapeutic strategies in relation to clinical outcomes after the procedure. Four randomized control trials (RCT) were identified analyzing the post-TAVI antithrombotic strategy with all of them utilizing aspirin lifelong plus clopidogrel for 3-6 months...
January 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29428159/cerebral-protection-devices-during-transcatheter-aortic-valve-implantation
#18
REVIEW
Wieneke Vlastra, Jeroen Vendrik, Karel T Koch, Jan Baan, Jan J Piek, Ronak Delewi
Transcatheter aortic valve implantation (TAVI) in patients with aortic valve stenosis is associated with an improvement of clinical outcomes, quality of life, and self-sufficiency. The most feared TAVI-related complication is the occurrence of stroke. In order to reduce peri-procedural cerebral embolizations, diverse cerebral protection devices have been developed. These devices work though deflection or filtering of emboli, and are in different stages of testing. Silent cerebral infarctions identified by diffusion-weighted magnetic resonance imaging (DW-MRI) are used as surrogate primary outcomes, but the clinical significance is still unclear...
February 2, 2018: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29422266/right-ventricular-systolic-function-in-patients-undergoing-transcatheter-aortic-valve-implantation-a-systematic-review-and-meta-analysis
#19
Ben Ren, Ernest Spitzer, Marcel L Geleijnse, Felix Zijlstra, Peter P T de Jaegere, Nicolas M Van Mieghem, Jan G Tijssen
BACKGROUND: Right ventricular (RV) systolic dysfunction is associated with worse survival in patients undergoing surgical aortic valve replacement (SAVR), yet it is not included in traditional risk scores of transcatheter aortic valve implantation (TAVI) candidates. We aimed to evaluate the prognostic value of RV systolic function on clinical outcomes in patients undergoing TAVI at one year follow-up; and, echocardiographic changes of RV systolic function up to 12 months after TAVI and compared with SAVR when possible...
April 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29420704/pacemaker-implantation-rate-after-transcatheter-aortic-valve-implantation-with-early-and-new-generation-devices-a-systematic-review
#20
Philippe J van Rosendael, Victoria Delgado, Jeroen J Bax
Aims: The incidence of new-onset conduction abnormalities requiring permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation (TAVI) with new-generation prostheses remains debated. This systematic review analyses the incidence of PPI after TAVI with new-generation devices and evaluates the electrical, anatomical, and procedural factors associated with PPI. In addition, the incidence of PPI after TAVI with early generation prostheses was reviewed for comparison...
February 6, 2018: European Heart Journal
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