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Temperature regulation in brain injury

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https://www.readbyqxmd.com/read/27748880/alterations-in-the-expression-of-hs1-associated-protein-x-1-in-the-rat-retina-after-optic-nerve-crush
#1
Ling Cui, Wen-Jing He, Fan Xu, Li Jiang, Ming-Liang Lv, Hui Huang, Ji-Ping Xu, Yu Wu, Hai-Bin Zhong, Shao-Yang Zhang, Li-Fei Chen, Chao-Lan Shen, Gang Yao, Li Li, Min Li, Si-Ming Zeng
HS-1-associated protein X-1 (Hax-1) has been suggested to be expressed in various rodent and human tissues. Accumulating evidence has demonstrated that Hax‑1 exerts an anti‑apoptotic effect in neurological diseases. Furthermore, it has also been reported that Hax‑1 interacts with various apoptosis‑associated proteins, including high temperature-regulated A2 (HtrA2) and caspase‑3. Previous studies have indicated that abnormal expression of Hax‑1 may be associated with the development of the nervous system and with the pathophysiology of neurological diseases, including traumatic brain injury and cerebral ischemia...
October 11, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27591217/selective-head-cooling-during-neonatal-seizures-prevents-postictal-cerebral-vascular-dysfunction-without-reducing-epileptiform-activity
#2
Mimily Harsono, Massroor Pourcyrous, Elliott J Jolly, Amy de Jongh Curry, Alexander L Fedinec, Jianxiong Liu, Shyamali Basuroy, Daming Zhuang, Charles W Leffler, Helena Parfenova
Epileptic seizures in neonates cause cerebrovascular injury and impairment of cerebral blood flow (CBF) regulation. In the bicuculline model of seizures in newborn pigs, we tested the hypothesis that selective head cooling prevents deleterious effects of seizures on cerebral vascular functions. Preventive or therapeutic ictal head cooling was achieved by placing two head ice packs during the preictal and/or ictal states, respectively, for the ∼2-h period of seizures. Head cooling lowered the brain and core temperatures to 25...
November 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/27475000/neuroprotective-hypothermia-why-keep-your-head-cool-during-ischemia-and-reperfusion
#3
REVIEW
N Talma, W F Kok, C F de Veij Mestdagh, N C Shanbhag, H R Bouma, R H Henning
BACKGROUND: Targeted temperature management (TTM) is the induced cooling of the entire body or specific organs to help prevent ischemia and reperfusion (I/R) injury, as may occur during major surgery, cardiac resuscitation, traumatic brain injury and stroke. Ischemia and reperfusion induce neuronal damage by mitochondrial dysfunction and oxidative injury, ER stress, neuronal excitotoxicity, and a neuroinflammatory response, which may lead to activation of apoptosis pathways. SCOPE OF REVIEW: The aim of the current review is to discuss TTM targets that convey neuroprotection and to identify potential novel pharmacological intervention strategies for the prevention of cerebral ischemia and reperfusion injury...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27207589/using-the-icf-s-environmental-factors-framework-to-develop-an-item-bank-measuring-built-and-natural-environmental-features-affecting-persons-with-disabilities
#4
Allen W Heinemann, Jin-Shei Lai, Alex Wong, Jessica Dashner, Susan Magasi, Elizabeth A Hahn, Noelle E Carlozzi, David S Tulsky, Sara Jerousek, Patrick Semik, Ana Miskovic, David B Gray
OBJECTIVES: To develop a measure of natural environment and human-made change features (Chapter 2 of the international classification of functioning, disability, and health) and evaluate the influence of perceived barriers on health-related quality of life. METHODS: A sample of 570 adults with stroke, spinal cord injury, and traumatic brain injury residing in community settings reported their functioning in home, outdoor, and community settings (mean age = 47...
May 20, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27118366/-shaken-baby-syndrome
#5
W Reith, U Yilmaz, C Kraus
The shaken baby syndrome (SBS) or shaking trauma describes the occurrence of subdural hematoma, retinal hemorrhage and diffuse injury to the brain by vigorous shaking of an infant that has a poor prognosis. Rapid cranial acceleration and deceleration leads to tearing of bridging veins, retinal hemorrhages and diffuse brain injuries. In addition to clinical symptoms, such as irritability, feeding difficulties, somnolence, apathy, seizures, apnea and temperature regulation disorders, vomiting also occurs due to increased intracranial pressure...
May 2016: Der Radiologe
https://www.readbyqxmd.com/read/26995407/therapeutic-hypothermia-enhances-cold-inducible-rna-binding-protein-expression-and-inhibits-mitochondrial-apoptosis-in-a-rat-model-of-cardiac-arrest
#6
Lin Wu, He-Liang Sun, Yu Gao, Kang-Li Hui, Miao-Miao Xu, Hao Zhong, Man-Lin Duan
Therapeutic hypothermia is well known for its protective effect against brain injury after cardiac arrest, but the exact mechanism remains unclear. Cold-inducible RNA-binding protein (CIRP), a member of cold shock protein, enables mammalian cells to withstand decreased temperature by regulating gene translation. However, the role of CIRP in global cerebral ischemia after therapeutic hypothermia has not been clearly elucidated. In the present study, rats resuscitated from 4 min of cardiac arrest were separately treated with therapeutic hypothermia (immediately after return of spontaneous circulation (ROSC); targeted temperature at 33 °C) and therapeutic normothermia (targeted temperature at 36...
March 19, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26256480/highly-accurate-thermal-flow-microsensor-for-continuous-and-quantitative-measurement-of-cerebral-blood-flow
#7
Chunyan Li, Pei-ming Wu, Zhizhen Wu, Kanokwan Limnuson, Neal Mehan, Cameron Mozayan, Eugene V Golanov, Chong H Ahn, Jed A Hartings, Raj K Narayan
Cerebral blood flow (CBF) plays a critical role in the exchange of nutrients and metabolites at the capillary level and is tightly regulated to meet the metabolic demands of the brain. After major brain injuries, CBF normally decreases and supporting the injured brain with adequate CBF is a mainstay of therapy after traumatic brain injury. Quantitative and localized measurement of CBF is therefore critically important for evaluation of treatment efficacy and also for understanding of cerebral pathophysiology...
October 2015: Biomedical Microdevices
https://www.readbyqxmd.com/read/26140721/cerebral-vascular-control-and-metabolism-in-heat-stress
#8
REVIEW
Anthony R Bain, Lars Nybo, Philip N Ainslie
This review provides an in-depth update on the impact of heat stress on cerebrovascular functioning. The regulation of cerebral temperature, blood flow, and metabolism are discussed. We further provide an overview of vascular permeability, the neurocognitive changes, and the key clinical implications and pathologies known to confound cerebral functioning during hyperthermia. A reduction in cerebral blood flow (CBF), derived primarily from a respiratory-induced alkalosis, underscores the cerebrovascular changes to hyperthermia...
July 1, 2015: Comprehensive Physiology
https://www.readbyqxmd.com/read/26009172/control-of-translation-in-the-cold-implications-for-therapeutic-hypothermia
#9
REVIEW
John R P Knight, Anne E Willis
Controlled whole-body cooling has been used since the 1950s to protect the brain from injury where cerebral blood flow is reduced. Therapeutic hypothermia has been used successfully during heart surgery, following cardiac arrest and with varied success in other instances of reduced blood flow to the brain. However, why reduced temperature is beneficial is largely unknown. Here we review the use of therapeutic hypothermia with a view to understanding the underlying biology contributing to the phenomenon. Interestingly, the benefits of cooling have recently been extended to treatment of chronic neurodegenerative diseases in two mouse models...
June 2015: Biochemical Society Transactions
https://www.readbyqxmd.com/read/25725354/pharmacologically-induced-hypothermia-attenuates-traumatic-brain-injury-in-neonatal-rats
#10
Xiaohuan Gu, Zheng Zachory Wei, Alyssa Espinera, Jin Hwan Lee, Xiaoya Ji, Ling Wei, Thomas A Dix, Shan Ping Yu
Neonatal brain trauma is linked to higher risks of mortality and neurological disability. The use of mild to moderate hypothermia has shown promising potential against brain injuries induced by stroke and traumatic brain injury (TBI) in various experimental models and in clinical trials. Conventional methods of physical cooling, however, are difficult to use in acute treatments and in induction of regulated hypothermia. In addition, general anesthesia is usually required to mitigate the negative effects of shivering during physical cooling...
May 2015: Experimental Neurology
https://www.readbyqxmd.com/read/25686998/a-potent-inhibition-of-oxidative-stress-induced-gene-expression-in-neural-cells-by-sustained-ferulic-acid-release-from-chitosan-based-hydrogel
#11
Guo-Chung Dong, Che-Yung Kuan, Sadhasivam Subramaniam, Jiong-Yao Zhao, Savitha Sivasubramaniam, Hwan-You Chang, Feng-Huei Lin
Traumatic brain injury (TBI) is an extremely cataclysmic neurological disorder and the inhibition of oxidative stress following TBI could effectively protect the brain from further impairments. An injectable thermosensitive chitosan/gelatin/β-Glycerol phosphate (C/G/GP) hydrogel for the controlled release of the phenolic antioxidant ferulic acid (FA) to inhibit the neurological oxidative stress was demonstrated. The C/G/GP hydrogel ensures an excellent clinical expediency with a gelation temperature of 32...
April 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/25629821/acute-and-chronic-plasma-metabolomic-and-liver-transcriptomic-stress-effects-in-a-mouse-model-with-features-of-post-traumatic-stress-disorder
#12
Aarti Gautam, Peter D'Arpa, Duncan E Donohue, Seid Muhie, Nabarun Chakraborty, Brian T Luke, Dmitry Grapov, Erica E Carroll, James L Meyerhoff, Rasha Hammamieh, Marti Jett
Acute responses to intense stressors can give rise to post-traumatic stress disorder (PTSD). PTSD diagnostic criteria include trauma exposure history and self-reported symptoms. Individuals who meet PTSD diagnostic criteria often meet criteria for additional psychiatric diagnoses. Biomarkers promise to contribute to reliable phenotypes of PTSD and comorbidities by linking biological system alterations to behavioral symptoms. Here we have analyzed unbiased plasma metabolomics and other stress effects in a mouse model with behavioral features of PTSD...
2015: PloS One
https://www.readbyqxmd.com/read/25629055/d-aspartate-modulates-nociceptive-specific-neuron-activity-and-pain-threshold-in-inflammatory-and-neuropathic-pain-condition-in-mice
#13
Serena Boccella, Valentina Vacca, Francesco Errico, Sara Marinelli, Marta Squillace, Francesca Guida, Anna Di Maio, Daniela Vitucci, Enza Palazzo, Vito De Novellis, Sabatino Maione, Flaminia Pavone, Alessandro Usiello
D-Aspartate (D-Asp) is a free D-amino acid found in the mammalian brain with a temporal-dependent concentration based on the postnatal expression of its metabolizing enzyme D-aspartate oxidase (DDO). D-Asp acts as an agonist on NMDA receptors (NMDARs). Accordingly, high levels of D-Asp in knockout mice for Ddo gene (Ddo (-/-)) or in mice treated with D-Asp increase NMDAR-dependent processes. We have here evaluated in Ddo (-/-) mice the effect of high levels of free D-Asp on the long-term plastic changes along the nociceptive pathway occurring in chronic and acute pain condition...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25614675/-hypothermia-mechanism-of-action-and-pathophysiological-changes-in-the-human-body
#14
REVIEW
Przemysław Sosnowski, Kinga Mikrut, Hanna Krauss
This review focuses on the physiological responses and pathophysiological changes induced by hypothermia. Normal body function depends on its ability to maintain thermal homeostasis. The human body can be divided arbitrarily into two thermal compartments: a core compartment (trunk and head), with precisely regulated temperature around 37°C, and a peripheral compartment (skin and extremities) with less strictly controlled temperature, and lower than the core temperature. Thermoregulatory processes occur in three phases: afferent thermal sensing, central regulation, mainly by the preoptic area of the anterior hypothalamus, and efferent response...
2015: Postȩpy Higieny i Medycyny Doświadczalnej
https://www.readbyqxmd.com/read/25512189/a-wider-view-on-gastric-erosion-detailed-evaluation-of-complex-somatic-and-behavioral-changes-in-rats-treated-with-indomethacin-at-gastric-ulcerogenic-dose
#15
L P Filaretova, T R Bagaeva, O Y Morozova, D Zelena
OBJECTIVE: Gastric erosion is widespread side effect of nonsteroidal anti-inflammatory drugs. To examine the complexity of the brain-gut axis regulation, indomethacin-induced gastric erosion formation was studied in connection with somatic and behavioral changes. METHODS: During a constant telemetric recording of heart rate, body temperature, and locomotion of male rats we examined the effects of 24 h fasting, indomethacin (35 mg/kg s.c.) injection, and refeeding at 4 h...
October 2014: Endocrine Regulations
https://www.readbyqxmd.com/read/25501034/trpa1-is-essential-for-the-vascular-response-to-environmental-cold-exposure
#16
Aisah A Aubdool, Rabea Graepel, Xenia Kodji, Khadija M Alawi, Jennifer V Bodkin, Salil Srivastava, Clive Gentry, Richard Heads, Andrew D Grant, Elizabeth S Fernandes, Stuart Bevan, Susan D Brain
The cold-induced vascular response, consisting of vasoconstriction followed by vasodilatation, is critical for protecting the cutaneous tissues against cold injury. Whilst this physiological reflex response is historic knowledge, the mechanisms involved are unclear. Here by using a murine model of local environmental cold exposure, we show that TRPA1 acts as a primary vascular cold sensor, as determined through TRPA1 pharmacological antagonism or gene deletion. The initial cold-induced vasoconstriction is mediated via TRPA1-dependent superoxide production that stimulates α2C-adrenoceptors and Rho-kinase-mediated MLC phosphorylation, downstream of TRPA1 activation...
December 11, 2014: Nature Communications
https://www.readbyqxmd.com/read/25339859/brain-temperature-and-its-fundamental-properties-a-review-for-clinical-neuroscientists
#17
REVIEW
Huan Wang, Bonnie Wang, Kieran P Normoyle, Kevin Jackson, Kevin Spitler, Matthew F Sharrock, Claire M Miller, Catherine Best, Daniel Llano, Rose Du
Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although the impact of brain temperature is prevalent in a number of common human diseases including: head trauma, stroke, multiple sclerosis, epilepsy, mood disorders, headaches, and neurodegenerative disorders, it is evident and well recognized that the therapeutic application of induced hypothermia is limited to a few highly selected clinical conditions such as cardiac arrest and hypoxic ischemic neonatal encephalopathy...
2014: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/25248155/allopregnanolone-and-its-precursor-progesterone-do-not-reduce-injury-after-experimental-stroke-in-hypertensive-rats-role-of-postoperative-temperature-regulation
#18
Neil J Spratt, Amelia J Tomkins, Debbie Pepperall, Damian D McLeod, Mike B Calford
Allopregnanolone is a neurosteroid synthesized from progesterone in brain. It increases inhibition through modulation of the gamma-aminobutyric acid type A (GABA-A) receptor. Both agents are putative neuroprotectants after ischemic stroke. We sought to confirm their effectiveness in a hypertensive rat stroke model, with intra- and post-operative temperature regulation. The primary study compared allopregnanolone, progesterone or vehicle control treatments, administered 105 minutes after induction of temporary middle cerebral artery occlusion in spontaneously hypertensive rats...
2014: PloS One
https://www.readbyqxmd.com/read/25108738/effects-of-mild-and-moderate-hypothemia-therapy-on-expression-of-cerebral-neuron-apoptosis-related-proteins-and-glial-fiber-acidic-protein-after-rat-cardio-pulmonary-resuscitation
#19
COMPARATIVE STUDY
Li Ding, Xiang Gao, Shenghui Yu, Jianping Yang
To explore the effects of different degrees of hypothermia on brain tissue apoptosis after cardio-pulmonary resuscitation (CPR). Cardiac arrest for 5 min induced by asphyxia method was used to create CPR model. 30 SD rats were randomly divided into control group (normothermia), 33 °C hypothermia group and 30 °C hypothermia group with ten rats in each. Rats in control group received routine treatment at 25 °C room temperature after CPR; Rats in mild hypothermia and moderate hypothermia groups were given hypothermia treatment 0...
December 2014: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/25064786/hypothermia-as-a-clinical-neuroprotectant
#20
REVIEW
Andrew L Sherman, Michael Y Wang
Applying therapeutic hypothermia (TH) for the purposes of neuroprotection, originally termed "hibernation," started nearly 100 years ago. Because TH cooling systems have improved to the point where it is practical and safe for general application, interest in providing such treatment in conditions such as spinal cord injury, traumatic brain injury, stroke, and cardiac arrest has increased. This article reviews the mechanisms by which TH mitigates secondary neurologic injury, the clinical scenarios where TH is being applied, and reviews selected published studies using TH for central nervous system neuroprotection...
August 2014: Physical Medicine and Rehabilitation Clinics of North America
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