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mpMRI Prostate

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https://www.readbyqxmd.com/read/29770311/-super-active-surveillance-mri-ultrasound-fusion-biopsy-and-ablation-for-less-invasive-management-of-prostate-cancer
#1
REVIEW
Jonathan B Bloom, Samuel A Gold, Graham R Hale, Kareem N Rayn, Vikram K Sabarwal, Ivane Bakhutashvili, Vladimir Valera, Baris Turkbey, Peter A Pinto, Bradford J Wood
Multiparametric magnetic resonance imaging (mpMRI) of the prostate has allowed clinicians to better visualize and target suspicious lesions during biopsy. Targeted prostate biopsies give a more accurate representation of the true cancer volume and stage so that appropriate treatment or active surveillance can be selected. Advances in technology have led to the development of MRI and ultrasound fusion platforms used for targeted biopsies, monitoring cancer progression, and more recently for the application of focal therapy...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29770305/the-prostate-cancer-focal-therapy
#2
REVIEW
Filippo Pesapane, Francesca Patella, Enrico Maria Fumarola, Edoardo Zanchetta, Chiara Floridi, Gianpaolo Carrafiello, Chloë Standaert
Despite prostate cancer (PCa) is the leading form of non-cutaneous cancer in men, most patients with PCa die with disease rather than of the disease. Therefore, the risk of overtreatment should be considered by clinicians who have to distinguish between patients with high risk PCa (who would benefit from radical treatment) and patients who may be managed more conservatively, such as through active surveillance or emerging focal therapy (FT). The aim of FT is to eradicate clinically significant disease while protecting key genito-urinary structures and function from injury...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29753548/fusion-prostate-biopsy-outperforms-12-core-systematic-prostate-biopsy-in-patients-with-prior-negative-systematic-biopsy-a-multi-institutional-analysis
#3
Abhinav Sidana, Matthew J Watson, Arvin K George, Ardeshir R Rastinehad, Srinivas Vourganti, Soroush Rais-Bahrami, Akhil Muthigi, Mahir Maruf, Jennifer B Gordetsky, Jeffrey W Nix, Maria J Merino, Baris Turkbey, Peter L Choyke, Bradford J Wood, Peter A Pinto
INTRODUCTION AND OBJECTIVES: Patients with persistently elevated prostate specific antigen (PSA) and prior negative 12-core TRUS prostate biopsy (or biopsies) (systematic biopsy-SBx) are a diagnostic challenge. Repeat SBx or saturation biopsy in this cohort has been shown to have an even lower yield. The aim of our study is to compare the prostate cancer yield of magnetic resonance imaging (MRI) fusion biopsy (FBx) to SBx in a multi-institutional cohort comprised of patients with prior negative biopsies...
May 9, 2018: Urologic Oncology
https://www.readbyqxmd.com/read/29752647/multiparametric-magnetic-resonance-imaging-versus-partin-tables-and-the-memorial-sloan-kettering-cancer-center-nomogram-in-risk-stratification-of-patients-with-prostate-cancer-referred-to-external-beam-radiation-therapy
#4
Rossano Girometti, Martina Pancot, Marco Andrea Signor, Martina Urbani, Luca Balestreri, Chiara Zuiani
PURPOSE: To evaluate the agreement between multiparametric Magnetic Resonance Imaging (mpMRI), Partin tables (PT) and the Memorial Sloan Kettering Cancer Center nomogram (MSKCCn) in assessing risk category in prostate cancer (PCa) patients referred to External Beam Radiotherapy (EBRT). MATERIALS AND METHODS: In this bicentric study, we prospectively enrolled 80 PCa patients who underwent pre-EBRT mpMRI on a 3.0T magnet with a multiparametric protocol including high-resolution, multiplanar T2-weighted sequences, diffusion-weighted imaging and dynamic contrast-enhanced imaging...
May 12, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29750539/short-term-high-precision-radiotherapy-for-early-prostate-cancer-with-concomitant-boost-to-the-dominant-lesion-ad-interim-analysis-and-preliminary-results-of-phase-ii-trial-airc-ig-13218
#5
Giorgia Timon, Delia Ciardo, Alessia Bazani, Giulia Marvaso, Giulia Riva, Stefania Volpe, Stefania Volpe, Giuseppe Renne, Giuseppe Petralia, Dario Zerini, Damaris Patricia Rojas, Samantha Dicuonzo, Davide Maestri, Floriana Pansini, Raffaella Cambria, Cristiana Fodor, Federica Cattani, Federica Golino, Valerio Scroffi, Daniela De Lorenzo, Ottavio De Cobelli, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
OBJECTIVE: To report preliminary results of a cutting edge extreme hypofractionated treatment with concomitant boost to the dominant lesion for patients with early stage prostate cancer (PCa). METHODS: AIRC-IG-13218 is a prospective phase II trial started in June 2015. Patients with low and intermediate risk PCa who met the inclusion criteria underwent extreme hypofractionated radiotherapy to the prostate (36.25 Gy in 5 fractions) and a simultaneous integrated boost to the dominant intraprostatic lesion (DIL) to 37...
May 11, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29734177/multiparametric-magnetic-resonance-to-confirm-eligibility-to-an-active-surveillance-program-for-low-risk-prostate-cancer-intermediate-time-results-of-a-third-referral-high-volume-centre-active-surveillance-protocol
#6
Stefano Luzzago, Gennaro Musi, Michele Catellani, Andrea Russo, Ettore Di Trapani, Francesco Alessandro Mistretta, Roberto Bianchi, Gabriele Cozzi, Andrea Conti, Paola Pricolo, Matteo Ferro, Deliu-Victor Matei, Vincenzo Mirone, Giuseppe Petralia, Ottavio de Cobelli
BACKGROUND: To evaluate the role of confirmatory multiparametric magnetic resonance imaging (mpMRI) of the prostate at the time of Active Surveillance (AS) enrollment to reduce disease misclassification. MATERIALS: From 2012 to 2016, 383 patients with low-risk disease respecting Prostate Cancer Research International AS criteria underwent confirmatory 1.5-T mpMRI. AS was proposed to patients with Prostate Imaging and Report and Data System (PI-RADS) score ≤3 and no extraprostatic extension (EPE), whereas patients with PI-RADS score ≥4 and/or EPE were treated actively...
May 7, 2018: Urologia Internationalis
https://www.readbyqxmd.com/read/29733838/validation-of-pi-rads-version-2-for-the-detection-of-prostate-cancer
#7
Sebastian L Hofbauer, Beatrice Kittner, Andreas Maxeiner, Robin Heckmann, Maximillian Reimann, Laura Wiemer, Patrick Asbach, Matthias Haas, Tobias Penzkofer, Carsten Stephan, Frank Friedersdorff, Florian Fuller, Kurt Miller, Hannes Cash
PURPOSE: The second version of the Prostate Imaging Reporting and Data System (PI-RADSv2) was introduced in 2015 to standardize the interpretation and reporting of multiparametric prostate magnetic resonance imaging (mpMRI). Recently, low cancer detection rates (CDR) for PI-RADSv2 category 4 lesions were reported. Therefore the aim of the study was to evaluate the CDR of PI-RADSv2 in a large prospective cohort. METHODS: The study included 704 consecutive men with primary or prior negative biopsies who underwent MRI/ultrasound fusion-guided targeted biopsy (TB) and 10-core systematic prostate biopsy (SB) between September 2015 and May 2017...
May 4, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29733790/pi-rads-v2-current-standing-and-future-outlook
#8
REVIEW
Clayton P Smith, Barış Türkbey
The Prostate Imaging-Reporting and Data System (PI-RADS) was created in 2012 to establish standardization in prostate multiparametric magnetic resonance imaging (mpMRI) acquisition, interpretation, and reporting. In hopes of improving upon some of the PI-RADS v1 shortcomings, the PI-RADS Steering Committee released PI-RADS v2 in 2015. This paper reviews the accuracy, interobserver agreement, and clinical outcomes of PI-RADS v2 and comments on the limitations of the current literature. Overall, PI-RADS v2 shows improved sensitivity and similar specificity compared to PI-RADS v1...
May 2018: Turkish Journal of Urology
https://www.readbyqxmd.com/read/29732281/imaging-for-the-selection-and-monitoring-of-men-on-active-surveillance-for-prostate-cancer
#9
REVIEW
Maria C Velasquez, Nachiketh Soodana Prakash, Vivek Venkatramani, Bruno Nahar, Sanoj Punnen
Traditional prostate imaging is fairly limited, and only a few imaging modalities have been used for this purpose. Until today, grey scale ultrasound was the most widely used method for the characterization of the prostatic gland, however its limitations for prostate cancer (PCa) detection are well known and hence ultrasound is primarily used to localize the prostate and facilitate template prostate biopsies. In the past decade, multiparametric magnetic resonance imaging (mpMRI) of the prostate has emerged as a promising tool for the detection of PCa...
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29732280/expanded-criteria-for-active-surveillance-in-prostate-cancer-a-review-of-the-current-data
#10
REVIEW
Cameron Jones, Mina M Fam, Benjamin J Davies
Over the last ten years, active surveillance (AS) has become increasingly utilized for patients with low-risk prostate cancer. Appropriately selected AS patients have a 10-year prostate cancer-specific mortality (PCSM) approaching 99%. Therefore, some institutions have expanded the inclusion criteria for AS to avoid the unnecessary morbidity associated with overtreatment. In this review, data from several high-quality studies were compiled to demonstrate how AS inclusion criteria may be safely expanded. Although AS criteria, data reporting, and statistical methods were heterogeneous across studies, several findings were consistent and provided insight for clinical practice...
April 2018: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29730256/the-role-of-imaging-in-prostate-cancer-care-pathway-novel-approaches-to-urologic-management-challenges-along-ten-imaging-touch-points
#11
REVIEW
Qian Li, Feixiang Xiang, Xueying Lin, Joseph R Grajo, Long Yang, Yufeng Xu, Yu Duan, Urvi Vyas, Mukesh Harisinghani, Umar Mahmood, Anthony E Samir
We map out a typical prostate cancer care pathway through discussion of updates on modern imaging. Multiparametric MRI (mpMRI) is the most sensitive and specific imaging tool for diagnosis and local staging, transrectal ultrasound remains the most widely used technique for prostate biopsy guidance, CT and bone scan are useful in initial staging and recurrence detection. Novel imaging techniques in ultrasound elastography and mpMRI allow for increased lesion detection sensitivity and have the potential to enhance biopsy, while the development of new PET radiotracers has great promise for improved detection of local and metastatic disease in patients with biochemical recurrence...
May 3, 2018: Urology
https://www.readbyqxmd.com/read/29725743/3t-multiparametric-mr-imaging-piradsv2-based-detection-of-index-prostate-cancer-lesions-in-the-transition-zone-and-the-peripheral-zone-using-whole-mount-histopathology-as-reference-standard
#12
Nazanin Hajarol Asvadi, Sohrab Afshari Mirak, Amirhossein Mohammadian Bajgiran, Pooria Khoshnoodi, Pornphan Wibulpolprasert, Daniel Margolis, Anthony Sisk, Robert E Reiter, Steven S Raman
PURPOSE: To evaluate 3T mpMRI characteristics of transition zone and peripheral zone index prostate cancer lesions stratified by Gleason Score and PI-RADSv2 with whole mount histopathology correlation. METHODS: An institution review board-approved, HIPAA-compliant single-arm observational study of 425 consecutive men with 3T mpMRI prior to radical prostatectomy from December 2009 to October 2016 was performed. A genitourinary radiologist and a genitourinary pathologist matched all lesions detected on whole mount histopathology with lesions concordant for size and location on 3T mpMRI...
May 3, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29716617/focal-dose-escalation-for-prostate-cancer-using-68-ga-hbed-cc-psma-pet-ct-and-mri-a-planning-study-based-on-histology-reference
#13
Constantinos Zamboglou, Benedikt Thomann, Khodor Koubar, Peter Bronsert, Tobias Krauss, Hans C Rischke, Ilias Sachpazidis, Vanessa Drendel, Nasr Salman, Kathrin Reichel, Cordula A Jilg, Martin Werner, Philipp T Meyer, Michael Bock, Dimos Baltas, Anca L Grosu
BACKGROUND: Focal radiation therapy has gained of interest in treatment of patients with primary prostate cancer (PCa). The question of how to define the intraprostatic boost volume is still open. Previous studies showed that multiparametric MRI (mpMRI) or PSMA PET alone could be used for boost volume definition. However, other studies proposed that the combined usage of both has the highest sensitivity in detection of intraprostatic lesions. The aim of this study was to demonstrate the feasibility and to evaluate the tumour control probability (TCP) and normal tissue complication probability (NTCP) of radiation therapy dose painting using 68 Ga-HBED-CC PSMA PET/CT, mpMRI or the combination of both in primary PCa...
May 2, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29705281/a-multireader-exploratory-evaluation-of-individual-pulse-sequence-cancer-detection-on-prostate-multiparametric-magnetic-resonance-imaging-mri
#14
Sonia Gaur, Stephanie Harmon, Rajan T Gupta, Daniel J Margolis, Nathan Lay, Sherif Mehralivand, Maria J Merino, Bradford J Wood, Peter A Pinto, Joanna H Shih, Peter L Choyke, Baris Turkbey
RATIONALE AND OBJECTIVES: To determine independent contribution of each prostate multiparametric magnetic resonance imaging (mpMRI) sequence to cancer detection when read in isolation. MATERIALS AND METHODS: Prostate mpMRI at 3-Tesla with endorectal coil from 45 patients (n = 30 prostatectomy cases, n = 15 controls with negative magnetic resonance imaging [MRI] or biopsy) were retrospectively interpreted. Sequences (T2-weighted [T2W] MRI, diffusion-weighted imaging [DWI], and dynamic contrast-enhanced [DCE] MRI; N = 135) were separately distributed to three radiologists at different institutions...
April 25, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29702497/a-narrative-review-and-update-on-management-following-negative-prostate-biopsy
#15
Douglas C Cheung, Jenny Li, Antonio Finelli
PURPOSE OF REVIEW: Prostate cancer has traditionally been diagnosed using systematic transrectal ultrasound-guided biopsy. However, given the inherent nature of sampling, a negative biopsy does not exclude clinically significant prostate cancer (csPCa), and continued controversy exists in the optimal management following initial biopsy. Numerous avenues for evaluation include multiparametric MRI (mpMRI), use of molecular biomarkers, repeat biopsy, and observation. RECENT FINDINGS: mpMRI has shown promise in guiding further biopsy management: for individuals with identified target lesions, increased accuracy and detection using combination targeted and systematic sampling has been repeatedly demonstrated in the literature as an effective strategy...
April 26, 2018: Current Opinion in Urology
https://www.readbyqxmd.com/read/29699001/national-implementation-of-multi-parametric-mri-for-prostate-cancer-detection-recommendations-from-a-uk-consensus-meeting
#16
REVIEW
Mrishta Brizmohun Appayya, Jim Adshead, Hashim U Ahmed, Clare Allen, Alan Bainbridge, Tristan Barrett, Francesco Giganti, John Graham, Phil Haslam, Edward W Johnston, Christof Kastner, Alexander P S Kirkham, Alexandra Lipton, Alan McNeill, Larissa Moniz, Caroline M Moore, Ghulam Nabi, Anwar R Padhani, Chris Parker, Amit Patel, Jacqueline Pursey, Jonathan Richenberg, John Staffurth, Jan van der Meulen, Darren Walls, Shonit Punwani
OBJECTIVES: To identify areas of agreement and disagreement in the implementation of multi-parametric MRI (mpMRI) of the prostate in the diagnostic pathway. MATERIALS AND METHODS: Fifteen UK experts in prostate mpMRI and/or prostate cancer management across the UK (involving 9 NHS centres to provide for geographical spread) participated in a consensus meeting following the UCLA-RAND Appropriateness Method, and were moderated by an independent chair. The experts considered 354 items pertaining to who can request an mpMRI, prostate mpMRI protocol, reporting guidelines, training, quality assurance (QA) and patient management based on mpMRI levels of suspicion for cancer...
April 26, 2018: BJU International
https://www.readbyqxmd.com/read/29698083/voxel-wise-prostate-cell-density-prediction-using-multiparametric-magnetic-resonance-imaging-and-machine-learning
#17
Yu Sun, Hayley M Reynolds, Darren Wraith, Scott Williams, Mary E Finnegan, Catherine Mitchell, Declan Murphy, Annette Haworth
BACKGROUND: There are currently no methods to estimate cell density in the prostate. This study aimed to develop predictive models to estimate prostate cell density from multiparametric magnetic resonance imaging (mpMRI) data at a voxel level using machine learning techniques. MATERIAL AND METHODS: In vivo mpMRI data were collected from 30 patients before radical prostatectomy. Sequences included T2-weighted imaging, diffusion-weighted imaging and dynamic contrast-enhanced imaging...
April 26, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29685613/cognitive-versus-software-assisted-registration-development-of-a-new-nomogram-predicting-prostate-cancer-at-mri-targeted-biopsies
#18
Sascha Kaufmann, Giorgio I Russo, Wolfgang Thaiss, Mike Notohamiprodjo, Fabian Bamberg, Jens Bedke, Giuseppe Morgia, Konstantin Nikolaou, Arnulf Stenzl, Stephan Kruck
INTRODUCTION: Multiparametric magnetic resonance imaging (mpMRI) is gaining acceptance to guide targeted biopsy (TB) in prostate cancer (PC) diagnosis. We aimed to compare the detection rate of software-assisted fusion TB (SA-TB) versus cognitive fusion TB (COG-TB) for PC and to evaluate potential clinical features in detecting PC and clinically significant PC (csPC) at TB. PATIENTS AND METHODS: This was a retrospective cohort study of patients with rising and/or persistently elevated prostate-specific antigen (PSA) undergoing mpMRI followed by either transperineal SA-TB or transrectal COG-TB...
April 3, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29680949/local-staging-with-multiparametric-mri-in-daily-clinical-practice-diagnostic-accuracy-and-evaluation-of-a-radiologic-learning-curve
#19
B H E Jansen, F H K Oudshoorn, A M Tijans, M J Yska, A P Lont, E R P Collette, J A Nieuwenhuijzen, A N Vis
PURPOSE: To estimate the diagnostic accuracy of multiparametric MRI (mpMRI) for the detection of locally advanced prostate cancer (T-stage 3-4) prior to radical prostatectomy, in a multicenter cohort representing daily clinical practice. In addition, the radiologic learning curve for the detection of locally advanced disease is evaluated. METHODS: Preoperative mpMRI findings of 430 patients (2012-2016) were compared to pathology results following radical prostatectomy...
April 21, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29680007/the-disappearing-pi-rads-5-prostate-lesion
#20
Vikram K Sabarwal, Cayde Ritchie, Kareem Rayn, Baris Turkbey, Peter Pinto
Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) identifies prostate cancer on the basis of multiparametric MRI (mpMRI). As an assessment tool, it correctly predicts clinically significant cancer in the vast majority of cases. In this light, we report a rare patient, for whom a PI-RADS 5 lesion vanished over the course of 13 months.
April 2018: Canadian Journal of Urology
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