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Temperature regulation + paracetamol

B Csetényi, E Hormay, I Szabó, G Takács, B Nagy, K László, Z Karádi
In order to elucidate whether cytokine mechanisms of the cingulate cortex (cctx) are important in the central regulation of homeostasis, in the present study, feeding-metabolic effects of direct bilateral microinjection of interleukin-1β (IL-1β) into the cctx of the rat have been investigated. Short- (2h), medium (12h) and long-term (24h) food and water intakes and body temperature were measured after the intracerebral administration of this primary cytokine or vehicle solution, with or without paracetamol pretreatment...
July 28, 2017: Behavioural Brain Research
D Chiumello, M Gotti, G Vergani
Fever, which is arbitrary defined as an increase in body temperature above 38.3°C, can affect up to 90% of patients admitted in intensive care unit. Induction of fever is mediated by the release of pyrogenic cytokines (tumor necrosis factor α, interleukin 1, interleukin 6, and interferons). Fever is associated with increased length of stay in intensive care unit and with a worse outcome in some subgroups of patients (mainly neurocritically ill patients). Although fever can increase oxygen consumption in unstable patients, on the contrary, it can activate physiologic systems that are involved in pathogens clearance...
April 2017: Journal of Critical Care
Hugo Mendieta Zerón, Julio Cesar Arriaga García Rendon
After a brain injury, raised temperature may be due to a regulated readjustment in the hypothalamic 'set-point' in response to inflammation. The purpose of this report is to mention possible implications related to temperature and homeostasis of morphine treatment in a patient with brain injury. During the month previous to her hospitalization in our city she was treated for fever with paracetamol and metamizol without results. After 31 days with similar results, we changed to morphine IV considering the possibility of treating pain and fever...
January 2014: Le Journal Médical Libanais. the Lebanese Medical Journal
Alexis R Mauger, Lee Taylor, Christopher Harding, Benjamin Wright, Josh Foster, Paul C Castle
Acetaminophen (paracetamol) is a commonly used over-the-counter analgesic and antipyretic and has previously been shown to improve exercise performance through a reduction in perceived pain. This study sought to establish whether its antipyretic action may also improve exercise capacity in the heat by moderating the increase in core temperature. On separate days, 11 recreationally active participants completed two experimental time-to-exhaustion trials on a cycle ergometer in hot conditions (30°C, 50% relative humidity) after ingesting a placebo control or an oral dose of acetaminophen in a randomized, double-blind design...
January 2014: Experimental Physiology
Sebastiano A G Lava, Giacomo D Simonetti, Gian Paolo Ramelli, Sibylle Tschumi, Mario G Bianchetti
BACKGROUND: Symptomatic management is often all that is recommended in children with fever. To date, only 2 nationwide surveys of pediatricians regarding their attitudes toward fever have been published. OBJECTIVE: The aim of this study was to describe the management of children with fever by pediatricians in Switzerland. METHODS: For this survey, an initial close-ended questionnaire was tested and subsequently corrected. Between June 2010 and March 2011, an invitation was sent via electronic mail containing a link to the final version of the questionnaire...
January 2012: Clinical Therapeutics
Emilio Sánchez-Valdéz, Melissa Delgado-Aradillas, José Angel Torres-Martínez, José Martín Torres-Benítez
A dengue epidemic is one of the most important public health problems in the tropical and subtropical areas of the World. In 2005, 7,062 dengue cases were reported in Tamaulipas on Mexico's eastern coast, including 1,832 (26%) cases classified as Dengue Hemorrhagic Fever (DHF). Dengue fever (DF) is characterized by fever, intense headache, myalgias, arthralgias, rash, nausea and vomiting. A proportion of infected persons may develop DHF characterized by prominent hemorrhagic manifestations associated with thrombocytopenia...
2009: Proceedings of the Western Pharmacology Society
Bernd Kallmünzer, Christiane Krause, Elisabeth Pauli, Alexander Beck, Lorenz Breuer, Martin Köhrmann, Rainer Kollmar
BACKGROUND: Fever after acute cerebral injury is associated with unfavorable functional outcome and increased mortality, but there is controversy about the optimal antipyretic treatment. This study investigated an institutional standard operating procedure (SOP) for fever treatment in stroke patients including a sequence of pharmacologic and physical interventions. METHODS: A 4-step antipyretic SOP was established for patients with acute cerebral ischemia or hemorrhage and a body temperature ≥37...
2011: Cerebrovascular Diseases
Janne Fangel Jensen, Louise Lindhardt Tønnesen, Margareta Söderström, Hanne Thorsen, Volkert Siersma
OBJECTIVE: The sale of paracetamol products for children is increasing, and more children are accidentally given overdoses, even though the use of paracetamol against fever is still under discussion. This study explores Danish parents' use of paracetamol for feverish children and their motives for this use. DESIGN: A cross-sectional survey using structured interviews. Setting. Four general practices located in city, suburb, and rural area. SUBJECTS: A total of 100 Danish parents with at least one child under the age of 10 years...
June 2010: Scandinavian Journal of Primary Health Care
Gábor Takács, Szilárd Papp, Balázs Lukáts, Csaba Szalay, Bernadett Nagy, Dimitrios Fotakos, Zoltán Karádi
The present study investigates the effects of direct administration of interleukin-1beta (IL-1beta) into the nucleus accumbens (NAcc) on homeostatic regulation. Short- and long-term food intakes (FI), water intakes (WI) and body temperature (BT) were measured before and after bilateral microinjection of IL-1beta (with or without paracetamol pretreatment) into the NAcc of Wistar rats, and the effects were compared with those found in vehicle treated control animals. In addition, blood glucose levels, along with a glucose tolerance test (GTT), and plasma concentrations of metabolic parameters, such as total cholesterol, triglycerides, HDL, LDL and uric acid were determined in cytokine treated and control rats...
April 2010: Appetite
Balázs Lukáts, Róbert Egyed, László Lénárd, Zoltán Karádi
The present experiments were designed to elucidate the effect of direct orbitofrontal cortical administration of interleukin-1beta (IL-1beta) on the homeostatic regulation. Short- and long-term food intakes (FI), water intakes and body temperature (BT) were measured before and after a bilateral microinjection of IL-1beta (with or without paracetamol /P/ pretreatment) into the orbitofrontal cortex (OBF) of Wistar rats, and the effects were compared with those found in vehicle-treated and i.p. injected IL-1beta, IL-1beta+P or control animals...
October 2005: Appetite
Zoltán Karádi, Balázs Lukáts, Róbert Egyed, László Lénárd
To elucidate the homeostatic consequences of direct pallidal administration of interleukin-1beta (IL-1beta), short- (2 h) and long-term (12 h) food intakes, water intake and body temperature were measured after bilateral microinjection of IL-1beta (with or without paracetamol/PAR/pretreatment) into the ventro-medial part of the globus pallidus (GP). The effects were compared with those found in vehicle- or vehicle+PAR-treated control animals and intraperitoneally (i.p.) injected IL-1beta, IL-1beta+PAR or control rats...
April 2005: Appetite
Regina Botting
Low doses of aspirin reduce both pain and fever, whereas the anti-inflammatory action of aspirin requires a much higher dose. It is possible that inhibition of cyclooxygenase (COX)-1 is the major action of aspirin involved in its analgesic and antipyretic effects, and inhibition of COX-2 is responsible for its anti-inflammatory action. We compared the analgesic effects of an aspirin-like drug (diclofenac) and a centrally acting analgesic (paracetamol) in the mouse stretching test and confirmed that the analgesic action of the aspirin-like drug was peripheral...
June 15, 2003: Thrombosis Research
Eva Kokinsky, Eva Thornberg
Postoperative pain in children can usually be well controlled with a combination of analgesics, including acetaminophen (paracetamol), NSAIDs, opioids, and local/regional anesthesia. Recent research has shown that the dosage of acetaminophen required to provide analgesia is higher than the traditional dosages used for the regulation of elevated body temperature. Rectal administration of acetaminophen gives a lower and more variable bioavailability compared with oral administration. There is growing experience with the use of NSAIDs in children and several studies have demonstrated the relatively strong analgesic potential of these drugs...
2003: Paediatric Drugs
M Harrison
Diagnosis of fever is not necessarily simple. A variety of factors influence the decision to administer medication. The action of the antipyretic paracetamol is discussed in relation to practice issues. The importance of monitoring and recording fever is examined. The rationales for use of paracetamol are explored.
1998: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
N B Agbolosu, L E Cuevas, P Milligan, R L Broadhead, D Brewster, S M Graham
A block randomized clinical trial to compare the efficacy of tepid sponging with the use of paracetamol in febrile children was undertaken at the Queen Elizabeth Central Hospital, Blantyre. Eighty children aged between 6 and 54 months with axillary temperatures of between > or = 38.5 degrees C and < or = 40 degrees C and a clinical diagnosis consistent with upper respiratory tract infection and/or malaria were block randomized to receive either oral paracetamol (15 mg/kg) or tepid sponging. Children receiving tepid sponging were sponged from head to toe (except the scalp) by leaving a thin layer of water on the body...
September 1997: Annals of Tropical Paediatrics
M E Casterlin, W W Reynolds
1. Normothermic Cambarus bartoni crayfish thermoregulating behaviourally in an electronic shuttlebox prefer a mean temperature of 22.1 degrees C +/- 0.5 S.E. of mean. 2. Injection of 1% saline, or addition of paracetamol to the ambient water, caused a statistically insignificant decrease in preferred temperature of 0.4 degrees C. 3. Injection of killed Aeromonas hydrophila bacteria into the abdomen caused a significant mean increase in preferred temperature of 1.8 degrees C (defined as a behavioural fever)...
June 1980: Journal of Physiology
R Brus, Z S Herman, A Sokoła, B Zielińska
The effects of paracetamol and indomethacin on the action of centrally administered noradrenaline (NA) on the blood pressure, heart rate and rectal body temperature were studied in rats. It was demonstrated that both these substances increased NA effect on the arterial blood pressure and heart rate but caused no changes in NA effect on body temperature. These results suggest a modulating action of prostaglandins in the central nervous system on the functions of the centres regulating cardiovascular functions...
January 1981: Acta Physiologica Polonica
A S Milton, S Wendlandt
1. Prostaglandins were injected into the third ventricle of unanaesthetized cats and rabbits whilst rectal temperature was recorded.2. In cats prostaglandin E(1) and E(2) (PGE(1) and PGE(2)) produced hyperthermia which mostly began within a minute of injection and lasted 1 or more hours. With PGE(1) the hyperthermia was shown to be dose dependent between 10 ng and 10 mug (2.8 x 10(-11) and 2.8 x 10(-8)M). The hyperthermia was associated with vigorous shivering, skin vasoconstriction and piloerection. In several experiments a secondary rise in temperature occurred a few hours after the injection but such an effect was sometimes observed with control injections of 0...
October 1971: Journal of Physiology
M Jung, R Koppensteiner, W Graninger, H W Appel, F Lackner
Hypothermia is a rare complication of unknown origin in Hodgkin's disease which has been reported after the administration of antineoplastic agents, chlorpromazine and paracetamol. We report a highly febrile patient with stage IV-B Hodgkin's disease of mixed cellularity type who underwent exploratory laparotomy. Because of suspected septic shock high-dose prednisolone was given during surgery. Postoperatively the patient's body temperature fell progressively to 32.9 degrees C and remained at less then 35.5 degrees C for the following 5 days...
June 15, 1988: Klinische Wochenschrift
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