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Jennifer D Bowles, Amy J Jnah, Desi M Newberry, Carol A Hubbard, Tracey Roberston
BACKGROUND: The incidence of premature infants with complex medical needs, dependent upon medical technology at discharge, is on the rise in the United States. PURPOSE: Preparing the family for the hospital-to-home transition can be challenging due to the complex medical and emotional needs of the vulnerable infant and the volume of subspecialty services and equipment required. METHODS/SEARCH STRATEGY: Relevant articles from PubMed, Google Scholar, CINAHLFINDINGS/RESULTS:: There is an increasing incidence of technology dependent infants discharged from neonatal intensive care units in the United States...
December 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Alexis Jackson, Saumya Jani, Carol Davies Sala, Alfonso J C Soler-Bistué, Angeles Zorreguieta, Marcelo E Tolmasky
EGSs (external guide sequences) are short antisense oligoribonucleotides that elicit RNase P-mediated cleavage of a target mRNA, which results in inhibition of gene expression. EGS technology is used to inhibit expression of a wide variety of genes, a strategy that may lead to development of novel treatments of numerous diseases, including multidrug-resistant bacterial and viral infections. Successful development of EGS technology depends on finding nucleotide analogs that resist degradation by nucleases present in biological fluids and the environment but still elicit RNase P-mediated degradation when forming a duplex with a target mRNA...
March 2016: Biology Methods and Protocols
Jennifer Gillen, Marilyn Morris
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
Y Lehmann, M Ewers
Introduction: Over the past years, many home respiratory care services for invasively mechanically ventilated patients have been set up in Germany. However, little is known about the pathways used by these patients in order to access such specialized care. Methods: A qualitative, exploratory study was undertaken. Semi-structured interviews with 15 leading experts or employees responsible for care transition were conducted and subjected to content analysis. Results: Invasively ventilated patients' pathways into intensive home care tend to be highly random, risky and uncertain...
November 7, 2016: Das Gesundheitswesen
Corina Noje, Meghan L Bernier, Philomena M Costabile, Bruce L Klein, Sapna R Kudchadkar
OBJECTIVES: To present our single-center's experience with three palliative critical care transports home from the PICU for terminal extubation. DESIGN: We performed a retrospective chart review of patients transported between January 1, 2012, and December 31, 2014. SETTING: All cases were identified from our institutional pediatric transport database. PATIENTS: Patients were terminally ill children unable to separate from mechanical ventilation in the PICU, who were transported home for terminal extubation and end-of-life care according to their families' wishes...
October 28, 2016: Pediatric Critical Care Medicine
Wednesday Marie A Sevilla, Barbara McElhanon
Enteral nutrition is delivered via the gastrointestinal tract when oral intake is not sufficient to maintain nutrition status. There is evidence that long-term home enteral nutrition (HEN) can be advantageous to pediatric patients by improving quality of life and function. Data from pediatric patients receiving either nasogastric tube or gastrostomy tube feeds indicate good outcomes in terms of maintaining and improving nutrition status as evidenced by anthropometric measurements. As the number of pediatric patients requiring HEN increases, development of an effective program to allow smooth transition to the home is necessary...
October 18, 2016: Nutrition in Clinical Practice
Lina Marcela Silva-Bedoya, María Solange Sánchez-Pinzón, Gloria Ester Cadavid-Restrepo, Claudia Ximena Moreno-Herrera
The operation of wastewater treatment technologies depends on a combination of physical, chemical and biological factors. Microorganisms present in wastewater treatment plants play essential roles in the degradation and removal of organic waste and xenobiotic pollutants. Several microorganisms have been used in complementary treatments to process effluents rich in fats and oils. Microbial lipases have received significant industrial attention because of their stability, broad substrate specificity, high yields, and regular supply, as well as the fact that the microorganisms producing them grow rapidly on inexpensive media...
November 2016: Microbiological Research
Maverick W K Tsang
Stereotactic body radiotherapy (SBRT) has emerged as the standard treatment for medically inoperable early-staged non-small cell lung cancer (NSCLC). The local control rate after SBRT is over 90%. Some forms of tumour motion management and image-guided radiation delivery techniques are the prerequisites for fulfilment of its goal to deliver a high radiation dose to the tumour target without overdosing surrounding normal tissues. In this review, the current strategies of tumour motion management will be discussed, followed by an overview of various image-guided radiotherapy (RT) systems and devices available for clinical practice...
July 2016: Journal of Thoracic Disease
Aline Cristiane Cavicchioli Okido, Suelen Teles da Cunha, Eliane Tatsch Neves, Giselle Dupas, Regina Aparecida Garcia de Lima
OBJECTIVE: to understand the experience of mothers of technology-dependent children as regards pharmaceutical care. METHOD: this was a qualitative, descriptive-exploratory study developed based on open interviews using a structured characterization tool, and applied during home visits to 12 mothers caring for technology-dependent children. The data was submitted to inductive content analysis. RESULTS: this study is split into two themes: (i) maternal overload during pharmaceutical care, demonstrating the need to administer drugs continuously and the repercussions of this exhaustive care on the caregivers; (ii) the ease or difficulty of access to the medicines required, showing informal strategies and support networks...
May 2016: Revista Brasileira de Enfermagem
Douglas L Hill, Karen W Carroll, Dingwei Dai, Jennifer A Faerber, Susan L Dougherty, Chris Feudtner
BACKGROUND AND OBJECTIVES: Pediatric inpatients with communication impairment may experience inadequate pain and symptom management. Research regarding potential variation in care among patients with and without communication impairment is hampered because existing pediatric databases do not include information about patient communication ability per se, even though these data sets do contain information about diagnoses and medical interventions that are probably correlated with the probability of communication impairment...
August 2016: Hospital Pediatrics
Kaori Nishigaki, Yutaka Kanamori, Mari Ikeda, Masahiko Sugiyama, Hideko Minowa, Kiyoko Kamibeppu
PURPOSE: This research was conducted to reveal Japanese mothers' changing perceptions towards their technology-dependent children in the home care setting. METHODS: Fourteen Japanese mothers participated in semi-structured interviews, which were analyzed using a grounded theory approach. RESULTS: "Degree of preoccupation with the child" emerged as the category representing the mothers' perceptions towards their child. Three categories emerged that represented the progression of maternal perceptions over time: "accepting the child's conditions", "mastering the management of care in various conditions", and "considering social participation for the child"...
June 2016: Asian Nursing Research
Valerie Boebel Toly, Carol M Musil, Amy Bieda, Kimberly Barnett, Donna A Dowling, Abdus Sattar
BACKGROUND: Preterm neonates and neonates with complex conditions admitted to a neonatal intensive care unit (NICU) may require medical technology (eg, supplemental oxygen, feeding tubes) for their continued survival at hospital discharge. Medical technology introduces another layer of complexity for parents, including specialized education about neonatal assessment and operation of technology. The transition home presents a challenge for parents and has been linked with greater healthcare utilization...
July 13, 2016: Advances in Neonatal Care: Official Journal of the National Association of Neonatal Nurses
Yvonne Corcoran, Prof Owen Barr, Rosario Baxter
UNLABELLED: Theme: Complex health care and chronic disease management. INTRODUCTION: Increasing numbers of children with complex healthcare needs who are also dependent on medical technology are surviving and being cared for at home by their parents. AIM: To gain an in-depth understanding of the lives of parents and the impact of their caregiver role on their family when they care for their child at home. METHOD: An interpretative phenomenological design was deployed to interpret the narratives of sixteen parents through interviews and digital audio diaries...
May 9, 2016: Nursing Children and Young People
Lukas Marschall, Patrick Sagmeister, Christoph Herwig
Tuning of transcription is a powerful process technological tool for efficient recombinant protein production in Escherichia coli. Many challenges such as product toxicity, formation of inclusion bodies, cell death, and metabolic burden are associated with non-suitable (too high or too low) levels of recombinant protein expression. Tunable expression systems allow adjusting the recombinant protein expression using process technological means. This enables to exploit the cell's metabolic capacities to a maximum...
July 2016: Applied Microbiology and Biotechnology
Zayabalaradjane Zayapragassarazan, Santosh Kumar
INTRODUCTION: Telemedicine is an emerging technology in health sector in India. The success of any new technology depends on many factors including the knowledge and understanding of the concept, skills acquired, attitude towards technology and working environment by the concerned professionals. AIM: The main objective of this study was to assess the awareness, knowledge, attitude and skills of telemedicine among the health professionals working in the teaching hospitals of Puducherry Region of India...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
Karen A Horridge, Carl Harvey, Kenneth McGarry, Jane Williams, Gabriel Whitlingum, Mary Busk, Suzanne Fox, Gillian Baird, Andy Spencer
AIMS: To develop a Disabilities Terminology Set and quantify the multifaceted needs of disabled children and their families in a district disability clinic population. METHOD: Data from structured electronic clinic letters of children attending paediatric disability clinics from June 2007 to May 2012 in Sunderland, north-east England collected at the point of clinical care were analysed to determine appropriate terms for consistent recording of each need and issue...
June 2016: Developmental Medicine and Child Neurology
Aline Cristiane Cavicchioli Okido, Juliana Coelho Pina, Regina Aparecida Garcia Lima
OBJECTIVE: To identify the factors associated with involuntary hospital admissions of technology-dependent children, in the municipality of Ribeirão Preto, São Paulo State, Brazil. METHOD: A cross-sectional study, with a quantitative approach. After an active search, 124 children who qualified under the inclusion criteria, that is to say, children from birth to age 12, were identified. Data was collected in home visits to mothers or the people responsible for the children, through the application of a questionnaire...
February 2016: Revista da Escola de Enfermagem da U S P
O A Higuera-Barraza, C L Del Toro-Sanchez, S Ruiz-Cruz, E Márquez-Ríos
In recent years, high-energy ultrasound has been used as an alternative to improve the functional properties of various proteins, such as from milk, eggs, soy and poultry. The benefits of implementing this technology depend on the inherent characteristics of the protein source and the intensity and amplitude of the ultrasound, as well as on the pH, temperature, ionic strength, time, and all of the variables that have an effect on the physicochemical properties of proteins. Therefore, it is necessary to establish the optimal conditions for each type of food...
July 2016: Ultrasonics Sonochemistry
Michele A Mendes
A strategy based on the Hybrid Model of Concept Development was used to integrate previous concept analyses and research with data from interviews with parents and nurses caring for children dependent on technology to clarify the concept. Partnership was generally described positively in the literature, but some cautions were noted. Six characteristics of partnering were identified from the fieldwork data: respect, flexibility, caring professionalism, communication, acknowledgment of parental control, and support for parents...
January 2016: ANS. Advances in Nursing Science
Carmen Caicedo
This study describes health, functioning, and health care service use by medically complex technology-dependent children according to condition severity (moderately disabled, severely disabled, and vegetative state). Data were collected monthly for 5 months using the Pediatric Quality of Life Generic Core Module 4.0 Parent-Proxy Report. Health care service use measured the number of routine and acute care office visits (including primary and specialty physicians), emergency department visits, hospitalizations, nursing health care services, special therapies, medications, medical technology devices (MTDs), and assistive devices...
November 2016: Journal of Pediatric Health Care
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