keyword
https://read.qxmd.com/read/38496092/thinking-outside-the-box-a-case-of-persistent-symptomatic-hypomagnesemia
#1
Rita Relvas, Nuno Ferreira Monteiro, Rita Vale Rodrigues, Diogo Cruz
Although present in a significant number of people, hypomagnesemia is still an undervalued diagnosis. Therefore, its awareness and comprehensive etiological investigation become imperative. Among its multiple possible causes, drug iatrogenesis plays an important and often overlooked role. Here, we present a case of a 78-year-old female with recurrent bouts of severe hypomagnesemia of unknown origin, which, after an extensive study, was determined to be induced by proton pump inhibitors (PPIs). As such, our goal is to raise awareness of the potential risk of this side effect even in monotherapy, as well as to elucidate its underlying mechanisms, which are still not fully understood...
February 2024: Curēus
https://read.qxmd.com/read/38249234/evaluation-of-febrile-seizures-a-therapeutic-review-of-current-modalities
#2
REVIEW
Brinda Patel, Mokshit M Shah, Amrita Suresh, Parag N Patel, Priyansh Patel, Siddharth Kamal Gandhi
As benign as its nature is, a febrile seizure (FS) can be one of the most frightening experiences for parents to witness. It is a seizure that occurs in infants and children aged six months to five years, accompanied by a fever (with a temperature of at least 100.4°F or 38.0°C by any method), without any infection in the central nervous system. FS is typically benign and tends to resolve on its own. Overall, the risk of recurrence after an FS is high, so there is still a sizable knowledge discrepancy that needs to be addressed for better understanding and management of the disease...
December 2023: Curēus
https://read.qxmd.com/read/38152314/gabapentinoids-a-therapeutic-review
#3
REVIEW
Akshay Athavale, Bridin Murnion
The Australian Therapeutic Goods Administration's approved indications for prescription of gabapentinoids are refractory focal epilepsy and neuropathic pain. Use of gabapentinoids outside of the approved indications is common, but evidence for this is limited, especially for chronic nonspecific back pain and nonradicular leg pain. Some effects of gabapentinoids encourage their nonmedical use (e.g. euphoria, sedation, disinhibition). Widespread nonmedical use has increased the incidence of accidental and deliberate poisonings...
December 2023: Australian Prescriber
https://read.qxmd.com/read/38137864/collision-tumors-of-the-colon-and-peritoneum-signet-ring-cell-carcinoma-and-granular-cell-tumor
#4
Dorela-Codruta Lazureanu, Denisa Anderco, Sorin Dema, Aura Jurescu, Remus Cornea, Octavia Vita, Bogdan Tunescu, Sorina Taban
Collision tumors, although rare, characterized by two distinctive (morphological, as well immunohistochemical) and spatially independent tumor components at the same location, are always puzzling for clinicians, pathologists, and patients because they do not fit into the usual approaches, being neither diagnostic nor therapeutic. Reviewing the specialized literature, to date, collision tumors have been reported in multiple locations such as the skin, esophagus, stomach, intestine, liver, kidney, bladder, adrenal gland, or thyroid...
November 27, 2023: Life
https://read.qxmd.com/read/38006899/a-new-age-of-precision-gene-therapy
#5
REVIEW
Axel Schambach, Christian J Buchholz, Raul Torres-Ruiz, Klaus Cichutek, Michael Morgan, Ivana Trapani, Hildegard Büning
Gene therapy has become a clinical reality as market-approved advanced therapy medicinal products for the treatment of distinct monogenetic diseases and B-cell malignancies. This Therapeutic Review aims to explain how progress in genome editing technologies offers the possibility to expand both therapeutic options and the types of diseases that will become treatable. To frame these impressive advances in the context of modern medicine, we incorporate examples from human clinical trials into our discussion on how genome editing will complement currently available strategies in gene therapy, which still mainly rely on gene addition strategies...
November 22, 2023: Lancet
https://read.qxmd.com/read/37925369/rare-oncology-therapeutics-review-of-clinical-pharmacology-package-of-drug-approvals-2019-2023-by-us-fda-best-practices-and-recommendations
#6
REVIEW
Amitava Mitra, Jong Bong Lee, Douglas Steinbach, Anasuya Hazra, Rajesh Krishna
There are many challenges with rare diseases drug development and rare oncology indications are not different. To understand the regulatory landscape as it relates to application of clinical pharmacology principles in rare oncology product development, we reviewed publicly available information of 39 approvals by US FDA between January 2019 and March 2023. The objective was to understand the expected clinical pharmacology studies and knowledge base in such approvals. Model informed drug development (MIDD) applications were also reviewed, as such approaches are expected to play a critical role in filling clinical pharmacology gaps in rare oncology, where number of clinical trials and size of these trials will perhaps continue to be small...
November 4, 2023: Journal of Pharmacokinetics and Pharmacodynamics
https://read.qxmd.com/read/37859591/emerging-histological-and-serological-biomarkers-in-oral-squamous-cell-carcinoma-applications-in-diagnosis-prognosis-evaluation-and-personalized-therapeutics-review
#7
JOURNAL ARTICLE
Leonel Pekarek, Maria J Garrido-Gil, Alicia Sánchez-Cendra, Javier Cassinello, Tatiana Pekarek, Oscar Fraile-Martinez, Cielo García-Montero, Laura Lopez-Gonzalez, Antonio Rios-Parra, Melchor Álvarez-Mon, Julio Acero, Raul Diaz-Pedrero, Miguel A Ortega
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity and accounts for >90% of all oral cancers. Despite advances in diagnostic procedures and therapeutic interventions, overall survival has not improved significantly in recent decades, primarily due to late diagnosis, locoregional recurrence and treatment resistance. Identifying reliable biomarkers for early detection, prognosis evaluation and treatment response prediction is critical for improving clinical outcomes in patients with OSCC...
December 2023: Oncology Reports
https://read.qxmd.com/read/37598978/effect-and-mechanism-of-acupuncture-on-endogenous-and-exogenous-stem-cells-in-disease-treatment-a-therapeutic-review
#8
REVIEW
Hongyan Gao, Weijun Ding
Acupuncture is effective intervention, particularly in nerve, endocrine diseases and immune diseases. The potential mechanisms mediating the effects of acupuncture include anti-inflammatory and oxidative stress, inhibition of cell apoptosis, and stimulation of the proliferation and differentiation of endogenous stem cells. Traditional Chinese medicine combined with stem cell transplantation have a synergistic effect in the treatment of diseases. Increasing studies have found that acupuncture can promote the proliferation, differentiation, homing and survival of exogenous stem cells...
August 18, 2023: Life Sciences
https://read.qxmd.com/read/37556633/early-breast-cancer-concept-and-therapeutic-review
#9
JOURNAL ARTICLE
Maria Carolina Soliani Bastos, Aline Prado de Almeida, Fábio Bagnoli, Vilmar Marques de Oliveira
OBJECTIVE: Breast cancer treatment has evolved significantly over the years, both in terms of local and systemic approaches. Halsted's radical mastectomy gave way to modified mastectomies and to conservative surgeries, along with breast reconstruction and repair. Although the use of new drugs has directly increased the survival of patients submitted to adjuvant or neoadjuvant systemic therapies, the de-escalation of drugs may also be beneficial in numerous cases. Therefore, breast cancer treatment must be increasingly customized and assessed using a multidisciplinary approach...
2023: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/37353676/lennox-gastaut-syndrome-current-treatments-novel-therapeutics-and-future-directions
#10
JOURNAL ARTICLE
Julie A Nelson, Kelly G Knupp
Lennox-Gastaut syndrome is a severe drug-resistant developmental and epileptic encephalopathy with slow spike and wave on EEG (DEE-SSW) composing about 1-2% of epilepsy patients. Seizures in DEE-SSW are caused by a variety of etiologies, and there is a large unmet treatment need as seizures are usually treatment-resistant and individuals are often unable to function independently. The updated definition by the International League Against Epilepsy has established formal diagnostic criteria allowing for more uniform diagnosis...
June 23, 2023: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/37280158/therapeutic-review-the-role-of-tranexamic-acid-in-management-of-traumatic-brain-injury-nontraumatic-intracranial-hemorrhage-and-aneurysmal-subarachnoid-hemorrhage
#11
RANDOMIZED CONTROLLED TRIAL
Jana Sigmon, Kelli L Crowley, Christine M Groth
PURPOSE: To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice. SUMMARY: Intracranial hemorrhage, regardless of etiology, is associated with high morbidity and mortality. Tranexamic acid is an antifibrinolytic with anti-inflammatory properties shown to reduce mortality in trauma patients with extracranial injuries. In traumatic brain injury, a large randomized trial found no difference in outcomes when tranexamic acid was compared to placebo; however, subgroup analyses suggested that it may reduce head injury-related mortality in the context of mild-to-moderate injury if treatment occurs within 1 hour of symptom onset...
September 7, 2023: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/37111643/an-overview-of-the-stability-and-delivery-challenges-of-commercial-nucleic-acid-therapeutics
#12
REVIEW
Rahul G Ingle, Wei-Jie Fang
Nucleic acid (NA)-based biopharmaceuticals have emerged as promising therapeutic modalities. NA therapeutics are a diverse class of RNA and DNA and include antisense oligonucleotides, siRNA, miRNA, mRNA, small activating RNA, and gene therapies. Meanwhile, NA therapeutics have posed significant stability and delivery challenges and are expensive. This article discusses the challenges and opportunities for achieving stable formulations of NAs with novel drug delivery systems (DDSs). Here we review the current progress in the stability issues and the significance of novel DDSs associated with NA-based biopharmaceuticals, as well as mRNA vaccines...
April 6, 2023: Pharmaceutics
https://read.qxmd.com/read/37090073/drug%C3%A2-resistant-acinetobacter%C3%A2-baumannii-from-molecular-mechanisms-to-potential-therapeutics-review
#13
REVIEW
Hao-Jia Wu, Zhi-Gang Xiao, Xiao-Juan Lv, Hai-Tang Huang, Chu Liao, Chen-Yang Hui, Yue Xu, Heng-Fei Li
Bacterial drug resistance is increasingly becoming an important problem that needs to be solved urgently in modern clinical practices. Infection caused by Acinetobacter baumannii is a serious threat to the life and health of patients. The drug resistance rate of Acinetobacter baumannii strains is increasing, thus research on the drug resistance of Acinetobacter baumannii has also seen an increase. When patients are infected with drug-resistant Acinetobacter baumannii , the availability of suitable antibiotics commonly used in clinical practices is becoming increasingly limited and the prognosis of patients is worsening...
May 2023: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/36994248/mitigating-the-risk-of-drug-interactions-in-cancer-patients-taking-oral-anticancer-agents-the-role-of-a-multidisciplinary-team-based-medication-reconciliation
#14
JOURNAL ARTICLE
Jorge Rodrigues, Paula Marques, Catarina Gomes, Catarina Portela
PURPOSE: Polypharmacy in cancer patients is a recognized issue and should be an integral part of comprehensive patient assessment and management. Despite this, a systematic review of concomitant drugs or a search for potential drug-drug interactions (DDIs) is not always performed. Here, we present the results of a medication reconciliation model performed by a multidisciplinary team to identify clinically meaningful potential DDIs (defined by the presence of DDI of major severity or contraindication) in cancer patients undergoing oral antineoplastic drugs...
February 2023: Curēus
https://read.qxmd.com/read/36870691/up-regulated-circular-rnas-in-colorectal-cancer-new-entities-for-therapy-and-tools-for-identification-of-therapeutic-targets
#15
REVIEW
Ulrich H Weidle, Adam Nopora
Patients with disseminated colorectal cancer have a dismal prognosis with a 5-year survival rate of only 13%. In order to identify new treatment modalities and new targets, we searched the literature for up-regulated circular RNAs in colorectal cancer which induce tumor growth in corresponding preclinical in vivo models. We identified nine circular RNAs that mediate resistance against chemotherapeutic agents, seven that up-regulate transmembrane receptors, five that induce secreted factors, nine that activate signaling components, five which up-regulate enzymes, six which activate actin-related proteins, six which induce transcription factors and two which up-regulate the MUSASHI family of RNA binding proteins...
2023: Cancer Genomics & Proteomics
https://read.qxmd.com/read/36779088/modulation-of-burn-hypermetabolism-in-preclinical-models
#16
REVIEW
Abdullah S Eldaly, Francisco R Avila, Ricardo Torres, Karla Maita, John Garcia, Luiza Serrano, Olivia Ho, Antonio J Forte
Severe burns elicit a state of physiological stress and increased metabolism to help the body compensate for the changes associated with the traumatic injury. However, this hypermetabolic state is associated with increased insulin resistance, cardiovascular dysfunction, skeletal muscle catabolism, impaired wound healing, and delayed recovery. Several interventions were attempted to modulate burn hypermetabolism, including nutritional support, early excision and grafting, and growth hormone application. However, burn hypermetabolism still imposes significant morbidity and mortality in burn patients...
January 2023: Curēus
https://read.qxmd.com/read/36312971/-pseudomonas-aeruginosa-reference-strains-pao1-and-pa14-a-genomic-phenotypic-and-therapeutic-review
#17
REVIEW
Amber Grace, Rajnish Sahu, Donald R Owen, Vida A Dennis
Pseudomonas aeruginosa is a ubiquitous, motile, gram-negative bacterium that has been recently identified as a multi-drug resistant pathogen in critical need of novel therapeutics. Of the approximately 5,000 strains, PAO1 and PA14 are common laboratory reference strains, modeling moderately and hyper-virulent phenotypes, respectively. PAO1 and PA14 have been instrumental in facilitating the discovery of novel drug targets, testing novel therapeutics, and supplying critical genomic information on the bacterium...
2022: Frontiers in Microbiology
https://read.qxmd.com/read/36197593/antibody-drug-conjugates-in-non-small-cell-lung-cancer-emergence-of-a-novel-therapeutic-class
#18
REVIEW
Jennifer A Marks, Molly Wilgucki, Stephen V Liu, Joshua E Reuss
PURPOSE OF REVIEW: Antibody-drug conjugates (ADCs) are a class of therapeutics that combine target-specific monoclonal antibodies with cytotoxic chemotherapy. Here, we describe the components of ADCs and review their promising activity, safety, and applicability in non-small cell lung cancer (NSCLC). RECENT FINDINGS: Technological advancements have reinvigorated ADCs as a viable treatment strategy in advanced solid tumors. Several target-specific ADCs have shown promise in treatment-refractory NSCLC, including agents targeting HER2, HER3, TROP2, CEACAM5, and MET, among others, with multiple confirmatory phase 3 trials ongoing...
October 5, 2022: Current Oncology Reports
https://read.qxmd.com/read/35602778/esophageal-candidiasis-in-a-non-hiv-patient-a-primary-care-diagnosis
#19
Sofia Rodrigues, Vera Leitão Esteves, Teresa G Martins
A 74-year-old man visited his family doctor for dysphagia and was diagnosed with esophageal candidiasis. His risk factors included type 2 diabetes mellitus, long-term intake of budesonide/formoterol inhaler 160/45 µg, and pantoprazole 20 mg. He was treated with fluconazole 200 mg per day for 14 days. Other factors of immunosuppression were excluded, and his chronic medication was adapted by starting him with a proton pump inhibitor withdrawal plan and switching his inhaled device to a formoterol-only device without an inhaled corticosteroid...
April 2022: Curēus
https://read.qxmd.com/read/35505394/prescription-trends-at-the-end-of-life-in-a-palliative-care-unit-observational-study
#20
JOURNAL ARTICLE
Tatiana Peralta, Maria Margarida Castel-Branco, Paulo Reis-Pina, Isabel Vitória Figueiredo, Marília Dourado
BACKGROUND: Symptomatic control is essential in palliative care, particularly in end-of-life, in which the pathophysiological changes that characterize this last phase of life strengthen the need to carry out an early therapeutic review. Hence, we aim to evaluate the prescribing pattern at a palliative care unit at two different time points: on admission and the day of the patient's death. METHODS: Quantitative, analytic, longitudinal, retrospective and observational study...
May 4, 2022: BMC Palliative Care
keyword
keyword
9541
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.