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https://www.readbyqxmd.com/read/28647592/liposphere-mediated-topical-delivery-of-thymoquinone-in-the-treatment-of-psoriasis
#1
Anjali Jain, P Venkatesh, Upendra Bulbake, Sindhu Doppalapudi, Towseef Amin Rafeeqi, Chandraiah Godugu, Wahid Khan
Thymoquinone (TMQ) is reported with good anti-psoriatic activity however, the hydrophobicity, poor aqueous solubility, light and pH sensitive nature of TMQ hinder its delivery to target site. To address these delivery challenges of TMQ, lipospheres were explored. The topical use of lipospheres offer an effective mean of penetration along with stability and scalability. TMQ lipospheres of particle size below 70nm were prepared and evaluated. These lipospheres resulted in deeper skin penetration, slow release and skin compatibility...
June 21, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28647186/bougainvillea-spectabilis-flowers-extract-protects-against-the-rotenone-induced-toxicity
#2
Omar M E Abdel-Salam, Eman R Youness, Nadia A Ahmed, Sayed A El-Toumy, Ahmed M A Souleman, Nermeen Shaffie, Dalia M Abouelfadl
OBJECTIVE: To investigate the effect of two extracts of Bougainvillea spectabilis (B. spectabilis) flowers with yellow and pink/purple on brain oxidative stress and neuronal damage caused in rats by systemic rotenone injection. METHODS: Rotenone 1.5 mg/kg was given three times per week alone or in combination with B. spectabilis flowers extracts (25 mg or 50 mg) via the subcutaneous route for 2 weeks. Brain concentrations of the lipid peroxidation marker malondialdehyde (MDA), reduced glutathione, nitric oxide (nitrite), the pro-inflammatory cytokine interleukin-1beta (Il-1β) as well as butyrylcholinesterase, and paraoxonase-1 (PON-1) activities, were determined...
May 2017: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/28646156/mahanine-exerts-in-vitro-and-in-vivo-antileishmanial-activity-by-modulation-of-redox-homeostasis
#3
Saptarshi Roy, Devawati Dutta, Eswara M Satyavarapu, Pawan K Yadav, Chhabinath Mandal, Susanta Kar, Chitra Mandal
Earlier we have established a carbazole alkaloid (mahanine) isolated from an Indian edible medicinal plant as an anticancer agent with minimal effect on normal cells. Here we report for the first time that mahanine-treated drug resistant and sensitive virulent Leishmania donovani promastigotes underwent apoptosis through phosphatidylserine externalization, DNA fragmentation and cell cycle arrest. An early induction of reactive oxygen species (ROS) suggests that the mahanine-induced apoptosis was mediated by oxidative stress...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28646032/the-human-coronary-vasodilatory-response-to-acute-mental-stress-is-mediated-by-neuronal-nitric-oxide-synthase
#4
Sitara Gulurkh Khan, Narbeh Melikian, Husain Shabeeh, Ana Rita Cabaco, Katherine Martin, Faisal Khan, Kevin O'Gallagher, Phil Chowienczyk, Ajay M Shah
INTRODUCTION: Mental stress-induced ischemia approximately doubles the risk of cardiac events in patients with coronary artery disease, yet the mechanisms underlying changes in coronary blood flow in response to mental stress are poorly characterized. Neuronal nitric oxide synthase (nNOS) regulates basal coronary blood flow in healthy humans and mediates mental stress-induced vasodilation in the forearm. However, its possible role in mental-stress-induced increases in coronary blood flow is unknown...
June 23, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28645930/genomic-and-non-genomic-effects-of-androgens-in-the-cardiovascular-system-clinical-implications
#5
REVIEW
Angela K Lucas Herald, Rheure Alves-Lopes, Augusto C Montezano, S Faisal Ahmed, Rhian M Touyz
The principle steroidal androgens are testosterone and its metabolite 5α-dihydrotestosterone (DHT), which is converted from testosterone by the enzyme 5α-reductase. Through the classic pathway with androgens crossing the plasma membrane and binding to the androgen receptor (AR) or via mechanisms independent of the ligand-dependent transactivation function of nuclear receptors, testosterone induces genomic and non-genomic effects respectively. AR is widely distributed in several tissues, including vascular endothelial and smooth muscle cells...
July 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28645873/generation-of-nitric-oxide-by-olive-olea-europaea-l-pollen-during-in-vitro-germination-and-assessment-of-the-s-nitroso-and-nitro-pollen-proteomes-by-computational-predictive-methods
#6
María José Jimenez-Quesada, Rosario Carmona, Elena Lima-Cabello, José Ángel Traverso, Antonio Jesús Castro, M Gonzalo Claros, Juan de Dios Alché
Nitric oxide is recognized as a signaling molecule involved in a broad range of physiological processes in plants including sexual reproduction. NO has been detected in the pollen grain at high levels and regulates pollen tube growth. Previous studies demonstrated that NO as well as ROS are produced in the olive reproductive tissues in a stage- and tissue-specific manner. The aim of this study was to assess the production of NO throughout the germination of olive (Olea europaea L.) pollen in vitro. The NO fluorescent probe DAF-2DA was used to image NO production in situ, which was correlated to pollen viability...
June 20, 2017: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/28645860/gper-agonist-dilates-mesenteric-arteries-via-pi3k-akt-enos-and-potassium-channels-in-both-sexes
#7
Pollyana Peixoto, Rosária Dias Aires, Virgínia Soares Lemos, Nazaré Souza Bissoli, Roger Lyrio Dos Santos
AIM: The action of oestrogen has traditionally been attributed to the activation of nuclear receptors (ERα and ERβ). A third receptor, the G protein-coupled oestrogen receptor (GPER), has been described as mediator of the rapid action of oestrogen. Based on the possible protective role of oestrogen in the cardiovascular system, the present study was designed to determine whether selective GPER activation induces relaxation of mesenteric resistance arteries in both sexes and which signalling pathways are involved...
June 20, 2017: Life Sciences
https://www.readbyqxmd.com/read/28645771/dectin-1-expression-by-macrophages-and-related-antifungal-mechanisms-in-a-murine-model-of-sporothrix-schenckii-sensu-stricto-systemic-infection
#8
Juliana Aparecida Jellmayer, Lucas Souza Ferreira, Francine Alessandra Manente, Amanda Costa Gonçalves, Marisa Campos Polesi, Alexander Batista-Duharte, Iracilda Zeppone Carlos
The available information about the role of Dectin-1 in sporotrichosis is scarce. Hence, we aimed to assess Dectin-1 expression by macrophages and the activation of some related antifungal mechanisms during the Sporothrix schenckii sensu stricto infection as a first attempt to elucidate the role of this receptor in sporotrichosis. Balb/c mice were intraperitoneally infected with S. schenckii sensu stricto yeast ATCC 16345 and euthanized on days 5, 10 and 15 post-infection, when the following parameters were evaluated: fungal burden in spleen, Dectin-1 expression and nitric oxide (NO) production by peritoneal macrophages, as well as IL-1β, TNF-α and IL-10 ex vivo secretion by these same cells...
June 20, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28645522/acute-effects-of-ambient-temperature-and-particulate-air-pollution-on-fractional-exhaled-nitric-oxide-a-panel-study-among-diabetic-patients-in-shanghai-china
#9
Huichu Li, Hongjian Bai, Changyuan Yang, Renjie Chen, Cuicui Wang, Zhuohui Zhao, Haidong Kan
BACKGROUND: Epidemiological studies have shown the associations of ambient temperature and particulate matter (PM) air pollution with respiratory morbidity and mortality. However, the underlying mechanisms have not been well characterized. The aim of this study is to investigate the associations of temperature and fine and coarse PM with fractional exhaled nitric oxide (FeNO), a well-established biomarker of respiratory inflammation. METHODS: We conducted a longitudinal panel study involving six repeated FeNO tests among 33 type 2 diabetes mellitus patients from April to June 2013 in Shanghai, China...
June 20, 2017: Journal of Epidemiology
https://www.readbyqxmd.com/read/28645489/effects-of-hypnotic-bromovalerylurea-on-microglial-bv2-cells
#10
Shun Kawasaki, Naoki Abe, Fumito Ohtake, Afsana Islam, Mohammed Emamussalehin Choudhury, Ryo Utsunomiya, Satoshi Kikuchi, Tasuku Nishihara, Jun Kuwabara, Hajime Yano, Yuji Watanabe, Mayuki Aibiki, Toshihiro Yorozuya, Junya Tanaka
An old sedative and hypnotic bromovalerylurea (BU) has anti-inflammatory effects. BU suppressed nitric oxide (NO) release and proinflammatory cytokine expression by lipopolysaccharide (LPS)-treated BV2 cells, a murine microglial cell line. However, BU did not inhibit LPS-induced nuclear translocation of nuclear factor-κB and subsequent transcription. BU suppressed LPS-induced phosphorylation of signal transducer and activator of transcription 1 (STAT1) and expression of interferon regulatory factor 1 (IRF1)...
June 8, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28644965/3-4-dihydroxybenzalacetone-attenuates-lipopolysaccharide-induced-inflammation-in-acute-lung-injury-via-down-regulation-of-mmp-2-and-mmp-9-activities-through-suppressing-ros-mediated-mapk-and-pi3k-akt-signaling-pathways
#11
Wei Chao, Jeng-Shyan Deng, Shyh-Shyun Huang, Pei-Ying Li, Yu-Chia Liang, Guan-Jhong Huang
3, 4-Dihydroxybenzalacetone (DBL) is a constituent of Phellinus linteus. This study demonstrated the protective effect of DBL on lipopolysaccharide (LPS)-induced acute lung injuries in mice. Pretreatment with DBL significantly improved LPS-induced histological alterations in lung tissues. In addition, DBL markedly reduced the total cell number, the leukocytes, the protein concentrations, and decreased the release of nitrite, tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 and the activities of matrix metalloproteinase (MMP)-2 and -9 in the bronchoalveolar lavage fluid...
June 20, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28644409/quercetin-protects-obesity-induced-hypothalamic-inflammation-by-reducing-microglia-mediated-inflammatory-responses-via-ho-1-induction
#12
Jihyeon Yang, Chu-Sook Kim, Thai Hien Tu, Min-Seon Kim, Tsuyoshi Goto, Teruo Kawada, Myung-Sook Choi, Taesun Park, Mi-Kyung Sung, Jong Won Yun, Suck-Young Choe, Jee Hye Lee, Yeonsoo Joe, Hye-Seon Choi, Sung Hoon Back, Hun Taeg Chung, Rina Yu
Obesity-induced hypothalamic inflammation is characterized by activation of microglia, which are resident macrophages of the central nervous system, and is implicated in the derangement of energy homeostasis, metabolic complications, and neurodegenerative diseases. Quercetin, a naturally occurring flavonoid, is known to protect against oxidative stress and inflammation-related metabolic complications. Here, we demonstrate that quercetin reduces obesity-induced hypothalamic inflammation by inhibiting microglia-mediated inflammatory responses, and the beneficial action of quercetin is associated with heme oxygenase (HO-1) induction...
June 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28644013/a-simple-approach-to-prepare-carboxycellulose-nanofibers-from-untreated-biomass
#13
Priyanka R Sharma, Ritika Joshi, Benjamin S Hsiao
A simple approach was developed to prepare carboxycellulose nanofibers directly from untreated biomass using nitric acid or nitric acid-sodium nitrite mixtures. Experiments indicated that this approach greatly reduced the need for multi-chemicals, and offered significant benefits in lowering the consumption of water and electric energy, when compared with conventional multiple-step processes at bench scale (e.g. TEMPO oxidation). Additionally, the effluent produced by this approach could be efficaciously neutralized using base to produce nitrogen-rich salts as fertilizers...
June 23, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28643373/cytomegalovirus-dna-is-highly-prevalent-in-the-blood-of-patients-with-asthma-and-is-associated-with-age-and-asthma-traits
#14
Marek L Kowalski, Aleksandra Wardzynska, Miroslawa Studzinska, Malgorzata Pawelczyk, Zbigniew Jan Lesnikowski, Edyta Paradowska
CMV IgG antibodies have been associated with inflammageing and immunosenescence. We aimed to assess the presence of CMV DNA in the blood of adult and elderly patients with bronchial asthma to establish potential association of CMV DNAemia with asthma and asthma characteristics. Eighty-five elderly asthmatics, 74 younger asthma patients and 114 age-matched controls were recruited. The CMV DNA was detected using commercial artus assay in 10.7% of asthma patients, but was negative in all control individuals. The secondary assay identified CMV DNA in 41...
June 22, 2017: Allergy
https://www.readbyqxmd.com/read/28643085/exogenous-application-of-nitric-oxide-modulates-osmolyte-metabolism-antioxidants-enzymes-of-ascorbate-glutathione-cycle-and-promotes-growth-under-cadmium-stress-in-tomato
#15
Parvaiz Ahmad, Mohammed Abass Ahanger, Mohammed Nasser Alyemeni, Leonard Wijaya, Pravej Alam
Experiments were carried out to investigate the role of nitric oxide (NO) in ameliorating the negative effects of cadmium stress in tomato seedlings. Plants treated with cadmium (CdCl2, 150 μM) showed reduced growth, biomass yield, pigment content, chlorophyll fluorescence, and gas exchange parameters. Exogenous application of NO donor (sodium nitroprusside) with nutrient solution protected chlorophyll pigments, restored chlorophyll fluorescence and gas exchange parameters, and caused significant enhancements in growth and biomass yield...
June 22, 2017: Protoplasma
https://www.readbyqxmd.com/read/28642618/physalins-v-ix-16-24-cyclo-13-14-seco-withanolides-from-physalis-angulata-and-their-antiproliferative-and-anti-inflammatory-activities
#16
Cheng-Peng Sun, Chong-Yue Qiu, Feng Zhao, Ning Kang, Li-Xia Chen, Feng Qiu
Five new physalins, including a novel 1,10-seco one, physalin V (1), a tricarboxylic acid cycle one, physalin VIII (5), a rare 11,15-cyclo one, physalin IX (6), and two new ones, physalins VI (2) and VII (4) were isolated from stems and leaves of Physalis angulata together with eleven known analogues (3 and 7-16). Their structures were established by MS, IR, UV, and NMR spectroscopic analysis, together with the X-ray diffraction analysis of neophysalin, physalin P (12), and the structure of physalin D1 (3) has been revised here...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28641584/crotoxin-stimulates-an-m1-activation-profile-in-murine-macrophages-during-leishmania-amazonensis-infection
#17
L H S Farias, A P D Rodrigues, E C Coêlho, M F Santos, S C Sampaio, E O Silva
American tegumentary leishmaniasis is caused by different species of Leishmania. This protozoan employs several mechanisms to subvert the microbicidal activity of macrophages and, given the limited efficacy of current therapies, the development of alternative treatments is essential. Animal venoms are known to exhibit a variety of pharmacological activities, including antiparasitic effects. Crotoxin (CTX) is the main component of Crotalus durissus terrificus venom, and it has several biological effects. Nevertheless, there is no report of CTX activity during macrophage - Leishmania interactions...
June 23, 2017: Parasitology
https://www.readbyqxmd.com/read/28641545/role-of-bradykinin-in-the-regulation-of-endothelial-nitric-oxide-synthase-expression-by-cardiovascular-drugs
#18
Jin Bo Su
NO produced by eNOS plays important roles in the cardiovascular system. Alterations in eNOS activity and expression occur in various cardiovascular disorders and eNOS constitutes a therapeutic target. In addition to posttranslational modifications of eNOS that affect eNOS activity, transcriptional and post-transcriptional regulation of eNOS expression also controlls eNOS-derived NO production. Bradykinin is an important determinant of vascular function and participates in the regulation of eNOS activity and expression...
June 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28641276/atherosclerosis-and-the-hydrogen-sulfide-signaling-pathway-therapeutic-approaches-to-disease-prevention
#19
Zhi-Jun Wang, Jian Wu, Wei Guo, Yi-Zhun Zhu
Hydrogen sulfide (H2S) is now admitted as a third gasotransmitter together with nitric oxide (NO) and carbon monoxide (CO), albeit it was originally considered as a foul and poisonous gas. Endogenous H2S production in mammalian cells is counting on the three enzymes acting on cysteine. Involvement of H2S in various physiological and pathological processes has been extensively studied in the last fifteen years. Mounting evidence suggests that H2S is able to protect against atherosclerosis development and progression...
June 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28641022/a-randomized-single-dose-parallel-study-on-enhancement-of-nitric-oxide-in-serum-and-saliva-with-the-use-of-natural-sports-supplement-in-healthy-adults
#20
Joby Jacob, Sreeraj Gopi, Chandradhara Divya
Sports supplements that stimulate the production of nitric oxide (NO) are widely promoted agents in the sports nutrition domain, and nitric oxide plays an important role to enhance the cardiovascular and physical fitness of the sports participants. The purpose of the study is to investigate whether oral intake of a sports nutritional supplement (Fitnox) is able to increase nitrate (NO3(-)) and nitrite (NO2(-)) levels in blood serum and saliva of healthy adults. Fitnox is a unique blend of Kaempferia parviflora methoxy flavones, pomegranate peel polyphenols, and Moringa oleifera leaf saponins...
June 22, 2017: Journal of Dietary Supplements
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