keyword
https://read.qxmd.com/read/38536862/ultrastable-iodinated-oil-based-pickering-emulsion-enables-locoregional-sustained-codelivery-of-hypoxia-inducible-factor-1-inhibitor-and-anticancer-drugs-for-tumor-combination-chemotherapy
#1
JOURNAL ARTICLE
Zhihua Li, Xiaoya Liu, Jingyu Xiao, Hang Jiang, Le Ma, Yucheng Luo, Meijuan Wang, Yuwei Zhu, Hongliang Jiang, Hanyang Yao, To Ngai, Qiongyu Guo
Tumor hypoxia-associated drug resistance presents a major challenge for cancer chemotherapy. However, sustained delivery systems with a high loading capability of hypoxia-inducible factor-1 (HIF-1) inhibitors are still limited. Here, we developed an ultrastable iodinated oil-based Pickering emulsion (PE) to achieve locally sustained codelivery of a HIF-1 inhibitor of acriflavine and an anticancer drug of doxorubicin for tumor synergistic chemotherapy. The PE exhibited facile injectability for intratumoral administration, great radiopacity for in vivo examination, excellent physical stability (>1 mo), and long-term sustained release capability of both hydrophilic drugs (i...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38536485/green-synthesis-of-copper-nanoparticles-by-using-pineapple-peel-waste-in-vitro-characterizations-and-antibacterial-potential
#2
JOURNAL ARTICLE
Sanchita Mitra, Tarun Kumar Dua, Serina Easmin, Sucheta Sarkar, Arijit Prosad Roy, Ranabir Sahu, Gouranga Nandi, Md Salman Haydar, Swarnendu Roy, Paramita Paul
A considerable amount of fruit waste is being produced every day worldwide. The green synthesis of metal nanoparticles from fruit peel waste can be an innovative, cost-effective, and eco-friendly alternative to traditional methods. Copper nanoparticles (CuNPs) were synthesized by a green method using the pineapple peels extract (PLX) and copper sulfate pentahydrate. The formation of CuNPs was visually identified and detected by UV-Visible spectroscopy. The CuNPs were characterized by Fourier-transform infrared (FTIR) spectroscopy, particle size analyzer, scanning electron microscopy (SEM), and X-ray diffraction (XRD)...
March 27, 2024: Bioprocess and Biosystems Engineering
https://read.qxmd.com/read/38536484/kinetic-modeling-and-optimization-of-the-mono-and-diglycerides-synthesis-mediated-by-the-lipase-lipozyme%C3%A2-tl-100-l-immobilized-on-clayey-support
#3
JOURNAL ARTICLE
George F Finco, Edson A da Silva, Fernando Palú, Márcia R F Klen, Karina G Fiametti, João H C Wancura, J Vladimir Oliveira
Mono- and diglycerides play a crucial role in the food industry as multifunctional food additives and emulsifiers. Their importance stems from their unique properties, which allow them to improve the quality, texture, and stability of various food products. Here, results of the kinetic modeling of the mono- and diglycerides synthesis mediated by the lipase Lipozyme® TL 100 L immobilized on the clayey support Spectrogel® type C are reported. The support was characterized by TEM, SEM, and FTIR. Firstly, the influence of pH and lipase load on the immobilization process was analyzed, resulting in an enzymatic activity of 93...
March 27, 2024: Bioprocess and Biosystems Engineering
https://read.qxmd.com/read/38534847/application-of-machine-learning-in-the-quantitative-analysis-of-the-surface-characteristics-of-highly-abundant-cytoplasmic-proteins-toward-ai-based-biomimetics
#4
JOURNAL ARTICLE
Jooa Moon, Guanghao Hu, Tomohiro Hayashi
Proteins in the crowded environment of human cells have often been studied regarding nonspecific interactions, misfolding, and aggregation, which may cause cellular malfunction and disease. Specifically, proteins with high abundance are more susceptible to these issues due to the law of mass action. Therefore, the surfaces of highly abundant cytoplasmic (HAC) proteins directly exposed to the environment can exhibit specific physicochemical, structural, and geometrical characteristics that reduce nonspecific interactions and adapt to the environment...
March 6, 2024: Biomimetics
https://read.qxmd.com/read/38534838/recent-advances-in-scaffolds-for-guided-bone-regeneration
#5
REVIEW
Theodoros-Filippos Valamvanos, Xanthippi Dereka, Hector Katifelis, Maria Gazouli, Nefeli Lagopati
The rehabilitation of alveolar bone defects of moderate to severe size is often challenging. Currently, the therapeutic approaches used include, among others, the guided bone regeneration technique combined with various bone grafts. Although these techniques are widely applied, several limitations and complications have been reported such as morbidity, suboptimal graft/membrane resorption rate, low structural integrity, and dimensional stability. Thus, the development of biomimetic scaffolds with tailor-made characteristics that can modulate cell and tissue interaction may be a promising tool...
March 1, 2024: Biomimetics
https://read.qxmd.com/read/38534590/microscopic-and-macroscopic-characterization-of-hydrogels-based-on-poly-vinyl-alcohol-glutaraldehyde-mixtures-for-fricke-gel-dosimetry
#6
JOURNAL ARTICLE
Silvia Locarno, Paolo Arosio, Francesca Curtoni, Marco Piazzoni, Emanuele Pignoli, Salvatore Gallo
In recent decades, hydrogels have emerged as innovative soft materials with widespread applications in the medical and biomedical fields, including drug delivery, tissue engineering, and gel dosimetry. In this work, a comprehensive study of the macroscopic and microscopic properties of hydrogel matrices based on Poly(vinyl-alcohol) (PVA) chemically crosslinked with Glutaraldehyde (GTA) was reported. Five different kinds of PVAs differing in molecular weight and degree of hydrolysis were considered. The local microscopic organization of the hydrogels was studied through the use of the 1 H nuclear magnetic resonance relaxometry technique...
February 28, 2024: Gels
https://read.qxmd.com/read/38534520/knee-joint-preservation-in-tactical-athletes-a-comprehensive-approach-based-upon-lesion-location-and-restoration-of-the-osteochondral-unit
#7
REVIEW
Daniel J Cognetti, Mikalyn T Defoor, Tony T Yuan, Andrew J Sheean
The unique physical demands of tactical athletes put immense stress on the knee joint, making these individuals susceptible to injury. In order to ensure operational readiness, management options must restore and preserve the native architecture and minimize downtime, while optimizing functionality. Osteochondral lesions (OCL) of the knee have long been acknowledged as significant sources of knee pain and functional deficits. The management of OCL is predicated on certain injury characteristics, including lesion location and the extent of subchondral disease...
March 1, 2024: Bioengineering
https://read.qxmd.com/read/38534456/how-mitochondrial-signaling-games-may-shape-and-stabilize-the-nuclear-mitochondrial-symbiosis
#8
JOURNAL ARTICLE
Will Casey, Thiviya Kumaran, Steven E Massey, Bud Mishra
The eukaryotic lineage has enjoyed a long-term "stable" mutualism between nucleus and mitochondrion, since mitochondrial endosymbiosis began about 2 billion years ago. This mostly cooperative interaction has provided the basis for eukaryotic expansion and diversification, which has profoundly altered the forms of life on Earth. While we ignore the exact biochemical details of how the alpha-proteobacterial ancestor of mitochondria entered into endosymbiosis with a proto-eukaryote, in more general terms, we present a signaling games perspective of how the cooperative relationship became established, and has been maintained...
March 15, 2024: Biology
https://read.qxmd.com/read/38534228/ultrasensitive-label-free-voltammetric-detection-of-dibutyl-phthalate-based-on-poly-l-lysine-poly-3-4-ethylenedioxythiophene-porous-graphene-nanocomposite-and-molecularly-imprinted-polymers
#9
JOURNAL ARTICLE
Chuanxiang Zhang, Song Li, Lingxiao Tang, Shuo Li, Changchun Hu, Dan Zhang, Long Chao, Xueying Liu, Yimin Tan, Yan Deng
Development of an efficient technique for accurate and sensitive dibutyl phthalate (DBP) determination is crucial for food safety and environment protection. An ultrasensitive molecularly imprinted polymers (MIP) voltammetric sensor was herein engineered for the specific determination of DBP using poly-l-lysine/poly(3,4-ethylenedioxythiophene)/porous graphene nanocomposite (PLL/PEDOT-PG) and poly(o-phenylenediamine)-imprinted film as a label-free and sensing platform. Fabrication of PEDOT-PG nanocomposites was achieved through a simple liquid-liquid interfacial polymerization...
February 23, 2024: Biosensors
https://read.qxmd.com/read/38533585/the-effects-of-shoulder-stabilization-exercises-on-muscle-strength-proprioceptive-sensory-ability-and-performance-in-office-workers-with-shoulder-protraction
#10
JOURNAL ARTICLE
O Depreli, Z Erden
Objectives . Shoulder protraction is frequently seen in office workers because of working with excessive trunk flexion for a long time. This study aimed to compare the effectiveness of stabilization exercises (SE) given in addition to office exercises (OE). Methods . Sixty office workers with shoulder protraction were divided into SE + OE ( n =  30) and OE ( n =  30) groups by stratified random sampling for 8 weeks and followed up for 4 weeks. Shoulder protraction was assessed with a caliper, muscle strength with a hand-held dynamometer, proprioception with an isokinetic dynamometer, vibration sense with a vibrometer and upper extremity functional performance with the closed kinetic chain upper extremity stability test...
March 27, 2024: International Journal of Occupational Safety and Ergonomics: JOSE
https://read.qxmd.com/read/38533182/de-novo-design-of-spiro-type-hole-transporting-material-anisotropic-regulation-toward-efficient-and-stable-perovskite-solar-cells
#11
JOURNAL ARTICLE
Xuran Wang, Mingliang Wang, Zilong Zhang, Dong Wei, Shidong Cai, Yuheng Li, Rui Zhang, Liangliang Zhang, Ruidan Zhang, Chenhui Zhu, Xiaozhen Huang, Feng Gao, Peng Gao, Yang Wang, Wei Huang
2,2',7,7'-Tetrakis( N , N -di-p-methoxyphenyl)-amine-9,9'-spirobifluorene (Spiro-OMeTAD) represents the state-of-the-art hole-transporting material (HTM) in n-i-p perovskite solar cells (PSCs). However, its susceptibility to stability issues has been a long-standing concern. In this study, we embark on a comprehensive exploration of the untapped potential within the family of spiro-type HTMs using an innovative anisotropic regulation strategy. Diverging from conventional approaches that can only modify spirobifluorene with single functional group, this approach allows us to independently tailor the two orthogonal components of the spiro-skeleton at the molecular level...
2024: Research: a science partner journal
https://read.qxmd.com/read/38533102/synthesis-of-different-organic-ammonium-based-bismuth-iodide-perovskites-for-photodetection-application
#12
JOURNAL ARTICLE
Amr Elattar, Cassie Duclos, Franchesca Bellevu, Tarik Dickens, Okenwa Okoli
Bismuth-based perovskites are promising candidates for highly stable halide perovskites with low toxicity. Here, we report the synthesis of a series of bismuth iodide-based perovskites with different primary, secondary, and tertiary ammonium cations and study their structural, thermal, and optical properties, and the likelihood of photodetection. Interestingly, the variation of A-site organic ammonium cations, with different interlayer spacings between adjacent bismuth iodide monolayers, has exotic effects on the diffraction patterns and morphological structures of the perovskite crystals...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38531301/engineering-marine-phospholipid-nanoliposomes-via-glycerol-infused-proliposomes-mechanisms-strategies-and-versatile-applications-in-scalable-food-grade-nanoliposome-production
#13
JOURNAL ARTICLE
Dong-Wen Fu, Hang Xu, Rui-Qi Sun, Xue-Li Liu, Zhe Ji, Da-Yong Zhou, Liang Song
This study presents a novel approach using polyol-based proliposome to produce marine phospholipids nanoliposomes. Proliposomes were formulated by blending glycerol with phospholipids across varying mass ratios (2:1 to 1:10) at room temperature. Analysis employing polarized light microscopy, FTIR, and DSC revealed that glycerol disrupted the stacked acyl groups within phospholipids, lowering the phase transition temperature (Tm ). Krill oil phospholipids (KOP) proliposomes exhibited superior performance in nanoliposomes formation, with a mean diameter of 125...
March 15, 2024: Food Chemistry
https://read.qxmd.com/read/38530548/progress-in-polystyrene-biodegradation-by-insect-gut-microbiota
#14
REVIEW
Luhui Xu, Zelin Li, Liuwei Wang, Zihang Xu, Shulin Zhang, Qinghua Zhang
Polystyrene (PS) is frequently used in the plastics industry. However, its structural stability and difficulty to break down lead to an abundance of plastic waste in the environment, resulting in micro-nano plastics (MNPs). As MNPs are severe hazards to both human and environmental health, it is crucial to develop innovative treatment technologies to degrade plastic waste. The biodegradation of plastics by insect gut microorganisms has gained attention as it is environmentally friendly, efficient, and safe...
March 26, 2024: World Journal of Microbiology & Biotechnology
https://read.qxmd.com/read/38530534/tibiofemoral-slip-velocity-in-total-knee-arthroplasty-is-design-invariant-but-activity-dependent
#15
JOURNAL ARTICLE
Shanyuanye Guan, Raphael Dumas, Marcus G Pandy
Tibiofemoral slip velocity is a key contributor to total knee arthroplasty (TKA) component wear, yet few studies have evaluated this quantity in vivo. The aim of the present study was to measure and compare tibiofemoral slip velocities in 3 TKA designs for a range of daily activities. Mobile biplane X-ray imaging was used to measure 6-degree-of-freedom tibiofemoral kinematics and the locations of articular contact in 75 patients implanted with a posterior-stabilized, cruciate-retaining, or medial-stabilized design while each patient performed level walking, step up, step down, sit-to-stand, and stand-to-sit...
March 26, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38530495/effects-of-process-intensification-on-homogeneity-of-an-igg1-%C3%AE%C2%BA-monoclonal-antibody-during-perfusion-culture
#16
JOURNAL ARTICLE
George Liang, Chikkathur N Madhavarao, Caitlin Morris, Thomas O'Connor, Muhammad Ashraf, Seongkyu Yoon
The pharmaceutical industry employs various strategies to improve cell productivity. These strategies include process intensification, culture media improvement, clonal selection, media supplementation and genetic engineering of cells. However, improved cell productivity has inherent risk of impacting product quality attributes (PQA). PQAs may affect the products' efficacy via stability, bioavailability, or in vivo bioactivity. Variations in manufacturing process may introduce heterogeneity in the products by altering the type and extent of N-glycosylation, which is a PQA of therapeutic proteins...
March 26, 2024: Applied Microbiology and Biotechnology
https://read.qxmd.com/read/38529785/not-exclusively-the-activity-but-the-sweet-spot-a-dehydrogenase-point-mutation-synergistically-boosts-activity-substrate-tolerance-thermal-stability-and-yield
#17
JOURNAL ARTICLE
Yu-Ke Cen, Lin Zhang, Yue Jiang, Xiang-Fu Meng, Yuan Li, Chao Xiang, Ya-Ping Xue, Yu-Guo Zheng
Catalytic activity is undoubtedly a key focus in enzyme engineering. The complicated reaction conditions hinder some enzymes from industrialization even though they have relatively promising activity. This has occurred to some dehydrogenases. Hydroxysteroid dehydrogenases (HSDHs) specifically catalyze the conversion between hydroxyl and keto groups, and hold immense potential in the synthesis of steroid medicines. We underscored the importance of 7α-HSDH activity, and analyzed the overall robustness and underlying mechanisms...
March 26, 2024: Organic & Biomolecular Chemistry
https://read.qxmd.com/read/38529730/controlled-stiffness-of-direct-write-near-field-electrospun-gelatin-fibers-generates-differences-in-tenocyte-morphology-and-gene-expression
#18
JOURNAL ARTICLE
Zachary Davis, Drew Koch, Samantha Watson, Grant Scull, Ashley Brown, Lauren Schnabel, Matthew Fisher
Tendinopathy is a leading cause of mobility issues. Currently, the cell-matrix interactions involved in the development of tendinopathy are not fully understood. In vitro tendon models provide a unique tool for addressing this knowledge gap as they permit fine control over biochemical, micromechanical, and structural aspects of the local environment to explore cell-matrix interactions. In this study, direct-write, near-field electrospinning of gelatin solution was implemented to fabricate micron-scale fibrous scaffolds that mimic native collagen fiber size and orientation...
March 26, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38529724/a-histomorphometric-and-computational-investigation-of-the-stabilizing-role-of-pectinate-ligaments-in-the-aqueous-outflow-pathway
#19
JOURNAL ARTICLE
Babak Safa, Nina Sara Fraticelli Guzmán, Guorong Li, Daniel Stamer, Andrew Feola, C Ross Ethier
Murine models are commonly used to study glaucoma, the leading cause of irreversible blind-ness. Glaucoma is associated with elevated intraocular pressure (IOP), which is regulated by the tissues of the aqueous outflow pathway. In particular, pectinate ligaments (PLs) connect the iris and trabecular meshwork (TM) at the anterior chamber angle, with an unkown role in maintenance of the biomechanical stability of the aqueous outflow pathway, thus motivating this study. We conducted histomorphometric analysis and optical coherence tomography-based finite element (FE) modeling on three cohorts of C57BL/6 mice: 'young' (2-6 months), 'middle-aged' (11-16 months), and 'elderly' (25-32 months)...
March 26, 2024: Journal of Biomechanical Engineering
https://read.qxmd.com/read/38529666/suppressing-ion-migration-by-synergistic-engineering-of-anion-and-cation-towards-high-performance-inverted-perovskite-solar-cells-and-modules
#20
JOURNAL ARTICLE
Zuolin Zhang, Mengjia Li, Ru Li, Xinmeng Zhuang, Chenglin Wang, Xueni Shang, Dongmei He, Jiangzhao Chen, Cong Chen
Ion migration-induced intrinsic instability and large-area fabrication pose a tough challenge for the commercial deployment of perovskite photovoltaics. Herein, we develop an interface heterojunction and metal electrode stabilization strategy by suppressing ion migration via managing lead-based imperfections. After screening a series of cations and nonhalide anions, the ideal organic salt molecule dimethylammonium trifluoroacetate (DMATFA) consisting of dimethylammonium (DMA+ ) cation and trifluoroacetate (TFA- ) anion is selected to manipulate the surface of perovskite films...
March 26, 2024: Advanced Materials
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