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https://www.readbyqxmd.com/read/28079631/the-role-of-methicillin-resistant-staphylococcus-aureus-in-skin-and-soft-tissue-infections
#1
Matteo Bassetti, Alessia Carnelutti, Elda Righi
PURPOSE OF REVIEW: Methicillin-resistant Staphylococcus aureus (MRSA) has become a major public health issue worldwide over the last years. MRSA is frequently implicated in the development of skin and soft tissue infections, leading to significant increases in morbidity, mortality and overall healthcare costs. RECENT FINDINGS: In order to face the threat of MRSA, major changes in clinical management of skin and soft tissue infections are required. The identification of populations at risk for the acquisition of infections due to MRSA, together with the improvement of the diagnostic techniques, is paramount...
January 12, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28079630/18f-fluorodeoxyglucose-positron-emission-tomography-and-infectious-diseases-current-applications-and-future-perspectives
#2
Matteo Bassetti, Alessia Carnelutti, Daniele Muser, Elda Righi, Nicola Petrosillo, Fernando Di Gregorio, Thomas J Werner, Abass Alavi
PURPOSE OF REVIEW: 18F-Fluorodeoxyglucose positron emission tomography/computed tomography is a well-established technique for diagnosis and management of a number of neoplastic conditions. However, in recent years the body of literature regarding its potential role in infectious diseases has progressively increased, with promising results. RECENT FINDINGS: So far 18F-fluorodeoxyglucose positron emission tomography/computed tomography has a well-established role and is recommended by guidelines only in a few settings, such as prosthetic valve endocarditis, vascular device infections, and chronic osteomyelitis...
January 12, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/28070603/erratum-to-should-we-take-into-account-esbls-in-empirical-antibiotic-treatment
#3
Matteo Bassetti, Jesús Rodríguez-Baño
No abstract text is available yet for this article.
January 9, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28069978/author-response-role-of-sleep-disordered-breathing-and-sleep-wake-disturbances-for-stroke-and-stroke-recovery
#4
Dirk M Hermann, Claudio L Bassetti
No abstract text is available yet for this article.
January 10, 2017: Neurology
https://www.readbyqxmd.com/read/28061506/role-of-rem-sleep-melanin-concentrating-hormone-and-orexin-hypocretin-systems-in-the-sleep-deprivation-pre-ischemia
#5
Marta Pace, Antoine Adamantidis, Laura Facchin, Claudio Bassetti
STUDY OBJECTIVES: Sleep reduction after stroke is linked to poor recovery in patients. Conversely, a neuroprotective effect is observed in animals subjected to acute sleep deprivation (SD) before ischemia. This neuroprotection is associated with an increase of the sleep, melanin concentrating hormone (MCH) and orexin/hypocretin (OX) systems. This study aims to 1) assess the relationship between sleep and recovery; 2) test the association between MCH and OX systems with the pathological mechanisms of stroke...
2017: PloS One
https://www.readbyqxmd.com/read/28047289/tu-ab-bra-11-indications-for-online-adaptive-radiotherapy-based-on-dosimetric-consequences-of-interfractional-pancreas-to-duodenum-motion-in-mri-guided-pancreatic-radiotherapy
#6
K Mittauer, S Rosenberg, M Geurts, M Bassetti, I Chen, L Henke, J Olsen, R Kashani, A Wojcieszynski, P Harari, Z Labby, P Hill, B Paliwal, P Parikh, J Bayouth
PURPOSE: Dose limiting structures, such as the duodenum, render the treatment of pancreatic cancer challenging. In this multi-institutional study, we assess dosimetric differences caused by interfraction pancreas-to-duodenum motion using MR-IGRT to determine the potential impact of adaptive replanning. METHODS: Ten patients from two institutions undergoing MRI-guided radiotherapy with conventional fractionation (n=5) or SBRT (n=5) for pancreatic cancer were included...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047134/th-cd-202-11-implications-for-online-adaptive-and-non-adaptive-radiotherapy-of-gastic-and-gastroesophageal-junction-cancers-using-mri-guided-radiotherapy
#7
K Mittauer, M Geurts, R Toya, M Bassetti, P Harari, B Paliwal, J Bayouth
PURPOSE: Radiotherapy for gastric and gastroesophageal junction (GEJ) tumors commonly requires large margins due to deformation, motion and variable changes of the stomach anatomy, at the risk of increased normal tissue toxicities. This work quantifies the interfraction variation of stomach deformation from daily MRI-guided radiotherapy to allow for a more targeted determination of margin expansion in the treatment of gastric and GEJ tumors. METHODS: Five patients treated for gastric (n=3) and gastroesophageal junction (n=2) cancers with conventionally fractionated radiotherapy underwent daily MR imaging on a clinical MR-IGRT system...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046841/su-g-bra-01-a-real-time-tumor-localization-and-guidance-platform-for-radiotherapy-using-us-and-mri
#8
B Bednarz, W Culberson, M Bassetti, A McMillan, C Matrosic, A Shepard, J Zagzebski, S Smith, W Lee, D Mills, K Cao, B Wang, E Fiveland, R Darrow, T Foo
PURPOSE: To develop and validate a real-time motion management platform for radiotherapy that directly tracks tumor motion using ultrasound and MRI. This will be a cost-effective and non-invasive real-time platform combining the excellent temporal resolution of ultrasound with the excellent soft-tissue contrast of MRI. METHODS: A 4D planar ultrasound acquisition during the treatment that is coupled to a pre-treatment calibration training image set consisting of a simultaneous 4D ultrasound and 4D MRI acquisition...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28012683/might-real-time-pharmacokinetic-pharmacodynamic-optimisation-of-high-dose-continuous-infusion-meropenem-improve-clinical-cure-in-infections-caused-by-kpc-producing-klebsiella-pneumoniae
#9
Federico Pea, Paola Della Siega, Piergiorgio Cojutti, Assunta Sartor, Massimo Crapis, Claudio Scarparo, Matteo Bassetti
The effect of real-time pharmacokinetic/pharmacodynamic (PK/PD) optimisation of high-dose continuous-infusion meropenem on the clinical outcome of patients receiving combination antimicrobial therapy for treatment of KPC-producing Klebsiella pneumoniae (KPC-Kp) infections was retrospectively assessed. Data for all patients with KPC-Kp-related infections who received antimicrobial combination therapy containing high-dose continuous-infusion meropenem optimised by means of therapeutic drug monitoring (TDM) were retrieved...
December 8, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28007281/minimally-invasive-esophagectomy-in-a-patient-with-tetralogy-of-fallot-and-right-sided-aortic-arch
#10
Michael J Thomas, Heather L Bartlett, Michael F Bassetti, Sam J Lubner, Georgios Kirvassilis, Petros V Anagnostopoulos, James D Maloney, Ryan A Macke
Improvements in surgical technique and perioperative care have resulted in increased long-term survival for patients with congenital heart disease. As these patients begin to reach their later years, clinicians are challenged with determining optimal management of noncardiac diseases in this complex patient population, including surgically treatable malignancies. We present a case of esophageal cancer in a patient with previously repaired tetralogy of Fallot and right-sided aortic arch, treated with neoadjuvant therapy followed by laparoscopic and left thoracoscopic esophagectomy...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28003498/a-good-sleep-for-a-fresh-mind-in-patients-with-acute-traumatic-brain-injury
#11
Andrea Soddu, Claudio L Bassetti
No abstract text is available yet for this article.
December 21, 2016: Neurology
https://www.readbyqxmd.com/read/27939092/prosthetic-joints-shining-lights-on-challenging-blind-spots
#12
EDITORIAL
Kordo Saeed, Matthew Dryden, Matteo Bassetti, Eric Bonnet, Emilio Bouza, Monica Chan, Nick Cortes, Joshua S Davis, Silvano Esposito, Gérard Giordano, Ian Gould, David Hartwright, David Lye, Mercedes Marin, Rhidian Morgan-Jones, Francisco Lajara-Marco, Elda Righi, Carlo Luca Romano, John Segreti, Serhat Unal, Rhodri Llywelyn Williams, Ata Nevzat Yalcin
No abstract text is available yet for this article.
November 28, 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27902720/intervention-to-improve-appropriate-prescribing-and-reduce-polypharmacy-in-elderly-patients-admitted-to-an-internal-medicine-unit
#13
Milena Urfer, Luigia Elzi, Salome Dell-Kuster, Stefano Bassetti
BACKGROUND: Polypharmacy and inappropriate medication prescriptions are associated with increased morbidity and mortality. Most interventions proposed to improve appropriate prescribing are time and resource intensive and therefore hardly applicable in daily clinical practice. OBJECTIVE: To test the efficacy of an easy-to-use checklist aimed at supporting the therapeutic reasoning of physicians in order to reduce inappropriate prescribing and polypharmacy. METHODS: We assessed the efficacy and safety of a 5-point checklist to be used by all physicians on the internal medicine wards of a Swiss hospital by comparing outcomes in 450 consecutive patients aged ≥65 years hospitalized after the introduction of the checklist, and in 450 consecutive patients ≥65 years hospitalized before the introduction of the checklist...
2016: PloS One
https://www.readbyqxmd.com/read/27880665/the-current-treatment-landscape-candidiasis
#14
Matteo Bassetti, Maddalena Peghin, Jean-Francois Timsit
The epidemiology of Candida species infection has changed over recent decades, influenced by local hospital-related factors, patient predisposing conditions and type of antifungal agents administered. A shift from Candida albicans as the predominant pathogen towards an increasing prevalence of the species Candida glabrata and Candida parapsilosis amongst critically ill patients has been documented. Changes in Candida species distribution may impact treatment recommendations due to differences in susceptibility to antifungal agents among species...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27873018/soft-tissue-augmentation-around-osseointegrated-and-uncovered-dental-implants-a-systematic-review
#15
REVIEW
Renzo G Bassetti, Alexandra Stähli, Mario A Bassetti, Anton Sculean
OBJECTIVES: The aim was to compile the current knowledge about the efficacy of different soft tissue correction methods around osseointegrated, already uncovered and/or loaded (OU/L) implants with insufficient soft tissue conditions. Procedures to increase peri-implant keratinized mucosa (KM) width and/or soft tissue volume were considered. MATERIALS AND METHODS: Screening of two databases: MEDLINE (PubMed) and EMBASE (OVID), and manual search of articles were performed...
January 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27869098/radiation-dose-escalation-in-esophageal-cancer-revisited-a-contemporary-analysis-of-the-national-cancer-data-base-2004-to-2012
#16
Jeffrey V Brower, Shuai Chen, Michael F Bassetti, Menggang Yu, Paul M Harari, Mark A Ritter, Andrew M Baschnagel
PURPOSE: To evaluate the effect of radiation dose escalation on overall survival (OS) for patients with nonmetastatic esophageal cancer treated with concurrent radiation and chemotherapy. METHODS AND MATERIALS: Patients diagnosed with stage I to III esophageal cancer treated from 2004 to 2012 were identified from the National Cancer Data Base. Patients who received concurrent radiation and chemotherapy with radiation doses of ≥50 Gy and did not undergo surgery were included...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27844412/anti-rods-rings-autoantibody-seropositivity-does-not-affect-response-to-telaprevir-treatment-for-chronic-hepatitis-c-infection
#17
S John Calise, Nicola Bizzaro, Thuy Nguyen, Danila Bassetti, Brunetta Porcelli, Paolo Almi, Giuseppina Barberio, Giampaola Pesce, Minoru Satoh, Edward K L Chan
PURPOSE: Autoantibodies to intracellular 'rods and rings' structures (anti-rods/rings or anti-RR) are strongly associated with hepatitis C (HCV) patients treated with interferon-α/ribavirin (IFN/RBV) and are linked with non-responsiveness to IFN/RBV or relapse, especially in Italian patients. This is the first study to determine whether there is any correlation of anti-RR with non-responsiveness to IFN/RBV treatment in patients also treated with telaprevir (TPV), one of several new therapies for chronic HCV recently implemented...
December 2016: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27826061/risk-factors-and-outcomes-of-infections-by-multidrug-resistant-gram-negative-bacteria-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#18
Francesca Patriarca, Chiara Cigana, Dozzo Massimo, Davide Lazzarotto, Antonella Geromin, Miriam Isola, Marta Lisa Battista, Marta Medeot, Michela Cerno, Alessandra Sperotto, Anna Candoni, Massimo Crapis, Assunta Sartor, Claudio Scarparo, Matteo Bassetti, Renato Fanin
The objective of this study was to determine risk factors and outcomes of infections by multidrug-resistant gram-negative (MDR GN) bacteria in 241 recipients of hematopoietic stem cell transplantation (HSCT). The cumulative incidence of infections was 10.5% (95% CI, 12.0% to 25.8%), with 57% of infections occurring during the period of severe neutropenia (neutrophil count < .1 × 10(6)/L). In multivariate analysis, allogeneic transplant and colonization with MDR GN bacteria at admission to the transplant unit were significantly associated with an increased risk of infection...
February 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27823689/safety-and-efficacy-of-the-0-h-3-h-protocol-for-rapid-rule-out-of-myocardial-infarction
#19
Karin Wildi, Berit Nelles, Raphael Twerenbold, Maria Rubini Giménez, Tobias Reichlin, Hélène Singeisen, Sophie Druey, Philip Haaf, Zaid Sabti, Petra Hillinger, Cedric Jaeger, Isabel Campodarve, Philip Kreutzinger, Christian Puelacher, Zoraida Moreno Weidmann, Mathias Gugala, Gilles Pretre, Stephanie Doerflinger, Max Wagener, Fabio Stallone, Michael Freese, Claudia Stelzig, Katharina Rentsch, Stefano Bassetti, Roland Bingisser, Stefan Osswald, Christian Mueller
BACKGROUND: The early and accurate diagnosis of acute myocardial infarction (AMI) is an important medical and economic challenge. We aimed to prospectively evaluate the performance of the new European Society of Cardiology rapid 0-hour/3-hour (0 h/3 h) rule out protocol for AMI. METHODS: We enrolled 2,727 consecutive patients presenting with suspected AMI without persistent ST-segment elevation to the emergency department in a prospective international multicenter study...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27798423/sleep-wake-disturbances-in-the-premotor-and-early-stage-of-parkinson-s-disease
#20
Panagiotis Bargiotas, Michael W M Schuepbach, Claudio L Bassetti
PURPOSE OF REVIEW: Review of recent literature pertaining to frequency, associations, mechanisms, and overall significance of sleep--wake disturbances (SWD) in the premotor and early phase of Parkinson's disease. RECENT FINDINGS: SWD are frequent in Parkinson's disease and their prevalence increases with disease progression. Recent studies confirm previous findings that SWD can appear as initial manifestation of Parkinson's disease even decades before motor signs appear and highlight their clinical associations in these early stages...
December 2016: Current Opinion in Neurology
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