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https://www.readbyqxmd.com/read/29428843/challenges-in-obstructive-sleep-apnoea
#1
Walter T McNicholas, Claudio L Bassetti, Luigi Ferini-Strambi, Jean Louis Pépin, Dirk Pevernagie, Johan Verbraecken, Winfried Randerath
No abstract text is available yet for this article.
February 7, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29426692/pancreatic-gross-tumor-volume-contouring-on-computed-tomography-ct-compared-with-magnetic-resonance-imaging-mri-results-of-an-international-contouring-conference
#2
William A Hall, Hanne D Heerkens, Eric S Paulson, Gert J Meijer, Alexis N Kotte, Paul Knechtges, Parag J Parikh, Michael F Bassetti, Percy Lee, Katharine L Aitken, Manisha Palta, Sten Myrehaug, Eugene J Koay, Lorraine Portelance, Edgar Ben-Josef, Beth A Erickson
PURPOSE: Accurate identification of the gross tumor volume (GTV) in pancreatic adenocarcinoma is challenging. We sought to understand differences in GTV delineation using pancreatic computed tomography (CT) compared with magnetic resonance imaging (MRI). METHODS AND MATERIALS: Twelve attending radiation oncologists were convened for an international contouring symposium. All participants had a clinical and research interest in pancreatic adenocarcinoma. CT and MRI scans from 3 pancreatic cases were used for contouring...
November 29, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29416555/raising-concerns-about-the-sepsis-3-definitions
#3
REVIEW
Massimo Sartelli, Yoram Kluger, Luca Ansaloni, Timothy C Hardcastle, Jordi Rello, Richard R Watkins, Matteo Bassetti, Eleni Giamarellou, Federico Coccolini, Fikri M Abu-Zidan, Abdulrashid K Adesunkanmi, Goran Augustin, Gian L Baiocchi, Miklosh Bala, Oussema Baraket, Marcelo A Beltran, Asri Che Jusoh, Zaza Demetrashvili, Belinda De Simone, Hamilton P de Souza, Yunfeng Cui, R Justin Davies, Sameer Dhingra, Jose J Diaz, Salomone Di Saverio, Agron Dogjani, Mutasim M Elmangory, Mushira A Enani, Paula Ferrada, Gustavo P Fraga, Sabrina Frattima, Wagih Ghnnam, Carlos A Gomes, Souha S Kanj, Aleksandar Karamarkovic, Jakub Kenig, Faryal Khamis, Vladimir Khokha, Kaoru Koike, Kenneth Y Y Kok, Arda Isik, Francesco M Labricciosa, Rifat Latifi, Jae G Lee, Andrey Litvin, Gustavo M Machain, Ramiro Manzano-Nunez, Piotr Major, Sanjay Marwah, Michael McFarlane, Ziad A Memish, Cristian Mesina, Ernest E Moore, Frederick A Moore, Noel Naidoo, Ionut Negoi, Richard Ofori-Asenso, Iyiade Olaoye, Carlos A Ordoñez, Mouaqit Ouadii, Ciro Paolillo, Edoardo Picetti, Tadeja Pintar, Alfredo Ponce-de-Leon, Guntars Pupelis, Tarcisio Reis, Boris Sakakushev, Hossein Samadi Kafil, Norio Sato, Jay N Shah, Boonying Siribumrungwong, Peep Talving, Cristian Tranà, Jan Ulrych, Kuo-Ching Yuan, Fausto Catena
The Global Alliance for Infections in Surgery appreciates the great effort of the task force who derived and validated the Sepsis-3 definitions and considers the new definitions an important step forward in the evolution of our understanding of sepsis. Nevertheless, more than a year after their publication, we have a few concerns regarding the use of the Sepsis-3 definitions.
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29380676/the-current-role-of-glycopeptides-in-the-treatment-of-methicillin-resistant-staphylococcus-aureus-mrsa-infections-in-not-neutropenic-adults-the-viewpoint-of-a-group-of-italian-experts
#4
Ercole Concia, Claudio Viscoli, Valerio Del Bono, Maddalena Giannella, Matteo Bassetti, Giuseppe Francesco De Rosa, Emanuele Durante Mangoni, Silvano Esposito, Massimo Giusti, Paolo Grossi, Francesco Menichetti, Federico Pea, Nicola Petrosillo, Mario Tumbarello, Stefania Stefani, Mario Venditti, Pierluigi Viale
Staphylococcus aureus is still an important problem in clinical and therapeutic area, worldwide. In Italy, in recent years, methicillin resistance remained stable, yet considerably high, the percentage of strains of MRSA being around 40%. It was deemed interesting and timely to carry out a consensus conference using the RAND/UCLA method to collect the opinion of a group of experts in infectious diseases on the role of glycopeptides in the management of MRSA infections within several clinical scenarios and namely in pneumonia, bacteremia and endocarditis, joint replacement infections, skin and soft tissue infections, diabetic foot, abdominal infections and central nervous system infections...
January 30, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29379644/update-on-new-research-in-gram-negative-infections-european-congress-of-clinical-microbiology-and-infectious-diseases-2017-22-25-april-vienna-austria
#5
Matteo Bassetti, Susan Mayor
European Congress of Clinical Microbiology and Infectious Diseases 2017 (22-25 April, Vienna, Austria). Collaborative studies between hospitals in Europe and across the USA provided new insights into assessing susceptibility patterns and optimizing antimicrobial therapy in patients with infections caused by Gram-negative bacteria, including carbapenemase-producing Enterobacteriaceae (CPE) and Pseudomonas aeruginosa.
February 2018: Future Science OA
https://www.readbyqxmd.com/read/29378721/risk-factors-and-outcomes-of-endocarditis-due-to-non-hacek-gram-negative-bacilli-data-from-the-prospective-multicenter-sei-cohort
#6
Marco Falcone, Giusy Tiseo, Emanuele Durante-Mangoni, Veronica Ravasio, Francesco Barbaro, Maria Paola Ursi, Maria Bruna Pasticci, Matteo Bassetti, Paolo Grossi, Mario Venditti, Marco Rizzi
Objective: To investigate predisposing factors and outcomes of non-HACEK Gram-negative bacilli (GNB) infective endocarditis (IE) in a multicenter, contemporary cohort.Patients and Methods: Patients with IE due to GNB prospectively observed in 26 Italian centers from 2004 to 2011 were analyzed. Using a case-control design, each case was compared to three controls with IE by other etiologies matched for age and sex. Logistic regression was performed to identify risk factors for GNB IE. Factors associated with early and late mortality were assessed by Cox regression analysis...
January 29, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29351107/update-on-skin-and-soft-tissue-infections
#7
Matteo Bassetti
No abstract text is available yet for this article.
January 17, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29337703/new-antibiotics-for-ventilator-associated-pneumonia
#8
Matteo Bassetti, Antionio Vena, Nadia Castaldo, Elda Righi, Maddalena Peghin
PURPOSE OF REVIEW: Ventilator-associated pneumonia (VAP) caused by multidrug-resistant (MDR) bacteria represents a global emerging problem. Delayed prescription of an adequate treatment for VAP has been associated with higher morbidity and mortality. New molecules have been developed to face the need of compounds that are active against resistant Gram-positive and Gram-negative pathogens. The aim of this review is to summarize the current scenario of new therapeutic options for the treatment of VAP...
January 13, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29324505/when-to-switch-to-an-oral-treatment-and-or-to-discharge-a-patient-with-skin-and-soft-tissue-infections
#9
Matteo Bassetti, Christian Eckmann, Maddalena Peghin, Alessia Carnelutti, Elda Righi
PURPOSE OF REVIEW: Skin and soft tissue infections prevalence is increasing and represent a frequent cause of hospital admission. New guidelines have become available in order to better define these infections and their response to antimicrobial treatment. Gram-positive bacteria, in particular Staphylococcus aureus, remain the most frequently isolated pathogens in skin and soft tissue infections. To treat complicated forms and infections caused by drug-resistant bacteria, hospital admission and administration of intravenous antibiotics are often required, impacting on healthcare costs and patients' morbidity...
January 10, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29322386/independent-risk-factors-for-mortality-in-critically-ill-patients-with-candidemia-on-italian-internal-medicine-wards
#10
Francesco Sbrana, Emanuela Sozio, Matteo Bassetti, Andrea Ripoli, Filippo Pieralli, Anna Maria Azzini, Alessandro Morettini, Carlo Nozzoli, Maria Merelli, Sebastiano Rizzardo, Giacomo Bertolino, Davide Carrara, Claudio Scarparo, Ercole Concia, Francesco Menichetti, Carlo Tascini
Candida is an increasing cause of bloodstream infection and is associated with significant morbidity and mortality. The aim of our study is to analyze risk factors for short-term mortality in patients with bloodstream Candida spp. infections admitted to Internal Medicine Wards (IMWs). This was a retrospective case-control study between January 2012 and December 2014 from four University Hospitals in Italy, where patients with candidemia dying within 30 days from diagnosis were matched to control cases with candidemia who survived in the same period of time...
January 10, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29318460/nebulization-of-antimicrobial-agents-in-mechanically-ventilated-adults-in-2017-an-international-cross-sectional-survey
#11
Joana Alves, Emine Alp, Despoina Koulenti, Zhongheng Zhang, Stephan Ehrmann, Stijn Blot, Matteo Bassetti, Andrew Conway-Morris, Rosa Reina, Enrique Teran, Candela Sole-Lleonart, Maria Ruiz-Rodríguez, Jordi Rello
2017 ESCMID practice guidelines reported safety concerns and weak evidence of benefit supporting use of aerosolized antibiotics in mechanically ventilated patients. Our primary goal was to assess current patterns of aerosolized antibiotic prescription in mechanically ventilated patients. A sequential global survey was performed prior to the release of the ESCMID guidelines, from the 1st of February to the 30th of April 2017, using an electronic platform. Responses were analyzed comparing geographical regions...
January 9, 2018: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29304208/what-has-changed-in-the-treatment-of-invasive-candidiasis-a-look-at-the-past-10-years-and-ahead
#12
Matteo Bassetti, Elda Righi, Philippe Montravers, Oliver A Cornely
The treatment of invasive candidiasis has changed greatly in the past decade and must continue to evolve if we are to improve outcomes in this serious infection. A review of recent history may provide insights for the future. The morbidity and mortality of invasive candidiasis remain difficult to measure despite an obvious clinical burden. Current treatment guidelines now recommend echinocandins as first-line empirical treatment, with fluconazole as an acceptable alternative for selected patients, reflecting the efficacy demonstrated by echinocandins and increasing resistance observed with fluconazole...
January 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29304206/an-introduction-to-the-future-of-echinocandin-therapy
#13
Matteo Bassetti
No abstract text is available yet for this article.
January 1, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29298166/the-role-of-dalbavancin-in-skin-and-soft-tissue-infections
#14
Matteo Bassetti, Maddalena Peghin, Alessia Carnelutti, Elda Righi
PURPOSE OF REVIEW: The increase of skin and soft tissue infections (SSTIs) represents a major concern both in community and in the hospital setting. Staphylococcus aureus is the most frequently isolated pathogen, and the rise in infections due to methicillin-resistant Staphylococcus aureus (MRSA) has been associated with inadequate antibiotic treatment and increased morbidity. RECENT FINDINGS: A number of new antimicrobials with activity against drug-resistant Gram-positive pathogens, including MRSA, have been recently approved for the treatment of SSTIs...
January 2, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29288367/antimicrobial-resistance-and-antibiotic-stewardship-programs-in-the-icu-insistence-and-persistence-in-the-fight-against-resistance-a-position-statement-from-esicm-escmid-waaar-round-table-on-multi-drug-resistance
#15
Jan J De Waele, Murat Akova, Massimo Antonelli, Rafael Canton, Jean Carlet, Daniel De Backer, George Dimopoulos, José Garnacho-Montero, Jozef Kesecioglu, Jeffrey Lipman, Mervyn Mer, José-Artur Paiva, Mario Poljak, Jason A Roberts, Jesus Rodriguez Bano, Jean-François Timsit, Jean-Ralph Zahar, Matteo Bassetti
Antimicrobial resistance (AMR) is a clear and present danger to patients in any intensive care unit (ICU) around the world. Whereas AMR may affect any patient in the hospital, patients in the ICU are particularly at risk of acquiring AMR infections due to the intensity of the treatment, use of invasive devices, increased risk of transmission and exposure to antibiotics. AMR is present in every ICU, although prevalence is geographically different and AMR pathogens encountered are variable. Intensive care and infectious disease specialists from the European Society of Intensive Care Medicine, European Society of Microbiology and Infectious Diseases and World Alliance Against Antimicrobial Resistance, united in the ANTARCTICA (Antimicrobial Resistance in Critical Care) coalition, call for increased awareness and action among health care professionals to reduce AMR development in critically ill patients, to improve treatment of AMR infections and to coordinate scientific research in this high-risk patient population...
December 29, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29273978/challenges-and-solution-of-invasive-aspergillosis-in-non-neutropenic-patients-a-review
#16
REVIEW
Matteo Bassetti, Maddalena Peghin, Antonio Vena
Invasive aspergillosis (IA) is a serious opportunistic infection, which has increasingly been recognized as an emerging disease of non-neutropenic patients. In this group of patients, the diagnosis of IA can be challenging owing to the lack of specificity of symptoms, the difficulty in discriminating colonization from infection, and the lower sensitivity of microbiological and radiological tests compared with immunocompromised patients. The aim of this article is to present to clinicians a critical review on the management of IA in non-neutropenic patients...
December 22, 2017: Infectious Diseases and Therapy
https://www.readbyqxmd.com/read/29245016/preferential-myofibroblast-differentiation-of-cardiac-mesenchymal-progenitor-cells-in-the-presence-of-atrial-fibrillation
#17
Elisa Gambini, Gianluca Lorenzo Perrucci, Beatrice Bassetti, Gabriella Spaltro, Giulia Campostrini, Maria Chiara Lionetti, Alberto Pilozzi, Federico Martinelli, Andrea Faruggia, Dario DiFrancesco, Andrea Barbuti, Giulio Pompilio
Atrial fibrillation (AF) is characterized by electrical, contractile, and structural remodeling mediated by interstitial fibrosis. It has been shown that human cardiac mesenchymal progenitor cells (CMPCs) can be differentiated into endothelial, smooth muscle, and fibroblast cells. Here, we have investigated, for the first time, the contribution of CMPCs in the fibrotic process occurring in AF. As expected, right auricolae samples displayed significantly higher fibrosis in AF vs control (CTR) patients. In tissue samples of AF patients only, double staining for c-kit and the myofibroblast marker α-smooth muscle actin (α-SMA) was detected...
November 27, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29216350/italian-nationwide-survey-on-pseudomonas-aeruginosa-from-invasive-infections-activity-of-ceftolozane-tazobactam-and-comparators-and-molecular-epidemiology-of-carbapenemase-producers
#18
Tommaso Giani, Fabio Arena, Simona Pollini, Vincenzo Di Pilato, Marco Maria D'Andrea, Lucia Henrici De Angelis, Matteo Bassetti, Gian Maria Rossolini
Objectives: Pseudomonas aeruginosa is a major cause of severe healthcare-associated infections and often shows MDR phenotypes. Ceftolozane/tazobactam is a new cephalosporin/β-lactamase inhibitor combination with potent activity against P. aeruginosa. This survey was carried out to evaluate the susceptibility of P. aeruginosa, circulating in Italy, to ceftolozane/tazobactam and comparators and to investigate the molecular epidemiology of carbapenemase-producing strains. Methods: Consecutive non-replicate P...
December 5, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29197651/yawning-its-anatomy-chemistry-role-and-pathological-considerations
#19
REVIEW
Heinz Krestel, Claudio L Bassetti, Olivier Walusinski
Yawning is a clinical sign of the activity of various supra- and infratentorial brain regions including the putative brainstem motor pattern, hypothalamic paraventricular nucleus, probably the insula and limbic structures that are interconnected via a fiber network. This interaction can be seen in analogy to other cerebral functions arising from a network or zone such as language. Within this network, yawning fulfills its function in a stereotype, reflex-like manner; a phylogenetically old function, preserved across species barriers, with the purpose of arousal, communication, and maybe other functions including respiration...
November 29, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/29178247/isavuconazole-shortens-the-qtc-interval
#20
Sibylle C Mellinghoff, Matteo Bassetti, Daniela Dörfel, Stefan Hagel, Nicola Lehners, Andrzej Plis, Enrico Schalk, Antonio Vena, Oliver A Cornely
BACKGROUND: Isavuconazole is a novel antifungal drug, approved for treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner. Here, we assessed the effects of isavuconazole on the length of QTc interval. OBJECTIVES: To describe changes of the QTc interval induced by isavuconazole treatment...
November 25, 2017: Mycoses
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