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https://www.readbyqxmd.com/read/29032500/when-antibiotic-treatment-fails
#1
EDITORIAL
Matteo Bassetti, Josè Garnacho Montero, José Artur Paiva
No abstract text is available yet for this article.
October 14, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/29020126/factors-associated-with-acquisition-of-carbapenem-resistant-enterobacteriaceae
#2
Lilian Silva Lavagnoli, Bil Randerson Bassetti, Thais Dias Lemos Kaiser, Kátia Maria Kutz, Crispim Cerutti
OBJECTIVE: to identify possible risk factors for acquisition of Enterobacterial strains with a marker for resistance to carbapenems. METHODS: exploratory case-control study performed in hospital settings. The study sample consisted of patients with biological specimens that tested positive for carbapenem-resistant Enterobacteriaceae (cases), with the disk diffusion test and Etest, and controls with biological samples testing negative for carbapenem-resistant Enterobacteriaceae...
October 5, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28988525/the-role-of-biofilm-forming-on-mortality-in-patients-with-candidemia-a-study-derived-from-real-world-data
#3
Carlo Tascini, Emanuela Sozio, Laura Corte, Francesco Sbrana, Claudio Scarparo, Andrea Ripoli, Giacomo Bertolino, Maria Merelli, Enrico Tagliaferri, Antonio Corcione, Matteo Bassetti, Gianluigi Cardinali, Francesco Menichetti
BACKGROUND: Evaluation of the role on patient mortality exerted by biofilm forming (BF) Candida strains, by using predictive clinical data. METHODS: Eighty-nine strains isolated from Candida bloodstream infection, occurring in two Italian University Hospitals, were employed in this study. A random forest (RF) model was built with a procedure of iterative selection of the risk factors potentially able to predict the probability of death. The similarity between patient conditions and Bayesian clustering was calculated in order to evaluate the role of predictors in the stratification of the death risk...
October 9, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28988505/clinical-and-pharmacokinetic-drug-evaluation-of-delafloxacin-for-the-treatment-of-acute-bacterial-skin-and-skin-structure-infections
#4
Matteo Bassetti, Davide Pecori, Piergiorgio Cojutti, Federico Pea
In the era of multi-drug resistant pathogens, the adequate treatment of skin and skin structure infections remains a challenge for clinicians. Delafloxacin, with its broad spectrum against Gram-positive, Gram-negative and anaerobic organisms, represents a new therapeutic option in this setting, especially when coverage of methicillin-resistant Staphylococcus aureus is required in the empirical or targeted approach. Areas covered: In this drug evaluation, the Authors have reviewed the pharmacokinetic and pharmacodynamic characteristics of delafloxacin...
October 9, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28903607/candida-endocarditis-systematic-literature-review-from-1997-to-2014-and-analysis-of-29-cases-from-the-italian-study-of-endocarditis
#5
Simone Giuliano, Maurizio Guastalegname, Alessandro Russo, Marco Falcone, Veronica Ravasio, Marco Rizzi, Matteo Bassetti, Pierluigi Viale, Maria Bruna Pasticci, Emanuele Durante-Mangoni, Mario Venditti
Candida Endocarditis (CE) is a deadly disease. It is of paramount importance to assess risk factors for acquisition of both Candida native (NVE) and prosthetic (PVE) valve endocarditis and relate clinical features and treatment strategies with the outcome of the disease. Areas covered: We searched the literature using the Pubmed database. Cases of CE from the Italian Study on Endocarditis (SEI) were also included. Overall, 140 cases of CE were analyzed. Patients with a history of abdominal surgery and antibiotic exposure had higher probability of developing NVE than PVE...
September 14, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28900697/principles-of-antimicrobial-stewardship-for-bacterial-and-fungal-infections-in-icu
#6
EDITORIAL
Matteo Bassetti, Marin H Kollef, Garyphallia Poulakou
No abstract text is available yet for this article.
September 12, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28893689/management-of-kpc-producing-klebsiella-pneumoniae-infections
#7
REVIEW
M Bassetti, D R Giacobbe, H Giamarellou, C Viscoli, G L Daikos, G Dimopoulos, F G De Rosa, E J Giamarellos-Bourboulis, G M Rossolini, E Righi, I Karaiskos, M Tumbarello, D P Nicolau, P L Viale, G Poulakou
BACKGROUND: Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-KP) has become one of the most important contemporary pathogens, especially in endemic areas. AIMS: our aim was to provide practical suggestion for physicians dealing with the management of KPC-KP infections in critically ill patients, based on expert opinions. SOURCES: PubMed search for relevant publications related to the management of KPC-KP infections. CONTENTS: a panel of experts developed a list of 12 questions to be addressed...
September 9, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28875581/european-guideline-for-the-diagnosis-and-treatment-of-insomnia
#8
REVIEW
Dieter Riemann, Chiara Baglioni, Claudio Bassetti, Bjørn Bjorvatn, Leja Dolenc Groselj, Jason G Ellis, Colin A Espie, Diego Garcia-Borreguero, Michaela Gjerstad, Marta Gonçalves, Elisabeth Hertenstein, Markus Jansson-Fröjmark, Poul J Jennum, Damien Leger, Christoph Nissen, Liborio Parrino, Tiina Paunio, Dirk Pevernagie, Johan Verbraecken, Hans-Günter Weeß, Adam Wichniak, Irina Zavalko, Erna S Arnardottir, Oana-Claudia Deleanu, Barbara Strazisar, Marielle Zoetmulder, Kai Spiegelhalder
This European guideline for the diagnosis and treatment of insomnia was developed by a task force of the European Sleep Research Society, with the aim of providing clinical recommendations for the management of adult patients with insomnia. The guideline is based on a systematic review of relevant meta-analyses published till June 2016. The target audience for this guideline includes all clinicians involved in the management of insomnia, and the target patient population includes adults with chronic insomnia disorder...
September 5, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28859719/sleep-related-rhythmic-movement-disorder-and-obstructive-sleep-apnea-in-five-adult-patients
#9
Giacomo Chiaro, Michelangelo Maestri, Silvia Riccardi, José Haba-Rubio, Silvia Miano, Claudio L Bassetti, Raphaël C Heinzer, Mauro Manconi
Sleep-related rhythmic movements (SRRMs) are typical in infancy and childhood, where they usually occur at the wake-to-sleep transition. However, they have rarely been observed in adults, where they can be idiopathic or associated with other sleep disorders including sleep apnea. We report a case series of 5 adults with sleep-related rhythmic movement disorder, 4 of whom had a previous history of SRRMs in childhood. SRRMs mostly occurred in consolidated sleep, in association with pathological respiratory events, predominantly longer ones, especially during stage R sleep, and recovered in 1 patient with continuous positive airway pressure therapy...
August 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28854733/cell-to-cell-variability-and-robustness-in-s-phase-duration-from-genome-replication-kinetics
#10
Qing Zhang, Federico Bassetti, Marco Gherardi, Marco Cosentino Lagomarsino
Genome replication, a key process for a cell, relies on stochastic initiation by replication origins, causing a variability of replication timing from cell to cell. While stochastic models of eukaryotic replication are widely available, the link between the key parameters and overall replication timing has not been addressed systematically. We use a combined analytical and computational approach to calculate how positions and strength of many origins lead to a given cell-to-cell variability of total duration of the replication of a large region, a chromosome or the entire genome...
August 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28842283/effect-of-combination-therapy-containing-a-high-dose-carbapenem-on-mortality-in-patients-with-carbapenem-resistant-klebsiella-pneumoniae-bloodstream-infection
#11
Maddalena Giannella, Enrico Maria Trecarichi, Daniele Roberto Giacobbe, Francesco Giuseppe De, Matteo Bassetti, Alessandro Bartoloni, Michele Bartoletti, Angela Raffaella Losito, Valerio Del Bono, Silvia Corcione, Sara Tedeschi, Francesca Raffaelli, Carolina Saffioti, Teresa Spanu, Gian Maria Rossolini, Anna Marchese, Simone Ambretti, Roberto Cauda, Claudio Viscoli, Russell Edward Lewis, Pierluigi Viale, Mario Tumbarello
OBJECTIVES: To evaluate the impact of high-dose (HD) carbapenem-based combination therapy on clinical outcome in patients with monomicrobial carbapenem-resistant Klebsiella pneumoniae (CR-KP) bloodstream-infection (BSI). METHODS: Post hoc analysis of all adult patients with CR-KP BSI who were treated with combination antibiotic regimen, collected over 6-year period in 6 large teaching Italian hospitals. To control for confounding effects of HD carbapenem combination on 14-day mortality, a multivariate Cox regression analysis was performed...
August 22, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28831461/the-impact-of-brief-interventions-for-tobacco-cessation-on-patients-awareness-of-cigarette-smoking-as-a-risk-factor-for-chronic-periodontitis
#12
Mario A Bassetti, Renzo G Bassetti, Anton Sculean, Giovanni E Salvi, Michael M Bornstein, Christoph A Ramseier
PURPOSE: To evaluate the awareness of cigarette smoking as a risk factor for chronic periodontitis in patients either undergoing active periodontal treatment (APT) or enrolled in supportive periodontal therapy (SPT). MATERIALS AND METHODS: Comprehensive tobacco use history was collected with a questionnaire in 50 patients before and after APT (test) and in 50 patients (control) enrolled in SPT at the School of Dental Medicine, University of Bern. Carbon monoxide (CO) exhalation levels were measured in both APT and SPT patients...
2017: Oral Health & Preventive Dentistry
https://www.readbyqxmd.com/read/28822107/successful-treatment-and-fdg-pet-ct-monitoring-of-hhv-6-encephalitis-in-a-non-neutropenic-patient-case-report-and-literature-review
#13
Elda Righi, Alessia Carnelutti, Daniele Muser, Francesco Zaja, Elisa Lucchini, Federico Pea, Fernando Di Gregorio, Abass Alavi, Matteo Bassetti
Human herpesvirus (HHV)-6 reactivation is associated with severe forms of encephalitis among patients undergoing hematopoietic stem cell transplantation. Cases in non-neutropenic patients are uncommon. The efficacy of ganciclovir and other compounds that are used for the treatment of HHV-6 encephalitis remains suboptimal and linked to toxicity. Valganciclovir, the oral prodrug of ganciclovir, could be practical to treat outpatients, but it is not commonly used for severe cases. We report a case of HHV-6 encephalitis in a non-neutropenic patient successfully treated with valganciclovir and undergoing therapeutic drug monitoring in plasma and in the cerebrospinal fluid...
August 18, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28772275/deep-brain-stimulation-for-tremor-is-there-a-common-structure
#14
Michael Fiechter, Andreas Nowacki, Markus F Oertel, Jens Fichtner, Ines Debove, M Lenard Lachenmayer, Roland Wiest, Claudio L Bassetti, Andreas Raabe, Alain Kaelin-Lang, Michael W Schüpbach, Claudio Pollo
BACKGROUND: Subthalamic nucleus (STN) stimulation has been recognized to control resting tremor in Parkinson disease. Similarly, thalamic stimulation (ventral intermediate nucleus; VIM) has shown tremor control in Parkinson disease, essential, and intention tremors. Recently, stimulation of the posterior subthalamic area (PSA) has been associated with excellent tremor control. Thus, the optimal site of stimulation may be located in the surrounding white matter. AIMS: The objective of this work was to investigate the area of stimulation by determining the contact location correlated with the best tremor control in STN/VIM patients...
2017: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/28760900/population-pharmacokinetics-of-high-dose-continuous-infusion-meropenem-and-considerations-for-use-in-the-treatment-of-infections-due-to-kpc-producing-klebsiella-pneumoniae
#15
Piergiorgio Cojutti, Assunta Sartor, Elda Righi, Claudio Scarparo, Matteo Bassetti, Federico Pea
We assessed the population pharmacokinetics of high-dose continuous-infusion (HDCI) meropenem in a cohort of patients with Klebsiella pneumoniae carbapenemase (KPC)-producing Klebsiella pneumoniae (KPC-Kp) infections. Monte Carlo simulations were used to define the permissible HDCI meropenem regimens that could be safely considered for the treatment of KPC-Kp infections due to meropenem-resistant strains. Permissible doses were arbitrarily defined as those associated with a ≤10% to 15% likelihood of meropenem steady-state concentrations (Css) of >100 mg/liter...
October 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28733718/antimicrobial-resistance-in-the-next-30%C3%A2-years-humankind-bugs-and-drugs-a-visionary-approach
#16
REVIEW
Matteo Bassetti, Garyphallia Poulakou, Etienne Ruppe, Emilio Bouza, Sebastian J Van Hal, Adrian Brink
PURPOSE: To describe the current standards of care and major recent advances with regard to antimicrobial resistance (AMR) and to give a prospective overview for the next 30 years in this field. METHODS: Review of medical literature and expert opinion were used in the development of this review. RESULTS: There is undoubtedly a large clinical and public health burden associated with AMR in ICU, but it is challenging to quantify the associated excess morbidity and mortality...
July 21, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28720127/parasomnia-overlap-disorder-parkinson-s-disease-and-subthalamic-deep-brain-stimulation-three-case-reports
#17
Panagiotis Bargiotas, Julia Muellner, W M Michael Schuepbach, Claudio L Bassetti
BACKGROUND: Parasomnia overlap disorder (POD) is a distinct parasomnia and characterized by concomitant manifestation of rapid-eye-movement (REM)- and non-REM (NREM)-parasomnias. Although not uncommon among patients with Parkinson's disease, POD is often under-investigated. CASE PRESENTATION: This is the first report of patients with PD and features of POD that underwent deep brain stimulation. Our patients exhibited different outcomes of POD features after subthalamic deep brain stimulation...
July 18, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28666965/individualizing-duration-of-antibiotic-therapy-in-community-acquired-pneumonia
#18
Stefano Aliberti, Julio Ramirez, Fabio Giuliani, Timothy Wiemken, Giovanni Sotgiu, Sara Tedeschi, Manuela Carugati, Vincenzo Valenti, Marco Marchioni, Marco Camera, Roberto Piro, Manuela Del Forno, Giuseppe Milani, Paola Faverio, Luca Richeldi, Martina Deotto, Massimiliano Villani, Antonio Voza, Eleonora Tobaldini, Mauro Bernardi, Andrea Bellone, Matteo Bassetti, Francesco Blasi
International experts suggest tailoring antibiotic duration in community-acquired pneumonia (CAP) according to patients' characteristics. We aimed to assess the effectiveness of an individualized approach to antibiotic duration based on time in which CAP patients reach clinical stability during hospitalization. In a multicenter, non-inferiority, randomized, controlled trial hospitalized adult patients with CAP reaching clinical stability within 5 days after hospitalization were randomized to a standard vs. individualized antibiotic duration...
August 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28652216/fungemia-and-necrotic-lymph-node-infection-with-sporopachydermia-cereana-in-a-patient-with-acute-myeloid-leukemia
#19
Craig Kingston, Michael Medinger, Florian Banderet-Uglioni, Stefano Bassetti, Mario Bargetzi, Sebastian Haubitz, Christoph A Fux, Veronika Bättig, Daniel Goldenberger, Jakob Passweg, Marc Heizmann
Sporopachydermia cereana is a rare yeast found in necrotic cactus tissue, predominantly in the Americas. Infection in humans with clinical data has only been reported in four patients so far, all of whom died, either directly from the pathogen or from other complications of immunosuppression. Treatment of the yeast is complicated by difficulties in identification of the pathogen with conventional diagnostic techniques and by intrinsic resistance to echinocandins. The first patient to survive a disseminated infection with S...
June 23, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28634967/sleep-disordered-breathing-clinical-features-pathophysiology-and-diagnosis
#20
Sebastian Robert Ott, Lyudmila Korostovtseva, Markus Schmidt, Thomas Horvath, Anne-Kathrin Brill, Claudio L Bassetti
In recent decades, the association between sleep-disordered breathing (SDB) and cardio- and cerebrovascular diseases (including hypertension, coronary heart disease and stroke) has been the focus of interest of both clinicians and researchers. A growing concern is the increasing prevalence of SDB in the general population, which can be partly explained by the rise in obesity prevalence and population aging, as well as by the development of enhanced diagnostic tools and approaches. Because of evidence of adverse long-term effects of SDB on cardiovascular morbidity and overall mortality, systematic screening for SDB should be considered for populations at risk...
June 21, 2017: Swiss Medical Weekly
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