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https://www.readbyqxmd.com/read/27902720/intervention-to-improve-appropriate-prescribing-and-reduce-polypharmacy-in-elderly-patients-admitted-to-an-internal-medicine-unit
#1
Milena Urfer, Luigia Elzi, Salome Dell-Kuster, Stefano Bassetti
BACKGROUND: Polypharmacy and inappropriate medication prescriptions are associated with increased morbidity and mortality. Most interventions proposed to improve appropriate prescribing are time and resource intensive and therefore hardly applicable in daily clinical practice. OBJECTIVE: To test the efficacy of an easy-to-use checklist aimed at supporting the therapeutic reasoning of physicians in order to reduce inappropriate prescribing and polypharmacy. METHODS: We assessed the efficacy and safety of a 5-point checklist to be used by all physicians on the internal medicine wards of a Swiss hospital by comparing outcomes in 450 consecutive patients aged ≥65 years hospitalized after the introduction of the checklist, and in 450 consecutive patients ≥65 years hospitalized before the introduction of the checklist...
2016: PloS One
https://www.readbyqxmd.com/read/27880665/the-current-treatment-landscape-candidiasis
#2
Matteo Bassetti, Maddalena Peghin, Jean-Francois Timsit
The epidemiology of Candida species infection has changed over recent decades, influenced by local hospital-related factors, patient predisposing conditions and type of antifungal agents administered. A shift from Candida albicans as the predominant pathogen towards an increasing prevalence of the species Candida glabrata and Candida parapsilosis amongst critically ill patients has been documented. Changes in Candida species distribution may impact treatment recommendations due to differences in susceptibility to antifungal agents among species...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27873018/soft-tissue-augmentation-around-osseointegrated-and-uncovered-dental-implants-a-systematic-review
#3
REVIEW
Renzo G Bassetti, Alexandra Stähli, Mario A Bassetti, Anton Sculean
OBJECTIVES: The aim was to compile the current knowledge about the efficacy of different soft tissue correction methods around osseointegrated, already uncovered and/or loaded (OU/L) implants with insufficient soft tissue conditions. Procedures to increase peri-implant keratinized mucosa (KM) width and/or soft tissue volume were considered. MATERIALS AND METHODS: Screening of two databases: MEDLINE (PubMed) and EMBASE (OVID), and manual search of articles were performed...
November 21, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27869098/radiation-dose-escalation-in-esophageal-cancer-revisited-a-contemporary-analysis-of-the-national-cancer-data-base-2004-to-2012
#4
Jeffrey V Brower, Shuai Chen, Michael F Bassetti, Menggang Yu, Paul M Harari, Mark A Ritter, Andrew M Baschnagel
PURPOSE: To evaluate the effect of radiation dose escalation on overall survival (OS) for patients with nonmetastatic esophageal cancer treated with concurrent radiation and chemotherapy. METHODS AND MATERIALS: Patients diagnosed with stage I to III esophageal cancer treated from 2004 to 2012 were identified from the National Cancer Data Base. Patients who received concurrent radiation and chemotherapy with radiation doses of ≥50 Gy and did not undergo surgery were included...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27844412/anti-rods-rings-autoantibody-seropositivity-does-not-affect-response-to-telaprevir-treatment-for-chronic-hepatitis-c-infection
#5
S John Calise, Nicola Bizzaro, Thuy Nguyen, Danila Bassetti, Brunetta Porcelli, Paolo Almi, Giuseppina Barberio, Giampaola Pesce, Minoru Satoh, Edward K L Chan
PURPOSE: Autoantibodies to intracellular 'rods and rings' structures (anti-rods/rings or anti-RR) are strongly associated with hepatitis C (HCV) patients treated with interferon-α/ribavirin (IFN/RBV) and are linked with non-responsiveness to IFN/RBV or relapse, especially in Italian patients. This is the first study to determine whether there is any correlation of anti-RR with non-responsiveness to IFN/RBV treatment in patients also treated with telaprevir (TPV), one of several new therapies for chronic HCV recently implemented...
December 2016: Auto- Immunity Highlights
https://www.readbyqxmd.com/read/27826061/risk-factors-and-outcome-of-infections-by-multidrug-resistant-gram-negative-bacteria-in-patients-undergoing-hematopoietic-stem-cell-transplantation
#6
F Patriarca, C Cigana, D Massimo, D Lazzarotto, A Geromin, M Isola, M L Battista, M Medeot, M Cerno, A Sperotto, A Candoni, M Crapis, A Sartor, C Scarparo, M Bassetti, R Fanin
Objective of this study was to determine risk factors and outcome of infections by multidrug-resistant Gram-negative (MDR GN) bacteria in 241 recipients of hematopoietic stem cell transplantation (HSCT). The cumulative incidence of infections was 10.5% (95% CI,12.0%-25.8%), with 57% of infections occurring during the period of severe neutropenia (neutrophil count < 0.1 x 10(6)/L). In multivariate analysis, allogeneic transplant and colonization with MDR GN bacteria at admission to the Transplant Unit were significantly associated with an increased risk of infection...
November 4, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27823689/safety-and-efficacy-of-the-0-h-3-h-protocol-for-rapid-rule-out-of-myocardial-infarction
#7
Karin Wildi, Berit Nelles, Raphael Twerenbold, Maria Rubini Giménez, Tobias Reichlin, Hélène Singeisen, Sophie Druey, Philip Haaf, Zaid Sabti, Petra Hillinger, Cedric Jaeger, Isabel Campodarve, Philip Kreutzinger, Christian Puelacher, Zoraida Moreno Weidmann, Mathias Gugala, Gilles Pretre, Stephanie Doerflinger, Max Wagener, Fabio Stallone, Michael Freese, Claudia Stelzig, Katharina Rentsch, Stefano Bassetti, Roland Bingisser, Stefan Osswald, Christian Mueller
BACKGROUND: The early and accurate diagnosis of acute myocardial infarction (AMI) is an important medical and economic challenge. We aimed to prospectively evaluate the performance of the new European Society of Cardiology rapid 0-hour/3-hour (0 h/3 h) rule out protocol for AMI. METHODS: We enrolled 2,727 consecutive patients presenting with suspected AMI without persistent ST-segment elevation to the emergency department in a prospective international multicenter study...
November 2016: American Heart Journal
https://www.readbyqxmd.com/read/27798423/sleep-wake-disturbances-in-the-premotor-and-early-stage-of-parkinson-s-disease
#8
Panagiotis Bargiotas, Michael W M Schuepbach, Claudio L Bassetti
PURPOSE OF REVIEW: Review of recent literature pertaining to frequency, associations, mechanisms, and overall significance of sleep--wake disturbances (SWD) in the premotor and early phase of Parkinson's disease. RECENT FINDINGS: SWD are frequent in Parkinson's disease and their prevalence increases with disease progression. Recent studies confirm previous findings that SWD can appear as initial manifestation of Parkinson's disease even decades before motor signs appear and highlight their clinical associations in these early stages...
December 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27770171/should-we-take-into-account-esbls-in-empirical-antibiotic-treatment
#9
Bassetti Matteo, Jesús Rodríguez Baño
No abstract text is available yet for this article.
October 21, 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/27766913/patient-specific-risk-stratification-for-antimicrobial-resistance-and-possible-treatment-strategies-in-gram-negative-bacterial-infections
#10
Matteo Bassetti, Alessia Carnelutti, Maddalena Peghin
The isolation of multi-drug-resistant gram-negative (MDRGN) pathogens has progressively increased worldwide and has been associated with important delays in the prescription of an adequate antibiotic treatment, resulting in increased mortality rates. Patient's stratification for MDRGN infections to optimize the prescription of an adequate empiric antimicrobial regimen is crucial. Areas covered: This article covers MDRGN epidemiology, with a specific focus on risk factors for harbouring infections sustained by extended-spectrum-Beta-lactamase (ESBL), carbapenem resistant Enterobacteriacae (CRE), MDR Pseudomonas aeruginosa and MDR Acinetobacter baumanii...
November 7, 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27737943/power-is-nothing-without-control-the-enduring-search-for-the-best-cell-in-cardiac-cell-therapy-at-a-crossroads
#11
Beatrice Bassetti, Maurizio C Capogrossi, Giulio Pompilio
No abstract text is available yet for this article.
October 14, 2016: Circulation Research
https://www.readbyqxmd.com/read/27675974/real-time-magnetic-resonance-imaging-guided-radiation-therapy-for-gastroesophageal-junction-gastric-cancers
#12
S A Rosenberg, A P Wojcieszynski, C R Hullett, M W Geurts, J Bayouth, P M Harari, M Bassetti
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675808/multi-institutional-investigation-of-relative-pancreatic-tumor-to-duodenal-motion-in-magnetic-resonance-imaging-guided-radiation-therapy-for-potential-online-adaptive-radiation-therapy
#13
K E Mittauer, S A Rosenberg, M W Geurts, I Chen, L E Henke, J R Olsen, R Kashani, A P Wojcieszynski, P M Harari, J Bayouth, Z E Labby, P M Hill, B R Paliwal, P J Parikh, M Bassetti
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675769/dose-escalated-radiation-therapy-is-associated-with-improved-survival-in-patients-with-stage-iii-non-small-cell-lung-cancer-analysis-of-the-national-cancer-data-base
#14
J V Brower, A Amini, C R Hullett, A P Wojcieszynski, M Bassetti, M E Witek, S Chen, M Yu, A M Baschnagel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675740/overall-survival-benefit-of-intensity-modulated-compared-with-3d-conformal-radiation-therapy-in-the-definitive-management-of-esophageal-cancer-analysis-of-the-national-cancer-data-base-ncdb
#15
J V Brower, S Zhang, M A Ritter, M Bassetti, R Chappell, A M Baschnagel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674603/rt-answers-will-it-provide-the-right-answer-for-patient-information
#16
S A Rosenberg, D M Francis, C R Hullett, M Fisher, J Schuster, M Bassetti, R J Kimple
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673945/treatment-patterns-and-outcomes-among-elderly-patients-with-locally-advanced-esophageal-cancer-a-national-cancer-data-base-analysis
#17
C R Hullett, J V Brower, S A Rosenberg, A P Wojcieszynski, M Bassetti, M A Ritter, R Macke, J Maloney, P M Harari, A M Baschnagel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673894/quantification-of-interfractional-gastrointestinal-tract-motion-for-pancreatic-cancer-radiation-therapy
#18
I Chen, K E Mittauer, L E Henke, S Acharya, Y Lu, C C Chen, S A Rosenberg, M W Geurts, A P Wojcieszynski, P J Parikh, M Bassetti, R Kashani
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27663932/online-patient-information-from-radiation-oncology-departments-is-too-complex-for-the-general-population
#19
Stephen A Rosenberg, David M Francis, Craig R Hullet, Zachary S Morris, Jeffrey V Brower, Bethany M Anderson, Kristin A Bradley, Michael F Bassetti, Randall J Kimple
PURPOSE: Nearly two-thirds of cancer patients seek information about their diagnosis online. We assessed the readability of online patient education materials found on academic radiation oncology department Web sites to determine whether they adhered to guidelines suggesting that information be presented at a sixth-grade reading level. METHODS AND MATERIALS: The Association of American Medical Colleges Web site was used to identify all academic radiation oncology departments in the United States...
August 1, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/27652151/low-sensitivity-of-needle-aspiration-cultures-in-patients-with-cellulitis-erysipelas
#20
Rein Jan Piso, R Pop, M Wieland, I Griesshammer, M Urfer, U Schibli, S Bassetti
PURPOSE: Cellulitis is normally treated without knowledge of the responsible pathogen. Blood cultures are positive in about 2-4 %, and superficial swabs are of no value. Needle aspiration has been proposed with identifying the likely pathogen in up to 29 %, but these studies are of older date and the technique is not widely used. METHODS: We prospectively evaluated the sensitivity of needle aspiration cultures in all patients with erysipelas/cellulitis. Diagnosis was made clinically by the treating physician...
2016: SpringerPlus
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