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https://www.readbyqxmd.com/read/28906003/inclusion-of-mers-spike-protein-elisa-in-algorithm-to-determine-serologic-evidence-of-mers-cov-infection
#1
Suvang Trivedi, Congrong Miao, Mohammad Mousa Al-Abdallat, Aktham Haddadin, Sultan Alqasrawi, Ibrahim Iblan, Mohannad Al Nsour, Tarek Alsanouri, Sami Sheikh Ali, Brian Rha, Susan I Gerber, Daniel C Payne, Azaibi Tamin, Natalie J Thornburg
The Centers for Disease Control and Prevention (CDC) algorithm for detecting presence of serum antibodies against Middle East Respiratory Syndrome coronavirus (MERS-CoV) in subjects with potential infections with the virus has included screening by indirect ELISA against recombinant nucleocapsid (N) protein and confirmation by immunofluorescent staining of infected monolayers and/or microneutralization titration. Other international groups include indirect ELISA assays using the spike (S) protein, as part of their serological determinations...
September 14, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28902913/identification-of-diverse-viruses-in-upper-respiratory-samples-in-dromedary-camels-from-united-arab-emirates
#2
Yan Li, Abdelmalik Ibrahim Khalafalla, Clinton R Paden, Mohammed F Yusof, Yassir M Eltahir, Zulaikha M Al Hammadi, Ying Tao, Krista Queen, Farida Al Hosani, Susan I Gerber, Aron J Hall, Salama Al Muhairi, Suxiang Tong
Camels are known carriers for many viral pathogens, including Middle East respiratory syndrome coronavirus (MERS-CoV). It is likely that there are additional, as yet unidentified viruses in camels with the potential to cause disease in humans. In this study, we performed metagenomic sequencing analysis on nasopharyngeal swab samples from 108 MERS-CoV-positive dromedary camels from a live animal market in Abu Dhabi, United Arab Emirates. We obtained a total of 846.72 million high-quality reads from these nasopharyngeal swab samples, of which 2...
2017: PloS One
https://www.readbyqxmd.com/read/28885377/clinical-pearls-in-venovenous-extracorporeal-life-support-for-adult-respiratory-failure
#3
Chee Kiang Tay, Kiick Sung, Yang Hyun Cho
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e...
September 6, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28875620/mers-cov-infection-in-a-pregnant-woman-in-korea
#4
Soo Young Jeong, Se In Sung, Ji Hee Sung, So Yoon Ahn, Eun Suk Kang, Yun Sil Chang, Won Soon Park, Jong Hwa Kim
Middle East respiratory syndrome (MERS) is a lethal respiratory disease - caused by MERS-coronavirus (MERS-CoV) which was first identified in 2012. Especially, pregnant women can be expected as highly vulnerable candidates for this viral infection. In May 2015, this virus was spread in Korea and a pregnant woman was confirmed with positive result of MERS-CoV polymerase chain reaction (PCR). Her condition was improved only with conservative treatment. After a full recovery of MERS, the patient manifested abrupt vaginal bleeding with rupture of membrane...
October 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28864360/current-treatment-options-and-the-role-of-peptides-as-potential-therapeutic-components-for-middle-east-respiratory-syndrome-mers-a-review
#5
REVIEW
Sabeena Mustafa, Hanan Balkhy, Musa Nur Gabere
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a highly pathogenic respiratory virus with mechanisms that may be driven by innate immune responses. Despite the effort of scientific studies related to this virus, Middle East Respiratory Syndrome (MERS) is still a public health concern. MERS-CoV infection has a high mortality rate, and to date, no therapeutic or vaccine has been discovered, that is effective in treating or preventing the disease. In this review, we summarize our understanding of the molecular and biological events of compounds acting as MERS-CoV inhibitors, the outcomes of existing therapeutic options and the various drugs undergoing clinical trials...
August 29, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28855003/a-review-of-candidate-therapies-for-middle-east-respiratory-syndrome-from-a-molecular-perspective
#6
Ali A Rabaan, Shamsah H Alahmed, Ali M Bazzi, Hatem M Alhani
There have been 2040 laboratory-confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) in 27 countries, with a mortality rate of 34.9 %. There is no specific therapy. The current therapies have mainly been adapted from severe acute respiratory syndrome (SARS-CoV) treatments, including broad-spectrum antibiotics, corticosteroids, interferons, ribavirin, lopinavir-ritonavir or mycophenolate mofetil, and have not been subject to well-organized clinical trials. The development of specific therapies and vaccines is therefore urgently required...
August 31, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28846484/vaccines-for-emerging-infectious-diseases-lessons-from-mers-coronavirus-and-zika-virus
#7
Joel N Maslow
The past decade and a half has been characterized by numerous emerging infectious diseases. With each new threat, there has been a call for rapid vaccine development. Pathogens such as the Middle East Respiratory Syndrome coronavirus (MERS-CoV) and the Zika virus represent either new viral entities or viruses emergent in new geographic locales and characterized bywith novel complications. Both serve as paradigms for the global spread that can accompany new pathogens. In this paper, we review the epidemiology and pathogenesis of MERS-CoV and Zika virus with respect to vaccine development...
August 28, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28840986/performance-evaluation-of-the-powerchek-mers-upe-orf1a-real-time-pcr-kit-for-the-detection-of-middle-east-respiratory-syndrome-coronavirus-rna
#8
Hee Jae Huh, Ji Youn Kim, Hyeon Jeong Kwon, Sun Ae Yun, Myoung Keun Lee, Chang Seok Ki, Nam Yong Lee, Jong Won Kim
BACKGROUND: Molecular detection of Middle East respiratory syndrome coronavirus (MERS-CoV) using real-time reverse transcription (rRT)-PCR assays is the method of choice for diagnosis of MERS. We evaluated the performance of the PowerChek MERS (upE & ORF1a) real-time PCR Kit (PowerChek MERS assay; Kogene Biotech, Korea) a one-step rRT-PCR assay for the qualitative detection of MERS-CoV. METHODS: We evaluated PowerChek MERS assay performance in comparison with nested RT-PCR and sequencing of the RNA-dependent RNA polymerase (RdRp) and N genes...
November 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28830941/mers-cov-accessory-orfs-play-key-role-for-infection-and-pathogenesis
#9
Vineet D Menachery, Hugh D Mitchell, Adam S Cockrell, Lisa E Gralinski, Boyd L Yount, Rachel L Graham, Eileen T McAnarney, Madeline G Douglas, Trevor Scobey, Anne Beall, Kenneth Dinnon, Jacob F Kocher, Andrew E Hale, Kelly G Stratton, Katrina M Waters, Ralph S Baric
While dispensable for viral replication, coronavirus (CoV) accessory open reading frame (ORF) proteins often play critical roles during infection and pathogenesis. Utilizing a previously generated mutant, we demonstrate that the absence of all four Middle East respiratory syndrome CoV (MERS-CoV) accessory ORFs (deletion of ORF3, -4a, -4b, and -5 [dORF3-5]) has major implications for viral replication and pathogenesis. Importantly, attenuation of the dORF3-5 mutant is primarily driven by dysregulated host responses, including disrupted cell processes, augmented interferon (IFN) pathway activation, and robust inflammation...
August 22, 2017: MBio
https://www.readbyqxmd.com/read/28813689/large-scale-machine-learning-of-media-outlets-for-understanding-public-reactions-to-nation-wide-viral-infection-outbreaks
#10
Sungwoon Choi, Jangho Lee, Min-Gyu Kang, Hyeyoung Min, Yoon-Seok Chang, Sungroh Yoon
From May to July 2015, there was a nation-wide outbreak of Middle East respiratory syndrome (MERS) in Korea. MERS is caused by MERS-CoV, an enveloped, positive-sense, single stranded RNA virus belonging to the family Coronaviridae. Despite expert opinions that the danger of MERS might be exaggerated, there was an overreaction by the public according to the Korean mass media, which led to a noticeable reduction in social and economic activities during the outbreak. To explain this phenomenon, we presumed that machine learning-based analysis of media outlets would be helpful and collected a number of Korean mass media articles and short-text comments produced during the 10-week outbreak...
August 13, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28808497/prevalence-of-antibodies-against-the-middle-east-respiratory-syndrome-coronavirus-influenza-a-and-b-viruses-among-blood-donors-saudi-arabia
#11
Manar Alrashid, Alanoud Abu Taleb, Ali Hajeer, Yaseen Arabi
No abstract text is available yet for this article.
July 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/28807812/evaluation-and-clinical-validation-of-two-field-deployable-reverse-transcription-insulated-isothermal-pcr-assays-for-the-detection-of-the-middle-east-respiratory-syndrome-coronavirus
#12
Yun Young Go, Yeon-Sook Kim, Shinhye Cheon, Sangwoo Nam, Keun Bon Ku, Meehyein Kim, Nam Hyuk Cho, Hyun Park, Pei-Yu Alison Lee, Yu-Chun Lin, Yun-Long Tsai, Hwa-Tang Thomas Wang, Udeni B R Balasuriya
Middle East respiratory syndrome (MERS) is an emerging zoonotic viral respiratory disease that was first identified in Saudi Arabia in 2012. In 2015, the largest MERS outbreak outside of the Middle East region occurred in the Republic of Korea. The rapid nosocomial transmission of MERS-coronavirus (MERS-CoV) in Korean healthcare settings highlighted the importance and urgent need for a rapid and reliable on-site diagnostic assay to implement effective control and preventive measures. Here, we describe the evaluation and validation of two newly developed reverse transcription-insulated isothermal PCR (RT-iiPCR) methods targeting the ORF1a and upE genes of MERS-CoV...
August 11, 2017: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/28805465/what-we-are-watching-top-global-infectious-disease-threats-2013-2016-an-update-from-cdc-s-global-disease-detection-operations-center
#13
Kira A Christian, A Danielle Iuliano, Timothy M Uyeki, Eric D Mintz, Stuart T Nichol, Pierre Rollin, J Erin Staples, Ray R Arthur
To better track public health events in areas where the public health system is unable or unwilling to report the event to appropriate public health authorities, agencies can conduct event-based surveillance, which is defined as the organized collection, monitoring, assessment, and interpretation of unstructured information regarding public health events that may represent an acute risk to public health. The US Centers for Disease Control and Prevention's (CDC's) Global Disease Detection Operations Center (GDDOC) was created in 2007 to serve as CDC's platform dedicated to conducting worldwide event-based surveillance, which is now highlighted as part of the "detect" element of the Global Health Security Agenda (GHSA)...
August 14, 2017: Health Security
https://www.readbyqxmd.com/read/28794876/the-history-and-epidemiology-of-middle-east-respiratory-syndrome-corona-virus
#14
REVIEW
Aisha M Al-Osail, Marwan J Al-Wazzah
Corona viruses cause common cold, and infections caused by corona viruses are generally self-resolving. During the last 4 years, corona viruses have become the most important viruses worldwide because of the occurrence of several recent deaths caused by corona viruses in Saudi Arabia. Spread of the infection occurred worldwide; however, most cases of mortality have occurred in the Middle East. Owing to the predominance of outbreaks in the Middle Eastern countries, the virus was renamed a Middle East respiratory syndrome corona virus (MERS-CoV) by the Corona virus Study Group...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/28774161/suggestions-on-improvement-of-infectious-disease-law-and-regulations
#15
Mijeong Park
Purpose: The study's perspective is through examining an enactment for the New amendment for legislation, to make proposals for a more rational and concrete basis in the interpretation and application of the Korean legal regime in global infectious disease emergency situations. Methods: The Republic of Korea reported its first laboratory-confirmed case of Middle East Respiratory Syndrome Corona Virus (MERS-CoV) on 20 May 2015. Since the first index case, Korean public health authorities enforced many public health measures that were not authorized in the law...
July 25, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/28769010/comparative-genomic-analysis-mers-cov-isolated-from-humans-and-camels-with-special-reference-to-virus-encoded-helicase
#16
Mohamed Alnazawi, Abdallah Altaher, Mahmoud Kandeel
Middle East Respiratory Syndrome Coronavirus (MERS CoV) is a new emerging viral disease characterized by high fatality rate. Understanding MERS CoV genetic aspects and codon usage pattern is important to understand MERS CoV survival, adaptation, evolution, resistance to innate immunity, and help in finding the unique aspects of the virus for future drug discovery experiments. In this work, we provide comprehensive analysis of 238 MERS CoV full genomes comprised of human (hMERS) and camel (cMERS) isolates of the virus...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28747502/permissivity-of-dpp4-orthologs-to-mers-coronavirus-is-governed-by-glycosylation-and-other-complex-determinants
#17
Kayla M Peck, Trevor Scobey, Jesica Swanstrom, Kara L Jensen, Christina L Burch, Ralph S Baric, Mark T Heise
Middle East respiratory syndrome coronavirus (MERS-CoV) utilizes dipeptidyl peptidase 4 (DPP4) as an entry receptor. While bat, camel, and human DPP4 support MERS-CoV infection, several DPP4 orthologs, including mouse, ferret, hamster, and guinea pig, do not. Previous work revealed that glycosylation of mouse DPP4 plays a role in blocking MERS-CoV infection. Here, we test whether glycosylation also acts as a determinant of permissivity for ferret, hamster, and guinea pig DPP4. We find that while glycosylation plays an important role in these orthologs, additional sequence and structural determinants impact their ability to act as functional receptors for MERS-CoV...
July 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28722623/the-use-of-xenosurveillance-to-detect-human-bacteria-parasites-and-viruses-in-mosquito-bloodmeals
#18
Joseph R Fauver, Alex Gendernalik, James Weger-Lucarelli, Nathan D Grubaugh, Doug E Brackney, Brian D Foy, Gregory D Ebel
Infectious disease surveillance is hindered by several factors, including limited infrastructure and geographic isolation of many resource-poor regions. In addition, the complexities of sample acquisition, processing, and analysis, even in developed regions, can be rate limiting. Therefore, new strategies to survey human populations for emerging pathogens are necessary. Xenosurveillance is a method that utilizes mosquitoes as sampling devices to search for genetic signatures of pathogens in vertebrates. Previously we demonstrated that xenosurveillance can detect viral RNA in both laboratory and field settings...
August 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28719257/no-serologic-evidence-of-middle-east-respiratory-syndrome-coronavirus-infection-among-camel-farmers-exposed-to-highly-seropositive-camel-herds-a-household-linked-study-kenya-2013
#19
Peninah Munyua, Victor Max Corman, Austine Bitek, Eric Osoro, Benjamin Meyer, Marcel A Müller, Erik Lattwein, S M Thumbi, Rees Murithi, Marc-Alain Widdowson, Christian Drosten, M Kariuki Njenga
AbstractHigh seroprevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) among camels has been reported in Kenya and other countries in Africa. To date, the only report of MERS-CoV seropositivity among humans in Kenya is of two livestock keepers with no known contact with camels. We assessed whether persons exposed to seropositive camels at household level had serological evidence of infection. In 2013, 760 human and 879 camel sera were collected from 275 and 85 households respectively in Marsabit County...
June 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28712204/middle-east-respiratory-syndrome-corona-virus-alert-verification-in-mirpur-azad-kashmir
#20
Mumtaz Ali Khan, Muhammad Ishaq, Mujeeb Ur Rehman, Asim Altaf, Mirza Aamir Baig, Safdar Rana, Jaleel Kamran, Muazam Abbas Ranjha, Jawad Asgher Rana
BACKGROUND: Middle East Respiratory-Corona virus (MERS-CoV), SARS like virus, identified in September 2012 in Middle-East. February 2013, an elderly man, who visited Pakistan and KSA, was confirmed as MRS-CoV in UK. A team visited Mirpur to assess current and past SARI trends in major indoor facilities, to explore possible contact of the patient with known or suspected SARI case during his stay in Pakistan and enlist close contacts. METHODS: Review of indoor records in hospitals, interviews with relatives & physicians and active contact tracing using operational case definition...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
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