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https://www.readbyqxmd.com/read/29339515/mers-cov-and-h5n1-influenza-virus-antagonize-antigen-presentation-by-altering-the-epigenetic-landscape
#1
Vineet D Menachery, Alexandra Schäfer, Kristin E Burnum-Johnson, Hugh D Mitchell, Amie J Eisfeld, Kevin B Walters, Carrie D Nicora, Samuel O Purvine, Cameron P Casey, Matthew E Monroe, Karl K Weitz, Kelly G Stratton, Bobbie-Jo M Webb-Robertson, Lisa E Gralinski, Thomas O Metz, Richard D Smith, Katrina M Waters, Amy C Sims, Yoshihiro Kawaoka, Ralph S Baric
Convergent evolution dictates that diverse groups of viruses will target both similar and distinct host pathways to manipulate the immune response and improve infection. In this study, we sought to leverage this uneven viral antagonism to identify critical host factors that govern disease outcome. Utilizing a systems-based approach, we examined differential regulation of IFN-γ-dependent genes following infection with robust respiratory viruses including influenza viruses [A/influenza/Vietnam/1203/2004 (H5N1-VN1203) and A/influenza/California/04/2009 (H1N1-CA04)] and coronaviruses [severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV)]...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29337997/event-based-surveillance-of-middle-east-respiratory-syndrome-coronavirus-mers-cov-in-bangladesh-among-pilgrims-and-travelers-from-the-middle-east-an-update-for-the-period-2013-2016
#2
A K M Muraduzzaman, Manjur Hossain Khan, Rezina Parveen, Sharmin Sultana, Ahmed Nawsher Alam, Arifa Akram, Mahmudur Rahman, Tahmina Shirin
INTRODUCTION: Every year around 150,000 pilgrims from Bangladesh perform Umrah and Hajj. Emergence and continuous reporting of MERS-CoV infection in Saudi Arabia emphasize the need for surveillance of MERS-CoV in returning pilgrims or travelers from the Middle East and capacity building of health care providers for disease containment. The Institute of Epidemiology, Disease Control & Research (IEDCR) under the Bangladesh Ministry of Health and Family welfare (MoHFW), is responsible for MERS-CoV screening of pilgrims/ travelers returning from the Middle East with respiratory illness as part of its outbreak investigation and surveillance activities...
2018: PloS One
https://www.readbyqxmd.com/read/29336306/mers-cov-spillover-at-the-camel-human-interface
#3
Gytis Dudas, Luiz Max Carvalho, Andrew Rambaut, Trevor Bedford
Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus from camels causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, and while case-based and seroepidemiological studies have been employed extensively throughout the epidemic, viral sequence data have not been utilised to their full potential. Here we use existing MERS-CoV sequence data to explore its phylodynamics in two of its known major hosts, humans and camels...
January 16, 2018: ELife
https://www.readbyqxmd.com/read/29329554/correction-to-detection-and-full-genome-characterization-of-two-beta-cov-viruses-related-to-middle-east-respiratory-syndrome-from-bats-in-italy
#4
Ana Moreno, Davide Lelli, Luca De Sabato, Guendalina Zaccaria, Arianna Boni, Enrica Sozzi, Alice Prosperi, Antonio Lavazza, Eleonora Cella, Maria Rita Castrucci, Massimo Ciccozzi, Gabriele Vaccari
After Publication of the article [1], it has been brought to our attention that an author's name has been spelt incorrectly. The correct spelling should be "Massimo Ciccozzi", but it was previously included as "Massimo Cicozzi". The original version has now been revised to reflect this.
January 12, 2018: Virology Journal
https://www.readbyqxmd.com/read/29299151/analysis-of-the-codon-usage-pattern-in-middle-east-respiratory-syndrome-coronavirus
#5
Ye Chen, Quanming Xu, Xiaomin Yuan, Xinxin Li, Ting Zhu, Yanmei Ma, Ji-Long Chen
Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which first broken out in Jeddah in 2012, causes a severe acute respiratory illness with a high mortality rate. To better understand the molecular characteristics of isolated MERS-CoV genomes, we first analysed the codon usage pattern of the zoonotic MERS-CoV strains comprehensively to gain an insight into the mechanism of cross-species transmission. We found that MERS human/camel isolates showed a low codon usage bias. Both mutation and nature selection pressure have contributed to this low codon usage bias, with the former being the main determining factor...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29258555/detection-and-full-genome-characterization-of-two-beta-cov-viruses-related-to-middle-east-respiratory-syndrome-from-bats-in-italy
#6
Ana Moreno, Davide Lelli, Luca de Sabato, Guendalina Zaccaria, Arianna Boni, Enrica Sozzi, Alice Prosperi, Antonio Lavazza, Eleonora Cella, Maria Rita Castrucci, Massimo Cicozzi, Gabriele Vaccari
BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV), which belongs to beta group of coronavirus, can infect multiple host species and causes severe diseases in humans. Multiple surveillance and phylogenetic studies suggest a bat origin. In this study, we describe the detection and full genome characterization of two CoVs closely related to MERS-CoV from two Italian bats, Pipistrellus kuhlii and Hypsugo savii. METHODS: Pool of viscera were tested by a pan-coronavirus RT-PCR...
December 19, 2017: Virology Journal
https://www.readbyqxmd.com/read/29249267/coronaviruses-and-arteriviruses-display-striking-differences-in-their-cyclophilin-a-dependence-during-replication-in-cell-culture
#7
Adriaan H de Wilde, Jessika C Zevenhoven-Dobbe, Corrine Beugeling, Udayan Chatterji, Danielle de Jong, Philippe Gallay, Karoly Szuhai, Clara C Posthuma, Eric J Snijder
Cyclophilin A (CypA) is an important host factor in the replication of a variety of RNA viruses. Also the replication of several nidoviruses was reported to depend on CypA, although possibly not to the same extent. These prior studies are difficult to compare, since different nidoviruses, cell lines and experimental set-ups were used. Here, we investigated the CypA dependence of three distantly related nidoviruses that can all replicate in Huh7 cells: the arterivirus equine arteritis virus (EAV), the alphacoronavirus human coronavirus 229E (HCoV-229E), and the betacoronavirus Middle East respiratory syndrome coronavirus (MERS-CoV)...
December 14, 2017: Virology
https://www.readbyqxmd.com/read/29246504/a-recombinant-vsv-vectored-mers-cov-vaccine-induces-neutralizing-antibody-and-t-cell-responses-in-rhesus-monkeys-after-single-dose-immunization
#8
Renqiang Liu, Jinliang Wang, Yu Shao, Xijun Wang, Huilei Zhang, Lei Shuai, Jinying Ge, Zhiyuan Wen, Zhigao Bu
Middle East respiratory syndrome coronavirus (MERS-CoV) has been a highly threatening zoonotic pathogen since its outbreak in 2012. Similar to SARS-CoV, MERS-CoV belongs to the coronavirus family and can induce severe respiratory symptoms in humans, with an average case fatality rate of 35% according to the World Health Organization. Spike (S) protein of MERS-CoV is immunogenic and can induce neutralizing antibodies, thus is a potential major target for vaccine development. Here we constructed a chimeric virus based on the vesicular stomatitis virus (VSV) in which the G gene was replaced by MERS-CoV S gene (VSVΔG-MERS)...
December 12, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29239484/inactivation-of-middle-east-respiratory-syndrome-coronavirus-in-human-plasma-using-amotosalen-and-ultraviolet-a-light
#9
Salwa I Hindawi, Anwar M Hashem, Ghazi A Damanhouri, Sherif A El-Kafrawy, Ahmed M Tolah, Ahmed M Hassan, Esam I Azhar
BACKGROUND: Middle East respiratory syndrome-coronavirus (MERS-CoV) is a novel zoonotic pathogen. Although the potential for MERS-CoV transmission through blood transfusion is not clear, MERS-CoV was recognized as a pathogen of concern for the safety of the blood supply especially after its detection in whole blood, serum, and plasma of infected individuals. Here we investigated the efficacy of amotosalen and ultraviolet A light (UVA) to inactivate MERS-CoV in fresh-frozen plasma (FFP)...
December 14, 2017: Transfusion
https://www.readbyqxmd.com/read/29239118/zoonotic-origin-and-transmission-of-middle-east-respiratory-syndrome-coronavirus-in-the-uae
#10
C R Paden, M F B M Yusof, Z M Al Hammadi, K Queen, Y Tao, Y M Eltahir, E A Elsayed, B A Marzoug, O K A Bensalah, A I Khalafalla, M Al Mulla, K A Elkheir, Z B Issa, K Pradeep, F N Elsaleh, H Imambaccus, J Sasse, S Weber, M Shi, J Zhang, Y Li, H Pham, L Kim, A J Hall, S I Gerber, F I Al Hosani, S Tong, S S M Al Muhairi
Since the emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012, there have been a number of clusters of human-to-human transmission. These cases of human-to-human transmission involve close contact and have occurred primarily in healthcare settings, and they are suspected to result from repeated zoonotic introductions. In this study, we sequenced whole MERS-CoV genomes directly from respiratory samples collected from 23 confirmed MERS cases in the United Arab Emirates (UAE). These samples included cases from three nosocomial and three household clusters...
December 13, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/29235956/the-experience-of-korean-nurses-during-the-middle-east-respiratory-syndrome-outbreak
#11
Sook-Bin Im, Steven L Baumann, Mina Ahn, Hyunok Kim, Bock-Hui Youn, MinKyoung Park, Ok-Ja Lee
The authors in this article explore the experiences of eight South Korean nurses during an outbreak of the Middle East Respiratory Syndrome (MERS), which took place in the fall of 2015. These nurses were mandated to remain in isolation in an intensive care unit (ICU) dedicated to the treatment of the patients with the MERS virus for 7 days. Parse's humanbecoming theory was used to frame the discussion. Three themes found in the nurse's stories are discussed: feeling hopeless and cut off, feeling shame and overworked, and feeling pride in fulfilling a duty...
January 2018: Nursing Science Quarterly
https://www.readbyqxmd.com/read/29232459/definitive-diagnosis-in-suspected-middle-east-respiratory-syndrome-coronavirus-cases
#12
Elisa Rubio, Miguel J Martínez, Verónica Gonzalo, Josep Barrachina, Núria Torner, Ana I Martínez, Mireia Jané, Anna Vilella, Ana Del Rio, Natalia Rodriguez-Valero, Maria Jesús Pinazo, José Muñoz, Alex Soriano, Antoni Trilla, Jordi Vila, Ma Ángeles Marcos
We evaluated the microbiological diagnosis in 14 patients with epidemiological and clinical suspicion of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) attended in a non-endemic area between June 2015 and January 2017. While no MERS-CoV was detected, other respiratory viruses were identified in 12 cases and Mycoplasma pneumoniae in 1 case.
January 1, 2018: Journal of Travel Medicine
https://www.readbyqxmd.com/read/29228581/a-multiplex-liquid-chip-assay-based-on-luminex-xmap-technology-for-simultaneous-detection-of-six-common-respiratory-viruses
#13
Yong Yan, Jian-Yong Luo, Yin Chen, Heng-Hui Wang, Guo-Ying Zhu, Pei-Yan He, Jin-Lei Guo, Yong-Liang Lei, Zhong-Wen Chen
We utilized one-step multiplex reverse transcription-PCR (RT-PCR) and Luminex xMAP technology to develop a respiratory multiplex liquid-chip assay (rMLA) for simultaneous detection of 6 common respiratory viruses, including influenza virus type A (FluA) and type B (FluB), para-influenza virus type 3 (PIV-3), respiratory syncytial virus (RSV), human metapneumovirus (MPV) and a threatening virus to China, Middle East Respiratory Syndrome coronavirus (MERS-CoV). Performance of rMLA was evaluated by comparing with real-time RT-PCR...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207494/an-opportunistic-pathogen-afforded-ample-opportunities-middle-east-respiratory-syndrome-coronavirus
#14
REVIEW
Ian M Mackay, Katherine E Arden
The human coronaviruses (CoV) include HCoV-229E, HCoV-OC43, HCoV-NL63, and HCoV-HKU1, some of which have been known for decades. The severe acute respiratory syndrome (SARS) CoV briefly emerged into the human population but was controlled. In 2012, another novel severely human pathogenic CoV-the Middle East Respiratory Syndrome (MERS)-CoV-was identified in the Kingdom of Saudi Arabia; 80% of over 2000 human cases have been recorded over five years. Targeted research remains key to developing control strategies for MERS-CoV, a cause of mild illness in its camel reservoir...
December 2, 2017: Viruses
https://www.readbyqxmd.com/read/29201911/transmissible-gastroenteritis-virus-papain-like-protease-1-antagonizes-production-of-interferon-%C3%AE-through-its-deubiquitinase-activity
#15
Xiaoliang Hu, Jin Tian, Hongtao Kang, Dongchun Guo, Jiasen Liu, Dafei Liu, Qian Jiang, Zhijie Li, Juanjuan Qu, Liandong Qu
Coronaviruses (CoVs), such as human coronavirus NL63 (HCoV-NL63), severe acute respiratory syndrome CoV (SARS-CoV), murine hepatitis virus (MHV), porcine epidemic diarrhea virus (PEDV), and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), encode papain-like (PL) proteases that inhibit Sendai virus- (SeV-) induced interferon (IFN-β) production. Recently, the crystal structure of transmissible gastroenteritis virus (TGEV) PL1 has been solved, which was similar to that of SARS-CoV PL2pro, which may antagonize host innate immunity...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29199039/the-coronavirus-nucleocapsid-protein-is-adp-ribosylated
#16
Matthew E Grunewald, Anthony R Fehr, Jeremiah Athmer, Stanley Perlman
ADP-ribosylation is a common post-translational modification, although how it modulates RNA virus infection is not well understood. While screening for ADP-ribosylated proteins during coronavirus (CoV) infection, we detected a ~55kDa ADP-ribosylated protein in mouse hepatitis virus (MHV)-infected cells and in virions, which we identified as the viral nucleocapsid (N) protein. The N proteins of porcine epidemic diarrhea virus (PEDV), severe acute respiratory syndrome (SARS)-CoV and Middle East respiratory syndrome (MERS)-CoV were also ADP-ribosylated...
November 30, 2017: Virology
https://www.readbyqxmd.com/read/29186061/identification-of-alpha-and-beta-coronavirus-in-wildlife-species-in-france-bats-rodents-rabbits-and-hedgehogs
#17
Elodie Monchatre-Leroy, Franck Boué, Jean-Marc Boucher, Camille Renault, François Moutou, Meriadeg Ar Gouilh, Gérald Umhang
Coronaviruses are closely monitored in the context of emerging diseases and, as illustrated with Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) and Middle East Respiratory Syndrome-coronavirus (MERS-CoV), are known to cross the species barrier and eventually to move from wildlife to humans. Knowledge of the diversity of coronaviruses in wildlife is therefore essential to better understand and prevent emergence events. This study explored the presence of coronaviruses in four wild mammal orders in France: Bats, rodents, lagomorphs, and hedgehogs...
November 29, 2017: Viruses
https://www.readbyqxmd.com/read/29170916/development-of-small-molecule-viral-inhibitors-targeting-various-stages-of-the-life-cycle-of-emerging-and-re-emerging-viruses
#18
REVIEW
Xiaohuan Wang, Peng Zou, Fan Wu, Lu Lu, Shibo Jiang
In recent years, unexpected outbreaks of infectious diseases caused by emerging and re-emerging viruses have become more frequent, which is possibly due to environmental changes. These outbreaks result in the loss of life and economic hardship. Vaccines and therapeutics should be developed for the prevention and treatment of infectious diseases. In this review, we summarize and discuss the latest progress in the development of small-molecule viral inhibitors against highly pathogenic coronaviruses, including severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, Ebola virus, and Zika virus...
November 23, 2017: Frontiers of Medicine
https://www.readbyqxmd.com/read/29169817/the-french-infectious-diseases-society-s-readiness-and-response-to-epidemic-or-biological-risk-the-current-situation-following-the-middle-east-respiratory-syndrome-coronavirus-and-ebola-virus-disease-alerts
#19
H Coignard-Biehler, C Rapp, J M Chapplain, B Hoen, D Che, P Berthelot, F Cazenave-Roblot, C Rabaud, P Brouqui, C Leport
CONTEXT: In 2012, the French Infectious Diseases Society (French acronym SPILF) initiated the "Coordination of epidemic and biological risk" (SPILF-COREB - Emergences [SCE]) group to support the readiness and response of healthcare workers (HCWs) to new alerts. OBJECTIVE: To present the SCE group, its functioning, and the main support it provided for frontline HCWs. METHODS: A multidisciplinary group of heads of infectious disease departments from reference hospitals was created to build a network of clinical expertise for care, training, and research in the field of epidemic and biological risk (EBR)...
November 20, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29162711/expression-and-cleavage-of-middle-east-respiratory-syndrome-coronavirus-nsp3-4-polyprotein-induce-the-formation-of-double-membrane-vesicles-that-mimic-those-associated-with-coronaviral-rna-replication
#20
Diede Oudshoorn, Kevin Rijs, Ronald W A L Limpens, Kevin Groen, Abraham J Koster, Eric J Snijder, Marjolein Kikkert, Montserrat Bárcena
Betacoronaviruses, such as Middle East respiratory syndrome coronavirus (MERS-CoV), are important pathogens causing potentially lethal infections in humans and animals. Coronavirus RNA synthesis is thought to be associated with replication organelles (ROs) consisting of modified endoplasmic reticulum (ER) membranes. These are transformed into double-membrane vesicles (DMVs) containing viral double-stranded RNA and into other membranous elements such as convoluted membranes, together forming a reticulovesicular network...
November 21, 2017: MBio
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