keyword
MENU ▼
Read by QxMD icon Read
search

middle east respiratory virus

keyword
https://www.readbyqxmd.com/read/29772254/effect-of-interferon-alpha-and-cyclosporine-treatment-separately-and-in-combination-on-middle-east-respiratory-syndrome-coronavirus-mers-cov-replication-in-a-human-in-vitro-and-ex-vivo-culture-model
#1
H S Li, Denise I T Kuok, M C Cheung, Mandy M T Ng, K C Ng, Kenrie P Y Hui, J S Malik Peiris, Michael C W Chan, John M Nicholls
Middle East Respiratory Syndrome Coronavirus (MERS-CoV) has emerged as a coronavirus infection of humans in the past 5 years. Though confined to certain geographical regions of the world, infection has been associated with a case fatality rate of 35%, and this mortality may be higher in ventilated patients. As there are few readily available animal models that accurately mimic human disease, it has been a challenge to ethically determine what optimum treatment strategies can be used for this disease. We used in-vitro and human ex-vivo explant cultures to investigate the effect of two immunomodulatory agents, interferon alpha and cyclosporine, singly and in combination, on MERS-CoV replication...
May 14, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29769348/discovery-and-sequence-analysis-of-four-deltacoronaviruses-from-birds-in-the-middle-east-suggest-interspecies-jumping-and-recombination-as-potential-mechanism-for-avian-to-avian-and-avian-to-mammalian-transmission
#2
Susanna K P Lau, Emily Y M Wong, Chi-Ching Tsang, Syed Shakeel Ahmed, Rex K H Au-Yeung, Kwok-Yung Yuen, Ulrich Wernery, Patrick C Y Woo
The emergence of Middle East respiratory syndrome showed once again that coronaviruses (CoVs) in animals are potential source for epidemics in humans. To explore the diversity of deltacoronaviruses in animals in the Middle East, we tested fecal samples from 1,356 mammals and birds in Dubai. Four novel deltacoronaviruses were detected from eight birds of four species by RT-PCR: FalCoV UAE-HKU27 from a falcon, HouCoV UAE-HKU28 from a houbara bustard, PiCoV UAE-HKU29 from a pigeon and QuaCoV UAE-HKU30 from five quails...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29763640/development-of-fluorescent-reverse-transcription-loop-mediated-isothermal-amplification-rt-lamp-using-quenching-probes-for-the-detection-of-the-middle-east-respiratory-syndrome-coronavirus
#3
Kazuya Shirato, Shohei Semba, Sherif A El-Kafrawy, Ahmed M Hassan, Ahmed M Tolah, Ikuyo Takayama, Tsutomu Kageyama, Tsugunori Notomi, Wataru Kamitani, Shutoku Matsuyama, Esam Ibraheem Azhar
Clinical detection of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) in patients is achieved using genetic diagnostic methods, such as real-time RT-PCR assay. Previously, we developed a reverse transcription-loop-mediated isothermal amplification (RT-LAMP) assay for the detection of MERS-CoV [Virol J. 2014. 11:139]. Generally, amplification of RT-LAMP is monitored by the turbidity induced by precipitation of magnesium pyrophosphate with newly synthesized DNA. However, this mechanism cannot completely exclude the possibility of unexpected reactions...
May 12, 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/29757717/radiographic-and-ct-features-of-viral-pneumonia
#4
Hyun Jung Koo, Soyeoun Lim, Jooae Choe, Sang-Ho Choi, Heungsup Sung, Kyung-Hyun Do
Viruses are the most common causes of respiratory infection. The imaging findings of viral pneumonia are diverse and overlap with those of other nonviral infectious and inflammatory conditions. However, identification of the underlying viral pathogens may not always be easy. There are a number of indicators for identifying viral pathogens on the basis of imaging patterns, which are associated with the pathogenesis of viral infections. Viruses in the same viral family share a similar pathogenesis of pneumonia, and the imaging patterns have distinguishable characteristics...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29753119/replicative-virus-shedding-in-the-respiratory-tract-of-the-patients-with-middle-east-respiratory-syndrome-coronavirus-infection
#5
Wan Beom Park, Leo Lm Poon, Su-Jin Choi, Pyoeng Gyun Choe, Kyoung-Ho Song, Ji Hwan Bang, Eu Suk Kim, Hong Bin Kim, Sang Won Park, Nam Joong Kim, Malik Peiris, Myoung-Don Oh
BACKGROUND: Information on the duration of replicative Middle East respiratory syndrome coronavirus (MERS-CoV) shedding is important for infection control. Detection of MERS-CoV subgenomic mRNAs indicates the virus is replicative. We examined the duration for detecting MERS-CoV subgenomic mRNA compared with genomic RNA in diverse respiratory specimens METHODS: From upper and lower respiratory samples of 17 MERS-CoV-infected patients, MERS-CoV subgenomic mRNA was detected by reverse transcription polymerase chain reaction (RT-PCR) and MERS-CoV genomic RNA was done by real time RT-PCR...
May 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29747397/field-efficacy-of-an-attenuated-infectious-bronchitis-variant-2-virus-vaccine-in-commercial-broiler-chickens
#6
Mohamed A Elhady, Ahmed Ali, Walid H Kilany, Wael K Elfeil, Hytham Ibrahim, Ahmed Nabil, Ahmed Samir, Magdy El Sayed
Egyptian poultry suffer from frequent respiratory disease outbreaks associated with Infectious Bronchitis Virus (IBV) variant 2 strains (Egy/VarII). Different vaccination programs using imported vaccines have failed to protect the flocks from field challenge. Recent studies confirmed a successful protection using homologous strains as live attenuated vaccines. In this study, a newly developed live attenuated IB-VAR2 vaccine representing the GI-23 Middle East IBV lineage was evaluated in day-old commercial broilers in an IBV-endemic area...
May 9, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29739720/heterologous-prime-boost-vaccination-with-adenoviral-vector-and-protein-nanoparticles-induces-both-th1-and-th2-responses-against-middle-east-respiratory-syndrome-coronavirus
#7
Seo-Yeon Jung, Kyung Won Kang, Eun-Young Lee, Dong-Won Seo, Hong-Lim Kim, Hak Kim, TaeWoo Kwon, Hye-Lim Park, Hun Kim, Sang-Myeong Lee, Jae-Hwan Nam
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic and zoonotic virus with a fatality rate in humans of over 35%. Although several vaccine candidates have been developed, there is still no clinically available vaccine for MERS-CoV. In this study, we developed two types of MERS-CoV vaccines: a recombinant adenovirus serotype 5 encoding the MERS-CoV spike gene (Ad5/MERS) and spike protein nanoparticles formulated with aluminum (alum) adjuvant. Next, we tested a heterologous prime-boost vaccine strategy, which compared priming with Ad5/MERS and boosting with spike protein nanoparticles and vice versa, with homologous prime-boost vaccination comprising priming and boosting with either spike protein nanoparticles or Ad5/MERS...
May 5, 2018: Vaccine
https://www.readbyqxmd.com/read/29732571/inactivation-of-ebola-virus-and-middle-east-respiratory-syndrome-coronavirus-in-platelet-concentrates-and-plasma-by-ultraviolet-c-light-and-methylene-blue-plus-visible-light-respectively
#8
Markus Eickmann, Ute Gravemann, Wiebke Handke, Frank Tolksdorf, Stefan Reichenberg, Thomas H Müller, Axel Seltsam
BACKGROUND: Ebola virus (EBOV) and Middle East respiratory syndrome coronavirus (MERS-CoV) have been identified as potential threats to blood safety. This study investigated the efficacy of the THERAFLEX UV-Platelets and THERAFLEX MB-Plasma pathogen inactivation systems to inactivate EBOV and MERS-CoV in platelet concentrates (PCs) and plasma, respectively. STUDY DESIGN AND METHODS: PCs and plasma were spiked with high titers of cell culture-derived EBOV and MERS-CoV, treated with various light doses of ultraviolet C (UVC; THERAFLEX UV-Platelets) or methylene blue (MB) plus visible light (MB/light; THERAFLEX MB-Plasma), and assessed for residual viral infectivity...
May 6, 2018: Transfusion
https://www.readbyqxmd.com/read/29717846/recognizing-and-managing-emerging-infectious-diseases-in-the-emergency-department-digest
#9
Ramón Millán, Deepti Thomas-Paulose, Daniel J Egan, Jeffrey Nusbaum, Nachi Gupta
With population shifts, increased travel, and climate change, the spread of emerging and re-emerging infections is increasing. Although encountering a patient with an emerging infection on any given emergency department shift is unlikely, missing a diagnosis could have profound consequences for the patient, healthcare workers, and the patient's close contacts. This review provides a framework to evaluate, diagnose, and treat a returning traveler with suspected Middle East respiratory syndrome, chikungunya virus, or Zika virus-3 recently emerged infections...
May 1, 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29709903/prevention-the-spread-of-norovirus-infection-on-airborne-route-by-using-plasma-assisted-catalytic-technology-pact-device
#10
Yoshimoto Tanaka, Kan Fujino, Gerald Andrew Larkins, Atsushi Osawa, Yuji Hayashi, Satoshi Taharaguchi
Zoonosis becomes a popular word. Highly pathogenic influenza virus (HPI), Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) recently occurred at around Africa, Meddle-East and South-East Asia area, whose virus is classified as airborne. Sterilization capability was investigated by using chemical reactor of PACT device. Test on airborne infection was carried out by Feline Calicivirus Vaccine (FCV) strain F9, which is also surrogated human norovirus. It was found that PACT device could sterilize instantly FCV when passing through the plasma space of PACT device...
April 30, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29698959/lectin-affinity-plasmapheresis-for-middle-east-respiratory-syndrome-coronavirus-and-marburg-virus-glycoprotein-elimination
#11
Benjamin Koch, Patricia Schult-Dietrich, Stefan Büttner, Bijan Dilmaghani, Dario Lohmann, Patrick C Baer, Ursula Dietrich, Helmut Geiger
BACKGROUND/AIMS: Middle East respiratory syndrome coronavirus (MERS-CoV) and Marburg virus (MARV) are among the World Health Organization's top 8 emerging pathogens. Both zoonoses share nonspecific early symptoms, a high lethality rate, and a reduced number of specific treatment options. Therefore, we evaluated extracorporeal virus and glycoprotein (GP) elimination by lectin affinity plasmapheresis (LAP). METHODS: For both MERS-CoV (pseudovirus) as well as MARV (GPs), 4 LAP devices (Mini Hemopurifiers, Aethlon Medical, San Diego, CA, USA) and 4 negative controls were tested...
April 26, 2018: Blood Purification
https://www.readbyqxmd.com/read/29697919/recognizing-and-managing-emerging-infectious-diseases-in-the-emergency-department
#12
Ramón Millán, Deepti Thomas-Paulose, Daniel Egan
With population shifts, increased travel, and climate change, the spread of emerging and re-emerging infections is increasing. Although encountering a patient with an emerging infection on any given emergency department shift is unlikely, missing a diagnosis could have profound consequences for the patient, healthcare workers, and the patient's close contacts. This review provides a framework to evaluate, diagnose, and treat a returning traveler with suspected Middle East respiratory syndrome, chikungunya virus, or Zika virus-3 recently emerged infections...
May 2018: Emergency Medicine Practice
https://www.readbyqxmd.com/read/29680581/middle-east-respiratory-syndrome-coronavirus-risk-factors-and-determinants-of-primary-household-and-nosocomial-transmission
#13
REVIEW
David S Hui, Esam I Azhar, Yae-Jean Kim, Ziad A Memish, Myoung-Don Oh, Alimuddin Zumla
Middle East respiratory syndrome coronavirus (MERS-CoV) is a lethal zoonosis that causes death in 35·7% of cases. As of Feb 28, 2018, 2182 cases of MERS-CoV infection (with 779 deaths) in 27 countries were reported to WHO worldwide, with most being reported in Saudi Arabia (1807 cases with 705 deaths). MERS-CoV features prominently in the WHO blueprint list of priority pathogens that threaten global health security. Although primary transmission of MERS-CoV to human beings is linked to exposure to dromedary camels (Camelus dromedarius), the exact mode by which MERS-CoV infection is acquired remains undefined...
April 18, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29669833/discovery-of-novel-bat-coronaviruses-in-south-china-that-use-the-same-receptor-as-mers-coronavirus
#14
Chu-Ming Luo, Ning Wang, Xing-Lou Yang, Hai-Zhou Liu, Wei Zhang, Bei Li, Ben Hu, Cheng Peng, Qi-Bin Geng, Guang-Jian Zhu, Fang Li, Zheng-Li Shi
Middle East respiratory syndrome coronavirus (MERS-CoV) has represented a human health threat since 2012. Although several MERS-related CoVs, which belong to the same species as MERS-CoV, have been identified from bats, they do not use the MERS-CoV receptor, dipeptidyl peptidase 4 (DPP4). Here, we screened 1059 bat samples from at least 30 bat species collected in different regions in south China and identified 89 strains of lineage C betacoronaviruses, including Tylonycteris pachypus HKU4 , Pipistrellus pipistrellus HKU5, and MERS-related CoVs...
April 18, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29663439/sero-prevalence-of-middle-east-respiratory-syndrome-coronavirus-mers-cov-specific-antibodies-in-dromedary-camels-in-tabuk-saudi-arabia
#15
Rafik Harrath, Faisel M Abu Duhier
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a novel Coronavirus which was responsible of the first case of human acute respiratory syndrome in the Kingdom of Saudi Arabia (KSA), 2012. Dromedary camels are considered as potential reservoirs for the virus and seem to be the only animal host which may transmit the infection to human. Further studies are required to better understand the animal sources of zoonotic transmission route and the risks of this infection. A primary sero-prevalence study of MERS-CoV preexisting neutralizing antibodies in Dromedary camel serum was conducted in Tabuk, western north region of KSA, in order to assess the seopositivity of these animals and to explain their possible role in the transmission of the infection to Human...
April 16, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29649550/healthcare-workers-exposure-to-middle-east-respiratory-syndrome-corona-virus-mers-cov-revision-of-screening-strategies-urgently-needed
#16
Hala Amer, Abdulrahman S Alqahtani, Faisal Alaklobi, Juhaina Altayeb, Ziad A Memish
OBJECTIVES: MERS-CoV continues to cause frequent hospital outbreaks in Saudi Arabia with emergency departments as the initial site of the spread of this virus. METHODS: We assessed the transmission risks of MERS-CoV infection to HCWs in an outbreak in Riyadh. All HCWs with unprotected exposure to confirmed cases were tested after 24hours of exposure. Two negative results for MERS-CoV 3days apart and being free of any suggestive signs and symptoms were used to stop their isolation...
April 9, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29618723/enhanced-protection-in-mice-induced-by-immunization-with-inactivated-whole-viruses-compare-to-spike-protein-of-middle-east-respiratory-syndrome-coronavirus
#17
Yao Deng, Jiaming Lan, Linlin Bao, Baoying Huang, Fei Ye, Yingzhu Chen, Yanfeng Yao, Wenling Wang, Chuan Qin, Wenjie Tan
The persistent public health threat of infection with Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the need for an effective and safe MERS-CoV vaccine. In this study, we prepared and vaccinated mice with either a Spike (S) protein or inactivated whole MERS-CoV (IV) with a combined adjuvant (alum+CpG) as a vaccine formulation. Similar levels of the anti-S protein IgG response and neutralizing activity were induced by both the S protein and IV vaccines. In addition, immune responses against three other structural proteins, the envelope (E), membrane (M), and nucleocapsid (N) proteins, were also detected in sera of mice that received IV...
April 4, 2018: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29593057/multicenter-evaluation-of-the-biofire-filmarray-respiratory-panel-2-for-the-detection-of-viruses-and-bacteria-in-nasopharyngeal-swab-samples
#18
Amy L Leber, Kathy Everhart, Judy A Daly, Aubrey Hopper, Amanda Harrington, Paul Schreckenberger, Kathleen McKinley, Matthew Jones, Kristen Holmberg, Bart Kensinger
The FilmArray® Respiratory Panel 2 (RP2) is a multiplex in vitro diagnostic test for the simultaneous and rapid (∼45 minutes) detection of 22 pathogens directly from nasopharyngeal swab (NPS) samples. It contains updated (and in some instances redesigned) assays that improve upon the FilmArray® Respiratory Panel (RP; version 1.7), with a faster run time. The organisms identified are adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus NL63, coronavirus OC43, human metapneumovirus, human rhinovirus/enterovirus, influenza A, influenza A H1, influenza A H1-2009, influenza A H3, influenza B, parainfluenza virus 1, parainfluenza virus 2, parainfluenza virus 3, parainfluenza virus 4, respiratory syncytial virus, Bordetella pertussis , Chlamydia pneumoniae , and Mycoplasma pneumoniae...
March 28, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29579103/a-metagenomic-viral-discovery-approach-identifies-potential-zoonotic-and-novel-mammalian-viruses-in-neoromicia-bats-within-south-africa
#19
Marike Geldenhuys, Marinda Mortlock, Jacqueline Weyer, Oliver Bezuidt, Ernest C J Seamark, Teresa Kearney, Cheryl Gleasner, Tracy H Erkkila, Helen Cui, Wanda Markotter
Species within the Neoromicia bat genus are abundant and widely distributed in Africa. It is common for these insectivorous bats to roost in anthropogenic structures in urban regions. Additionally, Neoromicia capensis have previously been identified as potential hosts for Middle East respiratory syndrome (MERS)-related coronaviruses. This study aimed to ascertain the gastrointestinal virome of these bats, as viruses excreted in fecal material or which may be replicating in rectal or intestinal tissues have the greatest opportunities of coming into contact with other hosts...
2018: PloS One
https://www.readbyqxmd.com/read/29561166/dynamics-of-interorganizational-public-health-emergency-management-networks-following-the-2015-mers-response-in-south-korea
#20
Kyungwoo Kim, Kyujin Jung
OBJECTIVES: We investigated public health emergency management networks during the recent outbreak of Middle East respiratory syndrome coronavirus that affected more than 17 000 people in South Korea. METHODS: We administered a survey to 169 organizations in order to map the pattern of communication and response networks during the Middle East respiratory syndrome outbreak. We also conducted 11 semistructured interviews with national, regional, and local government officials to comprehend inhibiting and facilitating factors in risk communication and response to the system...
March 1, 2018: Asia-Pacific Journal of Public Health
keyword
keyword
95395
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"