keyword
MENU ▼
Read by QxMD icon Read
search

middle east respiratory virus

keyword
https://www.readbyqxmd.com/read/29143192/middle-east-respiratory-syndrome-and-severe-acute-respiratory-syndrome-current-therapeutic-options-and-potential-targets-for-novel-therapies
#1
REVIEW
Julie Dyall, Robin Gross, Jason Kindrachuk, Reed F Johnson, Gene G Olinger, Lisa E Hensley, Matthew B Frieman, Peter B Jahrling
No specific antivirals are currently available for two emerging infectious diseases, Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). A literature search was performed covering pathogenesis, clinical features and therapeutics, clinically developed drugs for repurposing and novel drug targets. This review presents current knowledge on the epidemiology, pathogenesis and clinical features of the SARS and MERS coronaviruses. The rationale for and outcomes with treatments used for SARS and MERS is discussed...
November 15, 2017: Drugs
https://www.readbyqxmd.com/read/29126397/no-mers-cov-but-positive-influenza-viruses-in-returning-hajj-pilgrims-china-2013-2015
#2
Xuezheng Ma, Fang Liu, Lijuan Liu, Liping Zhang, Mingzhu Lu, Abuduzhayier Abudukadeer, Lingbing Wang, Feng Tian, Wei Zhen, Pengfei Yang, Kongxin Hu
BACKGROUND: There is global health concern that the mass movement of pilgrims to and from Mecca annually could contribute to the international spread of Middle East Respiratory Syndrome Coronavirus (MERS-CoV). In China, about 11,000 Muslim pilgrims participate in the Hajj gathering in Mecca annually. This is the first report of MERS-CoV and respiratory virus molecular screening of returning pilgrims at points of entry in China from 2013 to 2015. METHODS AND RESULTS: A total of 847 returning Hajj pilgrims participated in this study...
November 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29116217/diversity-of-middle-east-respiratory-syndrome-coronaviruses-in-109-dromedary-camels-based-on-full-genome-sequencing-abu-dhabi-united-arab-emirates
#3
Mohammed Farouk Yusof, Krista Queen, Yassir Mohammed Eltahir, Clinton R Paden, Zulaikha Mohamed Abdel Hameed Al Hammadi, Ying Tao, Yan Li, Abdelmalik Ibrahim Khalafalla, Mang Shi, Jing Zhang, Muzammil Sayed Ahmed Elhaj Mohamed, Mahmud Hamed Abd Elaal Ahmed, Ihsaan Abdulwahab Azeez, Oum Keltoum Bensalah, Ziyada Swar Eldahab, Farida Ismail Al Hosani, Susan I Gerber, Aron J Hall, Suxiang Tong, Salama Suhail Al Muhairi
Middle East respiratory syndrome coronavirus (MERS-CoV) was identified on the Arabian Peninsula in 2012 and is still causing cases and outbreaks in the Middle East. When MERS-CoV was first identified, the closest related virus was in bats; however, it has since been recognized that dromedary camels serve as a virus reservoir and potential source for human infections. A total of 376 camels were screened for MERS-Cov at a live animal market in the Eastern Region of the Emirate of Abu Dhabi, UAE. In all, 109 MERS-CoV-positive camels were detected in week 1, and a subset of positive camels were sampled again weeks 3 through 6...
November 8, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/29093093/glycan-shield-and-fusion-activation-of-a-deltacoronavirus-spike-glycoprotein-fine-tuned-for-enteric-infections
#4
Xiaoli Xiong, M Alejandra Tortorici, Joost Snijder, Craig Yoshioka, Alexandra C Walls, Wentao Li, Andrew T McGuire, Félix A Rey, Berend-Jan Bosch, David Veesler
Coronaviruses recently emerged as major human pathogens causing outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome. They utilize the spike (S) glycoprotein anchored in the viral envelope to mediate host attachment and fusion of the viral and cellular membranes to initiate infection. The S protein is a major determinant of the zoonotic potential of coronaviruses and is also the main target of the host humoral immune response. We report here the 3.5 Å resolution cryo-electron microscopy structure of the S glycoprotein trimer from the pathogenic porcine deltacoronavirus (PDCoV), which belongs to the recently identified delta genus...
November 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29061208/retrospective-epidemiological-cluster-analysis-of-the-middle-east-respiratory-syndrome-coronavirus-mers-cov-epidemic-using-open-source-data
#5
N D Darling, D E Poss, M P Schoelen, M Metcalf-Kelly, S E Hill, S Harris
The Middle East respiratory syndrome coronavirus (MERS-CoV) is caused by a novel coronavirus discovered in 2012. Since then, 1806 cases, including 564 deaths, have been reported by the Kingdom of Saudi Arabia (KSA) and affected countries as of 1 June 2016. Previous literature attributed increases in MERS-CoV transmission to camel breeding season as camels are likely the reservoir for the virus. However, this literature review and subsequent analysis indicate a lack of seasonality. A retrospective, epidemiological cluster analysis was conducted to investigate increases in MERS-CoV transmission and reports of household and nosocomial clusters...
October 24, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29031867/influenza-is-more-common-than-middle-east-respiratory-syndrome-coronavirus-mers-cov-among-hospitalized-adult-saudi-patients
#6
Jaffar A Al-Tawfiq, Ali A Rabaan, Kareem Hinedi
BACKGROUND: Since the initial description of Middle East Respiratory Syndrome Coronavirus (MERS-CoV), we adopted a systematic process of screening patients admitted with community acquired pneumonia. Here, we report the result of the surveillance activity in a general hospital in Saudi Arabia over a four year period. MATERIALS AND METHODS: All admitted patients with community acquired pneumonia from 2012 to 2016 were tested for MERS-CoV. In addition, testing for influenza viruses was carried out starting April 2015...
October 12, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29031546/influenza-virus-but-not-mers-coronavirus-circulation-in-iran-2013-2016-comparison-between-pilgrims-and-general-population
#7
Jila Yavarian, Nazanin Zahra Shafiei Jandaghi, Maryam Naseri, Peyman Hemmati, Mohhamadnasr Dadras, Mohammad Mehdi Gouya, Talat Mokhtari Azad
BACKGROUND: The pilgrimage to Mecca and Karbala bring many Muslims to a confined area. Respiratory tract infections are the most common diseases transmitted during mass gatherings in Hajj, Umrah and Karbala. The aim of this study was to determine and compare the prevalence of Middle East respiratory syndrome coronavirus (MERS-CoV) and influenza virus infections among Iranian general population and pilgrims with severe acute respiratory infections (SARI) returning from Mecca and Karbala during 2013-2016...
October 11, 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/29026532/origins-and-pathogenesis-of-middle-east-respiratory-syndrome-associated-coronavirus-recent-advances
#8
REVIEW
Stephen A Goldstein, Susan R Weiss
Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response...
2017: F1000Research
https://www.readbyqxmd.com/read/28993171/cross-sectional-study-of-mers-cov-specific-rna-and-antibodies-in-animals-that-have-had-contact-with-mers-patients-in-saudi-arabia
#9
Samy Kasem, Ibrahim Qasim, Ali Al-Hufofi, Osman Hashim, Ali Alkarar, Ali Abu-Obeida, Albagir Gaafer, Abdelhamid Elfadil, Ahmed Zaki, Ahmed Al-Romaihi, Nasereldeen Babekr, Nadr El-Harby, Raed Hussien, Ali Al-Sahaf, Ali Al-Doweriej, Faisal Bayoumi, Leo L M Poon, Daniel K W Chu, Malik Peiris
BACKGROUND: Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerged coronavirus that is associated with a severe respiratory disease in humans in the Middle East. The epidemiological profiles of the MERS-CoV infections suggest zoonotic transmission from an animal reservoir to humans. METHODS: This study was designed to investigate animal herds associated with Middle East respiratory syndrome (MERS)-infected patients in Saudi Arabia, during the last three years (2014-2016)...
October 6, 2017: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/28993122/characterization-of-novel-monoclonal-antibodies-against-the-mers-coronavirus-spike-protein-and-their-application-in-species-independent-antibody-detection-by-competitive-elisa
#10
Shuetsu Fukushi, Aiko Fukuma, Takeshi Kurosu, Shumpei Watanabe, Masayuki Shimojima, Kazuya Shirato, Naoko Iwata-Yoshikawa, Noriyo Nagata, Kazuo Ohnishi, Manabu Ato, Simenew Keskes Melaku, Hiroshi Sentsui, Masayuki Saijo
Since discovering the Middle East respiratory syndrome coronavirus (MERS-CoV) as a causative agent of severe respiratory illness in the Middle East in 2012, serological testing has been conducted to assess antibody responses in patients and to investigate the zoonotic reservoir of the virus. Although the virus neutralization test is the gold standard assay for MERS diagnosis and for investigating the zoonotic reservoir, it uses live virus and so must be performed in high containment laboratories. Competitive ELISA (cELISA), in which a labeled monoclonal antibody (MAb) competes with test serum antibodies for target epitopes, may be a suitable alternative because it detects antibodies in a species-independent manner...
January 2018: Journal of Virological Methods
https://www.readbyqxmd.com/read/28988778/nmr-structure-and-localization-of-a-large-fragment-of-the-sars-cov-fusion-protein-implications-in-viral-cell-fusion
#11
Mukesh Mahajan, Deepak Chatterjee, Kannaian Bhuvaneswari, Shubhadra Pillay, Surajit Bhattacharjya
The lethal Coronaviruses (CoVs), Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV) and most recently Middle East Respiratory Syndrome Coronavirus, (MERS-CoV) are serious human health hazard. A successful viral infection requires fusion between virus and host cells carried out by the surface spike glycoprotein or S protein of CoV. Current models propose that the S2 subunit of S protein assembled into a hexameric helical bundle exposing hydrophobic fusogenic peptides or fusion peptides (FPs) for membrane insertion...
October 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28984231/transgene-expression-in-the-genome-of-middle-east-respiratory-syndrome-coronavirus-based-on-a-novel-reverse-genetics-system-utilizing-red-mediated-recombination-cloning
#12
Doreen Muth, Benjamin Meyer, Daniela Niemeyer, Simon Schroeder, Nikolaus Osterrieder, Marcel Alexander Müller, Christian Drosten
Middle East respiratory syndrome coronavirus (MERS-CoV) is a high-priority pathogen in pandemic preparedness research. Reverse genetics systems are a valuable tool to study viral replication and pathogenesis, design attenuated vaccines and create defined viral assay systems for applications such as antiviral screening. Here we present a novel reverse genetics system for MERS-CoV that involves maintenance of the full-length viral genome as a cDNA copy inserted in a bacterial artificial chromosome amenable to manipulation by homologue recombination, based on the bacteriophage λ Red recombination system...
October 6, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/28960494/a-study-of-the-probable-transmission-routes-of-mers-cov-during-the-first-hospital-outbreak-in-the-republic-of-korea
#13
S Xiao, Y Li, M Sung, J Wei, Z Yang
Infections caused by the Middle East respiratory syndrome coronavirus (MERS-CoV) are a serious health issue due to their prevalence and associated mortality. However, the transmission routes of the virus remain unclear, and thus, the current recommended control strategies are not evidence based. In this study, we investigated the transmission routes of MERS-CoV during the first nosocomial outbreak in the Republic of Korea in May 2015 using a multi-agent modeling framework. We identified seven hypothesized transmission modes based on the three main transmission routes (long-range airborne, close contact, and fomite)...
September 28, 2017: Indoor Air
https://www.readbyqxmd.com/read/28931677/structurally-guided-removal-of-deisgylase-biochemical-activity-from-papain-like-protease-originating-from-the-middle-east-respiratory-syndrome-virus
#14
Courtney M Daczkowski, Octavia Goodwin, John V Dzimianski, Jonathan J Farhat, Scott D Pegan
Middle East respiratory syndrome coronavirus (MERS-CoV) is an emerging human pathogen that is the causative agent for Middle East respiratory syndrome (MERS). With MERS outbreaks resulting in over 35% fatalities and now spread to 27 countries, MERS-CoV poses a significant on-going threat to global human health. As part of its viral genome, MERS-CoV encodes for a papain-like protease (PLpro) that has been observed to act as a deubiquitinase and deISGylase to antagonize IFN-I immune pathways. This activity is in addition to its viral polypeptide cleavage function...
September 20, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28923942/identification-of-sialic-acid-binding-function-for-the-middle-east-respiratory-syndrome-coronavirus-spike-glycoprotein
#15
Wentao Li, Ruben J G Hulswit, Ivy Widjaja, V Stalin Raj, Ryan McBride, Wenjie Peng, W Widagdo, M Alejandra Tortorici, Brenda van Dieren, Yifei Lang, Jan W M van Lent, James C Paulson, Cornelis A M de Haan, Raoul J de Groot, Frank J M van Kuppeveld, Bart L Haagmans, Berend-Jan Bosch
Middle East respiratory syndrome coronavirus (MERS-CoV) targets the epithelial cells of the respiratory tract both in humans and in its natural host, the dromedary camel. Virion attachment to host cells is mediated by 20-nm-long homotrimers of spike envelope protein S. The N-terminal subunit of each S protomer, called S1, folds into four distinct domains designated S1(A) through S1(D) Binding of MERS-CoV to the cell surface entry receptor dipeptidyl peptidase 4 (DPP4) occurs via S1(B) We now demonstrate that in addition to DPP4, MERS-CoV binds to sialic acid (Sia)...
October 3, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923111/a-novel-coltivirus-related-virus-isolated-from-free-tailed-bats-from-c%C3%A3-te-d-ivoire-is-able-to-infect-human-cells-in-vitro
#16
Sabrina Weiss, Piotr Wojtek Dabrowski, Andreas Kurth, Siv Aina J Leendertz, Fabian H Leendertz
BACKGROUND: Zoonotic transmission events play a major role in the emergence of novel diseases. While such events are virtually impossible to predict, wildlife screening for potential emerging pathogens can be a first step. Driven by recent disease epidemics like severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), and Ebola, bats have gained special interest as reservoirs of emerging viruses. METHODS: As part of a bigger study investigating pathogens in African bats we screened animals for the presence of known and unknown viruses...
September 18, 2017: Virology Journal
https://www.readbyqxmd.com/read/28906003/inclusion-of-mers-spike-protein-elisa-in-algorithm-to-determine-serologic-evidence-of-mers-cov-infection
#17
Suvang Trivedi, Congrong Miao, Mohammad M Al-Abdallat, Aktham Haddadin, Sultan Alqasrawi, Ibrahim Iblan, Mohannad A Nsour, Tarek Alsanouri, Sami S Ali, Brian Rha, Susan I Gerber, Daniel C Payne, Azaibi Tamin, Natalie J Thornburg
The Centers for Disease Control and Prevention (CDC) algorithm for detecting presence of serum antibodies against Middle East Respiratory Syndrome coronavirus (MERS-CoV) in subjects with potential infections with the virus has included screening by indirect ELISA against recombinant nucleocapsid (N) protein and confirmation by immunofluorescent staining of infected monolayers and/or microneutralization titration. Other international groups include indirect ELISA assays using the spike (S) protein, as part of their serological determinations...
September 14, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28902913/identification-of-diverse-viruses-in-upper-respiratory-samples-in-dromedary-camels-from-united-arab-emirates
#18
Yan Li, Abdelmalik Ibrahim Khalafalla, Clinton R Paden, Mohammed F Yusof, Yassir M Eltahir, Zulaikha M Al Hammadi, Ying Tao, Krista Queen, Farida Al Hosani, Susan I Gerber, Aron J Hall, Salama Al Muhairi, Suxiang Tong
Camels are known carriers for many viral pathogens, including Middle East respiratory syndrome coronavirus (MERS-CoV). It is likely that there are additional, as yet unidentified viruses in camels with the potential to cause disease in humans. In this study, we performed metagenomic sequencing analysis on nasopharyngeal swab samples from 108 MERS-CoV-positive dromedary camels from a live animal market in Abu Dhabi, United Arab Emirates. We obtained a total of 846.72 million high-quality reads from these nasopharyngeal swab samples, of which 2...
2017: PloS One
https://www.readbyqxmd.com/read/28885377/clinical-pearls-in-venovenous-extracorporeal-life-support-for-adult-respiratory-failure
#19
Chee Kiang Tay, Kiick Sung, Yang Hyun Cho
Extracorporeal life support (ECLS) has been widely utilized to treat neonatal respiratory failure for two decades. However, its uptake in the case of adult respiratory failure has been slow because of a paucity of quality evidence and a sluggish tempo of ECLS-related technological advances. In recent years, interest in ECLS has been piqued after encouraging results were reported from its use during the 2009 H1N1 influenza pandemic. In a world constantly under threat from another influenza epidemic or deadly novel respiratory infection, e...
September 6, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28875620/mers-cov-infection-in-a-pregnant-woman-in-korea
#20
Soo Young Jeong, Se In Sung, Ji Hee Sung, So Yoon Ahn, Eun Suk Kang, Yun Sil Chang, Won Soon Park, Jong Hwa Kim
Middle East respiratory syndrome (MERS) is a lethal respiratory disease - caused by MERS-coronavirus (MERS-CoV) which was first identified in 2012. Especially, pregnant women can be expected as highly vulnerable candidates for this viral infection. In May 2015, this virus was spread in Korea and a pregnant woman was confirmed with positive result of MERS-CoV polymerase chain reaction (PCR). Her condition was improved only with conservative treatment. After a full recovery of MERS, the patient manifested abrupt vaginal bleeding with rupture of membrane...
October 2017: Journal of Korean Medical Science
keyword
keyword
95395
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"