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Mansour Nazari, Rastgar Hassan
INTRODUCTION: Scorpions are arthropods of medical importance classified in the class Arachnida, inhabiting hot and dry environments. All scorpions have a venomous sting and several thousand people die each year from scorpion stings, but this mortality is due to the venom of about 25 species located in northern Africa, the Middle East, India, Mexico and parts of South America. Poldokhtar County belongs to one of the southern cities of Lorestan Province, providing suitable habitats for many different species of scorpions due to its specific climatic conditions...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
Guillaume Martinez, Jean-Pascal Hograindleur, Sébastien Voisin, Roland Abi Nahed, Tarek M Abd El Aziz, Jessica Escoffier, Julien Bessonnat, Claire-Maëlle Fovet, Michel De Waard, Sylviane Hennebicq, Vincent Aucagne, Pierre F Ray, Eric Schmitt, Philippe Bulet, Christophe Arnoult
STUDY QUESTION: Is it possible to identify original compounds that are able to enhance sperm motility from the venom of the scorpion Scorpio maurus palmatus? SUMMARY ANSWER: We identified a potent disulfide-rich peptide (DRP) of 73 amino acids that significantly improved the motility of fresh and frozen-thawed sperm in different mammalian species, including human, and improved fertilization outcome in mouse IVF experiments. WHAT IS KNOWN ALREADY: Any disturbance of sperm motility has a strong impact on fertilization and can lead to subfertility or infertility...
December 8, 2016: Molecular Human Reproduction
Łukasz Łapaj, Adrian Mróz, Paweł Kokoszka, Jacek Markuszewski, Justyna Wendland, Celina Helak-Łapaj, Jacek Kruczyński
Background and purpose - Severe backside wear, observed in older generations of total knee replacements (TKRs), led to redesign of locking mechanisms to reduce micromotions between tibial tray and inlay. Since little is known about whether this effectively reduces backside wear in modern designs, we examined backside damage in retrievals of various contemporary fixed-bearing TKRs. Patients and methods - A consecutive series of 102 inlays with a peripheral (Stryker Triathlon, Stryker Scorpio, DePuy PFC Sigma, Aesculap Search Evolution) or dovetail locking mechanism (Zimmer NexGen, Smith and Nephew Genesis II) was examined...
February 2017: Acta Orthopaedica
Zdeněk Ďuriš, Chia-Wei Lin
A new species of shrimp Metapontonia scorpio symbiotic with scleractinian coral Diploastrea heliopora is described from Taiwan. The species belongs to the smallest symbiotic shrimps of the family Palaemonidae. It is remarkable by a unique ability to turn its last two pleonites with tail fan dorsally over the 4<sup>th</sup> and preceding pleonal segments, thus resembling scorpions. For such movement, the respective opposing dorsal margins of the 4<sup>th</sup>-6<sup>th</sup> segments are deeply concave...
July 18, 2016: Zootaxa
Li-Li Jiang, Yat-Tung Lo, Wei-Ting Chen, Pang-Chui Shaw
Concentrated Chinese medicine granules (CCMG) offer patients a convenient option for traditional therapy. However with morphological and microscopic characteristics lost, it is difficult to authenticate and control the quality of these medicinal products. This study is the first to examine the feasibility of using DNA techniques to authenticate animal-derived CCMG, which has so far lacking of effective means for authentication. Primers targeting amplicons of different sizes were designed to determine the presence of PCR-amplifiable DNA fragments in two types of CCMG, namely Zaocys and Scorpio...
September 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
Tomoyuki Komai, Tin-Yam Chan
Collections made during the recent expeditions to Papua New Guinea ("BIOPAPUA", 2010; "PAPUA NIUGINI", 2012) yielded a total of 12 species from the "symmetrical" hermit crab family Pylochelidae, including two new to science: Bathycheles incisus (Forest, 1987), B. integer (Forest, 1987), Cheiroplatea laticauda Boas, 1926, C. pumicicola Forest, 1987, C. rotundioculus n. sp., Pylocheles mortensenii Boas, 1926, and Xylocheles macrops (Forest, 1987) (Pylochelinae); Parapylocheles scorpio (Alcock, 1894), Trizocheles manningi Forest, 1987, T...
March 9, 2016: Zootaxa
Amanda M Adams, Eugene Marais, J Scott Turner, Lorenzo Prendini, Berry Pinshow
Many animals reside in burrows that may serve as refuges from predators and adverse environmental conditions. Burrow design varies widely among and within taxa, and these structures are adaptive, fulfilling physiological (and other) functions. We examined the burrow architecture of three scorpion species of the family Scorpionidae: Scorpio palmatus from the Negev desert, Israel; Opistophthalmus setifrons, from the Central Highlands, Namibia; and Opistophthalmus wahlbergii from the Kalahari desert, Namibia. We hypothesized that burrow structure maintains temperature and soil moisture conditions optimal for the behavior and physiology of the scorpion...
August 2016: Die Naturwissenschaften
Qunjie Zhong, Xin Zhi, Jianhao Lin, Houshan Lyu
OBJECTIVE: To evaluate long-term result of Scorpio posterior-stabilized total knee arthroplasty. METHODS: There were 160 patients (240 knees) underwent Scorpio posterior-stabilized total knee arthroplasty between December 1998 and December 2000, which were performed by the same surgeon. Patients were followed up from June 2013 to December 2013. Knee Society Scoring (KSS), Hospital for Special Surgery (HSS) patellofemoral scoring, standard weight-bearing anteroposterior and patellar tangential radiographs were assessed...
April 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
Patrick L Harrison, Mohamed A Abdel-Rahman, Peter N Strong, Mohamed M Tawfik, Keith Miller
Scorpion venoms provide a rich source of anti-microbial peptides. Here we characterise three from the venom of Scorpion maurus palmatus. Smp13 is biologically inactive, despite sharing homology with other antimicrobial peptides, probably because it lacks a typically charged structure. Both Smp-24 and Smp-43 have broad spectrum antimicrobial activity, disrupting bacterial membranes. In addition, there is evidence that Smp24 may inhibit DNA synthesis in Bacillus subtilis. Smp24 haemolysed red blood cells but in contrast, Smp43 was non-haemolytic...
July 2016: Toxicon: Official Journal of the International Society on Toxinology
Pedro Paulo Vissotto de Paiva Diniz, Paulo Eduardo Neves Ferreira Velho, Luiza Helena Urso Pitassi, Marina Rovani Drummond, Bruno Grosselli Lania, Maria Lourdes Barjas-Castro, Stanley Sowy, Edward B Breitschwerdt, Diana Gerardi Scorpio
Bacteria from the genus Bartonella are emerging blood-borne bacteria, capable of causing long-lasting infection in marine and terrestrial mammals, including humans. Bartonella are generally well adapted to their main host, causing persistent infection without clinical manifestation. However, these organisms may cause severe disease in natural or accidental hosts. In humans, Bartonella species have been detected from sick patients presented with diverse disease manifestations, including cat scratch disease, trench fever, bacillary angiomatosis, endocarditis, polyarthritis, or granulomatous inflammatory disease...
March 2016: PLoS Neglected Tropical Diseases
Roman Ciprian Oliviu, Ancuța Zazgyva, Sâmpalean Septimiu, Nagy Örs, Pop Tudor Sorin
OBJECTIVE: Single-radius femoral total knee endoprosthesis designs were introduced with the promise of better clinical and functional results by means of superior biomechanical characteristics. The aim of this study was to compare the mid-term clinical, functional, radiologic, and survivorship outcomes of 2 types of posterior-stabilized knee replacement systems: the single-radius Scorpio® (Stryker®, Mahwah, NJ, USA) and the multi-radius NexGen® (Zimmer®, Warsaw, IN, USA). METHODS: This retrospective observational study included 139 patients (164 knees) that underwent total knee replacement (TKR) between October 2004 and December 2010: 94 knees (75 patients) with Scorpio® and 70 knees (64 patients) with NexGen®...
2016: Acta Orthopaedica et Traumatologica Turcica
Murat Bozkurt, Mesut Tahta, Safa Gursoy, Mustafa Akkaya
PURPOSE: The study aimed to volumetrically measure and compare the bone amount removed through the intercondylar femoral notch and the total bone amount removed through five different brands of implant design in order to provide orthopaedic surgeons with opinions in respect of implant selection. METHODS: Ten implants from five different total knee arthroplasty implant manufacturers, namely Nex-Gen Legacy, Genesis 2 PS, Vanguard, Sigma PS and Scorpio NRG PS, were applied to a total of 50 sawbone models...
November 14, 2015: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Monika Vij, Marcus J Drake
Mirabegron is a β3 adrenoceptor agonist licensed for the treatment of overactive bladder symptoms, such as urinary urgency or urgency incontinence. β3 adrenoceptor activation causes detrusor muscle relaxation, but mirabegron may also act by binding other targets in the bladder, and it may also reduce activity in sensory nerves. Phase III clinical trials (SCORPIO, ARIES, and CAPRICORN) evaluated mirabegron at various doses, demonstrating reduction from baseline to endpoint in mean incontinence episodes and mean number of micturitions per 24 h (coprimary endpoints), along with health-related quality of life and a range of secondary measures...
October 2015: Therapeutic Advances in Urology
Atsushi Takahashi, Takehiko Sugita, Toshimi Aizawa, Daisuke Chiba, Masayuki Kamimura, Takashi Aki, Eiji Itoi
BACKGROUND: During total knee arthroplasty (TKA), excision of the popliteus tendon leads to extensive static gaps and reduced mobility. The purpose of this study was to determine the positional relationship between the femoral insertion of the popliteus tendon and the bone cutting lines of various TKA systems. METHODS: This study included 21 cadaveric right femurs presenting no macroscopic deformity. The lateral image of the femur and the template of the femoral component were overlaid to determine the preservation/excision of the popliteus tendon insertion...
November 2015: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Rolf Teschke
Traditional Chinese Medicine (TCM) is popular around the world and encompasses many different practices with particular emphasis on herbal TCM. Using the PubMed database, a literature search was undertaken to assess the extent herbal TCM products exert rare hepatotoxicity. Analysis of reported cases revealed numerous specified herbal TCM products with potential hepatotoxicity. Among these were An Shu Ling, Bai Fang, Bai Xian Pi, Ban Tu Wan, Bo He, Bo Ye Qing Niu Dan, Bofu Tsu Sho San, Boh Gol Zhee, Cang Er Zi, Chai Hu, Chaso, Chi R Yun, Chuan Lian Zi, Ci Wu Jia, Da Chai Hu Tang, Da Huang, Du Huo, Gan Cao, Ge Gen, Ho Shou Wu, Hu Bohe You, Hu Zhang, Huang Qin, Huang Yao Zi, Hwang Geun Cho, Ji Gu Cao, Ji Ji, Ji Xue Cao, Jiguja, Jin Bu Huan, Jue Ming Zi, Kamishoyosan, Kudzu, Lei Gong Teng, Long Dan Xie Gan Tang, Lu Cha, Ma Huang, Mao Guo Tian Jie Cai, Onshido, Polygonum multiflorum, Qian Li Guang, Ren Shen, Sairei To, Shan Chi, Shen Min, Shi Can, Shi Liu Pi, Shou Wu Pian, Tian Hua Fen, White flood, Wu Bei Zi, Xi Shu, Xiao Chai Hu Tang, Yin Chen Hao, Zexie, Zhen Chu Cao, and various unclassified Chinese herbal mixtures...
June 2014: Journal of Clinical and Translational Hepatology
Marcos Rogério André, John Stephen Dumler, Heitor M Herrera, Luiz R Gonçalves, Keyla Cm de Sousa, Diana Gerardi Scorpio, Ana Cláudia Gabriela Alexandre de Santis, Iara Helena Domingos, Gabriel Carvalho de Macedo, Rosangela Zacarias Machado
OBJECTIVES: The objective of this study was to develop a quantitative 5' nuclease real-time polymerase chain reaction (PCR) assay to diagnose infections caused by Bartonella species. METHODS: Between January and April 2013 whole blood samples were collected by convenience from 151 cats (86 domiciled and 65 stray cats). The feline blood samples were subjected to a novel quantitative 5' nuclease real-time PCR (qPCR) for Bartonella species targeting the nictonamide adenine dinucleotide dehydrogenase gamma subunit (nuoG) and conventional PCR assays targeting intergenic transcribed spacer, ribC, gltA, pap31 and rpoB, followed by sequencing and basic local alignment search tool analysis...
October 2016: Journal of Feline Medicine and Surgery
Richard N de Steiger, Orhun Muratoglu, Michelle Lorimer, Alana R Cuthbert, Stephen E Graves
BACKGROUND AND PURPOSE: While highly crosslinked polyethylene has shown reduced in vivo wear and lower rates of revision for total hip arthroplasty, there have been few long-term studies on its use in total knee arthroplasty (TKA). We compared the rate of revision of non-crosslinked polyethylene to that of crosslinked polyethylene in patients who underwent TKA for osteoarthritis. PATIENTS AND METHODS: We examined data from the Australian Orthopaedic Association National Joint Replacement Registry on 302,214 primary TKA procedures with non-crosslinked polyethylene and 83,890 procedures with crosslinked polyethylene, all of which were performed for osteoarthritis...
2015: Acta Orthopaedica
Stav Talal, Itay Tesler, Jaim Sivan, Rachel Ben-Shlomo, H Muhammad Tahir, Lorenzo Prendini, Sagi Snir, Eran Gefen
Scorpio Linnaeus, 1758 (family Scorpionidae Latreille, 1802) was considered monotypic for over a century, and comprised a single species, Scorpio maurus Linnaeus, 1758, with 19 subspecies, distributed from West Africa, throughout the Maghreb and the Middle East, to Iran. Two parapatric subspecies, Scorpio maurus fuscus (Ehrenberg, 1829) and Scorpio maurus palmatus (Ehrenberg, 1828), have long been recognized in the eastern Mediterranean region. We examined morphological variation, burrow architecture and genetic divergence among 39 populations across the distribution of the two subspecies to assess whether they are conspecific and, if not, how many species might be involved...
October 2015: Molecular Phylogenetics and Evolution
Alaa M H El-Bitar, Moustafa M H Sarhan, Chie Aoki, Yusuke Takahara, Mari Komoto, Lin Deng, Mohsen A Moustafa, Hak Hotta
BACKGROUND: Hepatitis C virus (HCV) is a major global health problem, causing chronic hepatitis, liver cirrhosis and hepatocellular carcinoma. Development of well-tolerated regimens with high cure rates and fewer side effects is still much needed. Recently, natural antimicrobial peptides (AMPs) are attracting more attention as biological compounds and can be a good template to develop therapeutic agents, including antiviral agents against a variety of viruses. Various AMPs have been characterized from the venom of different venomous animals including scorpions...
2015: Virology Journal
A Martin, C Quah, G Syme, K Lammin, N Segaren, S Pickering
BACKGROUND: The Scorpio Total Knee Replacement (TKR) is one of the most commonly used prosthesis in the United Kingdom. Concerns arose at our institution that there was a high revision rate for this prosthesis. No study has assessed survivorship of this prosthesis over 10 years. METHODS: Four hundred and fifty-six consecutive patients, who underwent a primary Scorpio TKR, were clinically and radiologically evaluated. WOMAC, Oxford Knee Score and all complications including the reason for revision surgery were recorded...
June 2015: Knee
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