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Unexplained infertility

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https://www.readbyqxmd.com/read/27933646/antisperm-antibodies-in-repeat-breeding-cows-frequency-detection-and-validation-of-threshold-levels-employing-sperm-immobilization-sperm-agglutination-and-immunoperoxidase-assay
#1
S K Srivastava, S Shinde, S K Singh, S Mehrotra, M R Verma, A K Singh, S Nandi, N Srivastava, S K Singh, T K Goswami, S K Bhure, H Kumar, S K Ghosh
Antisperm antibodies have been found in repeat-breeding(RB) cows, and those causing agglutination and/or immobilization of sperm are considered to be closely related to unexplained infertility. However, a standard protocol for identifying antisperm antibodies (ASA) in cattle is not validated. Therefore, an investigation was undertaken to evaluate sperm immobilization (SIT), sperm agglutination (SAT) and immunoperoxidase (IPT)assays for detection of ASA in serum and their respective threshold levels for confirmation...
December 8, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27933295/sperm-chromatin-dispersion-test-before-sperm-preparation-is-predictive-of-clinical-pregnancy-in-cases-of-unexplained-infertility-treated-with-intrauterine-insemination-and-induction-with-clomiphene-citrate
#2
Frank W R C Vandekerckhove, Ilse De Croo, Jan Gerris, Etienne Vanden Abbeel, Petra De Sutter
BACKGROUND/AIMS: A large proportion of men with normal sperm results as analyzed using conventional techniques have fragmented DNA in their spermatozoa. We performed a prospective study to examine the incidence of DNA fragmentation in sperm in cases of couples with previously unexplained infertility and treated with intrauterine insemination. We evaluated whether there was any predictive value of DNA fragmentation for pregnancy outcome in such couples. METHODS: The percentage of DNA fragmentation and all classical variables to evaluate sperm before and after sperm treatment were determined...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27932897/effect-of-ovarian-endometrioma-on-uterine-and-ovarian-blood-flow-in-infertile-women
#3
Akmal El-Mazny, Ahmed Kamel, Wafaa Ramadan, Sherine Gad-Allah, Suzy Abdelaziz, Ahmed M Hussein
BACKGROUND: Angiogenesis has been found to be among the most important factors in the pathogenesis of endometriosis. The formation of new blood vessels is critical for the survival of newly implanted endometriotic foci. The use of 3-D power Doppler allows for the demonstration of the dynamic vascular changes that occur during the process of in vitro fertilization (IVF). We aimed to evaluate the effect of ovarian endometrioma on uterine and ovarian blood flow in infertile women. MATERIALS AND METHODS: In a case-control study at a university teaching hospital, 138 women with unilateral ovarian endometrioma scheduled for IVF were compared to 138 women with male-factor or unexplained infertility...
2016: International Journal of Women's Health
https://www.readbyqxmd.com/read/27932281/nutcracker-syndrome-a-rare-cause-of-left-flank-pain-that-can-also-manifest-as-unexplained-pelvic-pain
#4
Jean-Marie Berthelot, Frédéric Douane, Yves Maugars, Eric Frampas
Nutcracker syndrome (NCS) is symptomatic unilateral renal venous hypertension due to compression of the left renal vein between the superior mesenteric artery and aorta (anterior NCS) or between the aorta and spine (posterior NCS). The left ovarian or spermatic vein empties into the left renal vein and is an additional site of venostasis in about half the cases of NCS. The presenting symptom of NCS in about half the cases is atypical left flank pain suggesting a disorder of the lower ribs or thoracolumbar spinal junction, particularly as the pain worsens with standing and increased lumbar lordosis...
December 5, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27908224/serum-substance-p-concentrations-to-predict-oocyte-maturation-index-and-clinical-pregnancy
#5
Yavuz Sahin, Enis Özkaya, Semra Kayatas Eser, Tayfun Kutlu, Ilhan Sanverdi, Gulden Tunali, Ates Karateke
AIM: The aim of this study was to assess the predictive value of serum substance P (SP) concentrations on oocyte maturation and clinical pregnancy. METHODS: Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for each participant and at the day of oocyte pick up, serum samples were obtained from each participant to assess SP concentrations, and these concentrations were utilized to predict mature/total oocyte ratio and clinical pregnancy...
December 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27895545/studying-the-complex-relationships-between-physical-activity-and-infertility
#6
Kelly R Evenson, Kathryn R Hesketh
This article provides commentary on the accompanying review, "Modifiable Risk Factors and Infertility: What are the Connections?" by Rossi and colleagues. This commentary focuses specifically on the association between physical activity or exercise and infertility, given the equivocal evidence summarized in the Rossi et al. review paper. Several methodologic issues related to physical activity and infertility are discussed, including defining the components of physical activity that research studies assess in research studies (e...
July 2016: American Journal of Lifestyle Medicine
https://www.readbyqxmd.com/read/27891185/spermatozoal-cell-death-inducing-dna-fragmentation-factor-%C3%AE-like-effector-a-cidea-gene-expression-and-dna-fragmentation-in-infertile-men-with-metabolic-syndrome-and-normal-seminogram
#7
Ayman Z Elsamanoudy, Hussein Abdelaziz Abdalla, Mohammed Hassanien, Mohammad A Gaballah
BACKGROUND: This is the first study to investigate spermatozoal cell death-inducing DNA fragmentation factor-α-like effector A (CIDEA) gene expression and DNA fragmentations in the spermatozoa of men diagnosed with metabolic syndrome (MS) who have normal seminograms with unexplained infertility, and to correlate these parameters with seminal glucose concentration. METHODS: This study included 120 participants: 75 male subjects with MS (38 fertile and 37 infertile), and a control group of 45 fertile males without MS...
2016: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/27873054/expectant-management-may-reduce-overtreatment-in-women-affected-by-unexplained-infertility-confirmed-by-diagnostic-laparoscopy
#8
S De Cicco, Valeria Tagliaferri, L Selvaggi, D Romualdi, C Di Florio, V Immediata, A Lanzone, M Guido
PURPOSE: To determine whether the mini-invasive surgery still play a role in the diagnostic workup and in the management of the couples affected by unexplained infertility. METHODS: 170 infertile women (age range 25-38 years) with documented normal ovarian, tubal and uterine function underwent combined hysteroscopic and laparoscopic surgery; 100 women refused surgery or ART treatment (control group) choosing expectant management. A retrospective assessment questionnaire was proposed to enrolled women to collect the rate of spontaneous or ART-induced pregnancies...
November 21, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27867306/case-report-of-ectopic-ovarian-pregnancy-following-fresh-embryo-transfer
#9
Nivin Samara, Yaakov Bentov
BACKGROUND: Ovarian pregnancy is a rare and challenging clinical phenomenon. Recent studies have identified assisted reproductive treatments and infertility as risk factors. However, neither a definite mechanism nor clear risk factors were identified and therefore prevention strategies are yet unavailable. CLINICAL CASE: In this article, we present a case of ovarian pregnancy occurring following in vitro fertilization treatment and a fresh embryo transfer. The couple was diagnosed with unexplained infertility and no identifiable risk factors for extrauterine pregnancy...
2016: Clinical Medicine Insights. Reproductive Health
https://www.readbyqxmd.com/read/27864361/causes-of-male-infertility-a-9-year-prospective-monocentre-study-on-1737-patients-with-reduced-total-sperm-counts
#10
M Punab, O Poolamets, P Paju, V Vihljajev, K Pomm, R Ladva, P Korrovits, M Laan
STUDY QUESTION: What are the primary causes of severe male factor infertility? SUMMARY ANSWER: Although 40% of all patients showed primary causes of infertility, which could be subdivided into three groups based on the severity of their effect, ~75% of oligozoospermia cases remained idiopathic. WHAT IS KNOWN ALREADY: There are few large-scale epidemiological studies analyzing the causes of male factor infertility. STUDY DESIGN, SIZE, DURATION: A prospective clinical-epidemiological study was conducted at the Andrology Centre, Tartu University Hospital between 2005 and 2013, recruiting male partners of couples failing to conceive a child for over ≥12 months...
November 17, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27855570/genetics-of-suspected-thrombophilia-in-serbian-females-with-infertility-including-three-cases-homozygous-for-fii-20210a-or-fv-1691a-mutations
#11
Jelena Djurovic, Oliver Stojkovic, Jelena Todorovic, Aleksandra Brajic, Sanja Stankovic, Svetlana Obradovic, Gorana Stamenkovic
Reproductive failure (recurrent foetal loss, unexplained infertility and IVF implantation failure) may be, in a number of cases, explained by thrombophilia, either acquired or inherited. Several genes contribute to thrombophilia, some with major effect (Factor V, Factor II), and some with minor effect (MTHFR, PAI-1, ATIII, etc.). The aim of this study was to estimate frequency of thrombophilia-associated genotypes (FII20210G > A, FV1691G > A, MTHFR677C > T and PAI-1 -675 4G/5G) in a group of 1631 Serbian women experiencing reproductive failure, and compare it with a healthy, female control group...
November 18, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27852632/predicting-the-chances-of-a-live-birth-after-one-or-more-complete-cycles-of-in-vitro-fertilisation-population-based-study-of-linked-cycle-data-from-113%C3%A2-873-women
#12
David J McLernon, Ewout W Steyerberg, Egbert R Te Velde, Amanda J Lee, Siladitya Bhattacharya
OBJECTIVE:  To develop a prediction model to estimate the chances of a live birth over multiple complete cycles of in vitro fertilisation (IVF) based on a couple's specific characteristics and treatment information. DESIGN:  Population based cohort study. SETTING:  All licensed IVF clinics in the UK. National data from the Human Fertilisation and Embryology Authority register. PARTICIPANTS:  All 253 417 women who started IVF (including intracytoplasmic sperm injection) treatment in the UK from 1999 to 2008 using their own eggs and partner's sperm...
November 16, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27809622/nitric-oxide-donors-increase-the-pregnancy-rate-in-patients-with-unexplained-infertility-undergoing-clomiphene-citrate-stimulation-and-intrauterine-insemination-a-randomized-controlled-pilot-study
#13
Mohamed Abdel Razik, Seham El-Berry, Ahmed El-Nezamy, Ahmed Saad, Ahmed Abdel Wahab
This study evaluated the effects of nitric oxide donor's treatment on the pregnancy rate and uterine blood flow in patients with unexplained infertility undergoing clomiphene citrate stimulation and intrauterine insemination. A total of 120 patients were randomly allocated to a control group who received 100 mg clomiphene citrate daily from day 5 to 9 of cycle plus placebo vaginal tablets, and a study group received clomiphene citrate plus isosorbide mononitrate 10 mg vaginal tablets. Vaginal ultrasound was done before treatment and every other day starting from day 12 of cycle to count mature follicles and ovulation was triggered by IM injection of 10 000 IU hCG when one follicle measured 18 ≥ mm followed by intrauterine insemination after 36 h...
November 4, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27806819/secondary-infertility-due-to-retained-fetal-bones-diagnosed-via-saline-sonography
#14
Rubina Izhar, Samia Husain, Suhaima Tahir, Sonia Husain
Prolonged intrauterine retention of any fetal bones can lead to secondary infertility. The exact incidence remains unclear. This case report describes a 36-year woman with secondary infertility of eight years. Workup revealed echogenic foci partially embedded in endometrium on saline sonography. After ultrasound guided dilation and curettage, fetal bones were retrieved. Unexplained infertility can often be explained if before applying this label, uterine factor is also taken into account. When common causes like tubal blockage, male factor, and ovulatory dysfunction have been excluded, infrequent causes like polyps, adhesions, and in rare instances foreign bodies also should be looked for...
October 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27803588/ficoll-400-density-gradient-method-as-an-effective-sperm-preparation-technique-for-assisted-reproductive-techniques
#15
Hyacinth N Highland, A Sharma Rishika, S Shaikh Almira, P Bansal Kanthi
BACKGROUND: Infertility being a burning issue, the male itself contributes about 40% as a cause, as evident by statistical data. However, Assisted Reproductive Technology (ART) has emerged as a powerful tool in the management of infertility. Sperm preparation techniques govern the selection procedure to separate functional spermatozoa which can then be used in IUI, IVF, and ART and for cryopreservation. AIM: The present study was aimed at evaluation of sperm preparation techniques for reliability, performance and to determine the most effective, feasible and economical technique...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27803582/impact-of-gonadotropin-releasing-hormone-antagonist-addition-on-pregnancy-rates-in-gonadotropin-stimulated-intrauterine-insemination-cycles
#16
Shikha Jain, Abha Majumdar
OBJECTIVES: The objective of the study is to evaluate the efficacy of gonadotropin-releasing hormone (GnRH) antagonist in improving clinical pregnancy rate in gonadotropin-stimulated intrauterine insemination (IUI) cycles in patients of unexplained infertility. STUDY DESIGN: This was a prospective, randomized case-controlled study. SETTINGS: The study was conducted in the infertility clinic of a tertiary care center. MATERIALS AND METHODS: Four hundred twenty-seven women undergoing IUI following controlled ovarian stimulation with gonadotropins (recombinant follicle-stimulating hormone [r-FSH] 75 IU/day) were randomly divided into two groups...
July 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/27796894/telocytes-in-inflammatory-gynaecologic-diseases-and-infertility
#17
Xiao-Jun Yang
Women suffered with inflammatory gynecologic diseases, such as endometriosis (EMs) and acute salpingitis (AS) often complained of sub- or infertility, even in those women without obvious macroscopic anatomical pelvic abnormalities also have unexplained infertility. Generally, besides the well-known impairment of classically described oviduct cells caused by inflammatory diseases, such as the ciliated cells, fibroblasts and myofibroblasts, the involvement of the newly identified telocytes (TCs) in disease-affected oviduct tissues and potential pathophysiological roles in fertility problems remain unknown...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27793379/the-role-of-steroid-hormone-supplementation-in-non-assisted-reproductive-technology-treatments-for-unexplained-infertility
#18
REVIEW
Alexander M Quaas, Karl R Hansen
Fertility treatment strategies are evolving, with a more rapid transition to assisted reproductive technology (ART) treatments after unsuccessful non-ART treatments. This trend increases the potential importance of adjuvant treatments in non-ART cycles, such as steroid hormone supplementation. It has been established that success rates of ART treatments are increased with the use of luteal support with progesterone. In the setting of non-ART cycles, however, the evidence is less clear, and clinical practices vary widely between providers and clinics...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27785393/detection-of-mutations-in-the-cyp21a2-gene-genotype-phenotype-correlation-in-slovenian-couples-with-conceiving-problems
#19
Š Stangler Herodež, L Fijavž, B Zagradišnik, N Kokalj Vokač
The objective of this study was to compare the CYP 21A2 genetic profiles of couples with unexplained fertility problems (UFP) with genetic profiles of healthy controls (HCs). Furthermore, we analyzed associations between mutations in the CYP21A2 gene and various clinical and laboratory parameters. Allele-specific polymerase chain reaction (PCR) was used in 638 probands with UFP and 200 HCs. Statistic analysis with χ(2) was used to study the association of mutations with infertility. The effect of mutations on particular clinical and laboratory parameters was assessed with the analysis of variance (ANOVA) test...
December 1, 2015: Balkan Journal of Medical Genetics: BJMG
https://www.readbyqxmd.com/read/27769945/akt-activation-by-evodiae-fructus-extract-protects-ovary-against-4-vinylcyclohexene-diepoxide-induced-ovotoxicity
#20
Eun-Young Nam, Sun Ah Kim, Heejung Kim, Su-Hyun Kim, Jae-Hyun Han, Ju-Hee Lee, Dong-Il Kim
ETHNOPHARMACOLOGICAL RELEVANCE: Evodiae Fructus (EF) is the dried, unripe fruit of Evodia rutaecarpa Benth., and one of the main components of traditional herbal prescriptions issued for the treatment of sterility caused by irregular menstruation in Korea. However, scientific evidence regarding the efficacy and action mechanism of EF is lacking. AIM OF THE STUDY: In this study, the authors established an in vitro screening tool to identify promising new drug candidates in herbal medicines for the prevention and treatment of premature ovarian failure...
October 18, 2016: Journal of Ethnopharmacology
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