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Unexplained infertility

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https://www.readbyqxmd.com/read/29143242/comparing-reactive-oxygen-species-and-dna-fragmentation-in-semen-samples-of-unexplained-infertile-and-healthy-fertile-men
#1
Zahra Zandieh, Akram Vatannejad, Mahmood Doosti, Sara Zabihzadeh, Mahnaz Haddadi, Leila Bajelan, Batool Rashidi, Saeid Amanpour
BACKGROUND: Male factor infertility has increased to more than 40% during the last decade. About 30% of these couples are diagnosed with unexplained infertility. In fact, reactive oxygen species (ROS), especially superoxide anion (O2(-)·) and hydrogen peroxide (H2O2), play a crucial role in regulation of physiological and pathological processes in spermatozoa. Moreover, since the diagnosis of unexplained infertility just through semen analysis is a matter of much controversy; we aimed to evaluate the levels of ROS and sperm DNA fragmentation in the semen samples of unexplained infertile and fertile control couples...
November 15, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29142445/a-study-of-controlled-ovarian-stimulation-with-clomiphene-citrate-or-letrozole-in-combination-with-gonadotropins-and-iui-in-unexplained-infertility
#2
Madhusmita Hembram, Ratna Biswas, Anju Jain
Aim: To compare the effect of clomiphene citrate (CC) + human menopausal gonadotropin (hMG) with letrozole + hMG on size, number of follicles, endometrial thickness, serum levels of oestradiol and progesterone and pregnancy rate. Settings and Design: Non-randomised interventional study. Patients and Methods: A total number of 60 patients in the age group of 20-35 years with unexplained infertility were divided into two groups, 30 in each. Group A received CC + hMG and group B received letrozole + hMG...
July 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29141509/relative-morphokinetics-assessed-by-time-lapse-imaging-are-altered-in-embryos-from-patients-with-endometriosis
#3
Alexander Freis, Jens Erik Dietrich, Moritz Binder, Verena Holschbach, Thomas Strowitzki, Ariane Germeyer
INTRODUCTION: Time-lapse technology allows almost continuous noninvasive assessment of embryonic development. It was shown previously that relative kinetics defining cleavage synchronicity are better predictors of blastocyst quality than absolute time points. This study aims to compare relative kinetics in embryos from patients with and without endometriosis. METHODS: Time-lapse data were collected retrospectively from 596 patients undergoing infertility treatment for in vitro fertilization from January 2011 to July 2016...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/29141456/increased-serum-levels-of-mbdnf-in-women-with-minimal-and-mild-endometriosis-have-no-predictive-power-for-the-disease
#4
Alexandra Perricos, Kazem Ashjaei, Heinrich Husslein, Katharina Proestling, Lorenz Kuessel, Reinhard Obwegeser, Rene Wenzl, Iveta Yotova
The objective of our pilot clinical, prospective study was to determine the serum levels of mature brain-derived neurotrophic factor, in of women with endometriosis and controls and explore whether mature brain-derived neurotrophic factor is a potential biomarker for the disease. The patients were selected from the Endometriosis Marker Austria prospective cohort study conducted at the tertiary referral certified Endometriosis Center of the Medical University of Vienna. All women underwent laparoscopic surgery because there was a suspicion of endometriosis, or the women had pelvic pain, adnexal cysts, unexplained infertility, or uterine fibroids...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29135053/chronic-endometritis-in-patients-with-unexplained-infertility-prevalence-and-effects-of-antibiotic-treatment-on-spontaneous-conception
#5
Ettore Cicinelli, Maria Matteo, Giueseppe Trojano, Paola C Mitola, Raffaele Tinelli, Amerigo Vitagliano, Francesco M Crupano, Achiropita Lepera, Giuseppe Miragliotta, Leonardo Resta
PROBLEM: The correlations between chronic endometritis and unexplained infertility are unexplored. METHOD OF STUDY: We performed a retrospective study on consecutive patients referred to our hysteroscopy service due to unexplained infertility. All women underwent endometrial sampling with histological and cultural examinations. If chronic endometritis was diagnosed, patients received antibiotic therapy, and chronic endometritis resolution was subsequently ascertained by histological examination...
November 14, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29132967/unexplained-infertility-and-undiagnosed-celiac-disease-study-of-a-multiethnic-canadian-population
#6
Beth Gunn, Kellie E Murphy, Ellen M Greenblatt
OBJECTIVE: The aims of this study were to examine the prevalence of Celiac disease (CD) in Canadian women with unexplained infertility versus women with an identifiable cause of infertility and to assess the sensitivity of the point-of-care Biocard Celiac Test Kit versus standard serum serologic testing. METHODS: In this prospective cohort study, women aged 18 to 44 who were evaluated for infertility between February 2010 and May 2012 at a tertiary academic care fertility clinic in Toronto, ON, were invited to participate...
November 10, 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29126613/endometrial-bcl6-testing-for-the-prediction-of-in%C3%A2-vitro-fertilization-outcomes-a-cohort-study
#7
Laura D Almquist, Creighton E Likes, Benjamin Stone, Kaitlin R Brown, Ricardo Savaris, David A Forstein, Paul B Miller, Bruce A Lessey
OBJECTIVE: To evaluate endometrial BCL6 expression as a prognostic biomarker for IVF outcome in women with unexplained infertility (UI) before ET. DESIGN: Prospective cohort study. SETTING: University-associated infertility clinic. PATIENT(S): Women with UI for >1 year. INTERVENTION(S): We studied women with UI who underwent testing for endometrial BCL6, in an LH-timed midluteal phase biopsy and completed an IVF cycle and ET...
November 7, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/29117433/inter-and-intra-laboratory-standardization-of-tunel-assay-for-assessment-of-sperm-dna-fragmentation
#8
Sajal Gupta, Rakesh Sharma, Ashok Agarwal
The functional aspects of sperm activity such as sperm chromatin integrity and ability to fertilize cannot be characterized by routine semen parameters. Men with unexplained infertility and idiopathic infertility, as well as men with normozoospermic semen profiles, show high DNA fragmentation. Molecular anomalies in the sperm can be detected by a sperm DNA fragmentation (SDF) assay which can be used in adjunct to conventional semen analysis. While the sperm chromatin structure assay (SCSA) remains the "gold standard," the TUNEL assay using flow cytometry is becoming popular among the different tests that are currently available to measure sperm DNA fragmentation...
November 8, 2017: Current Protocols in Toxicology
https://www.readbyqxmd.com/read/29112778/clinical-application-of-hysteroscopic-hydrotubation-for-unexplained-infertility-in-the-mare
#9
Y Inoue, M Sekiguchi
BACKGROUND: Therapeutic techniques for oviductal obstruction in the mare are limited. Non-surgical and retrograde flushing may be an attractive alternative to current treatment methods for oviductal blockage. OBJECTIVES: To evaluate hysteroscopic selective hydrotubation as a treatment option for presumptive equine oviductal blockage. STUDY DESIGN: Retrospective case series. METHODS: Ten ml of saline was flushed through the oviducts in 28 standing sedated mares, which had reproductive histories of unexplained subfertility, by inserting a catheter into the uterotubal junction under endoscopic guidance...
November 7, 2017: Equine Veterinary Journal
https://www.readbyqxmd.com/read/29082207/a-strengths-weaknesses-opportunities-threats-swot-analysis-on-the-clinical-utility-of-sperm-dna-fragmentation-testing-in-specific-male-infertility-scenarios
#10
Sandro C Esteves, Ashok Agarwal, Chak-Lam Cho, Ahmad Majzoub
BACKGROUND: Sperm DNA fragmentation (SDF) is recognized as a leading cause of male infertility because it can impair the paternal genome through distinct pathophysiological mechanisms. Current evidence supports SDF as a major factor in the pathophysiology of several conditions, including varicocele, unexplained infertility, assisted reproductive technology failure, and environmental lifestyle factors, although the mechanisms involved have not been fully described yet. Measurement of the levels of DNA fragmentation in semen provides valuable information on the integrity of paternal chromatin and may guide therapeutic strategies...
September 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29082146/clinical-utility-of-sperm-dna-fragmentation-testing-concise-practice-recommendations
#11
EDITORIAL
Chak-Lam Cho, Ashok Agarwal, Ahmad Majzoub, Sandro C Esteves
Sperm DNA integrity is generally acknowledged as an essential component for human reproduction. While the negative impact of high sperm DNA fragmentation (SDF) on outcomes of natural pregnancy and assisted reproductive technology (ART) is well known, the clinical indication of SDF testing is less well defined. A recent review on clinical utility of SDF testing highlighted the different SDF assays and clinical indications of SDF testing. This concise practice recommendations aim at summarizing the evidence and presenting to the readers the essence of the clinical utility of SDF testing based on the currently existing evidence...
September 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29078018/cervical-mucus-removal-prior-to-intrauterine-insemination-a-randomized-trial
#12
Mohammad Ahmed Maher, Tarek Mohammad Sayyed, Nabih Elkhouly
OBJECTIVE: To detect if removing the cervical mucus before performing intrauterine insemination (IUI) could improve pregnancy outcomes in patients with unexplained infertility. DESIGN: Prospective randomized study. SETTING: An Egyptian University Hospital. POPULATION: Seven hundred fourteen couples with unexplained infertility who underwent intrauterine insemination (IUI) with or without cervical mucus removal. METHODS: Patients were randomly allocated using computer-generated numbers into cervical mucus removal (removed from both internal and external os) or a non-mucus removal groups...
October 27, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29063651/area-under-the-curve-of-temporal-estrogen-and-progesterone-measurements-during-assisted-reproductive-technology-which-hormone-is-the-main-determinant-of-cycle-outcome
#13
Enis Ozkaya, Tayfun Kutlu, Cigdem Abide Yayla, Semra Kayatas Eser, Ilhan Sanverdi, Belgin Devranoglu
AIM: Is there any relationship between estrogen and progesterone concentrations during assisted reproductive technology (ART)? Which hormone is the main determinant of impaired endometrial receptivity? METHODS: This study was conducted from July to December 2016 at the in vitro Fertilization/Intracytoplasmic Sperm Injection unit at Zeynep Kamil Women and Children's Health Training and Research Hospital. A total of 289 women who underwent ART were prospectively screened and areas under the curve of temporal estrogen (AUCEM) and progesterone measurements (AUCPM) were calculated for each participant...
October 24, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29063503/are-blastocyst-aneuploidy-rates-different-between-fertile-and-infertile-populations
#14
Jonathan D Kort, Rajiv C McCoy, Zach Demko, Ruth B Lathi
PURPOSE: This study aimed to determine if patients with infertility or recurrent pregnancy loss have higher rates of embryo aneuploidy than fertile controls. METHODS: This was a retrospective review of all pre-implantation genetic screening (PGS) cases processed by a single reference lab prior to March 2014 after a blastocyst biopsy. Cases were excluded if no indication for PGS was designated or patients were translocation carriers. The fertile control group consisted of patients undergoing IVF with PGS for sex selection only...
October 23, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29059580/characteristics-of-peripheral-blood-nk-and-nkt-like-cells-in-euthyroid-and-subclinical-hypothyroid-women-with-thyroid-autoimmunity-experiencing-reproductive-failure
#15
Eva Miko, Matyas Meggyes, Katalin Doba, Nelli Farkas, Barbara Bogar, Aliz Barakonyi, Laszlo Szereday, Julia Szekeres-Bartho, Emese Mezosi
Thyroid autoimmunity (TAI) appears to play a crucial role in female infertility, recurrent pregnancy loss and IVF failure. Thyroid autoantibodies against thyroid peroxidase and thyroglobulin have been shown to represent an independent risk factor for infertility and miscarriage. Moreover, thyroxin hormone administration reduces the risk of obstetrical complications in TAI positive women. The aim of our present study was to investigate the immunological background of female infertility and recurrent pregnancy loss in euthyroid and subclinical hypothyroid women with TAI focusing on innate immunity...
September 28, 2017: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/29026720/efficacy-of-embryo-transfer-on-day-2-versus-day-3-according-to-maternal-age-in-patients-with-normal-ovarian-response
#16
Jung-Woo Lee, Jeong-Ho Cha, Sun-Hee Shin, Yun-Jeong Kim, Seul-Ki Lee, Choon-Keun Park, Kyung-Ah Pak, Ji-Sung Yoon, Seo-Young Park
OBJECTIVE: Delaying embryo transfer (ET) enables us to select among the embryos available for transfer and is associated with positive effects on implantation and pregnancy outcomes. However, the optimal day for ET of human cleavage-stage embryos remains controversial. METHODS: A retrospective study of 3,124 in vitro fertilization/intracytoplasmic sperm injection cycles (2,440 patients) was conducted. We compared the effects of day 2 and 3 ET on rates of implantation and pregnancy outcomes between young maternal age (YMA; <38 years old, n=2,295) and old maternal age (OMA; ≥38 years old, n=829) patient groups...
September 2017: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/29021901/icsi-diagnostic-a-way-to-prevent-total-fertilization-failure-after-4-unsuccessful-iui
#17
Arnaud Larbuisson, Dominique Raick, Stephanie Demelenne, Annick Delvigne
BACKGROUND: The aim of this retrospective study is to investigate the relevance of dividing oocytes and using some for traditional in vitro fertilization (IVF) and others for intracytoplasmic sperm injection (ICSI) as of the first IVF cycle in patients with unexplained infertility who have undergone 4 intrauterine insemination (IUI) cycles which produced no pregnancies. METHODS: This retrospective study includes patients with unexplained infertility who have failed to become pregnant, after 4 IUI, despite normal semen parameters after sperm capacitation...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29020784/-screening-of-endometrial-nk-cells-in-selected-infertile-patients-first-part-methods-and-current-results
#18
Z Ulčová-Gallová, M Pešek, P Chaloupka, P Mukešnábl, M Haschová, P Losan, K Bibková, Z Mičanová, J Cibulka
INTRODUCTION: Generaly, natural killer cells (NK cells) are among the most important cells of our immune defense system. They are present in the blood, decidua but also in secretory endometrium. OBJECTIVE: We investigate an association between high density of NK cells CD56+ and NK cells CD16+ into blood and secretory endometrium in patients with up to now unexplained recurrent miscarriage. At the same time, we focused on diagnosis of antiphospholipid syndrome, congenital trombophilic factors, stress factor, and lenght of hormonal contraception before conception...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/29016666/novel-genes-and-mutations-in-patients-affected-by-recurrent-pregnancy-loss
#19
Paula Quintero-Ronderos, Eric Mercier, Michiko Fukuda, Ronald González, Carlos Fernando Suárez, Manuel Alfonso Patarroyo, Daniel Vaiman, Jean-Christophe Gris, Paul Laissue
Recurrent pregnancy loss is a frequently occurring human infertility-related disease affecting ~1% of women. It has been estimated that the cause remains unexplained in >50% cases which strongly suggests that genetic factors may contribute towards the phenotype. Concerning its molecular aetiology numerous studies have had limited success in identifying the disease's genetic causes. This might have been due to the fact that hundreds of genes are involved in each physiological step necessary for guaranteeing reproductive success in mammals...
2017: PloS One
https://www.readbyqxmd.com/read/28994562/can-unexplained-infertility-be-evaluated-by-a-new-immunological-four-biomarkers-panel-a-pilot-study
#20
Nicoletta Maxia, Stefano Uccella, Gabriele Ersettigh, Mario Fantuzzi, Massimiliano Manganini, Alessandro Scozzesi, Renato Colognato
BACKGROUD: Inflammation and oxidative stress are known to be triggering factors for a decrease of the pregnancy rate like maternal immunosuppression. Under these circumstances our study was performed to verify four immunological biomarkers (IMMUNOX Panel) in terms of incidence in a sine causa infertile population and the overall pregnancy rate when the Panel was showing some non-physiologic values. METHODS: Sera of 86 women affected by unexplained infertility were screened for the IMMUNOX panel of biomarkers composed by: TNF-α, Glycodelin (GLY), Total Oxidative Status (TOS) and Complement Activity Toxic Factor (CATF)...
October 9, 2017: Minerva Ginecologica
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