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Withaferin A AND NF-kB

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https://www.readbyqxmd.com/read/27209361/withania-somnifera-and-its-withanolides-attenuate-oxidative-and-inflammatory-responses-and-up-regulate-antioxidant-responses-in-bv-2-microglial-cells
#1
Grace Y Sun, Runting Li, Jiankun Cui, Mark Hannink, Zezong Gu, Kevin L Fritsche, Dennis B Lubahn, Agnes Simonyi
Withania somnifera (L.) Dunal, commonly known as Ashwagandha, has been used in Ayurvedic medicine for promoting health and quality of life. Recent clinical trials together with experimental studies indicated significant neuroprotective effects of Ashwagandha and its constituents. This study is aimed to investigate anti-inflammatory and anti-oxidative properties of this botanical and its two withanolide constituents, namely, Withaferin A and Withanolide A, using the murine immortalized BV-2 microglial cells...
September 2016: Neuromolecular Medicine
https://www.readbyqxmd.com/read/23969857/withaferin-a-a-proteasomal-inhibitor-promotes-healing-after-injury-and-exerts-anabolic-effect-on-osteoporotic-bone
#2
V Khedgikar, P Kushwaha, J Gautam, A Verma, B Changkija, A Kumar, S Sharma, G K Nagar, D Singh, P K Trivedi, N S Sangwan, P R Mishra, R Trivedi
Withania somnifera or Ashwagandha is a medicinal herb of Ayurveda. Though the extract and purified molecules, withanolides, from this plant have been shown to have different pharmacological activities, their effect on bone formation has not been studied. Here, we show that one of the withanolide, withaferin A (WFA) acts as a proteasomal inhibitor (PI) and binds to specific catalytic β subunit of the 20S proteasome. It exerts positive effect on osteoblast by increasing osteoblast proliferation and differentiation...
August 22, 2013: Cell Death & Disease
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