keyword
https://read.qxmd.com/read/37571393/underlying-mechanisms-of-brain-aging-and-neurodegenerative-diseases-as-potential-targets-for-preventive-or-therapeutic-strategies-using-phytochemicals
#1
REVIEW
Hamid Mostafavi Abdolmaleky, Jin-Rong Zhou
During aging, several tissues and biological systems undergo a progressive decline in function, leading to age-associated diseases such as neurodegenerative, inflammatory, metabolic, and cardiovascular diseases and cancer. In this review, we focus on the molecular underpinning of senescence and neurodegeneration related to age-associated brain diseases, in particular, Alzheimer's and Parkinson's diseases, along with introducing nutrients or phytochemicals that modulate age-associated molecular dysfunctions, potentially offering preventive or therapeutic benefits...
August 4, 2023: Nutrients
https://read.qxmd.com/read/37379799/inhibition-of-tumor-specific-angiogenesis-by-as1411-aptamer-functionalized-withaferin-a-loaded-pegylated-nanoliposomes-by-targeting-nucleolin
#2
JOURNAL ARTICLE
Prathapan Abeesh, Chandrasekaran Guruvayoorappan
Angiogenesis is a vital process for tumor growth and metastasis. Inhibition of angiogenesis is a promising strategy in cancer treatment. In this study, we analyzed the anti-angiogenic activity of AS1411 functionalized Withaferin A encapsulated PEGylated nanoliposomes (ALW) using both in vitro and in vivo models. AS1411 aptamer functionalized nanoliposomes are an efficient drug delivery system for carrying chemotherapeutic agents to target cancer cells, and Withaferin A (WA) is a steroidal lactone known for potent anti-angiogenic activity...
May 25, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/35745829/evaluation-of-the-cytotoxic-anti-inflammatory-and-immunomodulatory-effects-of-withaferin-a-wa-against-lipopolysaccharide-lps-induced-inflammation-in-immune-cells-derived-from-balb-c-mice
#3
JOURNAL ARTICLE
Abdullah M Alnuqaydan, Abdulmajeed Almutary, Gh Rasool Bhat, Tanveer Ahmad Mir, Shadil Ibrahim Wani, Mohd Younis Rather, Shabir Ahmad Mir, Bader Alshehri, Sulaiman Alnasser, Faten M Ali Zainy, Bilal Rah
(1) Background: Inflammation is one of the primary responses of the immune system and plays a key role in the pathophysiology of various diseases. Recent reports suggest that various phytochemicals exhibit promising anti-inflammatory and immunomodulation activities with relatively few undesirable effects, thus offering a viable option to deal with inflammation and associated diseases. The current study evaluates the anti-inflammatory and immunomodulatory effects of withaferin A (WA) in immune cells extracted from BALB/c mice...
June 13, 2022: Pharmaceutics
https://read.qxmd.com/read/35533610/withania-somnifera-a-magic-plant-targeting-multiple-pathways-in-cancer-related-inflammation
#4
REVIEW
Praveen Kumar, Rohit Sharma, Neha Garg
BACKGROUND: Deregulated inflammatory responses are known to play a pivotal role in cancer initiation and progression. Tumor microenvironment is associated with the presence of a diverse array of inflammatory reactions, which further help tumor growth, metastasis and drug resistance. Withania somnifera is known to curb proliferation of cancer cells and lower inflammatory responses. PURPOSE: In order to minimize the inflammation, cancer treatments often include immunomodulatory drugs...
May 2, 2022: Phytomedicine
https://read.qxmd.com/read/33182809/tackling-chronic-inflammation-with-withanolide-phytochemicals-a-withaferin-a-perspective
#5
REVIEW
Emilie Logie, Wim Vanden Berghe
Chronic inflammatory diseases are considered to be one of the biggest threats to human health. Most prescribed pharmaceutical drugs aiming to treat these diseases are characterized by side-effects and negatively affect therapy adherence. Finding alternative treatment strategies to tackle chronic inflammation has therefore been gaining interest over the last few decades. In this context, Withaferin A (WA), a natural bioactive compound isolated from Withania somnifera, has been identified as a promising anti-cancer and anti-inflammatory compound...
November 10, 2020: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/29479354/withaferin-a-associated-differential-regulation-of-inflammatory-cytokines
#6
JOURNAL ARTICLE
Seema Dubey, Hyunho Yoon, Mark Steven Cohen, Prakash Nagarkatti, Mitzi Nagarkatti, Dev Karan
A role of inflammation-associated cytokines/chemokines has been implicated in a wide variety of human diseases. Here, we investigated the regulation of inflammatory cytokines released by monocyte-derived THP-1 cells following treatment with the dietary agent withaferin A (WFA). Membrane-based cytokine array profiling of the culture supernatant from adenosine triphosphate-stimulated WFA-treated THP-1 cells showed differential regulation of multiple cytokines/chemokines. A selected group of cytokines/chemokines [interleukin-1 beta (IL-1β), CCL2/MCP-1, granulocyte-macrophage colony stimulating factor, PDGF-AA, PTX3, cystatin-3, relaxin-2, TNFRSF8/CD30, and ACRP30] was validated at the transcription level using qPCR...
2018: Frontiers in Immunology
https://read.qxmd.com/read/28573248/withaferin-a-induces-apoptosis-in-rat-c6-glioma-cells-through-regulating-nf-kb-nuclear-translocation-and-activation-of-caspase-cascade
#7
JOURNAL ARTICLE
Wei-Chen Hou, Xiao-Hui Miao, Lian-Jun Ma, Xiao-Xue Bai, Qun Liu, Lei Song
BACKGROUND: The demand for the chemopreventive drug from the plant source is increasing in recent times, owing to its various biological activities without any adverse effect. The intention of this current study was to examine the anti-glioma effect of Withaferin A (WFA) on C6 glioma cell line model. MATERIALS AND METHODS: C6 glioma cells were administrated with different concentration of WFA (50, 100, 200 and 500 μg/mL) and DMSO (control) group to examine its anti-proliferative, anti-inflammatory and pro-apoptotic activities...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://read.qxmd.com/read/27209361/withania-somnifera-and-its-withanolides-attenuate-oxidative-and-inflammatory-responses-and-up-regulate-antioxidant-responses-in-bv-2-microglial-cells
#8
JOURNAL ARTICLE
Grace Y Sun, Runting Li, Jiankun Cui, Mark Hannink, Zezong Gu, Kevin L Fritsche, Dennis B Lubahn, Agnes Simonyi
Withania somnifera (L.) Dunal, commonly known as Ashwagandha, has been used in Ayurvedic medicine for promoting health and quality of life. Recent clinical trials together with experimental studies indicated significant neuroprotective effects of Ashwagandha and its constituents. This study is aimed to investigate anti-inflammatory and anti-oxidative properties of this botanical and its two withanolide constituents, namely, Withaferin A and Withanolide A, using the murine immortalized BV-2 microglial cells...
September 2016: Neuromolecular Medicine
https://read.qxmd.com/read/23969857/withaferin-a-a-proteasomal-inhibitor-promotes-healing-after-injury-and-exerts-anabolic-effect-on-osteoporotic-bone
#9
JOURNAL ARTICLE
V Khedgikar, P Kushwaha, J Gautam, A Verma, B Changkija, A Kumar, S Sharma, G K Nagar, D Singh, P K Trivedi, N S Sangwan, P R Mishra, R Trivedi
Withania somnifera or Ashwagandha is a medicinal herb of Ayurveda. Though the extract and purified molecules, withanolides, from this plant have been shown to have different pharmacological activities, their effect on bone formation has not been studied. Here, we show that one of the withanolide, withaferin A (WFA) acts as a proteasomal inhibitor (PI) and binds to specific catalytic β subunit of the 20S proteasome. It exerts positive effect on osteoblast by increasing osteoblast proliferation and differentiation...
August 22, 2013: Cell Death & Disease
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