V Khedgikar, P Kushwaha, J Gautam, A Verma, B Changkija, A Kumar, S Sharma, G K Nagar, D Singh, P K Trivedi, N S Sangwan, P R Mishra, R Trivedi
Withania somnifera or Ashwagandha is a medicinal herb of Ayurveda. Though the extract and purified molecules, withanolides, from this plant have been shown to have different pharmacological activities, their effect on bone formation has not been studied. Here, we show that one of the withanolide, withaferin A (WFA) acts as a proteasomal inhibitor (PI) and binds to specific catalytic β subunit of the 20S proteasome. It exerts positive effect on osteoblast by increasing osteoblast proliferation and differentiation...
August 22, 2013: Cell Death & Disease