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nosocomial meningitis

Rodrigo Hasbun
Nosocomial meningitis can occur in association with central nervous system (CNS) devices such as cerebrospinal shunts or drains, intrathecal pumps, and deep brain stimulators and carry substantial morbidity and mortality. Diagnosing and treating these infections may be challenging to physicians as cerebrospinal fluid cultures may be negative due to previous antibiotic therapy and cerebrospinal abnormalities may be secondary to the primary neurosurgical issue that prompted the placement of the CNS device (e...
November 2016: Current Infectious Disease Reports
Sophie Reissier, Romain Masson, François Guérin, Gérald Viquesnel, Joëlle Petitjean-Lecherbonnier, Sabine Pereyre, Vincent Cattoir, Christophe Isnard
Meningitis due to Mycoplasma hominis in adults is rarely described, with only three cases having been reported to date. A case of fatal meningitis in a 39-year-old patient after a neurosurgical procedure for a subarachnoid haemorrhage is reported herein. Identification and treatment were significantly delayed because of the rarity of the aetiology and difficulty identifying this organism with the routinely used conventional methods, such as Gram staining and agar growth on standard agar plates. Clinical procedures and the treatment of 'culture-negative' central nervous system infections is a real challenge for clinical microbiologists and clinicians, and M...
July 2016: International Journal of Infectious Diseases: IJID
Susanna K P Lau, Wang-Ngai Chow, Chuen-Hing Foo, Shirly O T Curreem, George Chi-Shing Lo, Jade L L Teng, Jonathan H K Chen, Ricky H Y Ng, Alan K L Wu, Ingrid Y Y Cheung, Sandy K Y Chau, David C Lung, Rodney A Lee, Cindy W S Tse, Kitty S C Fung, Tak-Lun Que, Patrick C Y Woo
Unlike Elizabethkingia meningoseptica, the clinical importance of E. anophelis is poorly understood. We determined the clinical and molecular epidemiology of bacteremia caused by Elizabethkingia-like species from five regional hospitals in Hong Kong. Among 45 episodes of Elizabethkingia-like bacteremia, 21 were caused by Elizabethkingia, including 17 E. anophelis, three E. meningoseptica and one E. miricola; while 24 were caused by other diverse genera/species, as determined by 16S rRNA gene sequencing. Of the 17 cases of E...
2016: Scientific Reports
Zhiqi Li, Xing Wu, Jian Yu, Xuehai Wu, Zhuoying Du, Yirui Sun, Qiang Yuan, Jin Hu
BACKGROUND: Nosocomial meningitis and ventriculitis (MEN) are serious complications in neuro-critical care unit (NCCU) patients. Few data are available on the risk factors and mortality rates among NCCU patients with these disorders caused by multi-drug-resistant (MDR) pathogens. Our aim was to identify the risk factors for MEN caused by such pathogens and in-hospital deaths in critically ill neurologic patients and to evaluate the impact of empirical combination antibiotic therapy (ECAT) on the outcomes of these patients...
August 2016: Surgical Infections
Po-Yi Paul Su, Steve Miller, Rachel Lena Rutishauser, Jennifer Babik
No abstract text is available yet for this article.
August 2016: Infectious Diseases
Dahraoui Souhail, Belefquih Bouchra, Badia Belarj, Rar Laila, Frikh Mohammed, Oumarou Mamane Nassirou, Ibrahimi Azeddine, Charki Haimeur, Abdelhay Lemnouer, Mostafa Elouennass
Treatment of Acinetobacter baumannii meningitis is an important challenge due to the accumulation of resistance of this bacteria and low meningeal diffusion of several antimicrobial requiring use of an antimicrobial effective combination to eradicate these species. We report a case of Acinetobacter baumannii multidrug-resistant nosocomial meningitis which was successfully treated with intravenous and intrathecal colistin associated with rifampicin.
2016: Case Reports in Infectious Diseases
Ridhwi Mukerji, Radhika Kakarala, Susan Jane Smith, Halina G Kusz
Nursing home-associated infections and antibiotic resistant pathogens constitute common and serious problems in the geriatric population.Chryseobacterium indologenes, a non-motile Gram-negative rod, though widely distributed in nature, is an uncommon human pathogen. Typically thought of as an organism of low virulence, it may cause serious infections, particularly among the immunocompromised. The majority of reported cases are nosocomial, often associated with immunosuppression or indwelling catheters. It has been reported as the causative agent in bacteraemia, peritonitis, pneumonia, empyema, pyelonephritis, cystitis, meningitis and central venous catheter-associated infections...
2016: BMJ Case Reports
Marlys LeBras, Ivy Chow, Vincent H Mabasa, Mary H H Ensom
Due to increasing prevalence of intracranial device use and multidrug-resistant and nosocomial organisms, central nervous system (CNS) infections requiring treatment with intraventricular (IVT) aminoglycosides are becoming increasingly common. This article systematically reviews IVT aminoglycoside literature in adults and integrates available evidence to serve as a practical reference for clinicians. Medline (1946 to December 2015), Embase (1974 to December 2015), PubMed (1966 to December 2015), Google, and Google Scholar were searched using the term aminoglycoside combined individually with the terms IVT, meningitis, shunt infection, ventriculitis, and cerebral spinal fluid...
April 4, 2016: Neurocritical Care
Dong Liu, Zeng-Shan Liu, Pan Hu, Ling Cai, Bao-Quan Fu, Yan-Song Li, Shi-Ying Lu, Nan-Nan Liu, Xiao-Long Ma, Dan Chi, Jiang Chang, Yi-Ming Shui, Zhao-Hui Li, Waqas Ahmad, Yu Zhou, Hong-Lin Ren
Acinetobacter baumannii is a Gram-negative bacillus that causes nosocomial infections, such as bacteremia, pneumonia, and meningitis and urinary tract and wound infections. In the present study, the surface antigen protein 1 (SurA1) gene of A. baumannii strain CCGGD201101 was identified, cloned and expressed, and then its roles in fitness and virulence were investigated. Virulence was observed in the human lung cancer cell lines A549 and HEp-2 at one week after treatment with recombinant SurA1. One isogenic SurA1 knock-out strain, GR0015, which was derived from the A...
April 15, 2016: Veterinary Microbiology
Sarah Tubiana, Xavier Duval, François Alla, Christine Selton-Suty, Pierre Tattevin, François Delahaye, Lionel Piroth, Catherine Chirouze, Jean-Philippe Lavigne, Marie-Line Erpelding, Bruno Hoen, François Vandenesch, Bernard Iung, Vincent Le Moing
OBJECTIVES: To develop and validate a prediction score, to quantify, within 48 h of Staphylococcus aureus bacteremia (SAB) diagnosis, the risk of IE, and therefore determine priority for urgent echocardiography. METHODS: Consecutive adult patients with SAB in 8 French university hospitals between 2009 and 2011 were prospectively enrolled and followed-up 3 months. A predictive model was developed and internally validated using bootstrap procedures. RESULTS: Among the 2008 patients enrolled, 221 (11...
May 2016: Journal of Infection
Shunlan Ni, Shanshan Li, Naibin Yang, Sainan Zhang, Danping Hu, Qian Li, Mingqin Lu
BACKGROUND: Acinetobacter baumannii (A. baumannii), a gram-negative bacterium, has now become an important hospital pathogen, which causes various serious nosocomial infections worldwide. Bacterial meningitis is a common complication after neurosurgical operation, and the percentage of A. baumannii meningitis is growing, especially the one resisting multiple drugs. METHOD: We retrospectively reviewed the cases with postoperative A. baumannii meningitis (PABM) in the First Affiliated Hospital of Wenzhou Medical University from January 2013 to October 2014...
2015: International Journal of Clinical and Experimental Medicine
Lisa Hayes, Prashant Malhotra
INTRODUCTION: Central nervous system (CNS) infections can have various presentations including Cerebrovascular accidents (CVA) which may go unrecognized as a presentation of infection. We describe three cases of different CNS infections complicated by CVA. PRESENTATION: Case 1 describes a 27-year-old man, presenting with symptoms consistent with a transient ischemic attack found to have racemose neurocysticercosis. Case 2 describes a 55-year-old man with low grade fevers for 4 weeks accompanied by visual and gait disturbances and delayed speech diagnosed with multiple small left thalamocapsular and superior cerebellar infarcts secondary to cryptococcal meningitis...
2014: IDCases
George Fotakopoulos, Demosthenes Makris, Maria Chatzi, Eleni Tsimitrea, Epaminondas Zakynthinos, Kostas Fountas
BACKGROUND: The aim of this work is to evaluate the outcome of patients treated with intrathecal colistin for meningitis/ventriculitis. METHODS: This retrospective case series study included patients presenting with nosocomial meningitis/ventriculitis following neurosurgical interventions and having intravenous (IVC group) or intravenous and intrathecal/intraventricular colistin (ITC group) treatment between 2006 and 2014. RESULTS: Thirty-four patients presented nosocomial meningitis/ventriculitis; 11 (32...
March 2016: Acta Neurochirurgica
Luis A Mora Mora, Micke E de Arco Espinosa, Javier Plumet, Federico Micheli
Acute bacterial meningitis has a global mortality rate of 135000 cases per year. In Argentina over the last 12 years, the annual incidence rate has been 5.5/100 000. About 20% of patients present neurological sequelae, which are more common in patients aged 60 or older. Our objective here is to determine the clinical characteristics, the most common causes and to measure evolution in patients over 60 years old diagnosed with meningitis and treated at the Hospital de Clinicas José de San Martín. This is a retrospective study based on a review of medical records from 2003 to 2013 that takes into account patients older than 60 who were diagnosed with acute bacterial meningitis acquired in the community by a microbiological diagnosis of CSF or those included due to a high suspicion of bacterial meningitis (pleocitosis > 2000 cells/mm3, proteins > 220 mg/dl, glycorrhachia < 34 mg/dl, glycorrhachia/glucose index < 0...
2015: Medicina
Izeta Softić, Husref Tahirović, Mensuda Hasanhodžić
OBJECTIVE: The aim of the study was to determine the epidemiological characteristics of bacterial meningitis observed in neonates born in the Department of Gynaecology and Obstetrics, University Clinical Centre Tuzla, Bosnia and Herzegovina, admitted to Intensive care unit (NICU) or readmitted, because of suspected infection, after discharge from the nursery. SUBJECTS AND METHODS: This study was carried out from July 1, 2012 to June 30, 2013. During this period 4136 neonates were born...
2015: Acta Medica Academica
N V Kurdyumova, G V Danilov, O N Ershova, I A Savin, E Yu Sokolova, I A Aleksandrova, M A Shifrin
OBJECTIVE: To determine the incidence rate and risk factors of nosocomial meningitis in patients with complicated postoperative period. MATERIAL AND METHODS: We report the results of prospective observation of the course of bacterial meningitis in patients with complicated postoperative period at neurosurgical intensive care unit in 2010-2014. RESULTS: Nosocomial meningitis (NM) developed in 146 patients, which accounted for 12.6±1.0% (CI, 10...
2015: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Kim-Hung Huynh, Myoung-ki Hong, Clarice Lee, Huyen-Thi Tran, Sang Hee Lee, Yeh-Jin Ahn, Sun-Shin Cha, Lin-Woo Kang
Acinetobacter baumannii, which is emerging as a multidrug-resistant nosocomial pathogen, causes a number of diseases, including pneumonia, bacteremia, meningitis, and skin infections. With ATP hydrolysis, the D-alanine-D-alanine ligase (DDL) catalyzes the synthesis of D-alanyl-D-alanine, which is an essential component of bacterial peptidoglycan. In this study, we determined the crystal structure of DDL from A. baumannii (AbDDL) at a resolution of 2.2 Å. The asymmetric unit contained six protomers of AbDDL...
November 2015: Journal of Microbiology / the Microbiological Society of Korea
Aldukali Alkeskas, Pauline Ogrodzki, Mohamed Saad, Naqash Masood, Nasreddin R Rhoma, Karen Moore, Audrey Farbos, Konrad Paszkiewicz, Stephen Forsythe
BACKGROUND: The most common cause of Gram-negative bacterial neonatal meningitis is E. coli K1. It has a mortality rate of 10-15 %, and neurological sequelae in 30-50 % of cases. Infections can be attributable to nosocomial sources, however the pre-colonisation of enteral feeding tubes has not been considered as a specific risk factor. METHODS: Thirty E. coli strains, which had been isolated in an earlier study, from the residual lumen liquid and biofilms of neonatal nasogastric feeding tubes were genotyped using pulsed-field gel electrophoresis, and 7-loci multilocus sequence typing...
2015: BMC Infectious Diseases
Abdel Chahbouni, Frank Am van den Dungen, René M Vos, Jeroen Cg den Burger, Amo Sinjewel, Abraham J Wilhelm, Agnes I Veldkamp, Eleanor L Swart, Mirjam M van Weissenbruch
BACKGROUND: An UPLC-MS detection method for the quantification of amikacin, flucloxacillin, meropenem, penicillin G and vancomycin was developed and validated. RESULTS: The calibration curves were found to be linear from 0.47 to 50 mg/l for amikacin, 1.28 to 135 mg/l for flucloxacillin, 0.75 to 80 mg/l for meropenem, 0.38 to 80 mg/l for penicillin G and 0.73 to 80 mg/l for vancomycin. Between- and within-run accuracy was ranged between 85 and 115%. Between and within imprecision expressed as CV was within 15%...
September 29, 2015: Bioanalysis
Amir Ramezani, Katarina Nägga, Oskar Hansson, Johanna Lönn, Johanna Sjöwall, Fateme Katoozian, Sepahdar Mansouri, Fariba Nayeri
BACKGROUND: Due to anatomical restrictions, the inflammatory response to intracerebral bacterial infections exposes swollen brain tissues to pressure and ischemia, resulting in life-threatening damage. Rapid diagnosis and immediate empirical antibiotic therapy is highly important. However, diagnosing meningitis in patients after neurosurgery is complicated, due to brain tissue damage and changes in cerebrospinal fluid (CSF) caused by surgery. Hepatocyte growth factor (HGF) is a local, acute-phase protein with healing properties...
2015: Fluids and Barriers of the CNS
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