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https://www.readbyqxmd.com/read/29028374/recognizing-workplace-factors-contributing-to-interstitial-lung-disease
#1
Philip Harber
No abstract text is available yet for this article.
October 15, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29024492/experimental-infection-of-clade-1-1-2-h5n1-clade-2-3-2-1c-h5n1-and-clade-2-3-4-4-h5n6-highly-pathogenic-avian-influenza-viruses-in-dogs
#2
K S Lyoo, W Na, L V Phan, S W Yoon, M Yeom, D Song, D G Jeong
Since the emergence of highly pathogenic avian influenza (HPAI) H5N1 in Asia, the haemagglutinin (HA) gene of this virus lineage has continued to evolve in avian populations, and H5N1 lineage viruses now circulate concurrently worldwide. Dogs may act as an intermediate host, increasing the potential for zoonotic transmission of influenza viruses. Virus transmission and pathologic changes in HPAI clade 1.1.2 (H5N1)-, 2.3.2.1c (H5N1)- and 2.3.4.4 (H5N6)-infected dogs were investigated. Mild respiratory signs and antibody response were shown in dogs intranasally infected with the viruses...
October 11, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29023302/complete-resolution-of-lymphoid-interstitial-pneumonia-in-a-patient-with-juvenile-myelomonocytic-leukemia-treated-with-allogeneic-bone-marrow-transplant-killing-2-birds-with-1-stone
#3
Anant Vatsayan, Ravi Talati, Kristen Nagle, Linda Cabral, Sloane Cammock, Amy Dimarino, Rachel Egler, Shahrazad Saab, Jignesh Dalal
Lymphoid interstitial pneumonia (LIP) is a rare disease characterized by benign reactive polyclonal proliferation of bronchus-associated lymphoid tissue after exposure to inhaled or circulating antigen(s), leading to a disease symptomatology similar to idiopathic interstitial pneumonia. Its association with diseases that are caused due to immune dysregulation (autoimmune diseases, congenital/acquired immunodeficiency, and allogeneic bone marrow transplant) and response to immunomodulatory/suppressive medications suggests an immunologic pathophysiology...
October 11, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29019755/interstitial-lung-disease-in-children-made-easier%C3%A2-well-almost
#4
Thomas R Semple, Michael T Ashworth, Catherine M Owens
Interstitial lung disease (ILD) in pediatric patients is different from that in adults, with a vast array of pathologic conditions unique to childhood, varied modes of presentation, and a different range of radiologic appearances. Although rare, childhood ILD (chILD) is associated with significant morbidity and mortality, most notably in conditions of disordered surfactant function, with respiratory failure in 100% of neonates with surfactant protein B dysfunction and 100% mortality without lung transplantation...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29019592/the-influence-of-allopurinol-and-post-conditioning-on-lung-injuries-induced-by-lower-limb-ischemia-and-reperfusion-in-wistar-rats
#5
Hugo Genki Kagawa Akahane, Ricardo Zanetti Gomes, Katia Sabrina Paludo, Filipe Linhares, Luana Lopes
PURPOSE: To analyze the effects of allopurinol and of post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion. METHODS: Thirty rats were used. They were divided in 5 groups: (1) group A: abdominal aortic dissection only, (2) group B: ischemia and reperfusion, (3) group C: administered allopurinol (100mg/Kg) a few hours before procedure, (4) group D: post-conditioned and (5) group E: administered allopurinol and post-conditioned. With the exception of group A, all groups were submitted to infrarenal aortic ischemia for 2 hours, and reperfusion for 72 hours...
September 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29018976/capillary-loss-on-nailfold-capillary-microscopy-is-associated-with-mortality-in-systemic-sclerosis
#6
Thais Rohde Pavan, Markus Bredemeier, Vanessa Hax, Karina Gatz Capobianco, Rafael da Silva Mendonça Chakr, Ricardo Machado Xavier
The objective of this study is to test the association of the severity of nailfold capillaroscopy (NFC) abnormalities with mortality in systemic sclerosis (SSc). One hundred and seventy SSc patients underwent an extensive evaluation (including high-resolution computed tomography, pulmonary function tests, and Doppler echocardiography) at baseline following a standard protocol. Capillary loss on NFC was evaluated using the avascular score (AS, ranging from 0 to 3), and the mean number of ectasias, megacapillaries, and hemorrhages per finger was also recorded...
October 10, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29018526/design-of-the-pf-ild-trial-a-double-blind-randomised-placebo-controlled-phase-iii-trial-of-nintedanib-in-patients-with-progressive-fibrosing-interstitial-lung-disease
#7
Kevin R Flaherty, Kevin K Brown, Athol U Wells, Emmanuelle Clerisme-Beaty, Harold R Collard, Vincent Cottin, Anand Devaraj, Yoshikazu Inoue, Florence Le Maulf, Luca Richeldi, Hendrik Schmidt, Simon Walsh, William Mezzanotte, Rozsa Schlenker-Herceg
600 patients aged ≥18 years will be randomised in a 1:1 ratio to nintedanib or placebo. Patients with diagnosis of IPF will be excluded. The study population will be enriched with two-thirds having a usual interstitial pneumonia-like pattern on HRCT. The primary endpoint is the annual rate of decline in forced vital capacity over 52 weeks. The main secondary endpoints are the absolute change from baseline in King's Brief Interstitial Lung Disease Questionnaire total score, time to first acute interstitial lung disease exacerbation or death and time to all-cause mortality over 52 weeks...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/29017512/metastatic-pathway-and-the-microvascular-and-physicochemical-microenvironments-of-human-melanoma-xenografts
#8
Ruixia Huang, Lise Mari K Andersen, Einar K Rofstad
BACKGROUND: Malignant melanoma of the skin can metastasize through blood vessels and lymphatics. The primary tumor develops a vascular microenvironment characterized by abnormal blood vessels and lymphatics and a physicochemical microenvironment characterized by low oxygen tension, regions with hypoxic tissue, and high interstitial fluid pressure (IFP). This study aimed at identifying relationships between the metastatic route of melanomas and characteristic features of the microvascular and physicochemical microenvironments of the primary tumor...
October 10, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29017478/effectiveness-of-pulmonary-rehabilitation-in-patients-with-interstitial-lung-disease-of-different-etiology-a-multicenter-prospective-study
#9
Roberto Tonelli, Elisabetta Cocconcelli, Barbara Lanini, Isabella Romagnoli, Fabio Florini, Ivana Castaniere, Dario Andrisani, Stefania Cerri, Fabrizio Luppi, Riccardo Fantini, Alessandro Marchioni, Bianca Beghè, Francesco Gigliotti, Enrico M Clini
BACKGROUND: Recent evidences show that Pulmonary Rehabilitation (PR) is effective in patients with Interstitial Lung Disease (ILD). It is still unclear whether disease severity and/or etiology might impact on the reported benefits. We designed this prospective study 1) to confirm the efficacy of rehabilitation in a population of patients with ILDs and 2) to investigate whether baseline exercise capacity, disease severity or ILD etiology might affect outcomes. METHODS: Forty-one patients (IPF 63%, age 66...
October 10, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28994016/cardiopulmonary-manifestations-of-collagen-vascular-diseases
#10
REVIEW
Hamza Jawad, Sebastian R McWilliams, Sanjeev Bhalla
PURPOSE OF REVIEW: The study aimed to illustrate the cardiopulmonary findings of the following collagen vascular diseases on cross-sectional imaging: rheumatoid arthritis, scleroderma (progressive systemic sclerosis), systemic lupus erythematosus, the inflammatory myopathies (polymyositis/dermatomyositis), and Sjögren's syndrome. RECENT FINDINGS: Although collagen vascular diseases can affect any part of the body, interstitial lung disease and pulmonary hypertension are the two most important cardiopulmonary complications and are responsible for the majority of morbidity and mortality in this patient population...
October 9, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28993806/genetics-in-idiopathic-pulmonary-fibrosis-pathogenesis-prognosis-and-treatment
#11
REVIEW
Amarpreet Kaur, Susan K Mathai, David A Schwartz
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial pneumonia (IIP), is characterized by irreversible scarring of the lung parenchyma and progressive decline in lung function leading to eventual respiratory failure. The prognosis of IPF is poor with a median survival of 3-5 years after diagnosis and no curative medical therapies. Although the pathogenesis of IPF is not well understood, there is a growing body of evidence that genetic factors contribute to disease risk. Recent studies have identified common and rare genetic variants associated with both sporadic and familial forms of pulmonary fibrosis, with at least one-third of the risk for developing fibrotic IIP explained by common genetic variants...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28993026/effects-of-physical-characteristics-of-carbon-black-on-metabolic-regulation-in-mice
#12
Hsiao-Chi Chuang, Ta-Chih Hsiao, Chii-Hong Lee, Justin Chun-Te Lin, Kai-Jen Chuang, Po-Hao Feng, Tsun-Jen Cheng
Potential adverse effects of human exposure to carbon black (CB) have been reported, but limited knowledge regarding CB-regulated metabolism is currently available. To evaluate how physical parameters of CB influence metabolism, we investigated CB and diesel exhaust particles (DEPs) and attempted to relate various physical parameters, including the hydrodynamic diameter, zeta potential, and particle number concentrations, to lung energy metabolism in female BALB/c mice. A body weight increase was arrested by 3 months of exposure to CB of smaller-size fractions, which was negatively correlated with pyruvate in plasma...
October 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28992668/-spontaneous-remission-of-everolimus-induced-interstitial-lung-disease-in-metastatic-renal-cell-carcinoma-an-autopsy-case-report
#13
Masayuki Kurokawa, Sei Naito, Osamu Ichiyanagi, Takanobu Kabasawa, Yuta Kurota, Toshihiko Sakurai, Hayato Nishida, Hisashi Kawazoe, Tomoyuki Kato, Akira Nagaoka, Mitsunori Yamakawa, Norihiko Tsuchiya
Interstitial lung disease (ILD) is a common side effect of the mechanistic target of rapamycin inhibitor everolimus. Most cases of everolimus-induced ILD are mild and reversible. As per guidelines, even if Common Terminology Criteria for Adverse Events grade 1 or 2 everolimus-induced ILD occurs, either continuation of everolimus without dose reduction or readministration at a low dose is possible. However, the pathophysiology of everolimus-induced ILD is unknown. We present a case of everolimus-induced ILD with spontaneous remission during treatment in a patient with metastatic renal cell carcinoma...
September 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28992174/interstitial-lung-disease-points-to-consider-for-clinical-trials-in-systemic-sclerosis
#14
REVIEW
Dinesh Khanna, James Seibold, Jonathan Goldin, Donald P Tashkin, Daniel E Furst, Athol Wells
Interstitial lung disease causes major morbidity and mortality in patients with systemic sclerosis (SSc-ILD). Large randomized clinical trials in SSc-ILD have provided important information regarding the feasibility, reliability and validity of outcome measures. Forced vital capacity percentage predicted should be considered as a primary outcome measure, with inclusion of appropriate radiological and patient-reported measures. We provide practical recommendations for trial design in SSc-ILD.
September 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28991646/epidemiology-of-lung-disease-in-older-persons
#15
REVIEW
Carlos A Vaz Fragoso
Older persons frequently report respiratory risk factors and symptoms and have a high prevalence of symptomatic lung disease, most commonly obstructive airway disease, interstitial lung disease, and lung cancer. Notably, coexisting nonrespiratory risk factors are also prevalent and may misidentify or modify respiratory diagnoses and their clinical course.
November 2017: Clinics in Geriatric Medicine
https://www.readbyqxmd.com/read/28990899/cytomegalovirus-pneumonia-in-an-immunosuppressed-child-mimicking-interstitial-lung-disease
#16
Esra Karakuş, Güzin Cinel, Saliha Kanık Yüksek, Belgin Gülhan
No abstract text is available yet for this article.
June 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28983955/associations-between-anti-melanoma-differentiation-associated-gene-5-antibody-and-demographics-clinical-characteristics-and-laboratory-results-of-patients-with-dermatomyositis-a-systematic-meta-analysis
#17
Ju Li, Yan Liu, Yongsheng Li, Fang Li, Kai Wang, Wenyou Pan, Deqian Meng
Anti-melanoma differentiation-associated gene 5 (MDA5) antibody is a specific biomarker in patients with dermatomyositis (DM). Results from several studies that examined the relationship between anti-MDA5 antibody and the demographics, clinical characteristics and laboratory results of DM patients have been conflicting. The purpose of this study was to identify the relationship, if any, of anti-MDA5 antibody with demographics, clinical characteristics and laboratory results of DM patients. PubMed, Web of Science, Embase and the Cochrane Library databases were searched for studies without language restrictions conducted before 16 March 2017...
October 6, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28981359/dendriform-pulmonary-ossification-in-the-absence-of-usual-interstitial-pneumonia-ct-features-and-possible-association-with-recurrent-acid-aspiration
#18
James F Gruden, Daniel B Green, Alan C Legasto, Eric A Jensen, Prasad M Panse
OBJECTIVE: Dendriform pulmonary ossification (DPO) is a rare lung disease in which mature bone is present in the peripheral interstitium of the lung. It typically occurs in patients with usual interstitial pneumonia (UIP). We assessed patients with CT findings of DPO without UIP to determine possible causative factors and to assess the clinical and CT course. We hypothesized that DPO without UIP would be a unique entity. MATERIALS AND METHODS: We retrospectively reviewed CT reports for the word "ossification...
October 5, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28980912/influence-of-antibody-profile-in-clinical-features-and-prognosis-in-a-cohort-of-spanish-patients-with-systemic-sclerosis
#19
Nerea Iniesta Arandia, Carmen Pilar Simeón-Aznar, Alfredo Guillén Del Castillo, Dolores Colunga Argüelles, Manuel Rubio-Rivas, Luis Trapiella Martínez, Francisco José García Hernández, Luis Sáez Comet, María Victoria Egurbide Arberas, Norberto Ortego-Centeno, Mayka Freire, Begoña Marí Alfonso, José Antonio Vargas Hitos, Juan José Ríos Blanco, José Antonio Todolí Parra, Monica Rodríguez-Carballeira, Adela Marín Ballvé, Antonio Javier Chamorro Fernández, Xavier Pla Salas, Ana Belen Madroñero Vuelta, Manuel Ruiz Muñoz, Vicent Fonollosa Pla, Gerard Espinosa
OBJECTIVES: To assess the clinical manifestations and prognosis of Spanish patients with systemic sclerosis (SSc) according to their immunological profile. METHODS: From the Spanish Scleroderma Study Group or RESCLE (Registro de ESCLErodermia as Spanish nomenclature) Registry we selected those patients in which anti-centromere (ACA), anti-topoisomerase I (ATA), and anti-RNA polymerase III (ARA) antibodies had been determined, and a single positivity for each SSc specific antibody was detected...
September 21, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28980905/clinical-and-epidemiological-differences-between-men-and-women-with-systemic-sclerosis-a-study-in-a-spanish-systemic-sclerosis-cohort-and-literature-review
#20
REVIEW
Mayka Freire, Alberto Rivera, Bernardo Sopeña, Carles Tolosa Vilella, Alfredo Guillén-Del Castillo, Dolores Colunga Argüelles, Jose Luis Callejas Rubio, Manuel Rubio Rivas, Luis Trapiella Martínez, Jose Antonio Todolí Parra, Mónica Rodríguez Carballeira, Nerea Iniesta Arandia, Francisco José García Hernández, María Victoria Egurbide Arberas, Luis Sáez Comet, Jose Antonio Vargas Hitos, Juan José Ríos Blanco, Adela Marín Ballvé, Xavier Pla Salas, Ana Belén Madroñero Vuelta, Manuel Ruiz Muñoz, Vicent Fonollosa Pla, Carmen Pilar Simeón Aznar
OBJECTIVES: The low overall prevalence of systemic sclerosis (SSc) and the low proportion of male patients have resulted in a scarcity of studies assessing sex differences in Ssc patients, and contradictory results have often been show among those studies that have been performed. METHODS: A prospective study was conducted with the Spanish RESCLE register to analyse the influence of gender on survival of SSc patients. RESULTS: In total, 1506 SSc patients (1341 women, 165 men) were recruited from 21 centres...
September 18, 2017: Clinical and Experimental Rheumatology
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