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Lipogems

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https://www.readbyqxmd.com/read/27547712/adipose-tissue-and-mesenchymal-stem-cells-state-of-the-art-and-lipogems%C3%A2-technology-development
#1
Carlo Tremolada, Valeria Colombo, Carlo Ventura
In the past few years, interest in adipose tissue as an ideal source of mesenchymal stem cells (MSCs) has increased. These cells are multipotent and may differentiate in vitro into several cellular lineages, such as adipocytes, chondrocytes, osteoblasts, and myoblasts. In addition, they secrete many bioactive molecules and thus are considered "mini-drugstores." MSCs are being used increasingly for many clinical applications, such as orthopedic, plastic, and reconstructive surgery. Adipose-derived MSCs are routinely obtained enzymatically from fat lipoaspirate as SVF and/or may undergo prolonged ex vivo expansion, with significant senescence and a decrease in multipotency, leading to unsatisfactory clinical results...
2016: Current Stem Cell Reports
https://www.readbyqxmd.com/read/27547374/angiogenic-and-anti-inflammatory-properties-of-micro-fragmented-fat-tissue-and-its-derived-mesenchymal-stromal-cells
#2
Valentina Ceserani, Anna Ferri, Angiola Berenzi, Anna Benetti, Emilio Ciusani, Luisa Pascucci, Cinzia Bazzucchi, Valentina Coccè, Arianna Bonomi, Augusto Pessina, Erica Ghezzi, Offer Zeira, Piero Ceccarelli, Silvia Versari, Carlo Tremolada, Giulio Alessandri
BACKGROUND: Adipose-derived mesenchymal stromal cells (Ad-MSCs) are a promising tool for advanced cell-based therapies. They are routinely obtained enzymatically from fat lipoaspirate (LP) as SVF, and may undergo prolonged ex vivo expansion, with significant senescence and decline in multipotency. Besides, these techniques have complex regulatory issues, thus incurring in the compelling requirements of GMP guidelines. Hence, availability of a minimally manipulated, autologous adipose tissue would have remarkable biomedical and clinical relevance...
2016: Vascular Cell
https://www.readbyqxmd.com/read/27236668/mesenchymal-stem-cells-in-lipogems-a-reverse-story-from-clinical-practice-to-basic-science
#3
Carlo Tremolada, Camillo Ricordi, Arnold I Caplan, Carlo Ventura
The idea that basic science should be the starting point for modern clinical approaches has been consolidated over the years, and emerged as the cornerstone of Molecular Medicine. Nevertheless, there is increasing concern over the low efficiency and inherent costs related to the translation of achievements from the bench to the bedside. These burdens are also perceived with respect to the effectiveness of translating basic discoveries in stem cell biology to the newly developing field of advanced cell therapy or Regenerative Medicine...
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27217090/the-adipose-mesenchymal-stem-cell-secretome-inhibits-inflammatory-responses-of-microglia-evidence-for-an-involvement-of-sphingosine-1-phosphate-signalling
#4
Giovanni Marfia, Stefania Elena Navone, Loubna Abdel Hadi, Moira Paroni, Valeria Berno, Matteo Beretta, Roberta Gualtierotti, Francesca Ingegnoli, Vincenzo Levi, Monica Miozzo, Jens Geginat, Lorenzo Fassina, Paolo Rampini, Carlo Tremolada, Laura Riboni, Rolando Campanella
Central nervous system (CNS) inflammation is primarily driven by microglial cells which secrete proinflammatory cytokines and undergo proliferation upon activation, as it occurs in neurodegenerative diseases. Uncontrolled or prolonged CNS inflammation is potentially harmful and can result in cellular damage. Recently, many studies have focused on human adipose tissue as an attractive source of cytokines with immunosuppressive properties that potentially modulate inflammation. Our study aimed to evaluate if different methods of human tissue collection could affect adipose mesenchymal stem cell (ADSC)-derived cytokine secretion and investigate the effects of ADSC secretome in modulating microglia activation and the possible implication of sphingosine-1-phosphate (S1P) in these effects...
July 15, 2016: Stem Cells and Development
https://www.readbyqxmd.com/read/27057170/lipogems-product-treatment-increases-the-proliferation-rate-of-human-tendon-stem-cells-without-affecting-their-stemness-and-differentiation-capability
#5
Pietro Randelli, Alessandra Menon, Vincenza Ragone, Pasquale Creo, Sonia Bergante, Filippo Randelli, Laura De Girolamo, Umberto Alfieri Montrasio, Giuseppe Banfi, Paolo Cabitza, Guido Tettamanti, Luigi Anastasia
Increasing the success rate of rotator cuff healing remains tremendous challenge. Among many approaches, the possibility of activating resident stem cells in situ, without the need to isolate them from biopsies, could represent valuable therapeutic strategy. Along this line, it has been recently demonstrated that lipoaspirate product, Lipogems, contains and produces growth-factors that may activate resident stem cells. In this study, human tendon stem cells (hTSCs) from the rotator cuff were cocultured in a transwell system with the Lipogems lipoaspirate product and compared to control untreated cells in terms of cell proliferation, morphology, stem cell marker and VEGF expression, and differentiation and migration capabilities...
2016: Stem Cells International
https://www.readbyqxmd.com/read/26601557/transnasal-endoscopic-microfractured-fat-injection-in-glottic-insufficiency
#6
A M Saibene, C Pipolo, R Lorusso, S M Portaleone, G Felisati
OBJECTIVE: We evaluated a novel treatment for glottic insufficiency involving the injection of autologous material with direct glottic visualisation in an outpatient setting. METHODS: Three patients with vocal cord palsy underwent laryngoplasty under local anaesthesia using only a flexible endoscope with a working canal for Microfractured Fat Fibre-endoscopic Injection (MFFI). Adipose tissue was processed using the Lipogems device, which allows optimal purity, fluidity, and mesenchymal stem cell content in the resultant emulsion...
2015: B-ENT
https://www.readbyqxmd.com/read/26240640/intersphincteric-anal-lipofilling-with-micro-fragmented-fat-tissue-for-the-treatment-of-faecal-incontinence-preliminary-results-of-three-patients
#7
Giovanni Cestaro, Michele De Rosa, Salvatore Massa, Bruno Amato, Maurizio Gentile
Faecal incontinence is a very debilitating problem. Many techniques have been proposed to treat this condition, with controversial results. Autologous transplant of fat tissue is an established procedure used for the repair of tissue damage, and recent studies revealed the potentiality of tissue regeneration by human adipose-derived stem cells. We treated this condition with the injection, in the intersphincteric anal groove, of lipoaspirate processed by an innovative technology (Lipogems). The aim of the study was to evaluate the efficacy of Lipogems injection for the treatment of faecal incontinence...
July 2015: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/24044359/radioelectric-asymmetric-conveyed-fields-and-human-adipose-derived-stem-cells-obtained-with-a-nonenzymatic-method-and-device-a-novel-approach-to-multipotency
#8
Margherita Maioli, Salvatore Rinaldi, Sara Santaniello, Alessandro Castagna, Gianfranco Pigliaru, Alessandro Delitala, Francesca Bianchi, Carlo Tremolada, Vania Fontani, Carlo Ventura
Human adipose-derived stem cells (hASCs) have been recently proposed as a suitable tool for regenerative therapies for their simple isolation procedure and high proliferative capability in culture. Although hASCs can be committed into different lineages in vitro, the differentiation is a low-yield and often incomplete process. We have recently developed a novel nonenzymatic method and device, named Lipogems, to obtain a fat tissue derivative highly enriched in pericytes/mesenchymal stem cells by mild mechanical forces from human lipoaspirates...
2014: Cell Transplantation
https://www.readbyqxmd.com/read/23051701/a-new-nonenzymatic-method-and-device-to-obtain-a-fat-tissue-derivative-highly-enriched-in-pericyte-like-elements-by-mild-mechanical-forces-from-human-lipoaspirates
#9
Francesca Bianchi, Margherita Maioli, Erika Leonardi, Elena Olivi, Gianandrea Pasquinelli, Sabrina Valente, Armando J Mendez, Camillo Ricordi, Mirco Raffaini, Carlo Tremolada, Carlo Ventura
Adipose tissue contains multipotent elements with phenotypic and gene expression profiles similar to human mesenchymal stem cells (hMSCs) and pericytes. The chance of clinical translation of the multilineage potential of these cells is delayed by the poor/negligible cell survival within cryopreserved lipoaspirates, the difficulty of ex vivo expansion, and the complexity of current Good Manufacturing Practice (cGMP) requirements for expanded cells. Hence, availability of a minimally manipulated, autologous, hMSC/pericyte-enriched fat product would have remarkable biomedical and clinical relevance...
2013: Cell Transplantation
https://www.readbyqxmd.com/read/19628292/phase-ii-study-of-liposomal-cisplatin-lipoplatin-plus-gemcitabine-versus-cisplatin-plus-gemcitabine-as-first-line-treatment-in-inoperable-stage-iiib-iv-non-small-cell-lung-cancer
#10
RANDOMIZED CONTROLLED TRIAL
N Mylonakis, A Athanasiou, N Ziras, J Angel, A Rapti, S Lampaki, N Politis, C Karanikas, C Kosmas
BACKGROUND: Lipoplatin is a new liposomal cisplatin designed to reduce cisplatin toxicities without reducing efficacy. In the present randomized phase II study, we examined the efficacy and safety of a Lipoplatin-gemcitabine versus a cisplatin-gemcitabine combination as first line treatment in advanced NSCLC. PATIENTS AND METHODS: Patients with advanced (stages IIIB-IV) NSCLC received up to six 21-day cycles of Lipoplatin 120 mg/m(2) (days 1, 8, 15) and gemcitabine 1000 mg/m(2) (days 1+8) (arm A; LipoGem) versus cisplatin 100mg/m(2) (day 1) and gemcitabine 1000 mg/m(2) (days 1+8) (arm B; CisGem)...
May 2010: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
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