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recurrent pregnancy loss thyroid

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https://www.readbyqxmd.com/read/27668201/etiologic-characteristics-and-index-pregnancy-outcomes-of-recurrent-pregnancy-losses-in-korean-women
#1
Gi Su Lee, Joon Cheol Park, Jeong Ho Rhee, Jong In Kim
OBJECTIVE: The goal of this study was to evaluate the etiologies and clinical outcomes of Korean recurrent pregnancy loss (RPL) patients. And also, we investigated the differences between primary and secondary RPL patients, between two and three or more pregnancy losses. METHODS: One hundred seventy eight women diagnosed as RPL were enrolled. We performed chromosomal analysis, thyroid stimulating hormone, prolactin, blood glucose, plasminogen activator inhibitor-1, natural killer cell proportion, anticardiolipin antibodies, antiphospholipid antibodies, lupus anticoagulant, anti-β2glycoprotein-1 antibodies, antinuclear antibody, protein C, protein S, antithrombin III, homocysteine, MTFHR gene, factor V Leiden mutation, and hysterosalphingography/hysteroscopic evaluation...
September 2016: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/27127734/endocrine-dysfunction-and-recurrent-spontaneous-abortion-an-overview
#2
Ramandeep Kaur, Kapil Gupta
Miscarriage is the spontaneous loss of a fetus before it is viable, occurring at a rate of 15-20%. Recurrent spontaneous abortion (RSA) or habitual miscarriage is defined as repeated occurrence of 3 or more miscarriages before 20(th) week of gestation accounting for the most common complication of early pregnancy in humans. Various etiological factors responsible for recurrent miscarriage are anatomical, genetical, endocrinological, immunological, and infectious. The endocrinological abnormalities may be polycystic ovarian syndrome, hyperprolactinemia, luteal phase defect, thyroid dysfunction, diabetes, or hyperandrogenism contributing to recurrent pregnancy loss...
April 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27039249/pregnancy-loss-french-clinical-practice-guidelines
#3
EDITORIAL
C Huchon, X Deffieux, G Beucher, P Capmas, X Carcopino, N Costedoat-Chalumeau, A Delabaere, V Gallot, E Iraola, V Lavoue, G Legendre, V Lejeune-Saada, J Leveque, S Nedellec, J Nizard, T Quibel, D Subtil, F Vialard, D Lemery
In intrauterine pregnancies of uncertain viability with a gestational sac without a yolk sac (with a mean of three orthogonal transvaginal ultrasound measurements <25mm), the suspected pregnancy loss should only be confirmed after a follow-up scan at least 14 days later shows no embryo with cardiac activity (Grade C). In intrauterine pregnancies of uncertain viability with an embryo <7mm on transvaginal ultrasound, the suspected pregnancy loss should only be confirmed after a follow-up scan at least 7 days later (Grade C)...
June 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/26952510/systemic-inflammation-and-autoimmunity-in-women-with-chronic-endometritis
#4
Vitaly A Kushnir, Shirley Solouki, Tal Sarig-Meth, Mario G Vega, David F Albertini, Sarah K Darmon, Liane Deligdisch, David H Barad, Norbert Gleicher
PROBLEM: To determine in women with recurrent pregnancy loss (RPL) and/or implantation failure (RIF) the prevalence of chronic endometritis (CE), systemic inflammation and autoimmunity, and whether they relate. METHOD OF STUDY: This retrospective study examined inflammatory (adiponectin, CRP, leptin, and IL6) and autoimmune (total immunoglobulins, ANA, thyroid antibodies, antiphospholipid antibodies) markers in a group of 55 women with RPL/RIF. A diagnosis of CE was reached by endometrial biopsy, demonstrating CD138-positive plasma cells on histology...
June 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/26555345/thiol-disulfide-homeostasis-in-patients-with-idiopathic-recurrent-pregnancy-loss-assessed-by-a-novel-assay-report-of-a-preliminary-study
#5
Kudret Erkenekli, Cem Yasar Sanhal, Aykan Yucel, Cemile Koca Bicer, Ozcan Erel, Dilek Uygur
AIM: To evaluate the relationship between idiopathic recurrent pregnancy loss (RPL) and oxidative stress (OS) by means of thiol/disulfide homeostasis via a novel technique. METHODS: Thirty-nine pregnant women diagnosed with idiopathic RPL were compared with 50 healthy pregnant women without a history of abortion. Idiopathic RPL was defined as experiencing two or more consecutive miscarriages prior to 20 weeks of gestation with the presence of normal karyotypes of couple and/or abortus materials, negative maternal screening for anticardiolipin, anti β 2 glycoprotein antibodies and lupus anticoagulant, normal thyroid stimulating hormone, prolactin and hemoglobin A1C levels and normal pelvic sonography and/or hysterosalpingography...
February 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/26381475/does-the-presence-of-autoantibodies-without-autoimmune-diseases-and-hereditary-thrombophilia-have-an-effect-on-recurrent-pregnancy-loss
#6
Sezcan Mumusoglu, Mehmet Sinan Beksac, Ali Ekiz, Pinar Ozdemir, Gulsen Hascelik
OBJECTIVE: To assess whether the presence of autoantibodies has any effect on recurrent pregnancy loss (RPL) and obstetric complications in women who do not have autoimmune diseases and hereditary thrombophilia. METHODS: Retrospectively, 515 patients who underwent antibody investigation with anti-nuclear antibody, extractable nuclear antigen, anti-double stranded DNA, anti-parietal cell, anti-smooth muscle, anti-mitochondrial (AMA), anti-thyroid peroxidase, anti-thyroglobulin (anti-TG) and anti-phospholipid (aPL) at Hacettepe University were included...
2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/26118022/-peculiarities-of-the-course-of-pregnancy-the-implications-of-delivery-in-women-with-preeclampsia-in-the-conditions-of-natural-iodine-deficiency
#7
G V Fedynchuk, V A Maliar
The level of preeclampsia in 2.2 times higher in mountain regions as compared with lowland. In the presence of concomitant pathology of the thyroid gland on a background of natural iodine deficiency in pregnancy complicated with recurrent pregnancy loss in 2.8 times more primary placental insufficiency in 3.6 times, oligohydramnios 1.5 times, premature rupture of the amniotic fluid in 1.9 times, anemia, preeclampsia develops at earlier periods of gestation and more difficult to correct medication, in most cases becomes more severe...
January 2015: Likars'ka Sprava
https://www.readbyqxmd.com/read/26025471/the-effect-of-thyroid-autoimmunity-on-t-cell-responses-in-early-pregnancy
#8
Ozlem Turhan Iyidir, Ceyla Konca Degertekin, Cemile Sonmez, Ayşegül Atak Yucel, Mehmet Erdem, Mujde Akturk, Goksun Ayvaz
Thyroid autoimmunity (TAI) is common in women of reproductive age. There is a relationship between TAI and recurrent pregnancy loss and infertility. In pregnant patients with thyroid autoimmunity, the T helper-1 (Th1)/T helper-2 (Th2) ratio may shift to a Th1-type response and these activated T lymphocytes may lead to implantation failure. The aims of this study were to investigate the serum levels of Th1-, Th2-, and T-helper-17-(Th17)-associated cytokines in pregnant patients with TAI, and to evaluate how these cytokines change with l-thyroxin treatment during pregnancy...
August 2015: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/25910570/gestational-hypothyroidism-development-of-mild-hypothyroidism-in-early-pregnancy-in-previously-euthyroid-women
#9
COMPARATIVE STUDY
Karen R Hammond, Nicholas A Cataldo, Janice A Hubbard, Beth A Malizia, Michael P Steinkampf
OBJECTIVE: To determine the proportion of euthyroid women attending a fertility practice who develop hypothyroidism in very early pregnancy (gestational hypothyroidism [GHT]), and to examine the association of GHT with exogenous gonadotropin treatment. DESIGN: Retrospective cohort study. SETTING: A private reproductive medicine practice. PATIENT(S): All healthy women (N = 94) with infertility or recurrent pregnancy loss, TSH level <2...
June 2015: Fertility and Sterility
https://www.readbyqxmd.com/read/25814482/expression-of-thyroid-hormone-receptors-in-villous-trophoblasts-and-decidual-tissue-at-protein-and-mrna-levels-is-downregulated-in-spontaneous-and-recurrent-miscarriages
#10
Brigitte Ziegelmüller, Aurelia Vattai, Bernd Kost, Christina Kuhn, Simone Hofmann, Birgit Bayer, Bettina Toth, Udo Jeschke, Nina Ditsch
Thyroid hormones are essential for the maintenance of pregnancy, and a deficiency in maternal thyroid hormones has been associated with early pregnancy losses. The expression of THRα1, THRβ1 and THRα2 increases with gestational age. The aim of this study was the investigation of the protein and mRNA-levels of THR isoforms THRα1, THRα2, THRβ1 and THRβ2 in normal, spontaneous and recurrent miscarriages. The identification of THR-expressing cells in the decidua was done with double immunofluorescence. The nuclear expression of THRα1, THRα2, THRβ1 and THRβ2 is downregulated at protein level in spontaneous and recurrent miscarriages in villous trophoblast tissue...
July 2015: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/25246900/treatment-of-recurrent-pregnancy-loss-by-levothyroxine-in-women-with-high-anti-tpo-antibody
#11
Mohammad Hosein Mosaddegh, Nasrin Ghasemi, Tahere Jahaninejad, Fatemeh Mohsenifar, Abbas Aflatoonian
BACKGROUND: Recurrent pregnancy loss (RPL) is defined as two or more consecutive pregnancy losses before twenty weeks of gestation. It is caused by a variety of genetics and non-genetics factors. Thyroid autoimmunity could associate with pregnancy loss. OBJECTIVE: To investigate the effectiveness of Levothyroxine in treatment of RPL in women with high auto-thyroid antibodies. MATERIALS AND METHODS: In this observational cross sectional study, 900 women who had a history of recurrent pregnancy loss were studied...
July 2012: Iranian Journal of Reproductive Medicine
https://www.readbyqxmd.com/read/25079455/hormonal-causes-of-recurrent-pregnancy-loss-rpl
#12
REVIEW
Nicola Pluchino, Panagiotis Drakopoulos, Jean Marie Wenger, Patrick Petignat, Isabelle Streuli, Andrea Riccardo Genazzani
Endocrine disorders play a major role in approximately 8% to 12% of recurrent pregnancy loss (RPL). Indeed, the local hormonal milieu is crucial in both embryo attachment and early pregnancy. Endocrine abnormalities, including thyroid disorders, luteal phase defects, polycystic ovary syndrome, hyperprolactinaemia and diabetes have to be evaluated in any case of RPL. Moreover, elevated androgen levels and some endocrinological aspects of endometriosis are also factors contributing to RPL. In the present article, we review the significance of endocrine disease on RPL...
July 2014: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/24680363/recurrent-miscarriages-innate-immunity-and-autoimmune-reaction-to-chlamydial-60-kda-heat-shock-protein-is-there-an-association
#13
Waltraud Eggert-Kruse, Sandra Scholz, Michael Kirschfink, Thomas Strowitzki
OBJECTIVE: To evaluate a potential association of immunity to the Chlamydia trachomatis 60kDa heat shock protein (ChlamHSP60) and recurrent miscarriages. DESIGN: Prospective study. SETTING: Outpatient miscarriage clinic of a university-based hospital. PATIENT(S): 120 asymptomatic women with a history of recurrent miscarriages. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Determination of serum immunoglobulin G (IgG) antibodies (Ab) to ChlamHSP60 and human HSP60 and, in parallel, mannose-binding lectin (MBL) and the total hemolytic complement (CH50); medical history and clinical examination, including multiple relevant laboratory determinants...
June 2014: Fertility and Sterility
https://www.readbyqxmd.com/read/24491986/endocrine-basis-for-recurrent-pregnancy-loss
#14
REVIEW
Raymond W Ke
Common endocrinopathies are a frequent contributor to spontaneous and recurrent miscarriage. Although the diagnostic criteria for luteal phase defect (LPD) is still controversial, treatment of patients with both recurrent pregnancy loss and LPD using progestogen in early pregnancy seems beneficial. For patients who are hypothyroid, thyroid hormone replacement therapy along with careful monitoring in the preconceptual and early pregnancy period is associated with improved outcome. Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy loss...
March 2014: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/24464014/the-occurrence-of-immunological-disturbances-in-patients-with-recurrent-miscarriage-rm-of-unknown-etiology
#15
Hanna Motak-Pochrzest, Andrzej Malinowski
OBJECTIVE: The 155 patients suffering from primary RM who took part in this study were qualified after excluding known causes of abortions. METHODS: The presence of the following immunological factors was examined in serum samples: autoantibodies such as anti-cardiolipin (ACA) IgG and IgM, lupus-anticoagulant (LA), anti-thyroid (ATA): anti-thyroglobulin (anti-TG) and anti-thyroid peroxydase (anti-TPO), anti-nuclear (ANA), anti-placental (APA) antibodies and alloimmunological disturbances following HLA-class I antibody test (LCT-lymphocytotoxic test), lack of blocking proliferative activity in mixed lymphocyte reaction test (MLR), anti-sperm (ASA) antibodies, levels of extracellular interferon γ (IFN γ) and tumour necrosis α (TNFα) produced by peripheral blood lymphocytes...
2013: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/24449669/clinical-aspects-of-hyperthyroidism-hypothyroidism-and-thyroid-screening-in-pregnancy
#16
REVIEW
Roberto Negro, Alex Stagnaro-Green
OBJECTIVE: To evaluate the peer-reviewed literature on hypothyroidism, hyperthyroidism, and thyroid autoimmunity in pregnancy. METHODS: We review published studies on thyroid autoimmunity and dysfunction in pregnancy, the impact of thyroid disease on pregnancy, and discuss implications for screening. RESULTS: Overt hyperthyroidism and hypothyroidism are responsible for adverse obstetric and neonatal events. Several studies of association suggest that either subclinical hypothyroidism or thyroid autoimmunity increase the risk of complications...
June 2014: Endocrine Practice
https://www.readbyqxmd.com/read/24265336/recurrent-symptomatic-hypoglycaemia-with-pancytopenia-as-a-delayed-presentation-of-sheehan-s-syndrome-with-complete-recovery-after-hormone-replacement
#17
Pramila Dharmshaktu, Jayeeta Bhowmick, Danny Manglani, Dinesh Kumar Dhanwal
A 38-year-old woman presented to our hospital emergency section in altered sensorium and with blood pressure of 80/60 mm Hg. She gave a history of recurrent episodes of loss of consciousness for 15-20 days, generalised body swelling and generalised weakness for the past 5-6 years. On further evaluation she was found to have severe hypoglycaemic episodes. In view of history of pregnancy and significant blood loss during surgery and long history of lethargy, asthaenia and generalised anasarca, the patient was evaluated for Sheehan's syndrome...
2013: BMJ Case Reports
https://www.readbyqxmd.com/read/23954357/impact-of-subclinical-hypothyroidism-in-women-with-recurrent-early-pregnancy-loss
#18
COMPARATIVE STUDY
Lia A Bernardi, Ronald N Cohen, Mary D Stephenson
OBJECTIVE: To assess the impact of subclinical hypothyroidism (SCH) in women with recurrent early pregnancy loss (REPL). DESIGN: Observational cohort study. SETTING: REPL program in an academic medical center. PATIENT(S): 286 women with a history of ≥2 pregnancy losses <10 weeks. INTERVENTION(S): From 2004-2007, no treatment for women with SCH (thyroid-stimulating hormone [TSH] >2.5 mIU/L with a normal free thyroxine or free thyroxine index); from 2008 onward, levothyroxine treatment prepregnancy to maintain TSH ≤2...
November 2013: Fertility and Sterility
https://www.readbyqxmd.com/read/23738229/management-of-thyroid-peroxidase-antibody-euthyroid-women-in-pregnancy-comparison-of-the-american-thyroid-association-and-the-endocrine-society-guidelines
#19
L Mehran, M Tohidi, F Sarvghadi, H Delshad, A Amouzegar, O P Soldin, F Azizi
The presence of thyroid autoantibodies is relatively high in women of childbearing age. There is evidence that positive thyroperoxidase antibody even in euthyroid women may increase the risk of spontaneous and recurrent pregnancy loss and preterm delivery. However, the evidence is not enough to justify recommendation on the screening of pregnant women for thyroid autoantibodies or LT4 supplementation for reducing maternal or fetal complications. In this paper we reviewed the related evidence and compared the new guidelines of the American Thyroid Association and Endocrine Society with respect to the screening and management of positive thyroperoxidase antibody in euthyroid pregnant women...
2013: Journal of Thyroid Research
https://www.readbyqxmd.com/read/23691843/prevalence-of-subclinical-and-undiagnosed-overt-hypothyroidism-in-a-pregnancy-loss-clinic
#20
A S Khalid, C Joyce, K O'Donoghue
Recent studies have associated pregnancy loss with subclinical hypothyroidism, defined as elevated thyroid-stimulating-hormone level, with normal free thyroxine. In overt hypothyroidism, the free thyroxine is low. Subclinical and overt hypothyroidism occurs in 0.25-2.5% and 0.2-0.3% of pregnancies respectively. We examined the prevalence of subclinical and undiagnosed overt hypothyroidism in women with recurrent miscarriage, late miscarriage and stillbirth attending the Pregnancy Loss Clinic. Data was collected from the Pregnancy Loss Clinic records...
April 2013: Irish Medical Journal
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