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Oxymetazoline

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https://www.readbyqxmd.com/read/27748955/nasal-decongestants-in-monotherapy-for-the-common-cold
#1
REVIEW
Laura Deckx, An Im De Sutter, Linda Guo, Nabiel A Mir, Mieke L van Driel
BACKGROUND: Many treatments for the common cold exist and are sold over-the-counter. Nevertheless, evidence on the effectiveness and safety of nasal decongestants is limited. OBJECTIVES: To assess the efficacy, and short- and long-term safety, of nasal decongestants used in monotherapy to alleviate symptoms of the common cold in adults and children. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, Issue 6, June 2016), which contains the Cochrane Acute Respiratory Infections (ARI) Specialised Register, MEDLINE (1946 to July 2016), Embase (2010 to 15 July 2016), CINAHL (1981 to 15 July 2016), LILACS (1982 to July 2016), Web of Science (1955 to July 2016) and clinical trials registers...
October 17, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27650973/mechanistic-insight-into-the-norepinephrine-induced-fibrosis-in-systemic-sclerosis
#2
Akihito Uehara, Sei-Ichiro Motegi, Kazuya Yamada, Akihiko Uchiyama, Buddhini Perera, Sayaka Toki, Sachiko Ogino, Yoko Yokoyama, Yuko Takeuchi, Osamu Ishikawa
Raynaud's phenomenon is frequently observed in systemic sclerosis (SSc) patients, and cold- or stress-induced norepinephrine (NE) has been speculated to be associated with vasoconstriction. Objective was to elucidate the role of NE in fibrosis in SSc. IL-6 is a potent stimulator of collagen production in fibroblasts. NE enhanced IL-6 production and proliferation more significantly in SSc fibroblasts than in normal fibroblasts. Furthermore, the production of IL-6 and phosphorylation of p38 in SSc fibroblasts was enhanced by adrenergic receptor (AR)β agonist, isoproterenol, but not ARα agonist, oxymetazoline...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27646144/intranasal-tetracaine-and-oxymetazoline-a-newly-approved-drug-formulation-that-provides-maxillary-dental-anesthesia-without-needles
#3
Elliot V Hersh, Mana Saraghi, Paul A Moore
BACKGROUND: An intranasal formulation of 3% tetracaine and 0.05% oxymetazoline (Kovanaze) received FDA approval on 29 June 2016. This formulation appears to provide sufficient local anesthesia to perform routine dental restorative (filling) procedures in maxillary teeth from second premolar forward. OBJECTIVES: The aim of this paper is to provide an overview of the efficacy, pharmacokinetics and tolerability of 3% tetracaine plus 0.05% oxymetazoline when administered intranasally...
October 3, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27621136/simultaneous-determination-of-cromolyn-sodium-combined-dosage-forms-using-isocratic-hplc-method
#4
M E Fathy, S Abo El Abass Mohamed, H Elmansi, F Belal
A simple and selective reversed-phase high-performance liquid chromatography method was developed for the estimation of cromolyn sodium (CRM) with either oxymetazoline hydrochloride (OMZ) or xylometazoline hydrochloride (XMZ) in their binary mixtures. The method is based on the simultaneous separation of each drug in a reversed-phase Waters symmetry(®) C18 column (250 mm × 4.6 mm intradermally, 5-µm particle size) at 25°C. Elution was performed with a mobile phase consisting of methanol : 0.1 M phosphate buffer (60:40, v/v, pH 4...
September 12, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27459198/premedication-methods-in-nasal-endoscopy-a-prospective-randomized-double-blind-study
#5
Mehmet İlhan Şahin, Kerem Kökoğlu, Şafak Güleç, İbrahim Ketenci, Yaşar Ünlü
Objectives: To identify the optimal pharmacological method of preparing patients for nasal endoscopy. Methods: Twenty healthy volunteers were enrolled in this prospective, randomized, double-blind study. Four types of medications were applied in their nostrils with binary combinations of spray bottles on four different days in a random order: placebo (normal saline [NS]+NS), decongestant (NS+oxymetazoline), anesthetic (NS+lidocaine), and decongestant plus anesthetic (oxymetazoline+lidocaine)...
July 27, 2016: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/27453703/oxymetazoline-metered-dose-spray-factors-affecting-delivery-volume
#6
Mumin Hakim, Hina Walia, Mahmood Rafiq, Timothy Grannell, Richard S Cartabuke, Joseph D Tobias
OBJECTIVES: The current study compared the amount of oxymetazoline delivered by various anesthesia providers when holding the bottle in the upright and inverted position. Additionally, the amount delivered from a full bottle and a half-full bottle was also investigated. METHODS: Using an analytical balance that was calibrated to zero, we evaluated the impact the position of the bottle and the volume of oxymetazoline in the bottle had on the amount being delivered by both anesthesia staff and trainees...
May 2016: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/27436060/population-pharmacokinetics-of-an-intra-nasally-administered-combination-of-oxymetazoline-and-tetracaine-k305-in-healthy-volunteers
#7
Anthony T Cacek, Jogarao V S Gobburu, Mathangi Gopalakrishnan
The primary objective of the current investigation was to establish the pharmacokinetic characteristics of oxymetazoline and tetracaine's primary metabolite, para-butylaminobenzoic acid (PBBA), after the intranasal administration of K305. Thirty six subjects contributing a total of 1791 plasma concentration results from two open label trials were utilized. Model development was achieved using data from the second trial (N = 24) in which 0.3 mg oxymetazoline/18 mg tetracaine was administered. External model validation utilized data from the first trial (N = 12) which included doses of 0...
July 19, 2016: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27333590/the-setting-time-of-polyether-impression-materials-after-contact-with-conventional-and-experimental-gingival-margin-displacement-agents
#8
Danuta Nowakowska, Zbigniew Raszewski, Marek Ziętek, Jolanta Saczko, Julita Kulbacka, Włodzimierz Więckiewicz
PURPOSE: The compatibility of chemical gingival margin displacement agents with polyether impression materials has not been determined. The aim of this study was to evaluate the setting time of polyether impression elastomers after contact with conventional and experimental gingival displacement agents. MATERIALS AND METHODS: The study compared the setting time of two polyether impression materials: medium body (Impregum Penta Soft) and light body (Impregum Garant L DuoSoft) after contact with 10 gingival displacement agents, including 5 conventional astringents (10%, 20%, and 25% aluminum chloride, 25% aluminum sulfate, and 15...
June 22, 2016: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/27216350/does-oxymetazoline-increase-the-efficacy-of-nasal-steroids-in-treating-nasal-polyposis
#9
Virat Kirtsreesakul, Thitiporn Khanuengkitkong, Suwalee Ruttanaphol
BACKGROUND: Although nasal steroids are the mainstay treatments in nasal polyposis, up to one-half of patients do not respond and need surgical treatment. This study aimed to evaluate whether oxymetazoline administration produces any additive effect on nasal steroid therapy and whether rebound congestion develops after oxymetazoline treatment. METHODS: Sixty-eight patients with nasal polyposis were randomly assigned in a 1:1 ratio to receive either oxymetazoline plus mometasone furoate nasal spray (MFNS) or placebo plus MFNS, 2 sprays per nostril twice daily, with an interval of 5 minutes between each medication for 4 weeks...
May 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/27156558/recurrent-apnea-in-a-neonate-following-intranasal-oxymetazoline
#10
Shridhar Gopalakrishnan, Kirandeep Sodhi
No abstract text is available yet for this article.
April 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27087030/prenatal-diagnosis-and-physical-model-reconstruction-of-agnathia-otocephaly-with-limb-deformities-absent-ulna-fibula-and-digits-following-maternal-exposure-to-oxymetazoline-in-the-first-trimester
#11
Gláucia Aparecida Menezes, Edward Araujo Júnior, Jorge Lopes, Simone Belmonte, Gabriele Tonni, Heron Werner
Agnathia-otocephaly or agnathia-sinotia-microstomy syndrome is the most severe malformation affecting the first branchial arch. It is a rare congenital anomaly characterized by absence of the lower jaw and abnormal ear positioning. Prenatal diagnosis is possible on conventional 2-D ultrasound in the second trimester. Three-dimensional ultrasound enhances detection of abnormal facial phenotype, especially in surface rendering mode. In addition, 3-D volume datasets are used to produce a physical model of the anomaly...
August 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27041896/effect-of-various-chemical-agents-used-in-gingival-retraction-systems-on-smear-layer-scanning-electron-microscope-study
#12
Krishna Shivraj Lahoti
BACKGROUND: Chemical agents used for gingival retraction affects the smear layer. AIM: To determine the effect of three different chemical agents used for gingival retraction systems on smear layer. MATERIALS AND METHODS: Four human premolars were prepared using air-rotor with air-water spray to receive full crown restoration. Three of them were treated with 21.3% aluminum chloride for 10 min, 0.05% oxymetazoline hydrochloride for 10 min, and expasyl for 2 min, respectively...
January 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/26994623/the-effectiveness-of-oxymetazoline-plus-intranasal-steroid-in-the-treatment-of-chronic-rhinitis-a-randomised-controlled-trial
#13
RANDOMIZED CONTROLLED TRIAL
Torpong Thongngarm, Paraya Assanasen, Panitan Pradubpongsa, Pongsakorn Tantilipikorn
BACKGROUND: The recommended drug for moderate to severe chronic rhinitis is intranasal steroids (INS). However, nasal congestion could be refractory and need additional treatments. OBJECTIVE: We sought to explore the benefit of oxymetazoline (Oxymet) plus INS on nasal congestion without inducing rhinitis medicamentosa. METHODS: We performed a 60-week, randomised, double-blind clinical trial in 50 patients, 18 years of age or greater, with chronic rhinitis who had used INS and cetirizine and still had nasal congestion...
March 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/26946996/effects-of-benzalkonium-chloride-on-histamine-h1-receptor-mrna-expression-in-nasal-epithelial-cells
#14
Masaki Kawabata, Junichiro Ohori, Yuichi Kurono
OBJECTIVE: To better understand the causes of the exacerbation of rhinitis medicamentosa (RM) induced by oxymetazoline (OMZ) or benzalkonium chloride (BKC), we examined the impact of pretreatment with OMZ or BKC on cultured human nasal epithelial cells. We also examined the effect of mometasone furoate (MF) on the cultured human nasal epithelial cells treated with OMZ or BKC. METHODS: Cells of the human nasal epithelial cell line HNEpC were treated with OMZ or BKC, and the OMZ- and BKC-induced expression of histamine H1 receptor (H1R) mRNA was assayed using real-time polymerase chain reaction...
December 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/26923703/usefulness-of-rhinomanometry-in-the-identification-and-treatment-of-patients-with-obstructive-sleep-apnoea-an-algorithm-for-predicting-the-relationship-between-nasal-resistance-and-continuous-positive-airway-pressure-a-retrospective-study
#15
J Hueto, F Santaolalla, A Sanchez-Del-Rey, A Martinez-Ibargüen
OBJECTIVES: We tried to assess the relationship between nasal resistance measured by rhinomanometry and the pressure used in CPAP. DESIGN: Retrospective medical case series review, January 2004 to December 2014. SETTING: Tertiary care academic medical centre. PARTICIPANTS: Thirty-eight patients (m = 56.55 years; male = 90.5%) with CPAP settings ≤8 and 39 patients (m = 57.49 years; male = 74.9%) with pressure settings ≥12...
December 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/26892312/comparison-of-3-intranasal-mists-for-anesthetizing-maxillary-teeth-in-adults-a-randomized-double-masked-multicenter-phase-3-clinical-trial
#16
Sebastian G Ciancio, Adam D Marberger, Fadi Ayoub, Davis A Garlapo, Eugene A Pantera, Carole T Pantera, Sultan Al-Mubarak, Benita D Sobieraj, David Y He, Srinivas R Myneni
BACKGROUND: This double-masked, parallel-design, clinical trial assessed whether a combination nasal spray (K305; 3% tetracaine hydrochloride and 0.05% oxymetazoline hydrochloride) compared with a tetracaine-only spray and a placebo spray would be safer and superior in producing local anesthesia sufficient to complete a direct restorative procedure in maxillary nonmolar teeth. METHODS: The authors randomized eligible patients to receive K305 spray (n = 44), tetracaine hydrochloride spray (n = 44), or a placebo solution (n = 22)...
May 2016: Journal of the American Dental Association
https://www.readbyqxmd.com/read/26822100/double-masked-randomized-placebo-controlled-study-to-evaluate-the-efficacy-and-tolerability-of-intranasal-k305-3-tetracaine-plus-0-05-oxymetazoline-in-anesthetizing-maxillary-teeth
#17
Elliot V Hersh, Andres Pinto, Mana Saraghi, Najeed Saleh, Lisbeth Pulaski, Sharon M Gordon, Douglas Barnes, Gary Kaplowitz, Ira Bloom, Mohammad Sabti, Paul A Moore, Sean Lee, Michael Meharry, David Y He, Yiming Li
BACKGROUND: The authors compared the local anesthetic efficacy and safety of an intranasally administered formulation of tetracaine and oxymetazoline (K305) with placebo in adult participants undergoing single dental restorative procedures in teeth nos. 4 through 13. METHODS: The authors screened and allocated 150 participants in a double-masked, randomized fashion to either K305 or placebo nasal spray. The authors delivered the study drug as two 0.2-milliliter sprays separated by 4 minutes inside the nostril on the side ipsilateral to the tooth being treated...
April 2016: Journal of the American Dental Association
https://www.readbyqxmd.com/read/26741127/effects-of-the-inverse-alpha-agonist-doxazosin-in-allergic-rhinitis
#18
A Manoharan, A E Morrison, B J Lipworth
BACKGROUND: We examined the paradoxical hypothesis that the alpha-receptor inverse agonist doxazosin might produce beneficial effects in allergic rhinitis. OBJECTIVES: To evaluate single and chronic dosing effects of doxazosin on nasal airflow and symptoms in allergic rhinitis. METHODS: Fifteen patients randomized to receive 3-5 weeks of oral doxazosin 4 mg daily or placebo in crossover fashion. Measurements were taken at baseline and after first and last doses...
May 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/26611245/oxymetazoline-applied-topically-to-the-nasal-mucosa-decreases-trans-mucosal-nitrous-oxide-exchange-for-the-middle-ear
#19
Miriam S Teixeira, Cuneyt M Alper, Brian S Martin, Narmin Helal, Brendan M Cullen Doyle, William J Doyle
OBJECTIVE: Determine if the middle ear (ME) trans-mucosal nitrous oxide (N2O) gas exchange rate can be pharmacologically modulated by the nasal application of a vasoconstrictor. METHODS: In a randomized, double-blind, crossover study, 20 adults received a nasal spray challenge containing either oxymetazoline or saline (placebo). At each session, subjects were fitted with a non-rebreathing mask and breathed room air for 20 minutes, 50% N2O:50% O2 for 20 minutes, and 100% O2 for 10 minutes...
May 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/26522979/not-just-a-drop-in-the-bucket-inversion-of-oxymetazoline-nasal-decongestant-container-increases-potential-for-severe-pediatric-poisoning
#20
COMPARATIVE STUDY
Sean Patrick Nordt, Lisa E Vivero, F Lee Cantrell
Oxymetazoline is an over-the-counter nasal decongestant with potent alpha agonist properties. In overdoses as small as 1-2 mL, toxicity can be seen including bradycardia and respiratory depression. We demonstrated that inverting the container increased the volume delivered 20- to 30-fold compared with holding it upright in an in vitro model.
January 2016: Journal of Pediatrics
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