Yun Jiang, Xuekun Ren, Jiajie Mao, Jun Zeng, Wanying Jiang, Runqi Zhou, Yue Han, Hongning Wang, Yixin Mao, Xiaoyu Sun, Zelin Cao, Zengqiang Song, Shengbin Huang, Shufan Zhao
Periodontitis, the second most common oral disease, is primarily initiated by inflammatory responses and osteoclast differentiation, in which the MAPK signaling pathway and mitochondrial function play important roles. 3-methyl-1H-indol-1-yl dimethylcarbamodithioate (3o), a hybrid of indole and dithiocarbamate, was first synthesized by our group. It has shown anti-inflammatory activity against lipopolysaccharide-induced acute lung injury. However, it is not known if 3o can exert effects in periodontitis. In vitro study: LPS-induced macrophage inflammation initiation and a receptor activator of nuclear factor κB ligand-stimulated osteoclast differentiation model were established...
March 29, 2024: Journal of Periodontal Research