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Reactive oxygen species, lung disease

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https://www.readbyqxmd.com/read/27831562/mitochondrial-transfer-of-mesenchymal-stem-cells-effectively-protects-corneal-epithelial-cells-from-mitochondrial-damage
#1
Dan Jiang, Fei Gao, Yuelin Zhang, David Sai Hung Wong, Qing Li, Hung-Fat Tse, Goufeng Xu, Zhendong Yu, Qizhou Lian
Recent studies have demonstrated that mesenchymal stem cells (MSCs) can donate mitochondria to airway epithelial cells and rescue mitochondrial damage in lung injury. We sought to determine whether MSCs could donate mitochondria and protect against oxidative stress-induced mitochondrial dysfunction in the cornea. Co-culturing of MSCs and corneal epithelial cells (CECs) indicated that the efficiency of mitochondrial transfer from MSCs to CECs was enhanced by Rotenone (Rot)-induced oxidative stress. The efficient mitochondrial transfer was associated with increased formation of tunneling nanotubes (TNTs) between MSCs and CECs, tubular connections that allowed direct intercellular communication...
November 10, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27815873/single-cell-analysis-of-phagocytosis-phagosome-maturation-phagolysosomal-leakage-and-cell-death-following-exposure-of-macrophages-to-silica-particles
#2
Gaurav N Joshi, Renée M Gilberti, David A Knecht
Chronic inhalation of silica in various occupational settings results in the development of silicosis, a disease characterized by lung fibrosis. Uptake of silica particles by alveolar macrophages results in cell death and this is one of the contributing factors to the development of silicosis. We have characterized the uncoated or protein-coated (non-opsonized) and Fc receptor-mediated (antibody-opsonized) routes of silica phagocytosis and toxicity. Numerous microscopy techniques and fluorescent probes are outlined in this chapter to carefully measure particle uptake, by macrophages, phagosome maturation, phagosomal reactive oxygen species generation, phagolysosomal leakage, and cell death...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27815257/sirt3-blocks-myofibroblast-differentiation-and-pulmonary-fibrosis-by-preventing-mitochondrial-dna-damage
#3
Samik Bindu, Vinodkumar B Pillai, Abhinav Kanwal, Sadhana Samant, Gokhan Mutlu, Eric Verdin, Nickolai O Dulin, Mahesh P Gupta
Myofibroblast differentiation is a key process in the pathogenesis of fibrotic diseases. Transforming growth factor-β1 (TGFβ1) is a powerful inducer of myofibroblast differentiation and is implicated in pathogenensis of tissue fibrosis. This study was undertaken to determine the role of mitochondrial deacetylase, SIRT3 in TGF-β1-induced myofibroblast differentiqtion in vitro and lung fibrosis in vivo. Treatment of human lung fibroblasts with TGFβ1 resulted in increased expression of fibrosis markers, smooth muscle alpha-actin (α-SMA), collagen-1 and fibronectin...
November 4, 2016: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/27793104/n-acetyl-cysteine-exhibits-potent-anti-mycobacterial-activity-in-addition-to-its-known-anti-oxidative-functions
#4
Eduardo P Amaral, Elisabete L Conceição, Diego L Costa, Michael S Rocha, Jamocyr M Marinho, Marcelo Cordeiro-Santos, Maria Regina D'Império-Lima, Theolis Barbosa, Alan Sher, Bruno B Andrade
BACKGROUND: Mycobacterium tuberculosis infection is thought to induce oxidative stress. N-acetyl-cysteine (NAC) is widely used in patients with chronic pulmonary diseases including tuberculosis due to its mucolytic and anti-oxidant activities. Here, we tested whether NAC exerts a direct antibiotic activity against mycobacteria. METHODS: Oxidative stress status in plasma was compared between pulmonary TB (PTB) patients and those with latent M. tuberculosis infection (LTBI) or healthy uninfected individuals...
October 28, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27788581/environmental-tobacco-smoke-alters-metabolic-systems-in-adult-rats
#5
Dinesh Kumar Barupal, Kent E Pinkerton, Carol Hood, Tobias Kind, Oliver Fiehn
Human exposure to environmental tobacco smoke (ETS) is associated with an increased incidence of pulmonary and cardiovascular disease and possibly lung cancer. Metabolomics can reveal changes in metabolic networks in organisms under different physio-pathological conditions. Our objective was to identify spatial and temporal metabolic alterations with acute and repeated subchronic ETS exposure to understand mechanisms by which ETS exposure may cause adverse physiological and structural changes in the pulmonary and cardiovascular systems...
October 28, 2016: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/27785664/genetic-phagocyte-nadph-oxidase-deficiency-enhances-nonviable-candida-albicans-induced-inflammation-in-mouse-lungs
#6
Daiki Endo, Kenta Fujimoto, Rika Hirose, Hiroko Yamanaka, Mizuki Homme, Ken-Ichi Ishibashi, Noriko Miura, Naohito Ohno, Yasuaki Aratani
Patients with chronic granulomatous disease (CGD) have mutated phagocyte NADPH oxidase, resulting in reduced production of reactive oxygen species (ROS). While the mechanism underlying hyperinfection in CGD is well understood, the basis for inflammatory disorders that arise in the absence of evident infection has not been fully explained. This study aimed to evaluate the effect of phagocyte NADPH oxidase deficiency on lung inflammation induced by nonviable Candida albicans (nCA). Mice deficient in this enzyme (CGD mice) showed more severe neutrophilic pneumonia than nCA-treated wild-type mice, which exhibited significantly higher lung concentrations of interleukin (IL)-1β, tumor necrosis factor (TNF)-α, and keratinocyte-derived chemokine (KC)...
October 26, 2016: Inflammation
https://www.readbyqxmd.com/read/27779235/one-compound-of-saponins-from-disocorea-zingiberensis-protected-against-experimental-acute-pancreatitis-by-preventing-mitochondria-mediated-necrosis
#7
Rui Zhang, Li Wen, Yan Shen, Na Shi, Zhihua Xing, Qing Xia, Hai Niu, Wen Huang
Acute pancreatitis (AP) is a painful inflammatory disorder of the exocrine pancreas, ranking as the most common gastrointestinal reasons for hospitalization with no specific therapy currently. Diosgenyl saponins extracted from natural products and diosgenin or its derivatives have been shown to exert anti-inflammatory effects in various diseases. However, the therapeutic effects of diosgenyl saponins from Dioscorea zingiberensis C. H. Wright in AP have not yet been determined. Five compounds were extracted and screened for taurocholate-induced necrosis in mouse pancreatic acinar cells...
October 25, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27759648/mechanism-and-early-intervention-research-on-ali-during-emergence-surgery-of-stanford-type-a-aad-study-protocol-for-a-prospective-double-blind-clinical-trial
#8
Yi Cheng, Mu Jin, Xiuhua Dong, Lizhong Sun, Jing Liu, Rong Wang, Yanwei Yang, Peirong Lin, Siyu Hou, Yuehua Ma, Yuefeng Wang, Xudong Pan, Jiakai Lu, Weiping Cheng
BACKGROUND: Stanford type-A acute aortic dissection (AAD) is a severe cardiovascular disease demonstrating the characteristics of acute onset and rapid development, with high morbidity and mortality. The available evidence shows that preoperative acute lung injury (ALI) induced by Stanford type-A AAD is a frequent and important cause for a number of untoward consequences. However, there is no study assessing the incidence of preoperative ALI and its independent determinants before Standford type-A AAD surgery in Chinese adult patients...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27748837/an-indolylquinoline-derivative-activates-dna-damage-response-and-apoptosis-in-human-hepatocellular-carcinoma-cells
#9
Chun-Yen Liu, Chang-Hung Hsieh, Seung-Hun Kim, Jing-Ping Wang, Yu-Lin Ni, Chun-Li Su, Ching-Fa Yao, Kang Fang
Human liver cancer is one of the most frequently diagnosed cancers worldwide. The development of resistance to therapy limits the application against the disease. To improve treatment, new effective anticancer agents are constantly pursued. Previously, we reported that an indolylquinoline, 3-((7-ethyl-1H-indol-3-yl)-methyl)-2-methylquinoline (EMMQ), is effective in suppressing the growth of human lung cancer by impairing mitochondria functions. The present study revealed that EMMQ inhibited cell growth and induced apoptosis in liver cancer cells, but not in normal cells...
October 5, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/27717867/mkk3-influences-mitophagy-and-is-involved-in-cigarette-smoke-induced-inflammation
#10
Praveen Mannam, Navin Rauniyar, TuKiet T Lam, Ruiyan Luo, Patty J Lee, Anup Srivastava
Cigarette smoking is the primary risk factor for COPD which is characterized by excessive inflammation and airflow obstruction of the lung. While inflammation is causally related to initiation and progression of COPD, the mitochondrial mechanisms that underlie the associated inflammatory responses are poorly understood. In this context, we have studied the role played by Mitogen activated protein (MAP) kinase kinase 3 (MKK3), a dual-specificity protein kinase, in cigarette smoke induced-inflammation and mitochondrial dysfunction...
October 4, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27680676/cigarette-smoke-reversibly-activates-hypoxia-inducible-factor-1-in-a-reactive-oxygen-species-dependent-manner
#11
Hiroki Daijo, Yuma Hoshino, Shinichi Kai, Kengo Suzuki, Kenichiro Nishi, Yoshiyuki Matsuo, Hiroshi Harada, Kiichi Hirota
Cigarette smoke (CS) is a major contributor to the development of a large number of fatal and debilitating disorders. However, the precise molecular mechanisms underlying the effects of CS in lung disease are largely unknown. To elucidate these pathophysiological processes, we examined the in vitro and in vivo effects of CS extract (CSE) and CS on the transcription factor, hypoxia-inducible factor 1 (HIF-1). CSE induced concentration- and time-dependent accumulation of HIF-1α protein in human lung epithelial-like cells under non-hypoxic conditions...
September 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27678081/the-role-of-hypoxia-inducible-factor-1%C3%AE-in-zinc-oxide-nanoparticle-induced-nephrotoxicity-in-vitro-and-in-vivo
#12
Yuh-Feng Lin, I-Jen Chiu, Fong-Yu Cheng, Yu-Hsuan Lee, Ying-Jan Wang, Yung-Ho Hsu, Hui-Wen Chiu
BACKGROUND: Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of products, including rubber manufacture, cosmetics, pigments, food additives, medicine, chemical fibers and electronics. However, the molecular mechanisms underlying ZnO NP nephrotoxicity remain unclear. In this study, we evaluated the potential toxicity of ZnO NPs in kidney cells in vitro and in vivo. RESULTS: We found that ZnO NPs were apparently engulfed by the HEK-293 human embryonic kidney cells and then induced reactive oxygen species (ROS) generation...
September 27, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27651323/erdosteine-reduces-the-exercise-induced-oxidative-stress-in-patients-with-severe-copd-results-of-a-placebo-controlled-trial
#13
Roberto W Dal Negro, Maria Visconti
BACKGROUND: Erdosteine (ER), a multimechanism, mucoactive agent with anti-oxidant and anti-inflammatory properties, has been shown to improve lung function, decrease plasma reactive oxygen species (ROS), and 8-isoprostane levels in patients with chronic obstructive pulmonary disease (COPD). AIM: To assess vs. placebo the effect of ER on the exercise-induced oxidative stress by measuring and comparing the release of pro-inflammatory mediators in severe COPD patients...
September 17, 2016: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27645696/obesity-exacerbates-sepsis-induced-oxidative-damage-in-organs
#14
Fabricia Petronilho, Amanda Della Giustina, Diego Zapelini Nascimento, Graciela Freitas Zarbato, Andriele Aparecida Vieira, Drielly Florentino, Lucinéia Gainski Danielski, Mariana Pereira Goldim, Gislaine Tezza Rezin, Tatiana Barichello
Sepsis progression is linked to the imbalance between reactive oxygen species and antioxidant enzymes. Sepsis affects multiple organs, but when associated with a chronic inflammatory disease, such as obesity, it may be exacerbated. We hypothesized that obesity could aggravate the oxidative damage to peripheral organs of rats submitted to an animal model of sepsis. Male Wistar rats aged 8 weeks received hypercaloric nutrition for 2 months to induce obesity. Sepsis was induced by cecal ligation and puncture (CLP) procedure, and sham-operated rats were considered as control group...
December 2016: Inflammation
https://www.readbyqxmd.com/read/27645688/hypoxic-pulmonary-vasoconstriction-from-molecular-mechanisms-to-medicine
#15
Kimberly J Dunham-Snary, Danchen Wu, Edward A Sykes, Amar Thakrar, Leah Rg Parlow, Jeffrey D Mewburn, Joel L Parlow, Stephen L Archer
Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia, diverting blood to better-oxygenated lung segments, thereby optimizing ventilation-perfusion matching and systemic oxygen delivery. In response to alveolar hypoxia, a mitochondrial sensor dynamically changes reactive oxygen species and redox couples in PASMC. This inhibits potassium channels, depolarizes PASMC, activates voltage-gated calcium channels, and increases cytosolic calcium, causing vasoconstriction...
September 16, 2016: Chest
https://www.readbyqxmd.com/read/27613696/niclosamide-prevents-systemic-sclerosis-in-a-reactive-oxygen-species-induced-mouse-model
#16
Florence Morin, Niloufar Kavian, Carole Nicco, Olivier Cerles, Christiane Chéreau, Frédéric Batteux
Systemic sclerosis (SSc) is a connective tissue disorder characterized by fibrosis of the skin and inner organs, vasculopathy, and immunological abnormalities. Recent insights on the implication of STAT3, AKT, and Wnt/β-catenin in fibrosis have prompted us to investigate, in a mouse model of ROS-induced SSc, the effects of niclosamide, an antihelmintic drug that inhibits both of these signaling pathways. SSc was induced in BALB/c mice by daily s.c. injections of hypochlorous acid (HOCl). Mice were treated or not every other day, 5 d a week, for 6 wk, by niclosamide...
September 9, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27611345/elevated-exhalation-of-hydrogen-peroxide-in-patients-with-non-small-cell-lung-cancer-is-not-affected-by-chemotherapy
#17
Agnieszka Krawczyk, Dariusz Nowak, Piotr Jan Nowak, Gianluca Padula, Sylwia Kwiatkowska
OBJECTIVES: Reactive oxygen species, which are implicated in the process of carcinogenesis, are also responsible for cell death during chemotherapy (CHT). Therefore, the aim of the study was to evaluate exhaled H2O2 levels in non-small cell lung cancer (NSCLC) patients before and after CHT. METHODS: Thirty patients (age 61.3 ± 9.3 years) with advanced NSCLC (stage IIIB-IV) and 15 age-matched healthy cigarette smokers were enrolled into the study. Patients received four cycles of cisplatin or carboplatin with vinorelbine every three weeks...
September 9, 2016: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/27611309/cigarette-smoking-condensate-disrupts-endoplasmic-reticulum-golgi-network-homeostasis-through-golph3-expression-in-normal-lung-epithelial-cells
#18
Kyeong-Nam Yu, Hyeon-Jeong Kim, Sanghwa Kim, Orkhouselenge Dawaadamdin, Ah-Young Lee, Sung-Ho Hong, Seung-Hee Chang, Seong-Jin Choi, Soon-Mi Shim, Kyuhong Lee, Myung-Haing Cho
INTRODUCTION: Cigarette smoke (CS) is associated with a broad range of diseases including lung cancer. Many researchers have suggested that cigarette smoke condensate (CSC) may be more toxic compared to cigarette smoke extract (CSE) because CSC contains the lipid-soluble faction of smoke while CSE contains the hydrophilic or gas phase. The aim of this research is to investigate the effects of CSC on the disruption of endoplasmic reticulum (ER)-Golgi homeostasis in normal lung epithelial cells...
September 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27561233/nano-based-rescue-of-dysfunctional-autophagy-in-chronic-obstructive-lung-diseases
#19
Neeraj Vij
INTRODUCTION: ΔF508-CFTR (cystic fibrosis transmembrane conductance regulator) is a common CF-mutation that is known to induce oxidative-inflammatory stress through activation of reactive oxygen species (ROS), which induces autophagy-impairment resulting in accumulation of CFTR in aggresome-bodies. Cysteamine, the reduced form of cystamine, is a FDA-approved drug that has anti-oxidant, anti-bacterial, and mucolytic properties. This drug has been shown in a recent clinical trial to decrease lung inflammation and improve lung function in CF patients by potentially restoring autophagy and allowing CFTR to be trafficked to the cell membrane...
August 26, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27556956/rtp801-amplifies-nox-4-dependent-oxidative-stress-induced-by-cigarette-smoke
#20
Daniel Hernández-Saavedra, Linda Sanders, Mario J Perez, Beata Kosmider, Lynelle P Smith, John D Mitchell, Toshinori Yoshida, Rubin M Tuder
Tobacco smoke (TS) causes chronic obstructive pulmonary disease including, chronic bronchitis, emphysema and asthma. Rtp801, an inhibitor of mTORC1, is induced by oxidative stress triggered by TS. Its upregulation drives lung susceptibility to TS injury by means of enhancing inflammation and alveolar destruction. We postulated that Rtp801 is not only increased by reactive oxygen species (ROS) in TS, but it is instrumental in creating a feedforward process leading to amplification of endogenous ROS generation...
August 24, 2016: American Journal of Respiratory Cell and Molecular Biology
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