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Reactive oxygen species, lung disease

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https://www.readbyqxmd.com/read/29344011/pcb118-induced-cell-proliferation-mediated-by-oxidative-stress-and-mapk-signaling-pathway-in-helf-cells
#1
Muhammad Zaffar Hashmi, Ahmad Hasnain, Jabir Hussain Syed, Muhammad Tariq, Xiaomei Su, Hussani Mubarak, Wajid Nasim, Chaofeng Shen
The present study used human lung fibroblast (HELF) cells as a test model to evaluate the role of oxidative stress (OS) and extracellular signal-regulated kinases 1/2 (ERK1/2) protein in HELF cell proliferation exposed to PCB118. Results from 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide demonstrated that PCB118 at lower concentrations stimulated proliferation of HELF cell and abrogate proliferative effect at higher dose concentrations and in a time-dependent manner. Moreover, reactive oxygen species, malondialdehyde (MDA), and superoxide dismutase showed a significant increase at higher concentrations of PCB118 than the lower concentrations with the passage of time...
January 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29329563/pm2-5-induced-oxidative-stress-increases-intercellular-adhesion-molecule-1-expression-in-lung-epithelial-cells-through-the-il-6-akt-stat3-nf-%C3%AE%C2%BAb-dependent-pathway
#2
Chen-Wei Liu, Tzu-Lin Lee, Yu-Chen Chen, Chan-Jung Liang, Shu-Huei Wang, June-Horng Lue, Jaw-Shiun Tsai, Shih-Wei Lee, Shun-Hua Chen, Yi-Fan Yang, Tzu-Yi Chuang, Yuh-Lien Chen
BACKGROUND: Epidemiological studies have shown that ambient air pollution is closely associated with increased respiratory inflammation and decreased lung function. Particulate matters (PMs) are major components of air pollution that damages lung cells. However, the mechanisms remain to be elucidated. This study examines the effects of PMs on intercellular adhesion molecule-1 (ICAM-1) expression and the related mechanisms in vitro and in vivo. RESULT: The cytotoxicity, reactive oxygen species (ROS) generation, and monocyte adherence to A549 cells were more severely affected by treatment with O-PMs (organic solvent-extractable fraction of SRM1649b) than with W-PMs (water-soluble fraction of SRM1649b)...
January 12, 2018: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29322938/mdd-carb-a-combinatorial-model-for-the-identification-of-protein-carbonylation-sites-with-substrate-motifs
#3
Hui-Ju Kao, Shun-Long Weng, Kai-Yao Huang, Fergie Joanda Kaunang, Justin Bo-Kai Hsu, Chien-Hsun Huang, Tzong-Yi Lee
BACKGROUND: Carbonylation, which takes place through oxidation of reactive oxygen species (ROS) on specific residues, is an irreversibly oxidative modification of proteins. It has been reported that the carbonylation is related to a number of metabolic or aging diseases including diabetes, chronic lung disease, Parkinson's disease, and Alzheimer's disease. Due to the lack of computational methods dedicated to exploring motif signatures of protein carbonylation sites, we were motivated to exploit an iterative statistical method to characterize and identify carbonylated sites with motif signatures...
December 21, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/29318096/a-two-photon-ratiometric-fluorescent-probe-for-imaging-of-hydrogen-peroxide-levels-in-rat-organ-tissues
#4
Chang Su Lim, Myoung Ki Cho, Mi Yeon Park, Hwan Myung Kim
Hydrogen peroxide (H2O2) is important in the regulation of a variety of biological processes and is involved in various diseases. Quantitative measurement of H2O2 levels at the subcellular level is important for understanding its positive and negative effects on biological processes. Herein, a two-photon ratiometric fluorescent probe (SHP-Cyto) with a boronate-based carbamate leaving group as the H2O2 reactive trigger and 6-(benzo[d]thiazol-2'-yl)-2-(N,N-dimethylamino) naphthalene (BTDAN) as the fluorophore was synthesized and examined for its ability to detect cytosolic H2O2 in situ...
January 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29311495/fluorescent-imaging-analysis-for-distribution-of-fluorescent-dye-labeled-or-encapsulated-liposome-in-monocrotaline-induced-pulmonary-hypertension-model-rat
#5
Yo Muraki, Midori Yamasaki, Hirohisa Takeuchi, Kimio Tohyama, Noriyasu Sano, Takanori Matsuo
Pulmonary hypertension (PH) is a life-threatening lung disease. Despite the availability of several approved drugs, the development of a new treatment method is needed because of poor prognosis. Tissue selective drug delivery systems can avoid the adverse effects of current therapy and enhance efficacy. We evaluated the possibility of delivering drugs to the lungs of a PH rat model using fluorescence dye-labeled nanosized liposomes. To evaluate the tissue distribution following systemic exposure, fluorescent dye-labeled, 40-180 nm liposomes with and without polyethylene glycol (PEG) were intravenously administered to a monocrotaline-induced PH (MCT) rat model and tissue fluorescence was measured...
January 6, 2018: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29308441/oxidative-stress-in-the-lung-the-essential-paradox
#6
Lynette K Rogers, Mary J Cismowski
As eukaryotic life evolved, so too did the need for a source of energy that meets the requirements of complex organisms. Oxygen provides this vast potential energy source, but the same chemical reactivity which provides this potential also can have detrimental effects. The lung evolved as an organ that can efficiently promote gas exchange for the entire organism but as such, the lung is highly susceptible to its external environment. Oxygen can be transformed through both enzymatic and non-enzymatic processes into reactive oxygen species (ROS) and reactive nitrogen species (RNS), which can lead to protein, lipid, and DNA damage...
February 2018: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/29306869/biological-responses-to-asbestos-inhalation-and-pathogenesis-of-asbestos-related-benign-and-malignant-disease
#7
Eduardo Solbes, Richart W Harper
Asbestos comprises a group of fibrous minerals that are naturally occurring in the environment. Because of its natural properties, asbestos gained popularity for commercial applications in the late 19th century and was used throughout the majority of the 20th century, with predominant use in the construction, automotive, and shipbuilding industries. Asbestos has been linked to a spectrum of pulmonary diseases, such as pleural fibrosis and plaques, asbestosis, benign asbestos pleural effusion, small cell lung carcinoma, non-small cell lung carcinoma, and malignant mesothelioma...
January 6, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29284777/assessment-of-the-effect-of-wave-device-application-on-morphological-changes-in-organs-and-cells-of-irradiated-animals
#8
V Bebeshko, I Homolyako, V Grynchyshyn
AIM: To study the effect of the Device for wave influence on biological objects on the prevention of the development of acute radiation sickness and chronic radiation syndrome in vivo. MATERIALS AND METHODS: The studies were performed on white rats irradiated at a dose of 8 Gy. The experimental group of irradiated rats was treated with a wave Device (Patent of Ukraine No. 53568) once, for 2.5 min, 1.5 h after irradiation. Their organs were processed by standard histologic methods...
December 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29278451/mir-128-regulates-genes-associated-with-inflammation-and-fibrosis-of-rat-kidney-cells-in-vitro
#9
Sukanya Shyamasundar, Cynthia Ong, Lin-Yue Lanry Yung, S Thameem Dheen, Boon Huat Bay
microRNAs (miRNAs) regulate diverse cellular functions and signaling pathways via inhibiting the expression of their target genes. Given that miR-128 mediates Mitogen-Activated Protein Kinase signaling and production of reactive oxygen species and pro-inflammatory chemokines in various types of cells and tissues, and that miR-128 is differentially expressed in aged and diseased kidneys, we hypothesized that miR-128 may play key roles in kidney inflammation. Hence, in this study, we evaluated the biological effects of miR-128 in normal rat kidney (NRK) cells in vitro...
December 26, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29277898/glucose-6-phosphate-dehydrogenase-inhibition-attenuates-acute-lung-injury-through-reduction-in-nadph-oxidase-derived-reactive-oxygen-species
#10
Ahmed Nadeem, Naif O Al-Harbi, Sheikh F Ahmad, Khalid E Ibrahim, Nahid Siddiqui, Mohammed M Al-Harbi
Acute lung injury (ALI) is a heterogeneous disease with the hallmarks of alveolar capillary membrane injury, increased pulmonary edema and pulmonary inflammation. The commonest direct etiological factor for ALI is usually parenchymal lung infection or hemorrhage. Reactive oxygen species (ROS) generated by NADPH oxidase (NOX2) are thought to play an important role in the pathophysiology of ALI. Glucose-6-phosphate dehydrogenase (G6PD) plays an important role both in production of ROS as well as their removal through supply of NADPH...
December 25, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29246951/metformin-mediates-protection-against-legionella-pneumonia-through-activation-of-ampk-and-mitochondrial-reactive-oxygen-species
#11
Chiaki Kajiwara, Yu Kusaka, Soichiro Kimura, Tetsuo Yamaguchi, Yuta Nanjo, Yoshikazu Ishii, Heiichiro Udono, Theodore J Standiford, Kazuhiro Tateda
In Legionella pneumophila infection, macrophages play a critical role in the host defense response. Metformin, an oral drug for type 2 diabetes, is attracting attention as a new supportive therapy against a variety of diseases, such as cancer and infectious diseases. The novel mechanisms for metformin actions include modulation of the effector functions of macrophages and other host immune cells. In this study, we have examined the effects of metformin on L. pneumophila infection in vitro and in vivo. Metformin treatment suppressed growth of L...
December 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29245060/activation-of-human-eosinophils-with-palladium-nanoparticles-pd-nps-importance-of-the-actin-cytoskeleton-in-pd-nps-induced-cellular-adhesion
#12
P Chhay, M Murphy-Marion, Y Samson, D Girard
Palladium (Pd) is known to be released into the environment in the fine and ultrafine (at the nanoscale) airborne particle fractions mainly from automobile catalytic converters leading to an increase human exposure to this noble metal. It was reported that Pd can induce allergic reactions in individuals exposed to it via different ways. Some studies reported an increased number of eosinophils into airways following NP exposure in vivo in rodent models of allergies and inflammation. Knowing the importance of eosinophils in allergies, asthma and other lung diseases, it is surprising to observe that the direct effect of Pd at the nanoscale in eosinophils has been poorly documented...
December 11, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29240674/evaluation-of-the-cytotoxicity-and-genotoxicity-of-flavonolignans-in-different-cellular-models
#13
Michal Bijak, Ewelina Synowiec, Przemyslaw Sitarek, Tomasz Sliwiński, Joanna Saluk-Bijak
Flavonolignans are the main components of silymarin, which represents 1.5-3% of the dry fruit weight of Milk thistle (Silybum marianum L. Gaernt.). In ancient Greece and Romania, physicians and herbalists used the Silybum marianum to treat a range of liver diseases. Besides their hepatoprotective action, silymarin flavonolignans have many other healthy properties, such as anti-platelet and anti-inflammatory actions. The aim of this study was to evaluate the toxic effect of flavonolignans on blood platelets, peripheral blood mononuclear cells (PBMCs) and human lung cancer cell line-A549-using different molecular techniques...
December 14, 2017: Nutrients
https://www.readbyqxmd.com/read/29230220/induction-of-human-lung-mast-cell-apoptosis-by-granule-permeabilization-a-novel-approach-for-targeting-mast-cells
#14
Aida Paivandy, Martin Sandelin, Helena Igelström, Per Landelius, Christer Janson, Fabio R Melo, Gunnar Pejler
Mast cells are implicated as detrimental players in inflammatory lung diseases, particularly asthma. Mast cells respond to activating stimuli by releasing a wide panel of pro-inflammatory compounds that can contribute profoundly to the pathology, and there is currently an unmet need for strategies that efficiently ameliorate harmful effects of mast cells under such conditions. Here, we sought to evaluate a novel concept for targeting human lung mast cells, by assessing the possibility of selectively depleting the lung mast cells by induction of apoptosis...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29218013/lung-oxidative-stress-dna-damage-apoptosis-and-fibrosis-in-adenine-induced-chronic-kidney-disease-in-mice
#15
Abderrahim Nemmar, Turan Karaca, Sumaya Beegam, Priya Yuvaraju, Javed Yasin, Badreldin H Ali
It is well-established that there is a crosstalk between the lung and the kidney, and several studies have reported association between chronic kidney disease (CKD) and pulmonary pathophysiological changes. Experimentally, CKD can be caused in mice by dietary intake of adenine. Nevertheless, the consequence of such intervention on the lung received only scant attention. Here, we assessed the pulmonary effects of adenine (0.2% w/w in feed for 4 weeks)-induced CKD in mice by assessing various physiological histological and biochemical endpoints...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29203210/indoxyl-sulfate-upregulates-the-cannabinoid-type-1-receptor-gene-via-an-atf3-c-jun-complex-mediated-signaling-pathway-in-the-model-of-uremic-cardiomyopathy
#16
Yu-Juei Hsu, Shih-Che Hsu, Yung-Lung Chang, Shih-Ming Huang, Chun-Che Shih, Chien-Sung Tsai, Chih-Yuan Lin
BACKGROUND: The risk of cardiovascular disease is notably increased in patients with chronic kidney disease (CKD) and cannabinoid receptor type 1 (CB1R) plays an important role in the development of uremic cardiomyopathy. However, the molecular mechanism underlying the uremic toxin-induced upregulation of CB1R remains elusive. METHODS: The expression of the ATF3/c-Jun complex and CB1R in both in vivo and in vitro models of CKD were measured. We also determined the impact of the ATF3/c-Jun complex on CB1R expression by transfecting H9c2 cells with dominant negative mutants of ATF3 or c-Jun...
December 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/29183009/hypoxia-induced-mesenchymal-stromal-cells-exhibit-an-enhanced-therapeutic-effect-on-radiation-induced-lung-injury-in-mice-due-to-an-increased-proliferation-potential-and-enhanced-antioxidant-ability
#17
Bailong Li, Cheng Li, Mo Zhu, Youjun Zhang, Jicong Du, Yang Xu, Bin Liu, Fu Gao, Hu Liu, Jianming Cai, Yanyong Yang
BACKGROUND/AIMS: Radiation therapy is an important treatment for thoracic cancer; however, side effects accompanied with radiotherapy lead to limited tumor control and a decline in patient quality of life. Among these side effects, radiation-induced lung injury (RILI) is the most serious and common. Hence, an effective remedy for RILI is needed. Mesenchymal stromal cells (MSCs) are multipotent adult stem cells that have been demonstrated to be an effective treatment in some disease caused by tissue damage...
November 29, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29178078/epithelial-mitochondrial-dysfunction-in-lung-disease
#18
Linlin Zhang, William Wang, Bijun Zhu, Xiangdong Wang
Since the twentieth century, scientists have studied the functions and mechanisms of the mitochondria. The mitochondrion plays many important roles in cell functioning and contributes to apoptosis, embryonic and tissue development, aging, etc. Consequently, mitochondrial dysfunction often has a direct impact on health such as aging, tumorigenesis, lung injury and COPD, etc. Recent evidence indicates that the mitochondria could also be a crucial contributor to immunity with functions such as biogenesis, fusion, and fission impacting various areas in initializing immunity...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29174587/effects-of-mesenchymal-stromal-cells-play-a-role-the-oxidant-antioxidant-balance-in-a-murine-model-of-asthma
#19
M A S Malaquias, L A Oyama, P C Jericó, I Costa, G Padilha, S Nagashima, M Lopes-Pacheco, C L K Rebelatto, P V Michelotto, D G Xisto, P R S Brofman, P R M Rocco, L de Noronha
Asthma is a heterogeneous disease characterised by chronic airway inflammation. One of the most devastating consequences of this inflammatory process is the generation of reactive oxygen and nitrogen species responsible for oxidative stress. The aim of this study is to analyse the efficiency of treatment with human bone marrow-derived mesenchymal stromal cells (hMSC) in maintaining the oxidative balance in a murine model of allergic asthma by quantifying nitrotyrosine in lung tissues. After confirmation of asthma in the experimental model, samples of lung parenchyma were submitted to immunohistochemical assessment...
November 23, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29172151/oxidative-stress-driven-pulmonary-inflammation-and-fibrosis-in-a-mouse-model-of-human-ataxia-telangiectasia
#20
Ruth Duecker, Patrick Baer, Olaf Eickmeier, Maja Strecker, Jennifer Kurz, Alexander Schaible, Dirk Henrich, Stefan Zielen, Ralf Schubert
Lung failure is responsible for significant morbidity and is a frequent cause of death in ataxia-telangiectasia (A-T). Disturbance in the redox balance of alveolar epithelial cells must be considered as a causal factor for respiratory disease in A-T. To investigate bronchoalveolar sensitivity to reactive oxygen species (ROS) and ROS-induced DNA damage, we used bleomycin (BLM) to induce experimental inflammation and fibrotic changes in the Atm-deficient mouse model. BLM or saline was administered by oropharyngeal instillation into the lung of Atm-deficient mice and wild-type mice...
November 10, 2017: Redox Biology
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