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https://www.readbyqxmd.com/read/28323047/biochemical-and-chemical-characterization-of-cynara-cardunculus-l-extract-and-its-potential-use-as-co-adjuvant-therapy-of-chronic-myeloid-leukemia
#1
Antonio Russo, Mariarita Perri, Erika Cione, Maria Luisa Di Gioia, Monica Nardi, Maria Cristina Caroleo
ETHNOPHARMACOLOGICAL RELEVANCE: Ancient mediterranean diet was characterized by consuming the spontaneous forms of Cynara Cardunculus L. (CCL), commonly called artichoke. Cultivated and/or spontaneous forms of CC studies have demonstrated that methanol extract of CCL flower and/or cynaropicrin showed remarkable anti-proliferative activity in vitro models of leukocyte cancer cell. AIM OF THE STUDY: Chronic myeloid leukemia (CML) is associated with a reciprocal translocation of the long arms of chromosomes 9 and 22 generating the BCR/ABL fusion gene, translated in the p210(BCR/ABL) oncoprotein kinase...
March 18, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28301568/toxicity-of-spinosad-to-temephos-resistant-aedes-aegypti-populations-in-brazil
#2
Luciana Dos Santos Dias, Maria de Lourdes da Graça Macoris, Maria Teresa Macoris Andrighetti, Vanessa Camargo Garbeloto Otrera, Adriana Dos Santos Dias, Luiz Guilherme Soares da Rocha Bauzer, Cynara de Melo Rodovalho, Ademir Jesus Martins, José Bento Pereira Lima
The mosquito Aedes aegypti is the primary vector of different arboviruses and represents a major public health problem. Several Brazilian populations of Ae. aegypti have developed resistance to temephos, the most used organophosphate larvicide. New tools which are less harmful to the environment and safer for humans are becoming increasingly important to control this insect vector. Spinosad, an aerobic fermentation product of a soil actinobacteria, has a favorable environmental profile. It presents selective insecticide properties, a mechanism of action that differs from those of many synthetic chemical insecticides...
2017: PloS One
https://www.readbyqxmd.com/read/28288419/the-potential-of-native-species-as-bioenergy-crops-on-trace-element-contaminated-mediterranean-lands
#3
María T Domínguez, María M Montiel-Rozas, Paula Madejón, Manuel J Diaz, Engracia Madejón
The establishment of energy crops could be an option for the management of degraded and contaminated lands, where they would not compete with food production for land use. Here, we aimed to explore the potential of certain native Mediterranean species for the revegetation of contaminated lands for energy production purposes. A field survey was conducted in a trace-element (TE) contaminated area from SW Spain, where the patterns of biomass production, TE accumulation and the calorific value of some thistle species were analyzed along a soil contamination gradient...
March 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28274427/determination-of-pesticide-residues-in-globe-artichoke-leaves-and-fruits-by-gc-ms-and-lc-ms-ms-using-the-same-quechers-procedure
#4
Ignacio Machado, Natalia Gérez, Mariela Pistón, Horacio Heinzen, María Verónica Cesio
Aiming to select the most suitable sample preparation for the multiresidue analysis of pesticides in globe artichoke (Cynara cardunculus L.), a modified QuEChERS, a matrix solid phase dispersion and a dispersive ethyl acetate extraction were compared. Trueness and precision were determined at 0.2mgkg(-1) for the three methods. The modified QuEChERS showed the best performance. The scope of the method was enlarged to 35 GC and 63 LC amenable pesticides, its overall performance was evaluated and validated to artichoke leaves and fruits according to DG-SANTE Guidelines...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28251314/molecular-diagnosis-of-acanthamoeba-keratitis-evaluation-in-rat-model-and-application-in-suspected-human-cases
#5
Adriana Oliveira Costa, Cinthia Furst, Lucas Oliveira Rocha, Cecília Cirelli, Carolina Neris Cardoso, Fagner Salmazo Neiva, Cynara Oliveira Possamai, Daniel de Assis Santos, Vanete Thomaz-Soccol
Acanthamoeba keratitis (AK) is a progressive corneal infection that demands rapid and sensitive techniques for diagnosis to avoid risk of visual impairment. We evaluated two DNA extraction techniques and a semi-nested-PCR (snPCR) targeting the 18S rRNA gene to detect Acanthamoeba cysts and trophozoites. The most effective protocol was evaluated in samples of corneal scrapings and biopsies from an AK rat model and applied to diagnosis of human cases of AK. DNA extraction performed with a commercial kit based on DNA binding to magnetic beads was more efficient than a method based on alkaline lysis, allowing the detection of one trophozoite and one cyst of Acanthamoeba in samples prepared from cultures...
March 1, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28212860/comparative-structure-function-characterization-of-the-saposin-like-domains-from-potato-barley-cardoon-and-arabidopsis-aspartic-proteases
#6
Brian C Bryksa, Douglas A Grahame, Rickey Y Yada
The present study characterized the aspartic protease saposin-like domains of four plant species, Solanum tuberosum (potato), Hordeum vulgare L. (barley), Cynara cardunculus L. (cardoon; artichoke thistle) and Arabidopsis thaliana, in terms of bilayer disruption and fusion, and structure pH-dependence. Comparison of the recombinant saposin-like domains revealed that each induced leakage of bilayer vesicles composed of a simple phospholipid mixture with relative rates Arabidopsis>barley>cardoon>potato...
February 16, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28212611/impact-of-novel-snps-identified-in-cynara-cardunculus-genes-on-functionality-of-proteins-regulating-phenylpropanoid-pathway-and-their-association-with-biological-activities
#7
Ana Margarida Ferro, Patrícia Ramos, Olinda Guerreiro, Eliana Jerónimo, Inês Pires, Carmen Capel, Juan Capel, Rafael Lozano, Maria F Duarte, M Margarida Oliveira, Sónia Gonçalves
BACKGROUND: Cynara cardunculus L. offers a natural source of phenolic compounds with the predominant molecule being chlorogenic acid. Chlorogenic acid is gaining interest due to its involvement in various biological properties such as, antibacterial, antifungal, antioxidant, hepatoprotective, and anticarcinogenic activities. RESULTS: In this work we screened a Cynara cardunculus collection for new allelic variants in key genes involved in the chlorogenic acid biosynthesis pathway...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28193423/effect-of-extraction-ph-on-techno-functional-properties-of-crude-extracts-from-wild-cardoon-cynara-cardunculus-l-flowers
#8
Amal Ben Amira, Ines Makhlouf, Raul Flaviu Petrut, Frédéric Francis, Julien Bauwens, Hamadi Attia, Souhail Besbes, Christophe Blecker
In the present paper, techno-functional properties of rennet derived from C. cardunculus, prepared at various pH (from 3 to 6), were investigated. It was found that the extract prepared at pH 3 had the best milk-clotting properties (MCA/PA ratio). It presented also the highest enzyme content, determined by densitometry analysis on 1D and 2D gels electrophoresis. Formation of milk gels produced by the extracts and chymosin was monitored using dynamic rheology and turbiscan. It can be assumed that by lowering rennet pH, milk pH decreases, causing a significant increase of curd firmness and both elastic (G') and viscous (G″) moduli...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28147701/genotoxic-and-chemopreventive-assessment-of-cynara-scolymus-l-aqueous-extract-in-a-human-derived-liver-cell-line
#9
Regiane Pereira da Silva, Laura Vicedo Jacociunas, Raíne Fogliati de Carli, Bianca Regina Ribas de Abreu, Mauricio Lehmann, Juliana da Silva, Alexandre de Barros Falcão Ferraz, Rafael Rodrigues Dihl
Cynara scolymus L., popularly known as artichoke, is consumed as food and used as tea infusions for pharmacological purposes to treat liver dysfunctions and other conditions. Scientific data on the safety and protective effect of artichoke in human-derived liver cells is missing. This study investigated the genotoxic and modulatory effect of a liophilized extract suspended in water of C. scolymus L. leaves. Four extract concentrations (0.62, 1.25, 2.5 and 5.0 mg/mL) were evaluated using the comet assay on human hepatocyte cultures, HepG2 cells...
February 1, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/28103294/community-based-entomological-surveillance-reveals-urban-foci-of-chagas-disease-vectors-in-sobral-state-of-cear%C3%A3-northeastern-brazil
#10
Cynara Carvalho Parente, Fernando S M Bezerra, Plutarco I Parente, Raimundo V Dias-Neto, Samanta C C Xavier, Alberto N Ramos, Filipe A Carvalho-Costa, Marli M Lima
BACKGROUND: The aim of this work was to explore the potential risk of vector-borne Chagas disease in urban districts in northeastern Brazil, by analyzing the spatiotemporal distributions and natural infection rates with Trypanosoma cruzi of triatomine species captured in recent years. The main motivation of this work was an acute human case of Chagas disease reported in 2008 in the municipality of Sobral. METHODOLOGY/PRINCIPAL FINDINGS: We analyzed data from community-based entomological surveillance carried out from 2010 to 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28101252/identification-of-proteins-from-wild-cardoon-flowers-cynara-cardunculus-l-by-a-proteomic-approach
#11
Amal Ben Amira, Julien Bauwens, Edwin De Pauw, Souhail Besbes, Hamadi Attia, Frédéric Francis, Christophe Blecker
Proteomic approach was applied to identify total proteins, particularly the enzymatic content, from wild cardoon flowers. As the selection of an appropriate sample preparation method is the key for getting reliable results, two different extraction/precipitation methods (trichloroacetic acid and phenol/ammonium acetate) were tested on fresh and lyophilized flowers. After two-dimensional electrophoresis (2D-E) separations, a better protein pattern was obtained after phenol extraction from lyophilized flowers...
January 2017: Journal of Chemical Biology
https://www.readbyqxmd.com/read/28036090/antiproliferative-effects-of-cynara-cardunculus-l-var-altilis-dc-lipophilic-extracts
#12
Patrícia A B Ramos, Ângela R Guerra, Olinda Guerreiro, Sónia A O Santos, Helena Oliveira, Carmen S R Freire, Armando J D Silvestre, Maria F Duarte
Besides being traditionally used to relieve hepatobiliary disorders, Cynara cardunculus L. has evidenced anticancer potential on triple-negative breast cancer (TNBC). This study highlights the antiproliferative effects of lipophilic extracts from C. cardunculus L. var. altilis (DC) leaves and florets, and of their major compounds, namely cynaropicrin and taraxasteryl acetate, against MDA-MB-231 cells. Our results demonstrated that MDA-MB-231 cells were much less resistant to leaves extract (IC50 10.39 µg/mL) than to florets extract (IC50 315...
December 29, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27976109/agrimonia-eupatoria-and-cynara-cardunculus-water-infusions-influence-on-selected-parameters-in-streptozotocin-induced-diabetic-rats
#13
P Mučaji, A Kuczmannová, P Gál, A Balažová, E Račanská, M Kameníková, S Fialová, M Nagy
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975443/anti-mesothelioma-mechanism-of-action-studies-of-a-complex-cynara-scolymus-fraction-using-in-silico-target-prediction-and-gene-expression-profiling
#14
N Sharma, C Pulito, G Klambauer, L Mattoli, S Strano, G Blandino, J Lucci, A Bender
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27968988/spatial-genetic-structure-in-wild-cardoon-the-ancestor-of-cultivated-globe-artichoke-limited-gene-flow-fragmentation-and-population-history
#15
D Rau, M Rodriguez, E Rapposelli, M L Murgia, R Papa, A H D Brown, G Attene
Nuclear and chloroplast markers and phenotypic characters were integrated to analyse the population genetic structure of wild cardoon, Cynara cardunculus var. sylvestris, the ancestor of cultivated globe artichoke, Cynara cardunculus var. scolymus on the island of Sardinia, Italy. The spatial scale ranged from a few metres to ∼200km. Wild cardoon appears to be genetically fragmented, with significant genetic divergence at various scales, indicating that gene flow is insufficient to counterbalance the effects of genetic drift or founder effects...
December 2016: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/27830052/first-detailed-karyo-morphological-analysis-and-molecular-cytological-study-of-leafy-cardoon-and-globe-artichoke-two-multi-use-asteraceae-crops
#16
Debora Giorgi, Gianmarco Pandozy, Anna Farina, Valentina Grosso, Sergio Lucretti, Andrea Gennaro, Paola Crinò, Francesco Saccardo
Traditionally globe artichoke and leafy cardoon have been cultivated for use as vegetables but these crops are now finding multiple new roles in applications ranging from paper production to cheese preparation and biofuel use, with interest in their functional food potential. So far, their chromosome complements have been poorly investigated and a well-defined karyotype was not available. In this paper, a detailed karyo-morphological analysis and molecular cytogenetic studies were conducted on globe artichoke (Cynara cardunculus Linnaeus, 1753 var...
2016: Comparative Cytogenetics
https://www.readbyqxmd.com/read/27765213/influence-of-ph-on-viscoelastic-properties-of-heat-induced-gels-obtained-with-a-%C3%AE-lactoglobulin-fraction-isolated-from-bovine-milk-whey-hydrolysates
#17
Natalia Estévez, Pablo Fuciños, Verónica Bargiela, Guillermo Picó, Nadia Woitovich Valetti, Clara Asunción Tovar, M Luisa Rúa
A β-Lactoglobulin fraction (r-βLg) was isolated from whey hydrolysates produced with cardosins from Cynara cardunculus. The impact of the hydrolysis process on the r-βLg structure and the rheological properties of heat-induced gels obtained thereafter were studied at different pH values. Differences were observed between r-βLg and commercial β-Lg used as control. Higher values for the fluorescence emission intensity and red shifts of the emission wavelength of r-βLg suggested changes in its tertiary structure and more solvent-exposed tryptophan residues...
March 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27765051/wild-food-plants-and-minor-crops-in-the-ripoll%C3%A3-s-district-catalonia-iberian-peninsula-potentialities-for-developing-a-local-production-consumption-and-exchange-program
#18
Montse Rigat, Airy Gras, Ugo D'Ambrosio, Teresa Garnatje, Montse Parada, Joan Vallès
BACKGROUND: Wild food plants (WFP) have always been consumed by humans, first as the main basis of their food and, since the origins of agriculture, as ingredients of normal diets or as an alternative during situations of scarcity. In contemporary industrialized societies their use is for the most part being abandoned, but they may still play an important role. With the purpose of advancing in the ethnobotanical knowledge of one region of the Catalan Pyrenees, the present study reports the findings of a research project conducted in the Ripollès district (Catalonia, Iberian Peninsula), concerning ethnobotanical knowledge and use of wild and semi-wild vascular plants as foods, along with minor crops...
October 20, 2016: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/27735918/-nonalcoholic-steatohepatitis-and-biliary-sludge-in-people-with-metabolic-syndrome
#19
V G Radchenko, P V Seliverstov, S S Ledentsova, A V Man'yakov
AIM: To determine the incidence of biliary sludge (BS) and to evaluate the clinical efficacy of Chophytol in patients with nonalcoholic steatohepatitis (NASH) and BS in the presence of metabolic syndrome (MS). SUBJECTS AND METHODS: Clinical laboratory examination was made in 72 patients with NASH in the presence of MS. BS was identified in 52 (72.2%) examinees who were divided in two (study and control) groups. The efficacy of Chophytol of plant origin, prepared from the purified extract of fresh artichoke (Cynara scolymus) leaf juice, which was used at a dose of 3 tablets thrice daily for a month, was evaluated...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27723561/in-silico-approaches-and-proportional-odds-model-towards-identifying-selective-adam17-inhibitors-from-anti-inflammatory-natural-molecules
#20
Pallab Kumar Borah, Sourav Chakraborty, Anupam N Jha, Sanchaita Rajkhowa, Raj Kumar Duary
ADAM metallopeptidase domain 17 (ADAM17) is an attractive target for the development of new anti-inflammatory drugs. We aimed to identify selective inhibitors of ADAM17 against matrix metalloproteinase enzymes (MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-13, and MMP-16) which have substantial structural similarity. Target proteins were docked with 29 anti-inflammatory natural molecule ligands and a known selective inhibitor IK682. The ligands were screened based on Lipinski rules, interaction with the ADAM17 active site cavity, and then ranked using the proportional odds model multinomial logistic regression...
November 2016: Journal of Molecular Graphics & Modelling
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