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https://www.readbyqxmd.com/read/28926365/primary-cutaneous-diffuse-large-b-cell-lymphoma-leg-type-with-spontaneous-regression-after-biopsy
#1
Gabriel Marrero-Alemán, Társila Montenegro-Dámaso, Yeray Peñate
Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) represents approximately 20% of cutaneous B lymphomas with an intermediate prognosis. Spontaneous regression is uncommon; there are only 2 published cases. An 83-year-old woman presented 2 orange erythematous nodules on the back of her right leg with an elastic consistency, infiltrated, painful to the touch, and of an 8-month evolution. A histological examination revealed a dense cellular dermo-hypodermic infiltrate sparing the papillary dermis, composed of large cells with immunoblast and centroblast morphology and frequent mitosis...
October 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28926201/effect-of-topical-application-of-black-seed-oil-on-imiquimod-induced-psoriasis-like-lesions-in-the-thin-skin-of-adult-male-albino-rats
#2
Ebtsam F Okasha, Naglaa A Bayomy, Eman Z Abdelaziz
Psoriasis is a chronic inflammatory skin disease that affects about 1-3% of the world's population. Black seed oil, i.e the oil extracted from black seeds (Nigella sativa seeds), possesses a broad spectrum of pharmacological actions including anti-inflammatory, immunostimulatory and antioxidant properties. This study aimed to investigate the effect of black seed oil on imiquimod (IMQ) induced psoriasis-like skin lesions. To this end, 30 male albino rats were divided into three groups: group I, control group; group II, psoriasis-induced group receiving daily topical applications of IMQ cream (5%) on the shaved back skin for 10 consecutive days; and group III, black seed oil group receiving a daily topical dose of black seed oil 5 mg/kg body weight for 10 days after induction of psoriasis...
September 19, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28922948/clinical-and-dermoscopic-features-of-pigmented-disseminated-superficial-actinic-porokeratosis-case-report-and-literature-review
#3
Bahman Sotoodian, Muhammad N Mahmood, Thomas G Salopek
INTRODUCTION: Porokeratosis is a benign hyperkeratotic skin tumour due to a clonal proliferation of keratinocytes and is characterised by a telltale annular threadlike configuration along the border of a skin-colored to erythematous papule that can expand centrifugally. CASE PRESENTATION: We are presenting a clinical and dermoscopic case of pigmented disseminated superficial actinic porokeratosis (DSAP) limited to the upper trunk of a white man with sun-damaged skin...
September 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28920799/presumptive-pit-viper-envenomation-in-psittacines-in-a-brazilian-zoo
#4
Mathias Dislich, Peter Wohlsein, Anna Sophie Croukamp, Ulrich Neumann
Snake bites represent a serious public health risk in many regions of the globe, especially in tropical areas. Clinical signs and postmortem changes are well described in human and other mammalian species. However, detailed case reports about venomous snake attacks in avian species are limited. This report describes presumptive fatal envenomations in three psittacines caused by pit vipers in a Brazilian zoo. In one case, a Brazilian lancehead (Bothrops moojeni) was captured in the aviary. In all three cases the dermis around the suspected snake bite area exhibited hemorrhages and edema...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28918228/primary-photosensitization-and-contact-dermatitis-caused-by-malachra-fasciata-jacq-n-v-malvaceae-in-sheep
#5
Valber Onofre de Araújo, Temístocles Soares Oliveira Neto, Sara Vilar Dantas Simões, Thatyana Kelly Ferreira da Silva, Franklin Riet-Correa, Ricardo Barbosa Lucena
Farmers from Paraiba state, Northeast Brazil, claim that Malachra fasciata causes cutaneous lesions in sheep. To test its toxicity the plant was harvested daily and fed ad libitum for 21 days to 3 sheep as the sole food source (# 1-3). An additional sheep (# 4) was maintained as a control. Cutaneous lesions of photosensitization initiated after 7 days and increased continuously over the next 21 days. The dose ingested varied between 129 g/kg to 175 g/kg. Alopecia, hyperemia and crusting were observed in the animals...
September 14, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28916993/periostin-in-the-pathogenesis-of-skin-diseases
#6
REVIEW
Hiroyuki Murota, Yang Lingli, Ichiro Katayama
Skin is an organ that is susceptible to damage by external injury, chronic inflammation, and autoimmunity. Tissue damage causes alterations in both the configuration and type of cells in lesional skin. This phenomenon, called tissue remodeling, is a universal biological response elicited by programmed cell death, inflammation, immune disorders, and tumorigenic, tumor proliferative, and cytoreductive activity. In this process, changes in the components of the extracellular matrix are required to provide an environment that facilitates tissue remodeling...
September 15, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28913291/immediate-near-total-scalp-reconstruction-with-artificial-dermis-on-exposed-calvarium
#7
Sooyeon Park, Ki Taik Han, Min Cheol Kim, Jin Soo Lim
Scalp defect management is complicated secondary to reduced laxity in the scalp and forehead area. For reconstruction of larger defects with exposed bone and loss of the periosteal layer, free flap reconstruction is one option for single-stage surgery, although the procedure is lengthy and includes the possibility of flap loss. We successfully performed a single-stage reconstruction of a large scalp defect using a combination of artificial dermis, split-thickness skin graft, and full-thickness skin graft following wide excision of a cutaneous angiosarcoma, and present our method as one option for the treatment of large oncologic surgical defects in patients who are poor candidates for free flap surgery...
December 2016: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912854/comparative-proteomics-analysis-of-primary-cutaneous-amyloidosis
#8
Daxing Cai, Yang Li, Chunlei Zhou, Yulin Jiang, Jian Jiao, Lin Wu
Primary cutaneous amyloidosis (PCA) is a localized skin disorder that is characterized by the abnormal deposition of amyloid in the extracellular matrix (ECM) of the dermis. The pathogenesis of PCA is poorly understood. The objective of the present study was to survey proteome changes in PCA lesions in order to gain insight into the molecular basis and pathogenesis of PCA. Total protein from PCA lesions and normal skin tissue samples were extracted and analyzed using the isobaric tags for relative and absolute quantitation technique...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28910869/-lymphomatoid-papulosis-a-clinicopathologic-analysis-and-whole-exome-sequencing
#9
T T Wang, Y Xie, L Li, L Wang
Objective: To study the clinicopathologic characteristics and immunophenotype of lymphomatoid papulosis(LyP), followed by exon mutation analysis with focus on gene mutations involved in apoptosis pathway and other possible pathogenic genes. Methods: Clinical data analysis and immunohistochemical staining were carried out in 20 cases of LyP. Whole exome sequencing technology was employed in 2 cases of type C of LyP. Results: Of the 20 cases, there were 9 males and 11 females with a median age of 28.6 years. Nineteen patients presented with multiple papules and nodules, and one case presented with only one tumor nodule...
September 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28903047/caloric-restriction-promotes-structural-and-metabolic-changes-in-the-skin
#10
Maria Fernanda Forni, Julia Peloggia, Tárcio T Braga, Jesús Eduardo Ortega Chinchilla, Jorge Shinohara, Carlos Arturo Navas, Niels Olsen Saraiva Camara, Alicia J Kowaltowski
Caloric restriction (CR) is the most effective intervention known to enhance lifespan, but its effect on the skin is poorly understood. Here, we show that CR mice display fur coat remodeling associated with an expansion of the hair follicle stem cell (HFSC) pool. We also find that the dermal adipocyte depot (dWAT) is underdeveloped in CR animals. The dermal/vennule annulus vasculature is enlarged, and a vascular endothelial growth factor (VEGF) switch and metabolic reprogramming in both the dermis and the epidermis are observed...
September 12, 2017: Cell Reports
https://www.readbyqxmd.com/read/28902090/endocrine-mucin-producing-sweat-gland-carcinoma-of-the-eyelid-associated-with-mucinous-adenocarcinoma
#11
Norman C Charles, Alan D Proia, Christopher Lo
Endocrine mucin-producing sweat gland carcinoma, a rare, low-grade neoplasm with predilection for the eyelids, has been posited as a precursor to invasive mucinous adenocarcinoma. Endocrine mucin-producing sweat gland carcinoma and its concurrence with mucinous adenocarcinoma have received little attention in the ophthalmic literature. The combination of the 2 histologic patterns parallels endocrine ductal carcinoma in situ of the breast and its transition to Type B invasive mucinous carcinoma. The authors describe a 59-year-old man who developed a tumor of the right upper eyelid showing endocrine mucin-producing sweat gland carcinoma in the outer dermis and extensive mucinous carcinoma in the deeper tissue...
September 1, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28901746/a-lab-on-skin-a-review-of-flexible-and-stretchable-electronics-for-wearable-health-monitoring
#12
Yuhao Liu, Matt Pharr, Giovanni Antonio Salvatore
Skin is the largest organ of the human body, and it offers a diagnostic interface rich with vital biological signals from the inner organs, blood vessels, muscles, and dermis/epidermis. Soft, flexible, and stretchable electronic devices provide a novel platform to interface with soft tissues for robotic feedback and control, regenerative medicine, and continuous health monitoring. Here, we introduce the term "lab-on-skin" to describe a set of electronic devices that have physical properties, such as thickness, thermal mass, elastic modulus, and water-vapor permeability, which resemble those of the skin...
September 13, 2017: ACS Nano
https://www.readbyqxmd.com/read/28901561/eosinophils-are-rare-in-biopsy-specimens-of-psoriasis-vulgaris
#13
Gabriela Rosa, Anthony P Fernandez, Sarah Schneider, Steven D Billings
BACKGROUND: Histologic features of lesional biopsies can be helpful in distinguishing psoriasis subtypes from disease mimickers. However, occasionally classic histologic features are not sufficient for distinction and additional clues would be useful. There is a common belief that presence of eosinophils in skin biopsies argues against psoriasis, but actual literature is scant. DESIGN: Skin biopsies from 2013-2016 with a diagnosis of psoriasis were reviewed. For inclusion both histologic and clinical features were required to be consistent with psoriasis...
September 13, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28900691/quantification-of-n-phenyl-2-naphthylamine-by-gas-chromatography-and-isotope-dilution-mass-spectrometry-and-its-percutaneous-absorption-ex-vivo-under-workplace-conditions
#14
Eike Maximilian Marek, Stephan Koslitz, Tobias Weiss, Manigé Fartasch, Gerhard Schlüter, Heiko Udo Käfferlein, Thomas Brüning
N-Phenyl-2-naphthylamine (P2NA) is an antioxidant used to protect rubbers from flex-cracking. P2NA can be converted in vivo to 2NA, one of the most potent bladder carcinogens. Here, we report the specific and ultra-sensitive quantification of P2NA in the receptor fluid of Franz diffusion cells by gas chromatography and isotope-dilution tandem-mass spectroscopy (GC-MS/MS). The experimental conditions were optimized to minimize losses of P2NA due to surface absorption on glass, plastic, and rubber material, and subsequently validated...
September 12, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28895889/the-skin-bacterium-propionibacterium-acnes-employs-two-variants-of-hyaluronate-lyase-with-distinct-properties
#15
Seven Nazipi, Kristian Stødkilde-Jørgensen, Carsten Scavenius, Holger Brüggemann
Hyaluronic acid (HA) and other glycosaminoglycans are extracellular matrix components in the human epidermis and dermis. One of the most prevalent skin microorganisms, Propionibacterium acnes, possesses HA-degrading activity, possibly conferred by the enzyme hyaluronate lyase (HYL). In this study, we identified the HYL of P. acnes and investigated the genotypic and phenotypic characteristics. Investigations include the generation of a P. acneshyl knockout mutant and HYL activity assays to determine the substrate range and formed products...
September 12, 2017: Microorganisms
https://www.readbyqxmd.com/read/28895165/preliminary-results-of-tissue-engineered-injection-laryngoplasty-material-in-a-rabbit-model
#16
Michael S Oldenburg, Dale C Ekbom, Serban San Marina, Steve Voss, Tiffany Chen, Joaquin Garcia, Jeffery R Janus
OBJECTIVES/HYPOTHESIS: Design and test a novel biomaterial for injection laryngoplasty aimed to increase the duration of effectiveness of micronized acellular dermis. STUDY DESIGN: Animal model. METHODS: Injection laryngoplasty was performed in three groups (n = 5) of New Zealand White rabbits. Acellular dermis was either used alone as a control (group 1), was combined with undifferentiated stem cells (group 2), or with predifferentiated chondrocytic cells (group 3)...
September 12, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28894928/enhanced-dendritic-cells-and-regulatory-t-cells-in-the-dermis-of-porokeratosis
#17
Kanako Matsuyama, Yoko Mizutani, Tomoko Takahashi, En Shu, Hiroyuki Kanoh, Tatsuhiko Miyazaki, Mariko Seishima
Porokeratosis is characterized clinically by annular lesions and histologically by the presence of a cornoid lamella (CL) in the epidermis. The underlying mechanism of porokeratosis development remains unclear. We performed immunohistochemical staining of CD1a, langerin, Ki67, CD3, CD4, CD8, FOXP3, and RANKL (receptor activator of nuclear factor κB ligand) in samples from 17 porokeratosis lesions and analyzed the differences in staining patterns among the CL, the inner part of the annular ridge (IC), and the adjacent normal skin (ANS)...
September 11, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28894750/factor-xiii-subunit-a-in-the-skin-applications-in-diagnosis-and-treatment
#18
REVIEW
Lilla Paragh, Daniel Törőcsik
The role of factor XIII subunit A (FXIII-A) is not restricted to hemostasis. FXIII-A is also present intracellularly in several human cells and serves as a diagnostic marker in a wide range of dermatological diseases from inflammatory conditions to malignancies. In this review, we provide a guide on the still controversial interpretation of dermal cell types expressing FXIII-A and assess the previously described mechanisms behind their accumulation under physiological and pathological conditions of the human skin...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28894654/evaluation-of-a-novel-hybrid-viable-bioprosthetic-mesh-in-a-model-of-mesh-infection
#19
Ally Ha, Erik T Criman, Wendy E Kurata, Karen W Matsumoto, Lisa M Pierce
BACKGROUND: The reported incidence of mesh infection in contaminated operative fields is as high as 30% regardless of material used. Our laboratory previously showed that augmenting acellular bioprosthetic mesh with allogeneic mesenchymal stem cells (MSC) enhances resistance to bacterial colonization in vivo and preserves mesh integrity. This study's aim was to determine whether augmentation of non-crosslinked porcine dermis (Strattice) with commercially available, cryopreserved, viable MSC-containing human placental tissue (Stravix) similarly improves infection resistance after inoculation with Escherichia coli (E...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28894365/photothermal-ablation-of-inflammatory-breast-cancer-tumor-emboli-using-plasmonic-gold-nanostars
#20
Bridget M Crawford, Ronnie L Shammas, Andrew M Fales, David A Brown, Scott T Hollenbeck, Tuan Vo-Dinh, Gayathri R Devi
Inflammatory breast cancer (IBC) is rare, but it is the most aggressive subtype of breast cancer. IBC has a unique presentation of diffuse tumor cell clusters called tumor emboli in the dermis of the chest wall that block lymph vessels causing a painful, erythematous, and edematous breast. Lack of effective therapeutic treatments has caused mortality rates of this cancer to reach 20%-30% in case of women with stage III-IV disease. Plasmonic nanoparticles, via photothermal ablation, are emerging as lead candidates in next-generation cancer treatment for site-specific cell death...
2017: International Journal of Nanomedicine
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