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https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#1
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781576/ultrasonography-for-the-assessment-of-skin-in-systemic-sclerosis-a-systematic-review
#2
Tânia Santiago, Mariana Santiago, Barbara Ruaro, Maria João Salvador, Maurizio Cutolo, J A P da Silva
OBJECTIVE: To identify and synthesise the best available evidence on the use of ultrasound to assess skin involvement in systemic sclerosis (SSc). METHODS: We conducted a systemic review of the literature on Pubmed MEDLINE and Embase, using the vocabulary terms: ('systemic sclerosis OR scleroderma') AND ('ultrasonography' OR 'Elasticity Imaging Techniques') AND ('skin' OR 'dermis'). Two independent reviewers selected articles, collected data from studies and carried out a manual search of the references from the studies included...
May 21, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29780912/orbital-implant-exposure-after-acanthamoeba-panophthalmitis
#3
Meredith S Baker, Amanda C Maltry, Nasreen A Syed, Richard C Allen
Purpose: Acanthamoeba is a protozoa that can lead to severe ocular disease and sequelae. Although intraocular Acanthamoeba infection is rare, the following case demonstrates an unusual presentation of recurrent Acanthamoeba infection in a 30 year old contact lens wearing male. Observations: After presenting with recurrent Acanthamoeba keratitis and undergoing various treatments, the patient developed nodular scleritis, which evolved into panophthalmitis, and ultimately, required enucleation...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29777504/implementation-and-validation-of-constitutive-relations-for-human-dermis-mechanical-response
#4
Alessandra Aldieri, Mara Terzini, Cristina Bignardi, Elisabetta M Zanetti, Alberto L Audenino
Finite element models in conjunction with adequate constitutive relations are pivotal in several physiological and medical applications related to both native and engineered tissues, allowing to predict the tissue response under various loading states. In order to get reliable results, however, the validation of the constitutive models is crucial. Therefore, the main purpose of this work is to provide an experimental-computational approach to the biomechanical investigation of soft tissues such as the dermis...
May 19, 2018: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29774573/multiple-acquired-smooth-muscle-hamartomas-with-2-different-muscle-components-on-scalp
#5
Sarina Jain, Sibasish Patro, Bhushan Darkase, Atul M Dongre, Uday S Khopkar
Smooth muscle hamartoma (SMH) is a benign hamartomatous condition that consists of a dermal proliferation of smooth muscle cells. We hereby report a case of multiple, acquired smooth muscle hamartomas on scalp. A 25-year old male had a 6-year history of multiple, asymptomatic, hyperpigmented plaques on scalp which have been progressively increasing in number and size. Histopathological examination revealed large thick walled blood vessels, in addition to the haphazardly arranged discrete smooth muscle bundles in the reticular dermis...
May 17, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29772224/pharmacokinetics-and-skin-tolerability-of-intracutaneous-zolmitriptan-delivery-in-swine-using-adhesive-dermally-applied-microarray-adam
#6
Joe Nguyen, Hayley Lewis, Ashley Queja, Anh Ngoc Diep, Guillaume Hochart, Mahmoud Ameri
Adhesive Dermally-Applied Microarray (ADAM) is a new drug delivery system that uses microprojections (340 μm long) for intracutaneous drug self-administration. We formulated zolmitriptan, a well-accepted and commonly used migraine medication, for administration using ADAM. In vivo studies were conducted in female prepubescent Yorkshire pigs using ADAM 1.9 mg zolmitriptan, applied to the inner thigh and left in place for 1 hour. Pharmacokinetic studies showed that the ADAM 1.9 mg zolmitriptan delivered with high efficiency (85%) and high absolute bioavailability (77%)...
May 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29771690/heavily-pigmented-epithelioid-melanoma-with-loss-of-protein-kinase-a-regulatory-subunit-%C3%AE-expression
#7
Jarish N Cohen, Jessica A Spies, Fawn Ross, Angela Bohlke, Timothy H McCalmont
Heavily pigmented melanocytic neoplasms are genotypically and phenotypically diverse. Recently, a subset of this histopathologic spectrum was shown to harbor recurrent genetic alterations in the gene-encoding protein kinase A regulatory subunit-α (PRKAR1A). To date, no histopathologic descriptions of melanomas arising from this pathway have been described. We present a case of a darkly pigmented papule arising on the posterior neck of a 28-year-old man. Microscopically, the heavily pigmented compound melanocytic proliferation was centered in the dermis with permeation into the superficial subcutis...
May 16, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29771334/%C3%AE-catenin-activation-in-hair-follicle-dermal-stem-cells-induces-ectopic-hair-outgrowth-and-skin-fibrosis
#8
Yixin Tao, Qingchun Yang, Lei Wang, Jie Zhang, Xuming Zhu, Qianqian Sun, Yunbin Han, Qian Luo, Yushu Wang, Xizhi Guo, Ji Wu, Baojie Li, Xiao Yang, Lin He, Gang Ma
Hair follicle dermal sheath (DS) harbors hair follicle dermal stem cells (hfDSCs), which can be recruited to replenish DS and dermal papilla (DP). Cultured DS cells can differentiate into various cell lineages in vitro. However, it is unclear how its plasticity is modulated in vivo. Wnt/β-catenin signaling plays an important role in maintaining stem cells of various lineages and is required for HF development and regeneration. Here we report that activation of β-catenin in DS generates ectopic HF outgrowth (EF) by reprogramming HF epidermal cells and DS cells themselves, and endows DS cells with hair inducing ability...
May 16, 2018: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/29770208/case-report-polyarteritis-nodosa-or-complicated-henoch-schonlein-purpura-a-rare-case
#9
Sajad Hasanzadeh, Seyedeh Maryam Alavi, Elahe Masnavi, Maryam Rohani, Saeid Jokar
Background: Polyarteritis nodosa (PAN) is a vasculitis that affects medium sized arteries. PAN is a rare disease and requires a high vilgilance for diagnosis. For instance, PAN and Henoch-Schonlein purpura (HSP) have narrowing differential diagnosis. Here, we report a case of PAN. Case presentation : Our patient was a 65 year old woman that came to hospital due to abdominal pain and skin lesion on the right upper and right lower extremities. All rheumatologic tests were negative. A biopsy of the skin lesion was reported as mild hyperkeratosis, slight spongiosis with intact basal layer...
2018: F1000Research
https://www.readbyqxmd.com/read/29769337/entry-of-herpes-simplex-virus-1-into-epidermis-and-dermal-fibroblasts-is-independent-of-the-scavenger-receptor-marco
#10
Katharina Thier, Maureen Möckel, Katja Palitzsch, Katinka Döhner, Beate Sodeik, Dagmar Knebel-Mörsdorf
To enter host cells, herpes simplex virus 1 (HSV-1) initially attaches to cell surface glycosaminoglycans followed by requisite binding to one of several cellular receptors leading to viral internalization. Although virus-receptor interactions have been studied in various cell lines, the contributions of individual receptors to uptake into target tissues such as mucosa, skin or cornea are not well understood. We demonstrated that nectin-1 acts as major receptor for HSV-1 entry into murine epidermis, while HVEM can serve as alternative receptor...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29764244/kinetics-and-tissue-repair-process-following-fractional-bipolar-radiofrequency-treatment
#11
G Kokolakis, L von Eichel, M Ulrich, J Lademann, T Zuberbier, M A Hofmann
INTRODUCTION: Fractionated radiofrequency (RF) tissue tightening is an alternative method to fractionated laser treatment of skin wrinkling, laxity and acne scars, with reduced risk of scarring or persistent pigmentation. The aim of this study was to evaluate and quantify the wound healing process after RF treatment. MATERIALS AND METHODS: 12 patients were treated with a 64-pin fractional bipolar RF device with 60 mJ/pin applied energy. Confocal laser scanning microscopy (CLSM) examination was performed on day 1, day 2, day 7 and day 14 after treatment...
May 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29763986/early-iv-injected-human-dermis-derived-mesenchymal-stem-cells-after-transient-global-cerebral-ischemia-do-not-pass-through-damaged-blood-brain-barrier
#12
Ji Hyeon Ahn, Bai Hui Chen, Joon Ha Park, Bich Na Shin, Tae-Kyeong Lee, Jeong Hwi Cho, Jae Chul Lee, Jeong-Ran Park, Se-Ran Yang, Sungwoo Ryoo, Myoung Cheol Shin, Jun Hwi Cho, Il Jun Kang, Choong Hyun Lee, In Koo Hwang, Young-Myeong Kim, Moo-Ho Won
There is lack of researches on effects of intravenously injected mesenchymal stem cells (MSCs) against transient cerebral ischemia (TCI). We investigated the disruption of the neurovascular unit (NVU), which comprises the blood-brain barrier (BBB) and examined entry of human dermis-derived MSCs (hDMSCs) into the damaged hippocampal CA1 area in a gerbil model of TCI, and their subsequent effects on neuroprotection and cognitive function. Impairments of neurons, and BBB were examined by immunohistochemistry, electron microscopy, and Evans blue and immunoglobulin G (IgG) leakage...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29763974/engineering-a-human-skin-equivalent-to-study-dermis-remodeling-and-epidermis-senescence-in-vitro-after-uva-exposure
#13
Costantino Casale, Giorgia Imparato, Francesco Urciuolo, Francesca Rescigno, Sara Scamardella, Maria Escolino, Paolo A Netti
UVA exposure strongly affects the ageing of human skin by modifying both epidermis and dermis and their cross talk as well. The possibility to get a deep understanding in vitro of such crucial mechanism would have a huge impact in the development of anti-ageing compounds. Here we present a full thickness model of human skin equivalent formed by a millimeter-sized dermis completely composed of fibroblasts embedded in their own extra-cellular matrix (ECM). We show that such endogenous nature of the dermis compartment allows the replication of the complexity of the mutual interactions occurring between cellular and extracellular components of the skin under UVA exposure: (i) oxidative stress formation in the whole tissue (dermis and epidermis); (ii) senescence of germinative layer of epidermal tissue in terms of p63, ki67 and activated caspase-3 regulation; (iii) modification of the collagenous network architecture in the dermis compartment...
May 15, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29762773/animal-and-management-based-welfare-indicators-for-a-conventional-broiler-strain-in-2-barn-types-louisiana-barn-and-closed-barn
#14
Helen Louton, Shana Bergmann, Sven Reese, Michael Erhard, Josef Bachmeier, Beatrice Rösler, Elke Rauch
The aim of this observational study was to describe health- and management-related welfare indicators for a conventional broiler strain housed in 2 barn types (Louisiana barn and closed barn) on the same farm and to assess the impact of age and housing conditions on these indicators. Broilers were examined 4 times in each of 7 fattening periods. Their weight gain, gait score, and further animal-based indicators did not differ between the barn types. On average 46% showed no sign, 51% a minor but visible, and 3% a profound lameness at the end of the fattening period (fattening day 39)...
May 11, 2018: Poultry Science
https://www.readbyqxmd.com/read/29760986/analysis-of-dermal-composite-conditions-using-collagen-absorption-characteristics-in-the-thz-range
#15
Maya Mizuno, Noriko Yaekashiwa, Soichi Watanabe
The absorption characteristics of the dermis were reviewed in the terahertz range from 0.2 to 2 THz. The absorption magnitude of the dermis was higher than that of the epidermis model owing to the inclusion of collagen fibers. The heat denaturation of the collagen and the decrease of water content in the dermis caused a decrease in the absorption magnitude of the dermis. We verified that the absorption magnitude of collagen sheets at 1 THz similarly decreased by nearly 43% upon the heat treatment at approximately 70° C...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760984/the-value-of-ultrahigh-resolution-oct-in-dermatology-delineating-the-dermo-epidermal-junction-capillaries-in-the-dermal-papillae-and-vellus-hairs
#16
Niels Møller Israelsen, Michael Maria, Mette Mogensen, Sophie Bojesen, Mikkel Jensen, Merete Haedersdal, Adrian Podoleanu, Ole Bang
Optical coherence tomography (OCT) imaging of the skin is gaining recognition and is increasingly applied to dermatological research. A key dermatological parameter inferred from an OCT image is the epidermal (Ep) thickness as a thickened Ep can be an indicator of a skin disease. Agreement in the literature on the signal characters of Ep and the subjacent skin layer, the dermis (D), is evident. Ambiguities of the OCT signal interpretation in the literature is however seen for the transition region between the Ep and D, which from histology is known as the dermo-epidermal junction (DEJ); a distinct junction comprised of the lower surface of a single cell layer in epidermis (the stratum basale) connected to an even thinner membrane (the basement membrane)...
May 1, 2018: Biomedical Optics Express
https://www.readbyqxmd.com/read/29760873/early-morphea-simulating-patch-stage-mycosis-fungoides-in-two-cases
#17
Hamid R Ghasemi Basir, Pedram Alirezaei, Aliasghar Rezanejad, Sajjad Daneshyar
Morphea is a skin disorder characterized by thickening of dermis and subcutaneous tissues and loss of adnexal structures. In the early inflammatory stage of morphea, diagnostic histological findings are absent and this may lead to confusion with other inflammatory dermatoses such as mycosis fungoides (MF). We report two cases of early stage morphea mimicking patchstage of MF. Histopathologic examination of biopsies obtained early in the disease course revealed lymphocytic epidermotropism arranged in small pautrier-like collections as well as linear arrangements in dermal- epidermal junction...
April 23, 2018: Dermatology Reports
https://www.readbyqxmd.com/read/29757210/dermatitis-herpetiformis-a-common-extraintestinal-manifestation-of-coeliac-disease
#18
REVIEW
Timo Reunala, Teea T Salmi, Kaisa Hervonen, Katri Kaukinen, Pekka Collin
Dermatitis herpetiformis (DH) is a common extraintestinal manifestation of coeliac disease presenting with itchy papules and vesicles on the elbows, knees, and buttocks. Overt gastrointestinal symptoms are rare. Diagnosis of DH is easily confirmed by immunofluorescence biopsy showing pathognomonic granular immunoglobulin A (IgA) deposits in the papillary dermis. A valid hypothesis for the immunopathogenesis of DH is that it starts from latent or manifest coeliac disease in the gut and evolves into an immune complex deposition of high avidity IgA epidermal transglutaminase (TG3) antibodies, together with the TG3 enzyme, in the papillary dermis...
May 12, 2018: Nutrients
https://www.readbyqxmd.com/read/29756111/glomus-tumor-of-the-stomach
#19
Pelin Yıldız, Zuhal Gücin, Dilek Sema Arıcı, Fatma Ümit Malya, Birol Baysal
Glomus tumor is a rare benign mesenchymal neoplasm derived from the glomus body, an arteriovenous shunt mainly located in dermis and subcutis. The most common localization of this tumor is extremities, especially nailbed. Glomus tumor in the gastrointestinal system is a rare condition. Here we report a gastric glomus tumor to raise awareness of this tumor and show the difficulties in the diagnosis.
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29753790/il-17-promotes-scar-formation-by-inducing-macrophage-infiltration
#20
Julei Zhang, Qiao Qiao, Mengdong Liu, Ting He, Jihong Shi, Xiaozhi Bai, Yijie Zhang, Yan Li, Weixia Cai, Shichao Han, Hao Guan, Dahai Hu
Trauma or burn injuries that affect the deep dermis often produce a hypertrophic scar, which limits patients' joint movement and generates an aesthetic problem. Inflammation is believed to be one of the main pathogenic mechanisms. We found that IL-17 was increased in scar tissues from patients with hypertrophic scar compared with normal skin. Recombinant mouse IL-17 was subcutaneously injected into mice that underwent full-thickness excision surgery to investigate the role of IL-17 in scar formation. Mice stimulated with IL-17 showed aggravated fibrogenesis, delayed wound healing, and increased inflammation...
May 11, 2018: American Journal of Pathology
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