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https://www.readbyqxmd.com/read/29660753/crataegus-special-extract-ws-1442-effects-on-enos-and-microrna-155
#1
Xinwen Wang, Yan Liang, Jian Shi, Hao-Jie Zhu, Barry E Bleske
Increased expression of microRNA 155 (miR-155) results in a decrease in endothelial nitric oxide synthase (eNOS) expression and impaired endothelial function. Factors that have been shown to increase expression of miR-155 may be mitigated by WS 1442, an extract of hawthorn leaves and flowers ( Crataegus special extract) that contains a range of pharmacologically active substances including oligomeric proanthocyanidins and flavonoids. The purpose of this study is to determine the effect of WS 1442 on the expression of miR-155 and eNOS in the presence of tumor necrosis factor (TNF- α )...
April 16, 2018: Planta Medica
https://www.readbyqxmd.com/read/29655677/an-in-vitro-and-in-vivo-study-of-a-4-herb-formula-on-the-management-of-diet-induced-metabolic-syndrome
#2
Elaine Wat, Yanping Wang, Ken Chan, Hon Wai Law, Chi Man Koon, Kit Man Lau, Ping Chung Leung, Choly Yan, Clara Bik San Lau
BACKGROUND: Metabolic syndrome is the cluster of risk factors that leads to increased episodes of cardiovascular disease (CVD). These risk factors include but are not limited to obesity, non-alcoholic fatty liver (NAFLD), dyslipidemia, and type 2 diabetes. Since the pathogenesis of metabolic syndrome has multiple metabolic origins, there is no single treatment for it. Pharmacological approaches consist of separate drugs which target at individual risk factors which pose various side effects...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29588573/vitexin-protects-dopaminergic-neurons-in-mptp-induced-parkinson-s-disease-through-pi3k-akt-signaling-pathway
#3
Ming Hu, Fangming Li, Weidong Wang
Parkinson's disease (PD) is a progressive neurodegenerative disease which is characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Methods: In this study, the neuroprotective effect of vitexin (Vit), a flavonoid compound isolated from Crataegus pinnatifida Bunge was examined in PD models both in vitro and in vivo. Results: On SH-SY5Y cells, methyl-4-phenylpyridine (MPP+ ) treatment suppressed cell viability, induced apoptosis, and increased Bax/Bcl-2 ratio and caspase-3 activity...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29576858/cardioprotective-and-metabolomic-profiling-of-selected-medicinal-plants-against-oxidative-stress
#4
Nadia Afsheen, Khalil-Ur-Rehman, Nazish Jahan, Misbah Ijaz, Asad Manzoor, Khalid Mahmood Khan, Saman Hina
In this research work, the antioxidant and metabolomic profiling of seven selected medicinally important herbs including Rauvolfia serpentina , Terminalia arjuna , Coriandrum sativum , Elettaria cardamom , Piper nigrum , Allium sativum , and Crataegus oxyacantha was performed. The in vivo cardioprotective potential of these medicinal plants was evaluated against surgically induced oxidative stress through left anterior descending coronary artery ligation (LADCA) in dogs. The antioxidant profiling of these plants was done through DPPH and DNA protection assay...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29534982/phenylpropanoids-from-the-fruit-of-crataegus-pinnatifida-exhibit-cytotoxicity-on-hepatic-carcinoma-cells-through-apoptosis-induction
#5
Rui Guo, Bin Lin, Xin-Yue Shang, Le Zhou, Guo-Dong Yao, Xiao-Xiao Huang, Shao-Jiang Song
Eight new phenylpropanoids (1a/1b, 2-4, 5a/5b and 6) including two pairs of enantiomers (1a/1b and 5a/5b), along with a known analogue (7) were isolated from the fruit of Crataegus pinnatifida. Their structures were elucidated using comprehensive spectroscopic methods. Compounds 1a/1b and 5a/5b were separated successfully by chiral chromatographic column. The absolute configurations of enantiomers were determined by comparison between the experimental and calculated electronic circular dichroism (ECD) spectra...
March 10, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29521116/two-new-sesquineolignans-from-the-seeds-of-crataegus-pinnatifida-and-their-%C3%AE-amyloid-aggregation-inhibitory-activitiy
#6
Rui Guo, Le Zhou, Peng Zhao, Xiao-Bo Wang, Xiao-Xiao Huang, Shao-Jiang Song
Two new sesquineolignans, hawthornsesquinins K and L (1 and 2), were isolated from the seeds of Crataegus pinnatifida. Their structures were determined by spectroscopic analyses, including 1D, 2D NMR and HRESIMS data. All isolated compounds were tested for their β-amyloid aggregation inhibitory activity and neuroprotective effects against H2 O2 -induced damage in SH-SY5Y cells. The results indicated that compound 1 showed prominent inhibition of Aβ1-42 aggregation and significant neuroprotective effect on H2 O2 -induced cellular damage in SH-SY5Y cells...
March 9, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29477090/cardioprotective-effect-of-resistance-training-and-crataegus-oxyacantha-extract-on-ischemia-reperfusion-induced-oxidative-stress-in-diabetic-rats
#7
Kamal Ranjbar, Ebrahim Zarrinkalam, Iraj Salehi, Alireza Komaki, Bayan Fayazi
Discovering an effective approach to limit infarction size after ischemia-reperfusion has a clinical importance in diabetics. We investigated the anti-myocardial ischemia-reperfusion injury effect of resistance training and Crataegus oxyacantha extract on diabetic rats. To this end, 50 male Wistar rats were randomly divided into 5 groups: the sedentary control (SC), sedentary diabetic (SD), resistance trained diabetic (RD), diabetic plus C. oxyacantha extract treatment (CD) and resistance trained diabetic plus C...
February 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29457331/a-strain-of-streptomyces-sp-isolated-from-rhizospheric-soil-of-crataegus-oxycantha-producing-nalidixic-acid-a-synthetic-antibiotic
#8
Nidhi Arora, Sunil Kumar, N Satti, Asif Ali, Prasoon Gupta, Meenu Katoch
AIM: Exploration of microbes isolated from rhizospheric soil of Crataegus oxycantha for bioactive natural products. METHODS AND RESULTS: A strain of Streptomyces sp. (C-7) was isolated from rhizospheric soil of Crataegus oxycantha. The 16S rRNA gene sequence of strain C-7 displayed 99% sequence similarity with different Streptomyces species. The highest score was displayed for Streptomyces sp. strain Chy2-8 followed by Streptomyces violarus strain NBRC13104 and Streptomyces arenae strain ISP5293...
February 19, 2018: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29425590/network-pharmacology-based-analysis-of-chinese-herbal-naodesheng-formula-for-application-to-alzheimer-s-disease
#9
Xiao-Cong Pang, De Kang, Jian-Song Fang, Ying Zhao, Lv-Jie Xu, Wen-Wen Lian, Ai-Lin Liu, Guan-Hua DU
Naodesheng (NDS) formula, which consists of Rhizoma Chuanxiong, Lobed Kudzuvine, Carthamus tinctorius, Radix Notoginseng, and Crataegus pinnatifida, is widely applied for the treatment of cardio/cerebrovascular ischemic diseases, ischemic stroke, and sequelae of cerebral hemorrhage, etc. At present, the studies on NDS formula for Alzheimer's disease (AD) only focus on single component of this prescription, and there is no report about the synergistic mechanism of the constituents in NDS formula for the potential treatment of dementia...
January 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29369521/brief-challenges-on-medicinal-plants-an-eye-opening-look-at-ageing-related-disorders
#10
Geir Bjørklund, Maryam Dadar, Natália Martins, Salvatore Chirumbolo, Bey Hing Goh, Kateryna Smetanina, Roman Lysiuk
Several studies have reported that nature-derived antioxidants may prevent free radicals over-production and therefore control the onset and prevent the exacerbation of different kinds of diseases caused by oxidative stress and redox-derived stressors, including ageing, fundamentally by suppressing the oxidative byproducts-mediated degradation. Naturally derived antioxidants exert their anti-ageing action via a panoply of signalling systems, many of which engaging reactive oxygen (ROS) and nitrogen (RNS) species scavenging, with the Nrf2/Keap1-ARE system and improving the many survival genes and functions (such as the pathway mTOR/Foxo/SIRT1) able to slow cellular senescence...
January 25, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29200740/evaluation-of-hypolipidemic-and-antioxidant-effects-in-phenolrich-fraction-of-crataegus-pinnatifida-fruit-in-hyperlipidemia-rats-and-identification-of-chemical-composition-by-ultra-performance-liquid-chromatography-coupled-with-quadropole-time-of-flight-mass
#11
Feng Shao, Lifei Gu, Huijuan Chen, Ronghua Liu, Huilian Huang, Lanying Chen, Ming Yang
Background: Hawthorn ( Crataegus pinnatifida ) fruit has enjoyed a great popularity as a pleasant-tasting food associated with hypolipidemic and antioxidant effects. Objective: Our aim was to screen the effective fraction of hawthorn fruit in the treatment of hyperlipidemia rats. Materials and Methods: In this study, ethanol extract of hawthorn fruit (Fr.1) and four fractionated extracts (Fr.2, Fr.3, Fr.4, and Fr.5) were compared to total phenol content evaluated using Folin-Ciocalteu method, and hypolipidemic and antioxidant effects were assessed in hyperlipidemic rats...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29151068/crataegus-special-extract-ws-1442-up-to-date-review-of-experimental-and-clinical-experiences
#12
M Zorniak, B Szydlo, T F Krzeminski
Extracts and tinctures made from Crataegus spp. (Hawthorn) have been used as cardioprotective remedies since ancient times. WS 1442 special extract, manufactured by Dr. W. Schwabe Pharmaceuticals©, made from Crataegus spp. Leaves and flowers is one of the most studied and popular of preparations received from Hawthorn. It is integral, and most important active component of such herbal drugs as Crataegutt® novo 450, and CardioMax®. This standardized extract contains 18.75% oligomeric procyanidins (OPC), which have beneficial cardioprotective values and play a role as free-radicals scavengers, that protect the ischemic heart tissue from neutrophile elastase action successions...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29135932/extracts-of-crataegus-oxyacantha-and-rosmarinus-officinalis-attenuate-ischemic-myocardial-damage-by-decreasing-oxidative-stress-and-regulating-the-production-of-cardiac-vasoactive-agents
#13
Raúl Enrique Cuevas-Durán, Juan Carlos Medrano-Rodríguez, María Sánchez-Aguilar, Elizabeth Soria-Castro, María Esther Rubio-Ruíz, Leonardo Del Valle-Mondragón, Alicia Sánchez-Mendoza, Juan Carlos Torres-Narvaéz, Gustavo Pastelín-Hernández, Luz Ibarra-Lara
Numerous studies have supported a role for oxidative stress in the development of ischemic damage and endothelial dysfunction. Crataegus oxyacantha ( Co ) and Rosmarinus officinalis ( Ro ) extracts are polyphenolic-rich compounds that have proven to be efficient in the treatment of cardiovascular diseases. We studied the effect of extracts from Co and Ro on the myocardial damage associated with the oxidative status and to the production of different vasoactive agents. Rats were assigned to the following groups: (a) sham; (b) vehicle-treated myocardial infarction (MI) (MI-V); (c) Ro extract-treated myocardial infarction (MI- Ro ); (d) Co extract-treated myocardial infarction (MI- Co ); or (e) Ro+Co -treated myocardial infarction (MI- Ro+Co )...
November 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29133340/effects-of-hawthorn-crataegus-pentagyna-leaf-extract-on-electrophysiologic-properties-of-cardiomyocytes-derived-from-human-cardiac-arrhythmia-specific-induced-pluripotent-stem-cells
#14
Sara Pahlavan, Marziyeh Shalchi Tousi, Mahdi Ayyari, Abolfazl Alirezalu, Hassan Ansari, Tomo Saric, Hossein Baharvand
Cardiac arrhythmias are major life-threatening conditions. The landmark discovery of induced pluripotent stem cells has provided a promising in vitro system for modeling hereditary cardiac arrhythmias as well as drug development and toxicity testing. Nowadays, nutraceuticals are frequently used as supplements for cardiovascular therapy. Here we studied the cardiac effects of hawthorn ( Crataegus pentagyna) leaf extract using cardiomyocytes (CMs) differentiated from healthy human embryonic stem cells, long QT syndrome type 2 (LQTS2), and catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) patient-specific induced pluripotent stem cells...
March 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29115158/lignans-from-the-seeds-of-chinese-hawthorn-crataegus-pinnatifida-var-major-n-e-br-against-%C3%AE-amyloid-aggregation
#15
Xiao-Xiao Huang, Yang Xu, Ming Bai, Le Zhou, Shao-Jiang Song, Xiao-Bo Wang
Phytochemical investigation on the seeds of hawthorn (Crataegus spp.) led to the isolation of a new compound, (7'R, 8'R, 8S)-isolariciresinol (1), along with six known compounds (2-7). The structures of all compounds were determined based on spectroscopic data interpretation. The Aβ1-42 inhibition activity of all isolated compounds was evaluated in vitro. As a result, compounds 5 and 6 showed stronger inhibition of Aβ1-42 aggregation than curcumin, with inhibition rates of 70.59 and 68.14% at 20 μM. The possible mechanism of interaction between Aβ1-42 and the active compounds 5 and 6 was also investigated by molecular docking...
November 8, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29091859/vitexin-inhibits-inflammation-in-murine-ovalbumin-induced-allergic-asthma
#16
Cláudio Luís Venturini, Antonio Macho, Karuppusamy Arunachalam, Danielle Ayr Tavares de Almeida, Suellen Iara Guirra Rosa, Eduarda Pavan, Sikiru Olaitan Balogun, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins
Vitexin is an important component of various medicinal plants frequently used to treat asthma, such as Crataegus spp., Vitex spp., Passiflora spp., and Echinodorus spp. However, there is no information about the vitexin potential as anti-asthmatic. The aim of the present work was to evaluate the anti-hypersensitive activity of vitexin in a murine ovalbumin (OVA)-induced allergic asthma model. Mice were sensitized to OVA by i.p. injection on days 1st and 10th, followed by a daily challenge with OVA using a nebulizer, from days 19th to 24th...
January 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29080984/benefit-risk-assessment-of-crataegus-extract-ws%C3%A2-1442-an-evidence-based-review
#17
REVIEW
Christian J F Holubarsch, Wilson S Colucci, Jaan Eha
Preparations from Crataegus (hawthorn) have a long history in the treatment of heart failure. WS 1442 is a dry extract from hawthorn leaves with flowers (4-6.6:1), extraction solvent of ethanol 45% (w/w), adjusted to 17.3-20.1% of oligomeric procyanidins. Nonclinical studies show that WS 1442 has positive inotropic and antiarrhythmic properties and protects the myocardium from ischemic damage, reperfusion injury, and hypertension-related hypertrophy, improves endothelial functions such as NO synthesis, and delays endothelial senescence...
October 28, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29039328/synergistic-interactions-of-polyphenols-and-their-effect-on-antiradical-potential
#18
Saba Aslam, Nazish Jahan, KhalilUr Rahman, Fatiqa Zafar, M Yasin Ashraf
The aim of the current study was to evaluate interactions among polyphenols from different plants and their effect on antioxidant potential. Different mixtures of plant extracts of Crataegus oxyacantha (C), Elettaria cardamomum (Cr), Terminalia arjuna (T) and Rauvolfia serpentina (R) were prepared and evaluated for total phenolics, flavonoid contents, and antioxidant activity. A correlation was also established between total phenolics, flavonoids and antioxidant activity. Comparative evaluation revealed that phenolics, flavonoids and antioxidant activity were found high in plant extracts mixtures than individual plants...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29029209/genetic-evidence-for-the-introduction-of-rhagoletis-pomonella-diptera-tephritidae-into-the-northwestern-united-states
#19
Sheina B Sim, Meredith M Doellman, Glen R Hood, Wee L Yee, Thomas H Q Powell, Dietmar Schwarz, Robert B Goughnour, Scott P Egan, Gilbert St Jean, James J Smith, Tracy E Arcella, Jason D K Dzurisin, Jeffrey L Feder
The apple maggot fly, Rhagoletis pomonella Walsh (Diptera: Tephritidae), is a serious quarantine pest in the apple-growing regions of central Washington and Oregon. The fly is believed to have been introduced into the Pacific Northwest via the transport of larval-infested apples near Portland, Oregon, within the last 40 yr. However, R. pomonella also attacks native black hawthorn, Crataegus douglasii Lindley (Rosales: Rosaceae), and introduced ornamental hawthorn, Crataegus monogyna Jacquin, in the region. It is, therefore, possible that R...
December 5, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29028975/comparative-responses-of-rhagoletis-zephyria-and-rhagoletis-pomonella-diptera-tephritidae-to-commercial-and-experimental-sticky-traps-and-odors-in-washington-state
#20
COMPARATIVE STUDY
Wee L Yee, Robert B Goughnour, Jeffrey L Feder, Charles E Linn, Dong H Cha
Rhagoletis zephyria Snow and Rhagoletis pomonella (Walsh) (Diptera: Tephritidae) are morphologically similar flies that attack white-colored snowberry fruit (Symphoricarpos spp.) and yellow/red or dark-colored apple/hawthorn fruit (Malus/Crataegus spp.), respectively. The two flies are caught together on traps in R. pomonella surveys in the western United States, increasing labor needed to process catches. Comparing responses of the two species with different traps could help identify best practices for reducing R...
December 8, 2017: Environmental Entomology
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