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https://www.readbyqxmd.com/read/28277037/fruit-extract-of-the-medicinal-plant-crataegus-oxyacantha-exerts-genotoxic-and-mutagenic-effects-in-cultured-cells
#1
Ana Paula Oliveira de Quadros, Dania Elisa Christofoletti Mazzeo, Maria Aparecida Marin-Morales, Fábio Ferreira Perazzo, Paulo Cesar Pires Rosa, Edson Luis Maistro
Crataegus oxyacantha, a plant of the Rosaceae family also known "English hawthorn, haw, maybush, or whitethorn," has long been used for medicinal purposes such as digestive disorders, hyperlipidemia, dyspnea, inducing diuresis, and preventing kidney stones. However, the predominant use of this plant has been to treat cardiovascular disorders. Due to a lack of studies on the genotoxicity of C. oxyacantha, this investigation was undertaken to determine whether its fruit extract exerts cytotoxic, genotoxic, or clastogenic/aneugenic effects in leukocytes and HepG2 (liver hepatocellular carcinoma) cultured human cells, or mutagenic effects in TA100 and TA98 strains of Salmonella typhimurium bacterium...
February 17, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28165392/sphingosine-kinase-1-involves-the-inhibitory-action-of-hif-1%C3%AE-by-chlorogenic-acid-in-hypoxic-du145-cells
#2
Myoung-Sun Lee, Seon-Ok Lee, Kyu-Ri Kim, Hyo-Jeong Lee
Hypoxia enhances cancer development in a solid tumor. Hypoxia-inducible factor-1 α (HIF-1α) is a transcription factor that is dominantly expressed under hypoxia in solid tumor cells and is a key factor that regulates tumor. HIF-1α regulates several target genes involved in many aspects of cancer progression, including angiogenesis, metastasis, anti-apoptosis and cell proliferation as well as imparts resistance to cancer treatment. In this study, we assessed Crataegus Pinnatifida Bunge var. typical Schneider ethanol extract (CPE) for its anti-cancer effects in hypoxia-induced DU145 human prostate cancer cell line...
February 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28123324/antiaging-effects-of-the-mixture-of-panax-ginseng-and-crataegus-pinnatifida-in-human-dermal-fibroblasts-and-healthy-human-skin
#3
Eunson Hwang, Sang-Yong Park, Chang Shik Yin, Hee-Taek Kim, Yong Min Kim, Tae Hoo Yi
BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P...
January 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28119096/hawthorn-crataegus-pinnatifida-bunge-leave-flavonoids-attenuate-atherosclerosis-development-in-apoe-knock-out-mice
#4
Pengzhi Dong, Lanlan Pan, Xiting Zhang, Wenwen Zhang, Xue Wang, Meixiu Jiang, Yuanli Chen, Yajun Duan, Honghua Wu, Yantong Xu, Peng Zhang, Yan Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: Hawthorn (Crataegus pinnatifida Bunge) leave have been used to treat cardiovascular diseases in China and Europe. Hawthorn leave flavonoids (HLF) are the main part of extraction. Whether hawthorn leave flavonoids could attenuate the development of atherosclerosis and the possible mechanism remain unknown. MATERIALS AND METHODS: High-fat diet (HFD) mixed with HLF at concentrations of 5mg/kg and 20mg/kg were administered to apolipoprotein E (apoE) knock out mice...
January 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28078623/identification-of-host-fruit-volatiles-from-snowberry-symphoricarpos-albus-attractive-to-rhagoletis-zephyria-flies-from-the-western-united-states
#5
Dong H Cha, Shannon B Olsson, Wee L Yee, Robert B Goughnour, Glen R Hood, Monte Mattsson, Dietmar Schwarz, Jeffrey L Feder, Charles E Linn
A mixture of behaviorally active volatiles was identified from the fruit of snowberry, Symphoricarpos albus laevigatus, for Rhagoletis zephyria flies reared from snowberry fruit. A nine-component blend containing 3-methylbutan-1-ol (3%), dimethyl trisulfide (1%), 1-octen-3-ol (40%), myrcene (8%), nonanal (9%), linalool (13%), (3E)-4,8-dimethyl-1,3,7-nonatriene (DMNT, 6%), decanal (15%), and β-caryophyllene (5%) was identified that gave consistent electroantennogram activity and was behaviorally active in flight tunnel tests...
January 11, 2017: Journal of Chemical Ecology
https://www.readbyqxmd.com/read/28055105/restoration-of-perivascular-adipose-tissue-function-in-diet-induced-obese-mice-without-changing-bodyweight
#6
Ning Xia, Sabrina Weisenburger, Egon Koch, Martin Burkart, Gisela Reifenberg, Ulrich Förstermann, Huige Li
BACKGROUND AND PURPOSE: We have recently shown that a reduced function of endothelial nitric oxide synthase (eNOS) in the perivascular adipose tissue (PVAT) contributes crucially to obesity-induced vascular dysfunction in mice. The current study was conducted to test the hypothesis that vascular dysfunction in obesity can be reversed by in vivo improvement of PVAT eNOS activity. EXPERIMENTAL APPROACH: Male C57BL/6J mice were fed a high-fat diet (HFD) for 22 weeks to induce obesity...
January 5, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28025124/major-triterpenoids-in-chinese-hawthorn-crataegus-pinnatifida-and-their-effects-on-cell-proliferation-and-apoptosis-induction-in-mda-mb-231-cancer-cells
#7
Lingrong Wen, Ruixue Guo, Lijun You, Arshad Mehmood Abbasi, Tong Li, Xiong Fu, Rui Hai Liu
The cytotoxicity and antiproliferative effect of phytochemicals presenting in the fruits of Chinese hawthorn (Crataegus pinnatifida) were evaluated. Shanlihong (Crataegus pinnatifida Bge. var. major N.E.Br.) variety possessed significant levels of flavonoids and triterpenoids, and showed potent antiproliferative effect against HepG2, MCF-7 and MDA-MB- 231 human cancer cells lines. Triterpenoids-enriched fraction (S9) prepared by Semi-preparative HPLC, and its predominant ingredient ursolic acid (UA) demonstrated remarkably antiproliferative activities for all the tested cancer cell lines...
February 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28006832/the-dual-edema-preventing-molecular-mechanism-of-the-crataegus-extract-ws-1442-can-be-assigned-to-distinct-phytochemical-fractions
#8
Simone Fuchs, Iris Bischoff, Elisabeth A Willer, Jacqueline Bräutigam, Martin F Bubik, Clemens A J Erdelmeier, Egon Koch, Maria T Faleschini, Maria De Mieri, Milena Bauhart, Stefan Zahler, Andreas Hensel, Matthias Hamburger, Olivier Potterat, Robert Fürst
The hawthorn (Crataegus spp.) extract WS 1442 is used against mild forms of chronic heart failure. This disease is associated with endothelial barrier dysfunction and edema formation. We have recently shown that WS 1442 protects against this dysfunction by a dual mechanism: it both promotes endothelial barrier integrity by activation of a barrier-enhancing pathway (cortactin activation) and inhibits endothelial hyperpermeability by blocking a barrier disruptive pathway (calcium signaling). In this study, we aimed to identify the bioactive compounds responsible for these actions by using a bioactivity-guided fractionation approach...
December 22, 2016: Planta Medica
https://www.readbyqxmd.com/read/28003447/sensory-specificity-and-speciation-a-potential-neuronal-pathway-for-host-fruit-odour-discrimination-in-rhagoletis-pomonella
#9
Cheyenne Tait, Srishti Batra, Sree Subha Ramaswamy, Jeffrey L Feder, Shannon B Olsson
Behavioural changes in habitat or mate choice can trigger population divergence, leading to speciation. However, little is known about the neurological bases for such changes. Rhagoletis pomonella (Diptera: Tephritidae) is a model for ecological speciation via host plant shifts. Within the past 180 years, Rhagoletis flies infesting hawthorn (Crataegus spp.) shifted to attack domesticated apple (Malus pumila). The two populations differ in their olfactory preferences for apple versus hawthorn fruit. Here, we looked for patterns of sensory organization that may have contributed to this shift by characterizing the morphology, specificity and distribution of olfactory sensory neurons (OSNs) on the antennae of Rhagoletis responding to host fruit and non-host volatiles...
December 28, 2016: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/27976162/crataegus-special-extract-ws%C3%A2-1442-modulates-aortic-expression-of-micrornas-in-mice-possible-contribution-to-prophylaxis-and-therapy-of-cardiac-disorders
#10
S Kraft, K Schötz, U Scheyhing, N Xia, E Schramm, H Li, E Koch
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27976091/a-new-pharmacology-for-crataegus-ssp-the-standardized-extract-ws%C3%A2-1442-promotes-cardiogenesis-from-stem-cells-in-vitro
#11
J Halver, C Carrillo García, D Schade
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975709/antioxidant-capacity-of-crataegus-monogyna-and-crataegus-pentagyna-leaves-and-fruits-harvested-from-the-danube-delta
#12
O C Bujor, C P Stefanache, I Volf, D Danila
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27975676/effects-of-crataegus-pentagyna-on-cardiomyocytes-cms-differentiated-from-cpvt1-patient-derived-induced-pluripotent-stem-cells-ipscs
#13
S Pahlavan, M Ayyari, A Alirezalu, M S Tousi, H Ansari, H Baharvand
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27925492/antibacterial-antioxidant-and-anti-proliferative-properties-and-zinc-content-of-five-south-portugal-herbs
#14
COMPARATIVE STUDY
Ricardo Nunes, Pawel Pasko, Malgorzata Tyszka-Czochara, Agnieszka Szewczyk, Marek Szlosarczyk, Isabel S Carvalho
CONTEXT: Crataegus monogyna L. (Rosaceae) (CM), Equisetum telmateia L. (Equisataceae) (ET), Geranium purpureum Vil. (Geraniaceae) (GP), Mentha suaveolens Ehrh. (Lamiaceae) (MS), and Lavandula stoechas L. spp. luisieri (Lamiaceae) (LS) are all medicinal. OBJECTIVE: To evaluate the antioxidant, antiproliferative and antimicrobial activities of plant extracts and quantify individual phenolics and zinc. MATERIAL AND METHODS: Aerial part extracts were prepared with water (W), ethanol (E) and an 80% mixture (80EW)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27807684/inhibition-of-murine-norovirus-and-feline-calicivirus-by-edible-herbal-extracts
#15
Dong Joo Seo, Changsun Choi
Human noroviruses (HuNoVs) cause foodborne and waterborne viral gastroenteritis worldwide. Because HuNoV culture systems have not been developed thus far, no available medicines or vaccines preventing infection with HuNoVs exist. Some herbal extracts were considered as phytomedicines because of their bioactive components. In this study, the inhibitory effects of 29 edible herbal extracts against the norovirus surrogates murine norovirus (MNV) and feline calicivirus (FCV) were examined. FCV was significantly inhibited to 86...
November 2, 2016: Food and Environmental Virology
https://www.readbyqxmd.com/read/27792149/herbal-formula-ht048-attenuates-diet-induced-obesity-by-improving-hepatic-lipid-metabolism-and-insulin-resistance-in-obese-rats
#16
Yoon Hee Lee, Bora Jin, Sung Hyun Lee, MiKyung Song, HyeonHui Bae, Byung Jae Min, Juyeon Park, Donghun Lee, Hocheol Kim
It is well established that obesity causes a variety of chronic diseases such as cardiovascular diseases and diabetes. Despite the diligent scientific efforts to find effective ways to lower the level of obesity, the size of obese population grows continuously around the world. Here we present the results that show feeding diet containing HT048, a mixture of the extracts of Crataegus pinnatifida leaves and Citrus unshiu peel, two of the well-known traditional herbal medicines in Eastern Asia, decreases obesity in rats...
October 25, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27776376/single-laboratory-validation-for-the-determination-of-flavonoids-in-hawthorn-leaves-and-finished-products-by-lc-uv
#17
Elizabeth M Mudge, Ying Liu, Jensen A Lund, Paula N Brown
Suitably validated analytical methods that can be used to quantify medicinally active phytochemicals in natural health products are required by regulators, manufacturers, and consumers. Hawthorn (Crataegus) is a botanical ingredient in natural health products used for the treatment of cardiovascular disorders. A method for the quantitation of vitexin-2″-O- rhamnoside, vitexin, isovitexin, rutin, and hyperoside in hawthorn leaf and flower raw materials and finished products was optimized and validated according to AOAC International guidelines...
November 2016: Planta Medica
https://www.readbyqxmd.com/read/27755960/cell-dedifferentiation-callus-induction-and-somatic-embryogenesis-in-crataegus-spp
#18
N Taimori, D Kahrizi, V Abdossi, A H Papzan
The present study describes the effects of light conditions, different kinds and concentrations of auxins [Naphthylacetic acid (NAA) and dichlorophenoxyacetic acid (2,4-D)] with cytokinin (Kin) in MS medium on callus induction and embryogenesis in Crataegus pseudoheterophylla, C. aronia and C.meyeri. At first leave explants sections were cultured on different combinations of plant growth regulators in dark and light for callus initiation and light conditions to evaluation the percentage and duration of survival, callus diameter, callus fresh weight and dry...
September 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27754461/in-vitro-study-on-anti-hepatitis-c-virus-activity-of-spatholobus-suberectus-dunn
#19
Shao-Ru Chen, An-Qi Wang, Li-Gen Lin, Hong-Cong Qiu, Yi-Tao Wang, Ying Wang
Hepatitis C virus (HCV) infects 200 million people worldwide, and 75% of HCV cases progress into chronic infections, which consequently cause cirrhosis and hepatocellular carcinoma. HCV infection is treated with currently considered standard drugs, including direct anti-viral agents (DAAs), alone or in combination with peginterferon-α plus ribavirin. However, sustained viral responses vary in different cohorts, and high costs limit the broad use of DAAs. In this study, the ethanol and water extracts of 12 herbs from Lingnan in China were examined in terms of their inhibitory effect on HCV replication...
October 15, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27748195/adonis-sp-convallaria-sp-strophanthus-sp-thevetia-sp-and-leonurus-sp-cardiotonic-plants-with-known-traditional-use-and-a-few-preclinical-and-clinical-studies
#20
Ilkay Erdogan Orhan, Alper Gokbulut, F Sezer Senol
Plants have been always a fruitful source of active metabolites against many human disorders, where cardiovascular (CV) diseases have been one of the major health problems all over the world. There are some clinically proved medicinal plants with cardioprotective effects such as Crataegus monogyna and C. oxyacantha (hawthorn) from Rosaceae. On the other hand, cardiac glycosides, present in a number of plant species, are well-known for their cardiotonic activity. However, we encountered such a fact that very less number of studies are available on the source plants; e...
October 10, 2016: Current Pharmaceutical Design
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