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https://www.readbyqxmd.com/read/27771932/guggulsterone-and-its-role-in-chronic-diseases
#1
Takanori Yamada, Ken Sugimoto
Guggulsterone is a plant sterol derived from gum resin of Commiphora wightii. The gum resin from guggul plants has been used for thousand years in Ayurveda to treat various disorders, including internal tumors, obesity, liver disorders, malignant sores and ulcers, urinary complaints, intestinal worms, leucoderma, sinuses, edema, and sudden paralytic seizures. Guggulsterone has been identified a bioactive components of this gum resin. This plant steroid has been reported to work as an antagonist of certain nuclear receptors, especially farnesoid X receptor, which regulates bile acids and cholesterol metabolism...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27716154/effect-of-the-herbal-mixture-composed-of-aloe-vera-henna-adiantum-capillus-veneris-and-myrrha-on-wound-healing-in-streptozotocin-induced-diabetic-rats
#2
Hamid Galehdari, Samira Negahdari, Mahnaz Kesmati, Anahita Rezaie, Gholamreza Shariati
BACKGROUND: Wound healing is often impaired in diabetic animals and humans. Matrix metalloproteases act as pro-inflammatory agents in physiological wound healing pathways by stimulating cytokines including the interleukins, IL6, IL1A and IL1B, and the tumor necrosis factor and transforming growth factor beta1. Botanicals are traditionally used to assist healing of different types of wounds, because they produce fewer side effects. Our specific aim here was to develop a plant-based recipe supporting effective wound healing in diabetic animals...
October 6, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27677871/z-guggulsterone-improves-the-scopolamine-induced-memory-impairments-through-enhancement-of-the-bdnf-signal-in-c57bl-6j-mice
#3
Zhuo Chen, Chao Huang, Wenbin Ding
Memory impairment is a common symptom in patients with neurodegenerative disorders, and its suppression could be beneficial to improve the quality of life of those patients. Z-guggulsterone, a compound extracted from the resin of plant Commiphora whighitii, exhibits numerous pharmacological effects in clinical practice, such as treatment of inflammation, arthritis, obesity and lipid metabolism disorders. However, the role and possible mechanism of Z-guggulsterone on brain-associated memory impairments are largely unknown...
December 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27392030/trypanocidal-activity-of-ethanolic-extracts-of-commiphora-swynnertonii-burtt-on-trypanosoma-congolense
#4
Yakob P Nagagi, Richard S Silayo, Eliningaya J Kweka
BACKGROUND: African trypanosomosis is the disease caused by extracellular protozoan parasites of the genus Trypanosoma transmitted by tsetse flies. The current study has evaluated the trypanocidal activity of Commiphora swynnertonii extracts on Trypanosoma congolense. METHODS: The effect of ethanolic stem bark and resinous extracts on motility of T. congolense was evaluated by in vitro study at concentrations of 2 mg/ml and 4 mg/ml. Then, trypanocidal activity was evaluated by drug incubation infectivity test using mice at concentrations of 0...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27386000/evaluation-of-the-antibacterial-efficacy-of-azadirachta-indica-commiphora-myrrha-glycyrrhiza-glabra-against-enterococcus-faecalis-using-real-time-pcr
#5
Suresh Anand, Mathan Rajan, Nagendrababu Venkateshbabu, Deivanayagam Kandaswamy, Yarramreddy Shravya, Kalaiselvam Rajeswari
AIM: To compare the antibacterial efficacy of Azadirachta indica (Neem), Commiphora myrrha (Myrrh), Glycyrrhiza glabra (Liquorice) with 2% Chlorhexidine (CHX) against E. faecalis by using Real Time PCR. MATERIALS AND METHODS: A total of fifty teeth specimens (n=50) were inoculated with E. faecalis for 21 days. Specimens were divided into five groups (Group 1: Myrrh, Group 2: Neem, Group 3: Liquorice, Group 4: 2% CHX and Group 5: Saline (negative control)). The intracanal medicaments were packed inside the tooth...
2016: Open Dentistry Journal
https://www.readbyqxmd.com/read/27330531/sensitivity-of-clinical-isolates-of-candida-to-essential-oils-from-burseraceae-family
#6
Miloš Nikolic, Marija Smiljkovic, Tatjana Markovic, Ana Cirica, Jasmina Glamoclija, Dejan Markovic, Marina Sokovic
The aim of this study was to investigate the chemical composition and antifungal activity of four commercial essential oils from the Burseraceae family - two Boswellia carterii Flueck oils, Canarium luzonicum (Blume) A. Gray oil, and Commiphora myrrha (Nees) Engl oil, against most common Candida spp. recovered from the human oral cavity. The essential oil samples were analyzed by GC-FID and GC/MS. The analysis showed that major essential oils' components were α-pinene (23.04 % and 31.84 %), limonene (45.62 %) and curzerene (34...
2016: EXCLI journal
https://www.readbyqxmd.com/read/27257198/complete-genome-sequence-of-the-endophytic-fungus-diaporthe-phomopsis-ampelina
#7
J Savitha, S D Bhargavi, V K Praveen
Diaporthe ampelina was isolated as an endophytic fungus from the root of Commiphora wightii, a medicinal plant collected from Dhanvantri Vana, Bangalore University, Bangalore, India. The whole genome is 59 Mb, contains a total of 905 scaffolds, and has a G+C content of 51.74%. The genome sequence of D. ampelina shows a complete absence of lovastatin (an anticholesterol drug) gene cluster.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27132716/chinese-vegetative-materia-medica-in-a-venereological-treatise-by-jean-astruc-from-1740
#8
Jacek Drobnik
ETHNOPHARMACOLOGICAL RELEVANCE: Historical medical sources can be still queried for forgotten cures and remedies. Traditional Chinese medicine has dealt with lues venerea (syphilis) since the Five Dynasties period (10th century). Chinese indigenous materia medica and remedies recorded, studied or imported by the Europeans can reveal known or quite unknown medicinal plants. The studied Jean Astruc's work is a published ethnopharmacological survey carried out in Beijing in the 1730s and it deserves a modern interpretation...
July 1, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27104031/nematicidal-and-antimicrobial-activities-of-methanol-extracts-of-17-plants-of-importance-in-ethnopharmacology-obtained-from-the-arabian-peninsula
#9
Adel Al-Marby, Chukwunonso Ecc Ejike, Muhammad Jawad Nasim, Nasser A Awadh-Ali, Rwaida A Al-Badani, Ghanem Ma Alghamdi, Claus Jacob
AIM/BACKGROUND: The development of resistance to synthetic drugs by target organisms is a major challenge facing medicine, yet locked within plants are phytochemicals used in herbal medicine (especially in the Arabian Peninsula) that may find application in this regard. In pursuit of unlocking these "hidden treasures," the methanol extracts of leaves, aerial parts, fruits, and resins of 17 plants used in the Arabian Peninsula were screened for antimicrobial activities. MATERIALS AND METHODS: The nematicidal, antibacterial, and antifungal activities were determined using appropriate assays...
March 2016: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/27069687/scar-marker-for-identification-and-discrimination-of-commiphora-wightii-and-c-myrrha
#10
Pramod Kumar Sairkar, Anjana Sharma, N P Shukla
Commercially important Commiphora species are drought-tolerant plants and they are leafless for most of the year. Therefore, it is necessary to develop some molecular marker for the identification. Intended for that, in the present study, species-specific, sequence-characterized amplified regions (SCAR) markers were developed for proficient and precise identification of closely related species Commiphora wightii and C. myrrha, which may ensure the quality, safety, and efficacy of medicines made from these plants through adulterous mixing of these plants...
2016: Molecular Biology International
https://www.readbyqxmd.com/read/27006594/beetle-and-plant-arrow-poisons-of-the-ju-hoan-and-hai-om-san-peoples-of-namibia-insecta-coleoptera-chrysomelidae-plantae-anacardiaceae-apocynaceae-burseraceae
#11
Caroline S Chaboo, Megan Biesele, Robert K Hitchcock, Andrea Weeks
The use of archery to hunt appears relatively late in human history. It is poorly understood but the application of poisons to arrows to increase lethality must have occurred shortly after developing bow hunting methods; these early multi-stage transitions represent cognitive shifts in human evolution. This paper is a synthesis of widely-scattered literature in anthropology, entomology, and chemistry, dealing with San ("Bushmen") arrow poisons. The term San (or Khoisan) covers many indigenous groups using so-called 'click languages' in southern Africa...
2016: ZooKeys
https://www.readbyqxmd.com/read/27000241/regulation-of-p-glycoprotein-efflux-activity-by-z-guggulsterone-of-commiphora-mukul-at-the-blood-brain-barrier
#12
Hong-Bin Xu, Jing Yu, Lu-Zhong Xu, Jun Fu
The present study was to investigate whether Z-guggulsterone had the regulatory effect on the activity and expression of P-glycoprotein in rat brain microvessel endothelial cells (rBMECs) and in rat brain. Inorganic phosphate liberation assay, high performance liquid chromatography, and western blot analysis were performed to assess the P-glycoprotein ATPase activity, the accumulation of NaF and rhodamine 123, and P-glycoprotein and MRP1 expression. The results showed that Z-guggulsterone (0-100 μM) significantly enhanced basal P-glycoprotein ATPase activity in a concentration-dependent manner...
April 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/26879835/z-guggulsterone-negatively-controls-microglia-mediated-neuroinflammation-via-blocking-i%C3%AE%C2%BAb-%C3%AE-nf-%C3%AE%C2%BAb-signals
#13
Chao Huang, Jili Wang, Xu Lu, Wenfeng Hu, Feng Wu, Bo Jiang, Yong Ling, Rongrong Yang, Wei Zhang
Induction of pro-inflammatory factors is one of the characteristics of microglial activation and can be regulated by numerous active agents extracted from plants. Suppression of pro-inflammatory factors is beneficial to alleviate neuroinflammation. Z-guggulsterone, a compound extracted from the gum resin of the tree commiphora mukul, exhibits numerous anti-inflammatory effects. However, the role and mechanism of Z-guggulsterone in pro-inflammatory responses in microglia remains unclear. This study addressed this issue in in vitro murine microglia and in vivo neuroinflammation models...
April 21, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/26865743/comparative-anti-hyperlipidaemic-activity-of-nav%C3%A4-na-fresh-and-pur%C3%A4-%C3%A1-a-old-guggulu
#14
Kruti Yagneshkumar Vyas, Prashant Bedarkar, R Galib, Pradeep Kumar Prajapati
OBJECTIVE: Guggulu (Commiphora wightii [Arn.] Bhandari) is a well-known anti-hyperlipidaemic drug. Guggulsterones are active components of this drug which are responsible for this effect. The activity of Guggulu may depend upon its nature, fresh samples are recommended for their bṛhmaṇa (body mass increasing) effect; while lekhana (scarificant) effect is attributed to the old one. The comparative Anti-hyperlipidaemic activity of fresh and old samples has not been reported till date...
October 2015: Ancient Science of Life
https://www.readbyqxmd.com/read/26676322/effect-of-myrrh-and-thyme-on-trichinella-spiralis-enteral-and-parenteral-phases-with-inducible-nitric-oxide-expression-in-mice
#15
Rasha A H Attia, Abeer E Mahmoud, Haiam Mohammed Mahmoud Farrag, Rania Makboul, Mona Embarek Mohamed, Zedan Ibraheim
Trichinellosis is a serious disease with no satisfactory treatment. We aimed to assess the effect of myrrh (Commiphora molmol) and, for the first time, thyme (Thymus vulgaris L.) against enteral and encysted (parenteral) phases of Trichinella spiralis in mice compared with albendazole, and detect their effect on inducible nitric oxide synthase (iNOS) expression. Oral administration of 500 mg/kg of myrrh and thyme led to adult reduction (90.9%, 79.4%), while 1,000 mg/kg led to larvae reduction (79.6%, 71.3%), respectively...
December 2015: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/26669677/hplc-method-for-chemical-fingerprinting-of-guggul-commiphora-wightii-quantification-of-e-and-z-guggulsterones-and-detection-of-possible-adulterants
#16
Rida Ahmed, Yan-Hong Wang, Zulfiqar Ali, Troy J Smillie, Ikhlas A Khan
A reversed-phase high-performance liquid chromatography method was developed for the chemical fingerprinting of Commiphora wightii gum resin (guggul). This method was also used for the quantification of E- and Z-guggulsterones in different C. wightii gum resin samples. The analysis was conducted on a high-performance liquid chromatography system with a reversed-phase column using a gradient elution comprised of water and acetonitrile with 0.1% acetic acid, and a run time of 50 min at 38 °C. The calibration curve of E- and Z-guggulsterones showed good linearity with a standard correlation coefficient >0...
March 2016: Planta Medica
https://www.readbyqxmd.com/read/26666387/%C3%AE-bisabolene-a-sesquiterpene-from-the-essential-oil-extract-of-opoponax-commiphora-guidottii-exhibits-cytotoxicity-in-breast-cancer-cell-lines
#17
Syn Kok Yeo, Ahmed Y Ali, Olivia A Hayward, Daniel Turnham, Troy Jackson, Ifor D Bowen, Richard Clarkson
The essential oils from Commiphora species have for centuries been recognized to possess medicinal properties. Here, we performed gas chromatography-mass spectrometry on the essential oil from opoponax (Commiphora guidotti) and identified bisabolene isomers as the main constituents of this essential oil. Opoponax essential oil, a chemical component; β-bisabolene and an alcoholic analogue, α-bisabolol, were tested for their ability to selectively kill breast cancer cells. Only β-bisabolene, a sesquiterpene constituting 5% of the essential oil, exhibited selective cytotoxic activity for mouse cells (IC50 in normal Eph4: >200 µg/ml, MG1361: 65...
March 2016: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/26662188/14r-17s-20r-lupan-3-one-assignment-of-a-new-triterpene-structure-from-commiphora-wightii
#18
LETTER
Soni Thakur, Vijai K Agnihotri
No abstract text is available yet for this article.
May 2016: Magnetic Resonance in Chemistry: MRC
https://www.readbyqxmd.com/read/26656228/traditional-herbs-a-remedy-for-cardiovascular-disorders
#19
Subha Rastogi, Madan Mohan Pandey, A K S Rawat
BACKGROUND: Medicinal plants have been used in patients with congestive heart failure, systolic hypertension, angina pectoris, atherosclerosis, cerebral insufficiency, venous insufficiency and arrhythmia since centuries. A recent increase in the popularity of alternative medicine and natural products has revived interest in traditional remedies that have been used for the treatment of cardiovascular diseases. AIM: The purpose of this review is to provide updated, comprehensive and categorized information on the history and traditional uses of some herbal medicines that affect the cardiovascular system in order to explore their therapeutic potential and evaluate future research opportunities...
October 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26650757/-e-caryophyllene-and-%C3%AE-humulene-aedes-aegypti-oviposition-deterrents-elucidated-by-gas-chromatography-electrophysiological-assay-of-commiphora-leptophloeos-leaf-oil
#20
Rayane Cristine Santos da Silva, Paulo Milet-Pinheiro, Patrícia Cristina Bezerra da Silva, Alexandre Gomes da Silva, Marcia Vanusa da Silva, Daniela Maria do Amaral Ferraz Navarro, Nicácio Henrique da Silva
Aedes aegypti is responsible for the transmission of dengue, a disease that infects millions of people each year. Although essential oils are well recognized as sources of compounds with repellent and larvicidal activities against the dengue mosquito, much less is known about their oviposition deterrent effects. Commiphora leptophloeos, a tree native to South America, has important pharmacological properties, but the chemical profile and applicability of its essential oil in controlling the spread of the dengue mosquito have not been investigated...
2015: PloS One
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