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https://www.readbyqxmd.com/read/29746995/rising-trade-declining-stocks-the-global-gugul-commiphora-wightii-trade
#1
REVIEW
A B Cunningham, J A Brinckmann, R N Kulloli, U Schippmann
ETHNOPHARMACOLOGICAL RELEVANCE: Commiphora wightii is exploited in India and Pakistan for an oleo-resin (gum guggul) traditionally used in Ayurvedic, Siddha and Unani medical systems. Processed C. wightii oleo-resin products are exported from India to 42 countries, including re-export to Pakistan, for anti-inflammatory use and as an anti-inflammatory and an anti-obesity treatment considered to lower cholesterol and lipid levels. The C. wightii export trade has particular relevance to the European Union because Belgium, France, Germany, Hungary, Italy, the Netherlands, and United Kingdom are importing countries...
May 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29582665/commiphoratones-a-and-b-two-sesquiterpene-dimers-from-resina-commiphora
#2
Jia-Wang Liu, Ying Liu, Yong-Ming Yan, Jing Yang, Xi-Feng Lu, Yong-Xian Cheng
Two sesquiterpene dimers, commiphoratones A (1) and B (2), were isolated from Resina Commiphora. Their structures were elucidated by spectroscopic, computational, and crystallographic methods. Compounds 1 and 2 represent an unusual pattern of dimerization between two types of sesquiterpenes. Moreover, compound 1 has a saddle shape. The plausible biosynthetic pathway for 1 and 2 is presented. Bioassay showed that 1 and 2 significantly block lipid metabolism in a concentration-dependent manner.
March 27, 2018: Organic Letters
https://www.readbyqxmd.com/read/29533080/bioactive-sesquiterpenoids-and-steroids-from-the-resinous-exudates-of-commiphora-myrrha
#3
Chi-Yu Ge, Jun-Li Zhang
Chemical investigation of the resinous exudates of Commiphora myrrha has led to the isolation of four sesquiterpenes (1a/1b, 2, and 3), including one pair of new sesquiterpene enantiomers (1a/1b), one new racemic mixture 2, and two steroids (4 and 5). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1a/1b were determined by CD analysis. The antimigratory potential of compounds 1-5 were evaluated and compound 3 was found to inhibit human hepatocellular liver carcinoma HepG2 cell migration in dose-dependent manner...
March 13, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29530608/frankincense-and-myrrh-essential-oils-and-burn-incense-fume-against-micro-inhabitants-of-sacral-ambients-wisdom-of-the-ancients
#4
Milica Ljaljević Grbić, Nikola Unković, Ivica Dimkić, Peđa Janaćković, Milan Gavrilović, Olja Stanojević, Miloš Stupar, Ljubodrag Vujisić, Aleksa Jelikić, Slaviša Stanković, Jelena Vukojević
ETHNOPHARMACOLOGICAL RELEVANCE: Essential oils obtained from resins of Boswellia carteri Birdw. and Commiphora myrrha (Nees) Engl., commonly known as frankincense and true myrrh respectively, have been used extensively since 2800 BCE for the treatment of skin sores, wounds, teeth, inflammation, and urinary tract diseases in traditional medicine; for preparation of mummification balms and unguents; and also as incense and perfumes. Since ancient times, burning of frankincense and myrrh in places of worship for spiritual purposes and contemplation (a ubiquitous practice across various religions) had hygienic functions, to refine the smell and reduce contagion by purifying the indoor air...
March 9, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29526242/traditional-and-modern-aspects-of-hemorrhoid-treatment-in-iran-a-review
#5
REVIEW
Sahar Dehdari, Homa Hajimehdipoor, Somayeh Esmaeili, Rasool Choopani, Seyed Alireza Mortazavi
Hemorrhoidal disease is a prevalent anorectal condition which is generally not managed well with current pharmacologic interventions. However, in Iranian traditional medicine (ITM) there are numerous plants with hemorrhoid-healing properties. The present research assembled plants with hemorrhoid-healing properties in ITM; their related pharmacological effects, phytochemical constituents and mechanisms of action in the modern medicine were also gathered. For this purpose, leading ITM textbooks were searched for plants with hemorrhoid-healing effects...
March 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29430927/characterization-of-sesquiterpene-dimers-from-resina-commiphora-that-promote-adipose-derived-stem-cell-proliferation-and-differentiation
#6
Jia-Wang Liu, Ming-Yu Zhang, Yong-Ming Yan, Xiao-Yi Wei, Lu Dong, Yan-Xia Zhu, Yong-Xian Cheng
The new sesquiterpene dimers commiphoroids A-D (1-4) were isolated from Resina Commiphora, and their structures were assigned by spectroscopic methods and X-ray diffraction analysis. Compounds 1 and 2 are stereoisomers of putative [2 + 4]-cycloaddition reactions, and 3 is a trinorsesquiterpene dimer containing a 6/6/5/6/6/6 hexacyclic framework, while 4 possesses a 8-oxabicyclo[3.2.1]oct-6-ene skeletal core. Plausible biosynthetic pathways for 1-4 are proposed. Biochemical studies show that compound 1 promotes ca...
March 2, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29393680/comprehensive-metabolite-profiling-in-distinct-chemotypes-of-commiphora-wightii
#7
Anil Bhatia, Tusha Tripathi, Suruchi Singh, Hema Bisht, Hari M Behl, Raja Roy, Om P Sidhu
Commiphora wightii (Arn.) Bhandari, known as guggul, produces a medicinally important gum resin which is used extensively by Ayurvedic physicians to treat various ailments. However, most of the studies on C. wightii have been limited to its gum resin. Comprehensive metabolic profiling of leaves, stem and gum resin samples was undertaken to analyse aqueous and non-aqueous metabolites from three distinct chemotypes (NBRI-101, NBRI-102 and NBRI-103) shortlisted from different agro-climatic zones. GC-MS, HPLC and NMR spectroscopy were used for comprehensive metabolomics...
February 2, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29322010/beneficiary-effect-of-commiphora-mukul-ethanolic-extract-against-high-fructose-diet-induced-abnormalities-in-carbohydrate-and-lipid-metabolism-in-wistar-rats
#8
Ramesh Bellamkonda, Rasineni Karuna, Bongu Sasi Bhusana Rao, Ketham Haritha, Bengeppagari Manjunatha, Somavarapu Silpa, Desireddy Saralakumari
The present study was proposed to elucidate the effect of Commiphora mukul gum resin elthanolic extract treatment on alterations in carbohydrate and lipid metabolisms in rats fed with high-fructose diet. Male Wistar rats were divided into four groups: two of these groups (group C and C+CM) were fed with standard pellet diet and the other two groups (group F and F+CM) were fed with high fructose (66 %) diet. C. mukul suspension in 5% Tween-80 in distilled water (200 mg/kg body weight/day) was administered orally to group C+CM and group F+CM...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29228822/effects-of-an-herbal-combination-on-glycemic-control-and-lipid-profile-in-diabetic-women-a-randomized-double-blind-placebo-controlled-clinical-trial
#9
Reyhaneh Shokoohi, Saeed Kianbakht, Mohammad Faramarzi, Masoud Rahmanian, Farzaneh Nabati, Saeed Mehrzadi, Hasan Fallah Huseini
The present study was conducted to explore the efficacy and safety of a herbal combination in the treatment of women with hyperlipidemic type 2 diabetes. The herbal combination capsule (600 mg) contained Terminalia chebula fruit extract (200 mg), Commiphora mukul (200 mg), and Commiphora myrrha oleo-gum-resin (200 mg), and the placebo capsule contained 600 mg toast powder. The patients in one group took the herbal combination and those in the other group took placebo capsules 3 times a day for 3 months. In the herbal combination-treated patients, the fasting blood glucose, total cholesterol, and low-density lipoprotein cholesterol levels were decreased and hidh-density lipoprotein cholesterol levels was increased significantly at the endpoint compared with the placebo and baseline...
October 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29124622/medicinal-plants-with-antithrombotic-property-in-persian-medicine-a-mechanistic-review
#10
REVIEW
Zahra Memariani, Reihaneh Moeini, Shokooh Sadat Hamedi, Narjes Gorji, Seyyed Ali Mozaffarpur
Thrombosis is one of the major causes of morbidity and mortality in a wide range of vessels diseases. Due to the high prevalence of thromboembolic disorders investigations are being carried out on new antithrombotic agents with limited adverse side effects in which herbal medicines are considered as alternative remedies. Persian medicine (PM) as a traditional medicine has a good potential for pharmacotherapy based on its own principles and development of drugs via investigating PM literature. In PM manuscripts there are some concepts that express the management of blood clots and antithrombotic properties...
January 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28930280/chemical-composition-and-monoterpenoid-enantiomeric-distribution-of-the-essential-oils-from-apharsemon-commiphora-gileadensis
#11
Nativ Dudai, Alona Shachter, Prabodh Satyal, William N Setzer
Background:Commiphora gileadensis (Hebrew: apharsemon) has been used since Biblical times to treat various ailments, and is used today in the traditional medicine of some Middle Eastern cultures. Methods: The essential oils from the stem bark, leaves, and fruits of Commiphora gileadensis-collected at the Ein Gedi Botanical Garden, Israel-were obtained by hydrodistillation and analyzed by gas chromatography-mass spectrometry. In addition, the enantiomeric distributions of the monoterpenoids in the essential oils have been determined by chiral gas chromatography...
September 12, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28882548/pleistocene-fossil-woods-from-the-okote-member-site-fwjj-14-in-the-ileret-region-koobi-fora-formation-northern-kenya
#12
Marion K Bamford
On the eastern side of Lake Turkana in northern Kenya are extensive Plio-Pleistocene deposits containing a rich diversity of fossil mammals, hominins and flora within the radiometrically dated tuffaceous, lacustrine and fluvial sequence. Reconstruction of this landscape and paleoenvironment are part of an ongoing multinational and multidisciplinary human evolution project in the eastern Turkana Basin. Today there is a huge lake in the Rift Valley but it has fluctuated since the early Pliocene. Silicified wood is fairly common in some areas of the Koobi Fora Formation...
November 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/28725152/analysis-of-inorganic-and-organic-constituents-of-myrrh-resin-by-gc-ms-and-icp-ms-an-emphasis-on-medicinal-assets
#13
Syed Rizwan Ahamad, Abdul Rahman Al-Ghadeer, Raisuddin Ali, Wajhul Qamar, Suliman Aljarboa
The aim of the present investigation was to explore the constituents of the Arabian myrrh resin obtained from Commiphora myrrha. The organic and inorganic composition of the myrrh gum resin has been investigated using gas chromatography-mass spectrometry (GC-MS) and inductively coupled plasma-mass spectrometry (ICP-MS). Analysis executed by ICP-MS reveals the presence of various inorganic elements in significant amount in the myrrh resin. The elements that were found to be present in large amounts include calcium, magnesium, aluminum, phosphorus, chlorine, chromium, bromine and scandium...
July 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28626756/a-pilot-study-on-bioactive-constituents-and-analgesic-effects-of-myrliq%C3%A2-a-commiphora-myrrha-extract-with-a-high-furanodiene-content
#14
Antonio Germano, Andrea Occhipinti, Francesca Barbero, Massimo E Maffei
The analgesic properties of myrrh (Commiphora myrrha) have been known since ancient times and depend on the presence of bioactive sesquiterpenes with furanodiene skeletons. MyrLiq is a C. myrrha extract with a standardized content of curzerene, furanoeudesma-1,3-diene, and lindestrene (12.31 ± 0.05 g kg(-1), 18.84 ± 0.02 g kg(-1), and 6.23 ± 0.01 g kg(-1), resp.) and a high total furanodiene content (40.86 ± 0.78 g kg(-1)). A balanced sample of 95 female and 89 male volunteers (with ages ranging from 18 to older than 60 years) exhibiting different pain pathologies, including headache, fever-dependent pain, joint pain, muscle aches, lower back pain, and menstrual cramps, was divided into two groups...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28584486/estimation-of-guggulsterone-e-and-z-in-the-guggul-based-commercial-formulations-using-high-performance-thin-layer-chromatography
#15
Pramod Kumar Sairkar, Anjana Sharma, N P Shukla
BACKGROUND: Guggulsterone (GS) is a plant steroid and bioactive compound present in gum Guggul of Commiphora wightii. An Indian herbal medicine system "Ayurveda" has a long history of use of gum Guggul and plant extract of C. wightii as medicine for the treatment of various illnesses. Complex nature, low availability, and inconsistency of phytoconstituents make its analysis of difficult tasks. AIMS: In this work, six different Guggul-based herbal formulations were examined for estimation of GS and their isomers (E and Z) through high-performance thin-layer chromatography technique...
January 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/28582635/prenylated-flavonoids-from-commiphora-opobalsamum-stem-bark
#16
Ali A El-Gamal, Shaza M Al-Massarani, Wael M Abdel-Mageed, Amina El-Shaibany, Hassan M Al-Mahbashi, Omer A Basudan, Farid A Badria, Mansour S Al-Said, Maged S Abdel-Kader
A phytochemical study on the stem bark of Commiphora opobalsamum looking for cytotoxic compounds afforded eleven flavonoids, including six previously undescribed prenylated congeners, comophorin A-E, and comophoroside A. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Isolated compounds were biologically evaluated using in vitro cytotoxicity MTT-based assay against two cancer cell lines; namely human hepato-cellular carcinoma (HepG-2) and human breast adenocarcinoma (MCF-7)...
September 2017: Phytochemistry
https://www.readbyqxmd.com/read/28535783/in-vivo-effect-of-commiphora-swynnertonii-ethanolic-extracts-on-trypanosoma-congolense-and-selected-immunological-components-in-mice
#17
Yakob P Nagagi, Richard S Silayo, Claudius Luziga, Eliningaya J Kweka
BACKGROUND: The search for alternative trypanocidal compounds which can be available at affordable price is of paramount importance for control of trypanosomosis in human and animals. The current study evaluates the in vivo activity of ethanolic stem bark extracts on Trypanosoma congolense and selected immunological components in an inbred Swiss albino mouse model. METHODS: Groups of mice infected with T. congolense were treated with the stem bark extracts at a rate of 1000 mg/kg, 1500 mg/kg, and 2000 mg/kg, twice a day in one set and thrice a day in another setting for three days consecutively...
May 23, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28504430/variation-of-tsetse-fly-abundance-in-relation-to-habitat-and-host-presence-in-the-maasai-steppe-tanzania
#18
Anibariki Ngonyoka, Paul S Gwakisa, Anna B Estes, Happiness J Nnko, Peter J Hudson, Isabella M Cattadori
Human activities modify ecosystem structure and function and can also alter the vital rates of vectors and thus the risk of infection with vector-borne diseases. In the Maasai Steppe ecosystem of northern Tanzania, local communities depend on livestock and suitable pasture that is shared with wildlife, which can increase tsetse abundance and the risk of trypanosomiasis. We monitored the monthly tsetse fly abundance adjacent to Tarangire National Park in 2014-2015 using geo-referenced, baited epsilon traps. We examined the effect of habitat types and vegetation greenness (NDVI) on the relative abundance of tsetse fly species...
June 2017: Journal of Vector Ecology: Journal of the Society for Vector Ecology
https://www.readbyqxmd.com/read/28414157/commiphora-molmol-resin-attenuates-diethylnitrosamine-phenobarbital-induced-hepatocarcinogenesis-by-modulating-oxidative-stress-inflammation-angiogenesis-and-nrf2-are-ho-1-signaling
#19
Ayman M Mahmoud, Amr R Zaki, Manal E Hassan, Gomaa Mostafa-Hedeab
The objective of the current study was to investigate the possible chemopreventive activity of Commiphora molmol resin (myrrh) extract using a rat model of diethylnitrosamine (DEN)/phenobarbital (PB)-induced early stage hepatocarcinogenesis. Here, we pointed to the modulatory effect of myrrh on oxidative stress, angiogenesis, inflammation and nuclear factor (erythroid-derived 2)-like 2 (Nrf2). Hepatocarcinogenesis was induced in Wistar rats using DEN for initiation and PB as a promoting agent. The rats received 125 or 250 mg/kg C...
May 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28382194/wound-healing-activity-of-extracts-and-formulations-of-aloe-vera-henna-adiantum-capillus-veneris-and-myrrh-on-mouse-dermal-fibroblast-cells
#20
Samira Negahdari, Hamid Galehdari, Mahnaz Kesmati, Anahita Rezaie, Gholamreza Shariati
BACKGROUND: Among the most important factors in wound healing pathways are transforming growth factor beta1 and vascular endothelial growth factor. Fibroblasts are the main cell in all phases wound closure. In this study, the extracts of plant materials such as Adiantum capillus-veneris, Commiphora molmol, Aloe vera, and henna and one mixture of them were used to treatment of normal mouse skin fibroblasts. METHODS: Cytotoxic effects of each extract and their mixture were assessed on mouse skin fibroblasts cells using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay...
2017: International Journal of Preventive Medicine
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