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https://www.readbyqxmd.com/read/28671103/effects-of-codonopsis-pilosula-water-extract-on-microrna-expression-profile-in-d-galactose-induced-senile-mice
#1
Jianguang Cai, Muhammad Aqeel Ashraf, Limei Luo, Hui Tang
This paper aims to observe and analyze effects of Codonopsis pilosula water extract on micro RNA (miRNA) expression profile in liver tissue of senile mice. The 110 Konminmice were randomly divided into five groups, including D-galactose-induced senile model group, normal control group, and low, middle and high dose intervention groups. Continuous modeling lasted 40 days. General symptoms and changes of body mass of the model mice were monitored and observed. The levels of serum glutamic pyruvic transaminase (ALT) and alkaline phosphatase (ALP) of mice were compared, and miRNA of differential expression during aging of D-galactose-induction and high-dose Codonopsis pilosula intervention was analyzed...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28660450/evaluating-water-deficit-and-glyphosate-treatment-on-the-accumulation-of-phenolic-compounds-and-photosynthesis-rate-in-transgenic-codonopsis-lanceolata-siebold-zucc-trautv-over-expressing-%C3%AE-tocopherol-methyltransferase-%C3%AE-tmt-gene
#2
Bimal Kumar Ghimire, Na-Young Son, Seung-Hyun Kim, Chang Yeon Yu, Ill-Min Chung
The effect of water stress and herbicide treatment on the phenolic compound concentration and photosynthesis rate in transgenic Codonopsis lanceolata plants over-expressing the γ-tmt gene was investigated and compared to that in control non-transgenic C. lanceolata plants. The total phenolic compound content was investigated using high-performance liquid chromatography combined with diode array detection in C. lanceolata seedlings 3 weeks after water stress and treatment with glyphosate. Changes in the composition of phenolic compounds were observed in leaf and root extracts from transformed C...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28600205/structural-characterization-of-a-pectic-polysaccharide-from-codonopsis-pilosula-and-its-immunomodulatory-activities-in-vivo-and-in-vitro
#3
Pei Zhang, Linhai Hu, Ruibin Bai, Xiaoping Zheng, Yuling Ma, Xia Gao, Bolu Sun, Fangdi Hu
A pectic polysaccharide (named as CPP1c) extracted from Codonopsis pilosula was evaluated for its structural features and potential of immune-modulating activities in an aging mouse model of senescence accelerated mouse prone 8 (SAMP8) in vitro and in vivo. The relative molecular weight and the absolute molecular weight of CPP1c were 1.26×10(5)Da and 1.49×10(5)Da, respectively. Investigation of structural features by a combination of chemical and instrumental analysis showed CPP1c was composed of →1)-α-L-Rhap-(2,4→, →1)-α-L-Araf-(5→, →1)-α-D-Galp-(6→ and →1)-α-D-GalpA-(4→ in a molar ratio of 3:1:2:33...
June 6, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28527988/codonopsis-lanceolata-polysaccharide-clps-inhibits-melanoma-metastasis-via-regulating-integrin-signaling
#4
Yanqiu Liu, Xiangming Zou, Guangren Sun, Yihong Bao
β1 integrin-mediated migration plays a fundamental role in melanoma metastasis. Here, we evaluated the molecular mechanisms underlying the anti-metastatic capacity of a polysaccharide fraction (CLPS) from Codonopsis lanceolata. CLPS inhibited in vivo melanoma metastasis in a B16F10 pulmonary metastasis model, impaired β1 integrin-mediated B16F10 melanoma cell migration in vitro evaluated by Transwell assay, reduced affinity between β1 integrin and ligand protein GST-FNIII9-10. Also, CLPS attenuated the adhesion-dependent formation of focal adhesion and blocked β1 integrin/FAK/paxillin signaling axis...
May 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28513535/characterization-of-chinese-unifloral-honeys-based-on-proline-and-phenolic-content-as-markers-of-botanical-origin-using-multivariate-analysis
#5
Ya-Qin Wen, Jinzhen Zhang, Yi Li, Lanzhen Chen, Wen Zhao, Jinhui Zhou, Yue Jin
The phenolic and proline content were determined in honey samples of different floral origins (rapeseed, sunflower, buckwheat and Codonopsis) from five different regions of China. The phenolic and proline profile of these samples were used to construct a statistical model to distinguish honeys from different floral origins. Significant differences were identified among the studied honey samples from multivariate chemometric methods. The proline content varied among the four types of honeys, with the values decreasing in the order: buckwheat > Codonopsis > sunflower > rapeseed...
May 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28471110/rapid-quantification-of-multi-components-in-alcohol-precipitation-liquid-of-codonopsis-radix-using-near-infrared-spectroscopy-nirs
#6
Yu Luo, Wen-Long Li, Wen-Hua Huang, Xue-Hua Liu, Yan-Gang Song, Hai-Bin Qu
A near infrared spectroscopy (NIRS) approach was established for quality control of the alcohol precipitation liquid in the manufacture of Codonopsis Radix. By applying NIRS with multivariate analysis, it was possible to build variation into the calibration sample set, and the Plackett-Burman design, Box-Behnken design, and a concentrating-diluting method were used to obtain the sample set covered with sufficient fluctuation of process parameters and extended concentration information. NIR data were calibrated to predict the four quality indicators using partial least squares regression (PLSR)...
May 2017: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/28339712/effect-of-chinese-herbal-medicine-treatment-on-plasma-lipid-profile-and-hepatic-lipid-metabolism-in-hetian-broiler
#7
Z Xie, J Zhang, S Ma, X Huang, Y Huang
The purpose of this study was to investigate whether adding a Chinese herbal hedicine (CHM, including astragalus membranaceus, codonopsis pilosula, poria cocos, bighead atractylodes rhizome, fructus crataegi, folium epimedii, radix saposhnikoviae, and pericarpium citri reticulatae) diet has effects on lipid metabolism in the liver of the broiler. Six-hundred-thirty Hetian broilers were divided into 3 groups including base diet (control), 0.3%, or 1% CHM diets, for 130 days. The results showed that CHM treatment significantly increased the slaughter performance...
June 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28254326/direct-electrochemistry-and-electrocatalysis-of-lobetyolin-via-magnetic-functionalized-reduced-graphene-oxide-film-fabricated-electrochemical-sensor
#8
Bolu Sun, Xiaodan Gou, Ruibin Bai, Ahmed Attia Ahmed Abdelmoaty, Yuling Ma, Xiaoping Zheng, Fangdi Hu
A novel lobetyolin electrochemical sensor based on a magnetic functionalized reduced graphene oxide/Nafion nanohybrid film has been introduced in this work. The magnetic functionalized reduced graphene oxide was characterized by fourier transform infrared spectroscopy, atomic force microscope, X-ray diffraction, transmission electron microscopy and thermogravimetric analysis. The scanning electron microscopy characterized the morphology and microstructure of the prepared sensors, and the electrochemical effective surface areas of the prepared sensors were also calculated by chronocoulometry method...
May 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28240886/codonopilate-a-a-triterpenyl-ester-as-main-autotoxin-in-cultivated-soil-of-codonopsis-pilosula-franch-nannf
#9
Min Xie, Zhiqiang Yan, Xia Ren, Xiuzhuang Li, Bo Qin
Codonopilate A (1), a triterpenyl ester, was isolated from monocultivated soil of annual Codonopsis pilosula and identified as the main autotoxin. The yield ratio of codonopilate A in dried soil was calculated as 2.04 μg/g. Other two triterpenoids, taraxeryl acetate (2) and 24-methylenecycloartanol (3), were isolated and identified as well showing weaker autotoxity. This was the first time that the potential allelochemicals and autotoxins in the cultivated soil of Codonopsis pilosula were reported. Accumulation of reactive oxygen species (ROS) induced by the autotoxins in the root tips of Codonopsis pilosula was considered as an important factor for the phytotoxic effect...
March 15, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28182623/evaluation-of-dna-barcodes-in-codonopsis-campanulaceae-and-in-some-large-angiosperm-plant-genera
#10
De-Yi Wang, Qiang Wang, Ying-Li Wang, Xiao-Guo Xiang, Lu-Qi Huang, Xiao-Hua Jin
DNA barcoding is expected to be one of the most promising tools in biological taxonomy. However, there have been no agreements on which core barcode should be used in plants, especially in species-rich genera with wide geographical distributions. To evaluate their discriminatory power in large genera, four of the most widely used DNA barcodes, including three plastid regions (matK, rbcL, trnH-psbA) and nuclear internal transcribed spacer (nrITS), were tested in seven species-rich genera (Ficus, Pedicularis, Rhodiola, Rhododendron,Viburnum, Dendrobium and Lysimachia) and a moderate size genus, Codonopsis...
2017: PloS One
https://www.readbyqxmd.com/read/27882072/radix-astragali-stimulates-p38-mark-phosphorylation-in-pediatric-patients-with-%C3%AE-thalassemia
#11
Zhuoming Lu, Xinhua Qian, Chunhong Zhang, Zhiwen Chen, Guangliang Du
A previous study conducted by our group demonstrated that Radix Astragali compounded with Codonopsis pilosula and Plastrum testudinis was effective in treating pediatric β-thalassemia in a randomized, controlled clinical trial. However, the mechanism of action that underpins this treatment remains to be elucidated. Blood was collected from patients participating in this clinical trial and nucleated red blood cell-enriched mononuclear cells were isolated to facilitate the extraction of RNA and protein. RT-PCR was used to monitor the expression of globin genes and p38 MAPK, and total and phosphorylated p38 MAPK expression was assessed using Western blot analysis...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27868250/effects-of-astragalus-membranaceus-codonopsis-pilosula-and-allicin-mixture-on-growth-performance-nutrient-digestibility-faecal-microbial-shedding-immune-response-and-meat-quality-in-finishing-pigs
#12
R X Lan, J W Park, D W Lee, I H Kim
A 12-week trial with 120 [(Landrace×Yorkshire)×Duroc] pigs (45.65 ± 1.93 kg) was conducted to evaluate the effects of Astragalus membranaceus, Codonopsis pilosula and allicin mixture (HM) supplementation on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. Pigs were allocated to one of three treatments with 0, 0.025% (HM1) and 0.05% (HM2) HM supplementation in a randomized complete block design according to sex and BW. Each treatment contained 10 replications with four pigs (two barrows and two gilts) per pen...
November 21, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27859496/application-of-a-solvent-free-solid-injection-technique-coupled-with-gc-ms-for-discrimination-between-the-secondary-metabolites-of-wild-and-cultivated-south-korean-medicinal-foods
#13
Lieu T B Truong, A M Abd El-Aty, Hyun Jin Kim, Md Musfiqur Rahman, Sung-Woo Kim, Ho-Chul Shin, Jae-Han Shim
Solvent-free solid injection was applied to differentiate between wild and cultivated South Korean medicinal foods, including dureup (Aralia elata), deodeok (Codonopsis lanceolata) and doraji (Platycodon grandiflorus). A number of compounds were identified in wild and cultivated dureup (53 and 46), deodeok (47 and 51) and doraji (43 and 38). Secondary metabolites, including butanal,2-methyl-, β-caryophyllene, neoclovene, α-humulene, γ-curcumene, β-bisabolene, and phytol, were identified in dureup with significantly (P < 0...
June 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27769400/a-novel-schiff-base-network-1-nanocomposite-coated-fiber-for-solid-phase-microextraction-of-phenols-from-honey-samples
#14
Wenchang Wang, Juntao Wang, Shuaihua Zhang, Penglei Cui, Chun Wang, Zhi Wang
A novel covalent organic framework, Schiff base network-1 (SNW-1), was synthesized and used as a solid-phase microextraction (SPME) fiber coating material. The SNW-1 coated SPME fiber was fabricated by a covalent chemical cross-linking between the SNW-1 nanocomposite and a silanol-functionalized stainless steel wire substrate. Scanning electron microscopy and nitrogen isothermal adsorption results indicate that the new fiber coating exhibited a porous, homogenous surface with the Brunauer-Emmett-Teller surface of 668m(2)g(-1)...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27768989/effects-of-astragalus-and-codonopsis-pilosula-polysaccharides-on-alveolar-macrophage-phagocytosis-and-inflammation-in-chronic-obstructive-pulmonary-disease-mice-exposed-to-pm2-5
#15
Xu Chu, Xiao-Ju Liu, Jing-Man Qiu, Xiao-Li Zeng, Hai-Rong Bao, Juan Shu
Astragalus and Codonopsis pilosula are used for their immunomodulatory and anti-inflammatory effects. Here, we investigated the effects of Astragalus polysaccharides (APS) and Codonopsis pilosula polysaccharides (CPP) on alveolar macrophage (AM) phagocytosis and inflammation in chronic obstructive pulmonary disease (COPD) associated with exposure to particulate matter with a mean aerodynamic diameter ≤2.5μm (PM2.5). A mouse model of COPD was established by cigarette smoke exposure. PM2.5 exposure was performed by inhalation of a PM2...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27745695/biologically-active-xanthones-from-codonopsis-ovata
#16
Alamgir A Dar, Nisar A Dangroo, Arun Raina, Arem Qayum, Shashank Singh, Anil Kumar, Payare L Sangwan
Five new xanthones, named coxanthones A-E (1-5), together with 21 known secondary metabolites (6-26) that include seven xanthones, five flavonoids, two steroids and seven triterpenoids were isolated from the chemically unexplored whole plant Codonopsis ovata. The structures of new metabolites were elucidated by HRMS, interpretation of NMR spectra and other spectroscopic techniques. The absolute configuration of the stereogenic centre of coxanthone B (2) was determined by electronic circular dichroism (ECD) spectroscopy...
December 2016: Phytochemistry
https://www.readbyqxmd.com/read/27723315/improved-growth-and-metabolite-accumulation-in-codonopsis-pilosula-franch-nannf-by-inoculation-of-bacillus-amyloliquefaciens-gb03
#17
Qi Zhao, Yong-Na Wu, Qin Fan, Qing-Qing Han, Paul W Paré, Rui Xu, Yin-Quan Wang, Suo-Min Wang, Jin-Lin Zhang
Codonopsis pilosula (Franch.) Nannf. is a traditional Chinese herbal medicinal plant and a low-cost succedaneum for Panax ginseng and contains various bioactivity components. In this work, we first evaluated the effects of the inoculation of the plant growth-promoting rhizobacteria Bacillus amyloliquefaciens strain GB03 on growth and metabolite accumulation of C. pilosula. The results demonstrated that application of B. amyloliquefaciens GB03 significantly improved the growth of C. pilosula compared to DH5α, Luria broth medium, and water treatment, respectively...
November 2, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27713010/phosphorylated-codonopsis-pilosula-polysaccharide-could-inhibit-the-virulence-of-duck-hepatitis-a-virus-compared-with-codonopsis-pilosula-polysaccharide
#18
Ke Ming, Yun Chen, Fangke Yao, Jintong Shi, Jingjing Yang, Hongxu Du, Xunyi Wang, Yixuan Wang, Jiaguo Liu
To screen effective anti-duck hepatitis A virus (DHAV) drugs, we applied STMP-STPP method to prepare phosphorylated Codonopsis pilosula polysaccharide (pCPPS), the phosphorylation-modified product of Codonopsis pilosula polysaccharide (CPPS). The IR spectrum and field emission scanning electron microscope (FE-SEM) were subsequently used to analyze the structure of pCPPS. Several tests were conducted to compare the anti-DHAV activities of CPPS and pCPPS. The MTT method was used to compare the effect of the drugs on DHAV-infected duck embryonic hepatocytes (DEHs), and the Reed-Muench assay was employed to observe changes in the virulence of DHAV...
January 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27698771/identification-of-the-protective-effects-of-traditional-medicinal-plants-against-sds-induced-drosophila-gut-damage
#19
Yang Zhou, Zonglin Liu, Yuchen Chen, Li Hua Jin
Traditional medicinal plants are widely used as immunomodulatory medicines that help improve health. A total of 50 different plants used for the treatment of toxicity were screened for their in vivo protective effects. Flies were fed a standard cornmeal-yeast medium (control group) or the standard medium containing medicinal plant extracts (experimental groups). Assessment of the survival rate was performed by feeding flies with toxic compounds. Gut epithelial cells were analyzed for cell proliferation and death by green fluorescent protein antibodies and 7-aminoactinomycin D staining under the microscope...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27641605/post-hematopoietic-stem-cell-transplantation-in-patients-with-hematologic-disorders-chinese-herbal-medicine-for-an-unmet-need
#20
REVIEW
Tom Fleischer, Tung-Ti Chang, Hung-Rong Yen
While much progress has been made in the field of hematopoietic stem cell transplantation (HSCT), headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chinese herbal medicine (CHM) for patients with hematologic disorders who received HSCT are gradually increasing; however, these data are mostly in Chinese. Therefore, we set out to summarize the existing data. We searched PubMed, the Cochrane Library and the China National Knowledge Infrastructure and retrieved 9 clinical studies related to this group of patients, in whom CHM was used as an intervention...
September 2016: Journal of Integrative Medicine
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