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https://www.readbyqxmd.com/read/27882072/radix-astragali-stimulates-p38-mark-phosphorylation-in-pediatric-patients-with-%C3%AE-thalassemia
#1
Zhuoming Lu, Xinhua Qian, Chunhong Zhang, Zhiwen Chen, Guangliang Du
A previous study conducted by our group demonstrated that Radix Astragali compounded with Codonopsis pilosula and Plastrum testudinis was effective in treating pediatric β-thalassemia in a randomized, controlled clinical trial. However, the mechanism of action that underpins this treatment remains to be elucidated. Blood was collected from patients participating in this clinical trial and nucleated red blood cell-enriched mononuclear cells were isolated to facilitate the extraction of RNA and protein. RT-PCR was used to monitor the expression of globin genes and p38 MAPK, and total and phosphorylated p38 MAPK expression was assessed using Western blot analysis...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27868250/effects-of-astragalus-membranaceus-codonopsis-pilosula-and-allicin-mixture-on-growth-performance-nutrient-digestibility-faecal-microbial-shedding-immune-response-and-meat-quality-in-finishing-pigs
#2
R X Lan, J W Park, D W Lee, I H Kim
A 12-week trial with 120 [(Landrace×Yorkshire)×Duroc] pigs (45.65 ± 1.93 kg) was conducted to evaluate the effects of Astragalus membranaceus, Codonopsis pilosula and allicin mixture (HM) supplementation on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. Pigs were allocated to one of three treatments with 0, 0.025% (HM1) and 0.05% (HM2) HM supplementation in a randomized complete block design according to sex and BW. Each treatment contained 10 replications with four pigs (two barrows and two gilts) per pen...
November 21, 2016: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/27859496/application-of-a-solvent-free-solid-injection-technique-coupled-with-gc-ms-for-discrimination-between-the-secondary-metabolites-of-wild-and-cultivated-south-korean-medicinal-foods
#3
Lieu T B Truong, A M Abd El-Aty, Hyun Jin Kim, Md Musfiqur Rahman, Sung Woo Kim, Ho-Chul Shin, Jae Han Shim
Solvent-free solid injection was applied to differentiate between wild and cultivated South Korean medicinal foods, including dureup (Aralia elata), deodeok (Codonopsis lanceolata), and doraji (Platycodon grandiflorus). A number of compounds were identified in wild and cultivated dureup (53 and 46), deodeok (47 and 51), and doraji (43 and 38). Secondary metabolites, including butanal,2-methyl-, β-caryophyllene, neoclovene, α-humulene, γ-curcumene, β-bisabolene, and phytol, were identified in dureup with significantly (P < 0...
November 15, 2016: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/27769400/a-novel-schiff-base-network-1-nanocomposite-coated-fiber-for-solid-phase-microextraction-of-phenols-from-honey-samples
#4
Wenchang Wang, Juntao Wang, Shuaihua Zhang, Penglei Cui, Chun Wang, Zhi Wang
A novel covalent organic framework, Schiff base network-1 (SNW-1), was synthesized and used as a solid-phase microextraction (SPME) fiber coating material. The SNW-1 coated SPME fiber was fabricated by a covalent chemical cross-linking between the SNW-1 nanocomposite and a silanol-functionalized stainless steel wire substrate. Scanning electron microscopy and nitrogen isothermal adsorption results indicate that the new fiber coating exhibited a porous, homogenous surface with the Brunauer-Emmett-Teller surface of 668m(2)g(-1)...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27768989/effects-of-astragalus-and-codonopsis-pilosula-polysaccharides-on-alveolar-macrophage-phagocytosis-and-inflammation-in-chronic-obstructive-pulmonary-disease-mice-exposed-to-pm2-5
#5
Xu Chu, Xiao-Ju Liu, Jing-Man Qiu, Xiao-Li Zeng, Hai-Rong Bao, Juan Shu
Astragalus and Codonopsis pilosula are used for their immunomodulatory and anti-inflammatory effects. Here, we investigated the effects of Astragalus polysaccharides (APS) and Codonopsis pilosula polysaccharides (CPP) on alveolar macrophage (AM) phagocytosis and inflammation in chronic obstructive pulmonary disease (COPD) associated with exposure to particulate matter with a mean aerodynamic diameter ≤2.5μm (PM2.5). A mouse model of COPD was established by cigarette smoke exposure. PM2.5 exposure was performed by inhalation of a PM2...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27745695/biologically-active-xanthones-from-codonopsis-ovata
#6
Alamgir A Dar, Nisar A Dangroo, Arun Raina, Arem Qayum, Shashank Singh, Anil Kumar, Payare L Sangwan
Five new xanthones, named coxanthones A-E (1-5), together with 21 known secondary metabolites (6-26) that include seven xanthones, five flavonoids, two steroids and seven triterpenoids were isolated from the chemically unexplored whole plant Codonopsis ovata. The structures of new metabolites were elucidated by HRMS, interpretation of NMR spectra and other spectroscopic techniques. The absolute configuration of the stereogenic centre of coxanthone B (2) was determined by electronic circular dichroism (ECD) spectroscopy...
October 10, 2016: Phytochemistry
https://www.readbyqxmd.com/read/27723315/improved-growth-and-metabolites-accumulation-in-codonopsis-pilosula-franch-nannf-by-inoculation-of-bacillus-amyloliquefaciens-gb03
#7
Qi Zhao, Yong-Na Wu, Qin Fan, Qing-Qing Han, Paul W Pare, Rui- Xu, Yin-Quan Wang, Suo-Min Wang, Jin-Lin Zhang
Codonopsis pilosula (Franch.) Nannf. is a traditional Chinese herbal medicinal plant and a low-cost succedaneum for Panax ginseng and contains all various of bioactivity components. In this work, we firstly evaluated the effects of the inoculation of the plant growth-promoting rhizobacteria Bacillus amyloliquefaciens strain GB03 on growth and metabolites accumulation of C. pilosula. The results demonstrated that application of B. amyloliquefaciens GB03 significantly improved the growth of C. pilosula compared to DH5α, LB medium and water treatment, respectively...
October 10, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27713010/phosphorylated-codonopsis-pilosula-polysaccharide-could-inhibit-the-virulence-of-duck-hepatitis-a-virus-compared-with-codonopsis-pilosula-polysaccharide
#8
Ke Ming, Yun Chen, Fangke Yao, Jintong Shi, Jingjing Yang, Hongxu Du, Xunyi Wang, Yixuan Wang, Jiaguo Liu
To screen effective anti-duck hepatitis A virus (DHAV) drugs, we applied STMP-STPP method to prepare phosphorylated Codonopsis pilosula polysaccharide (pCPPS), the phosphorylation-modified product of Codonopsis pilosula polysaccharide (CPPS). The IR spectrum and field emission scanning electron microscope (FE-SEM) were subsequently used to analyze the structure of pCPPS. Several tests were conducted to compare the anti-DHAV activities of CPPS and pCPPS. The MTT method was used to compare the effect of the drugs on DHAV-infected duck embryonic hepatocytes (DEHs), and the Reed-Muench assay was employed to observe changes in the virulence of DHAV...
October 3, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27698771/identification-of-the-protective-effects-of-traditional-medicinal-plants-against-sds-induced-drosophila-gut-damage
#9
Yang Zhou, Zonglin Liu, Yuchen Chen, Li Hua Jin
Traditional medicinal plants are widely used as immunomodulatory medicines that help improve health. A total of 50 different plants used for the treatment of toxicity were screened for their in vivo protective effects. Flies were fed a standard cornmeal-yeast medium (control group) or the standard medium containing medicinal plant extracts (experimental groups). Assessment of the survival rate was performed by feeding flies with toxic compounds. Gut epithelial cells were analyzed for cell proliferation and death by green fluorescent protein antibodies and 7-aminoactinomycin D staining under the microscope...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27641605/post-hematopoietic-stem-cell-transplantation-in-patients-with-hematologic-disorders-chinese-herbal-medicine-for-an-unmet-need
#10
REVIEW
Tom Fleischer, Tung-Ti Chang, Hung-Rong Yen
While much progress has been made in the field of hematopoietic stem cell transplantation (HSCT), headway in the promotion of recovery following this procedure has been limited. Data regarding the potential of Chinese herbal medicine (CHM) for patients with hematologic disorders who received HSCT are gradually increasing; however, these data are mostly in Chinese. Therefore, we set out to summarize the existing data. We searched PubMed, the Cochrane Library and the China National Knowledge Infrastructure and retrieved 9 clinical studies related to this group of patients, in whom CHM was used as an intervention...
September 2016: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/27566207/in-vitro-assays-suggest-shenqi-fuzheng-injection-has-the-potential-to-alter-melanoma-immune-microenvironment
#11
Juan DU, Brian Chi Yan Cheng, Xiu-Qiong Fu, Tao Su, Ting Li, Hui Guo, Su-Mei Li, Jin-Feng Wu, Hua Yu, Wen-Hua Huang, Hui Cao, Zhi-Ling Yu
ETHNOPHARMACOLOGICAL RELEVANCE: A modern agent Shenqi Fuzheng Injection (SFI), prepared from Codonopsis Radix and Astragali Radix, has been commonly used as a supplementary therapy for cancers including melanoma. This agent was derived from a formula documented in the "National Collection of Chinese Medicine Prescriptions". The formula has long been used as a remedy for Qi deficiency that is closely associated with cancer-related fatigue and poor quality of life. However, the antimelanoma mechanisms of SFI remain unclear...
August 23, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27497028/oxaliplatin-based-chemotherapy-combined-with-traditional-medicines-for-neutropenia-in-colorectal-cancer-a-meta-analysis-of-the-contributions-of-specific-plants
#12
REVIEW
Menghua Chen, Brian H May, Iris W Zhou, Daniel Man-Yuen Sze, Charlie C Xue, Anthony L Zhang
This review assessed the effects on chemotherapy induced neutropenia (CIN) of combining oxaliplatin regimens with traditional plant-based medicines (TMs) in the management of colorectal cancer (CRC). 32 RCTs (2224 participants) were included. Meta-analysis showed reduced incidence of grade 3/4 CIN (RR 0.45[0.31, 0.65], I(2)=0%). No studies reported serious adverse events or reduction in tumour response rates associated with concurrent use of oxaliplatin and TM. Due to small sample sizes and risk of bias, these results should be interpreted with caution...
September 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27313637/steamed-and-fermented-ethanolic-extract-from-codonopsis-lanceolata-attenuates-amyloid-%C3%AE-induced-memory-impairment-in-mice
#13
Jin Bae Weon, Min Rye Eom, Youn Sik Jung, Eun-Hye Hong, Hyun-Jeong Ko, Hyeon Yong Lee, Dong-Sik Park, Choong Je Ma
Codonopsis lanceolata (C. lanceolata) is a traditional medicinal plant used for the treatment of certain inflammatory diseases such as asthma, tonsillitis, and pharyngitis. We evaluated whether steamed and fermented C. lanceolata (SFC) extract improves amyloid-β- (Aβ-) induced learning and memory impairment in mice. The Morris water maze and passive avoidance tests were used to evaluate the effect of SFC extract. Moreover, we investigated acetylcholinesterase (AChE) activity and brain-derived neurotrophic factor (BDNF), cyclic AMP response element-binding protein (CREB), and extracellular signal-regulated kinase (ERK) signaling in the hippocampus of mice to determine a possible mechanism for the cognitive-enhancing effect...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27116989/effects-of-selenizing-codonopsis-pilosula-polysaccharide-on-macrophage-modulatory-activities
#14
Tao Qin, Zhe Ren, Dandan Lin, Yulong Song, Jian Li, Yufang Ma, Xuehan Hou, Yifan Huang
The purpose of the present study was to investigate the immune-enhancing activity of selenizing Codonopsis pilosula polysaccharide (sCPPS5) in nonspecific immune response. In in vitro experiment, the results showed that sCPPS5 could promote the phagocytic uptake, NO production, and TNF-α and IL-6 secretion of RAW264.7 cells. sCPPS5 could also strongly increase the IκB-α degradation in the cytosol and the translocation of NF-κB p65 subunit into the nucleus of RAW264.7 cells. In the vivo experiment, sCPPS5 at medium doses could significantly improve the phagocytic index of peritoneal macrophages and induce the secretion of TNF-α and IL-6...
August 28, 2016: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/27109245/two-new-polyacetylene-glycosides-from-the-roots-of-codonopsis-tangshen-oliv
#15
Jiayou Sun, Lun Wang, Mingkui Wang, Zhizhong Wang, Fu Li
Two new polyacetylene glycosides, tangshenyne A (1) and tangshenyne B (2), along with six known polyacetylenes were isolated from an 85% MeOH extract of the roots of Codonopsis tangshen Oliv. The chemical structures of the new compounds were determined on the basis of extensive spectroscopic analyses, including UV, IR, 1D and 2D NMR ((1)H-(1)H COSY, HSQC and HMBC) and HR-ESI-MS.
October 2016: Natural Product Research
https://www.readbyqxmd.com/read/27097416/-design-space-approach-to-optimize-first-ethanol-precipitation-process-of-dangshen
#16
Zhi-lin Xu, Wen-hua Huang, Xing-chu Gong, Tian-tian Ye, Hai-bin Qu, Yan-gang Song, Dong-lai Hu, Guo-xiang Wang
Design space approach is applied in this study to enhance the robustness of first ethanol precipitation process of Codonopsis Radix (Dangshen) by optimizing parameters. Total flavonoid recovery, dry matter removal, and pigment removal were defined as the process critical quality attributes (CQAs). Plackett-Burman designed experiments were carried out to find the critical process parameters (CPPs). Dry matter content of concentrated extract (DMCE), mass ratio of ethanol to concentrated extract (E/C ratio) and concentration of ethanol (CEA) were identified as the CPPs...
November 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/27095785/-inhibitory-effects-of-codonopsis-pilosula-polysaccharides-on-the-deterioration-of-impaired-phagocytosis-of-alveolar-macrophage-induced-by-fine-particulate-matter-in-chronic-obstructive-pulmonary-disease-mice
#17
X Chu, X J Liu, J M Qiu, X L Zeng, H R Bao
OBJECTIVE: To investigate the inhibitory effects of codonopsis pilosula polysaccharides (CPP) on the deterioration of impaired phagocytosis of alveolar macrophage (AM) induced by fine particulate matter with a mean aerodynamic diameter ≤2.5 μm (PM2.5) in chronic obstructive pulmonary disease (COPD) mice. METHODS: Sixty BALB/c male mice were randomly divided into control group, COPD group, PM2.5 group, PM2.5 COPD group, CPP COPD group and CPP+ PM2.5 COPD group...
April 12, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26983224/-correlation-analysis-between-physicochemical-properties-of-rhizosphere-soil-and-appearance-characters-of-codonopsis-pilosula-root-in-jiuzhaigou-county
#18
Er-hua Liao, Gang Du, Yuan-feng Zou, Xing-fu Chen, Jing-bo Zhang
OBJECTIVE: To study the physicochemical properties of rhizosphere soil and their influence on appearance characters of semi-natural cultivated Codonopsis pilosula root. METHODS: The comprehensive methods by combining outdoor investigating with indoor analyzing were applied. Rhizosphere soil samples and plant materials were collected from 35 collection points, the physicochemical properties of soil and the appearance characters of plant materials were investigated...
August 2015: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/26981095/neuroprotective-effect-of-shenqi-fuzheng-injection-pretreatment-in-aged-rats-with-cerebral-ischemia-reperfusion-injury
#19
Ying-Min Cai, Yong Zhang, Peng-Bo Zhang, Lu-Ming Zhen, Xiao-Ju Sun, Zhi-Ling Wang, Ren-Yan Xu, Rong-Liang Xue
Shenqi Fuzheng injection is extracted from the Chinese herbs Radix Astragali and Radix Codonopsis. The aim of the present study was to investigate the neuroprotective effects of Shenqi Fuzheng injection in cerebral ischemia and reperfusion. Aged rats (20-22 months) were divided into three groups: sham, model, and treatment. Shenqi Fuzheng injection or saline (40 mL/kg) was injected into the tail vein daily for 1 week, after which a cerebral ischemia/reperfusion injury model was established. Compared with model rats that received saline, rats in the treatment group had smaller infarct volumes, lower brain water and malondialdehyde content, lower brain Ca(2+) levels, lower activities of serum lactate dehydrogenase and creatine kinase, and higher superoxide dismutase activity...
January 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/26931614/codonopsis-lanceolata-a-review-of-its-therapeutic-potentials
#20
REVIEW
Muhammad Jahangir Hossen, Mi-Yeon Kim, Jong-Hoon Kim, Jae Youl Cho
Codonopsis lanceolata (Campanulaceae) is dicotyledonous herbaceous perennial plant, predominantly found in Central, East, and South Asia. This plant has been widely used in traditional medicine and is considered to have medicinal properties to treat diseases and symptoms such as bronchitis, coughs, spasm, psychoneurosis, cancer, obesity, hyperlipidemia, edema, hepatitis, colitis, and lung injury. C. lanceolata contains many biologically active compounds, including polyphenols, saponins, tannins, triterpene, alkaloids, and steroids, which contribute to its numerous pharmacological activities...
March 2016: Phytotherapy Research: PTR
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