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https://www.readbyqxmd.com/read/28694794/antivirulent-properties-of-underexplored-cinnamomum-tamala-essential-oil-and-its-synergistic-effects-with-dnase-against-pseudomonas-aeruginosa-biofilms-an-in-vitro-study
#1
Sanaulla Farisa Banu, Durairajan Rubini, Sairam Rakshitaa, Kamaraj Chandrasekar, Ramar Murugan, Aruni Wilson, Shanmugaraj Gowrishankar, Shunmugiah Karutha Pandian, Paramasivam Nithyanand
Pseudomonas aeruginosa is a nosocomial pathogen colonizing patients with chronic infectious diseases and has gained resistance to all the known broad spectrum antibiotics available today. The present study showcases the antibiofilm potential of an essential oil (EO) from an underexplored Cinnamomum species namely, C. tamala, against P. aeruginosa biofilms. Furthermore, the synergistic effects of the EO along with a commercially available DNase (DNaseI) and a DNase (MBD) isolated from a marine bacterium were explored for its antibiofilm activity...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28685911/combined-lifestyle-and-herbal-medicine-in-overweight-women-with-polycystic-ovary-syndrome-pcos-a-randomized-controlled-trial
#2
Susan Arentz, Caroline A Smith, Jason Abbott, Paul Fahey, Birinder S Cheema, Alan Bensoussan
Polycystic ovary syndrome (PCOS) is a common, complex reproductive endocrinopathy characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries. Lifestyle modification is a first-line intervention; however, there are barriers to success for this form of self-care, and women often seek adjunct therapies including herbal medicines. This pragmatic, randomized controlled trial, delivered in communities of Australia in overweight women with PCOS, compared the effectiveness and safety of a lifestyle intervention plus herbal medicine against lifestyle alone...
July 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28682072/caffeic-acid-phenethyl-ester-from-the-twigs-of-cinnamomum-cassia-inhibits-malignant-cell-transformation-by-inducing-c-fos-degradation
#3
Seung Ho Shin, Seoung Rak Lee, Eunjung Lee, Ki Hyun Kim, Sanguine Byun
The twigs of Cinnamomum cassia, commonly referred to as Cinnamomi Ramulus, are widely used as one of the primary ingredients in Chinese/Korean traditional medicines that have anticancer effects. However, the active constituents responsible for its anticancer effects and their molecular mechanisms still remain to be elucidated. Caffeic acid phenethyl ester (CAPE) and caffeic acid (CA) were isolated for the first time from C. cassia using LC-MS-guided phytochemical isolation methods. CAPE significantly suppressed EGF- and TPA-induced cell transformation of JB6 P+ cells at sub-micromolar concentrations, whereas CA, a structurally similar compound to CAPE, had no such effect...
July 6, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28665598/isolation-and-characterization-of-sesquiterpenoids-from-cassia-buds-and-their-antimicrobial-activities
#4
Yindengzhi Guoruoluo, Haofeng Zhou, Junfei Zhou, Haiqing Zhao, Haji Akber Aisa, Guangmin Yao
Cassia buds, the immature fruits of Cinnamomum cassia (Lauraceae), are widely consumed as a food spice, dietary supplements, flavoring agents, and preservatives. In this study, cassia buds were phytochemically investigated for the first time, leading to the isolation of 2 new sesquiterpenoids (1 and 2) and 10 known sesquiterpenoids (3-12). Their structures were determined by spectrometric and spectroscopic analyses, including nuclear magnetic resonance, high-resolution electrospray ionization mass spectrometry, and circular dichroism...
June 30, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28659036/cinnamomum-cassia-prevents-high-fat-diet-induced-obesity-in-mice-through-the-increase-of-muscle-energy
#5
Mi Young Song, Seok Yong Kang, Anna Kang, Ji Hye Hwang, Yong-Ki Park, Hyo Won Jung
The cortex of Cinnamomum cassia Presl (Cinnamomi Cortex: CC) has commonly been used for weight control in traditional medicines, but without a scientific basis. Therefore, this study was undertaken to investigate the anti-obesity effect of CC extract in a high-fat diet (HFD)-induced obese mouse model and in C2C12 mouse skeletal muscle cells. Male C57BL/6 mice were fed a normal diet or a HFD for 16 consecutive weeks, and orally administered CC extract (100 or 300[Formula: see text]mg/kg) or metformin (250[Formula: see text]mg/kg; positive control) daily for 16 weeks...
June 28, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28658798/anti-atherosclerotic-potential-of-aqueous-extract-of-cinnamomum-zeylanicum-bark-against-glucocorticoid-induced-atherosclerosis-in-wistar-rats
#6
Im Nagendra Nayak, Rajasekhar Chinta, Raghu Jetti
INTRODUCTION: Atherosclerosis is one of the major causes of disability of blood vessels which can result in development of many cardiovascular disorders. There is a strong association between atherosclerosis and insulin resistance and dyslipidemia. AIM: To study the anti-atherosclerotic potential of C. zeylanicum bark extract in insulin resistance associated atherosclerosis and worsened Atherogenic Index (AI) associated with dyslipidemia, which are the predominant complications of steroid diabetes in Wistar rats...
May 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28654013/in-vitro-anti-leishmanial-activity-of-essential-oils-extracted-from-vietnamese-plants
#7
Thanh Binh Le, Claire Beaufay, Duc Trong Nghiem, Marie-Paule Mingeot-Leclercq, Joëlle Quetin-Leclercq
Leishmania mexicana is one of the pathogens causing cutaneous leishmaniasis which is associated with patient morbidity. In our researches for new safe and effective treatments, thirty-seven essential oils (EOs) extracted from Vietnamese plants were screened in vitro for the first time on Leishmania mexicana mexicana(Lmm) promastigotes at the maximum concentration of 50 nL/mL. Active EOs were also analyzed for cytotoxicity on mammalian cell lines (WI38, J774) and their selectivity indices (SI) were calculated...
June 27, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28637123/inhibition-of-swarming-motility-of-pseudomonas-aeruginosa-by-methanol-extracts-of-alpinia-officinarum-hance-and-cinnamomum-tamala-t-nees-and-eberm
#8
Divya Lakshmanan, Jishudas Nanda, K Jeevaratnam
Bacterial drug resistance is a challenge in clinical settings, especially in countries like India. Hence, discovery of novel alternative therapeutics has become a necessity in the fight against drug resistance. Compounds that inhibit bacterial virulence properties form new therapeutic alternatives. Pseudomonas aeruginosa is an opportunistic, nosocomial pathogen that infects immune-compromised patients. Swarming motility is an important virulence property of Pseudomonas which aids it in reaching host cells under nutrient limiting conditions...
June 15, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28631137/assessment-of-titanium-dioxide-nanoparticles-tio2-nps-induced-hepatotoxicity-and-ameliorative-effects-of-cinnamomum-cassia-in-sprague-dawley-rats
#9
Muhammad Shakeel, Farhat Jabeen, Rehana Iqbal, Abdul Shakoor Chaudhry, Sadia Zafar, Muhammad Ali, Muhammad Saleem Khan, Adeel Khalid, Samina Shabbir, Muhammad Saleem Asghar
This study assessed the protective effects of Cinnamomum cassia (cinnamon) bark extract in rats exposed to titanium dioxide nanoparticles or titanium dioxide bulk salt. For in vivo evaluation of the ameliorative role of the cinnamon extract, the experimental groups were orally administered with the cinnamon extract at different dose levels (50 or 100 or 150 mg/kg bodyweight) along with the subcutaneous injections of 150 mg/kg bodyweight titanium dioxide nanoparticles or titanium dioxide bulk salt. The extract showed significant ameliorative role on the antioxidant system in response to elevated levels of titanium dioxide nanoparticles or titanium dioxide bulk salt-induced oxidative stress...
June 19, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28625892/consumers-acceptance-of-medicinal-herbs-an-application-of-the-technology-acceptance-model-tam
#10
Nargesh Khatun Jokar, Seyyed Ali Noorhosseini, Mohammad Sadegh Allahyari, Christos A Damalas
ETHNOPHARMACOLOGICAL RELEVANCE: The shift in consumers' preferences from synthetic to 'natural' products has led to a resurgence of interest in medicinal plants, particularly in developing countries. However, research data about consumers' preferences for particular products is hard to find. AIMS AND OBJECTIVES: The main objective of this study was to contribute to the general understanding of consumers' intention for selecting medicinal herbs for consumption. MATERIALS AND METHODS: Factors underpinning consumers' acceptance of medicinal herbs were studied with the technology acceptance model (TAM) in Rasht City of Iran using a structured questionnaire...
June 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28605974/hplc-method-for-measurement-of-human-salivary-%C3%AE-amylase-inhibition-by-aqueous-plant-extracts
#11
István Takács, Ákos Takács, Anikó Pósa, Gyöngyi Gyémánt
Control of hyperglycemia is an important treatment in metabolic disorders such as type II diabetes and obesity. α-Amylase, as the first enzyme of glucose release from dietary polysaccharides, is a potential target to identify new sources of novel anti-obesity and anti-diabetic drugs. In this work, different herbal extracts as α-amylase inhibitors were studied by measuring the rate of the cleavage of a maltooligomer substrate 2-chloro-4-nitrophenyl-β-D-maltoheptoside. Measurement of chromophore containing products after reversed phase HPLC separation was used for α-amylase activity measurement...
June 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28603113/nephroprotective-property-of-cinnamomum-zeylanicum-and-its-antibacterial-activity-in-combination-with-gantamicin
#12
Naveed Ullah, Mir Azam Khan, Salimullah Khan, - Roohullah, Abad Khan, Waqar Ahmad
Cinnamomum zeylanicum has strong antioxidant properties and has been presented to have nephroprotective effects. Present work was aimed to study the nephroprotective property of the plant extract through urinary enzymes excretion, to confirm its protective effects and to observe the antibacterial activities of gentamicin in combination with the plant extract. 200mg/kg/day of the plant extracts were administered alone and as co-therapy with gentamicin. Urinary lactate dehydrogenase (LDH) and Urinary alkaline phospatase (ALP) excretions were observed through reagents kits with the help of Power-Lab 300...
January 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28597443/phenologic-variation-of-major-triterpenoids-in-regular-and-white-antrodia-cinnamomea
#13
Wei-Lun Chen, Yen-Peng Ho, Jyh-Ching Chou
BACKGROUND: Antrodia cinnamomea and its host Cinnamomum kanehirae are both endemic species unique to Taiwan. Many studies have confirmed that A. cinnamomea is rich in polysaccharides and triterpenoids that may carry medicinal effects in anti-cancer, anti-inflammation, anti-hypertension, and anti-oxidation. Therefore it is of interest to study the chemical variation of regular orange-red strains and white strains, which included naturally occurring and blue-light induced white A. cinnamomea...
December 2016: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/28590026/efficient-approach-for-the-extraction-of-proanthocyanidins-from-cinnamomum-longepaniculatum-leaves-using-ultrasonic-irradiation-and-an-evaluation-of-their-inhibition-activity-on-digestive-enzymes-and-antioxidant-activity-in-vitro
#14
Zaizhi Liu, Kailin Mo, Shimin Fei, Yuangang Zu, Lei Yang
Proanthocyanidins were separated for the first time from Cinnamomum longepaniculatum leaves. An experiment-based extraction strategy was used to research the efficiency of an ultrasound-assisted method for proanthocyanidins extraction. The Plackett-Burman design results revealed that the ultrasonication time, ultrasonic power and liquid/solid ratio were the most significant parameters among the six variables in the extraction process. Upon further optimization of the Box-Behnken design, the optimal conditions were obtained as follows: extraction temperature, 100°C; ethanol concentration, 70%; pH 5; ultrasonication power, 660 W; ultrasonication time, 44 min; liquid/solid ratio, 20 mL/g...
June 7, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28583316/formulation-development-and-evaluation-of-antimicrobial-polyherbal-gel
#15
S D Bhinge, M A Bhutkar, D S Randive, G H Wadkar, S S Todkar, P M Kakade, P M Kadam
OBJECTIVE: In the recent years, there has been a gradual revival of interest in the use of medicinal plants in developing countries because herbal medicines have been reported safe with minimal adverse side effect especially when compared with synthetic drugs. METHOD: In the present study we prepared gel formulations (formulations A and B) which comprised of ethanolic extract of Azadirachta indica, Curcuma longa, Allium sativum, Ocimum sactum, Cinnamomum zeylanicum nees and Tamarindus indica in a concentration of 0...
June 2, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28566637/2-4-bis-1-1-dimethylethyl-phenol-from-cinnamomum-loureirii-improves-cognitive-deficit-cholinergic-dysfunction-and-oxidative-damage-in-tmt-treated-mice
#16
Cho Rong Kim, Soo Jung Choi, Jae Kyeom Kim, Chan Kyu Park, Min Chul Gim, Youn-Jung Kim, Gwi Gun Park, Dong-Hoon Shin
We previously reported that the extract of Cinnamomum loureirii (C. loureirii) significantly inhibited acetylcholinesterase (AChE), and identified 2,4-bis(1,1-dimethylethyl)phenol (BP) from C. loureirii as a potential AChE inhibitor. The present study, therefore was undertaken to demonstrate the effects of BP from C. loureirii on learning and memory impairment in trimethyltin (TMT)-treated ICR mice. Y-maze and passive avoidance tests were used to test cognitive ability. Further, changes in biochemical parameters in the brain tissue were also assessed in response to TMT injection and BP intervention...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28562338/an-herbal-formula-attenuates-collagen-induced-arthritis-via-inhibition-of-jak2-stat3-signaling-and-regulation-of-th17-cells-in-mice
#17
Xin Wu, Qiyang Shou, Cuiwei Chen, Hao Cai, Jida Zhang, Songqi Tang, Baochang Cai, Dongxin Tang, Gang Cao
Wenjinghuoluo prescription, a traditional Chinese medicine compound treatment of rheumatoid arthritis characterized by wind-cold-dampness arthralgia, contains five herbs, namely, C. cassia Presl., Cinnamomum cassia Presl., Paeonia lactiflora Pall., Saposhnikovia divaricate (Turcz.) Schischk., and Clematis chinensis Osbeck. We have reported that WJHL could inhibit the production of inflammatory mediators in immune cells. This study explored the effect and mechanism of WJHL on collagen-induced arthritis mice...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28556537/insecticidal-activities-of-their-components-derived-from-the-essential-oils-of-cinnamomum-sp-barks-and-against-ricania-sp-homoptera-ricaniidae-a-newly-recorded-pest
#18
Ye-Jin Jeon, Sang-Guei Lee, Young-Cheol Yang, Hoi Seon Lee
BACKGROUND: Insecticidal activities of Cinnamomum cassia and C. zeylanicum oils and their components are not known against Ricania sp. Insecticidal activities of major components derived from C. cassia and C. zeylanicum oils were examined in spray and leaf dipping bioassays against Ricania sp. nymphs and adults. RESULTS: LC50 value of C. cassia and C. zeylanicum oils was 37.66 and 72.62 mg/L, respectively, in the leaf dipping bioassays against Ricania sp. nymphs, and 77...
May 27, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28546803/effect-of-tribulus-terrestris-ginger-saffron-and-cinnamomum-on-menopausal-symptoms-a-randomised-placebo-controlled-clinical-trial
#19
Simin Taavoni, Neda Nazem Ekbatani, Hamid Haghani
Menopausal symptoms experienced by women vary widely, and while many women transition through menopause with manageable symptoms, others experience severe symptoms, which may impair their quality of life. The purpose of this study was to determine the effect of Tribulus terrestris, ginger, saffron, and Cinnamomum on menopausal symptoms. A randomised, triple-blind, controlled trial design was used for this study. The participants were 80 postmenopausal women aged 50-60 years. A demographic data form and the Menopause Rating Scale were used to collect data...
March 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28535060/cinnamomols-a-and-b-immunostimulative-diterpenoids-with-a-new-carbon-skeleton-from-the-leaves-of-cinnamomum-cassia
#20
Lei Zhou, Yali Tuo, Yi Hao, Xiaoman Guo, Wei Tang, Yongbo Xue, Junfen Zeng, Yu Zhou, Ming Xiang, Jianping Zuo, Guangmin Yao, Yonghui Zhang
Two diterpenoids with an unprecedented diterpene carbon skeleton, cinnamomols A (1) and B (2), were isolated from the leaves of Cinnamomum cassia. 1 and 2 feature a cage-like, rigid, 5/5/5/5/5/6-fused hexacyclic ring system. The structures of 1 and 2 were established by extensive spectroscopic techniques and single-crystal X-ray diffraction, and their plausible biosynthetic pathways were proposed. 1 and 2 exhibited significant in vitro immunostimulative activity, and the mode of action of 1 was investigated...
June 2, 2017: Organic Letters
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