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https://www.readbyqxmd.com/read/27910199/reverse-phase-compatible-tlc-bioautography-for-detection-of-tyrosinase-inhibitors
#1
Paula García, I Ayelen Ramallo, Ricardo L E Furlan
INTRODUCTION: Reverse phase chromatography and bioautographic assays are key tools for natural product bioguided isolation; however, their direct coupling has not been fully achieved. OBJECTIVES: To develop a bioautographic assay to detect tyrosinase inhibitors present in complex matrices sorbed on reverse phase (RP) TLC-plates that can be used for bioguided isolation of bioactive compounds. METHODS: Enzyme gel entrapment with an amphiphilic copolymer was used for assay development...
December 2, 2016: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/27894973/is-there-nothing-new-under-the-sun-the-influence-of-herbals-and-pharmacopoeias-on-ethnobotanical-traditions-in-albacete-spain
#2
Diego Rivera, Alonso Verde, Concepción Obón, Francisco Alcaraz, Candelaria Moreno, Teresa Egea, José Fajardo, José Antonio Palazón, Arturo Valdés, Maria Adele Signorini, Piero Bruschi
ETHNOPHARMACOLOGICAL RELEVANCE: This paper has two overarching aims: (1) presenting the results of studying the Albacete tariff of medicines of 1526 and (2) broadly analyzing the origin and influences of medicinal traditional knowledge in the region of Albacete, Spain. We use historical and modern literature that may have influenced this knowledge. Our primary goal was to determine the ingredients used in the pharmacy in the 16th century CE in Albacete through the analysis of the tariff, and our secondary goal was to investigate until when ingredients and uses present in pharmacy and herbals persisted in later periods...
November 25, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27869684/quantitative-structure-activity-relationship-of-cinnamaldehyde-compounds-against-wood-decaying-fungi
#3
Dongmei Yang, Hui Wang, Haijian Yuan, Shujun Li
Cinnamaldehyde, of the genius Cinnamomum, is a major constituent of the bark of the cinnamon tree and possesses broad-spectrum antimicrobial activity. In this study, we used best multiple linear regression (BMLR) to develop quantitative structure activity relationship (QSAR) models for cinnamaldehyde derivatives against wood-decaying fungi Trametes versicolor and Gloeophyllun trabeum. Based on the two optimal QSAR models, we then designed and synthesized two novel cinnamaldehyde compounds. The QSAR models exhibited good correlation coefficients: R²Tv = 0...
November 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27865616/phenylpropanoids-from-cinnamon-bark-reduced-%C3%AE-amyloid-production-by-the-inhibition-of-%C3%AE-secretase-in-chinese-hamster-ovarian-cells-stably-expressing-amyloid-precursor-protein
#4
Yu Jeong Kang, Dae-Gun Seo, So-Young Park
β-Amyloid (Aβ) is a substance of Alzheimer disease (AD), which is generated via the amyloidogenic pathway from amyloid precursor protein (APP) by β-secretase and γ-secretase. Inhibition of Aβ production is a potential therapeutic approach to AD. Thus, we tested the hypothesis that cinnamon bark (Cinnamomi Cortex Spissus), the dried bark of Cinnamomum cassia Blume (Lauraceae), and its constituents are beneficial to AD. The methanol extract of cinnamon bark efficiently reduced Aβ40 production in Chinese hamster ovarian (CHO) cells stably expressing APP as determined by enzyme-linked immunosorbent assay...
October 15, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27827950/tenuifolide-b-from-cinnamomum-tenuifolium-stem-selectively-inhibits-proliferation-of-oral-cancer-cells-via-apoptosis-ros-generation-mitochondrial-depolarization-and-dna-damage
#5
Chung-Yi Chen, Ching-Yu Yen, Hui-Ru Wang, Hui-Ping Yang, Jen-Yang Tang, Hurng-Wern Huang, Shih-Hsien Hsu, Hsueh-Wei Chang
The development of drugs that selectively kill oral cancer cells but are less harmful to normal cells still provide several challenges. In this study, the antioral cancer effects of tenuifolide B (TFB), extracted from the stem of the plant Cinnamomum tenuifolium are evaluated in terms of their effects on cancer cell viability, cell cycle analysis, apoptosis, oxidative stress, and DNA damage. Cell viability of oral cancer cells (Ca9-22 and CAL 27) was found to be significantly inhibited by TFB in a dose-responsive manner in terms of ATP assay, yielding IC50 = 4...
November 5, 2016: Toxins
https://www.readbyqxmd.com/read/27827929/the-chemical-composition-of-essential-oils-from-cinnamomum-camphora-and-their-insecticidal-activity-against-the-stored-product-pests
#6
Shanshan Guo, Zhufeng Geng, Wenjuan Zhang, Junyu Liang, Chengfang Wang, Zhiwei Deng, Shushan Du
To investigate the chemical composition and insecticidal activity of the essential oils of certain Chinese medicinal herbs and spices, the essential oils were extracted from the stem barks, leaves, and fruits of Cinnamomum camphora (L.) Presl, which were found to possess strong fumigant toxicity against Tribolium castaneum and Lasioderma serricorne adults. The essential oils of the plants were extracted by the method of steam distillation using a Clavenger apparatus. Their composition was determined by gas chromatography/mass spectrometric (GC-MS) analyses (HP-5MS column), and their insecticidal activity was measured by seal-spaced fumigation...
November 4, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27780753/the-essential-oil-from-the-twigs-of-cinnamomum-cassia-presl-alleviates-pain-and-inflammation-in-mice
#7
Lan Sun, Shao-Bo Zong, Jia-Chun Li, Yao-Zhong Lv, Li-Na Liu, Zheng-Zhong Wang, Jun Zhou, Liang Cao, Jun-Ping Kou, Wei Xiao
ETHNOPHARMACOLOGICAL RELEVANCE: Cinnamomum cassia Presl (Lauraceae) can be found southern China and its bark is commonly used for centuries as ingredient in food and cosmetic industry. The twigs of Cinnamomum cassia Presl is popularly used in China to treat inflammatory processes, pain, menstrual disorders, hypertension, fever etc. The aim of this study is to evaluate the antinociceptive and anti-inflammatory properties of the essential oil (EO) from the twigs of Cinnamomum cassia Presl...
October 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27774415/cinnamon-extract-lowers-glucose-insulin-and-cholesterol-in-people-with-elevated-serum-glucose
#8
Richard A Anderson, Zhiwei Zhan, Rencai Luo, Xiuhua Guo, Qingqing Guo, Jin Zhou, Jiang Kong, Paul A Davis, Barbara J Stoecker
Cinnamon ( ròu guì) has in vitro insulin potentiating activity, and proanthocyanidins from cinnamon prevent in vitro formation of advanced glycation end products. Some human studies were equivocal, but several have shown beneficial effects of cinnamon supplementation on circulating glucose, lipids, and/or insulin. This placebo-controlled double-blind trial tested the effects of a dried water extract of cinnamon (Cinnamomum cassia) on circulating glucose, lipids, insulin, and insulin resistance. Men and women from Beijing and Dalian, China, were invited to participate if they had fasting serum glucose >6...
October 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27771918/cinnamon-and-chronic-diseases
#9
Mitra Hariri, Reza Ghiasvand
Cinnamon (Cinnamomum zeylanicum and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family and is one of the most important spices used daily by people all over the world. It contains a lot of manganese, iron, dietary fiber, and calcium. Cinnamon contains derivatives, such as cinnamaldehyde, cinnamic acid, cinnamate, and numerous other components such as polyphenols and antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer effects. Several reports have dealt with the numerous properties of cinnamon in the forms of bark, essential oils, bark powder, and phenolic compounds, and each of these properties can play a key role in human health...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27770682/activity-of-essential-oil-based-microemulsions-against-staphylococcus-aureus-biofilms-developed-on-stainless-steel-surface-in-different-culture-media-and-growth-conditions
#10
Campana Raffaella, Luca Casettari, Laura Fagioli, Marco Cespi, Giulia Bonacucina, Wally Baffone
Food safety is a fundamental concern for both consumers and the food industry, especially as the numbers of reported cases of food-associated infections continue to increase. Industrial surfaces can provide a suitable substrate for the development and persistence of bacterial organized in biofilms that represent a potential source of food contamination. The negative consumer perception of chemical disinfectants has shifted the attention to natural substances, such as plant extracts. The aim of this study was to investigate the possibility of using the essential oils (EOs) in the fight against S...
October 17, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27742359/fumigant-and-contact-toxicity-of-22-wooden-essential-oils-and-their-major-components-against-drosophila-suzukii-diptera-drosophilidae
#11
Junheon Kim, Miyeon Jang, Eunsik Shin, Jeongmin Kim, Si Hyeock Lee, Chung Gyoo Park
Fumigant and contact toxicities of 22 plant essential oils (EOs) from 14 families and their constituents against the adult spotted wing drosophila (SWD), Drosophila suzukii were examined. Analyses by GC, GC-MS, and NMR led to the identification of 2, 16, 13, 4, 6, 9, and 10 compounds from Gaultheria fragrantissima, Croton anistatum, Illicium verum, Liquidamabar orientalis, Cinnamomum cassia, Rosa damasena, and Santalum album, respectively. In fumigant toxicity test, G. fragrantissima, C. anistatum, and I. verum exhibited 100, 93...
October 2016: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/27739321/variation-in-volatile-constituents-of-cinnamomum-keralaense-endemic-to-the-western-ghats-india
#12
Venkatraman Sriramavaratharajan, Jeyamary Stephan, Veerappan Sudha, Ramar Murugan
Leaf essential oils (EOs) of Cinnamomum keralaense, an endemic species to Southern Western Ghats, India, were investigated. Leaves were collected from three distinct populations and hydro-distilled to obtain EOs, which were analysed by GC-FID and GC-MS. A total of 68 constituents was identified from three EOs. Wide variation was found in the composition of EOs. Ten major compounds were identified from three EOs, however, none of the compound was present in all three EOs as major constituent. High content of methyl eugenol (82...
October 14, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27721543/anxiolytic-antidepressant-and-antistress-activities-of-the-aqueous-extract-of-cinnamomum-tamala-nees-and-eberm-in-rats
#13
Gayaprasad Upadhyay, Sarvesh Khoshla, Ramoji Kosuru, Sanjay Singh
OBJECTIVE: The current study was designed to explore anxiolytic, antidepressant, and antistress actions of Cinnamomum tamala (CT) leaves (aqueous extract) in rats. MATERIALS AND METHODS: Behavioral procedures of anxiety, depression, and stress were assessed in rats. CT (100, 200, and 400 mg/kg) was given once a daily for 7 days via oral route and the efficacy was matched by those elicited by lorazepam (1 mg/kg, p.o.), imipramine (10 mg/kg, p.o.), and Withania somnifera (100 mg/kg, p...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27720465/inhibition-of-aryl-hydrocarbon-receptor-signaling-and-induction-of-nrf2-mediated-antioxidant-activity-by-cinnamaldehyde-in-human-keratinocytes
#14
Hiroshi Uchi, Mao Yasumatsu, Saori Morino-Koga, Chikage Mitoma, Masutaka Furue
BACKGROUND: Dioxins and other environmental pollutants are toxic and remain in biological tissues for a long time leading to various levels of oxidative stress. Although the toxicity of these agents has been linked to activation of the aryl hydrocarbon receptor (AHR), no effective treatment has been developed. OBJECTIVE: To explore novel phytochemicals that inhibit AHR activation in keratinocytes. METHODS: Keratinocytes were used in this study because the skin is one of the organs most affected by dioxin and other environmental pollutants...
October 4, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/27690641/chemical-constituents-of-cinnamomum-septentrionale-leaf-litter-and-its-allelopathic-activity-on-the-growth-of-maize-zea-mays
#15
Shanshan Yang, Hongling Hu, Tingxing Hu, Qian Wang, Mao Ye, Jie Luo, Yong Peng, Ruyi Zhang
A pot experiment was conducted to study the effect of decomposing Cinnamomum septentrionale leaf litter on the growth of maize. In this study, the morphological traits of maize were significantly inhibited when the leaf litter amount reached or exceeded 40 g per pot; Furthermore, during the early growth stage or with a large amount of litter addition, the pigment contents were inhibited by C. septentrionale leaf litter. Gas chromatography-mass spectrometry was used to determine the volatile substances of leaf litter and 34 compounds were identified, several of which were reported to be phytotoxic...
October 3, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27679615/antimicrobial-activity-and-mechanism-of-inhibition-of-silver-nanoparticles-against-extreme-halophilic-archaea
#16
Rebecca S Thombre, Vinaya Shinde, Elvina Thaiparambil, Samruddhi Zende, Sourabh Mehta
Haloarchaea are salt-loving halophilic microorganisms that inhabit marine environments, sea water, salterns, and lakes. The resistance of haloarchaea to physical extremities that challenge organismic survival is ubiquitous. Metal and antibiotic resistance of haloarchaea has been on an upsurge due to the exposure of these organisms to metal sinks and drug resistance genes augmented in their natural habitats due to anthropogenic activities and environmental pollution. The efficacy of silver nanoparticles (SNPs) as a potent and broad spectrum inhibitory agent is known, however, there are no reports on the inhibitory activity of SNPs against haloarchaea...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27676384/evaluation-of-the-wound-healing-efficacy-of-chemical-and-phytogenic-silver-nanoparticles
#17
Sreevani Pothireddy, Adilaxmamma Kaliki, Alpha Raj Mekapogu, Muralidhar Yegireddy, Eswara Prasad Pagadala, Tollamadugu Naga Venkata Krishna Vara Prasad
Wound healing requires a series of cellular events and a cascade of co-ordinated and systemic biochemical events. Silver nanoparticles possess many beneficial properties for wound management including antibacterial, anti-inflammatory and pro-healing properties. In this study, the authors investigated the wound healing properties of Cinnamomum verum extract mediated nanosilver (CENS) particles in comparison with 1% povidone iodine, citrate mediate NS and CE treatments. The topical application of CENS showed good antibacterial activity and accelerated wound healing with complete epithelialisation and normal re-growth of hair in all three models of study: namely, excision, incision and dead space models in rats compared with all other treatments...
October 2016: IET Nanobiotechnology
https://www.readbyqxmd.com/read/27651812/the-effect-of-cinnamomum-zeylanicum-bark-water-extract-on-memory-performance-in-alloxan-induced-diabetic-mice
#18
Azadeh Mesripour, Fatemeh Moghimi, Mahmoud Rafieian-Kopaie
Cinnamomum zeylanicum (cinnamon) has a wide range of beneficial effects including mild glucose lowering activity. The aim of the present study was to investigate whether cinnamon bark extract has the potential to improve memory performance and glucose profiles in diabetic mice. Memory was assessed by the novel object recognition task in male Balb/c mice. In this method, the difference between exploration time of a familiar object and a novel object was considered as an index of memory performance (recognition index, RI)...
July 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27639472/pahs-uptake-and-translocation-in-cinnamomum-camphora-leaves-from-shanghai-china
#19
Bo Yang, Sai Liu, Ying Liu, Xiaofei Li, Xianbiao Lin, Min Liu, Xinran Liu
Foliage uptake and inner-leaf translocation of polycyclic aromatic hydrocarbons (PAHs) by Cinnamomum camphora from different urbanized areas were comparatively investigated in this study. Spatial and seasonal variations of ∑16PAHs in leaves were observed, likely due to the diversity of leaf wax contents sampled in different seasons and locations. A negative correlation between the wax contents and ∑16PAHs concentrations in the cuticular wax was observed. The low values of TFf-m (translocation factor from foliar dust to mesophyll) indicated a poor translocation ability of PAHs from the foliar dust to the mesophyll...
September 15, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27620825/effect-of-sodium-alginate-coating-incorporated-with-nisin-cinnamomum-zeylanicum-and-rosemary-essential-oils-on-microbial-quality-of-chicken-meat-and-fate-of-listeria-monocytogenes-during-refrigeration
#20
Mojtaba Raeisi, Alijan Tabaraei, Mohammad Hashemi, Nasser Behnampour
The present study was conducted to preserve the microbial quality of chicken meat fillets during storage time by using sodium alginate active coating solutions incorporated with different natural antimicrobials including nisin, Cinnamomum zeylanicum (cinnamon), and rosemary essential oils (EOs) which were added individually and in combination. The samples were stored in refrigeration condition for 15days and were analyzed for total viable count, Enterobacteriaceae count, lactic acid bacteria count, Pseudomonas spp...
December 5, 2016: International Journal of Food Microbiology
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