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https://www.readbyqxmd.com/read/29463877/cinnamaldehyde-accelerates-wound-healing-by-promoting-angiogenesis-via-up-regulation-of-pi3k-and-mapk-signaling-pathways
#1
Xing Yuan, Lin Han, Peng Fu, Huawu Zeng, Chao Lv, Wanlin Chang, R Scott Runyon, Momoko Ishii, Liwen Han, Kechun Liu, Taiping Fan, Weidong Zhang, Runhui Liu
The bark of Cinnamomum cassia (C. cassia) has been used for the management of coronary heart disease (CHD) and diabetes mellitus. C. cassia may target the vasculature, as it stimulates angiogenesis, promotes blood circulation and wound healing. However, the active components and working mechanisms of C. cassia are not fully elucidated. The Shexiang Baoxin pill (SBP), which consists of seven medicinal materials, including C. cassia etc., is widely used as a traditional Chinese patent medicine for the treatment of CHD...
February 20, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29456868/-cinnamomum-zeylanicum-bark-essential-oil-induces-cell-wall-remodelling-and-spindle-defects-in-candida-albicans
#2
Zinnat Shahina, Amira M El-Ganiny, Jessica Minion, Malcolm Whiteway, Taranum Sultana, Tanya E S Dahms
Background: Cinnamon ( Cinnamomum zeylanicum) bark extract exhibits potent inhibitory activity against Candida albicans but the antifungal mechanisms of this essential oil remain largely unexplored. Results: We analyzed the impact of cinnamon bark oil on C. albicans RSY150, and clinical strains isolated from patients with candidemia and candidiasis. The viability of RSY150 was significantly compromised in a dose dependent manner when exposed to cinnamon bark oil, with extensive cell surface remodelling at sub inhibitory levels (62...
2018: Fungal Biology and Biotechnology
https://www.readbyqxmd.com/read/29454355/temporal-changes-of-fine-root-overyielding-and-foraging-strategies-in-planted-monoculture-and-mixed-forests
#3
Weiwei Shu, Xiaoxiao Shen, Pifeng Lei, Wenhua Xiang, Shuai Ouyang, Wende Yan
BACKGROUND: Mixed forests are believed to enhance ecosystem functioning and sustainability due to complementary resource use, environmental benefits and improved soil properties. The facilitation between different species may induce overyielding. Meanwhile, the species-specific fine root foraging strategies and tradeoffs would determine the structure and dynamics of plant communities. Here the aim was to investigate the admixing effects of fine-root biomass, vertical distribution and morphology in Pinus massoniana-Cinnamomum camphora mixed plantations and corresponding monocultures at 10-, 24- and 45-year old stands...
February 17, 2018: BMC Ecology
https://www.readbyqxmd.com/read/29429331/investigation-of-lipid-metabolism-by-a-new-structured-lipid-with-medium-and-long-chain-triacylglycerols-from-cinnamomum-camphora-seed-oil-in-healthy-c57bl-6j-mice
#4
Jiang-Ning Hu, Jin-Rong Shen, Chao-Yue Xiong, Xue-Mei Zhu, Ze-Yuan Deng
In the present study, a new structured lipid with medium- and long-chain triacylglycerols (MLCTs) was synthesized from camellia oil (CO) and Cinnamomum camphora seed oil (CCSO) by enzymatic interesterification. Meanwhile, the antiobesity effects of structured lipid were investigated through observing the changes of enzymes related to lipid mobilization in healthy C57BL/6J mice. Results showed that after synthesis, the major triacylgeride (TAG) species of intesterificated product changed to LaCC/CLaC (12.6 ± 0...
February 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29417554/toxicity-and-growth-inhibition-potential-of-vetiver-cinnamon-and-lavender-essential-oils-and-their-blends-against-larvae-of-the-sheep-blowfly-lucilia-sericata
#5
Hanem F Khater, Ali M Ali, Galal A Abouelella, Marawan A Marawan, Marimuthu Govindarajan, Kadarkarai Murugan, Rao Z Abbas, Nelissa P Vaz, Giovanni Benelli
BACKGROUND: Myiasis induced by the sheep blowfly, Lucilia sericata, represents a public health problem widely distributed throughout the world. L. sericata larval stages feed on both humans and animals. L. sericata adults and larvae can play a role in spreading agents of mycobacterial infections. OBJECTIVES: It is critical to establish new and safe alternative methods of controlling L. sericata. METHODS: The insecticidal effectiveness and growth inhibition potential of three commercially available essential oils (EOs), vetiver (Chrysopogon zizanioides), cinnamon (Cinnamomum zeylanicum), and lavender (Lavandula angustifolia), as well as their blends, were tested against the second (L2) and third (L3) larval stages of L...
February 8, 2018: International Journal of Dermatology
https://www.readbyqxmd.com/read/29408310/phytochemical-characterization-biological-activity-evaluation-of-ethanolic-extract-of-cinnamomum-zeylanicum-and-molecular-docking-analysis-of-active-component-cinnamaldehyde-against-selected-protein-targets
#6
Ishrat Husain, Rumana Ahmad, Anu Chandra, Syed Tasleem Raza, Yogeshwer Shukla, Farzana Mahdi
ETHNOPHARMACOLOGICAL RELEVANCE: India being a multicultural nation, every region of the country offers a distinct culinary flavor and taste. These flavours are attributed to spices and condiments which form the mainstay of Indian cuisine. Most of these spices and condiments are derived from various biodiversity hotspots in India and form the crux of India's multidiverse and multicultural cuisine. Apart from their varying aromas, flavors and tastes, these spices and condiments are known to possess several medicinal properties also...
February 2, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29389560/selected-essential-oils-inhibit-key-physiological-enzymes-and-possess-intracellular-and-extracellular-antimelanogenic-properties-in%C3%A2-vitro
#7
Zaahira Aumeeruddy-Elalfi, Namrita Lall, Bianca Fibrich, Analike Blom van Staden, Muzzammil Hosenally, Mohamad Fawzi Mahomoodally
Essential oils (EOs) extracted from six medicinal herbs and food plants [Cinnamomum zeylanicum (CZ), Psiadia arguta (PA), Psiadia terebinthina (PT), Citrus grandis (CGp), Citrus hystrix (CH), and Citrus reticulata (CR)] were studied for any inhibitory potential against key physiological enzymes involved in diabetes (α-glucosidase), skin aging (collagenase and elastase), and neurodegenerative disorders (acetylcholinesterase). Kinetic studies of the active EOs on the aforementioned enzymes were determined using Lineweaver-Burk plots...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29389558/anti-inflammatory-effect-of-cinnamaldehyde-and-linalool-from-the-leaf-essential-oil-of-cinnamomum-osmophloeum-kanehira-in-endotoxin-induced-mice
#8
Shih-Chieh Lee, Shih-Yun Wang, Chien-Chun Li, Cheng-Tzu Liu
Cinnamomum osmophloeum Kanehira is a Taiwan native plant that belongs to genus Cinnamomum and is also known as pseudocinnamomum or indigenous cinnamon. Its leaf is traditionally used by local people in cooking and as folk therapy. We previously demonstrated the chemical composition and anti-inflammatory effect of leaf essential oil of Cinnamomum osmophloeum Kanehira of linalool chemotype in streptozotocin-induced diabetic rats and on endotoxin-injected mice. The aim of the present study is to evaluate whether cinnamaldehyde and linalool the active anti-inflammatory compounds in leaf essential oil of Cinnamomum osmophloeum Kanehira...
January 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29358557/cinnamomum-osmophloeum-kanehira-ethanol-extracts-prevents-human-liver-derived-hepg2-cell-death-from-oxidation-stress-by-induction-of-ghrelin-gene-expression
#9
Shu-Ying Liu, Chih-Hao Huang, Jia-Ching Shieh, Tai-Lin Lee
Diabetes patients associated with liver disease carry a significant risk of morbidity and mortality. Cinnamon has been reported to reduce fructose-induced oxidative stress in the rat liver. However, the mechanism by which cinnamon protects the liver in a high-saccharide environment remains to be investigated. HepG2 cells were cultured with 30 mM D-ribose to mimic the high-oxidative-stress environment, typical of a liver in a diabetic patient. Three different chemical types of C. osmophloeum ethanol extracts (CEEs) were added in HepG2 culture media and the administration of all three CEEs protected HepG2 cells from D-ribose damage and increased cell survival by approximately 20 percent...
September 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29354299/ameliorative-effects-of-type-a-procyanidins-polyphenols-from-cinnamon-bark-in-compound-48-80-induced-mast-cell-degranulation
#10
Amit D Kandhare, Urmila M Aswar, Vishwaraman Mohan, Prasad A Thakurdesai
Allergic diseases are a significant health concern in developing countries. Type-A procyanidin polyphenols from cinnamon (Cinnamomum zeylanicum Blume) bark (TAPP-CZ) possesses antiasthmatic and antiallergic potential. The present study was aimed at the possible anti-allergic mechanism of TAPP-CZ against the compound 48/80 (C48/80)-induced mast cell degranulation in isolated rat peritoneal mast cells (RPMCs). TAPP-CZ (1, 3, 10, and 30 µg/ml) was incubated for 3 hours with isolated, purified RPMCs. The C48/80 (1 µg/ml) was used to induce mast cell degranulation...
December 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29338637/selected-plant-essential-oils-and-their-main-active-components-a-promising-approach-to-inhibit-aflatoxigenic-fungi-and-aflatoxin-production-in-food
#11
José Vicente Gómez, Andrea Tarazona, Rufino Mateo-Castro, José Vicente Gimeno-Adelantado, Misericordia Jiménez, Eva M Mateo
Recent research has showed that Aspergillus flavus and Aspergillus parasiticus are aflatoxigenic species that can become very competitive in the framework of climate change. Aflatoxins show carcinogenic, mutagenic, immunotoxic and teratogenic effects on human and animals. Effective and sustainable measures to inhibit these species and aflatoxins in food are required. Origanum vulgare and Cinnamomum zeylanicum essential oils (EOs) and their major active constituents, carvacrol and cinnamaldehyde, respectively, were assayed for inhibiting these species and aflatoxin production in maize extract medium under different environmental conditions...
January 17, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/29333095/cinnamomum-cassia-extracts-suppress-human-lung-cancer-cells-invasion-by-reducing-u-pa-mmp-expression-through-the-fak-to-erk-pathways
#12
Hsing-Chen Wu, Chi-Ting Horng, You-Li Lee, Pei-Ni Chen, Chin-Yin Lin, Chen-Yu Liao, Yih-Shou Hsieh, Shu-Chen Chu
Cinnamomum cassia exhibits antioxidative, apoptotic, and cytostatic properties. These activities have been attributed to the modulation of several biological processes and are beneficial for possible pharmaceutical applications. However, the potential of C. cassia in retarding lung adenocarcinoma cells metastasis remains ambiguous. We determined whether C. cassia extract (CCE) reduces metastasis of human lung adenocarcinoma cells. The results showed that CCE treatment (up to 60 μg/mL) for 24 h exhibited no cytotoxicity on the A549 and H1299 cell lines but inhibited the motility, invasiveness, and migration of these cells by repressing matrix metalloproteinase (MMP)-2 and urokinase-type plasminogen activator (u-PA)...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29329403/host-tree-selection-by-the-invasive-argentine-ant-hymenoptera-formicidae-in-relation-to-honeydew-producing-insects
#13
Yugo Seko, Daisuke Hayasaka, Atsushi Nishino, Taizo Uchida, Francisco Sánchez-Bayo, Takuo Sawahata
The Argentine ant, Linepithema humile (Mayr; Hymenoptera: Formicidae), is one of the world's most hazardous invasive species, and thus its eradication from Japan is important. Physical and chemical controls can be expensive and cause strong adverse effects on local terrestrial ecosystems regardless of their high efficacy. Here, presence/absence of host-tree selection by Argentine ants was investigated to understand the ant-honeydew-producing insects interactions in order to develop new cultural controls compatible with biodiversity conservation...
January 10, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29326134/evaluation-of-estrogenic-potential-by-herbal-formula-hpc-03-for-in-vitro-and-in-vivo
#14
Bo Yoon Chang, Dae Sung Kim, Hye Soo Kim, Sung Yeon Kim
HPC 03 is herbal formula that consists of extracts from Angelica gigas, Cnidium officinale Makino and Cinnamomum cassia Presl. The present study evaluated the estrogenic potential of HPC 03 by using in vitro and in vivo models. The regulatory mechanisms of HPC 03 in estrogen-dependent MCF-7 cells were assessed. HPC 03 induced the proliferation of estrogen receptor-positive MCF-7 cells, and the proliferation was blocked by the addition of the estrogen antagonist tamoxifen. The estrogen receptorα/β luciferase activities were significantly increased by HPC 03 treatment, which also increased the mRNA expression of the estrogen-responsive genes Psen2, Pgr and Ctsd Also, we evaluated the ameliorative effects of HPC 03 on menopausal symptoms in ovariectomized rats...
February 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29325862/antibacterial-effects-of-cinnamon-cinnamomum-zeylanicum-bark-essential-oil-on-porphyromonas-gingivalis
#15
Yue Wang, Yi Zhang, Yan-Qin Shi, Xian-Hua Pan, Yan-Hua Lu, Ping Cao
The objective of this study was to investigate the antibacterial effects of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) and its principal constituent cinnamaldehyde against Porphyromonas gingivalis and to elucidate the antibacterial mechanism. GC-MS analysis showed that cinnamaldehyde was the major constituent in CBEO (57.97%). The minimum inhibition concentrations (MICs) of CBEO and cinnamaldehyde were 6.25 μg/mL and 2.5 μM for P. gingivalis, respectively. Nucleic acid and protein leakage was observed with increasing concentrations of CBEO and cinnamaldehyde...
January 9, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29321988/hypolipidemic-effects-of-s-linalool-and-essential-oil-from-cinnamomum-osmophloeum-ct-linalool-leaves-in-mice
#16
Bing-Ho Cheng, Lee-Yan Sheen, Shang-Tzen Chang
Cinnamomum osmophloeum ( tǔ ròu guì) ct. linalool is one of the chemotypes of the indigenous cinnamon in Taiwan. S-(+)-linalool is the major constituent of leaf essential oil (LEO) of C. osmophloeum ct. linalool. This study aimed to investigate its physiological effects including body weight changes, blood biochemical values, and histopathological changes in mice. The mice were treated with LEO, S-(+)-linalool, and R-(-)-linalool. Results demonstrated similar physiological changes in mice treated with LEO and S-(+)-linalool, but significantly different effects in the body weight, TG, TC and blood glucose of R-(-)-linalool group...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29319361/cinnamon-cinnamomum-zeylanicum-as-an-antidote-or-a-protective-agent-against-natural-or-chemical-toxicities-a-review
#17
Mahyar Dorri, Shirin Hashemitabar, Hossein Hosseinzadeh
Cinnamon (Cinnamomum zeylanicum, Lauraceae) is a food additive greatly used for its taste. However, recently this medicinal plant has been brought to attention due to its medical effects. Cinnamon has constituents such as cinnamaldehyde and cinnamic acid that offers some health benefits including antioxidant and free-radical scavenging properties, lowering of blood glucose, anti-cholesterolemic, analgesic, antimicrobial, anti-inflammatory, anti-yeast, anti-secretagogue, and anti-gastric ulcer effects. This review summarizes various in vitro and animal studies on the protective effects of cinnamon against natural and chemical toxins...
January 10, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29282046/evaluation-of-pharmacodynamic-properties-and-safety-of-cinnamomum-zeylanicum-ceylon-cinnamon-in-healthy-adults-a-phase-i-clinical-trial
#18
Priyanga Ranasinghe, Ranil Jayawardena, Shehani Pigera, Wasundara Sevwandi Wathurapatha, Hasitha Dhananjaya Weeratunga, G A Sirimal Premakumara, Prasad Katulanda, Godwin Roger Constantine, Priyadarshani Galappaththy
BACKGROUND: Cinnamon is considered as a treatment for many ailments in native medicine. Evidence suggests that Cinnamomum zeylanicum (CZ) has anti-microbial, anti-parasitic, anti-oxidant, blood glucose lowering properties and beneficial cardiovascular effects. The present study aims to evaluate Pharmacodynamic properties and safety of CZ in healthy adults using a Phase I Clinical Trial. METHODS: This phase I clinical trial was conducted at the Department of Pharmacology, Faculty of Medicine, University of Colombo, Sri Lanka...
December 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29234401/trans-cinnamaldehyde-inhibits-microglial-activation-and-improves-neuronal-survival-against-neuroinflammation-in-bv2-microglial-cells-with-lipopolysaccharide-stimulation
#19
Yan Fu, Pin Yang, Yang Zhao, Liqing Zhang, Zhangang Zhang, Xianwen Dong, Zhongping Wu, Ying Xu, Yongjun Chen
Background: Microglial activation contributes to neuroinflammation and neuronal damage in neurodegenerative disorders including Alzheimer's and Parkinson's diseases. It has been suggested that neurodegenerative disorders may be improved if neuroinflammation can be controlled. trans-cinnamaldehyde (TCA) isolated from the stem bark of Cinnamomum cassia possesses potent anti-inflammatory capability; we thus tested whether TCA presents neuroprotective effects on improving neuronal survival by inhibiting neuroinflammatory responses in BV2 microglial cells...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29207708/in-vitro-anti-cariogenic-plaque-effects-of-essential-oils-extracted-from-culinary-herbs
#20
Kornsit Wiwattanarattanabut, Suwan Choonharuangdej, Theerathavaj Srithavaj
Introduction: Cariogenic bacteria including mutans streptococci and lactobacilli are partly but significantly involved in dental caries development. An effective prevention strategy against dental caries is to decrease the accumulation of this microbiota either in planktonic or in biofilm form. Aim: To examine the antimicrobial and anti-plaque effects of some culinary herbs (spices), so the herbs are plausibly used as alternative and effective herbal plaque control supplements to promote good oral health...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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