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https://www.readbyqxmd.com/read/28627583/deoxyactein-protects-pancreatic-%C3%AE-cells-against-methylglyoxal-induced-oxidative-cell-damage-by-the-upregulation-of-mitochondrial-biogenesis
#1
Kwang Sik Suh, Eun Mi Choi, Woon-Won Jung, Yu Jin Kim, Soo Min Hong, So Yong Park, Sang Youl Rhee, Suk Chon
Methylglyoxal (MG) is one of the major precursors of advanced glycation end products (AGEs), which are considered to be one of the causes of diabetes and its complications. The root and rhizomes of black cohosh (Cimicifuga racemosa) have long been used medicinally, and deoxyactein is one of its major constituents. In the present study, the protective effects of deoxyactein against MG-induced oxidative cell damage were investigated in insulin-producing pancreatic β-cells. We found that deoxyactein protected the pancreatic β-cells against MG-induced cell death...
June 12, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28590038/effects-of-estrogen-and-cimicifuga-racemosa-on-the-cardiac-norepinephrine-pathway-of-ovariectomized-rats
#2
Yao Liu, Jing Zhang, Shuya Liu, Wenjuan Wang, Xing Chen, Hai Jiang, Junlei Li, Ke Wang, Wenpei Bai, Haicheng Zhang, Lihua Qin
This study aimed to investigate the effects of estrogen and Cimicifuga racemosa on the stellate ganglion, cardiac norepinephrine pathway, and Ca(2+) /calmodulin-dependent protein kinase II (CaMK II). Forty adult female Sprague Dawley rats were randomly divided into four groups: SHAM, ovariectomized (OVX), ovariectomized with estrogen treatment (E2), and ovariectomized with Cimicifuga racemosa treatment (iCR). After 4 weeks of treatment, norepinephrine (NE) content was determined by high-performance liquid chromatography, and dopamine beta-hydroxylase (DBH) and norepinephrine transporter (NET) expression was detected by immunohistochemistry...
June 7, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28558206/inhibition-potential-of-cycloartane-type-glycosides-from-the-roots-of-cimicifuga-dahurica-against-soluble-epoxide-hydrolase
#3
Nguyen Phuong Thao, Bui Thi Thuy Luyen, Ji Sun Lee, Jang Hoon Kim, Nguyen Tien Dat, Young Ho Kim
A phytochemical assay-guided fractionation of the 95% ethanol extract of Cimicifuga dahurica roots afforded 29 9,19-cycloartane triterpenoid glycosides, including the new cimiricasides A-F (1-6). The structures of 1-6 were established using contemporary NMR methods and from the HRESIMS data, and the sugar moiety in each case was confirmed by acid hydrolysis and subsequent GC/MS analysis. Compounds 2, 4, 5, 7-9, 18, 25, and 29 showed soluble epoxide hydrolase inhibitory effects with IC50 values of 0.4 ± 0.1 to 24...
May 30, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28403500/nir-spectroscopy-of-actaea-racemosa-l-%C3%A2-rhizome-en-route-to-fast-and-low-cost-quality-assessment
#4
Marian Bittner, Andrea Krähmer, Regina Schenk, Andreas Springer, Gennadi Gudi, Matthias F Melzig
Rhizomes of Actaea racemosa L. (formerly Cimicifuga racemosa) gained increasing interest as a plant-derived drug due to its hormone-like activity and the absence of estrogenic activity. According to the Current Good Manufacturing Practices guidelines and pharmacopeial standards, quality assessment of herbal starting materials includes tests on identity and substitution, as well as quantification of secondary metabolites, usually by HPTLC and LC methods. To reduce the laboratory effort, we investigated near-infrared spectroscopy for rapid species authentication and quantification of metabolites of interest...
April 12, 2017: Planta Medica
https://www.readbyqxmd.com/read/28393490/cimicifoetones%C3%A2-a-and-b-dimeric-prenylindole-alkaloids-as-black-pigments-of-cimicifuga-foetida
#5
Chang-Xin Zhou, Yu-E Yu, Rong Sheng, Jian-Xia Mo, Min Huang, Liang Ouyang, Li-She Gan
Two dimeric prenylindole alkaloids with a unique indole-benzoindolequinone skeleton, cimicifoetones A (1) and B (2), were isolated as black pigments from the rhizomes of Cimicifuga foetida. The structures were elucidated by spectroscopic methods including HRMS and 2D NMR, as well as single-crystal X-ray diffraction and computational chemical modeling techniques. Cimicifoetones A and B represented the first examples of dimeric indole alkaloids generated through [4+2] Diels-Alder cycloaddition between the prenyl side chain in one 3-prenylindole and the aromatic ring in another...
April 9, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28352313/effects-of-cimicifugae-rhizoma-on-the-osteogenic-and-adipogenic-differentiation-of-stem-cells
#6
Ji-Eun Lee, Bo-Bae Kim, Youngkyung Ko, Su-Hyeon Jeong, Jun-Beom Park
Cimicifugae Rhizoma, a herb with a long history of use in traditional Oriental medicine is reported to have anti-inflammatory, antioxidant, anti-complement and anticancer effects. The aim of the present study was to evaluate the effects of Cimicifugae Rhizoma extracts on the osteogenic and adipogenic differentiation of human stem cells derived from gingiva. Stem cells derived from gingiva were grown in the presence of Cimicifugae Rhizoma at final concentrations of 0.1, 1 and 10 µg/ml. Cell proliferation analyses were performed at day 15...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28347916/cimicifugamide-from-cimicifuga-rhizomes-functions-as-a-nonselective-%C3%AE-ar-agonist-for-cardiac-and-sudorific-effects
#7
ZengYong Wang, Qian Wang, Man Zhang, XueYan Hu, GuoYu Ding, Min Jiang, Gang Bai
Cimicifuga rhizomes (CR) are used in the treatment of respiratory and cardiovascular diseases in traditional Chinese medicine, but their key effective components and mechanism of action have not yet been reported. In this study, the cardiac, antipyretic and sudorific effects of CR were evaluated using the toad heart failure in vitro model and mice fever and sweating in vivo models. Moreover, the UPLC/Q-TOF-MS-integrated β2-AR luciferase reporter gene assay system was used to screen the bioactive ingredients from CR extract, and the activity of this ingredient were verified using the above-mentioned in vitro and vivo models...
June 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28303225/identification-and-differentiation-of-major-components-in-three-different-sheng-ma-crude-drug-species-by-uplc-q-tof-ms
#8
Mengxue Fan, Kunming Qin, Fei Ding, Yuting Huang, Xiaoli Wang, Baochang Cai
Cimicifugae Rhizoma (Sheng ma) is a Ranunculaceae herb belonging to a composite family and well known in China. has been widely used in traditional Chinese medicine. The Pharmacopoeia of the People׳s Republic of China contains three varieties (Cimicifuga dahurica (Turcz.), Cimicifuga foetida L. and Cimicifuga heracleifolia Kom.) which have been used clinically as "Sheng-ma". However, the chemical constituents of three components of "Sheng-ma" have never been documented. In this study, a rapid method for the analysis of the main components of "Sheng-ma" was developed using ultra-high performance liquid chromatography with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF-MS)...
March 2017: Acta Pharmaceutica Sinica. B
https://www.readbyqxmd.com/read/28288692/does-cimicifuga-racemosa-have-the-effects-like-estrogen-on-the-sublingual-gland-in-ovariectomized-rats
#9
Yun-Meng Da, Kai-Yu Niu, Shu-Ya Liu, Ke Wang, Wen-Juan Wang, Jing Jia, Li-Hua Qin, Wen-Pei Bai
BACKGROUND: Cimicifuga racemosa is one of the herbs used for the treatment of climacteric syndrome, and it has been cited as an alternative therapy to estrogen. Apart from hectic fevers, dyspareunia and so on, dry mouth also increase significantly after menopause. It has not yet been reported whether C. racemosa has any impact on the sublingual gland, which may relate to dry mouth. In an attempt to determine this, we have compared the effects of estrogen and C. racemosa on the sublingual gland of ovariectomized rats...
March 14, 2017: Biological Research
https://www.readbyqxmd.com/read/28279529/soluble-epoxide-hydrolase-inhibitors-of-indolinone-alkaloids-and-phenolic-derivatives-from-cimicifuga-dahurica-turcz-maxim
#10
Nguyen Phuong Thao, Bui Thi Thuy Luyen, Ji Sun Lee, Jang Hoon Kim, Young Ho Kim
The aim of this study was to search for potential therapeutic agents by identifying novel inhibitors of soluble epoxide hydrolase (sEH) from natural plants using an in silico approach. We found that an ethanolic extract from the roots of Cimicifuga dahurica (Turcz.) Maxim. significantly inhibited sEH in vitro. In a phytochemical investigation using assay-guided fractionation of the dichloromethane extract of C. dahurica, we isolated two new indolinone alkaloids (5 and 6) and five related constituents (1-4, and 7) and established their structures based on an extensive analysis using 1D and 2D NMR, and MS methods...
February 9, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28260002/a-novel-cycloartane-triterpenoid-from-cimicifuga-induces-apoptotic-and-autophagic-cell-death-in-human-colon-cancer-ht-29-cells
#11
Xiaoli Dai, Jing Liu, Yin Nian, Ming-Hua Qiu, Ying Luo, Jihong Zhang
The extract from Cimicifuga, a genus of flowering plants, has been demonstrated to have mainly therapeutic effects on menstrual and menopausal symptoms and also exhibits immunomodulatory, anti-inflammatory and antimicrobial activity. Moreover, the anticancer effects of Cimicifuga have been reported, but the underlying mechanism causing cancer cell death has been poorly described. The present study was designed to investigate the antitumor effects and underlying molecular mechanisms of cimigenol (KY17), a novel cycloartane triterpenoid from Cimicifuga...
April 2017: Oncology Reports
https://www.readbyqxmd.com/read/28236402/photochemistry-and-pharmacology-of-9-19-cyclolanostane-glycosides-isolated-from-genus-cimicifuga
#12
REVIEW
Yang Su, Wen-Cheng Chi, Lun Wu, Qiu-Hong Wang, Hai-Xue Kuang
The constituents of Cimicifuga plants have been extensively investigated, and the principal metabolites are 9, 19-cyclolanostane triterpenoid glycosides, which often exhibit extensive pharmacological activities. 9, 19-Cyclolanostane triterpenoid glycosides are distributed widely in genus Cimicifuga rather than in other members of the Ranunculaceae family. So far, more than 140 cycloartane triterpene glycosides have been isolated from Cimicifuga spp.. The aim of this review was to summarize all 9, 19-cyclolanostane triterpenoid glycosides based on the available relevant scientific literatures from 2000 to 2014...
October 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28188798/in-silico-investigation-of-cycloartane-triterpene-derivatives-from-cimicifuga-dahurica-turcz-maxim-roots-for-the-development-of-potent-soluble-epoxide-hydrolase-inhibitors
#13
Nguyen Phuong Thao, Jang Hoon Kim, Bui Thi Thuy Luyen, Nguyen Tien Dat, Young Ho Kim
In our search for natural soluble epoxide hydrolase (sEH) inhibitors from plants, we found that an ethanolic extract of the roots of Cimicifuga dahurica (Turcz.) Maxim. significantly inhibits sEH in vitro. A phytochemical study on the dichloromethane fraction of C. dahurica resulted in the isolation of two new cycloartane triterpenoids (1 and 6), together with 13 known cycloartane analogues (2-5 and 7-15). The structures of compounds were determined by spectroscopic methods. All of the triterpenoid derivatives inhibited sEH enzymatic activity in a concentration-dependent manner, and 13 of the tested compounds showed significant activity...
May 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28155126/60%C3%A2-years-of-cimicifuga-racemosa-medicinal-products-clinical-research-milestones-current-study-findings-and-current-development
#14
Hans-Heinrich Henneicke-von Zepelin
Cimicifuga racemosa (CR) extracts are important worldwide as therapy for menopausal symptoms. The first medicinal product from CR has been available since 1956 (Germany, Remifemin® [Schaper & Brümmer, Salzgitter, Germany], isopropanolic extract iCR). This review describes how CR developed, via clinical studies on safety (breast, breast cancer, endometrium, liver) and efficacy, into a successful and safe medicinal product in Germany, Europe and the world. In line with developing legal frameworks for medicinal products in Germany and Europe, clinical studies on CR were observational during the 50s and 70s, and controlled studies since the 80s...
May 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28110190/actein-ameliorates-hepatobiliary-cancer-through-stemness-and-p53-signaling-regulation
#15
Rui Xi, Li-Juan Wang
Actein is isolated from the rthizomes of Cimicifuga foetida, which is a triterpene glycoside, displaying suppressive effects on breast cancer cells proliferation. However, the effects of actein treatment on liver injury, tending to cancer, have little to be known. Thus, the study is conducted to explore the role of actein in early liver cancer. Diethylnitrosamine (DEN) was used to induce liver cancer in mice followed by actein treatment at different concentrations. DEN caused steatohepatitis supported by fibrosis and inflammation, which were ameliorated for actein administration...
April 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27976223/a-new-lc-ms-assay-for-determination-of-triterpene-glycosides-in-cimicifuga-racemosa-avoiding-overestimation-problems-during-stability-testing
#16
A Schenk, B Siewert, S Toff, J Drewe
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27914809/actein-enhances-trail-effects-on-suppressing-gastric-cancer-progression-by-activating-p53-caspase-3-signaling
#17
Zhi-Chao Yang, Ji Ma
Actein (ACT), isolated from the rthizomes of Cimicifuga foetida, is a triterpene glycoside, showing inhibitory role in breast cancer cells. However, the effects of ACT treatment on gastric cancer have little been known. Thus, the study is conducted to explore the in vitro and in vivo role of ACT in gastric cancer. And the interactions between ACT and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) were investigated in gastric cancer cells. A synergistic effect of ACT and TRAIL combination on apoptosis induction in gastric cancer cells was observed...
November 30, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27731376/new-potential-beneficial-effects-of-actein-a-triterpene-glycoside-isolated-from-cimicifuga-species-in-breast-cancer-treatment
#18
Grace Gar-Lee Yue, Sida Xie, Julia Kin-Ming Lee, Hin-Fai Kwok, Si Gao, Yin Nian, Xiao-Xiao Wu, Chun-Kwok Wong, Ming-Hua Qiu, Clara Bik-San Lau
Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida (Chinese herb "shengma") which could inhibit the growth of breast cancer cells. Nevertheless, the effect of actein on angiogenesis, which is an essential step for tumor growth and metastasis, has never been reported. Hence, this study aimed to investigate the in vitro and in vivo effects of actein on angiogenesis using human microvascular endothelial cells (HMEC-1), matrigel plug and tumor-bearing mouse models. Our results showed that actein significantly inhibited the proliferation, reduced the migration and motility of endothelial cells, and it could suppress the protein expressions of VEGFR1, pJNK and pERK, suggesting that JNK/ERK pathways were involved...
October 12, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27693743/polyphenolic-compounds-with-antioxidant-potential-and-neuro-protective-effect-from-cimicifuga-dahurica-turcz-maxim
#19
Rulan Qin, Ying Zhao, Yudan Zhao, Wanrong Zhou, Chongning Lv, Jincai Lu
Three new phenolic compounds (1-3), along with five known compounds (4-8) were isolated from the rhizome of Cimicifuga dahurica (Turcz.) Maxim. Their structures were elucidated by spectroscopic methods including 1D-NMR, 2D-NMR and HR-MS techniques. DPPH method and protective effect on PC12 cells against H2O2-induced oxidative damage model were carried to evaluate the antioxidant capability of these compounds. Compound 5 showed significant antioxidant activity with IC50 values 9.33μM in DPPH assay and compound 2 displayed marked neuro-protective effect with 87...
December 2016: Fitoterapia
https://www.readbyqxmd.com/read/27690371/economical-plain-and-rapid-authentication-of-actaea-racemosa-l-syn-cimicifuga-racemosa-black-cohosh-herbal-raw-material-by-resilient-rp-pda-hplc-and-chemometric-analysis
#20
Marian Bittner, Regina Schenk, Andreas Springer, Matthias F Melzig
INTRODUCTION: The medicinal plant Actaea racemosa L. (Ranunculaceae, aka black cohosh) is widely used to treat climacteric complaints as an alternative to hormone substitution. Recent trials prove efficacy and safety of the approved herbal medicinal products from extracts of pharmaceutical quality. This led to worldwide increasing sales. A higher demand for the plant material results in problems with economically motivated adulteration. Thus, reliable tools for herbal drug authentication are necessary...
November 2016: Phytochemical Analysis: PCA
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