Le-Jun Huang, Jin-Xia Lan, Jin-Hua Wang, Hao Huang, Kuo Lu, Zhi-Nuo Zhou, Su-Ya Xin, Zi-Yun Zhang, Jing-Yang Wang, Ping Dai, Xiao-Mei Chen, Wen Hou
Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to possess broad-spectrum biological activities, such as antitumor, anti-inflammatory, antiosteoporosis, neuroprotective, and antipathogenic microorganism activities. In this paper, recent progress on the biological activity and mechanism of action of sanguinarine and its derivatives over the past ten years is reviewed. The results showed that the biological activities of hematarginine and its derivatives are related mainly to the JAK/STAT, PI3K/Akt/mTOR, NF-κB, TGF-β, MAPK and Wnt/β-catenin signaling pathways...
March 8, 2024: Biomedicine & Pharmacotherapy