keyword
MENU ▼
Read by QxMD icon Read
search

chelidonium

keyword
https://www.readbyqxmd.com/read/29107235/larvicidal-activity-and-insecticidal-mechanism-of-chelidonium-majus-on-lymantria-dispar
#1
ChuanShan Zou, ChunHe Lv, YaJun Wang, ChuanWang Cao, GuoCai Zhang
Based on the broad spectrum of its biological activities, Chelidonium majus has been studied extensively in the medical field. However, few studies have focused on the insecticidal activity of C. majus, and the precise mechanism of its insecticidal activity. In the present study, larvicidal activity and insecticidal mechanism of C. majus on Lymantria dispar were investigated using bioassays, in vitro and in vivo enzyme activity assays, determination of the nutritional index, and gene transcription analysis...
October 2017: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29102247/enrichment-of-chelidonine-from-chelidonium-majus-l-using-macroporous-resin-and-its-antifungal-activity
#2
Jialiang Pan, Yang Yang, Rui Zhang, Hanwen Yao, Kangkang Ge, Manyin Zhang, Ling Ma
Chelidonium majus L. (greater celandine) has been used as an herbal medicine for several centuries. This study investigated an efficient method to purify chelidonine from the extract of C. majus L. using macroporous adsorption resins and evaluated the antifungal activity of chelidonine against Botryosphaeria dothidea as a model strain. Static adsorption and desorption tests revealed that D101 was the optimal resin for chelidonine purification. Pseudo-second-order kinetics model and Freundlich equation model were the most suitable for evaluating the endothermic and spontaneous adsorption processes of chelidonine on D101...
October 20, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29044876/chelidonine-inhibits-tnf-%C3%AE-induced-inflammation-by-suppressing-the-nf-%C3%AE%C2%BAb-pathways-in-hct116-cells
#3
Zhi Hong Zhang, Chunliu Mi, Ke Si Wang, Zhe Wang, Ming Yue Li, Hong Xiang Zuo, Guang Hua Xu, Xuezheng Li, Lian Xun Piao, Juan Ma, Xuejun Jin
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a complex that regulates several hundreds of genes, including those involved in immunity and inflammation, survival, proliferation, and the negative feedback of NF-κB signaling. Chelidonine, a major bioactive, isoquinoline alkaloid ingredient in Chelidonium majus, exhibits antiinflammatory pharmacological properties. However, its antiinflammatory molecular mechanisms remain unclear. In this work, we explored the effect of chelidonine on TNF-induced NF-κB activation in HCT116 cells...
October 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28951771/uplc-ms-ms-profile-of-alkaloids-with-cytotoxic-properties-of-selected-medicinal-plants-of-the-berberidaceae-and-papaveraceae-families
#4
Anna Och, Katarzyna Szewczyk, Łukasz Pecio, Anna Stochmal, Daniel Załuski, Anna Bogucka-Kocka
Cancer is one of the most occurring diseases in developed and developing countries. Plant-based compounds are still researched for their anticancer activity and for their quantity in plants. Therefore, the modern chromatographic methods are applied to quantify them in plants, for example, UPLC-MS/MS (ultraperformance liquid chromatography tandem mass spectrometry). Therefore, the aim of the present study was to evaluate the content of sanguinarine, berberine, protopine, and chelidonine in Dicentra spectabilis (L...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28938145/six-scalemic-mixtures-of-6-monosubstituted-dihydrobenzophenanthridine-alkaloids-from-chelidonium-majus-and-optically-active-structures-of-enantiomers
#5
An-Jun Deng, Hai-Jing Zhang, Qian Li, Zhi-Hong Li, Zhi-Hui Zhang, Lian-Qiu Wu, Li Li, Hai-Lin Qin
Six pairs of previously undescribed 6-monosubstituted dihydrobenzophenanthridine alkaloids were separated as corresponding six scalemic mixtures from the aerial part of Chelidonium majus. The elucidation for the 2D structures of these alkaloids was achieved using regular spectroscopic and chemical methods. The assignment of scalemic-mixture nature was achieved using combined examinations of their NMR data, CD spectra, calculation of specific rotations, and chiral HPLC profiles. The identification for the relative configurations of alkaloids possessing two asymmetric carbons directly connected up by a rotatable sp(3)-sp(3) carbon-carbon single bond was significantly facilitated by discussing the erythro and threo relative configurations defined by the mutuality of the orders of decreasing steric hindrances between the two sets of ligands linked to the two chiral centers...
September 19, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28725082/retention-and-separation-changes-of-ternary-and-quaternary-alkaloids-from-chelidonium-majus-l-by-tlc-under-the-influence-of-external-magnetic-field
#6
Irena Malinowska, Marek Studziński, Henryk Malinowski, Maria Gadzikowska
Thin layer techniques proved their usefulness in the analysis of plant extract material. Thanks to their low operation costs, high sample throughput and possibility to gather chromatographic data for the whole sample in a single act, they allowed to find, and in some cases identify, active ingredients often hidden in sophisticated plant extract matrices. It was also proved that the presence of a magnetic field changes the retention of some substances, and moreover changes the separation efficiency of chromatographic systems...
2017: Chromatographia
https://www.readbyqxmd.com/read/28633475/cloning-and-characterization-of-cheilanthifoline-and-stylopine-synthase-genes-from-chelidonium-majus
#7
Mahdi Yahyazadeh, Purwanto Ratmoyo, Florian Bittner, Fumihiko Sato, Dirk Selmar
The most prominent alkaloid of Chelidonium majus is dihydrocoptisine, revealing the characteristic benzophenanthridine skeleton. To date, any informationon on the enzymes responsible for its biosynthesis and the related genes in C. majus is lacking. Based on sequence similarities to the corresponding methylenedioxy bridge-forming Cyt P450 enzymes involved in isoquinoline alkaloid biosynthesis in Eschscholzia californica, genes for a cheilanthifoline synthase and a stylopine synthase from C. majus were isolated, sequenced and heterologously expressed in yeast...
August 1, 2017: Plant & Cell Physiology
https://www.readbyqxmd.com/read/28619636/isolation-and-characterization-of-a-non-specific-lipid-transfer-protein-from-chelidonium-majus-l-latex
#8
Robert Nawrot, Damian Józefiak, Anna Sip, Dorota Kuźma, Oskar Musidlak, Anna Goździcka-Józefiak
Plant non-specific lipid transfer proteins (nsLTPs) are small basic proteins, which mostly play a role in intracellular lipid transport and antimicrobial defense. Recently it was shown using shotgun proteomic approach that the whole plant extract of Chelidonium majus L. (Papaveraceae) contains relatively abundant nsLTPs. Therefore the aim of the work was to isolate and characterize nsLTP from C. majus latex. Results obtained using PCR approach with degenerate primers showed the presence of nsLTP protein in C...
November 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28501427/ethnopharmacological-approach-to-the-herbal-medicines-of-the-elements-alpha-to-delta-in-nikolaos-myrepsos-dynameron-part-ii
#9
E Valiakos, M Marselos, N Sakellaridis, Th Constantinidis, H Skaltsa
ETHNOPHARMACOLOGICAL RELEVANCE: Dynameron is a Byzantine medical compendium, divided into 24 sections, the "Elements", containing 2667 recipes, most of which inherited by previous physicians of the classic ancient Greek and Hellenistic, and imperial Roman periods. AIM OF THE STUDY: In continuation to our previous study concerning the first and largest chapter of the "Element Alpha" of Nikolaos Myrepsos׳ Dynameron (Valiakos et al., 2015), this paper focuses on the plants quoted in the recipes of the eight following chapters entitled "About Salts", "About Honeypacks" and "About Spreads", all belonging to the same "Element Alpha"; "About Antitussives" and "About Suppositories" belonging to the "Element Beta"; "About women's Cathartics" belonging to the "Element Gamma"; "About Drossaton" and "About Diachrisma", both belonging to the "Element Delta"...
May 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28479277/selectivity-of-major-isoquinoline-alkaloids-from-chelidonium-majus-towards-telomeric-g-quadruplex-a-study-using-a-transition-fret-t-fret-assay
#10
Sakineh Kazemi Noureini, Hosein Esmaeili, Farzane Abachi, Soraia Khiali, Barira Islam, Martyna Kuta, Ali A Saboury, Marcin Hoffmann, Jiri Sponer, Gary Parkinson, Shozeb Haider
BACKGROUND: Natural bioproducts are invaluable resources in drug discovery. Isoquinoline alkaloids of Chelidonium majus constitute a structurally diverse family of natural products that are of great interest, one of them being their selectivity for human telomeric G-quadruplex structure and telomerase inhibition. METHODS: The study focuses on the mechanism of telomerase inhibition by stabilization of telomeric G-quadruplex structures by berberine, chelerythrine, chelidonine, sanguinarine and papaverine...
August 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28394023/crowdcurio-an-online-crowdsourcing-platform-to-facilitate-climate-change-studies-using-herbarium-specimens
#11
Charles G Willis, Edith Law, Alex C Williams, Brian F Franzone, Rebecca Bernardos, Lian Bruno, Claire Hopkins, Christian Schorn, Ella Weber, Daniel S Park, Charles C Davis
Phenology is a key aspect of plant success. Recent research has demonstrated that herbarium specimens can provide important information on plant phenology. Massive digitization efforts have the potential to greatly expand herbarium-based phenological research, but also pose a serious challenge regarding efficient data collection. Here, we introduce CrowdCurio, a crowdsourcing tool for the collection of phenological data from herbarium specimens. We test its utility by having workers collect phenological data (number of flower buds, open flowers and fruits) from specimens of two common New England (USA) species: Chelidonium majus and Vaccinium angustifolium...
April 10, 2017: New Phytologist
https://www.readbyqxmd.com/read/28393701/defense-related-proteins-from-chelidonium-majus-l-as-important-components-of-its-latex
#12
REVIEW
Robert Nawrot
The aim of this review is to cover most recent research on plant pathogenesis- and defenserelated proteins from latex-bearing medicinal plant Chelidonium majus (Papaveraceae) in the context of its importance for latex activity, function, pharmacological activities, and antiviral medicinal use. These results are compared with other latex-bearing plant species and recent research on proteins and chemical compounds contained in their latex. This is the first review, which clearly summarizes pathogenesisrelated (PR) protein families in latex-bearing plants pointing into their possible functions...
2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/28379595/hepatotoxicity-induced-by-greater-celandine-chelidonium-majus-l-a-review-of-the-literature
#13
REVIEW
F Pantano, G Mannocchi, E Marinelli, S Gentili, S Graziano, F P Busardò, N M di Luca
The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper. Identification of significant scientific literature was performed via the following research databases: Cochrane Central, Google Scholar, EMBASE, Medline, Science Direct, Scopus, Web of Science, using the following keywords: "Chelidonium majus", "greater celandine", "Hepatotoxicity", "Liver" "Injury", "Toxicity" individually investigated and then again in association...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28131060/proteomic-comparison-of-chelidonium-majus-l-latex-in-different-phases-of-plant-development
#14
COMPARATIVE STUDY
Robert Nawrot, Rico Lippmann, Andrea Matros, Oskar Musidlak, Grzegorz Nowicki, Hans-Peter Mock
Chelidonium majus L. (Papaveraceae) latex is used in traditinonal folk medicine to treat papillae, warts, condylomas, which are visible effects of human papilloma virus (HPV) infections. The aim of this work was to provide new insights into the biology and medicinal use of C. majus milky sap in the flowering and fruit ripening period of the plant by comparing the protein content between samples collected on respective developmental stages using LC-MS-based label-free proteome approach. For quantification, the multiplexed LC-MS data were processed using comparative chemometric approach...
March 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27401454/combination-of-transcriptomic-and-proteomic-approaches-helps-to-unravel-the-protein-composition-of-chelidonium-majus-l-milky-sap
#15
Robert Nawrot, Jakub Barylski, Rico Lippmann, Lothar Altschmied, Hans-Peter Mock
A novel annotated Chelidonium majus L. transcriptome database composed of 23,004 unique coding sequences allowed to significantly improve the sensitivity of proteomic C. majus assessments, which showed novel defense-related proteins characteristic to its latex. To date, the composition of Chelidonium majus L. milky sap and biosynthesis of its components are poorly characterized. We, therefore, performed de novo sequencing and assembly of C. majus transcriptome using Illumina technology. Approximately, 119 Mb of raw sequence data was obtained...
November 2016: Planta
https://www.readbyqxmd.com/read/27350008/chelidonium-majus-crude-extract-inhibits-migration-and-induces-cell-cycle-arrest-and-apoptosis-in-tumor-cell-lines
#16
Milena Deljanin, Mladen Nikolic, Dejan Baskic, Danijela Todorovic, Predrag Djurdjevic, Milan Zaric, Milan Stankovic, Milos Todorovic, Dusko Avramovic, Suzana Popovic
ETHNOPHARMACOLOGICAL RELEVANCE: Chelidonium majus L (Papaveraceae) is widely used in alternative medicine for treatment of various disorders. Antitumor activities of alkaloids isolated from this plant have been reviewed, while there are only a few studies that examine properties of the whole extract. AIM OF THE STUDY: The aim of the present study was to investigate direct cytotoxic effects, as well as indirect antitumor effects of Chelidonium majus ethanolic extract against different tumor cell lines,...
August 22, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/26969379/comparative-cytotoxicity-of-chelidonine-and-homochelidonine-the-dimethoxy-analogues-isolated-from-chelidonium-majus-l-papaveraceae-against-human-leukemic-and-lung-carcinoma-cells
#17
Radim Havelek, Martina Seifrtova, Karel Kralovec, Eliska Krocova, Veronika Tejkalova, Ivan Novotny, Lucie Cahlikova, Marcela Safratova, Lubomir Opletal, Zuzana Bilkova, Jirina Vavrova, Martina Rezacova
BACKGROUND: The search for new anticancer compounds is a crucial element of natural products research. PURPOSE: In this study the effects of naturally occurring homochelidonine in comparison to chelidonine on cell cycle progression and cell death in leukemic T-cells with different p53 status are described. METHODS: The mechanism of cytotoxic, antiproliferative, apoptosis-inducing effects and the effect on expressions of cell cycle regulatory proteins was investigated using XTT assay, Trypan blue exclusion assay, flow cytometry, Western blot analysis, xCELLigence, epi-fluorescence and 3D super resolution microscopy...
March 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/26862303/evaluation-of-anti-inflammatory-and-analgesic-activities-of-extracts-from-herb-of-chelidonium-majus-l
#18
Przemysław Łukasz Mikołajczak, Bogdan Kędzia, Marcin Ożarowski, Radosław Kujawski, Anna Bogacz, Joanna Bartkowiak-Wieczorek, Wojciech Białas, Agnieszka Gryszczyńska, Waldemar Buchwald, Michał Szulc, Natalia Wasiak, Małgorzata Górska-Paukszta, Justyna Baraniak, Bogusław Czerny, Agnieszka Seremak-Mrozikiewicz
The aim of the study was to evaluate analgesic activity ("hot plate" test), anti-inflammatory activity (carrageenan-induced paw edema) and locomotor activity in rats under the influence of three fractions of Chelidonium majus herb extract: full water extract (FWE), protein enriched fraction (PEF), and non-protein fraction (NPF). Effects of the fractions on the level of chosen cytokines and their mRNA levels were also assessed using lipopolysaccharide (LPS) administration as a proinflammatory cue. All fractions and diclofenac did not affect the locomotor activity of rats in comparison with the control group...
2015: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/26773189/ukrain-nsc-631570-ameliorates-intestinal-ischemia-reperfusion-induced-acute-lung-injury-by-reducing-oxidative-stress
#19
Cengiz Kocak, Fatma Emel Kocak, Raziye Akcilar, Aydin Akcilar, Bircan Savran, Sezgin Zeren, Zulfu Bayhan, Zeynep Bayat
Intestinal ischemia-reperfusion (I/R) causes severe destruction in remote organs. Lung damage is a frequently seen complication after intestinal I/R. Ukrain (NSC 631570) is a synthetic thiophosphate derivative of alkaloids from the extract of the celandine (Chelidonium majus L.) plant. We investigated the effect of Ukrain in animals with lung injury induced by intestinal I/R. Adult male Spraque-Dawley rats were randomly divided into four groups: control, Ukrain, I/R, I/R with Ukrain. Before intestinal I/R was induced, Ukrain was administered intraperitoneally at a dose of 7...
January 15, 2016: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/26718183/investigation-of-the-composition-and-antibacterial-activity-of-ukrain%C3%A2-drug-using-liquid-chromatography-techniques
#20
Wioleta Jesionek, Emilia Fornal, Barbara Majer-Dziedzic, Ágnes M Móricz, Wassil Nowicky, Irena M Choma
The greater celandine (Chelidonium majus L.) has been known for the centuries as a medicinal plant. One of the therapeutic agents based on C. majus is anticancer drug Ukrain™ known as a semi-synthetic C. majus alkaloid derivative. Although there are no doubts about antitumor properties of the drug, there is still controversy about its composition. In this study, Ukrain™ was subjected to TLC and LC-MS/MS analyses to compare it with C. majus alkaloid root extract and to determine its composition. Moreover, microbiological activity of both Ukrain™ and the alkaloid extract were tested against Bacillus subtilis strains using TLC-direct bioautography...
January 15, 2016: Journal of Chromatography. A
keyword
keyword
95329
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"