keyword
https://read.qxmd.com/read/38095842/o-and-n-methyltransferases-in-benzylisoquinoline-alkaloid-producing-plants
#1
JOURNAL ARTICLE
Seungki Lee, Nam-Il Park, Yeri Park, Kyong-Cheul Park, Eun Sil Kim, Youn Kyoung Son, Beom-Soon Choi, Nam-Soo Kim, Ik-Young Choi
BACKGROUND: Secondary metabolites such as benzylisoquinoline alkaloids (BIA) have attracted considerable attention because of their pharmacological properties and potential therapeutic applications. Methyltransferases (MTs) can add methyl groups to alkaloid molecules, altering their physicochemical properties and bioactivity, stability, solubility, and recognition by other cellular components. Five types of O-methyltransferases and two types of N-methyltransferases are involved in BIA biosynthesis...
December 14, 2023: Genes & Genomics
https://read.qxmd.com/read/37910202/non-targeted-chemical-analysis-of-consumer-botanical-products-labeled-as-blue-cohosh-caulophyllum-thalictroides-goldenseal-hydrastis-canadensis-or-yohimbe-bark-pausinystalia-yohimbe-by-nmr-and-ms
#2
JOURNAL ARTICLE
Giovanni O Quiroz-Delfi, Cynthia V Rider, Stephen S Ferguson, Alan K Jarmusch, Geoffrey A Mueller
Consumers have unprecedented access to botanical dietary supplements through online retailers, making it difficult to ensure product quality and authenticity. Therefore, methods to survey and compare chemical compositions across botanical products are needed. Nuclear magnetic resonance (NMR) spectroscopy and non-targeted mass spectrometry (MS) were used to chemically analyze commercial products labeled as containing one of three botanicals: blue cohosh, goldenseal, and yohimbe bark. Aqueous and organic phase extracts were prepared and analyzed in tandem with NMR followed by MS...
November 1, 2023: Analytical and Bioanalytical Chemistry
https://read.qxmd.com/read/37652040/randomised-controlled-trial-on-prophylaxis-of-mastitis-metritis-agalactia-syndrome-in-swine-using-caulophyllum-logoplex-and-lachesis-logoplex
#3
JOURNAL ARTICLE
Kathrin Büttner, Janna Oelkers, Onno Burfeind, Joachim Krieter, Irena Czycholl
BACKGROUND:  Mastitis-metritis-agalactia (MMA) syndrome occurs in the first days post-partum and causes piglet losses mainly due to malnutrition. One possibility for prophylaxis of MMA is via homeopathy. In this veterinary study, the effectiveness of a prophylactic administration of homeopathic remedies for the prevention of the occurrence of MMA in swine was evaluated. METHODS:  In a randomised and blinded study, 60 sows were examined. Sows were randomly distributed in two groups: the experimental group (CL/LL) received a prophylactic administration of the complex homeopathic remedies Caulophyllum Logoplex and Lachesis Logoplex , and the placebo group was administered a sodium chloride (NaCl) solution in the same injection scheme as the experimental group...
August 31, 2023: Homeopathy: the Journal of the Faculty of Homeopathy
https://read.qxmd.com/read/37050109/isolation-and-characterization-of-the-genes-involved-in-the-berberine-synthesis-pathway-in-asian-blue-cohosh-caulophyllum-robustum
#4
JOURNAL ARTICLE
Nam-Il Park, Neha Samir Roy, Yeri Park, Beom-Soon Choi, Mi Jin Jeon, Ji Yeon Oh, Bo-Yun Kim, Young-Dong Kim, Yong-In Kim, Taeyoung Um, Hwan Jong Kwak, Nam-Soo Kim, Soonok Kim, Ik-Young Choi
Caulophyllum robustum , commonly named Asian blue cohosh, is a perennial herb in the family Berberidaceae. It has traditionally been used for folk medicine in China. We isolated berberine from the leaves, stem, roots, and fruits of C. robustum , and this is the first report on berberine in this species. Transcriptome analysis was conducted for the characterization of berberine biosynthesis genes in C. robustum , in which, all the genes for berberine biosynthesis were identified. From 40,094 transcripts, using gene ontology (GO) analysis, 26,750 transcripts were assigned their functions in the categories of biological process, molecular function, and cellular component...
March 28, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/35873997/plastid-phylogenomics-and-plastome-evolution-of-nandinoideae-berberidaceae
#5
JOURNAL ARTICLE
Shiqiang Song, Dmitriy Zubov, Hans Peter Comes, Haiwen Li, Xuelian Liu, Xin Zhong, Joongku Lee, Zhaoping Yang, Pan Li
Subfamily Nandinoideae Heintze (Berberidaceae), comprising four genera and ca. 19 species, is disjunctively distributed in eastern North America vs. Eurasia (eastern Asia, Central Asia, Middle East, and southeastern Europe), and represents an ideal taxon to explore plastid phylogenomics and plastome evolution in Berberidaceae. Many species of this subfamily have been listed as national or international rare and endangered plants. In this study, we sequenced and assembled 20 complete plastomes, representing three genera and 13 species of Nandinoideae...
2022: Frontiers in Plant Science
https://read.qxmd.com/read/35616229/two-new-sesquiterpenoids-from-plant-endophytic-fungus-flammulina-velutipes
#6
JOURNAL ARTICLE
Jia-Yao Hu, Ting Yang, Jie Liu, Lei Xiao, Li-Bin Lin, Yi-Chao Li, Ming-Yue Ge, Ping Ji, Jian Xiao, Xiao-Ling Wang
Two new sesquiterpenoids, flammupin A ( 1 ) and flammupin B ( 2 ), along with two known compounds, enokipodin C ( 3 ) and 5,5'-dibuthoxy-2,2'-bifuran ( 4 ) were obtained from Flammulina velutipes , an endophytic fungus isolated from the roots of Caulophyllum robustum Maxim. The structures were elucidated by the combination of HR-ESI-MS, NMR, and ECD analyses. Compound 3 exhibited moderate to potent cytotoxicity against A549, HeLa, and SMMC-7721 cells with IC50 values ranged from 3.69 to 11.84 μM.
May 26, 2022: Journal of Asian Natural Products Research
https://read.qxmd.com/read/35370205/caulophyine-a-a-rare-azapyrene-alkaloid-from-the-roots-of-caulophyllum-robustum
#7
JOURNAL ARTICLE
Wei Wei, Ya-Hong Yuan, Fu-Rong Jiao, Xiang Zhao, Lei Xiao, Jia-Yao Hu, Ping Ji, Jian Xiao, Xiao-Ling Wang
A novel alkaloid caulophyine A (1) was isolated from the roots of Caulophyllum robustum Maxim., along with six known alkaloids 2-7. The structure of 1 was elucidated by extensive NMR and high resolution-time-of-flight (HR-TOF)-MS analyses, it is a rare nitrogen containing polycyclic aromatic hydrocarbon. The in vitro bioassays revealed that 2 presented remarkable cytotoxicity against A549 with an IC50 value of 3.83 µM in comparison with the positive control etoposide (IC50  = 11.63 µM). Compounds 1 and 2 also displayed weak Acetylcholinesterase (AChE) inhibitory activity with IC50 values of 123...
2022: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/34122597/metabolomic-analysis-of-the-urine-from-rats-with-collagen-induced-arthritis-with-the-effective-part-of-caulophyllum-robustum-maxim
#8
JOURNAL ARTICLE
Shaowa Lü, Mingtao Zhu, Qiaoxin Guo, Dan Xu, Yuyan Guo, Guoyu Li, Qiuhong Wang, Haixue Kuang
Rheumatoid arthritis (RA) is a chronic autoimmune disease with high incidence and high disability and recurrence rates. Caulophyllum robustum Maxim ( C. robustum ) is a traditional Chinese medicine (TCM) with main effective parts (CRME) commonly used for RA treatment. To explore the mechanism of CRME in RA, we used metabolomics to investigate the effect of CRME intervention on urine metabolism in rats with collagen-induced arthritis (CIA). CIA rats were randomly divided into normal control, CIA model, and CRME groups...
2021: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/33496857/diversity-of-petals-in-berberidaceae-development-micromorphology-and-structure-of-floral-nectaries
#9
JOURNAL ARTICLE
Shan Su, Liang Zhao, Yi Ren, Xiao-Hui Zhang
Petals are important floral organs that exhibit considerable morphological diversity in terms of colour, shape, and size. The varied morphologies of mature petals can be linked to developmental differences. The petals of Berberidaceae (a core group of Ranunculales) range from flat sheets to complex structures with nectaries, but studies on petal development and structural diversity in this group are lacking. Here, the petal development, structure, and micromorphology of seven Berberidaceae genera are characterized by microscopy to clarify the diversity of petals within this group...
January 26, 2021: Protoplasma
https://read.qxmd.com/read/32029347/hplc-ms-ms-method-for-the-determination-and-pharmacokinetic-study-of-six-compounds-against-rheumatoid-arthritis-in-rat-plasma-after-oral-administration-of-the-extract-of-caulophyllum-robustum-maxim
#10
JOURNAL ARTICLE
Yuyan Guo, Shaowa Lü, Bingyou Yang, Guoyu Li, Wenbao Ma, Qiaoxin Guo, Qiuhong Wang, Haixue Kuang
Caulophyllum robustum Maxim (CRM) is a well-known traditional Chinese medicine (TCM) mainly present in the northeast, northwest and southwest regions of China, which is belong to the family Berberidaceae. The roots and rhizomes of CRM have been used as a famous TCM for the treatment of rheumatoid arthritis (RA). The selective, sensitive and accurate high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS) method for the determination and pharmacokinetic study cauloside H, leonticin D, cauloside G, cauloside D, cauloside C and magnoflorine in rat plasma was developed and validated in this paper...
October 21, 2019: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/31521702/mechanism-of-caulophyllum-robustum-maxim-against-rheumatoid-arthritis-using-lncrna-mrna-chip-analysis
#11
JOURNAL ARTICLE
Shaowa Lü, Yutian Liu, Jie Cui, Bingyou Yang, Guoyu Li, Yuyan Guo, Haixue Kuang, Qiuhong Wang
BACKGROUND: Caulophyllum robustum Maxim (CRM) is a medicinal compound of the Northeast and is commonly used in China for the treatment of rheumatic pain and rheumatoid arthritis (RA). A preliminary study found that CRM has good anti-inflammatory, analgesic and immunosuppressive effects. However, the specific links and targets for its function remain unclear. Our study aimed to provide a mechanism for the action of Caulophyllum robustum Maxim extraction (CRME) against RA and to establish a method for studying disease treatment using Chinese medicine...
September 12, 2019: Gene
https://read.qxmd.com/read/31496278/analysis-of-bioactive-components-and-pharmacokinetics-of-caulophyllum-robustum-in-rat-plasma-after-oral-administration-by-uplc-esi-ms-ms
#12
JOURNAL ARTICLE
Ji-Xin Duan, Guo-Yu Li, Shao-Wa Lü, Hong Su, Dan Xu, Yu-Yan Guo, Hai-Xue Kuang, Qiu-Hong Wang
A UPLC-MS/MS method was developed and validated the determination and pharmacokinetic study of magnoflorine, cauloside C, hederagenin, and oleanolic acid from Caulophyllum robustum . Digoxin was used as the internal standard. The pretreated plasma samples were carried out on a Waters ACQUITYUPLC HSS T3 column at 35 °C with a mobile phase of acetonitrile-water (90:10, v/v) at a flow rate of 0.2 mL/min. This article describes the most simple, sensitive, and validated UPLC-MS/MS method to date for the simultaneous successful determination of four compounds in rat plasma after oral administration of the extract of C...
September 9, 2019: Journal of Asian Natural Products Research
https://read.qxmd.com/read/30576974/a-generic-strategy-based-on-gas-phase-decomposition-of-protonated-and-ammoninted-precursors-producing-predictable-mrm-ms-ion-pairs-and-collision-energies-for-direct-analysis-of-plant-triterpene-glycosides
#13
JOURNAL ARTICLE
Yong-Gang Xia, Xin-Dong Guo, Yan Song, Jun Liang, Feng-Qiu Gong, Tian-Long Wang, Bing-You Yang, Hai-Xue Kuang
Optimization of multiple reaction monitoring mass spectrometry (MRM-MS) parameters of triterpene glycosides (TGs) using traditional infusion methods remains to be labor-intensive. However, it was found that mild gas phase decompositions of protonated and ammoninted precursors (DPAP) of TGs could produce a series of abundant dehydrated product ions of aglycones ([A+H-nH2 O]+ (n = 0, 1, 2, 3…)) with high efficiency and stability. Based on these considerations and findings, an innovative ESI+ -MRM-DPAP-MS strategy was devised on a QTRAP 4000 instrument allowing for rapid the qualitative and quantitative analysis of plant TGs...
December 11, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/30056184/piperidine-alkaloids-and-xanthone-from-the-roots-of-caulophyllum-robustum-maxim
#14
JOURNAL ARTICLE
Hui-Xiang Yang, Wei Li, Qian Li, Hong-Lian Ai, Zheng-Hui Li, Rong Huang, Tao Feng, Ji-Kai Liu
Two undescribed piperidine racemates, (±)-caulophines A and B (1 and 2), a new N-containing xanthone derivative (3), together with six known piperidines, were isolated from the roots of Caulophyllum robustum Maxim. Their structures were determined by extensive spectroscopic techniques. Compounds 3 and 7 exhibited weak cytotoxicities against human palace cancer hela cell line with inhibitory rates of 32.2% and 39.7%, respectively, at the concentration of 40 μM.
July 26, 2018: Fitoterapia
https://read.qxmd.com/read/29751627/anti-inflammatory-triterpenoids-from-the-caulophyllum-robustum-maximin-lps-stimulated-raw264-7-cells
#15
JOURNAL ARTICLE
Bin-Hua Qin, Xin-Qiao Liu, Qiao-Yu Yuan, Jing Wang, Hai-Yan Han
Caulophyllum robustum Maxim is widely distributed in China and used as a traditional herbal medicine to induce childbirth, ease the pain of labor, rectify delayed or irregular menstruation, alleviate heavy bleeding and pain during menstruation, and treat external injuries and irregular menses. According to our detailed chemical investigation, three new triterpene derivatives ( 1 ⁻ 3 ), together with seven known compounds, were isolated from the root and rhizome of C. robustum Maxim. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analysis and physio-chemical methods...
May 11, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/29072610/spectrum-effect-relationships-between-fingerprints-of-caulophyllum-robustum-maxim-and-inhabited-pro-inflammation-cytokine-effects
#16
JOURNAL ARTICLE
Shaowa Lü, Shuyu Dong, Dan Xu, Jixin Duan, Guoyu Li, Yuyan Guo, Haixue Kuang, Qiuhong Wang
Caulophyllum robustum Maxim (CRM) is a Chinese folk medicine with significant effect on treatment of rheumatoid arthritis (RA). This study was designed to explore the spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and the anti-inflammatory effects of CRM. Seventeen common peaks were detected by fingerprint similarity evaluation software. Among them, 15 peaks were identified by Liquid Chromatography-Mass Spectrometry (LC-MS). Pharmacodynamics experiments were conducted in collagen-induced arthritis (CIA) mice to obtain the anti-inflammatory effects of different batches of CRM with four pro-inflammation cytokines (TNF-α, IL-β, IL-6, and IL-17) as indicators...
October 26, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/28981338/heart-toxicity-related-to-herbs-and-dietary-supplements-online-table-of-case-reports-part-4-of-5
#17
REVIEW
Amy C Brown
BACKGROUND: The purpose of this review was to create an online research summary table of heart toxicity case reports related to dietary supplements (DS; includes herbs). METHODS: Documented PubMed case reports of DS appearing to contribute to heart-related problems were used to create a "Toxic Table" that summarized the research (1966 to April, 2016, and cross-referencing). Keywords included "herb," "dietary supplement," and cardiac terms. Case reports were excluded if they were herb combinations (some exceptions), Chinese herb mixtures, teas of mixed herb contents, mushrooms, poisonous plants, self-harm (e...
July 4, 2018: Journal of Dietary Supplements
https://read.qxmd.com/read/28306172/genetic-divergence-with-ongoing-gene-flow-is-maintained-by-the-use-of-different-hosts-in-phytophagous-ladybird-beetles-genus-henosepilachna
#18
JOURNAL ARTICLE
K W Matsubayashi, T I Kohyama, N Kobayashi, S Yamasaki, M Kuwajima, H Katakura
Adaptation to different environments can promote population divergence via natural selection even in the presence of gene flow - a phenomenon that typically occurs during ecological speciation. To elucidate how natural selection promotes and maintains population divergence during speciation, we investigated the population genetic structure, degree of gene flow and heterogeneous genomic divergence in three closely related Japanese phytophagous ladybird beetles: Henosepilachna pustulosa, H. niponica and H. yasutomii...
June 2017: Journal of Evolutionary Biology
https://read.qxmd.com/read/28050900/planned-early-birth-versus-expectant-management-waiting-for-prelabour-rupture-of-membranes-at-term-37-weeks-or-more
#19
REVIEW
Philippa Middleton, Emily Shepherd, Vicki Flenady, Rosemary D McBain, Caroline A Crowther
BACKGROUND: Prelabour rupture of membranes (PROM) at term is managed expectantly or by planned early birth. It is not clear if waiting for birth to occur spontaneously is better than intervening, e.g. by inducing labour. OBJECTIVES: The objective of this review is to assess the effects of planned early birth (immediate intervention or intervention within 24 hours) when compared with expectant management (no planned intervention within 24 hours) for women with term PROM on maternal, fetal and neonatal outcomes...
January 4, 2017: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/27383264/energy-resolved-technique-for-discovery-and-identification-of-malonyl-triterpene-saponins-in-caulophyllum-robustum-by-uhplc-electrospray-fourier-transform-mass-spectrometry
#20
JOURNAL ARTICLE
Yong-Gang Xia, Jun Liang, Guo-Yu Li, Bing-You Yang, Hai-Xue Kuang
Malonyl-triterpene saponins (MTSs) attract scientific attentions because of their structural diversities and valuable bioactivities. However, its thermal instability brings a huge amount of challenges for isolation and purification of this class of compounds. To our best knowledge, there has been no report on isolation and analysis of MTSs from genus Caulophyllum. In this study, a strategy combining data acquisition using an energy-resolved technique and the narrow widow extracted ion chromatograms as data mining method was developed for discovery and identification of MTSs in Caulophyllum robustum hair roots by ultra high liquid chromatography coupled to electrospray ionization Fourier transform mass spectrometry...
October 2016: Journal of Mass Spectrometry: JMS
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