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https://www.readbyqxmd.com/read/27383264/energy-resolved-technique-for-discovery-and-identification-of-malonyl-triterpene-saponins-in-caulophyllum-robustum-by-uhplc-electrospray-fourier-transform-mass-spectrometry
#1
Yong-Gang Xia, Jun Liang, Guo-Yu Li, Bing-You Yang, Hai-Xue Kuang
Malonyl-triterpene saponins (MTSs) attract scientific attentions due to their structural diversities and valuable bioactivities. However, its thermal instability brings a huge amount of challenges for isolation and purification of this class of compounds. To our best knowledge, there has been no report on isolation and analysis of MTSs from genus Caulophyllum. In this study, a strategy combining data acquisition using an energy-resolved technique and the narrow widow extracted ion chromatograms as data mining method, was developed for discovery and identification of MTSs in C...
July 6, 2016: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/25982196/analysis-of-oligosaccharide-sequences-of-trace-caulophyllum-robustum-saponins-by-direct-infusion-multiple-stage-tandem-mass-spectrometry
#2
Yong-Gang Xia, Jun Liang, Guo-Yu Li, Bing-You Yang, Hai-Xue Kuang
The saponins in Caulophyllum robustum have not yet been fully characterized. Furthermore these saponins are often present in trace amounts and are structurally complex. Here, a simple direct infusion electrospray ion trap multiple-stage tandem mass spectrometry (DI-ESI-IT-MS(n)) method was described for the characterization of trace C. robustum saponins. Eight reference saponins from the C. robustum hairy root were investigated by DI-ESI-IT-MS(n) in positive ion mode. Some fragmentation approaches were proposed through analysis of the [M+Na](+) ions: (1) preferential cleavage of the C-28 ester glycosidic bond to provide complementary [Y0α+Na](+) and [Bα+Na](+) ions for bidesmosidic saponins; (2) diagnostically neutral loss of CO2 from free carboxyl groups at C-28 for monodesmosidic saponins; and (3) the ion intensity ratio between [C2β+Na](+) and [B2β+Na](+), which is sensitive to the structural differences between the two isomeric β-sugar chains (Glc → (2)Ara and Glc → (3)Ara)...
August 10, 2015: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/25194340/a-strategy-for-characterization-of-triterpene-saponins-in-caulophyllum-robustum-hairy-roots-by-liquid-chromatography-with-electrospray-ionization-quadrupole-time-of-flight-mass-spectrometry
#3
Yong-Gang Xia, Guo-Yu Li, Jun Liang, Catharine A Ortori, Bing-You Yang, Hai-Xue Kuang, David A Barrett
Triterpene saponins are important bioactive constituents widely distributed in many plants. Saponins present in Caulophyllum (Berberidaceae) have not been fully characterized. In this study, we studied triterpene saponins from Caulophyllum robustum using liquid chromatography combined with electrospray ionization quadrupole time-of-flight mass spectrometry (LC-qTOF-MS). Rapid identification of Caulophyllum saponins was facilitated using low and high MS cone voltages to induce controlled fragmentation in positive mode...
November 2014: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/24876877/genus-caulophyllum-an-overview-of-chemistry-and-bioactivity
#4
REVIEW
Yong-Gang Xia, Guo-Yu Li, Jun Liang, Bing-You Yang, Shao-Wa Lü, Hai-Xue Kuang
Recently, some promising advances have been achieved in understanding the chemistry, pharmacology, and action mechanisms of constituents from genus Caulophyllum. Despite this, there is to date no systematic review of those of genus Caulophyllum. This review covers naturally occurring alkaloids and saponins and those resulting from synthetic novel taspine derivatives. The paper further discussed several aspects of this genus, including pharmacological properties, mechanisms of action, pharmacokinetics, and cell membrane chromatography for activity screening...
2014: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/24328138/toxins-in-botanical-dietary-supplements-blue-cohosh-components-disrupt-cellular-respiration-and-mitochondrial-membrane-potential
#5
Sandipan Datta, Fakhri Mahdi, Zulfiqar Ali, Mika B Jekabsons, Ikhlas A Khan, Dale G Nagle, Yu-Dong Zhou
Certain botanical dietary supplements have been associated with idiosyncratic organ-specific toxicity. Similar toxicological events, caused by drug-induced mitochondrial dysfunction, have forced the withdrawal or U.S. FDA "black box" warnings of major pharmaceuticals. To assess the potential mitochondrial liability of botanical dietary supplements, extracts from 352 authenticated plant samples used in traditional Chinese, Ayurvedic, and Western herbal medicine were evaluated for the ability to disrupt cellular respiration...
January 24, 2014: Journal of Natural Products
https://www.readbyqxmd.com/read/23472485/adverse-effects-of-herbal-medicines-an-overview-of-systematic-reviews
#6
REVIEW
Paul Posadzki, Leala K Watson, Edzard Ernst
This overview of systematic reviews (SRs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (HMs). Five electronic databases were searched to identify all relevant SRs, with 50 SRs of 50 different HMs meeting our inclusion criteria. Most had only minor weaknesses in methods. Serious adverse effects were noted only for four HMs: Herbae pulvis standardisatus, Larrea tridentate, Piper methysticum and Cassia senna. The most severe adverse effects were liver or kidney damage, colon perforation, carcinoma, coma and death...
February 2013: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/23420136/primary-constituents-of-blue-cohosh-quantification-in-dietary-supplements-and-potential-for-toxicity
#7
REVIEW
Jeanne I Rader, Rahul S Pawar
Dietary supplements containing dried roots or extracts of the roots and/or rhizomes of blue cohosh (Caulophyllum thalictroides) are widely available. This botanical has a long history of use by Native Americans and its use continues to the present day. The primary constituents of blue cohosh are its alkaloids and saponins. The structures of the alkaloids magnoflorine, baptifoline, anagyrine, and N-methylcytisine have been known for many years. The last 10 years have seen a great increase in isolation and identification of the large number of saponins present in blue cohosh...
May 2013: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/22988475/anti-inflammatory-effect-of-triterpene-saponins-isolated-from-blue-cohosh-caulophyllum-thalictroides
#8
Yeonju Lee, Jae-Chul Jung, Zulfiqar Ali, Ikhlas A Khan, Seikwan Oh
Blue cohosh has been used as a medicinal herb in eastern North America. It was commonly used as traditional medicines for the treatment of menopausal symptoms, rheumatic pain, and as anti-inflammatory remedy. Particularly, extract of blue cohosh roots has been used as anti-inflammatory antipyretic in traditional medicines. In the present study, we investigated the effects of blue cohosh components on the suppressive expression of iNOS or proinflammatory cytokines after the activation of microglia with lipopolysaccharide (LPS)...
2012: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/22066407/-effect-of-taspine-derivatives-on-human-liver-cancer-smmc7721
#9
Yan-min Zhang, Nan Wang, Bing-ling Dai, Lang-chong He
OBJECTIVE: To analyse the inhibition effect of taspine derivatives on human Liver cancer SMMC7721 cell and its mechanism. METHODS: The effects of five taspine derivatives on SMMC7721 cell growth were determined by MTT. The flow cytometry was used to determine the cell cycle. The effects of Tas-D1 on the EGF and VEGF in SMMC7721 cell were determined by ELISA. The mRNA level of EGF and VEGF in SMMC7721 cell was determined by RT-PCR. RESULTS: The MTT assay demonstrated that the taspine derivative Tas-D1 significantly inhibited the growth of SMMC7721 cell in a dose-dependent manner...
July 2011: Zhong Yao Cai, Zhongyaocai, Journal of Chinese Medicinal Materials
https://www.readbyqxmd.com/read/21872415/analytical-methods-for-determination-of-magnoflorine-and-saponins-from-roots-of-caulophyllum-thalictroides-l-michx-using-uplc-hplc-and-hptlc
#10
Bharathi Avula, Yan-Hong Wang, Chidananda Swamy Rumalla, Zulfiqar Ali, Troy J Smillie, Ikhlas A Khan
Analytical methods including HPLC, UPLC and HPTLC are presented for the determination of major alkaloid and triterpene saponins from the roots of Caulophyllum thalictroides (L.) Michx. (blue cohosh) and dietary supplements claiming to contain blue cohosh. A separation by LC was achieved using a reversed phase column, PDA with ELS detection, and ammonium acetate/acetonitrile gradient as the mobile phase. Owing to their low UV absorption, the triterpene saponins were detected by evaporative light scattering. The eight triterpene saponins (cauloside H, leonticin D, cauloside G, cauloside D, cauloside B, cauloside C, cauloside A and saponin PE) and the alkaloid magnoflorine could be separated within 35 min using HPLC method and within 8...
December 15, 2011: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/21596111/four-new-fluorenone-alkaloids-and-one-new-dihydroazafluoranthene-alkaloid-from-caulophyllum-robustum-maxim
#11
Xiao-Ling Wang, Bing-Rui Liu, Chien-Kuang Chen, Jun-Ru Wang, Shoei-Sheng Lee
Four new fluorenone alkaloids, caulophylline A-D (1-4), and one new dihydroazafluoranthene alkaloid, caulophylline E (5) were isolated from the roots of Caulophyllum robustum Maxim. Their structures were elucidated by spectroscopic analysis. Among the isolated alkaloids, Caulophylline E showed good scavenging effects against DPPH radical with IC(50) of 39 μM.
September 2011: Fitoterapia
https://www.readbyqxmd.com/read/21259434/establishment-of-a431-cell-membrane-chromatography-rplc-method-for-screening-target-components-from-radix-caulophylli
#12
Xiaofang Hou, Sicen Wang, Jingjing Hou, Langchong He
We describe here an analytical method of A431 cell membrane chromatography (A431/CMC) (CMC, cell membrane chromatography) combined with RPLC for recognition, separation, and identification of target components from traditional Chinese medicines (TCMs) Radix Caulophylli. The A431 cells with high expressed epidermal growth factor receptor (EGFR) were used to prepare the stationary phase in the CMC model. Retention fractions on the A431-CMC model were collected using an automated fraction collection and injection module (FC/I)...
March 2011: Journal of Separation Science
https://www.readbyqxmd.com/read/20829129/a-combined-a431-cell-membrane-chromatography-and-online-high-performance-liquid-chromatography-mass-spectrometry-method-for-screening-compounds-from-total-alkaloid-of-radix-caulophylli-acting-on-the-human-egfr
#13
Meng Sun, Jing Ren, Hui Du, Yanmin Zhang, Jie Zhang, Sicen Wang, Langchong He
We have developed an online analytical method that combines A431 cell membrane chromatography (A431/CMC) with high performance liquid chromatography and mass spectrometry (LC/MS) for identifying active components from Radix Caulophylli acting on human EGFR. Retention fractions on A431/CMC model were captured onto an enrichment column and the components were directly analyzed by combining a 10-port column switcher with an LC/MS system for separation and preliminary identification. Using Sorafenib tosylate as a positive control, taspine and caulophine from Radix Caulophylli were identified as the active molecules which could act on the EGFR...
October 15, 2010: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/20724803/caulophine-protects-cardiomyocytes-from-oxidative-and-ischemic-injury
#14
Kaiwei Si, Juntian Liu, Langchong He, Xikuan Li, Wei Gou, Chuanhao Liu, Xiaoqi Li
Caulophine is a new fluorenone alkaloid isolated from the radix of Caulophyllum robustum MAXIM and identified as 3-(2-(dimethylamino) ethyl)-4,5-dihydroxy-1,6-dimethoxy-9H-fluoren-9-one. Due to its new chemical structure, the pharmacological activities of caulophine are not well characterized. The present study evaluated the protective effect and the primary mechanisms of caulophine on cardiomyocyte injury. Viability of cardiomyocytes was assayed with the MTT method, and cell apoptosis was detected by flow cytometry...
2010: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/20707411/teratogenic-effects-of-blue-cohosh-caulophyllum-thalictroides-in-japanese-medaka-oryzias-latipes-are-probably-mediated-through-gata2-edn1-signaling-pathway
#15
Minghui Wu, Yuhui Hu, Zulfiqar Ali, Ikhlas A Khan, A J Verlangeiri, Asok K Dasmahapatra
Blue cohosh (Caulophyllum thalictroides) (BC) has been used widely to induce labor and to treat other uterine conditions. However, the safety and effectiveness of this herbal product has not yet been evaluated by the US Food and Drug Administration (FDA). Several conflicting reports indicated that the root extract of BC is a teratogen and, by some unknown mechanisms, is able to induce cardiovascular malfunctions in new-born babies. To understand the mechanism, we have used Japanese medaka (Oryzias latipes) embryo-larval development as the experimental model and the methanolic extract of BC root as the teratogen...
August 16, 2010: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/20649558/effects-of-caulophine-on-caffeine-induced-cellular-injury-and-calcium-homeostasis-in-rat-cardiomyocytes
#16
Kai-Wei Si, Jun-Tian Liu, Lang-Chong He, Xi-Kuan Li, Wei Gou, Chuan-Hao Liu, Xiao-Qi Li
Caulophine is a novel fluorenone alkaloid isolated from the radix of Caulophyllum robustum Maxim. Caulophine showed high affinity for the rat myocardial cell membrane as assessed by cell membrane chromatography, suggesting that the compound may exert bioactivity in the heart. It is known that calcium plays an important role in the pathogenesis of ischaemic heart disease, and caffeine can cause calcium overload in cardiomyocytes by inducing calcium release from the sarcoplasmic reticulum. Therefore, the present study evaluated the effects of caulophine on caffeine-induced injury and calcium homeostasis in cardiomyocytes...
December 2010: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/20004544/a-combined-cell-membrane-chromatography-and-online-hplc-ms-method-for-screening-compounds-from-radix-caulophylli-acting-on-the-human-alpha-1a-adrenoceptor
#17
Lan Wang, Jing Ren, Meng Sun, Sicen Wang
We have developed an online analytical method that combines alpha(1A)-adrenoceptor (alpha(1A)AR) cell membrane chromatography (alpha(1A)AR-CMC) with high performance liquid chromatography and mass spectrometry (HPLC/MS) for the identification of active components from Radix Caulophylli acting on the human alpha(1A)AR. Fractions retained by the alpha(1A)AR-CMC column were captured into a loop and the components were directly analyzed by combining an 8 port column switcher with an HPLC/MS system for separation and preliminary identification...
April 6, 2010: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/19778187/nicotinic-plant-poisoning
#18
REVIEW
Leo J Schep, Robin J Slaughter, D Michael G Beasley
INTRODUCTION: A wide range of plants contain nicotinic and nicotinic-like alkaloids. Of this diverse group, those that have been reported to cause human poisoning appear to have similar mechanisms of toxicity and presenting patients therefore have comparable toxidromes. This review describes the taxonomy and principal alkaloids of plants that contain nicotinic and nicotinic-like alkaloids, with particular focus on those that are toxic to humans. The toxicokinetics and mechanisms of toxicity of these alkaloids are reviewed and the clinical features and management of poisoning due to these plants are described...
September 2009: Clinical Toxicology
https://www.readbyqxmd.com/read/19720119/leiyemudanosides-a-c-three-new-bidesmosidic-triterpenoid-saponins-from-the-roots-of-caulophyllum-robustum
#19
Guoyu Li, Yanhai Zhang, Bingyou Yang, Yonggang Xia, Yanlong Zhang, Shaowa Lü, Haixue Kuang
Three new oleanane bidesmosidic triterpenoid saponins, named leiyemudanosides A-C (1-3) were isolated from the roots of Caulophyllum robustum Maxim. Their structures were established by chemical and detailed spectroscopic analysis as 3-O-alpha-L-arabinopyranosyl-caulophyllogenin-28-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester (1), 3-O-beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranosyl-caulophyllogenin-28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester (2), and 3-O-beta-D-glucopyranosyl-(1-->3)-alpha-L-arabinopyranosyl-echinocystic acid-28-O-alpha-L-rhamnopyranosyl-(1-->4)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester (3), respectively...
April 2010: Fitoterapia
https://www.readbyqxmd.com/read/19449879/triterpene-glycosides-from-the-underground-parts-of-caulophyllum-thalictroides
#20
Yukiko Matsuo, Kazuki Watanabe, Yoshihiro Mimaki
A total of 22 triterpene glycosides, including 10 new compounds (1-10), were isolated from the underground parts of Caulophyllum thalictroides. The structures of the new glycosides were determined on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR data, and of hydrolytic cleavage followed by chromatographic or spectroscopic analyses. All 22 compounds were evaluated for cytotoxicity against HL-60 human leukemia cells. The triterpene monodesmosides based on oleanolic acid (1 and 11-16) showed cytotoxic activity against HL-60 cells with IC(50) values that ranged from 3...
June 2009: Journal of Natural Products
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