Mariane Meurer, Fabiula Felisbino, Fabiana B Müller, Lincon B Somensi, Benhur J Cury, Daniele T Jerônimo, Larissa Venzon, Tauani C S França, Marihá Mariott, Ana C Santos, Ruan Kaio S Nunes, Thaise Boeing, Alexandre Bella-Cruz, Priscila DE Souza, Walter A Roman-Junior, Karuppusamy Arunachalam, Ruberlei G Oliveira, Luisa M Silva
The antiulcer mechanisms of the dry extract of T. erecta flowers (DETe) were studied here. The acute ulcers induced by acidified ethanol or indomethacin were reproduced in mice pretreated with DETe (3 - 300 mg/kg). The antiulcer activity of DETe was also verified in mice pretreated with NEM, L-NAME, indomethacin, or yohimbine. The antisecretory effect of DETe was verified in rats, and its anti-Helicobacter pylori activity was determined in vitro. DETe (300 mg/kg, p.o) reduced the ethanol- or indomethacin-induced ulcer by 49 and 93%, respectively...
2023: Anais da Academia Brasileira de Ciências