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https://www.readbyqxmd.com/read/28729463/dietary-pufas-attenuate-nlrp3-inflammasome-activation-via-enhancing-macrophage-autophagy
#1
Lulu Shen, Yan Yang, Tiantong Ou, Chia-Chi C Key, Sarah H Tong, Russel C Sequeira, Jonathan M Nelson, Yan Nie, Zhan Wang, Elena Boudyguina, Swapnil V Shewale, Xuewei Zhu
Dietary PUFAs reduce atherosclerosis and macrophage inflammation, but how NLRP3 inflammasome activation and autophagy influence PUFA-mediated atheroprotection is poorly understood. We fed Ldlr-/- mice diets containing 10% (calories) palm oil (PO) and 0.2% cholesterol, supplemented with an additional 10% of calories as PO, fish oil (FO), echium oil (EO, containing 18:4 n-3), or borage oil (BO, containing 18:3 n-6). Inflammasome activation, autophagic flux, and mitochondrial function were measured in peritoneal macrophages, blood monocytes, or liver from diet-fed mice...
July 20, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28716422/development-of-imidazolinone-herbicide-tolerant-borage-borago-officinalis-l
#2
Dongyan Song, Guohai Wu, Patricia Vrinten, Xiao Qiu
Borage (Borago officinalis) is an annual herb that produces a high level of gamma-linolenic acid (GLA) in its seed oil. Due to the recognized health benefits of GLA, borage is now commercially cultivated worldwide. However, an herbicide-tolerant variety for effective weed management has not yet been developed. Here we report the generation and characterization of ethyl methanesulfonate (EMS) induced borage mutant lines tolerant to the herbicide imidazolinone. An EMS-mutagenized borage population was generated by using a series of concentrations of EMS to treat mature borage seeds...
September 2017: Plant Science: An International Journal of Experimental Plant Biology
https://www.readbyqxmd.com/read/28686292/microencapsulation-of-borage-oil-with-blends-of-milk-protein-%C3%AE-glucan-and-maltodextrin-through-spray-drying-physicochemical-characteristics-and-stability-of-the-microcapsules
#3
Ru-Yi Li, Yan Shi
BACKGROUND: Borage oil is a rich commercial source of gamma-linolenic acid (GLA, 18:3n-6). However, borage oil is rich in omega-6 polyunsaturated fatty acids and vulnerable to oxidation. Thus, selecting of appropriate wall materials is critical to the encapsulation of borage oil. This study investigated the influence of wall materials on the physicochemical characteristics and stability of microencapsulated borage oil by spray drying. Blends of milk protein [sodium caseinate (CAS) or whey protein concentrate (WPC)], β-glucan (GLU) and maltodextrin (MD) were used as the wall materials for encapsulating borage oil...
July 7, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28638880/efficiency-of-borage-seeds-oil-against-gamma-irradiation-induced-hepatotoxicity-in-male-rats-possible-antioxidant-activity
#4
Hala A H Khattab, Inas Z A Abdallah, Fatimah M Yousef, Etimad A Huwait
BACKGROUND: Borage (Borago officinal L.) is an annual herbaceous plant of great interest because its oil contains a high percentage of γ-linolenic acid (GLA). The present work was carried out to detect fatty acids composition of the oil extracted from borage seeds (BO) and its potential effectiveness against γ-irradiation- induced hepatotoxicity in male rats. MATERIALS AND METHODS: GC-MS analysis of fatty acids methyl esters of BO was performed to identify fatty acids composition...
2017: African Journal of Traditional, Complementary, and Alternative Medicines: AJTCAM
https://www.readbyqxmd.com/read/28638392/evaluation-of-borage-extracts-as-potential-biostimulant-using-a-phenomic-agronomic-physiological-and-biochemical-approach
#5
Roberta Bulgari, Silvia Morgutti, Giacomo Cocetta, Noemi Negrini, Stefano Farris, Aldo Calcante, Anna Spinardi, Enrico Ferrari, Ilaria Mignani, Roberto Oberti, Antonio Ferrante
Biostimulants are substances able to improve water and nutrient use efficiency and counteract stress factors by enhancing primary and secondary metabolism. Premise of the work was to exploit raw extracts from leaves (LE) or flowers (FE) of Borago officinalis L., to enhance yield and quality of Lactuca sativa 'Longifolia,' and to set up a protocol to assess their effects. To this aim, an integrated study on agronomic, physiological and biochemical aspects, including also a phenomic approach, has been adopted...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28499255/identification-of-an-aspidospermine-derivative-from-borage-extract-as-an-anti-amyloid-compound-a-possible-link-between-protein-aggregation-and-antimalarial-drugs
#6
Hamid R Kalhor, Hossein Ashrafian
A number of human diseases, including Alzheimer's and Parkinson's have been linked to amyloid formation. To search for an anti-amyloidogenic product, alkaloid enriched extract from borage leaves was examined for anti-amyloidogenic activity using Hen Egg White Lysozyme (HEWL) as a model protein. After isolation of the plant extract using rHPLC, only one fraction indicated a significant bioactivity. TEM analysis confirmed a remarkable reduction of amyloid fibrils in the presence of the bioactive fraction. To identify the effective substance in the fraction, mass spectrometry, FTIR, and NMR were performed...
August 2017: Phytochemistry
https://www.readbyqxmd.com/read/28285116/effect-of-borage-and-green-tea-aqueous-extracts-on-the-quality-of-lamb-leg-chops-displayed-under-retail-conditions
#7
M Bellés, V Alonso, P Roncalés, J A Beltrán
Different concentrations of two aqueous extracts from green tea leaves and borage seeds with potential antioxidant activity were evaluated in lamb leg chops. Chops were sprayed with 0.005, 0.05, 0.5, 5% (p/v) green tea extracts (T) and 0.5, 5 and 10% (p/v) borage seed extracts (B) and displayed under retail conditions for 13days. Total polyphenols, TBARS, colour, microbial and sensory analyses were performed. The extracts showed a concentration-dependent action; the minimum concentration of polyphenols which significantly reduced lipid oxidation was 2...
July 2017: Meat Science
https://www.readbyqxmd.com/read/28197106/inhibition-of-intermediate-conductance-calcium-activated-k-channel-kca3-1-and-fibroblast-mitogenesis-by-%C3%AE-linolenic-acid-and-alterations-of-channel-expression-in-the-lysosomal-storage-disorders-fabry-disease-and-niemann-pick-c
#8
Aida Oliván-Viguera, Javier Lozano-Gerona, Laura López de Frutos, Jorge J Cebolla, Pilar Irún, Edgar Abarca-Lachen, Ana J García-Malinis, Ángel Luis García-Otín, Yolanda Gilaberte, Pilar Giraldo, Ralf Köhler
The calcium/calmodulin-gated KCa3.1 channel regulates normal and abnormal mitogenesis by controlling K(+)-efflux, cell volume, and membrane hyperpolarization-driven calcium-entry. Recent studies suggest modulation of KCa3.1 by omega-3 fatty acids as negative modulators and impaired KCa3.1 functions in the inherited lysosomal storage disorder (LSD), Fabry disease (FD). In the first part of present study, we characterize KCa3.1 in murine and human fibroblasts and test the impact of omega-3 fatty acids on fibroblast proliferation...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28153304/in-pipette-solid-phase-extraction-prior-to-flow-modulation-comprehensive-two-dimensional-gas-chromatography-with-dual-detection-for-the-determination-of-minor-components-in-vegetable-oils
#9
Laura Barp, Flavio A Franchina, Giorgia Purcaro, Peter Q Tranchida, Luigi Mondello
The present research is based on the development of an effective, environmentally-friendly and low-cost method for investigation of minor components in vegetable oils, exploiting the advantages of a miniaturized solid-phase extraction (SPE) and the potential of flow modulation (FM) comprehensive two-dimensional gas chromatography (GC×GC), coupled to a mass spectrometer (MS) and a flame ionization detector (FID). The initial sample preparation step was carried out using a miniaturized approach characterized by a SPE process in a Pasteur pipette...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28112707/in-the-kingdom-of-tortelli-ravioli-like-pasta-plant-poisoning-is-still-a-threat-a-case-report-of-near-fatal-poisoning-from-digitalis-purpurea-accidentally-confused-with-borago-officinalis
#10
Laura Bonfanti, Giuseppe Lippi, Irene Ciullo, Fiorenza Robuschi, Rosalia Aloe, Sara Tarasconi, Riccardo Vassallo, Gianfranco Cervellin
A 58 years healthy old woman was admitted to the Emergency Department (ED) with cardiac arrest due to ventricular fibrillation (VF). Appropriate cardiopulmonary resuscitation (CPR), multiple DC shocks and oro-tracheal intubation (OTI) were effective to induce recovery of spontaneous circulation (ROSC). After ROSC was achieved, the electrocardiogram (ECG) showed an idio-ventricular rhythm with atrioventricular dissociation. A transcutaneous pacing was hence applied and the patient was administered with isoproterenol...
January 16, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/27904397/antibacterial-activity-of-indian-borage-plectranthus-amboinicus-benth-leaf-extracts-in-food-systems-and%C3%A2-against-natural-microflora-in-chicken-meat
#11
Sandeep Kumar Gupta, Pradeep Singh Negi
The ability of acetone and ethyl acetate extracts of the leaves of a traditional Indian medicinal plant, Indian borage (Plectranthus amboinicus Benth) to prevent spoilage of artificially inoculated model food systems (cabbage and papaya) and natural microflora of chicken meat was evaluated. These extracts were able to reduce the bacterial counts in all food systems; however, the effective concentration varied with the complexity of the system (cabbage<papaya<chicken). A probable mode of action of extracts was investigated by analyzing the changes they cause in bacterial cell wall and leakage of nucleic acid from bacterial cells...
March 2016: Food Technology and Biotechnology
https://www.readbyqxmd.com/read/27811230/in-vivo-activation-of-leukocyte-gpr120-ffar4-by-pufas-has-minimal-impact-on-atherosclerosis-in-ldl-receptor-knockout-mice
#12
Swapnil V Shewale, Amanda L Brown, Xin Bi, Elena Boudyguina, Janet K Sawyer, Martha A Alexander-Miller, John S Parks
G protein-coupled receptor (GPR)120/FFA receptor (FFAR)4 (GPR120/FFAR4) activation by n-3 PUFAs attenuates inflammation, but its impact on atherosclerosis is unknown. We determined whether in vivo activation of leukocyte GPR120/FFAR4 by n-3 versus n-6 PUFAs is atheroprotective. Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor KO background were generated by bone marrow transplantation. Mice were fed one of the four atherogenic diets containing 0.2% cholesterol and 10% calories as palm oil (PO) + 10% calories as: 1) PO, 2) fish oil (FO; 20:5 n-3 and 22:6 n-3 enriched), 3) echium oil (EO; 18:4 n-3 enriched), or 4) borage oil (BO; 18:3 n-6 enriched) for 16 weeks...
January 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/27743458/alkannin-inhibits-ccl3-and-ccl5-production-in-human-periodontal-ligament-cells
#13
Yoshitaka Hosokawa, Ikuko Hosokawa, Satoru Shindo, Yoshihiro Ohta, Kazumi Ozaki, Takashi Matsuo
Alkannin, which is found in Alkanna tinctoria, a member of the borage family, is used as a food coloring. Alkannin has recently been reported to have certain biological functions, such as anti-microbial and anti-oxidant effects. It is known that CC chemokine receptor (CCR) 5-positive leukocytes contribute to alveolar bone resorption in periodontal lesions. The aim of this study was to examine whether alkannin inhibits the production of CC chemokine ligand (CCL) 3 and CCL5, which are CCR5 ligands, in human periodontal ligament cells (HPDLC)...
December 2016: Cell Biology International
https://www.readbyqxmd.com/read/27664922/purification-of-polyphenol-oxidase-from-borage-trachystemon-orientalis-l-by-using-three-phase-partitioning-and-investigation-of-kinetic-properties
#14
Esma Hande Alici, Gulnur Arabaci
In this study a Polyphenol oxidase from borage plant was purified with 3.59-fold enrichment in the specific activity and 68.75% recovery of the total activity by using three-phase partitioning purification technique for the first time. Its molecular weight was found around 80kDa with sodium dodecyl sulfate polyacrylamide gel electrophoresis. The optimum pH and temperature values of the enzyme for the used four substrates ranged between the pH 5.0-7.5 and 5-30°C. The kcat/Km values showed that the enzyme has the greatest reactivity toward caffeic acid among the substrates used...
December 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/27648380/diet-and-eczema-a-review-of-dietary-supplements-for-the-treatment-of-atopic-dermatitis
#15
REVIEW
Megan J Schlichte, Abbey Vandersall, Rajani Katta
In the context of increasing popularity of "natural" alternatives to conventional medicine, several dietary supplements have gained the attention of researchers and consumers alike in the treatment of atopic dermatitis (AD). Readily available without a prescription and frequently perceived to have fewer side effects than traditional medications, these "natural" remedies may be featured in discussions with patients, and clinicians should therefore be familiar with their efficacy and safety. Based on trials to date, no dietary supplements can be recommended for routine use in the treatment of AD...
July 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27433586/association-of-borage-oil-and-betamethasone-dipropionate-in-lipid-core-nanocapsules-characterization-photostability-and-in-vitro-irritation-test
#16
Julia Weber, Nadine L Funk, Mariana H Motta, Alessandra M Guedes, Ana Paula C Visintainer, Solange B Tedesco, Cristiane de B Da Silva
The association of vegetable products to nanostructured systems has attracted the attention of researchers due to several advantages, such as drug photoprotection, as well as the improvement of the pharmacological and therapeutic activities because of synergistic action, which can provide their topical application. In this work, lipid-core nanocapsules containing borage oil as oil core and betamethasone dipropionate were developed, and nanocapsules without the drug were prepared for comparison. The suspensions were characterized in relation to mean particle size, zeta potential, pH, drug content, and encapsulation efficiency...
February 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27050790/borage-oil-attenuates-progression-of-cardiac-remodeling-in-rats-after-myocardial-infarction
#17
Julianne dos Santos Maldonado-Menetti, Taise Vitor, Rodrigo Camargo Leão Edelmuth, Fernanda Amá Ferrante, Pamella Ramona de Moraes Souza, Marcia Kiyomi Koike
PURPOSE: To investigate the effects of Borage oil on cardiac remodeling after myocardial infarction (MI). METHODS: Male Wistar rats underwent ligation of the left coronary artery and divided into three groups: MI (control), BO-18 (18 mg/kg of borage oil) and BO-180 (180 mg/kg of borage oil). After seven days, heart was arrested in diastole and processed for histological evaluation of: MI size, LV dilation, myocyte hypertrophy, inflammatory infiltration and fibrosis in MI region and in remote region...
March 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/26784875/extraction-of-antioxidants-from-borage-borago-officinalis-l-leaves-optimization-by-response-surface-method-and-application-in-oil-in-water-emulsions
#18
Francisco Segovia, Bryshila Lupo, Sara Peiró, Michael H Gordon, María Pilar Almajano
Borage (Borago officinalis L.) is a typical Spanish plant. During processing, 60% are leaves. The aim of this work is to model and optimize the extraction of polyphenol from borage leaves using the response surface method (RSM) and to use this extract for application in emulsions. The responses were: total polyphenol content (TPC), antioxidant capacity by ORAC, and rosmarinic acid by HPLC. The ranges of the variables temperature, ethanol content and time were 50-90 °C, 0%-30%-60% ethanol (v/v), and 10-15 min...
2014: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/26681356/fossil-nutlets-of-boraginaceae-from-the-continental-eocene-of-hamada-of-m%C3%A3-ridja-southwestern-algeria-the-first-fossil-of-the-borage-family-in-africa
#19
Sid Ahmed Hammouda, Maximilian Weigend, Fateh Mebrouk, Juliana Chacón, Mustapha Bensalah, Hans-Jürgen Ensikat, Mohammed Adaci
PREMISE OF THE STUDY: The Paleogene deposits of the Hamada of Méridja, southwestern Algeria, are currently dated as lower-to-middle Eocene in age based on fossil gastropods and charophytes. Here we report the presence of fruits that can be assigned to the Boraginaceae s.str., apparently representing the first fossil record for this family in Africa, shedding new light on the historical biogeography of this group. METHODS: Microscopic studies of the fossil nutlets were carried out and compared to extant Boraginaceae nutlets, and to types reported in the literature for this family...
December 2015: American Journal of Botany
https://www.readbyqxmd.com/read/26649166/the-antinociceptive-effects-of-hydroalcoholic-extract-of-borago-officinalis-flower-in-male-rats-using-formalin-test
#20
Mohammad Reza Shahraki, Mahdieh Ahmadimoghadm, Ahmad Reza Shahraki
INTRODUCTION: Borago officinalis flower (borage) is a known sedative in herbal medicine; the aim of the present study was to evaluate the antinociceptive effect of borage hydroalcoholic extract in formalin test male rats. METHODS: Fifty-six adult male albino Wistar rats were randomly divided into seven groups: Control groups of A (intact), B (saline), and C (Positive control) plus test groups of D, E, F, and G (n=8). The groups D, E, and F received 6.25, 12.5, and 25 mg/kg, Borago officinalis flower hydroalcholic extract before the test, respectively but group G received 25 mg/kg borage extract and aspirin before the test...
October 2015: Basic and Clinical Neuroscience
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