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Awantika Singh, Vikas Bajpai, Sunil Kumar, Ajay Kumar Singh Rawat, Brijesh Kumar
Mahonia leschenaultia (ML) and Mahonia napaulensis (MN) are less known and unexplored medicinal plants of the family Berberidaceae. They are used by the Todas of Nilgiris in their religious and medical practices but chemically less identified. Hence, we decided to do extensive phytochemical analysis to explore the potential of these plant extracts. An ultrahigh performance electrospray tandem mass spectrometry (UHPLC-ESI-MS/MS) method was successfully developed for qualitative analysis of the bioactive components in Mahonia species using Orbitrap Velos Pro mass spectrometer...
April 2017: Journal of Pharmaceutical Analysis
Dejan Gođevac, Ana Damjanović, Tatjana P Stanojković, Boban Anđelković, Gordana Zdunić
Herein, we propose a 1H NMR-based metabolomics method to reveal cytotoxic metabolites from Mahonia aquifolium stem-bark. Primary and secondary metabolites in the Mahonia aquifolium extracts were identified by thorough analysis of 1H and 2D NMR spectra, without prior isolation. An OPLS multivariate analysis method was used to correlate the chemical composition of the plant extracts with the results of cytotoxic activity against Human cervical adenocarcinoma cell line. Protoberberine alkaloids berberinе and palmatine, along with bisbenzylisoquinoline alkaloid berbamine were identified as the most influential in the OPLS model, with the highest cytotoxic activity...
December 1, 2017: Journal of Pharmaceutical and Biomedical Analysis
Zhiyu Wang, Neng Wang, Xiaoyan Liu, Qi Wang, Biao Xu, Pengxi Liu, Huayu Zhu, Jianping Chen, Honglin Situ, Yi Lin
Granulomatous lobular mastitis (GLM) is a type of chronic mammary inflammation with unclear etiology. Currently systematic corticosteroids and methitrexate are considered as the main drugs for GLM treatment, but a high toxicity and risk of recurrence greatly limit their application. It is therefore an urgent requirement that safe and efficient natural drugs are found to improve the GLM prognosis. Broadleaf Mahonia (BM) is a traditional Chinese herb that is believed to have anti‑inflammatory properties according to ancient records of traditional Chinese medicine...
November 9, 2017: International Journal of Molecular Medicine
Anna Och, Katarzyna Szewczyk, Łukasz Pecio, Anna Stochmal, Daniel Załuski, Anna Bogucka-Kocka
Cancer is one of the most occurring diseases in developed and developing countries. Plant-based compounds are still researched for their anticancer activity and for their quantity in plants. Therefore, the modern chromatographic methods are applied to quantify them in plants, for example, UPLC-MS/MS (ultraperformance liquid chromatography tandem mass spectrometry). Therefore, the aim of the present study was to evaluate the content of sanguinarine, berberine, protopine, and chelidonine in Dicentra spectabilis (L...
2017: Oxidative Medicine and Cellular Longevity
Congying Yuan, Meinan Wang, Daniel Z Skinner, Deven R See, Chongjing Xia, Xinhong Guo, Xianming Chen
Puccinia striiformis f. sp. tritici (Pst), the wheat stripe rust pathogen, is a dikaryotic, biotrophic, and macrocyclic fungus. Genetic study of Pst virulence was not possible until the recent discovery of Berberis spp. and Mahonia spp. as alternate hosts. To determine inheritance of virulence and map virulence genes, a segregating population of 119 isolates was developed by self-fertilizing Pst isolate 08-220 (race PSTv-11) on barberry leaves under controlled greenhouse conditions. The progeny isolates were phenotyped on a set of 29 wheat lines with single genes for race-specific resistance and genotyped with simple sequence repeat (SSR) markers, simple sequence repeat derived from secreted protein genes (SP-SNP), and SNP markers from genotyping- by-sequencing (GBS)...
September 6, 2017: Phytopathology
Mohamed L Ashour, Fadia S Youssef, Haidy A Gad, Michael Wink
BACKGROUND: Herbal medicine is widely used all over the world for treating various health disorders. It is employed either alone or in combination with synthetic drugs or plants to be more effective. OBJECTIVE: The assessment of the effect of both water and methanol extracts of 57 widely used plants from Traditional Chinese Medicine (TCM) against the main phase I metabolizing enzyme CYP3A4 in vitro for the first time. MATERIALS AND METHODS: The inhibition of cytochrome P450 activity was evaluated using a luminescence assay...
April 2017: Pharmacognosy Magazine
Benjamin Farahnik, Divya Sharma, Joseph Alban, Raja K Sivamani
BACKGROUND: Patients with psoriasis often enquire about the use of numerous botanical therapeutics. It is important for dermatologists to be aware of the current evidence regarding these agents. METHODS: We conducted a systematic literature search using the PubMed, MEDLINE, and EMBASE databases for controlled and uncontrolled clinical trials that assessed the use of topical botanical therapeutics for psoriasis. The search included the following keywords: 'psoriasis' and 'plant' or 'herbal' or 'botanical'...
August 2017: American Journal of Clinical Dermatology
Kun Wang, Liwei Chai, Xinchi Feng, Zhongbo Liu, Hongxia Liu, Liqin Ding, Feng Qiu
Berberine (BBR), the principle component for many medicinal plants such as Coptis chinensis Franch., Phellodendron chinense Schneid., and Mahonia bealei (Fort.) Carr., possesses diverse pharmacological activities, including anti-bacterial, anti-inflammatory, antitumor, hypolipidemic and antidiabetic activities. In this study, a rapid and reliable method using a five-step strategy based on the ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF-MS), and metabolynx™ software with mass defect filter (MDF) technique was developed to investigate the metabolism of BBR...
May 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
Dorothea Kaufmann, Anudeep Kaur Dogra, Ahmad Tahrani, Florian Herrmann, Michael Wink
Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's Disease (AD). In this study, methanol, dichloromethane and aqueous crude extracts from 80 Traditional Chinese Medical (TCM) plants were tested for their in vitro anti-acetylcholinesterase activity based on Ellman's colorimetric assay. All three extracts of Berberis bealei (formerly Mahonia bealei), Coptis chinensis and Phellodendron chinense, which contain numerous isoquinoline alkaloids, substantially inhibited AChE...
August 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Lidong Wang, Xinxin Ci, Hongming Lv, Xiaosong Wang, F Xiaofeng Qin, Genhong Cheng
1R, 1'S-isotetrandrine, a naturally occurring plant alkaloid found in Mahonia of Berberidaceae, possesses anti-inflammatory, antibacterial, and antiviral properties, but the antioxidative activity and mechanism action remain unclear. In this study, we demonstrated the antioxidative effect and mechanism of 1R, 1'S-isotetrandrine against tert-butyl hydroperoxide-induced oxidative damage in HepG2 cells. We found that 1R, 1'S-isotetrandrine suppressed cytotoxicity, reactive oxygen species generation, and glutathione depletion...
August 2016: Experimental Biology and Medicine
Wei-Kun Ma, Hui Li, Cui-Lan Dong, Xin He, Chang-Run Guo, Chun-Feng Zhang, Chun-Hao Yu, Chong-Zhi Wang, Chun-Su Yuan
Mahonia bealei is a Chinese folk medicine used to treat various ailments, in particular gastrointestinal inflammation‑related illnesses, and palmatine is one of its active constituents. In this study, ApcMin/+ mice, a genetically engineered model, were used to investigate the effects of palmatine on the initiation and progression of gut inflammation and tumorigenesis enhanced by a high‑fat diet. The in vitro antiproliferation and anti‑inflammation effects of palmatine were evaluated on HT‑29 and SW‑480 human colorectal cancer cell lines...
July 2016: Molecular Medicine Reports
Weicheng Hu, Lei Wu, Qian Qiang, Lilian Ji, Xinfeng Wang, Haiqing Luo, Haifeng Wu, Yunyao Jiang, Gongcheng Wang, Ting Shen
ETHNOPHARMACOLOGICAL RELEVANCE: Mahonia bealei has a long history of medical use in traditional Chinese medicine for the treatment of inflammatory-associated diseases. Despite numerous phytochemical and pharmacological studies, there is a lack of systematic studies to understand the cellular and molecular mechanisms of the anti-inflammatory activity of this plant. AIM OF STUDY: This study aimed to evaluate the anti-inflammatory activity of the dichloromethane fraction from M...
July 21, 2016: Journal of Ethnopharmacology
Meiyan Sun, Jie Wang, Yue Zhou, Zijian Wang, Yong Jiang, Miao Li
OBJECTIVE: Neuromyelitis optica (NMO) is a severe neurological demyelinating autoimmune disease that affects the optic nerves and spinal cord with no cure and no FDA-approved therapy. Research over the last decade revealed that the binding of NMO-IgG to the water channel protein astrocyte aquaporin 4 (AQP4) might be the primary cause of NMO pathogenesis. The purpose of this study was to identify potential blockers of NMO-IgG and AQP4 binding. METHODS: We developed a two-step screening platform consisting of a reporter cell-based high-throughput screen assay and a cell viability-based assay...
2016: Neuroimmunomodulation
Yanxia Sun, Michael J Moore, Shoujun Zhang, Pamela S Soltis, Douglas E Soltis, Tingting Zhao, Aiping Meng, Xiaodong Li, Jianqiang Li, Hengchang Wang
The grade of early-diverging eudicots includes five major lineages: Ranunculales, Trochodendrales, Buxales, Proteales and Sabiaceae. To examine the evolution of plastome structure in early-diverging eudicots, we determined the complete plastome sequences of eight previously unsequenced early-diverging eudicot taxa, Pachysandra terminalis (Buxaceae), Meliosma aff. cuneifolia (Sabiaceae), Sabia yunnanensis (Sabiaceae), Epimedium sagittatum (Berberidaceae), Euptelea pleiosperma (Eupteleaceae), Akebia trifoliata (Lardizabalaceae), Stephania japonica (Menispermaceae) and Papaver somniferum (Papaveraceae), and compared them to previously published plastomes of the early-diverging eudicots Buxus, Tetracentron, Trochodendron, Nelumbo, Platanus, Nandina, Megaleranthis, Ranunculus, Mahonia and Macadamia...
March 2016: Molecular Phylogenetics and Evolution
Jian Huang, Tao Su, Julie Lebereton-Anberrée, Shi-Tao Zhang, Zhe-Kun Zhou
Interpretation of the biogeography of the genus Mahonia (Berberidaceae) is limited by the lack of fossil records in East Asia. Compressed fossil foliage, described here as Mahonia mioasiatica sp. nov., were collected from the Upper Miocene Xiaolongtan Formation in Wenshan, Yunnan, southwest China. These specimens represent the oldest reliable fossil record of Mahonia in East Asia. This new fossil species shows a general similarity to Group Orientales and is most similar to the extant eastern Asian Mahonia conferta...
March 2016: Journal of Plant Research
T P Wyka, P Karolewski, R Żytkowiak, P Chmielarz, J Oleksyn
In evergreen plants, old leaves may contribute photosynthate to initiation of shoot growth in the spring. They might also function as storage sites for carbohydrates and nitrogen (N). We hence hypothesized that whole-plant allocation of carbohydrates and N to storage in stems and roots may be lower in evergreen than in deciduous species. We selected three species pairs consisting of an evergreen and a related deciduous species: Mahonia aquifolium (Pursh) Nutt. and Berberis vulgaris L. (Berberidaceae), Prunus laurocerasus L...
May 2016: Tree Physiology
Jian-Ming He, Qing Mu
ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the genus Mahonia Nuttall (Berberidaceae) have a long history of medical use in Traditional Chinese Medicine (TCM) for the treatment of a wide range of health disorders, such as tuberculosis, periodontitis, dysentery, pharyngolaryngitis, eczema, and wounds. In the theory of TCM, most Mahonia species exert the effects of relieving internal heat, eliminating dampness, removing toxins, suppressing pain, promoting blood circulation, inhibiting cough and alleviating inflammation...
December 4, 2015: Journal of Ethnopharmacology
Wenguang Wang, Xiaoli Ma, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang
In order to solve the bottleneck of reference standards shortage for comprehensive quality control of traditional Chinese medicines (TCMs), a series of strategies, including one single reference standard to determine multi-compounds (SSDMC), quantitative analysis by standardized reference extract (QASRE), and quantitative nuclear magnetic resonance spectroscopy (qNMR) were proposed, and Mahoniae Caulis was selected as an example to develop and validate these methods for simultaneous determination of four alkaloids, columbamine, jatrorrhizine, palmatine, and berberine...
September 18, 2015: Journal of Chromatography. A
Gang Li, Souvik Kusari, Parijat Kusari, Oliver Kayser, Michael Spiteller
A new lanostanoid, 19-nor-lanosta-5(10),6,8,24-tetraene-1α,3β,12β,22S-tetraol (1), characterized by the presence of an aromatic B ring and hydroxylated at C-1, C-3, C-12, and C-22, was isolated from an endophytic fungus, Diaporthe sp. LG23, inhabiting leaves of the Chinese medicinal plant Mahonia fortunei. Six biosynthetically related known steroids were also isolated in parallel. Their structures were confirmed on the basis of detailed spectroscopic analysis in conjunction with the published data. Compound 1, an unusual fungus-derived 19-nor-lanostane tetracyclic triterpenoid with an aromatic B-ring system, exhibited pronounced antibacterial efficacy against both Gram-positive and -negative bacteria, especially the clinical isolates of Streptococcus pyogenes and Pseudomonas aeruginosa as well as a human pathogenic strain of Staphylococcus aureus...
August 28, 2015: Journal of Natural Products
Wei Zhu, Jin Hu, Xin Wang, Jingkui Tian, Setsuko Komatsu
Mahonia is an important medicinal plant used for the treatment of human diseases. To explore the molecular mechanisms underlying the different pharmacological functions of Mahonia, organ-specific proteomics was performed. Protein profiles of leaves, stems, and roots from 2-year-old Mahonia plants were determined using gel-free/label-free proteomic technique, and totals of 304, 314, and 182 proteins were identified, respectively, and included 36 common proteins. In leaves, the most abundant proteins related to photosynthesis...
June 5, 2015: Journal of Proteome Research
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