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https://www.readbyqxmd.com/read/27902864/in-vitro-and-in-vivo-metabolic-activation-of-berbamine-to-quinone-methide-intermediate
#1
Yao Sun, Tong Yao, Hui Li, Ying Peng, Jiang Zheng
Berbamine (BBM) is a bisbenzylisoquinoline alkaloid isolated from herbal medicine Berberis amurensis. BBM has been widely used for the treatment of leukemia. Recent studies demonstrated that exposure to BBM can give rise to cytotoxicity. The major objective of this study was to explore the metabolic activation of BBM in vitro and in vivo. Two oxidative metabolites (M1 and M2) and an N-acetylcysteine (NAC) conjugate (M3) were detected in human liver microsomal incubations of BBM supplemented with NAC, and the formation of all metabolites was NADPH dependent...
November 30, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27888048/breaking-the-resistance-of-escherichia-coli-antimicrobial-activity-of-berberis-lycium-royle
#2
Tauseef Ahmad Malik, Azra N Kamili, M Z Chishti, Shazia Ahad, Mudasir A Tantry, P R Hussain, R K Johri
The antimicrobial activity of root bark of Berberis lycium and its principal component berberine was tested against a panel of microbial strains using agar well diffusion test and further analyzed using micro-broth dilution method. Preliminary analysis, on the basis of zone of Inhibition (ZOI) showed that the methanolic extract of B. lycium was highly effective against Escherichia coli (ZOI 41 ± 1 mm). Among the bacterial strains E. coli was found to be most susceptible and among fungi Candida albicans was the most susceptible for berberine as well as the crude methanolic extract of the plant...
November 23, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27876206/synergistic-anti-cancer-effects-of-galangin-and-berberine-through-apoptosis-induction-and-proliferation-inhibition-in-oesophageal-carcinoma-cells
#3
Kewei Ren, Wenzhe Zhang, Gang Wu, Jianzhuang Ren, Huibin Lu, Zongming Li, Xinwei Han
Galangin is an active pharmacological ingredient from propolis and Alpinia officinarum Hance, and has been reported to have anti-cancer and antioxidative properties. Berberine, a major component of Berberis vulgaris extract, exhibits potent anti-cancer activities through distinct molecular mechanisms. However, the anticancer effect of galangin in combination with berberine is still unknown. In the present study, we demonstrated that the combination of galangin with berberine synergistically resulted in cell growth inhibition, apoptosis and cell cycle arrest at G2/M phase with the increased intracellular reactive oxygen species (ROS) levels in oesophageal carcinoma cells...
November 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27861216/in-response
#4
Antoine Berberi, Nabih Nader
No abstract text is available yet for this article.
December 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27853905/an-antidiabetic-polyherbal-phytomedicine-confers-stress-resistance-and-extends-lifespan-in-caenorhabditis-elegans
#5
Laxmi Rathor, Aakanksha Pant, Harshika Awasthi, Dayanandan Mani, Rakesh Pandey
An Ayurvedic polyherbal extract (PHE) comprising six herbs viz. Berberis aristata, Cyperus rotundus, Cedrus deodara, Emblica officinalis, Terminalia chebula and Terminalia bellirica is mentioned as an effective anti-hyperglycemic agent in 'Charaka Samhita', the classical text of Ayurveda. Previously, antidiabetic drug metformin was found to elicit antiaging effects and PHE was also found to exhibit antidiabetic effects in humans. Therefore, we screened it for its in vivo antioxidant antiaging effect on stress and lifespan using human homologous Caenorhabditis elegans model system...
November 16, 2016: Biogerontology
https://www.readbyqxmd.com/read/27794507/-a-novel-survey-of-the-ethno-medicinal-knowledge-of-dental-problems-in-manoor-valley-northern-himalaya-pakistan
#6
Inayat Ur Rahman, Farhana Ijaz, Zafar Iqbal, Aftab Afzal, Niaz Ali, Muhammad Afzal, Muhammad Azhar Khan, Said Muhammad, Ghulam Qadir, Muhammad Asif
ETHNOPHARMACOLOGICAL RELEVANCE: In the study area, the traditional knowledge and cultural practices of utilizing medicinal plants in the human healthcare is primarily restricted to the old age members of the community, while younger generation is mostly unaware of the natural wealth usage. AIM OF THE STUDY: We provide the first ever ethno medicinal insights into the management of dental disorders in Pakistan. The prime objective of the study was to explore novel knowledge of these local and remote community members and share it with rest of the world in documented form...
October 26, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27788592/two-new-prenylated-flavonoids-from-the-roots-of-berberis-thunbergii-dc
#7
Nusrat Hussain, Achyut Adhikari, Malik Shoaib Ahmad, Atia-Tul- Wahab, Meher Ali, M Iqbal Choudhary
Two new prenylated flavonoids, thunbergiols A (1) and B (2), along with three known compounds, chrysin (3), quercetin (4) and berberine (5) were obtained from the methanolic extract of roots of Berberis thunbergii DC. MS, NMR and other spectroscopic techniques were employed for their structural characterisation.
October 27, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27762098/paralogs-are-revealed-by-proportion-of-heterozygotes-and-deviations-in-read-ratios-in-genotyping-by-sequencing-data-from-natural-populations
#8
Garrett J McKinney, Ryan K Waples, Lisa W Seeb, James E Seeb
Whole-genome duplications have occurred in the recent ancestors of many plants, fish, and amphibians, resulting in a pervasiveness of paralogous loci and the potential for both disomic and tetrasomic inheritance in the same genome. Paralogs can be difficult to reliably genotype and are often excluded from genotyping-by-sequencing (GBS) analyses; however, removal requires paralogs to be identified which is difficult without a reference genome. We present a method for identifying paralogs in natural populations by combining two properties of duplicated loci: (i) the expected frequency of heterozygotes exceeds that for singleton loci, and (ii) within heterozygotes, observed read ratios for each allele in GBS data will deviate from the 1:1 expected for singleton (diploid) loci...
October 19, 2016: Molecular Ecology Resources
https://www.readbyqxmd.com/read/27757195/comparison-between-the-efficacy-of-metronidazole-vaginal-gel-and-berberis-vulgaris-berberis-vulgaris-combined-with-metronidazole-gel-alone-in-the-treatment-of-bacterial-vaginosis
#9
Mansoure Masoudi, Mahmoud Rafieian Kopaei, Sepideh Miraj
BACKGROUND: Bacterial vaginosis is one of the most prevalent complications among reproductive-aged women. Antibacterial and antifungal effects of Berberis vulgaris have been demonstrated in vitro and in vivo. OBJECTIVES: This study aimed to compare the therapeutic effects of the vaginal gel of Berberis vulgaris 5% (in metronidazole base) with metronidazole vaginal gel 0.75% on bacterial vaginosis on 80 patients referred to the Hajar Hospital from January 2012 to April 2013...
August 2016: Electronic Physician
https://www.readbyqxmd.com/read/27750103/pharmacokinetics-excretion-of-8-cetylberberine-and-its-main-metabolites-in-rat-urine
#10
Yuli Hu, Shoujun Fan, Xiaobing Liao, Chao Chen, Liang Su, Xuegang Li
Berberine (BBR) is a bioactive plant ingredient derived from the roots and bark of Berberis aristata and Coptis chinensis and has a wide variety of pharmacological effects. 8-cetylberberine (8-BBR-C16) is the berberine (BBR) derivative reconstructed from adding octadecyl at C-8 of BBR to enhance its activity. This study presents a reliable method for the determination of BBR and 8-BBR-C16 in rat plasma, urine and feces. BBR and 8-BBR-C16 were determined by HPLC-UV after liquid-liquid extraction for plasma samples, and solid-phase extraction for urinary and fecal samples...
October 14, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27697643/berberine-and-inflammatory-bowel-disease-a-concise-review
#11
Solomon Habtemariam
Berberine is the principal component of many popular medicinal plants (e.g. the genus Berberis, Coptis and Hydrastis among others) with a history of thousands of years of usage in traditional medicine. The numerous pharmacological activities of berberine reported in the last two decades have been attracting high level interests both within the scientific community, clinicians and the public at large. Despite enormous amount of efforts have been placed to show its therapeutic value for inflammatory bowel diseases (IBD), however, comprehensive up-to-date review article in this field is not yet available...
September 30, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27689107/an-ethnobotanical-study-of-medicinal-plants-administered-for-the-treatment-of-hypertension
#12
Babak Baharvand-Ahmadi, Mahmoud Bahmani, Pegah Tajeddini, Mahmoud Rafieian-Kopaei, Nasrollah Naghdi
INTRODUCTION: The incidence of cardiovascular diseases (CVDs) is very high in human societies and their prevention and treatment are the most important priority in many countries. Hypertension makes an important contribution to the development of CVDs. OBJECTIVES: This study aimed to collect the ethno-medicinal knowledge of the traditional healers of Shiraz on medicinal plants used in the treatment of hypertension. MATERIALS AND METHODS: Ethno-medicinal data were collected from September 2012 to July 2013 through direct interview...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27671811/berberine-and-its-role-in-chronic-disease
#13
Arrigo F G Cicero, Alessandra Baggioni
Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. It is found in such plants as Berberis [e.g. Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), Berberis aristata (tree turmeric)], Hydrastis canadensis (goldenseal), Xanthorhiza simplicissima (yellowroot), Phellodendron amurense ([2]) (Amur corktree), Coptis chinensis (Chinese goldthread), Tinospora cordifolia, Argemone mexicana (prickly poppy) and Eschscholzia californica (Californian poppy). In vitro it exerts significant anti-inflammatory and antioxidant activities...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27660088/antibacterial-in-vitro-effects-of-preparations-from-anthroposophical-medicine
#14
Eva Roser, Carsten Gründemann, Inge Engels, Roman Huber
BACKGROUND: Medications from Anthroposophical Medicine (AM) are clinically used for the treatment of infections within a whole medical system but have not yet been evaluated regarding antibacterial effects. The aims of this study was to investigate antibacterial activity of AM medications in cell culture. METHODS: Screening of AM drug registers for preparations used to treat any kind of infection and being available in dilutions ≤ D2 and without alcoholic content...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27589716/extracts-from-traditional-chinese-medicinal-plants-inhibit-acetylcholinesterase-a-known-alzheimer-s-disease-target
#15
Dorothea Kaufmann, Anudeep Kaur Dogra, Ahmad Tahrani, Florian Herrmann, Michael Wink
Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's Disease (AD). In this study, methanol, dichloromethane and aqueous crude extracts from 80 Traditional Chinese Medical (TCM) plants were tested for their in vitro anti-acetylcholinesterase activity based on Ellman's colorimetric assay. All three extracts of Berberis bealei (formerly Mahonia bealei), Coptis chinensis and Phellodendron chinense, which contain numerous isoquinoline alkaloids, substantially inhibited AChE...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27585588/mesenchymal-stem-cells-with-osteogenic-potential-in-human-maxillary-sinus-membrane-an-in-vitro-study
#16
Antoine Berbéri, Fatima Al-Nemer, Eva Hamade, Ziad Noujeim, Bassam Badran, Kazem Zibara
OBJECTIVES: The aim of our study is to prove and validate the existence of an osteogenic progenitor cell population within the human maxillary Schneiderian sinus membrane (hMSSM) and to demonstrate their potential for bone formation. MATERIALS AND METHODS: Ten hMSSM samples of approximately 2 × 2 cm were obtained during a surgical nasal approach for treatment of chronic rhinosinusitis and were retained for this study. The derived cells were isolated, cultured, and assayed at passage 3 for their osteogenic potential using the expression of Alkaline phosphatase, alizarin red and Von Kossa staining, flow cytometry, and quantitative real-time polymerase chain reaction...
September 1, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27583213/evaluation-of-the-oral-component-of-sj%C3%A3-gren-s-syndrome-an-overview
#17
REVIEW
Georges Aoun, Ibrahim Nasseh, Antoine Berberi
Sjögren's syndrome is a chronic autoimmune disorder characterized by lymphocytic infiltration, and consequently hypofunction of lacrimal and salivary glands. The loss of salivary function induces oral dryness (xerostomia). This review focuses on methods for determining salivary gland function including clinical signs, salivary flow rate measurements (sialometry), analysis of salivary composition (sialochemistry), histopathological and radiologic examinations, and other recent advanced techniques.
July 2016: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/27577059/investigation-of-the-immunomodulatory-effect-of-berberis-vulgaris-on-core-pulsed-dendritic-cell-vaccine
#18
Doaa A Ghareeb, Eiman H Elwakeel, Rowaida Khalil, Mina S Aziz, Maha A El Demellawy
BACKGROUND: Virus-induced dendritic cells (DCs) functional deficiency leads to sub-optimal initiation of adaptive immune responses and consequently chronic infection establishment. The present study reports an advanced hepatitis C virus (HCV) therapeutic vaccine model based on In vivo enrichment of DCs with barberry ethanolic crude extract (BCE) then pulsing them with HCV core protein. METHODS: DCs were enriched by BCE intravenous injection in BALB/c mice. Vaccine efficiency was assessed by flow cytometric analysis of splenocytes of immunized mice, cytokine profiling, cytotoxic T lymphocyte assay, and humoral immune response assessment...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27542453/nutraceutical-potential-of-selected-wild-edible-fruits-of-the-indian-himalayan-region
#19
Indra D Bhatt, Sandeep Rawat, Amit Badhani, Ranbeer S Rawal
Wild edible fruits contribute significantly to the nutritional security of mankind across the globe. However, detailed analyses of health promoting bioactive compounds and antioxidants are lacking, especially in Himalayan wild edible fruits. Bioactive compounds and antioxidant potential of 10 wild edible fruits reveal that Terminalia chebula, Phyllanthus emblica and Myrica esculenta are the richest source of total phenolics; Pyaracantha crenulata, Terminalia chebula and Berberis asiatica for flavonoids; Phyllanthus emblica, Morus alba and Ficus palmata for ascorbic acid, anthocyanins, and Morus alba for β-carotene...
January 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27530832/augmenting-the-potency-of-third-line-antibiotics-with-berberis-aristata-in-vitro-synergistic-activity-against-carbapenem-resistant-escherichia-coli
#20
Pallavi Thakur, Raman Chawla, Rajeev Goel, Alka Narula, Rajesh Arora, Rakesh Kumar Sharma
The aim of this study was to analyse the in vitro synergistic antibacterial potential of an aquoethanolic extract of the stem bark of Berberis aristata (PTRC-2111-A) with third-line antibiotics against carbapenem-resistant Escherichia coli. PTRC-2111-A was prepared and was characterised using phytochemical- and bioactivity-based fingerprinting. Fourier transform infrared spectroscopy (FTIR) and liquid chromatography-mass spectrometry (LC-MS) analyses were performed, and superoxide and hydroxyl scavenging activities were assessed in conjunction with in vitro antimicrobial efficacy testing against the test micro-organism...
September 2016: Journal of Global Antimicrobial Resistance
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