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https://www.readbyqxmd.com/read/29740574/two-step-thermochemical-cellulose-hydrolysis-with-partial-neutralization-for-glucose-production
#1
James Kong-Win Chang, Xavier Duret, Véronique Berberi, Hassan Zahedi-Niaki, Jean-Michel Lavoie
Cellulose hydrolysis processes using concentrated acid usually involve two steps in order to obtain high glucose yields. The first step (pre-treatment) decrystallizes cellulose while the second step (post-hydrolysis) converts the amorphous cellulose to glucose. The two-step process developed by the Industrial Research Chair on Cellulosic Ethanol and Biocommodities and its industrial partner CRB Innovations Inc., includes an intermediate partial neutralization step, whose purpose is to decrease the amount of dilution water to be added for post-hydrolysis thus minimizing handling costs...
2018: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29701777/berbamine-suppresses-cell-proliferation-and-promotes-apoptosis-in-ovarian-cancer-partially-via-the-inhibition-of-wnt-%C3%AE-catenin-signaling
#2
Heng Zhang, Yunping Jiao, Chunyang Shi, Xiao Song, Ying Chang, Yong Ren, Xiaolin Shi
Ovarian cancer is a common and lethal cancer affecting women globally. Berbamine is a natural compound from the plant Berberis amurensis, which is used in Chinese traditional medicine. Recent studies have shown the anti-tumor effects of berbamine in several types of cancers but not in ovarian cancer. In the present study, we investigated the potential anti-tumor effects of berbamine in ovarian cancer and explored the underlying molecular mechanisms. Berbamine suppressed the cell viability of ovarian cancer cells in a concentration-dependent manner as revealed by methyl thiazolyl tetrazolium assay...
April 26, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29677540/ameliorating-effect-of-berbamine-on-hepatic-key-enzymes-of-carbohydrate-metabolism-in-high-fat-diet-and-streptozotocin-induced-type-2-diabetic-rats
#3
Sankaranarayanan Chandrasekaran, Nishanthi Ramajayam, Pugalendi Pachaiappan
BACKGROUND: Aberrations in the activities of key enzymes of carbohydrate metabolism is well documented in diabetes mellitus. Previous studies have shown that active ingredients in the extracts of Berberis aristata exhibits diverse pharmacological activities in animal models. OBJECTIVE: The present study was undertaken to investigate whether berbamine (BBM), an alkaloid from the roots of Berberis aristata can ameliorate the altered activities of carbohydrate metabolic enzymes in high fat diet (HFD)/streptozotocin (STZ) induced diabetic rats...
April 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29611656/the-effect-of-acetylosalicylic-acid-and-berberis-on-ascites-syndrome-parameters-in-broiler-chickens
#4
M Hormozi, M Jahantigh, M Jahantigh
One-hundred and thirty day-old broiler chickens were kept for 6 days and on the seventh day, 120 chickens were selected and randomly divided into 5 groups with 2 replicates. To cause ascites, an amount of 0.12% sodium was added to the drinking water of 4 groups of chickens. On the fourteenth day, the amount of sodium was increased to 0.24% and at the same time, treatment with acetylosalicylic acid and berberis was started. At the age of 14 and 21 days, random sample chickens from each replicate were necropsied and were examined in terms of the factors associated with ascites...
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29606969/bioassay-directed-isolation-of-quaternary-benzylisoquinolines-from-berberis-integerrima-with-bactericidal-activity-against-brucella-abortus
#5
Gholamhassan Azimi, Ali Hakakian, Mustafa Ghanadian, Ali Joumaa, Saeed Alamian
Berberis integerrima Bonge. (Syn: Berberis densiflora Boiss. & Buhse) is a shrub widely distributed in Middle East and central part of Asia. An ethnobotanical study revealed that indigenous and tribal people in Iran use B. integerrima root decoction for treatment of brucellosis. Therefore, the aim of this study was bioassay directed isolation of antibacterial compounds from this plant based on their in vitro bactericidal activity against Brucella abortus . Briefly, the ethanol extract of B. integerrima was fractioned and subjected to preliminary antibacterial screening tests against Brucella...
April 2018: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29571723/phytochemical-profiling-and-antiviral-activity-of-ajuga-bracteosa-ajuga-parviflora-berberis-lycium-and-citrus-lemon-against-hepatitis-c-virus
#6
Tahir Yousaf, Shazia Rafique, Fazli Wahid, Sidra Rehman, Abdul Nazir, Javeria Rafique, Kashif Aslam, Ghulam Shabir, Shahid Masood Shah
Hepatitis C is a serious health issue and cause liver disorders in millions of people. Available therapeutic agents require long term administration with numerous side effects. Therefore, there is a dire need to find alternative treatment options for this disease. Since ancient times, medicinal plants are widely used to cure various diseases with no or less harmful effects. Therefore, this study was designed to find out phytochemicals and investigate antiviral activity of methanol extract of Ajuga bracteosa, Ajuga parviflora, Berberis lycium and Citrus lemon against Hepatitis C Virus (HCV infection)...
March 20, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29566404/in-vitro-effects-of-homeopathic-drugs-on-cultured-escherichia-coli
#7
Jürgen Pannek, Carmen Kurmann, Esther Imbach, Felix Amsler, Susanne Pannek-Rademacher
BACKGROUND:  Recurrent urinary tract infections (UTIs) are one of the most common morbidities in persons with neurogenic lower urinary tract dysfunction (NLUTD). Repetitive antibiotic treatment increases the risk of selecting multi-resistant bacteria. Homeopathic treatment has been reported to be effective in these patients. The mechanism of action, however, has not been clarified. Recently, a direct bactericidal effect of homeopathic remedies was shown. Such an effect is not in accordance with the general principles of homeopathy...
March 22, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29529250/an-interspecific-barberry-hybrid-enables-genetic-dissection-of-non-host-resistance-to-the-stem-rust-pathogen-puccinia-graminis
#8
Radhika Bartaula, Arthur T O Melo, Bryan A Connolly, Yue Jin, Iago Hale
Stem rust, caused by Puccinia graminis (Pg), remains a devastating disease of wheat, and the emergence of new Pg races virulent on deployed resistance genes fuels the ongoing search for sources of durable resistance. Despite its intrinsic durability, non-host resistance (NHR) is largely unexplored as a protection strategy against Pg, partly due to the inherent challenge of developing a genetically tractable system within which NHR segregates. Here, we demonstrate that Pg's far less studied ancestral host, barberry (Berberis spp...
April 27, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29515798/metformin-and-berberine-two-versatile-drugs-in-treatment-of-common-metabolic-diseases
#9
REVIEW
Haoran Wang, Chen Zhu, Ying Ying, Lingyu Luo, Deqiang Huang, Zhijun Luo
Metformin has been used as a glucose lowering drug for several centuries and is now a first-line drug for type 2 diabetes mellitus (T2DM). Since the discovery that it activates AMP-activated protein kinase (AMPK) and reduces risk of cancer, metformin has drawn great attentions. Another drug, berberine, extracted from berberis vulgaris L. (root), was an ancient herbal medicine in treating diarrhea. Ongoing experimental and clinical studies have illuminated great potential of berberine in regulation of glucose and lipid homeostasis, cancer growth and inflammation...
February 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29492175/impact-of-cone-beam-computed-tomography-dose-in-pre-surgical-implant-analysis
#10
Nabil El Sahili, Ibrahim Nasseh, Antoine Berberi, Sandra David-Tchouda, Sophie Thoret, Thomas Fortin
Objectives: Cone-Beam Computed Tomography (CBCT) produces vital information required for the accurate and prudent placement of dental implants. Lack of standardization between CBCT machines may result in unsafe patient exposure to harmful radiation; higher doses are not necessarily associated with improved image quality. Aim: The study aimed to assess the influence of low- and high-dose milliamperage settings on CBCT images for objective and subjective implant planning...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29472940/inheritance-and-linkage-of-virulence-genes-in-chinese-predominant-race-cyr32-of-the-wheat-stripe-rust-pathogen-puccinia-striiformis-f-sp-tritici
#11
Long Wang, Dan Zheng, Shuxia Zuo, Xianming Chen, Hua Zhuang, Lili Huang, Zhensheng Kang, Jie Zhao
Puccinia striiformis f.sp. tritici ( Pst ) is the causal agent of stripe (yellow) rust on wheat. It seriously threatens wheat production worldwide. The obligate biotrophic fungus is highly capable of producing new virulent races that can overcome resistance. Studying the inheritance of Pst virulence using the classical genetic approach was not possible until the recent discovery of its sexual stage on barberry plants. In the present study, 127 progeny isolates were obtained by selfing a representative Chinese Yellow Rust (CYR) race, CYR32, on Berberis aggregate ...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29447950/ethnobotanical-and-ethnomedicinal-studies-in-baluchi-tribes-a-case-study-in-mt-taftan-southeastern-iran
#12
Tahereh Maleki, Hossein Akhani
ETHNOBOTANICAL RELEVANCE: From ancient times, the applied use of herbs has been common among indigenous people throughout the world. The present survey is a regional ethnobotanical study of Baluchi tribes living in the Mt. Taftan area, Sistan and Baluchistan Province, southeastern Iran. The aim of this study was to document all traditional knowledge and analyze the medicinal plants used in area and also to identify significant plant species for future pharmacological study. MATERIALS AND METHODS: Local knowledge was obtained through semi structured and open interviews, in which 51 informants were interviewed...
May 10, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29411090/combined-analytical-approaches-to-define-biodistribution-and-biological-activity-of-semi-synthetic-berberrubine-the-active-metabolite-of-natural-berberine
#13
Emanuele Porru, Placido Franco, Donato Calabria, Silvia Spinozzi, Marinella Roberti, Cristiana Caliceti, Aldo Roda
Berberine (BBR) is a natural alkaloid obtained from Berberis species plants, known for its protective effects against several diseases. Among the primary BBR metabolites, berberrubine (M1) showed the highest plasma concentration but few and conflicting data are available regarding its concentration in biological fluids related to its new potential activity on vascular cells. A combined analytical approach was applied to study biodistribution of M1 in comparison with BBR. The optimization of sample clean-up combined with a fully validated HPLC-ESI-MS/MS tailored for M1 allows sufficient detectability and accuracy to be reached in the different studied organs even when administered at low dose, comparable to that assumed by human...
February 7, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29393562/a-novel-mads-box-transcription-factor-pstmcm1-1-is-responsible-for-full-virulence-of-puccinia-striiformis-f-sp-tritici
#14
Xiaoguo Zhu, Min Jiao, Jia Guo, Peng Liu, Chenglong Tan, Qian Yang, Yang Zhang, Ralf Thomas Voegele, Zhensheng Kang, Jun Guo
In many eukaryotes, transcription factor MCM1 gene plays crucial roles in regulating mating processes and pathogenesis by interacting with other co-factors. However, little is known about the role of MCM1 in rust fungi. Here, we identified two MCM1 orthologs, PstMCM1-1 and PstMCM1-2, in the stripe rust pathogen Puccinia striiformis f. sp. tritici (Pst). Sequence analysis indicated that both PstMCM1-1 and PstMCM1-2 contain conserved MADS domains and that PstMCM1-1 belongs to a group of SRF-like proteins that are evolutionarily specific to rust fungi...
April 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29372037/neuroprotective-effect-of-berberine-chloride-on-cognitive-impairment-and-hippocampal-damage-in-experimental-model-of-vascular-dementia
#15
Mahila Lotfi Aski, Mohammad Ebrahim Rezvani, Mehdi Khaksari, Zeynab Hafizi, Zeynab Pirmoradi, Somayeh Niknazar, Fatemeh Zare Mehrjerdi
Objectives: The major objective of the present study was to investigate the potential neuroprotective effect of berberine chloride on vascular dementia. Berberine, as an ancient medicine in China and India, is the main active component derived from the Berberis sp . Several studies have revealed the beneficial effects of berberine in various neurodegenerative disorders. Materials and Methods: To induce vascular dementia, chronic bilateral common carotid artery occlusion was performed on male Wistar rats...
January 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29350661/retrospective-analysis-of-the-effects-of-a-highly-standardized-mixture-of-berberis-aristata-silybum-marianum-and-monacolins-k-and-ka-in-diabetic-patients-with-dyslipidemia
#16
Francesco Di Pierro, Pietro Putignano, Nicola Villanova
BACKGROUND: Berberine, an alkaloid with both glucose- and cholesterol-lowering action, is also characterized by an anti-diarrheal effect. Consequently, berberine-based therapies are recommended for diabetic patients with irritable bowel syndrome (IBS) or gut discomfort caused by metformin. AIM: As the anti-glycemic and cholesterol-lowering action of berberine is improved by co-administration with P-glycoprotein inhibitors and naturally derived statins, we have analyzed the effect of the food supplement Berberol®K (hereafter referred to as BSM) containing, berberine, silymarin, and a highly standardized red yeast rice containing monacolins K and KA in the ratio 1:1 but no secondary monacolins, dehydromonacolins, or citrinin (Monakopure™-K20)...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29335865/beneficial-effect-of-berberis-amurensis-rupr-on-penile-erection
#17
Rui Tan, Yun Jung Lee, Kyung Woo Cho, Dae Gill Kang, Ho Sub Lee
OBJECTIVE: To investigate whether the methanol extract of Berberis amurensis Rupr. (BAR) augments penile erection using in vitro and in vivo experiments. METHODS: The ex vivo study used corpus cavernosum strips prepared from adult male New Zealand White rabbits. In in vivo studies for intracavernous pressure (ICP), blood pressure, mean arterial pressure (MAP), and increase of peak ICP were continuously monitored during electrical stimulation of Sprague-Dawley rats...
January 15, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29333368/oral-lesions-associated-with-human-immunodeficiency-virus-in-75-adult-patients-a-clinical-study
#18
Antoine Berberi, Georges Aoun
Objectives: The objective of this study was to investigate the presence of oral lesions in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) patients in a descriptive cross-sectional study, and to establish their presence according to levels of CD4+ cells (including the CD4+/CD8+ cell ratio). Materials and Methods: A total of 75 patients infected with HIV were included. Oral lesions were observed and classified using World Health Organization classification guidelines...
December 2017: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://www.readbyqxmd.com/read/29333041/pharmacological-evaluation-of-hepatoprotective-activity-of-ahpl-aytab-0613-tablet-in-carbon-tetrachloride-ethanol-and-paracetamol-induced-hepatotoxicity-models-in-wistar-albino-rats
#19
Sanjay U Nipanikar, Sohan S Chitlange, Dheeraj Nagore
Background: Hepatotoxicity ultimately leads to liver failure. Conventional treatment options for hepatotoxicity are limited and not safe. Objective: Formulation AHPL/AYTAB/0613 is developed to provide safer and effective hepatoprotective drug of natural origin. A study was conducted to evaluate hepatoprotective activity of AHPL/AYTAB/0613 (three dosages) in comparison with marketed formulations in carbon tetrachloride (CCl4 ), ethanol, and paracetamol-induced hepatotoxicity in Wistar albino rats...
December 2017: Pharmacognosy Research
https://www.readbyqxmd.com/read/29284917/assessment-of-the-mental-foramen-location-in-a-sample-of-fully-dentate-lebanese-adults-using-cone-beam-computed-tomography-technology
#20
Georges Aoun, Abbass El-Outa, Nakhle Kafrouny, Antoine Berberi
Objective: The literature reports that the location of mental foramen shows differences among races. The aim of this study was to assess the mental foramen position in a sample of Lebanese population using cone-beam computed tomography (CBCT) technology. Materials and methods: In this study, we investigated CBCT images of 50 fully dentate Lebanese adults (23 males and 27 females). We assessed the horizontal position of the mental foramen in relation with the mandibular premolars in both right and left sides and the vertical position by measuring the distance from the upper border of the foramen to the inferior border of the body of the mandible...
December 2017: Acta Informatica Medica: AIM
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