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https://www.readbyqxmd.com/read/28061403/berberine-ameliorates-intrahippocampal-kainate-induced-status-epilepticus-and-consequent-epileptogenic-process-in-the-rat-underlying-mechanisms
#1
Reza Sedaghat, Yosra Taab, Zahra Kiasalari, Siamak Afshin-Majd, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Status epilepticus (SE) is a life-threatening neurologic condition, instigating epileptogenesis to transform normal brain to an epileptic condition. SE is followed by spontaneous recurrent seizures (SRS) and final development of temporal lobe epilepsy (TLE) that is resistant to treatment. Neuroprotective strategies are increasingly put forward as a promising therapy to prevent and/or manage epileptic conditions. In this study, we investigated whether berberis alkaloid, i.e. berberine (BBR), could ameliorate intrahippocampal kainate-induced SE and its consequent epileptogenic process and to explore some underlying mechanisms...
January 3, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28058034/retrospective-analysis-of-the-effects-of-a-highly-standardized-mixture-of-berberis-aristata-silybum-marianum-and-monacolins-k-and-ka-in-patients-with-dyslipidemia
#2
Francesco Di Pierro, Pietro Putignano, Tarcisio Ferrara, Carmela Raiola, Giuliana Rapacioli, Nicola Villanova
BACKGROUND: Berberis aristata, because of its berberine content, and Monascus purpureus fermented rice, because of the presence of monacolins (naturally derived statins), are widely investigated food-grade ingredients used to formulate cholesterol-lowering supplements. Although they are extensively used, berberine is poorly absorbed and monacolins are poorly chemically characterized, not standardized, and possibly contaminated with toxic compounds. Silymarin is reported to enhance berberine absorption, while Monakopure™-K20 (MK-20) is a highly standardized red yeast rice containing monacolins K and KA in the ratio of 1:1 but not secondary monacolins, dehydromonacolins, or citrinin...
2017: Clinical Pharmacology: Advances and Applications
https://www.readbyqxmd.com/read/27975677/isolation-and-determination-of-antioxidant-capacities-of-anthocyanin-from-berberis-integerrima-bunge-fruits
#3
M Moein, Z Sabahi, F Farmani
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27965499/micromovement-evaluation-of-original-and-compatible-abutments-at-the-implant-abutment-interface
#4
Antoine Berberi, Dagher Maroun, Wasfi Kanj, El Zoughbi Amine, Aramouni Philippe
INTRODUCTION: Use of compatible abutments may increase micromovements between the abutments, and the inner part of the implant may increase the stress on marginal bone level. Also micromovement will change the volume of the inner space of the implant-abutment complex. The resulting pumping effect can transport even initially immobile microorganisms from the exterior to the interior and vice versa. OBJECTIVES: The purpose of the study was to evaluate the mechanical comportment of OsseoSpeed™ Tx implants connected with original and compatible abutments in vitro under simulated clinical loading conditions...
November 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27902864/in-vitro-and-in-vivo-metabolic-activation-of-berbamine-to-quinone-methide-intermediate
#5
Yao Sun, Tong Yao, Hui Li, Ying Peng, Jiang Zheng
Berbamine (BBM) is a bisbenzylisoquinoline alkaloid isolated from herbal medicine Berberis amurensis. BBM has been widely used for the treatment of leukemia. Recent studies demonstrated that exposure to BBM can give rise to cytotoxicity. The major objective of this study was to explore the metabolic activation of BBM in vitro and in vivo. Two oxidative metabolites (M1 and M2) and an N-acetylcysteine (NAC) conjugate (M3) were detected in human liver microsomal incubations of BBM supplemented with NAC, and the formation of all metabolites was NADPH dependent...
November 30, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27888048/breaking-the-resistance-of-escherichia-coli-antimicrobial-activity-of-berberis-lycium-royle
#6
Tauseef Ahmad Malik, Azra N Kamili, M Z Chishti, Shazia Ahad, Mudasir A Tantry, P R Hussain, R K Johri
The antimicrobial activity of root bark of Berberis lycium and its principal component berberine was tested against a panel of microbial strains using agar well diffusion test and further analyzed using micro-broth dilution method. Preliminary analysis, on the basis of zone of Inhibition (ZOI) showed that the methanolic extract of B. lycium was highly effective against Escherichia coli (ZOI 41 ± 1 mm). Among the bacterial strains E. coli was found to be most susceptible and among fungi Candida albicans was the most susceptible for berberine as well as the crude methanolic extract of the plant...
January 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27876206/synergistic-anti-cancer-effects-of-galangin-and-berberine-through-apoptosis-induction-and-proliferation-inhibition-in-oesophageal-carcinoma-cells
#7
Kewei Ren, Wenzhe Zhang, Gang Wu, Jianzhuang Ren, Huibin Lu, Zongming Li, Xinwei Han
Galangin is an active pharmacological ingredient from propolis and Alpinia officinarum Hance, and has been reported to have anti-cancer and antioxidative properties. Berberine, a major component of Berberis vulgaris extract, exhibits potent anti-cancer activities through distinct molecular mechanisms. However, the anticancer effect of galangin in combination with berberine is still unknown. In the present study, we demonstrated that the combination of galangin with berberine synergistically resulted in cell growth inhibition, apoptosis and cell cycle arrest at G2/M phase with the increased intracellular reactive oxygen species (ROS) levels in oesophageal carcinoma cells...
December 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27861216/in-response
#8
Antoine Berberi, Nabih Nader
No abstract text is available yet for this article.
December 2016: Implant Dentistry
https://www.readbyqxmd.com/read/27853905/an-antidiabetic-polyherbal-phytomedicine-confers-stress-resistance-and-extends-lifespan-in-caenorhabditis-elegans
#9
Laxmi Rathor, Aakanksha Pant, Harshika Awasthi, Dayanandan Mani, Rakesh Pandey
An Ayurvedic polyherbal extract (PHE) comprising six herbs viz. Berberis aristata, Cyperus rotundus, Cedrus deodara, Emblica officinalis, Terminalia chebula and Terminalia bellirica is mentioned as an effective anti-hyperglycemic agent in 'Charaka Samhita', the classical text of Ayurveda. Previously, antidiabetic drug metformin was found to elicit antiaging effects and PHE was also found to exhibit antidiabetic effects in humans. Therefore, we screened it for its in vivo antioxidant antiaging effect on stress and lifespan using human homologous Caenorhabditis elegans model system...
November 16, 2016: Biogerontology
https://www.readbyqxmd.com/read/27794507/a-novel-survey-of-the-ethno-medicinal-knowledge-of-dental-problems-in-manoor-valley-northern-himalaya-pakistan
#10
Inayat Ur Rahman, Farhana Ijaz, Zafar Iqbal, Aftab Afzal, Niaz Ali, Muhammad Afzal, Muhammad Azhar Khan, Said Muhammad, Ghulam Qadir, Muhammad Asif
ETHNOPHARMACOLOGICAL RELEVANCE: In the study area, the traditional knowledge and cultural practices of utilizing medicinal plants in the human healthcare is primarily restricted to the old age members of the community, while younger generation is mostly unaware of the natural wealth usage. AIM OF THE STUDY: We provide the first ever ethno medicinal insights into the management of dental disorders in Pakistan. The prime objective of the study was to explore novel knowledge of these local and remote community members and share it with rest of the world in documented form...
December 24, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27788592/two-new-prenylated-flavonoids-from-the-roots-of-berberis-thunbergii-dc
#11
Nusrat Hussain, Achyut Adhikari, Malik Shoaib Ahmad, Atia-Tul- Wahab, Meher Ali, M Iqbal Choudhary
Two new prenylated flavonoids, thunbergiols A (1) and B (2), along with three known compounds, chrysin (3), quercetin (4) and berberine (5) were obtained from the methanolic extract of roots of Berberis thunbergii DC. MS, NMR and other spectroscopic techniques were employed for their structural characterisation.
April 2017: Natural Product Research
https://www.readbyqxmd.com/read/27762098/paralogs-are-revealed-by-proportion-of-heterozygotes-and-deviations-in-read-ratios-in-genotyping-by-sequencing-data-from-natural-populations
#12
Garrett J McKinney, Ryan K Waples, Lisa W Seeb, James E Seeb
Whole-genome duplications have occurred in the recent ancestors of many plants, fish, and amphibians, resulting in a pervasiveness of paralogous loci and the potential for both disomic and tetrasomic inheritance in the same genome. Paralogs can be difficult to reliably genotype and are often excluded from genotyping-by-sequencing (GBS) analyses; however, removal requires paralogs to be identified which is difficult without a reference genome. We present a method for identifying paralogs in natural populations by combining two properties of duplicated loci: (i) the expected frequency of heterozygotes exceeds that for singleton loci, and (ii) within heterozygotes, observed read ratios for each allele in GBS data will deviate from the 1:1 expected for singleton (diploid) loci...
October 19, 2016: Molecular Ecology Resources
https://www.readbyqxmd.com/read/27757195/comparison-between-the-efficacy-of-metronidazole-vaginal-gel-and-berberis-vulgaris-berberis-vulgaris-combined-with-metronidazole-gel-alone-in-the-treatment-of-bacterial-vaginosis
#13
Mansoure Masoudi, Mahmoud Rafieian Kopaei, Sepideh Miraj
BACKGROUND: Bacterial vaginosis is one of the most prevalent complications among reproductive-aged women. Antibacterial and antifungal effects of Berberis vulgaris have been demonstrated in vitro and in vivo. OBJECTIVES: This study aimed to compare the therapeutic effects of the vaginal gel of Berberis vulgaris 5% (in metronidazole base) with metronidazole vaginal gel 0.75% on bacterial vaginosis on 80 patients referred to the Hajar Hospital from January 2012 to April 2013...
August 2016: Electronic Physician
https://www.readbyqxmd.com/read/27750103/pharmacokinetics-excretion-of-8-cetylberberine-and-its-main-metabolites-in-rat-urine
#14
Yuli Hu, Shoujun Fan, Xiaobing Liao, Chao Chen, Liang Su, Xuegang Li
Berberine (BBR) is a bioactive plant ingredient derived from the roots and bark of Berberis aristata and Coptis chinensis and has a wide variety of pharmacological effects. 8-cetylberberine (8-BBR-C16) is the berberine (BBR) derivative reconstructed from adding octadecyl at C-8 of BBR to enhance its activity. This study presents a reliable method for the determination of BBR and 8-BBR-C16 in rat plasma, urine and feces. BBR and 8-BBR-C16 were determined by HPLC-UV after liquid-liquid extraction for plasma samples, and solid-phase extraction for urinary and fecal samples...
January 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27697643/berberine-and-inflammatory-bowel-disease-a-concise-review
#15
Solomon Habtemariam
Berberine is the principal component of many popular medicinal plants (e.g. the genus Berberis, Coptis and Hydrastis among others) with a history of thousands of years of usage in traditional medicine. The numerous pharmacological activities of berberine reported in the last two decades have been attracting high level interests both within the scientific community, clinicians and the public at large. Despite enormous amount of efforts have been placed to show its therapeutic value for inflammatory bowel diseases (IBD), however, comprehensive up-to-date review article in this field is not yet available...
September 30, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27689107/an-ethnobotanical-study-of-medicinal-plants-administered-for-the-treatment-of-hypertension
#16
Babak Baharvand-Ahmadi, Mahmoud Bahmani, Pegah Tajeddini, Mahmoud Rafieian-Kopaei, Nasrollah Naghdi
INTRODUCTION: The incidence of cardiovascular diseases (CVDs) is very high in human societies and their prevention and treatment are the most important priority in many countries. Hypertension makes an important contribution to the development of CVDs. OBJECTIVES: This study aimed to collect the ethno-medicinal knowledge of the traditional healers of Shiraz on medicinal plants used in the treatment of hypertension. MATERIALS AND METHODS: Ethno-medicinal data were collected from September 2012 to July 2013 through direct interview...
2016: Journal of Renal Injury Prevention
https://www.readbyqxmd.com/read/27671811/berberine-and-its-role-in-chronic-disease
#17
Arrigo F G Cicero, Alessandra Baggioni
Berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. It is found in such plants as Berberis [e.g. Berberis aquifolium (Oregon grape), Berberis vulgaris (barberry), Berberis aristata (tree turmeric)], Hydrastis canadensis (goldenseal), Xanthorhiza simplicissima (yellowroot), Phellodendron amurense ([2]) (Amur corktree), Coptis chinensis (Chinese goldthread), Tinospora cordifolia, Argemone mexicana (prickly poppy) and Eschscholzia californica (Californian poppy). In vitro it exerts significant anti-inflammatory and antioxidant activities...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27660088/antibacterial-in-vitro-effects-of-preparations-from-anthroposophical-medicine
#18
Eva Roser, Carsten Gründemann, Inge Engels, Roman Huber
BACKGROUND: Medications from Anthroposophical Medicine (AM) are clinically used for the treatment of infections within a whole medical system but have not yet been evaluated regarding antibacterial effects. The aims of this study was to investigate antibacterial activity of AM medications in cell culture. METHODS: Screening of AM drug registers for preparations used to treat any kind of infection and being available in dilutions ≤ D2 and without alcoholic content...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27589716/extracts-from-traditional-chinese-medicinal-plants-inhibit-acetylcholinesterase-a-known-alzheimer-s-disease-target
#19
Dorothea Kaufmann, Anudeep Kaur Dogra, Ahmad Tahrani, Florian Herrmann, Michael Wink
Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's Disease (AD). In this study, methanol, dichloromethane and aqueous crude extracts from 80 Traditional Chinese Medical (TCM) plants were tested for their in vitro anti-acetylcholinesterase activity based on Ellman's colorimetric assay. All three extracts of Berberis bealei (formerly Mahonia bealei), Coptis chinensis and Phellodendron chinense, which contain numerous isoquinoline alkaloids, substantially inhibited AChE...
August 31, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27585588/mesenchymal-stem-cells-with-osteogenic-potential-in-human-maxillary-sinus-membrane-an-in-vitro-study
#20
Antoine Berbéri, Fatima Al-Nemer, Eva Hamade, Ziad Noujeim, Bassam Badran, Kazem Zibara
OBJECTIVES: The aim of our study is to prove and validate the existence of an osteogenic progenitor cell population within the human maxillary Schneiderian sinus membrane (hMSSM) and to demonstrate their potential for bone formation. MATERIALS AND METHODS: Ten hMSSM samples of approximately 2 × 2 cm were obtained during a surgical nasal approach for treatment of chronic rhinosinusitis and were retained for this study. The derived cells were isolated, cultured, and assayed at passage 3 for their osteogenic potential using the expression of Alkaline phosphatase, alizarin red and Von Kossa staining, flow cytometry, and quantitative real-time polymerase chain reaction...
September 1, 2016: Clinical Oral Investigations
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