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instabil angina

Gaetano A Lanza, Gregory A Sgueglia, Giulia Angeloni, Sergio Valsecchi, Alfonso Sestito, Antonio G Rebuzzi, Filippo Crea, Attilio Maseri, Domenico Cianflone et al.
Heart rate turbulence (HRT) provided insights into cardiac autonomic function and predicted clinical outcome in patients with myocardial infarction. A relation between cardiac autonomic function and inflammation was shown in several clinical settings. To assess the prognostic impact of HRT and its relation with inflammation in patients with unstable angina pectoris (UAP), HRT parameters (turbulence onset [TO] and turbulence slope [TS]) were measured in 331 patients with UAP (age 66.4 +/- 10 years; 231 men) with premature ventricular complexes on electrocardiographic Holter monitoring...
April 15, 2009: American Journal of Cardiology
Natale Daniele Brunetti, Irene Munno, Pier Luigi Pellegrino, Vincenzo Ruggiero, Michele Correale, Andrea Cuculo, Luisa De Gennaro, Giulio Campanale, Giovanni Mavilio, Luigi Ziccardi, Matteo Di Biase
AIM: To investigate release of some inflammatory cytokines (Cys) after coronary angioplasty and its links with coronary atherosclerosis. METHODS: Twenty-seven consecutive subjects with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI) were enrolled in the study: serial blood samples were taken in order to evaluate plasma concentrations of Interleukin (IL)-2, IL-10, IL-18, TNFalpha, and IFNgamma just before PCI at 12 and 24 hours...
August 2007: Journal of Interventional Cardiology
Gaetano A Lanza, Gregory Angelo Sgueglia, Domenico Cianflone, Antonio G Rebuzzi, Giulia Angeloni, Alfonso Sestito, Fabio Infusino, Filippo Crea, Attilio Maseri et al.
Heart rate variability (HRV) and systemic markers of inflammation have prognostic value in patients with unstable angina pectoris (UAP). However, it is unknown whether any relation exists between HRV parameters and indexes of inflammation in this clinical context. We assessed HRV on 24-hour electrocardiographic Holter recordings, performed within 24 hours of admission, and measured C-reactive protein (CRP) serum levels by a high-sensitivity assay on admission, in 531 patients with UAP (65+/-10 years of age; 347 men) who were enrolled in the prospective multicenter study Stratificazione Prognostica dell'Angina Instabile (SPAI)...
June 15, 2006: American Journal of Cardiology
Stefano De Servi, Matteo Mariani, Pietro Vandoni, Antonio Dellavalle, Alessandro Politi, Fabrizio Poletti, Erminio Bonizzoni, Mario Leoncinie
Background In patients with non-ST elevation acute coronary syndrome (NST-ACS) that is treated invasively, glycoprotein (GP) IIb/IIIa inhibitors can be used either as upstream treatment in a coronary care unit or as downstream provisional treatment in selected patients who are undergoing percutaneous coronary intervention (PCI). The relative advantage of either strategy is unknown. The purpose of this study was to assess 30-day outcome of patients enrolled in a prospective NST-ACS registry and treated invasively with either of these two therapeutic strategies...
March 2006: Journal of Cardiovascular Medicine
G A Lanza, D Cianflone, A G Rebuzzi, G Angeloni, A Sestito, G Ciriello, G La Torre, F Crea, A Maseri et al.
OBJECTIVES: To assess the prognostic value of ventricular arrhythmias (VA) and heart rate variability (HRV) in patients with unstable angina. DESIGN: Multicentre prospective study. SETTING: 17 cardiological centres in Italy. PATIENTS: 543 consecutive patients with unstable angina and preserved left ventricular function (ejection fraction >or=40%) enrolled in the SPAI (Stratificazione Prognostica dell'Angina Instabile) study...
August 2006: Heart: Official Journal of the British Cardiac Society
Juliano L Fernandes, James L Orford, Concilia Garcia, Otavio R Coelho, Magnus Gidlund, Maria Heloisa S L Blotta
BACKGROUND: Autoantibodies to oxidized LDL (anti-oxLDL) have been found in the serum of patients with coronary artery disease (CAD). This study was designed to compare the differences in anti-oxLDL titers and isotypes in unstable and stable angina patients and to correlate these results with known markers of active inflammation in CAD. METHODS: Thirty patients from a tertiary referral general hospital with documented CAD were studied. Anti-oxLDL IgG titers and its isotypes, high sensitivity C-reactive protein (hsCRP) and serum amyloid A (SAA) were measured...
December 2004: Journal of Autoimmunity
(no author information available yet)
BACKGROUND: Despite advances in the treatment of non-ST-elevation acute coronary syndromes (ACS) based on randomized studies and published guidelines, the extent to which such treatments are applied in daily clinical practice remains elusive. The R.OS.A.I.-2 registry was undertaken to assess the modalities of the treatment of non-ST-elevation ACS, both in terms of the use of drugs, with particular attention to glycoprotein IIb/IIIa inhibitors and clopidogrel, as well as type of strategy, aggressive versus conservative, in a consecutive series of patients admitted to 76 coronary care units (CCU) in Italy...
November 2003: Italian Heart Journal: Official Journal of the Italian Federation of Cardiology
Hans Blomqvist, Kerstin Sondell
Anaemia is common in intensive care and its causes multifactorial. Blood transfusion is not without risks and the efficacy of stored blood to increase tissue oxygenation has been questioned. Still, transfusion is common; more than 80% of patients staying more than one week in ICU receive transfusion of more than one unit of red blood cells. Recent data in intensive care patients support that there might be a relation between transfusion and an increased incidence of nosocomial infections as well as increased mortality rate...
October 16, 2003: Läkartidningen
V Hricák, V Fridrich, V Fischer, P Margitfalvi, J Sumbal, S Mizera
BACKGROUND: Perioperative myocardial infarction (PMI) belongs to the main complications of revascularization surgery of the heart. Perioperative analysis of PIM risk factors can aid the cardiosurgeons, anestesiologists and cardiologists to stratify the group exposed to the risk of PIM origin and to prepare the most appropriate complex peroperative procedure for this group of patients. AIM: The particular aim is to evaluate and analyze some PIM risk factors prior to and during surgery...
February 1995: Bratislavské Lekárske Listy
F Balsano, P Rizzon, F Violi, D Scrutinio, C Cimminiello, F Aguglia, C Pasotti, G Rudelli
We conducted a controlled multicenter trial with central randomization and evaluation of events under blind conditions involving 652 patients with unstable angina. Patients were treated either with conventional therapy alone (group C) (n = 338) or with conventional therapy combined with an inhibitor of platelet aggregation, ticlopidine 250 mg b.i.d. (group C + T) (n = 314). Patients were assigned randomly within 48 hours of admission and followed up for 6 months. With the "intention-to-treat" approach, the primary end points, vascular death and nonfatal myocardial infarction, were observed in 13...
July 1990: Circulation
D Scrutinio, R Lagioia, P Rizzon
Data collected to investigate the effects of ticlopidine in a subset of 489 patients with angina at rest accompanied by transient ischaemic electrocardiographic changes have been analysed. Of the 489 patients, 255 received conventional treatment including beta-blockers, nitrates, or calcium antagonists (control group); 234 received conventional treatment plus ticlopidine 250 mg b.i.d. (ticlopidine group). The predefined end-points were vascular death and acute myocardial infarction (AMI). The incidence of end-points was assessed according to the intention-to-treat principle...
December 1991: European Heart Journal
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