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https://www.readbyqxmd.com/read/28105338/association-between-mmp-3-and-mmp-9-polymorphisms-and-coronary-artery-disease
#1
Osman Beton, Serdal Arslan, Burak Acar, Nil Ozbilum, Ocal Berkan
Matrix metalloproteinase (MMP)-3 and MMP-9 polymorphisms are characterized by plaque stability in coronary arteries. The aim of the current study was to investigate the 5A/6A polymorphism in the MMP-3 gene and C/T polymorphism in the MMP-9 gene in patients with coronary artery disease (CAD). The study population consisted of 400 patients who underwent coronary angiography. There were two groups consisting of 200 consecutive patients with CAD, presenting with stable angina pectoris, and 200 consecutive patients exhibiting normal coronary arteries...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28042398/quality-of-life-in-patients-with-coronary-artery-disease-and-panic-disorder-a-comparative-study
#2
Shruti Srivastava, Skand Shekhar, Manjeet Singh Bhatia, Shridhar Dwivedi
OBJECTIVES: The quality of life (QOL) of patients with coronary artery disease (CAD) is known to be impaired. Non-cardiac chest pain referrals are often under-diagnosed and untreated, and there are hardly any studies comparing the QOL of CAD and panic disorder related (non-cardiac) chest pain referrals (PDRC). METHODS: We assessed the psychiatric morbidity and QOL of patients newly diagnosed with CAD (n = 40) at baseline and six weeks post-treatment and compared their QOL with patients with PDRC (n = 40) and age- and gender-matched healthy controls (n = 57)...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/27999688/percutaneous-coronary-intervention-for-the-anomalous-left-coronary-artery-originating-from-the-noncoronary-cusp
#3
Toshiki Kuno, Yohei Numasawa, Toshiyuki Takahsashi
Percutaneous coronary intervention (PCI) for anomalous left coronary artery (LCA) originating from the noncoronary cusp (NCC) is challenging, as it poses difficulties with the engagement of the guiding catheter and the establishment of backup support. This report examines the case of a 69-year-old woman with unstable angina of anomalous LCA origin. The computed tomography showed a diffuse plaque in the middle of the left anterior descending (LAD) artery and an anomalous LCA originating from the NCC. After successful engagement of a straightened Judkins-Left diagnostic catheter, the angiography revealed a diffuse plaque in the middle of the LAD artery...
2016: Case Reports in Cardiology
https://www.readbyqxmd.com/read/27987040/lipid-lowering-therapy-stabilizes-the-complexity-of-non-culprit-plaques-in-human-coronary-artery-a-quantitative-assessment-using-oct-bright-spot-algorithm
#4
Yoshiyasu Minami, Taylor Hoyt, Jennifer E Phipps, Thomas E Milner, Lei Xing, Hang Lee, Bo Yu, Marc D Feldman, Ik-Kyung Jang
To quantitatively evaluate the change of plaque complexity with cholesterol lowering therapy. A total of 44 non-culprit plaques from 30 patients who had serial image acquisition at baseline, 6-months, and 12-months by both optical coherence tomography (OCT) and intravascular ultrasound (IVUS) were included. Patients were treated with atorvastatin 60 mg (AT60, n = 16) or 20 mg (AT20, n = 14). We applied an OCT bright spot algorithm, which identifies a variety of plaque components including macrophages...
December 16, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27970359/tct-189-comparison-of-5-year-clinical-outcomes-between-stabilized-acute-myocardial-infarction-patients-following-percutaneous-coronary-intervention-and-the-patients-with-angina-pectoris
#5
Ju Yeol Baek, Seung-Woon Rha, Byoung Geol Choi, Jae Kyeong Byun, Se Yeon Choi, Jun Hyuk Kang, Woo Hyeun Kim, Ja Yeon Choi, James Hall, Sung Hun Park, SunKi Lee, Hu Li, Jin Oh Na, Cheol Ung Choi, Jin Won Kim, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
No abstract text is available yet for this article.
November 1, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27875377/spinal-cord-stimulation-for-refractory-angina-pectoris-a-systematic-review-and-meta-analysis
#6
Xiaoxiao Pan, Hongguang Bao, Yanna Si, Chenjie Xu, Hao Chen, Xianzhong Gao, Xinyi Xie, Yajie Xu, Fan Sun, Lingqing Zeng
OBJECTIVES: Parasthesia free stimulation, such as high frequency and burst have been demonstrated as effective therapies for neuropathic pain. The aim of this meta-analysis was to evaluate the efficacy and safety of conventional spinal cord stimulation (SCS) in the treatment of refractory angina pectoris (RAP). METHODS: Relevant randomized controlled trial (RCT) studies that investigated SCS for patients with RAP were comprehensively searched in Medline, Pubmed, Embase, and Cochrane Library...
November 21, 2016: Clinical Journal of Pain
https://www.readbyqxmd.com/read/27844239/quantification-of-the-focal-progression-of-coronary-atherosclerosis-through-automated-co-registration-of-virtual-histology-intravascular-ultrasound-imaging-data
#7
Lucas H Timmins, David S Molony, Parham Eshtehardi, Emad Rasoul-Arzrumly, Adrian Lam, Olivia Y Hung, Michael C McDaniel, John N Oshinski, Don P Giddens, Habib Samady
The goal of this study was to evaluate the accuracy of a novel algorithm that circumferentially co-registers serial virtual histology-intravascular ultrasound (VH-IVUS) data for the focal assessment of coronary atherosclerosis progression. Thirty-three patients with an abnormal non-invasive cardiac stress test or stable angina underwent baseline and follow-up (6 or 12 months) invasive evaluation that included acquisition of VH-IVUS image data. Baseline and follow-up image pairs (n = 4194) were automatically co-registered in the circumferential direction via a multi-variate cross-correlation algorithm...
November 14, 2016: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/27822402/formulations-of-amlodipine-a-review
#8
REVIEW
Muhammad Ali Sheraz, Syed Furqan Ahsan, Marium Fatima Khan, Sofia Ahmed, Iqbal Ahmad
Amlodipine (AD) is a calcium channel blocker that is mainly used in the treatment of hypertension and angina. However, latest findings have revealed that its efficacy is not only limited to the treatment of cardiovascular diseases as it has shown to possess antioxidant activity and plays an important role in apoptosis. Therefore, it is also employed in the treatment of cerebrovascular stroke, neurodegenerative diseases, leukemia, breast cancer, and so forth either alone or in combination with other drugs. AD is a photosensitive drug and requires protection from light...
2016: Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27745841/surgical-unroofing-of-hemodynamically-significant-left-anterior-descending-myocardial-bridges
#9
Jack H Boyd, Vedant S Pargaonkar, David H Scoville, Ian S Rogers, Takumi Kimura, Shigemitsu Tanaka, Ryotaro Yamada, Michael P Fischbein, Jennifer A Tremmel, Robert Scott Mitchell, Ingela Schnittger
BACKGROUND: Left anterior descending artery myocardial bridges (MBs) range from clinically insignificant incidental angiographic findings to a potential cause of sudden cardiac death. Within this spectrum, a group of patients with isolated, symptomatic, and hemodynamically significant MBs despite maximally tolerated medical therapy exist for whom the optimal treatment is controversial. We evaluated supraarterial myotomy, or surgical unroofing, of the left anterior descending MBs as an isolated procedure in these patients...
October 1, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27515910/routine-invasive-versus-selective-invasive-strategies-for-non-st-elevation-acute-coronary-syndromes-an-updated-meta-analysis-of-randomized-trials
#10
Islam Y Elgendy, Dharam J Kumbhani, Ahmed N Mahmoud, Xuerong Wen, Deepak L Bhatt, Anthony A Bavry
OBJECTIVES: To perform an updated systematic review comparing a routine invasive strategy with a selective invasive strategy for patients with non-ST-elevation acute coronary syndromes (NSTE-ACS) in the era of stents and antiplatelet therapy. BACKGROUND: Recent meta-analyses comparing both strategies have shown conflicting results. METHODS: Electronic databases were searched for randomized trials that compared a routine invasive strategy (i...
August 12, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27436303/kidney-function-does-not-modify-the-favorable-quality-of-life-changes-associated-with-revascularization-for-coronary-artery-disease-cohort-study
#11
Matthew T James, Stephen B Wilton, Fiona M Clement, William A Ghali, Merril L Knudtson, Zhi Tan, Marcello Tonelli, Brenda R Hemmelgarn, Colleen M Norris
BACKGROUND: Although patients with kidney disease have potential to benefit from revascularization, they are also at higher risk of complications, which may affect quality of life. METHODS AND RESULTS: We studied a cohort of 8198 adults who underwent coronary angiography in Alberta, between 2004 and 2008, and completed health-related quality-of-life (HR-QOL) surveys. Changes in HR-QOL measures were most favorable among patients who received coronary artery bypass graft (CABG), but did not significantly differ by kidney function within groups of patients who received CABG, percutaneous coronary intervention (PCI), or medical therapy (P value for interaction between estimated glomerular filtration rate [eGFR] and revascularization status >0...
July 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27312021/-management-of-hypercholesterolemia-in-patients-with-acute-coronary-syndrome-current-mechanisms-and-future-perspectives
#12
Maddalena Lettino
Acute coronary syndromes (ACS) are a major health problem both in industrialized countries and in developing ones, and a leading cause of death and disability. The pathogenesis of ACS is multifactorial and complex, with approximately 65-70% of cases caused by the abrupt occlusion of a coronary vessel. This usually occurs as a result of thrombus formation over a vulnerable, lipid-rich atherosclerotic plaque, which undergoes rupture or erosion. High levels of LDL-cholesterol (LDL-C) are a well known risk factor for the development of atherosclerosis, and the reduction in plasma LDL-C is a fundamental treatment both in primary and secondary prevention...
April 2016: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/27256475/clinical-management-and-hospital-outcomes-of-acute-coronary-syndrome-patients-in-mexico-the-third-national-registry-of-acute-coronary-syndromes-renasica-iii
#13
Carlos Martinez-Sanchez, Gabriela Borrayo, Jorge Carrillo, Ursulo Juarez, Juan Quintanilla, Carlos Jerjes-Sanchez
OBJECTIVE: To describe current management and clinical outcomes in patients hospitalized with an acute coronary syndrome (ACS) in Mexico. METHODS: RENASICA III was a prospective multicenter registry of consecutive patients hospitalized with an ACS. Patients had objective evidence of ischemic heart disease; those with type II infarction or secondary ischemic were excluded. Study design conformed to current quality recommendations. RESULTS: A total of 123 investigators at 29 tertiary and 44 community hospitals enrolled 8296 patients with an ACS (4038 with non-ST-elevation myocardial infarction/unstable angina [NSTEMI/UA], 4258 with ST-elevation myocardial infarction [STEMI])...
July 2016: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/27231795/pillbox-use-and-inr-stability-in-a-prospective-cohort-of-new-warfarin-users
#14
Stephanie Dumas, Etienne Rouleau-Mailloux, Nawal Bouchama, Halema Lahcene, Mario Talajic, Jean-Claude Tardif, Marie-José Gaulin, Sylvie Provost, Marie-Pierre Dubé, Sylvie Perreault
BACKGROUND: Warfarin, a frequently prescribed oral anticoagulant, is well known for its narrow therapeutic index. Adherence to warfarin may help to achieve a stable international normalized ratio (INR), but little data are available regarding the impact of using a pillbox as a potential adherence aid device. OBJECTIVE: To evaluate the association between pillbox use and time in therapeutic range (TTR) < 60% and INR instability pattern. METHODS: This study was based on a prospective cohort of 1,069 new warfarin users who initiated warfarin between May 2010 and July 2013 within 17 hospitals in Quebec, Canada...
June 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27101443/high-plasma-levels-of-gremlin-1-and-macrophage-migration-inhibitory-factor-but-not-their-ratio-indicate-an-increased-risk-for-acute-coronary-syndrome-in-patients-with-type-2-diabetes-mellitus
#15
Karin A L Müller, Dominik Rath, Martina Schmid, Heiko Schoenleber, Meinrad Gawaz, Tobias Geisler, Iris I Müller
BACKGROUND: Chronic inflammation promotes atherosclerosis and is a prognostic factor in coronary artery disease (CAD). Patients with type 2 diabetes mellitus (DM2) are at risk for progressive atherosclerosis. Macrophage migration inhibitory factor (MIF) is a key player in atherosclerosis, mediating pro-inflammatory responses. Its endogenous antagonist Gremlin-1 inhibits foam-cell formation and atheroprogression by binding MIF, neutralizing its proatherosclerotic functions. HYPOTHESIS: Plasma levels of MIF and Gremlin-1 correlate with the stability of CAD in patients with DM2...
April 2016: Clinical Cardiology
https://www.readbyqxmd.com/read/27063592/development-of-fast-dissolving-oral-films-containing-lercanidipine-hcl-nanoparticles-in-semicrystalline-polymeric-matrix-for-enhanced-dissolution-and-ex-vivo-permeation
#16
Ankita D Chonkar, J Venkat Rao, Renuka S Managuli, Srinivas Mutalik, Swapnil Dengale, Prateek Jain, N Udupa
Lercanidipine is a vasoselective dihydropyridine calcium antagonist, mainly used for the treatment of hypertension and angina pectoris. However, it suffers from food dependent absorption, poor solubility, low permeability and considerable first pass metabolism, resulting in highly variable and low bioavailability of 10%. Nanoparticles of lercanidipine were incorporated in fast dissolving oral films (FDO) via preparation of nanosuspension by evaporative antisolvent precipitation method. Prepared nanosuspensions were incorporated in FDO without lyophilizing or spray drying...
June 2016: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/27021556/anti-anginal-and-metabolic-effects-of-carvedilol-and-atenolol-in-patients-with-stable-angina-pectoris-a-prospective-randomized-parallel-open-label-study
#17
RANDOMIZED CONTROLLED TRIAL
Pyung Chun Oh, Woong Chol Kang, Jeonggeun Moon, Yae Min Park, Sihun Kim, Myeong Gun Kim, Kyounghoon Lee, Taehoon Ahn, Eak Kyun Shin
BACKGROUND: While recent guidelines have suggested the potential for beta-blockers as first-line agents in chronic stable angina, few data regarding comparative anti-anginal and metabolic effects between beta-blockers with and without vasodilating properties have been reported, particularly in patients with angina pectoris. OBJECTIVE: Our objective was to compare the anti-anginal and metabolic effects of carvedilol and atenolol in patients with stable angina pectoris...
June 2016: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/26985211/the-guideliner-catheter-a-useful-tool-in-the-armamentarium-of-the-interventional-cardiologist
#18
Marouane Boukhris, Salvatore Azzarelli, Salvatore Davide Tomasello, Zied Ibn Elhadj, Francesco Marzà, Alfredo R Galassi
Regardless of the clinical setting, a good back-up represents one of the most important conditions to ensure guide wire and balloon advancement and stent delivery. As a "mother and child" system, the GuideLiner catheter (Vascular Solutions Inc., Minneapolis, MN, USA) provides an extension to the guide catheter with better coaxial alignment and stability. We report two didactic cases showing the usefulness of the GuideLiner device in everyday catheterization laboratory practice. The first case was a primary percutaneous coronary intervention (PCI) in a 71-year-old diabetic man admitted for inferior ST-elevation myocardial infarction, related to tight proximal stenosis in a dominant tortuous and calcified left circumflex...
October 27, 2015: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/26945433/association-between-statin-treatment-and-ldl-cholesterol-levels-on-the-rate-of-st-elevation-myocardial-infarction-among-patients-with-acute-coronary-syndromes-acs-israeli-survey-acsis-2002-2010
#19
MULTICENTER STUDY
Shmuel Gottlieb, Shimon Kolker, Nir Shlomo, Shlomi Matetzky, Eran Leitersdorf, Amit Segev, Ilan Goldenberg, Dan Tzivoni, Giora Weisz, Mady Moriel
BACKGROUND: STEMI is thought to occur as a result of a vulnerable coronary plaque rupture. Statins possess hypolipidemic and pleotropic effects that stabilize coronary plaque. We sought to determine the association between LDL-C levels, statin use prior to the index event on the type of acute coronary syndrome (ACS) presentation: STEMI vs. non-STEMI/unstable angina. METHODS: Data was drawn from the ACS Israeli Survey (ACSIS), a biennial prospective survey of ACS patients hospitalized in all CCU/Cardiology departments during 2002-2010...
May 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/26894054/evaluation-of-serum-pregnancy-associated-plasma-protein-a-plasma-d-dimer-in-acute-coronary-syndrome
#20
Gautam Nichenametla, Vivian Samuel Thomas
INTRODUCTION: Acute coronary syndrome (ACS), a spectrum comprising unstable angina pectoris, ST Elevated Myocardial Infarction (STEMI) & Non ST Elevated Myocardial Infarction (NSTEMI) is the major cause of presentation in Emergency Department today. Though ECG and cardiac enzymes are used for diagnosis, they mislead the diagnosis sometimes and delay in treatment initiation. This leads us to search certain new parameters which reflect the pathophysiology of ACS. Markers of plaque stability like Pregnancy Associated Plasma Protein-A and D-Dimer, a marker of ongoing thrombosis are found to be better markers in early diagnosis...
January 2016: Journal of Clinical and Diagnostic Research: JCDR
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