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Iron and neonate

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https://www.readbyqxmd.com/read/29765787/liver-failure-and-conjugated-hyperbilirubinemia-in-a-preterm-neonate-role-of-early-ivig-and-exchange-transfusion
#1
Jayasree Nair, Vasantha H S Kumar
Neonatal liver failure (NLF) is a rare diagnosis but carries with it significant risks of mortality and morbidity. Common etiologies for NLF include metabolic causes, gestational alloimmune liver disease (GALD or neonatal hemochromatosis), and viral infections. We report a case of liver failure in a premature infant with abnormal iron profile within 48 hours of birth. Lack of accepted guidelines for the initial management of severe jaundice with a high direct component in the first week after birth made treatment challenging...
April 2018: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/29746715/quantitative-susceptibility-map-analysis-in-preterm-neonates-with-germinal-matrix-intraventricular-hemorrhage
#2
Domenico Tortora, Mariasavina Severino, Jan Sedlacik, Benedetta Toselli, Mariya Malova, Alessandro Parodi, Giovanni Morana, Marco Massimo Fato, Luca Antonio Ramenghi, Andrea Rossi
BACKGROUND: Germinal matrix-intraventricular hemorrhage (GMH-IVH) is a common form of intracranial hemorrhage occurring in preterm neonates that may affect normal brain development. Although the primary lesion is easily identified on MRI by the presence of blood products, its exact extent may not be recognizable with conventional sequences. Quantitative susceptibility mapping (QSM) quantify the spatial distribution of magnetic susceptibility within biological tissues, including blood degradation products...
May 10, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29740690/treatment-of-iron-deficiency-and-iron-deficiency-anemia-with-intravenous-ferric-carboxymaltose-in-pregnancy
#3
Bernd Froessler, Tijana Gajic, Gustaaf Dekker, Nicolette A Hodyl
PURPOSE: To evaluate the efficacy and safety of intravenous ferric carboxymaltose administration to pregnant women with varying severities of iron deficiency anemia and iron deficiency without anemia. METHODS: In this prospective observational study of local obstetric practice, we analyzed data from 863 pregnant women with iron deficiency according to anemia status and severity. All women were treated with intravenous ferric carboxymaltose in pregnancy. Treatment efficacy was assessed by repeat hemoglobin measurements at 3 and 6 week post-infusion and ferritin levels, where available...
May 8, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29699508/factors-associated-with-congenital-anomalies-in-addis-ababa-and-the-amhara-region-ethiopia-a-case-control-study
#4
Molla Taye, Mekbeb Afework, Wondwossen Fantaye, Ermias Diro, Alemayehu Worku
BACKGROUND: The early stage of embryo development is extremely vulnerable to various teratogenic factors, leading to congenital anomalies. In Ethiopia, a significant number of babies are born with congenital anomalies, but the risk factors for the anomalies have never been studied. Understanding the specific risk factors for congenital anomalies is very essential to provide health education that aims at creating awareness and establishing preventive strategic plan/s. The main objective of this study was to assess the risk factors associated with congenital anomalies in Addis Ababa and the Amhara Region, Ethiopia...
April 25, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29685119/prevalence-risk-factors-and-associated-adverse-pregnancy-outcomes-of-anaemia-in-chinese-pregnant-women-a-multicentre-retrospective-study
#5
Li Lin, Yumei Wei, Weiwei Zhu, Chen Wang, Rina Su, Hui Feng, Huixia Yang
BACKGROUND: Anaemia in pregnant women is a public health problem, especially in developing countries. The aim of this study was to assess the prevalence and related risk factors of anaemia during pregnancy in a large multicentre retrospective study (n = 44,002) and to determine the adverse pregnancy outcomes in women with or without anaemia. METHODS: The study is a secondary data analysis of a retrospective study named "Gestational diabetes mellitus Prevalence Survey (GPS) study in China"...
April 23, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29680986/effect-of-placental-transfusion-on-iron-stores-in-moderately-preterm-neonates-of-30-33-weeks-gestation-correspondence
#6
REVIEW
Viraraghavan Vadakkencherry Ramaswamy
No abstract text is available yet for this article.
April 21, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29662712/do-syrian-refugees-have-increased-risk-for-worser-pregnancy-outcomes-results-of-a-tertiary-center-in-%C3%A4-stanbul
#7
Emre Sinan Güngör, Olcay Seval, Gülşah İlhan, Fatma Ferda Verit
Objective: To compare obstetric and perinatal outcomes of Syrian refugee pregnants and Turkish counterparts who gave birth at a tertiary center in İstanbul. Materials and Methods: A retrospective study including the birth records of 704 Syrian refugees and 744 Turkish pregnant women between January 2016 and May 2017 were analyzed. Demographic data, obstetric and neonatal outcomes were compared. The primary aims of this study were to evaluate the pregnancy outcomes and cesarean rates between the groups...
March 2018: Turkish Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29652240/umbilical-cord-coiling-in-high-risk-pregnancies-associations-with-determinants-of-adverse-birth-outcomes-and-iron-status
#8
Gabrielle K Steinl, Jocelyn S Gandelman, Philip J Katzman, Yuan Ru, Ronnie Guillet, Eva Pressman, Elizabeth M Cooper, Kimberly O O'Brien
Abnormal umbilical cord coiling has been associated with adverse neonatal outcomes, but the etiology of these findings remains poorly characterized. This study was undertaken to examine associations between cord coiling and maternal iron (Fe) status and to identify potential determinants of hypo- and hypercoiling in 2 higher risk obstetric groups: pregnant adolescents (≤18 years, n = 92) and adult women carrying twins (n = 49), triplets (n = 11), or quadruplets (n = 1). Umbilical cords were classified as hypo-, normo-, or hypercoiled using digital photographs to assess gross appearance...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29625173/brain-mitochondrial-iron-accumulates-in-huntington-s-disease-mediates-mitochondrial-dysfunction-and-can-be-removed-pharmacologically
#9
Sonal Agrawal, Julia Fox, Baskaran Thyagarajan, Jonathan Fox
Mitochondrial bioenergetic dysfunction is involved in neurodegeneration in Huntington's disease (HD). Iron is critical for normal mitochondrial bioenergetics but can also contribute to pathogenic oxidation. The accumulation of iron in the brain occurs in mouse models and in human HD. Yet the role of mitochondria-related iron dysregulation as a contributor to bioenergetic pathophysiology in HD is unclear. We demonstrate here that human HD and mouse model HD (12-week R6/2 and 12-month YAC128) brains accumulated mitochondrial iron and showed increased expression of iron uptake protein mitoferrin 2 and decreased iron-sulfur cluster synthesis protein frataxin...
April 3, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29622875/study-of-complete-haemogram-and-iron-profile-from-cord-blood-of-newborn-with-respect-to-primigravida-multigravida-and-apgar-score
#10
Madhumita Mondal, Swapan Kumar Sinha, Moumita Sengupta, Debdas Bose, Sudip Saha, Utpal Chaudhuri
Study of different parameters of cord blood usually reflects neonatal health status. One of the widely used system for assessing neonatal health is APGAR score. It is assed at 1 and 5 min from baby's birth. Immediate medical care may improve 5 min score of neonate who showed poor score at 1 min. The main objective of this study is to establish whether any correlation exists between complete hemogram and iron profile with APGAR score and gravid of mother. Cord blood was collected from 96 new born, delivered vaginally, mothers having no chronic medical disease...
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29603266/source-and-quality-of-enteral-nutrition-influences-oxidative-stress-in-preterm-infants-a-prospective-cohort-study
#11
Gerhard Fusch, Souvik Mitra, Heinrich Topp, Arnav Agarwal, So Hon Yiu, Josefin Bruhs, Niels Rochow, Anja Lange, Matthias Heckmann, Christoph Fusch
BACKGROUND: Preterm infants are at risk of oxidative stress from neonatal intensive care interventions. 8-Oxo-2'-deoxyguanosine (8-oxodG), generated by oxygen radical attack on DNA, is a potential marker of oxidative stress. The aim of the present study was to investigate the impact of quality and source of enteral nutrition (EN) on renal excretion of 8-oxodG in preterm infants. METHODS: Spontaneous urine samples were collected on postnatal days 26-31 in 33 preterm infants...
March 30, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29599516/enterobacter-bugandensis-a-novel-enterobacterial-species-associated-with-severe-clinical-infection
#12
Niladri Bhusan Pati, Swapnil Prakash Doijad, Tilman Schultze, Gopala Krishna Mannala, Yancheng Yao, Sangeeta Jaiswal, Daniel Ryan, Mrutyunjay Suar, Konrad Gwozdzinski, Boyke Bunk, Mobarak Abu Mraheil, Mohamed A Marahiel, Julian D Hegemann, Cathrin Spröer, Alexander Goesmann, Linda Falgenhauer, Torsten Hain, Can Imirzalioglu, Stephen E Mshana, Jörg Overmann, Trinad Chakraborty
Nosocomial pathogens can cause life-threatening infections in neonates and immunocompromised patients. E. bugandensis (EB-247) is a recently described species of Enterobacter, associated with neonatal sepsis. Here we demonstrate that the extended spectrum ß-lactam (ESBL) producing isolate EB-247 is highly virulent in both Galleria mellonella and mouse models of infection. Infection studies in a streptomycin-treated mouse model showed that EB-247 is as efficient as Salmonella Typhimurium in inducing systemic infection and release of proinflammatory cytokines...
March 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29579916/effect-of-technological-treatments-on-bovine-lactoferrin-an-overview
#13
REVIEW
Indira Franco, María Dolores Pérez, Celia Conesa, Miguel Calvo, Lourdes Sánchez
Lactoferrin (LF) is a multifunctional protein that exerts important activities in the neonate through its presence in milk, and also in other external mucosas, acting as a defense protein of innate immunity. The addition of bovine LF to infant formula and also to other functional products and cosmetics has increased during the last decades. Consequently, it is essential to know the effect that the technological processes, necessary to elaborate those products, have on LF activity. In this study, we have revised the effect of classical treatments on lactoferrin structure and activity, such as heat treatment or drying, and also of emerging technologies, like high pressure or pulsed electric field...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29532452/hepcidin-an-iron-regulatory-hormone-of-innate-immunity-is-differentially-expressed-in-premature-fetuses-with-early-onset-neonatal-sepsis
#14
Sammy M Tabbah, Catalin S Buhimschi, Katherine Rodewald-Millen, Christopher R Pierson, Vineet Bhandari, Philip Samuels, Irina A Buhimschi
OBJECTIVE:  Hepcidin, a mediator of innate immunity, binds the iron exporter ferroportin, leading to functional hypoferremia through intracellular iron sequestration. We explored hepcidin-ferroportin interactions in neonates clinically diagnosed with early-onset neonatal sepsis (EONS). STUDY DESIGN:  Hepcidin and interleukin (IL)-6 were quantified by enzyme-linked immunosorbent assay (ELISA) in 92 paired cord blood-maternal blood samples in the following groups: "Yes" EONS ( n  = 41, gestational age [GA] 29 ± 1 weeks) and "No" EONS ( n  = 51, GA 26 ± 1 weeks)...
February 2, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29506014/effect-of-milking-maneuver-in-preterm-infants-a-randomized-controlled-trial
#15
Víctor Lago Leal, Loida Pamplona Bueno, Lucía Cabanillas Vilaplana, Estefanía Nicolás Montero, Mónica Martín Blanco, Cristina Fernández Romero, Sara El Bakkali, Tamara Pradillo Aramendi, Lara Sobrino Lorenzano, Paula Castellano Esparza, Esther Ballesteros Benito, Nieves Rayo Navarro, Pablo Del Barrio Fernández, Vanesa Ocaña Martínez, Luis Martínez Cortés
OBJECTIVE: To assess the short and medium-term effects of milking maneuver (MM) compared with early cord clamping for infants born before 37 weeks of pregnancy. MATERIAL AND METHODS: 138 infants between 24+0 and 36+6 weeks of gestation were allocated to MM or early cord clamping. Primary outcomes were the requirement of red blood cell transfusions or phototherapy. RESULTS: Initial hemoglobin was significantly higher in the MM group by 1.675 g/dL (p < 0...
March 5, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29493902/integrating-nutrition-into-health-systems-at-community-level-impact-evaluation-of-the-community-based-maternal-and-neonatal-health-and-nutrition-projects-in-ethiopia-kenya-and-senegal
#16
Jacqueline K Kung'u, Richard Pendame, Mame Bineta Ndiaye, Mulusew Gerbaba, Sophie Ochola, Adama Faye, Sulochana Basnet, Edward A Frongillo, Sara Wuehler, Luz Maria De-Regil
Maternal undernutrition and mortality remain high in several African countries. Key nutrition and health interventions improve maternal and birth outcomes. Evidence is scarce on how to strengthen health systems to ensure pregnant women and newborns are reached with these interventions. We conducted three quasi-experimental nonrandomized Community Based Maternal and Neonatal Health and Nutrition projects in regions of Ethiopia, Senegal, and Kenya to demonstrate how proven nutrition interventions could be integrated into health programs to improve knowledge and practices during pregnancy, birth, and postpartum...
February 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29476317/atypical-erythroblastosis-in-a-patient-with-diamond-blackfan-anemia-who-developed-del-20q-myelodysplasia
#17
Motoshi Sonoda, Masataka Ishimura, Yuko Ichimiya, Eiko Terashi, Katsuhide Eguchi, Yasunari Sakai, Hidetoshi Takada, Asahito Hama, Hitoshi Kanno, Tsutomu Toki, Etsuro Ito, Shouichi Ohga
Diamond-Blackfan anemia (DBA) is a congenital red cell aplasia arising from ribosomal protein (RP) defects. Affected patients present with neonatal anemia, occasional dysmorphism, and cancer predisposition. An anemic newborn was diagnosed with DBA due to RPL5 mutation (c.473_474del, p.K158SfsX26). Refractory anemia required regular transfusions and iron chelation therapy. Pancytopenia occurred at age 16 years. Bone-marrow studies showed myelodysplasia, erythroblastosis, and clonal evolution of del(20)(q11...
February 23, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29420411/maternal-and-perinatal-outcomes-after-laparoscopic-sleeve-gastrectomy
#18
Amihai Rottenstreich, Uriel Elchalal, Geffen Kleinstern, Nahum Beglaibter, Abed Khalaileh, Ram Elazary
OBJECTIVE: To examine associations of laparoscopic sleeve gastrectomy with maternal and perinatal outcomes. METHODS: We conducted a retrospective case-control study of deliveries that occurred from 2006 to 2016 at two university hospitals. The study group comprised all women who had undergone laparoscopic sleeve gastrectomy and who delivered during the study period. If a woman had more than one pregnancy during the study period, data from only her first pregnancy were used...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29415674/observations-on-the-health-of-infants-at-a-time-of-rapid-societal-change-a-longitudinal-study-from-birth-to-fifteen-months-in-abu-dhabi
#19
Hazel Gardner, Katherine Green, Andrew S Gardner, Donna Geddes
BACKGROUND: Rapid economic and cultural transition in the United Arab Emirates has been accompanied by a rise in chronic disease. Early childhood is known to affect health outcomes in adulthood. This prospective longitudinal study examined the general health of Emirati infants born in a government maternity hospital in the Emirate of Abu Dhabi in October 2002. METHODS: One hundred twenty-five women, who had recently given birth, were interviewed as part of a larger study encompassing a wide range of cultural, social, and behavioural aspects of health...
February 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29407004/breast-milk-is-conditionally-perfect
#20
Miriam Erick
Breast milk is the universal preferred nutrition for the newborn human infant. New mother have been encouraged to exclusively breastfeed by health care professionals and consumer-advocacy forums for years, citing "breast milk is the perfect food". The benefits are numerous and include psychological, convenience, economical, ecological and nutritionally superior. Human milk is a composite of nutritional choices of the mother, commencing in the pre-conceptual era. Events influencing the eventual nutritional profile of breast milk for the neonate start with pre-conceptual dietary habits through pregnancy and finally to postpartum...
February 2018: Medical Hypotheses
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