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Iron and very low birth weight infant

B C MacQueen, R D Christensen, D M Ward, S T Bennett, E A O'Brien, M J Sheffield, V L Baer, G L Snow, K A Weaver Lewis, R E Fleming, J Kaplan
OBJECTIVE: Small-for-gestational-age (SGA) neonates, infants of diabetic mothers (IDM) and very-low-birth weight premature neonates (VLBW) are reported to have increased risk for developing iron deficiency and possibly associated neurocognitive delays. STUDY DESIGN: We conducted a pilot study to assess iron status at birth in at-risk neonates by measuring iron parameters in umbilical cord blood from SGA, IDM, VLBW and comparison neonates. RESULTS: Six of the 50 infants studied had biochemical evidence of iron deficiency at birth...
December 15, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Grzegorz Majka, Grażyna Więcek, Małgorzata Śróttek, Klaudyna Śpiewak, Małgorzata Brindell, Joanna Koziel, Janusz Marcinkiewicz, Magdalena Strus
Translocation of bacteria, primarily Gram-negative pathogenic flora, from the intestinal lumen into the circulatory system leads to sepsis. In newborns, and especially very low birth weight infants, sepsis is a major cause of morbidity and mortality. The results of recently conducted clinical trials suggest that lactoferrin, an iron-binding protein that is abundant in mammalian colostrum and milk, may be an effective agent in preventing sepsis in newborns. However, despite numerous basic studies on lactoferrin, very little is known about how metal saturation of this protein affects a host's health...
December 2016: Biometals: An International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Masayuki Ochiai, Hiroaki Kurata, Hirosuke Inoue, Koichi Tanaka, Yuki Matsushita, Junko Fujiyoshi, Yoshifumi Wakata, Kiyoko Kato, Tomoaki Taguchi, Hidetoshi Takada
BACKGROUND: The substantial risk of iron overload is not routinely monitored in most of the neonatal intensive care units (NICUs) in Japan; however, blood transfusion is an essential strategy for successfully treating preterm low-birth-weight infants. OBJECTIVE: The aim of this study was to investigate the iron status and clinical features of infants with a birth weight of <1,500 g, i.e. very-low-birth-weight infants (VLBWIs). METHODS: This prospective observational study enrolled 176 (82...
2017: Neonatology
Sook-Hyun Park, Heng-Mi Kim
PURPOSE: We investigated the iron status of very low birth weight infants receiving multiple erythrocyte transfusions during hospitalization in the neonatal intensive care unit (NICU). METHODS: We enrolled 46 very low birth weight infants who were admitted to the Kyungpook National University Hospital between January 2012 and December 2013. Serum ferritin was measured on their first day of life and weekly thereafter. We collected individual data of the frequency and volume of erythrocyte transfusion and the amount of iron intake...
June 2015: Pediatric Gastroenterology, Hepatology & Nutrition
Alper I Dai, Seniz Demiryürek, Sefika Nur Aksoy, Peren Perk, Oguzhan Saygili, Kivanc Güngör
BACKGROUND: Retinopathy of prematurity is a proliferative vascular disease affecting premature newborns and occurs during vessel development and maturation. The aim of this study was to evaluate the maternal iron deficiency anemia as possible risk factors associated with the development of retinopathy of prematurity among premature or very low birth weight infants. METHODS: In this study, mothers of 254 infants with retinopathy of prematurity were analyzed retrospectively, and their laboratory results of medical records during pregnancy were reviewed for possible iron deficiency anemia...
August 2015: Pediatric Neurology
Raeda T Al-Ghananim, Demet Nalbant, Robert L Schmidt, Gretchen A Cress, M Bridget Zimmerman, John A Widness
BACKGROUND: Reticulocyte hemoglobin content (RET-He)-an established indicator of iron status in children and adults-was determined in very low birth weight (VLBW) infants. METHODS: Longitudinal retrospective RET-He data in 26 VLBW neonates during the first month of age were compared with: (a) concurrent complete blood counts (CBCs), including hemoglobin (Hb) concentration, reticulocyte count, and immature reticulocyte fraction (IRF), and erythropoietin (EPO) levels; (b) clinical variables; and (c) RET-He data from the literature for term infants, children, and adults...
July 2016: Journal of Clinical Laboratory Analysis
Hong-Xing Jin, Rong-Shan Wang, Shu-Jun Chen, Ai-Ping Wang, Xi-Yong Liu
BACKGROUND: Iron deficiency in infancy is associated with a range of clinical and developmentally important issues. Currently, it is unclear what is the optimal timing to administer prophylactic enteral iron supplementation in preterm and very low birth weight infants. The objective of this meta-analysis was to evaluate early compared with late iron supplementation in low birth weight infants. METHODS: PubMed and Cochrane Library databases were searched up to May 10, 2014 for studies that compared the benefit of early and late iron supplementation in infants of low birth weight...
2015: Italian Journal of Pediatrics
Laila Lorenz, Jörg Arand, Katja Büchner, Annette Wacker-Gussmann, Andreas Peter, Christian F Poets, Axel R Franz
OBJECTIVE: To evaluate reticulocyte haemoglobin content (CHr), compared with ferritin, transferrin saturation (TS) and mean corpuscular volume (MCV), as a marker of iron deficiency (ID). DESIGN: Retrospective analysis of clinically indicated blood samples taken between February 2010 and October 2012. SETTING: Single-centre neonatal care unit. PATIENTS: 210 very preterm (gestational age <32 weeks) or very low birthweight infants (birth weight <1500 g) at 3-4 months corrected age...
May 2015: Archives of Disease in Childhood. Fetal and Neonatal Edition
Meera Khorana, Chanin Jiamsajjamongkhon
BACKGROUND: Nutrition is an important aspect in the care of very low birth weight (VLBW) preterm infants. Human milk fortified with human milk fortifiers (HMF) is best for enteral feeding of premature infants. HMF is expensive and not easily available in Thailand. Post discharge formula (PDF) has been routinely used to fortify human milk at Queen Sirikit National Institute of Child Health (QSNICH) but there is lack of supportive data regarding efficacy and safety. OBJECTIVE: To study and compare anthropometrics, biochemical markers and complications in VLBW infants fed human milk fortified with either HMF or PDF...
June 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
Laila Lorenz, Johanna Herbst, Corinna Engel, Andreas Peter, Harald Abele, Christian F Poets, Mark Westerman, Axel R Franz
BACKGROUND: Iron deficiency (ID) contributes to anaemia of prematurity, and hence the reliable assessment of iron nutrition status appears to be mandatory. OBJECTIVE: To establish gestational age (GA)-specific reference ranges for hepcidin concentrations in cord blood [Hep(CB)] of preterm and term infants and to identify pre- and perinatal confounding factors. METHODS: This is a prospective observational study including 221 infants (GA at birth: 24-42 weeks)...
2014: Neonatology
Sourabh Datta, Deepak Bansal, Pankaj Garg
No abstract text is available yet for this article.
April 2014: Indian Pediatrics
Magnus Domellöf
Microminerals, including iron, zinc, copper, selenium, manganese, iodine, chromium and molybdenum, are essential for a remarkable array of critical functions and need to be supplied in adequate amounts to preterm infants. Very low birth weight (VLBW) infants carry a very high risk of developing iron deficiency which can adversely affect neurodevelopment. However, a too high iron supply in iron-replete VLBW infants may induce adverse effects such as increased infection risks and impaired growth. Iron needs are influenced by birth weight, growth rates, blood losses (phlebotomy) and blood transfusions...
2014: World Review of Nutrition and Dietetics
Jasim Anabrees
No abstract text is available yet for this article.
January 2014: Journal of Clinical Neonatology
Rojo Joy, Sriram Krishnamurthy, Adhisivam Bethou, Medha Rajappa, P H Ananthanarayanan, B Vishnu Bhat
OBJECTIVES: To evaluate whether preterm very low birth weight (VLBW) infants receiving early iron (EI) supplementation (2 mg/kg/day elemental iron) at 2 weeks postnatal age have improved serum ferritin levels compared with late iron (LI) supplementation at 6 weeks postnatal age. DESIGN: Single-blinded parallel-group interventional randomised controlled trial. SETTING: Tertiary care centre in southern India. INTERVENTIONS: Randomised at 2 weeks postnatal age to EI and LI groups and evaluated at 2, 6 and 12 weeks postnatal age...
March 2014: Archives of Disease in Childhood. Fetal and Neonatal Edition
Cláudia Ferri, Renato S Procianoy, Rita C Silveira
OBJECTIVE: To determine the prevalence of iron-deficiency anemia and iron deficiency at 1 year of corrected age (CA) in preterm very-low-birth-weight infants, and to identify risk factors for iron-deficiency anemia. METHODS: A cohort of infants with birth weight <1500 g and gestational age <34 weeks on iron prophylaxis were followed up to 12 months' CA. Anemia diagnosis was based on hemoglobin <11 g/dl. Iron deficiency was defined by ferritin levels <10 μg/l, transferrin saturation <10% and mean corpuscular volume <80 fl...
February 2014: Journal of Tropical Pediatrics
Magnus Domellöf
Low birthweight (LBW), defined as birthweight <2,500 g, is a major global public health problem and is associated with lifelong cognitive and behavioral problems. Very LBW (VLBW) infants (<1,500 g) are at high risk of multiple macro- and micronutrient deficiencies, but most LBW infants are larger (1,500-2,500 g), and the most common nutritional problem of those infants is iron deficiency (ID). Globally, about 25% of pre-school children have ID anemia (IDA), the most severe form of ID, and there is good evidence that ID is associated with impaired brain development...
2013: Nestlé Nutrition Institute Workshop Series
Robin K Ohls, Robert D Christensen, Beena D Kamath-Rayne, Adam Rosenberg, Susan E Wiedmeier, Mahshid Roohi, Conra Backstrom Lacy, Diane K Lambert, Jill J Burnett, Barbara Pruckler, Ron Schrader, Jean R Lowe
BACKGROUND: A novel erythropoiesis stimulating agent (ESA), darbepoetin alfa (Darbe), increases hematocrit in anemic adults when administered every 1 to 3 weeks. Weekly Darbe dosing has not been evaluated in preterm infants. We hypothesized that infants would respond to Darbe by decreasing transfusion needs compared with placebo, with less-frequent dosing than erythropoietin (Epo). METHODS: Preterm infants 500 to 1250 g birth weight and ≤48 hours of age were randomized to Darbe (10 μg/kg, 1 time per week subcutaneously), Epo (400 U/kg, 3 times per week subcutaneously) or placebo (sham dosing) through 35 weeks' gestation...
July 2013: Pediatrics
B H N Yasmeen, M A K A Chowdhury, M M Hoque, M M Hossain, R Jahan, S Akhtar
Premature infants especially those with birth weight < 1500 g suffer from Anaemia of prematurity (AOP) and associated problems. Erythropoietin therapy is a safe effective way to prevent and to treat anaemia of prematurity. To evaluate the effect of short-term administration of recombinant human erythropoietin (rHuEPO) with iron and folic acid in very low birth weight (VLBW) neonates in the prevention of anaemia of prematurity. A randomized controlled trial was carried out at Dhaka Shishu Hospital. Sixty preterm very low birth weight (PTVLBW) babies were enrolled in this study...
December 2012: Bangladesh Medical Research Council Bulletin
Tiffany A Taylor, Kathleen A Kennedy
OBJECTIVE: To determine if iron supplementation of 2 mg/kg per day, in addition to routine iron-fortified formula or mother's milk, increased the hematocrit (Hct) at 36 weeks' postmenstrual age (PMA). METHODS: : Infants with a birth weight <1500 g who reached 120 mL/kg per day of feedings before 32 weeks' PMA were randomly assigned to iron (multivitamin with iron) or control (multivitamin) from enrollment until 36 weeks' PMA (or discharge, if sooner). Investigators and caregivers were masked...
February 2013: Pediatrics
George R Buchanan
No abstract text is available yet for this article.
February 2013: Pediatrics
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