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Allostatic load

Robert-Paul Juster, Jennifer J Russell, Daniel Almeida, Martin Picard
Stress-related pathophysiology drives comorbid trajectories that elude precise prediction. Allostatic load algorithms that quantify biological "wear and tear" represent a comprehensive approach to detect multisystemic disease processes of the mind and body. However, the multiple morbidities directly or indirectly related to stress physiology remain enigmatic. Our aim in this article is to propose that biological comorbidities represent discrete pathophysiological processes captured by measuring allostatic load...
November 2016: Development and Psychopathology
José M Causadias, Eva H Telzer, Richard M Lee
Objective: Culture and biology have evolved together, influence each other, and concurrently shape behavior, affect, cognition, and development. This special section highlights 2 major domains of the interplay between culture and biology. Method: The first domain is neurobiology of cultural experiences-how cultural, ethnic, and racial experiences influence limbic systems and neuroendocrine functioning-and the second domain is cultural neuroscience-the connections between cultural processes and brain functioning...
August 15, 2016: Cultural Diversity & Ethnic Minority Psychology
Gary D James
Variability is a normative property of blood pressure necessary for survival which likely contributes to morbidity and mortality through allostatic load. Because of its allostatic and adaptive properties blood pressure responses to peculiar situations like the visit to the clinic can lead to the misdiagnosis of hypertension. Cuff methods of blood pressure measurement can also create blood pressure variation when there really is none. There are also physiological differences between populations related to their evolutionary history that likely further affect the extent of population differences in 24-h blood pressure variability...
October 9, 2016: Advances in Experimental Medicine and Biology
Ola Sayed Ali, Nadia Badawy, Sanaa Rizk, Hend Gomaa, Mai Sabry Saleh
AIM: Workplace stress is hazardous for its harmful impact on employees' health and organizational productivity. The aim of the study is to apply the Allostatic Load Index (ALI) which is a multi-component measure for health risk assessment and early detection of stress among workers in Egypt. METHODS: Sixty-two working adults randomly selected from two different working environments in Egypt were included in the study. Participants completed a self-reported questionnaire for socio-demographic and work variables...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
Christina Bauch, Juliane Riechert, Simon Verhulst, Peter H Becker
Telomere length is a candidate biomarker of ageing and phenotypic quality, but little is known of the (physiological) causes of telomere length variation. We previously showed that individual common terns Sterna hirundo with high reproductive success had short telomeres independent of age, and this pattern was particularly strong in the longer telomeres of the within-individual telomere length distribution. To test whether this relation can be attributed to effects of reproductive effort, we investigated baseline corticosterone in relation to reproductive success (number of fledglings) and telomere length...
October 1, 2016: Molecular Ecology
Gene H Brody, Tianyi Yu, Steven R H Beach
For the past quarter century, scientists at the Center for Family Research at the University of Georgia have conducted research designed to promote understanding of normative developmental trajectories among low socioeconomic status African American children, youths, and young adults. In this paper, we describe a recent expansion of this research program using longitudinal, epidemiological studies and randomized prevention trials to test hypotheses about the origins of disease among rural African American youths...
October 3, 2016: Development and Psychopathology
Michael Rutter
Translational research focuses on innovation in healthcare settings, but this is a two-way process that may have implications for either treatment or prevention. Smoking and lung cancer and the fetal alcohol syndrome are used as examples. Experimental medicine that budges basic and clinical science often constitutes a key way forward. Areas of scientific progress and challenge are discussed in relation to drug action, social cognition, cognitive neuroscience, molecular genetics, gene-environment interaction, and epigenetics...
October 3, 2016: Development and Psychopathology
Tamara R Dietze, F F Rose, T A Moore
OBJECTIVE: Complications of prematurity may be related to dysregulation of the hypothalamic-pituitary-adrenal axis in preterm infants. Increased intrauterine exposure to cortisol may be responsible for adverse prenatal programming and subsequent dysfunction of the infant's hypothalamic-pituitary-adrenal axis. The aim of the study was to describe maternal social variables and their association with infant cortisol levels and complications of prematurity. METHODS: Preterm infants <32 weeks' gestation were recruited...
September 16, 2016: Journal of Neonatal-perinatal Medicine
Jennifer W Robinette, Susan T Charles, David M Almeida, Tara L Gruenewald
Poor neighborhoods may represent a situation of chronic stress, and may therefore be associated with health-related correlates of stress. We examined whether lower neighborhood income would relate to higher allostatic load, or physiological well-being, through psychological, affective, and behavioral pathways. Using data from the Biomarker Project of the Midlife in the United States (MIDUS) study and the 2000 Census, we demonstrated that people living in lower income neighborhoods have higher allostatic load net of individual income...
September 2016: Health & Place
Lidia López-Jiménez, Julio Blas, Alessandro Tanferna, Sonia Cabezas, Tracy Marchant, Fernando Hiraldo, Fabrizio Sergio
In long-lived animals, the challenges that threaten individual homeostasis, and the way they are dealt with, are expected to vary in an age-related manner, encompassing the progressive selection of superior phenotypes and the acquisition and improvement of key skills (e.g. foraging, breeding and fighting abilities). Since exposure to homeostatic challenges typically elevates circulating glucocorticoid (GC) levels in vertebrates (modulating the behavioural and physiological responses that mediate allostasis), we may expect concomitant age-related changes in these hormones...
August 27, 2016: Oecologia
Cristina Barboza Solís, Romain Fantin, Michelle Kelly-Irving, Cyrille Delpierre
OBJECTIVE: Our body adapts continuously to environmental challenges and stressful conditions. Allostatic load (AL) is a concept that aims to capture the overall physiological wear-and-tear of the body triggered by the repeated activation of compensatory physiological mechanisms as a response to chronic stress. Growing evidence has shown a link between AL and later health decline, morbidity and mortality. However, due to the global physiological effect captured by the AL concept, it is particularly pertinent to examine its association with subsequent health by taking a broad definition of the latter...
August 18, 2016: Psychoneuroendocrinology
Maya Vadiveloo, Josiemer Mattei
BACKGROUND: Discrimination promotes multisystem physiological dysregulation termed allostatic load, which predicts morbidity and mortality. It remains unclear whether weight-related discrimination influences allostatic load. PURPOSE: The aim of this study was to prospectively examine 10-year associations between weight discrimination, allostatic load, and its components among adults 25-75 years in the Midlife Development in the US Biomarker Substudy. METHODS: Participants with information on weight discrimination were analyzed (n=986)...
August 23, 2016: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
Christian R Salazar, Garrett Strizich, Teresa E Seeman, Carmen R Isasi, Linda C Gallo, M Larissa Avilés-Santa, Jianwen Cai, Frank J Penedo, Willian Arguelles, Anne E Sanders, Richard B Lipton, Robert C Kaplan
Allostatic load (AL), an index of biological "wear and tear" on the body from cumulative exposure to stress, has been little studied in US Hispanics/Latinos. We investigated AL accumulation patterns by age, sex, and nativity in the Hispanic Community Health Study/Study of Latinos. We studied 15,830 Hispanic/Latinos of Mexican, Cuban, Dominican, Puerto Rican, Central and South American descent aged 18-74 years, 77% of whom were foreign-born. Consistent with the conceptualization of AL, we developed an index based upon 16 physiological markers that spanned the cardiometabolic, parasympathetic, and inflammatory systems...
December 2016: SSM—Population Health
Cristina Barboza Solís, Romain Fantin, Raphaële Castagné, Thierry Lang, Cyrille Delpierre, Michelle Kelly-Irving
Understanding how human environments affect our health by "getting under the skin" and penetrating the cells, organs and physiological systems of our bodies is a key tenet in public health research. Here, we examine the idea that early life socioeconomic position (SEP) can be biologically embodied, potentially leading to the production of health inequalities across population groups. Allostatic load (AL), a composite measure of overall physiological wear-and-tear, could allow for a better understanding of the potential biological pathways playing a role in the construction of the social gradient in adult health...
September 2016: Social Science & Medicine
Nicole Wiggert, Frank H Wilhelm, Motohiro Nakajima, Mustafa al'Absi
BACKGROUND AND OBJECTIVES: Both chronic smoking and trait anxiety have been associated with dysregulations in psychobiological stress response systems. However, these factors have not been studied in conjunction. We expected trait anxiety and smoking status to attenuate stress reactivity. Furthermore, we expected an allostatic load effect resulting in particularly attenuated stress reactivity in high-anxious smokers. In addition, high-anxious smokers were expected to exhibit increased urges to smoke in response to stress...
October 14, 2016: Substance Use & Misuse
Daniel Mauss, Marc N Jarczok, Joachim E Fischer
According to the World Health Organization stress in the workplace is becoming a major challenge of employers worldwide. While perceived stress levels can be assessed by questionnaires there is growing evidence that stress-related wear and tear of our body can be measured by the Allostatic Load Index (ALI). In a sample of 12,477 German industrial employees (19.6% female, 18-65 years) self-rated stress was explored by the effort-reward imbalance (ERI) questionnaire. A voluntary health check included biomarkers such as diastolic blood pressure, waist circumference, glycosylated hemoglobin, low-density lipoprotein, and heart rate variability...
August 2, 2016: Stress: the International Journal on the Biology of Stress
Bruce S McEwen, Craig A McEwen
To be useful, the concept of stress needs to be defined in biological terms linked to a broader framework of allostasis and its role in the adaptation of brain and body to positive and negative life experiences. A clear biological framework helps connect and organize animal and human research on stress. In particular, the concepts of "toxic stress" and "allostatic load and overload" highlight those experiences and situations that, as Kagan says, "compromise an organism's health and capacity to cope with daily challenges" (p...
July 2016: Perspectives on Psychological Science: a Journal of the Association for Psychological Science
Sophie Reijman, Marian J Bakermans-Kranenburg, Regina Hiraoka, Julie L Crouch, Joel S Milner, Lenneke R A Alink, Marinus H van IJzendoorn
We reviewed and meta-analyzed 10 studies (N = 492) that examined the association between (risk for) child maltreatment perpetration and basal autonomic activity, and 10 studies (N = 471) that examined the association between (risk for) child maltreatment and autonomic stress reactivity. We hypothesized that maltreating parents/at-risk adults would show higher basal levels of heart rate (HR) and skin conductance (SC) and lower levels of HR variability (HRV) and would show greater HR and SC stress reactivity, but blunted HRV reactivity...
July 26, 2016: Child Maltreatment
Breno Satler Diniz, Chien-Wei Lin, Etienne Sibille, George Tseng, Francis Lotrich, Howard J Aizenstein, Charles F Reynolds, Meryl A Butters
There is scarce information about the pathophysiological processes underlying Late-Life Depression (LLD). We aimed to determine the neurobiological abnormalities related to LLD through a multi-modal biomarker approach combining a large, unbiased peripheral proteomic panel and structural brain imaging. We examined data from 44 LLD and 31 control participants. Plasma proteomic analysis was performed using a multiplex immunoassay. We evaluated the differential protein expression between groups with random intercept models...
November 2016: Journal of Psychiatric Research
Theresa M Beckie, Allyson Duffy, Maureen W Groer
BACKGROUND: Allostatic load (AL) is a novel perspective for examining the damaging effects of stress on health and disease. Women veterans represent an understudied yet vulnerable subgroup of women with increased reports of traumatic stressors across their lifespan. AL has not been examined in this group. This study hypothesized that reports of sexual assault in childhood, civilian life, or in the military by women veterans was associated with AL and selected psychosocial measures. We also hypothesized that AL scores are positively associated with psychosocial characteristics...
September 2016: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
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