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Allostatic load

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https://www.readbyqxmd.com/read/29352998/two-weeks-of-variable-stress-increases-gamma-h2ax-levels-in-the-mouse-bed-nucleus-of-the-stria-terminalis
#1
Brendan D Hare, Tina M Thornton, Mercedes Rincon, Borivoj Golijanin, S Bradley King, Diane M Jaworski, William A Falls
Recent reports demonstrate that DNA damage is induced, and rapidly repaired, in circuits activated by experience. Moreover, stress hormones are known to slow DNA repair, suggesting that prolonged stress may result in persistent DNA damage. Prolonged stress is known to negatively impact physical and mental health; however, DNA damage as a factor in stress pathology has only begun to be explored. Histone H2A-X phosphorylated at serine 139 (γH2AX) is a marker of DNA double strand breaks (DSB), a type of damage that may lead to cell death if unrepaired...
January 15, 2018: Neuroscience
https://www.readbyqxmd.com/read/29349273/the-contribution-of-three-dimensions-of-allostatic-load-to-racial-ethnic-disparities-in-poor-fair-self-rated-health
#2
Alexis R Santos-Lozada, Jonathan Daw
Objective: This study evaluates whether different dimensions of physiological dysregulation, modeled individually rather than additively mediate racial/ethnic disparities in self-reported health. Methods: Using data from the National Health and Nutrition Examination Survey (2005-2010) and the Karlson, Hold, and Breen (KHB) mediation model, this paper explores what operationalization of biomarker data most strongly mediate racial/ethnic disparities in poor/fair self-rated health (SRH) among adults in the United States, net of demographic, socioeconomic, behavioral, and medication controls...
April 2018: SSM—Population Health
https://www.readbyqxmd.com/read/29338677/vitamin-b-6-and-depressive-symptomatology-over-time-in-older-latino-adults
#3
Sandra P Arévalo, Tammy M Scott, Luis M Falcón, Katherine L Tucker
BACKGROUND: Low vitamin B-6 status has been linked to depressive symptomatology. We examined the longitudinal association of vitamin B-6 status with depressive symptomatology across 3-time points over ∼5-7 years in a cohort of older Hispanic adults. METHODS: We used two-level hierarchical linear regression models for continuous outcomes. Vitamin B-6 status was associated with depressive symptomatology across these time points. RESULTS: Plasma pyridoxyl-5-phosphate (PLP) concentration, a time-varying predictor, was significantly associated with depressive symptomatology...
January 16, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29335889/comparison-of-gray-matter-volume-between-migraine-and-strict-criteria-tension-type-headache
#4
Wei-Ta Chen, Kun-Hsien Chou, Pei-Lin Lee, Fu-Jung Hsiao, David M Niddam, Kuan-Lin Lai, Jong-Ling Fuh, Ching-Po Lin, Shuu-Jiun Wang
BACKGROUND: Despite evidently distinct symptoms, tension-type headache (TTH) and migraine are highly comorbid and exhibit many similarities in clinical practice. The purpose of this study was to investigate whether both types of headaches are similar in brain morphology. METHODS: Consecutive patients with TTH and age- and sex-matched patients with migraine and healthy controls were enrolled for brain magnetic resonance imaging examination. Patients with TTH were excluded if they reported any headache features or associated symptoms of migraine...
January 15, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/29332629/psychobiological-stress-in-vital-exhaustion-findings-from-the-men-stress-40-study
#5
Emilou Noser, Susanne Fischer, Jessica Ruppen, Ulrike Ehlert
OBJECTIVE: Despite the increased risk for cardiovascular morbidity associated with vital exhaustion (VE), the underlying pathophysiological mechanisms remain unclear. Allostatic load may constitute the missing link between VE and cardiovascular diseases. The aim of the present study was to investigate whether men with different degrees of VE would differ in terms of allostatic load, chronic stress, and social support. METHODS: The Men Stress 40+ study sample consisted of N=121 apparently healthy men aged 40 to 75years...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29276735/circuit-and-synaptic-mechanisms-of-repeated-stress-perspectives-from-differing-contexts-duration-and-development
#6
REVIEW
Kevin G Bath, Scott J Russo, Kristen E Pleil, Eric S Wohleb, Ronald S Duman, Jason J Radley
The current review is meant to synthesize research presented as part of a symposium at the 2016 Neurobiology of Stress workshop in Irvine California. The focus of the symposium was "Stress and the Synapse: New Concepts and Methods" and featured the work of several junior investigators. The presentations focused on the impact of various forms of stress (altered maternal care, binge alcohol drinking, chronic social defeat, and chronic unpredictable stress) on synaptic function, neurodevelopment, and behavioral outcomes...
December 2017: Neurobiology of Stress
https://www.readbyqxmd.com/read/29235143/allostatic-load-but-not-medical-burden-predicts-memory-performance-in-late-life-bipolar-disorder
#7
REVIEW
Sophie R Vaccarino, Tarek K Rajji, Ariel G Gildengers, Sarah E S Waters, Meryl A Butters, Mahesh Menon, Daniel M Blumberger, Aristotle N Voineskos, Dielle Miranda, Benoit H Mulsant
OBJECTIVE: Older patients with bipolar disorder (BD) present with variable degrees of cognitive impairment. Over time, stress, mood episodes, and comorbidities increase the body's allostatic load. We assessed the extent to which allostatic load vs more traditional measures of medical burden account for the heterogeneity in cognition in this population. METHODS: Thirty-five older euthymic patients with BD and 30 age-equated, gender-equated, and education-equated comparison participants were administered a comprehensive assessment including a neuropsychological battery, and 9 physiological measures to determine allostatic load...
December 13, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29229436/a-longitudinal-analysis-of-allostatic-load-among-a-multi-ethnic-sample-of-midlife-women-findings-from-the-study-of-women-s-health-across-the-nation
#8
Laura Chyu, Dawn M Upchurch
OBJECTIVES: We examined longitudinal patterns and sociodemographic correlates of allostatic load (AL), a measure of cumulative biological risk and aging, in a sample of midlife women consisting of non-Hispanic White, African American, Chinese, and Japanese women. METHODS: Longitudinal cohort data from the Study of Women's Health Across the Nation were used to examine AL patterns in midlife women ages 42-53 (n = 1,932). AL measures were created using 10 biomarkers representing cardiovascular, inflammatory, neuroendocrine, and metabolic system functioning...
December 8, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29226194/childhood-socioeconomic-status-and-stress-in-late-adulthood-a-longitudinal-approach-to-measuring-allostatic-load
#9
Katelyn Y Graves, Alexandra C H Nowakowski
Objectives: This study examines how the effects of childhood socioeconomic status (SES) may carry on into late adulthood. Methods: We examine how childhood SES affects both perceived stress and allostatic load, which is a cumulative measure of the body's biologic response to chronic stress. We use the National Social Life, Health, and Aging Project, Waves 1 and 2, and suggest a novel method of incorporating a longitudinal allostatic load measure. Results: Individuals who grew up in low SES households have higher allostatic load scores in late adulthood, and this association is mediated mostly by educational attainment...
2017: Global Pediatric Health
https://www.readbyqxmd.com/read/29215457/associations-of-positive-affect-and-negative-affect-with-allostatic-load-a-lifelines-cohort-study
#10
Hendrika M Schenk, Bertus F Jeronimus, Lian van der Krieke, Elisabeth H Bos, Peter de Jonge, Judith G M Rosmalen
OBJECTIVE: Allostatic load (AL) reflects the deteriorating influences of stress on the body, and comprises a selection of biological markers. AL is associated with negative life events, stress, and negative affect (NA), as well as poor health outcomes. However, whether AL is also associated with positive affect (PA) is not clear. The present study therefore explores the association between PA and AL, accounting for age, sex, NA, and health behaviors. METHODS: Data of 45,225 individuals from the first wave of the multi-disciplinary prospective population-based cohort study Lifelines were used...
December 5, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29167051/discrimination-and-anger-control-as-pathways-linking-socioeconomic-disadvantage-to-allostatic-load-in-midlife
#11
Samuele Zilioli, Ledina Imami, Anthony D Ong, Mark A Lumley, Tara Gruenewald
OBJECTIVE: Recent evidence suggests that experiences of discrimination contribute to socioeconomic status health disparities. The current study examined if the experience and regulation of anger-an expected emotional response to discrimination-serves as an explanatory factor for the previously documented links between socioeconomic disadvantage (SED), discrimination, and allostatic load. METHODS: Data were drawn from the second wave of the Midlife in the United States (MIDUS) study and included 909 adults who participated in the biomarkers subproject...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29167046/changes-in-allostatic-load-during-workplace-reorganization
#12
Rikke Hinge Carlsson, Åse Marie Hansen, Martin Lindhardt Nielsen, Morten Blønd, Bo Netterstrøm
OBJECTIVE: Allostatic Load (AL) represents the strain on the body produced by repeated physiologic or allostatic responses activated during stressful situations. Several cross-sectional studies have found empirical substantiation for the relationship between impaired psychosocial work environment and high AL. The aim of this longitudinal study is to investigate changes in AL during workplace reorganization that has been shown to cause impaired psychosocial work environment. Moreover, we aim to investigate the association between changes in AL and changes in psychosocial work environment (job strain, effort-reward imbalance) and psychological distress (stress symptoms and perceived stress)...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29166248/neighborhood-disadvantage-and-allostatic-load-in-african-american-women-at-risk-for-obesity-related-diseases
#13
Marissa Tan, Abdullah Mamun, Heather Kitzman, Surendra Reddy Mandapati, Leilani Dodgen
INTRODUCTION: African American women have higher rates of obesity and related chronic disease than other demographic groups. The poorer health of African American women compared with other groups may be explained by allostatic load, or cumulative physiologic stress, due to chronic socioeconomic disadvantage. The objective of this study was to evaluate neighborhood and individual factors contributing to allostatic load in African American women at risk for obesity-related diseases. METHODS: This study evaluated the relationship of allostatic load with neighborhood disadvantage, individual socioeconomic determinants, and synergism between neighborhood and socioeconomic disadvantage, along with health behaviors and other factors as mediators in African American women...
November 22, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29166164/a-physiological-signature-of-the-cost-of-reproduction-associated-with-parental-care
#14
Melinda A Fowler, Tony D Williams
Costs of reproduction are an integral and long-standing component of life-history theory, but we still know relatively little about the specific physiological mechanisms underlying these trade-offs. We experimentally manipulated workload during parental care in female European starlings (Sturnus vulgaris) using attachment of radios and/or wing clipping and assessed measures of workload, current breeding productivity, future fecundity, and survival (local return rate) in relation to treatment. Females with wing clipping and radio attachment paid a clear cost of reproduction compared with all other treatment groups: they had lower future fecundity and lower return rates despite having lower current breeding productivity...
December 2017: American Naturalist
https://www.readbyqxmd.com/read/29162191/childhood-adversity-moderates-the-influence-of-proximal-episodic-stress-on-the-cortisol-awakening-response-and-depressive-symptoms-in-adolescents
#15
Lisa R Starr, Kimberly Dienes, Catherine B Stroud, Zoey A Shaw, Y Irina Li, Fanny Mlawer, Meghan Huang
Childhood adversity (CA) is known to predict sensitization to proximal stressors. Researchers have suggested that disruptions in hypothalamus-pituitary-adrenal axis functioning may be a biological mechanism. If so, CA may predict altered associations between proximal life stress and markers of cortisol secretion. We examined whether CA moderates associations between recent episodic stress and (a) the cortisol awakening response (CAR), and (b) depressive symptoms, in 241 adolescents aged 14-17 years (cortisol n = 196)...
December 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/29108934/cardiovascular-control-is-associated-with-pair-bond-success-in-male-prairie-voles
#16
Robert Lewis, Brek Wilkins, Bruce Benjamin, J Thomas Curtis
Social support structures reduce mortality and morbidity in humans, but the mechanisms underlying these reductions are not fully understood. The prevailing hypothesis is that social support buffers stress and reduces allostatic load, thereby increasing longevity. However, the possibility that affiliative social interactions confer health benefits independent of stress buffering is understudied. We examined autonomic function in prairie voles - arguably the premier species for modeling human social affiliation - to assess the possibility that the formation of strong social bonds alters autonomic function and contributes to health benefits...
October 2, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29107462/each-meal-matters-in-the-exposome-biological-and-community-considerations-in-fast-food-socioeconomic-associations
#17
Susan L Prescott, Alan C Logan
Advances in omics and microbiome technology have transformed the ways in which the biological consequences of life in the 'ecological theatre' can be visualized. Exposome science examines the total accumulated environmental exposures (both detrimental and beneficial) as a means to understand the response of the 'total organism to the total environment' over time. The repetitive stimulation of compensatory physiological responses (immune, cardiovascular, neuroendocrine) in response to stress - including sources of stress highly relevant to socioeconomic disadvantage - may lead to metabolic dysregulation and cellular damage, ultimately influencing behavior and disease...
November 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29082305/explaining-racial-and-ethnic-inequalities-in-postpartum-allostatic-load-results-from-a-multisite-study-of-low-to-middle-income-woment
#18
Patricia O'Campo, Christine Dunkel Schetter, Christine M Guardino, Maxine Reed Vance, Calvin J Hobel, Sharon Landesman Ramey, Madeleine U Shalowitz
BACKGROUND: Racial and ethnic inequalities in women's health are widely documented, but not for the postpartum period, and few studies examine whether neighborhood, psychosocial, and biological factors explain these gaps in women's health. METHODS: Using prospective longitudinal data collected from 1766 low to middle income women between 2008 and 2012 by the Community Child Health Network (CCHN), we tested the extent to which adjustment for neighborhood, economic, psychological, and medical conditions following a birth explained differences between African American, Latina, and White women in an indicator of physiological dysregulation allostatic load (AL), at one year postpartum as measured by 10 biomarkers: Body Mass Index, Waist Hip Ratio, systolic and diastolic blood pressure, high sensitivity C-reactive protein, Hemoglobin A1c, high-density lipoprotein and cholesterol ratio, and diurnal cortisol...
December 2016: SSM—Population Health
https://www.readbyqxmd.com/read/29078038/influence-of-supraphysiological-cortisol-manipulation-on-predator-avoidance-behaviours-and-physiological-responses-to-a-predation-threat-in-a-wild-marine-teleost-fish
#19
Michael J Lawrence, Erika J Eliason, Jacob W Brownscombe, Kathleen M Gilmour, John W Mandelman, Lee F G Gutowsky, Steven J Cooke
The stress axis in teleost fish attempts to maintain internal homeostasis in the face of allostatic loading. However, stress axis induction has been associated with a higher predation rate in fish. To date, the physiological and behavioural factors associated with this outcome are poorly understood. The purpose of the present study was to investigate the impact of experimental cortisol elevation on anti-predator behaviour and physiological responses to predator presence. We hypothesized that semi-chronic cortisol elevation would increase susceptibility to predation by increasing stress-induced risk taking behaviours...
October 27, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/29062338/allostatic-load-and-heart-rate-variability-as-health-risk-indicators
#20
Margaretha Viljoen, Nicolaas Claassen
BACKGROUND: Uncertainty often exists about the comparability of results obtained by different health risk indicator systems. OBJECTIVES: To compare two health risk indicator systems, i.e, allostatic load and heart rate variability (HRV). Additionally, to investigate the feasibility of inclusion of HRV indicators into allostatic load assessments and which HRV indicators are best to introduce. METHODS: Allostatic loads were calculated based on blood pressure, waist-to-hip ratio, BMI, cholesterol, HDL-C, LDL-C, CRP, albumin, glycosylated haemoglobin, blood glucose and cortisol excretion...
June 2017: African Health Sciences
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