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Allostatic load

Marta Gòdia, Grace Swanson, Stephen A Krawetz
Having been debated for many years, the presence and role of spermatozoal RNAs is resolving, and their contribution to development is now appreciated. Data from different species continues to show that sperm contain a complex suite of coding and non-coding RNAs that play a role in an individual's life course. Mature sperm RNAs provide a retrospective of spermatogenesis, with their presence and abundance reflecting sperm maturation, fertility potential, and the paternal contribution to the developmental path the offspring may follow...
March 4, 2018: Biology of Reproduction
Constanze Eib, Claudia Bernhard-Oettel, Linda L Magnusson Hanson, Constanze Leineweber
Organizational justice perceptions are considered a predictor of health and well-being. To date, empirical evidence about whether organizational justice perceptions predict health or health predicts organizational justice perceptions is mixed. Furthermore, the processes underlying these relationships are largely unknown. In this article, we study whether bidirectional relationships can be explained by 2 different mediation mechanisms. First, based on the allostatic load model, we suggest that the relationships between organizational justice perceptions and different health indicators are mediated through mental preoccupation with work...
March 5, 2018: Journal of Occupational Health Psychology
Allyson R Duffy, Donna L Schminkey, Maureen W Groer, Melissa Shelton, Samia Dutra
OBJECTIVE: To evaluate relationships between hair cortisol levels and perceived stress in mothers who deliver preterm and term. We hypothesized that the rate of change in cortisol levels would be greater in the preterm delivery group. METHODS: This preliminary study compared hair cortisol levels and Perceived Stress Scale (PSS) scores in predominately Caucasian mothers who delivered preterm ( n = 22) and term ( n = 30). We collected PSS and hair samples of ≥10 cm in length from mothers after delivery...
January 1, 2018: Biological Research for Nursing
Raquel González-Ochoa, Elly N Sánchez-Rodríguez, Anahi Chavarría, Gabriel Gutiérrez-Ospina, Tania Romo-González
Gestational stress is believed to increase the risk of pregnancy failure and perinatal and adult morbidity and mortality in both the mother and her child or children. However, some contradictions might arise from methodological issues or even from differences in the philosophical grounds that guide the studies on gestational stress. Biased perspectives could lead us to use and/or design inadequate/incomplete panels of biochemical determinations and/or psychological instruments to diagnose it accurately during pregnancy, a psychoneuroimmune-endocrine state in which allostatic loads may be significant...
2018: Journal of Pregnancy
Bobby Habig, Meredith M Doellman, Kourtney Woods, Jonathan Olansen, Elizabeth A Archie
Social status is an important predictor of parasite risk in vertebrates. To date, general frameworks to explain status-related variation in parasitism have remained elusive. In this meta-analysis, we evaluated five hypotheses proposed to explain status-related variation in parasitism in male and female vertebrates by leveraging variation in hierarchy type, mating system, parasite transmission mode, and allostatic load to test associated predictions. Our meta-analyses span 66 analyses (26 studies) of male vertebrates (two orders and five classes), and 62 analyses (13 studies) of female vertebrates (four vertebrate orders)...
February 26, 2018: Scientific Reports
Raphaële Castagné, Valérie Garès, Maryam Karimi, Marc Chadeau-Hyam, Paolo Vineis, Cyrille Delpierre, Michelle Kelly-Irving
The concept of allostatic load (AL) refers to the idea of a global physiological 'wear and tear' resulting from the adaptation to the environment through the stress response systems over the life span. The link between socioeconomic position (SEP) and mortality has now been established, and there is evidence that AL may capture the link between SEP and mortality. In order to quantitatively assess the role of AL on mortality, we use data from the 1958 British birth cohort including eleven year mortality in 8,113 adults...
February 23, 2018: European Journal of Epidemiology
Rosa Sze Man Wong, Esther Yee Tak Yu, Vivian Yawei Guo, Eric Yuk-Fai Wan, Weng-Yee Chin, Carlos King Ho Wong, Colman Siu Cheung Fung, Keith Tsz Suen Tung, Wilfred Hing-Sang Wong, Patrick Ip, Agnes Fung Yee Tiwari, Cindy Lo Kuen Lam
INTRODUCTION: Chronic stress has adverse effects on health. Adults and children from low-income families are subject to multiple sources of stress. Existing literature about economic hardship mostly focuses on either adults or children but not both. Moreover, there is limited knowledge on the relationship between parental generalised stress and child health problems. This study aims to explore the bidirectional relationship between parental stress and child health in Chinese low-income families and to identify other modifiable factors influencing this relationship...
February 22, 2018: BMJ Open
Gyu Ri Kim, Sun Ha Jee, Hynek Pikhart
BACKGROUND: The relationship between socioeconomic status and mortality has been well established; however, the extent to which biological factors mediate this relationship is less clear, and empirical evidence from non-Western settings is limited. Allostasis, a cumulative measure of physiological dysregulation, has been proposed as the underlying mechanism linking socioeconomic status to adverse health outcomes. The current study aimed to ascertain the contribution of allostatic load (AL) and health behaviours to socioeconomic inequalities in mortality among Korean adults...
February 19, 2018: Journal of Epidemiology and Community Health
Zander Crook, Tom Booth, Simon R Cox, Janie Corley, Dominika Dykiert, Paul Redmond, Alison Pattie, Adele M Taylor, Sarah E Harris, John M Starr, Ian J Deary
OBJECTIVES: In this replication-and-extension study, we tested whether depressive symptoms, neuroticism, and allostatic load (multisystem physiological dysregulation) were related to lower baseline cognitive ability and greater subsequent cognitive decline in older adults, and whether these relationships were moderated by the E4 allele of the apolipoprotein E (APOE) gene. We also tested whether allostatic load mediated the relationships between neuroticism and cognitive outcomes. METHODS: We used data from the Lothian Birth Cohort 1936 (n at Waves 1-3: 1,028 [M age = 69...
2018: PloS One
Ari J Elliot, Christopher J Mooney, Frank J Infurna, Benjamin P Chapman
Mechanisms underlying prospective associations of perceived control with frailty and other health outcomes are not well understood. In the present study we used 3 waves of data from the Health and Retirement Study (N = 2,127) to test potential psychological and biological pathways linking perceived control with frailty over an 8-year period, and whether 4-year change in control predicts frailty independent of initial control. Lower odds of increasing frailty were associated with higher initial levels of perceived control (odds ratio [OR] = ...
February 15, 2018: Psychology and Aging
Maximus Berger, Robert-Paul Juster, Sabine Westphal, G Paul Amminger, Bernhard Bogerts, Kolja Schiltz, Sabine Bahn, Johann Steiner, Zoltan Sarnyai
Current pathophysiological models of schizophrenia suggest that stress contributes to the etiology and trajectory of the disorder. We investigated if allostatic load (AL), an integrative index of neuroendocrine, immune and metabolic dysregulation in response to chronic stress, is elevated in patients with schizophrenia (SCZ) and first-episode psychosis (FEP) and related to psychotic symptoms and social and occupational functioning. Additionally, we assessed the temporal dynamics of AL in response to treatment with second-generation antipsychotics...
February 5, 2018: Psychoneuroendocrinology
Andrew W Manigault, Alex Woody, Peggy M Zoccola, Sally S Dickerson
BACKGROUND: Mindfulness, or the practice of observing present moment experiences with acceptance, is thought to improve health at least partially by limiting hypothalamic-pituitary-adrenal (HPA) axis over-responsiveness during episodes of acute stress. However, models of allostatic load suggest that HPA axis under-responsiveness can also be detrimental to health, and the relationship between mindfulness and cortisol under-responsiveness has yet to be examined. The present study therefore aimed to address this knowledge gap, and to revisit the relationship between mindfulness and acute cortisol response magnitude while excluding (or statistically controlling for) individuals displaying HPA axis under-responsiveness...
January 31, 2018: Psychoneuroendocrinology
Erik J Rodriquez, Jennifer Livaudais-Toman, Steven E Gregorich, James S Jackson, Anna M Nápoles, Eliseo J Pérez-Stable
Unhealthy behaviors may modify relationships between chronic stress and depression among diverse older adults. We analyzed nationally representative cross-sectional data from participants aged 40-79 years of the 2005-2012 National Health and Nutrition Examination Survey. Unhealthy behaviors included current smoking, excessive/binge drinking, insufficient physical activity, and fair/poor diet. Allostatic load was defined by 10 biomarkers indicating the cumulative physiologic burden of stress. Depressive disorder was assessed using the Patient Health Questionnaire...
February 5, 2018: Preventive Medicine
Lisa M Christian, Jennifer M Kowalsky, Amanda M Mitchell, Kyle Porter
BACKGROUND: Postpartum is a period of unique psychosocial stress characterized by sleep disturbance, risk for depressed mood, and heightened parenting stress. However, data on effects of these exposures on inflammatory immune function are limited. METHODS: This study examined associations among sleep, psychosocial stress (i.e., parenting stress, general perceived stress), mood (i.e., depressive symptoms), serum cytokine levels, and LPS-stimulated proinflammatory cytokine production among 69 women (32 African American, 37 White) assessed at 7-10weeks postpartum...
March 15, 2018: Journal of Neuroimmunology
Martin Picard, Bruce S McEwen
OBJECTIVE: Mitochondria are multifunctional life-sustaining organelles that represent a potential intersection point between psychosocial experiences and biological stress responses. This article provides a systematic review of the effects of psychological stress on mitochondrial structure and function. METHODS: A systematic review of the literature investigating the effects of psychological stress on mitochondrial function was conducted. The review focused on experimentally controlled studies allowing us to draw causal inference about the effect of induced psychological stress on mitochondria...
February 2018: Psychosomatic Medicine
Martin Picard, Bruce S McEwen
BACKGROUND: The integration of biological, psychological, and social factors in medicine has benefited from increasingly precise stress response biomarkers. Mitochondria, a subcellular organelle with its own genome, produce the energy required for life and generate signals that enable stress adaptation. An emerging concept proposes that mitochondria sense, integrate, and transduce psychosocial and behavioral factors into cellular and molecular modifications. Mitochondrial signaling might in turn contribute to the biological embedding of psychological states...
February 2018: Psychosomatic Medicine
Ivan Neil Gomez, Cynthia Yy Lai, Trevor Wk Yung, Chetwyn Ch Chan, Hector Wh Tsang
BACKGROUND: Migration is a worldwide phenomenon in recent times. Recently, documented studies suggest that the change in environments involved in migration may have an influence on children's allostatic load related to health and well-being. OBJECTIVE: The aim of this review is to systematically search the extant literature and critically examine the evidence on how migration affects allostatic load in children and describe the relevant methods in measuring allostatic load...
January 30, 2018: JMIR Research Protocols
José Ignacio Cuitún Coronado, Tarani Chandola, Andrew Steptoe
Although associations between work stressors and stress-related biomarkers have been reported in cross-sectional studies, the use of single time measurements of work stressors could be one of the reasons for inconsistent associations. This study examines whether repeated reports of work stress towards the end of the working career predicts allostatic load, a measure of chronic stress related physiological processes. Data from waves 2 to 6 of the English Longitudinal Study of Ageing (ELSA) were analysed, with a main analytical sample of 2663 older adults (aged 50+) who had at least one measurement of effort-reward imbalance between waves 2-6 and a measurement of allostatic load at wave 6...
January 24, 2018: International Journal of Environmental Research and Public Health
Ganga S Bey, Molly E Waring, Bill M Jesdale, Sharina D Person
Chronic stress stemming from social inequity has long been recognized as a risk factor for poor physical and psychological health, yet challenges remain in uncovering the mechanisms through which such exposures affect health outcomes and lead to racial and gender health disparities. Examination of sociocultural influences on group identity, coping, and the expression of stress may yield relevant insight into potential pathways of inequity's effect on risk for chronic disease. The objective of this study was to examine the relationship between chronic stress as measured by allostatic load (AL) and depression by gendered race group...
January 22, 2018: American Journal of Orthopsychiatry
Brendan D Hare, Tina M Thornton, Mercedes Rincon, Borivoj Golijanin, S Bradley King, Diane M Jaworski, William A Falls
Recent reports demonstrate that DNA damage is induced, and rapidly repaired, in circuits activated by experience. Moreover, stress hormones are known to slow DNA repair, suggesting that prolonged stress may result in persistent DNA damage. Prolonged stress is known to negatively impact physical and mental health; however, DNA damage as a factor in stress pathology has only begun to be explored. Histone H2A-X phosphorylated at serine 139 (γH2AX) is a marker of DNA double strand breaks (DSB), a type of damage that may lead to cell death if unrepaired...
January 15, 2018: Neuroscience
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