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Allostatic load

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https://www.readbyqxmd.com/read/28926525/effect-of-a-mentor-based-supportive-expressive-program-be-resilient-to-breast-cancer-on-survival-in-metastatic-breast-cancer-a-randomised-controlled-intervention-trial
#1
Zeng Jie Ye, Hong Zhong Qiu, Mu Zi Liang, Mei Ling Liu, Peng Fei Li, Peng Chen, Zhe Sun, Yuan Liang Yu, Shu Ni Wang, Zhang Zhang, Kun Lun Liao, Cai Fen Peng, Hui Huang, Guang Yun Hu, Yun Fei Zhu, Zhen Zeng, Qu Hu, Jing Jing Zhao
BACKGROUND: Because of medical advances, metastatic breast cancer (MBC) is now viewed as a chronic disease, rather than an imminent death sentence. Helping women live with this disease requires more than a medical approach to symptoms. Thus, a mentor-based and supportive-expressive program 'Be Resilient to Breast Cancer' (BRBC) was designed to help Chinese women with MBC enhance their resilience levels, biopsychosocial functions, and potentially extend their life span. METHODS: A total of 226 women with MBC were randomly assigned, in a 1 : 1 ratio, to an intervention group (IG) that participated in BRBC or to a control group (CG) that received no intervention...
September 19, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28918418/new-aspects-in-the-pathomechanism-of-diseases-of-civilization-particularly-psychosomatic-disorders-part-1-theoretical-background-of-a-hypothesis
#2
Andras Sikter, Zoltan Rihmer, Roberto de Guevara
The stress defence-cascade is mostly not biphasic as Cannon thought, the sympathicotonic stress response is preceded by a vagotonic phase called freeze response. Alteration of the carbon dioxide level plays an important role during defence-cascade as its changes interfere with stress hormones, e.g. with catecholamines, thus affecting the degree of arousal. In case of humans, learned behaviour dominates instead of instinctive, so the fight-or-flight often lags; the consequence can be persistent hypocapnia or hypercapnia...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28918243/homeostatic-systems-biocybernetics-and-autonomic-neuroscience
#3
REVIEW
David S Goldstein, Irwin J Kopin
In this review we describe a series of major concepts introduced during the past 150years that have contributed to our current understanding about how physiological processes required for well-being and survival are regulated. One can theorize that hierarchical networks involving input-output relationships continuously orchestrate and learn adaptive patterns of observable behaviors, cognition, memory, mood, and autonomic systems. Taken together, these networks function as "good regulators" determining levels of internal variables and act as if there were homeostatic comparators ("homeostats")...
September 5, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28880949/maternal-hypothalamic-pituitary-adrenal-axis-response-to-foraging-uncertainty-a-model-of-individual-vs-social-allostasis-and-the-superorganism-hypothesis
#4
Jeremy D Coplan, Nishant K Gupta, Asif Karim, Anna Rozenboym, Eric L P Smith, John G Kral, Leonard A Rosenblum
INTRODUCTION: Food insecurity is a major global contributor to developmental origins of adult disease. The allostatic load of maternal food uncertainty from variable foraging demand (VFD) activates corticotropin-releasing factor (CRF) without eliciting hypothalamic-pituitary-adrenal (HPA) activation measured on a group level. Individual homeostatic adaptations of the HPA axis may subserve second-order homeostasis, a process we provisionally term "social allostasis." We postulate that maternal food insecurity induces a "superorganism" state through coordination of individual HPA axis response...
2017: PloS One
https://www.readbyqxmd.com/read/28880686/preliminary-evidence-of-attenuated-blood-pressure-reactivity-to-acute-stress-in-adults-following-a-recent-marital-separation
#5
Austin M Grinberg, Karey L O'Hara, Dave A Sbarra
OBJECTIVE: This study explores cardiovascular reactivity during an acute-stress task in a sample of recently separated adults. DESIGN: In a cross-sectional design, we examined the association between adults' subjective separation-related distress and changes in heart rate and blood pressure across the acute-stress laboratory paradigm in a sample of 133 (n = 49 men) recently separated adults. MAIN OUTCOME MEASURES: Heart rate (HR) and Blood pressure (BP) were recorded across a resting baseline period, a math stressor task, and a recovery period...
September 7, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28870356/the-childhood-roots-of-cardiovascular-disease-disparities
#6
REVIEW
Donald A Barr
A recent national review of the social determinants of cardiovascular disease (CVD) underscored the growing recognition that poor socioeconomic conditions early in life place children at higher risk for CVD as adults. There is growing evidence that chronic elevation of allostatic load as a consequence of high levels of early childhood stress can trigger early atherosclerotic changes in children independently of behaviors. Elevated levels of circulating cortisol have been documented in children as young as 4 years who were raised in highly stressful circumstances...
September 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28862266/genomic-and-epigenomic-mechanisms-of-glucocorticoids-in-the-brain
#7
REVIEW
Jason D Gray, Joshua F Kogan, Jordan Marrocco, Bruce S McEwen
Following the discovery of glucocorticoid receptors in the hippocampus and other brain regions, research has focused on understanding the effects of glucocorticoids in the brain and their role in regulating emotion and cognition. Glucocorticoids are essential for adaptation to stressors (allostasis) and in maladaptation resulting from allostatic load and overload. Allostatic overload, which can occur during chronic stress, can reshape the hypothalamic-pituitary-adrenal axis through epigenetic modification of genes in the hippocampus, hypothalamus and other stress-responsive brain regions...
September 1, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28856337/neurobiological-and-systemic-effects-of-chronic-stress
#8
Bruce S McEwen
The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor, which promote adaptation ("allostasis") but also contribute to pathophysiology ("allostatic load/overload") when overused and dysregulated. The adult as well as developing brain possesses a remarkable ability to show structural and functional plasticity in response to stressful and other experiences, including neuronal replacement, dendritic remodeling and synapse turnover...
January 2017: Chronic stress
https://www.readbyqxmd.com/read/28856219/circulating-markers-of-ageing-and-allostatic-load-a-slow-train-coming
#9
Paul G Shiels, Peter Stenvinkel, Jeroen P Kooman, Dagmara McGuinness
Dealing with the growing burden of age-related morbidities is one of the greatest challenges facing modern society. How we age across the lifecourse and how psychosocial and lifestyle factors interplay with the biology of ageing remains to be fully elucidated. Sensitive and specific biomarkers with which to interrogate the biology of the ageing process are sparse. Recent evidence suggests that non-coding RNAs are key determinants of such processes and that these can be used as potential circulatory bio-markers of ageing...
April 2017: Pract Lab Med
https://www.readbyqxmd.com/read/28813505/allostatic-load-as-a-predictor-of-all-cause-and-cause-specific-mortality-in-the-general-population-evidence-from-the-scottish-health-survey
#10
Tony Robertson, Gayle Beveridge, Catherine Bromley
Allostatic load is a multiple biomarker measure of physiological 'wear and tear' that has shown some promise as marker of overall physiological health, but its power as a risk predictor for mortality and morbidity is less well known. This study has used data from the 2003 Scottish Health Survey (SHeS) (nationally representative sample of Scottish population) linked to mortality records to assess how well allostatic load predicts all-cause and cause-specific mortality. From the sample, data from 4,488 men and women were available with mortality status at 5 and 9...
2017: PloS One
https://www.readbyqxmd.com/read/28804509/lifetime-stress-exposure-and-health-a-review-of-contemporary-assessment-methods-and-biological-mechanisms
#11
Grant S Shields, George M Slavich
Life stress is a central construct in health research because it is associated with increased risk for a variety of serious mental and physical health problems, including anxiety disorders, depression, cardiovascular disease, autoimmune disorders, Alzheimer's disease, certain cancers, and other diseases of aging. In this review, we examine how lifetime stress exposure contributes to elevated disease risk, and explore ongoing measurement and scientific issues related to this topic. To accomplish these goals, we first review existing instruments that have been developed for assessing perceived stress, self-reported life events, interviewer-assessed life stressors, and lifetime stress exposure...
August 2017: Social and Personality Psychology Compass
https://www.readbyqxmd.com/read/28765100/pacing-conventional-physical-activity-and-active-video-games-to-increase-physical-activity-for-adults-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome-protocol-for-a-pilot-randomized-controlled-trial
#12
Katia Elizabeth Ferrar, Ashleigh E Smith, Kade Davison
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious illness of biological origin characterized by profound physical and cognitive exhaustion and postexertion malaise. Pacing is a common strategy used to manage available energy and complete activities of daily living; yet little research has investigated this as a strategy to increase physical activity levels. Typically, people living with ME/CFS are faced by unique barriers to physical activity participation and are less physically active than healthy peers...
August 1, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28752903/erythropoietin-prevents-the-effect-of-chronic-restraint-stress-on-the-number-of-hippocampal-ca3c-dendritic-terminals-relation-to-expression-of-genes-involved-in-synaptic-plasticity-angiogenesis-inflammation-and-oxidative-stress-in-male-rats
#13
Nadia Aalling, Ida Hageman, Kamilla Miskowiak, Dariusz Orlowski, Gregers Wegener, Gitta Wortwein
Stress-induced allostatic load affects a variety of biological processes including synaptic plasticity, angiogenesis, oxidative stress, and inflammation in the brain, especially in the hippocampus. Erythropoietin (EPO) is a pleiotropic cytokine that has shown promising neuroprotective effects. Recombinant human EPO is currently highlighted as a new candidate treatment for cognitive impairment in neuropsychiatric disorders. Because EPO enhances synaptic plasticity, attenuates oxidative stress, and inhibits generation of proinflammatory cytokines, EPO may be able to modulate the effects of stress-induced allostatic load at the molecular level...
July 28, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28709033/vegetated-land-cover-near-residence-is-associated-with-reduced-allostatic-load-and-improved-biomarkers-of-neuroendocrine-metabolic-and-immune-functions
#14
Andrey I Egorov, Shannon M Griffin, Reagan R Converse, Jennifer N Styles, Elizabeth A Sams, Anthony Wilson, Laura E Jackson, Timothy J Wade
BACKGROUND: Greater exposure to urban green spaces has been linked to reduced risks of depression, cardiovascular disease, diabetes and premature death. Alleviation of chronic stress is a hypothesized pathway to improved health. Previous studies linked chronic stress with a biomarker-based composite measure of physiological dysregulation known as allostatic load. OBJECTIVE: This study's objective was to assess the relationship between vegetated land cover near residences and allostatic load...
October 2017: Environmental Research
https://www.readbyqxmd.com/read/28693012/stress-measured-by-allostatic-load-in-neurologically-impaired-children-the-importance-of-nutritional-status
#15
Valeria Calcaterra, Hellas Cena, Annalisa de Silvestri, Riccardo Albertini, Mara De Amici, Mario Valenza, Gloria Pelizzo
BACKGROUND: Allostatic load (AL) is the cumulative physiological wear and tear that results from repeated efforts to adapt to stressors over time. The life stress response is modified by nutritional status. AIM: We estimated AL scores among neurologically impaired (NI) children; the association with malnutrition was also evaluated. METHODS: Forty-one patients with severe disabilities were included. Data based on 15 biomarkers were used to create the AL score...
July 10, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28659244/long-term-physical-health-consequences-of-perceived-inequality-results-from-a-twin-comparison-design
#16
Joseph A Schwartz
RATIONALE: Previous research has identified long-term exposure to stress as a risk factor for negative mental and physical health outcomes. This pattern of findings suggests that environmental stimuli that evoke feelings of stress or strain may also result in physiological responses, which may accumulate over the life course and ultimately increase the overall risk of various physical health conditions. This physiological "wear and tear" resulting from sustained levels of stress or strain has been previously operationalized as allostatic load (AL), a comprehensive indicator of stress exposure...
June 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28651371/sleep-and-physiological-dysregulation-a-closer-look-at-sleep-intraindividual-variability
#17
Bei Bei, Teresa E Seeman, Judith E Carroll, Joshua F Wiley
Study Objectives: Variable daily sleep (i.e., higher intraindividual variability; IIV) is associated with negative health consequences, but potential physiological mechanisms are poorly understood. This study examined the associations between sleep timing, duration, and quality IIV and physiological dysregulation, with diurnal cortisol trajectories as a proximal outcome, and allostatic load (AL) as a multi-system distal outcome. Methods: Participants are 436 adults (Mage±SD=54...
June 23, 2017: Sleep
https://www.readbyqxmd.com/read/28643579/religious-participation-and-biological-functioning-in-mexico
#18
Terrence D Hill, Sunshine M Rote, Christopher G Ellison
OBJECTIVE: Although several studies suggest that religious involvement tends to favor healthy biological functioning, most of this work has been conducted in the United States. This study explores the association between religious participation and biological functioning in Mexico. METHOD: The data are drawn from two waves of the Mexican Health and Aging Study (2003-2012) to assess continuous and categorical biomarker specifications. RESULTS: Across specifications, religious participation in 2003 is associated with lower levels of waist-to-hip ratio, total cholesterol, pulse rate, and overall allostatic load in 2012...
June 1, 2017: Journal of Aging and Health
https://www.readbyqxmd.com/read/28625102/spatiotemporal-meta-analysis-reviewing-health-psychology-phenomena-over-space-and-time
#19
Blair T Johnson, Ellen K Cromley, Natasza Marrouch
Individual studies of health psychology are samples taken in particular places at particular times. The results of such studies manifest multiple processes, including those associated with individual, sample, intervention, and study design characteristics. Although extant meta-analyses of health phenomena have routinely considered these factors to explain heterogeneity, they have tended to neglect the environments where studies are conducted, which is ironic, as health phenomena cluster in space and times (e...
September 2017: Health Psychology Review
https://www.readbyqxmd.com/read/28576664/uncertainty-and-stress-why-it-causes-diseases-and-how-it-is-mastered-by-the-brain
#20
REVIEW
Achim Peters, Bruce S McEwen, Karl Friston
The term 'stress' - coined in 1936 - has many definitions, but until now has lacked a theoretical foundation. Here we present an information-theoretic approach - based on the 'free energy principle' - defining the essence of stress; namely, uncertainty. We address three questions: What is uncertainty? What does it do to us? What are our resources to master it? Mathematically speaking, uncertainty is entropy or 'expected surprise'. The 'free energy principle' rests upon the fact that self-organizing biological agents resist a tendency to disorder and must therefore minimize the entropy of their sensory states...
September 2017: Progress in Neurobiology
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