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Allostatic load

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https://www.readbyqxmd.com/read/29108934/cardiovascular-control-is-associated-with-pair-bond-success-in-male-prairie-voles
#1
Robert Lewis, Brek Wilkins, Bruce Benjamin, J Thomas Curtis
Social support structures reduce mortality and morbidity in humans, but the mechanisms underlying these reductions are not fully understood. The prevailing hypothesis is that social support buffers stress and reduces allostatic load, thereby increasing longevity. However, the possibility that affiliative social interactions confer health benefits independent of stress buffering is understudied. We examined autonomic function in prairie voles - arguably the premier species for modeling human social affiliation - to assess the possibility that the formation of strong social bonds alters autonomic function and contributes to health benefits...
October 2, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29107462/each-meal-matters-in-the-exposome-biological-and-community-considerations-in-fast-food-socioeconomic-associations
#2
Susan L Prescott, Alan C Logan
Advances in omics and microbiome technology have transformed the ways in which the biological consequences of life in the 'ecological theatre' can be visualized. Exposome science examines the total accumulated environmental exposures (both detrimental and beneficial) as a means to understand the response of the 'total organism to the total environment' over time. The repetitive stimulation of compensatory physiological responses (immune, cardiovascular, neuroendocrine) in response to stress - including sources of stress highly relevant to socioeconomic disadvantage - may lead to metabolic dysregulation and cellular damage, ultimately influencing behavior and disease...
September 27, 2017: Economics and Human Biology
https://www.readbyqxmd.com/read/29082305/explaining-racial-and-ethnic-inequalities-in-postpartum-allostatic-load-results-from-a-multisite-study-of-low-to-middle-income-woment
#3
Patricia O'Campo, Christine Dunkel Schetter, Christine M Guardino, Maxine Reed Vance, Calvin J Hobel, Sharon Landesman Ramey, Madeleine U Shalowitz
BACKGROUND: Racial and ethnic inequalities in women's health are widely documented, but not for the postpartum period, and few studies examine whether neighborhood, psychosocial, and biological factors explain these gaps in women's health. METHODS: Using prospective longitudinal data collected from 1766 low to middle income women between 2008 and 2012 by the Community Child Health Network (CCHN), we tested the extent to which adjustment for neighborhood, economic, psychological, and medical conditions following a birth explained differences between African American, Latina, and White women in an indicator of physiological dysregulation allostatic load (AL), at one year postpartum as measured by 10 biomarkers: Body Mass Index, Waist Hip Ratio, systolic and diastolic blood pressure, high sensitivity C-reactive protein, Hemoglobin A1c, high-density lipoprotein and cholesterol ratio, and diurnal cortisol...
December 2016: SSM—Population Health
https://www.readbyqxmd.com/read/29078038/influence-of-supraphysiological-cortisol-manipulation-on-predator-avoidance-behaviours-and-physiological-responses-to-a-predation-threat-in-a-wild-marine-teleost-fish
#4
Michael J Lawrence, Erika J Eliason, Jacob W Brownscombe, Kathleen M Gilmour, John W Mandelman, Lee F G Gutowsky, Steven J Cooke
The stress axis in teleost fish attempts to maintain internal homeostasis in the face of allostatic loading. However, stress axis induction has been associated with a higher predation rate in fish. To date, the physiological and behavioural factors associated with this outcome are poorly understood. The purpose of the present study was to investigate the impact of experimental cortisol elevation on anti-predator behaviour and physiological responses to predator presence. We hypothesized that semi-chronic cortisol elevation would increase susceptibility to predation by increasing stress-induced risk taking behaviours...
October 27, 2017: Integrative Zoology
https://www.readbyqxmd.com/read/29062338/allostatic-load-and-heart-rate-variability-as-health-risk-indicators
#5
Margaretha Viljoen, Nicolaas Claassen
BACKGROUND: Uncertainty often exists about the comparability of results obtained by different health risk indicator systems. OBJECTIVES: To compare two health risk indicator systems, i.e, allostatic load and heart rate variability (HRV). Additionally, to investigate the feasibility of inclusion of HRV indicators into allostatic load assessments and which HRV indicators are best to introduce. METHODS: Allostatic loads were calculated based on blood pressure, waist-to-hip ratio, BMI, cholesterol, HDL-C, LDL-C, CRP, albumin, glycosylated haemoglobin, blood glucose and cortisol excretion...
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29024973/re-employment-job-quality-health-and-allostatic-load-biomarkers-prospective-evidence-from-the-uk-household-longitudinal-study
#6
Tarani Chandola, Nan Zhang
Background: There is little evidence on whether becoming re-employed in poor quality work is better for health and well-being than remaining unemployed. We examined associations of job transition with health and chronic stress-related biomarkers among a population-representative cohort of unemployed British adults. Methods: A prospective cohort of 1116 eligible participants aged 35 to 75 years, who were unemployed at wave 1 (2009/10) of the UK Household Longitudinal Study, were followed up at waves 2 (2010/11) and 3 (2011/12) for allostatic load biomarkers and self-reported health...
August 10, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29016550/assessing-lifetime-stress-exposure-using-the-stress-and-adversity-inventory-for-adults-adult-strain-an-overview-and-initial-validation
#7
George M Slavich, Grant S Shields
OBJECTIVE: Numerous theories have proposed that acute and chronic stressors may exert a cumulative effect on lifespan health by causing biological "wear and tear", or allostatic load, which in turn promotes disease. Very few studies have directly tested such models, though, partly because of the challenges associated with efficiently assessing stress exposure over the entire life course. To address this issue, we developed the first online system for systematically assessing lifetime stress exposure, called the Stress and Adversity Inventory (STRAIN), and describe its initial validation here...
October 10, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29016420/prevention-strategies-in-post-tbi-depression-in-older-adults-a-case-study
#8
Esther Bay, Anne Marie Garbinski, Susan E Maycock
PURPOSE: The purpose of this study was to describe a theoretically focused intervention aimed toward chronic stress and depressive symptom management that is coordinated by a case manager and delivered within a home environment by the caregiver. PRIMARY PRACTICE SETTING: Home care, community setting. METHODS: A case study of an older adult with traumatic brain injury (TBI) secondary to a fall who had significant allostatic load at the time of his injury...
November 2017: Professional Case Management
https://www.readbyqxmd.com/read/28982528/childhood-adolescent-stressors-and-allostatic-load-in-adulthood-support-for-a-calibration-model
#9
Mark T Berg, Ronald L Simons, Ashley Barr, Steven R H Beach, Robert A Philibert
RATIONALE: Past research has established an association between childhood and adolescent stressors and elevated inflammatory and metabolic biomarkers in adulthood, but questions remain about the theoretical model most suited to explain this association. OBJECTIVE: This study examined alternative hypotheses from four theoretical models regarding the link between exposure to stressful early life circumstances and cumulative biological risk, or allostatic load, in adulthood...
November 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28963986/a-systematic-review-of-allostatic-load-in-relation-to-socioeconomic-position-poor-fidelity-and-major-inconsistencies-in-biomarkers-employed
#10
REVIEW
Sarah C Johnson, Francesca L Cavallaro, David A Leon
BACKGROUND: The association between disease and socioeconomic position (SEP) is well established. Allostatic load (AL), or physiological 'wear and tear', is a concept that aims to elucidate the biological consequences of stress that may underlie these associations. The primary objective of this paper is to review the biomarkers and methods used to operationalise the concept of AL in studies analysing the association between AL and SEP. METHODS: Four databases (Embase, Global Health, MEDLINE, and PsychINFO) were searched using terms related to AL, biomarkers and SEP...
September 19, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28936179/seasonal-variations-in-heart-rate-variability-as-an-indicator-of-stress-in-free-ranging-pregnant-przewalski-s-horses-e-ferus-przewalskii-within-the-hortob%C3%A3-gy-national-park-in-hungary
#11
Friederike Pohlin, Kristin Brabender, Gerhard Fluch, Gabrielle Stalder, Thierry Petit, Chris Walzer
Background: Ecosystems with seasonal fluctuations in climate and food availability present physiological challenges to resident mammals and may cause "stress." The two predominant physiological responses to stressors are (1) the activation of the hypothalamic-pituitary-adrenal axis and (2) the modulation of the autonomic nervous system. To date, the primary indicator for "stress" in wildlife- and zoo animal research are glucocorticoid levels. By measuring the autonomic regulation of cardiac activity, particularly the vagal tone, heart rate variability (HRV) is presently emerging as a suitable indicator of "stress" in farm- and domestic animal research...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28926525/effect-of-a-mentor-based-supportive-expressive-program-be-resilient-to-breast-cancer-on-survival-in-metastatic-breast-cancer-a-randomised-controlled-intervention-trial
#12
RANDOMIZED CONTROLLED TRIAL
Zeng Jie Ye, Hong Zhong Qiu, Mu Zi Liang, Mei Ling Liu, Peng Fei Li, Peng Chen, Zhe Sun, Yuan Liang Yu, Shu Ni Wang, Zhang Zhang, Kun Lun Liao, Cai Fen Peng, Hui Huang, Guang Yun Hu, Yun Fei Zhu, Zhen Zeng, Qu Hu, Jing Jing Zhao
BACKGROUND: Because of medical advances, metastatic breast cancer (MBC) is now viewed as a chronic disease, rather than an imminent death sentence. Helping women live with this disease requires more than a medical approach to symptoms. Thus, a mentor-based and supportive-expressive program 'Be Resilient to Breast Cancer' (BRBC) was designed to help Chinese women with MBC enhance their resilience levels, biopsychosocial functions, and potentially extend their life span. METHODS: A total of 226 women with MBC were randomly assigned, in a 1 : 1 ratio, to an intervention group (IG) that participated in BRBC or to a control group (CG) that received no intervention...
November 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28918418/new-aspects-in-the-pathomechanism-of-diseases-of-civilization-particularly-psychosomatic-disorders-part-1-theoretical-background-of-a-hypothesis
#13
Andras Sikter, Zoltan Rihmer, Roberto de Guevara
The stress defence-cascade is mostly not biphasic as Cannon thought, the sympathicotonic stress response is preceded by a vagotonic phase called freeze response. Alteration of the carbon dioxide level plays an important role during defence-cascade as its changes interfere with stress hormones, e.g. with catecholamines, thus affecting the degree of arousal. In case of humans, learned behaviour dominates instead of instinctive, so the fight-or-flight often lags; the consequence can be persistent hypocapnia or hypercapnia...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28918243/homeostatic-systems-biocybernetics-and-autonomic-neuroscience
#14
REVIEW
David S Goldstein, Irwin J Kopin
In this review we describe a series of major concepts introduced during the past 150years that have contributed to our current understanding about how physiological processes required for well-being and survival are regulated. One can theorize that hierarchical networks involving input-output relationships continuously orchestrate and learn adaptive patterns of observable behaviors, cognition, memory, mood, and autonomic systems. Taken together, these networks function as "good regulators" determining levels of internal variables and act as if there were homeostatic comparators ("homeostats")...
September 5, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28880949/maternal-hypothalamic-pituitary-adrenal-axis-response-to-foraging-uncertainty-a-model-of-individual-vs-social-allostasis-and-the-superorganism-hypothesis
#15
Jeremy D Coplan, Nishant K Gupta, Asif Karim, Anna Rozenboym, Eric L P Smith, John G Kral, Leonard A Rosenblum
INTRODUCTION: Food insecurity is a major global contributor to developmental origins of adult disease. The allostatic load of maternal food uncertainty from variable foraging demand (VFD) activates corticotropin-releasing factor (CRF) without eliciting hypothalamic-pituitary-adrenal (HPA) activation measured on a group level. Individual homeostatic adaptations of the HPA axis may subserve second-order homeostasis, a process we provisionally term "social allostasis." We postulate that maternal food insecurity induces a "superorganism" state through coordination of individual HPA axis response...
2017: PloS One
https://www.readbyqxmd.com/read/28880686/preliminary-evidence-of-attenuated-blood-pressure-reactivity-to-acute-stress-in-adults-following-a-recent-marital-separation
#16
Austin M Grinberg, Karey L O'Hara, Dave A Sbarra
OBJECTIVE: This study explores cardiovascular reactivity during an acute-stress task in a sample of recently separated adults. DESIGN: In a cross-sectional design, we examined the association between adults' subjective separation-related distress and changes in heart rate and blood pressure across the acute-stress laboratory paradigm in a sample of 133 (n = 49 men) recently separated adults. MAIN OUTCOME MEASURES: Heart rate (HR) and Blood pressure (BP) were recorded across a resting baseline period, a math stressor task, and a recovery period...
September 7, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28870356/the-childhood-roots-of-cardiovascular-disease-disparities
#17
REVIEW
Donald A Barr
A recent national review of the social determinants of cardiovascular disease (CVD) underscored the growing recognition that poor socioeconomic conditions early in life place children at higher risk for CVD as adults. There is growing evidence that chronic elevation of allostatic load as a consequence of high levels of early childhood stress can trigger early atherosclerotic changes in children independently of behaviors. Elevated levels of circulating cortisol have been documented in children as young as 4 years who were raised in highly stressful circumstances...
September 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28862266/genomic-and-epigenomic-mechanisms-of-glucocorticoids-in-the-brain
#18
REVIEW
Jason D Gray, Joshua F Kogan, Jordan Marrocco, Bruce S McEwen
Following the discovery of glucocorticoid receptors in the hippocampus and other brain regions, research has focused on understanding the effects of glucocorticoids in the brain and their role in regulating emotion and cognition. Glucocorticoids are essential for adaptation to stressors (allostasis) and in maladaptation resulting from allostatic load and overload. Allostatic overload, which can occur during chronic stress, can reshape the hypothalamic-pituitary-adrenal axis through epigenetic modification of genes in the hippocampus, hypothalamus and other stress-responsive brain regions...
November 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28856337/neurobiological-and-systemic-effects-of-chronic-stress
#19
Bruce S McEwen
The brain is the central organ of stress and adaptation to stress because it perceives and determines what is threatening, as well as the behavioral and physiological responses to the stressor, which promote adaptation ("allostasis") but also contribute to pathophysiology ("allostatic load/overload") when overused and dysregulated. The adult as well as developing brain possesses a remarkable ability to show structural and functional plasticity in response to stressful and other experiences, including neuronal replacement, dendritic remodeling and synapse turnover...
January 2017: Chronic stress
https://www.readbyqxmd.com/read/28856219/circulating-markers-of-ageing-and-allostatic-load-a-slow-train-coming
#20
Paul G Shiels, Peter Stenvinkel, Jeroen P Kooman, Dagmara McGuinness
Dealing with the growing burden of age-related morbidities is one of the greatest challenges facing modern society. How we age across the lifecourse and how psychosocial and lifestyle factors interplay with the biology of ageing remains to be fully elucidated. Sensitive and specific biomarkers with which to interrogate the biology of the ageing process are sparse. Recent evidence suggests that non-coding RNAs are key determinants of such processes and that these can be used as potential circulatory bio-markers of ageing...
April 2017: Pract Lab Med
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