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Filippo Molinari, Daniele Rimini, William Liboni, U Rajendra Acharya, Marianno Franzini, Sergio Pandolfi, Giovanni Ricevuti, Francesco Vaiano, Luigi Valdenassi, Vincenzo Simonetti
Ozone major autohemotherapy is effective in reducing the symptoms of multiple sclerosis (MS) patients, but its effects on brain are still not clear. In this work, we have monitored the changes in the cerebrovascular pattern of MS patients and normal subjects during major ozone autohemotherapy by using near-infrared spectroscopy (NIRS) as functional and vascular technique. NIRS signals are analyzed using a combination of time, time-frequency analysis and nonlinear analysis of intrinsic mode function signals obtained from empirical mode decomposition technique...
October 12, 2016: Medical & Biological Engineering & Computing
N S Abyshov, A G Abdullaev, E D Zakirdzhaev, R A Guliev, M B Akhmedov, G T Tagizade, G M Zeinalova, L D Mamedova
AIM: to evaluate the results of combined treatment of thromboangiitis obliterans with severe lower limb ischemia using prolonged epidural anaesthesia and autohemotherapy with ozone. MATERIAL AND METHODS: It was analyzed treatment of 125 patients with thromboangiitis obliterans and severe lower limb ischemia. Patients were divided into 2 groups. Control group consisted of 60 patients who underwent conventional perioperative therapy with anticoagulants, antiplatelet agents, dextrans, metabolic drugs, glucocorticoids, angioprotectors, narcotic and non-narcotic analgesics...
2016: Khirurgiia
Xiao-Na Wu, Tao Zhang, Jun Wang, Xiao-Yan Liu, Zhen-Sheng Li, Wei Xiang, Wei-Qing Du, Hong-Jun Yang, Tie-Gen Xiong, Wen-Ting Deng, Kai-Run Peng, Su-Yue Pan
Major ozonated autohemotherapy has been shown to promote recovery of upper limb motor function in patients with acute cerebral infarction, but whether major ozonated autohemotherapy affects remote injury remains poorly understood. Here, we assumed that major ozonated autohemotherapy contributes to recovery of clinical function, possibly by reducing remote injury after acute cerebral infarction. Sixty acute cerebral infarction patients aged 30-80 years were equally and randomly allocated to ozone treatment and control groups...
July 2016: Neural Regeneration Research
A Barone, M Otero-Losada, A M Grangeat, G Cao, F Azzato, A Rodríguez, J Milei
BACKGROUND: In-stent restenosis and poor re-endothelization usually follow percutaneous transluminal coronary angioplasty, even using drug-eluting stents, due to inflammation and oxidative stress. Medical ozone has antioxidant and anti-inflammatory properties and has not been evaluated in this context. OBJECTIVES: To evaluate whether ozonotherapy might reduce restenosis following bare metal stents implantation in relation to the redoxin system in pigs. METHODS: Twelve male Landrace pigs (51±9kg) underwent percutaneous transluminal circumflex coronary arteries bare metal stent implantation under heparine infusion and fluoroscopical guidance, using standard techniques...
November 15, 2016: International Journal of Cardiology
Eyup Burak Sancak, Hakan Turkön, Selma Çukur, Sevilay Erimsah, Alpaslan Akbas, Murat Tolga Gulpinar, Huseyin Toman, Hasan Sahin, Metehan Uzun
Medical ozone has therapeutic properties as an antimicrobial, anti-inflammatory, modulator of antioxidant defense system. Major ozonated autohemotherapy (MOA) is a new therapeutic approach that is widely used in the treatment of many diseases. The objective of the present study was to determine whether preischemic application of MOA would attenuate renal ischemia-reperfusion injury (IRI) in rabbits. Twenty-four male New Zealand white rabbits were divided into four groups, each including six animals: (1) Sham-operated group, (2) Ozone group (the MOA group without IRI), (3) IR group (60 min ischemia followed by 24 h reperfusion), and (4) IR + MOA group (MOA group)...
February 2016: Inflammation
Nao Tsuzuki, Yoshiro Endo, Lisa Kikkawa, Kenji Korosue, Yasuyuki Kaneko, Akira Kitauchi, Hiromu Katamoto, Yuichi Hidaka, Mitsuyoshi Hagio, Shidow Torisu
The performance of horses undergoing regular intense exercise is adversely affected by oxidative stress. Thus, it is important to increase antioxidant production in horses in order to reduce oxidative stress. Ozonated autohemotherapy (OAHT) reportedly promotes antioxidant production. This study aimed to evaluate the effects of OAHT on antioxidant capacity. Ten Thoroughbred horses were used in this study. After the OAHT, we collected serum samples and measured biological antioxidant potential (BAP). We found that BAP began to increase after the OAHT and was significantly higher in the OAHT group than at 3 (P<0...
January 2016: Journal of Veterinary Medical Science
Çağın Mustafa Üreyen, Cem Yunus Baş, Şakir Arslan
We discuss the case of a 46-year-old male patient presenting to the emergency department with acute inferior myocardial infarction. Coronary angiography demonstrated a vasospasm of the left main coronary artery and proximal segment of the left anterior descending artery. Furthermore, a thrombotic total occlusion was ascertained in the right coronary artery. The vasospasm in the left main and left anterior descending artery disappeared after nitrate administration. We successfully implanted a stent to the thrombotic occlusion in the right coronary artery after predilatation...
June 27, 2015: Cardiology
Velio Bocci, Iacopo Zanardia, Giuseppe Valacchi, Emma Borrelli, Valter Travagli
The state-of-the-art of oxygen-ozone therapy is now clarified and all the mechanisms of action of medical ozone are within classical biochemistry and molecular biology. The outcomes of standard treatments in peripheral arterial occlusive disease (PAOD) and dry-form of age-related macular degeneration (AMD) have been compared with the documented therapeutic results achieved with ozonated autohemotherapy (O-AHT). On the other hand, the clinical data of O-AHT on stroke remain indicative. As the cost of O-AHT is almost irrelevant, its application in all public hospitals, especially those of poor Countries, would allow two advantages: the first is for the patient, who will improve her/his conditions, and the second is for Health Authorities burdened with increasing costs...
2015: Cardiovascular & Hematological Disorders Drug Targets
Iu S Vinnik, A B Salmina, O V Tepliakova, A I Drobushevskaia, E A Pozhilenkova, A V Morgun, M V Shapran, A O Kovalenko
Levels of interleukins-6, 8, 10, TNF-alpha and basic fibroblast growth factor (bFGF) were examined in peripheral blood of 60 patients with diabetes mellitus type II and soft tissues infections. It was revealed the elevated levels of proinflammatory (IL-6, 8), anti-inflammatory (IL-10) cytokines and basic fibroblast growth factor at the time of admission. Application of combined ozone therapy including ozonated autohemotherapy and superficial management of wounds with ozone-oxygen mixture resulted in significant decrease of IL-6, 8, 10 production and high level of bFGF on blood serum...
2015: Khirurgiia
Wan-Rong Zhang, Na Lang
OBJECTIVE: To explore the clinical efficacy and effect mechanism on chronic urticaria treated with moving cupping therapy combined with autohemotherapy with acupaint injection for desensitization at acupoints. METHODS: One hundred and four patients of chronic urticaria were randomized into a comprehensive therapy group and a medication group, 52 cases in each one. In the comprehensive therapy group, the moving cupping therapy along the governor vessel and bladder meridian of foot-taiyang was applied combined with autohemotherapy with acupaint injection for desensitization at acupoints...
December 2014: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Iu S Vinnik, A B Salmina, O V Tepliakova, A I Drobushevskaia, N A Malinovskaia, E A Pozhilenkova, A V Morgun, A G Gitlina
Clinical results of wound healing dynamics were studied in 60 patients with soft-tissue infection against the background of diabetes mellitus type II. At the same time the study considered indices of intercellular contacts protein tissue expression such as connexin 43 (Cx43) and basic fibroblast growth factor receptors (bFGFR). The basic therapy of biopsy material of wound borders was applied. The reduction of bFGFR expression and the minor growth of Cx43 expression were observed. The pain syndrome proceeded for a long time and there were signs of perifocal inflammation, retard wound healing with granulation tissue...
2014: Vestnik Khirurgii Imeni I. I. Grekova
Lian-Yun Li, Jia-Xiang Ni
Gout is a common form of arthritis; however, there are currently no effective therapies available. Ozonated autohemotherapy (O3-AHT) is a controversial, but successful method of treatment for a number of diseases. The present study is the first pilot study investigating the application of O3-AHT in patients with hyperuricemia and gout. In total, 10 patients diagnosed with gout were recruited and subjected to O3-AHT. Self-reported pain visual analog scale (VAS) scores and creatinine clearance values were evaluated prior to (T0), during (after the fifth session of O3-AHT treatment; 1-4 weeks; T1) and following the treatment course (5-28 weeks; T2)...
November 2014: Experimental and Therapeutic Medicine
F Molinari, V Simonetti, M Franzini, S Pandolfi, F Vaiano, L Valdenassi, W Liboni
Ozone autohemotherapy is an emerging therapeutic technique that is gaining increasing importance in treating neurological disorders. A validated and standard methodology to assess the effect of such therapy on brain metabolism and circulation is however still lacking. We used a near-infrared spectroscopy (NIRS) system to monitor the cerebral metabolism and a transcranial Doppler (TCD) to monitor the blood flow velocity in the middle cerebral arteries. Fifty-four subjects (32 neurological patients and 22 controls) were tested before, during, and after ozone autohemotherapy...
July 2014: International Journal of Immunopathology and Pharmacology
N S Abyshov, É D Zakirdzhaev, R A Guliev
No abstract text is available yet for this article.
2014: Khirurgiia
Xiaona Wu, Zhensheng Li, Xiaoyan Liu, Haiyan Peng, Yongjun Huang, Gaoquan Luo, Kairun Peng
Major ozonated autohemotherapy is classically used in treating ischemic disorder of the lower limbs. In the present study, we performed major ozonated autohemotherapy treatment in patients with acute cerebral infarction, and assessed outcomes according to the U.S. National Institutes of Health Stroke Score, Modified Rankin Scale, and transcranial magnetic stimulation motor-evoked potential. Compared with the control group, the clinical total effective rate and the cortical potential rise rate of the upper limbs were significantly higher, the central motor conduction time of upper limb was significantly shorter, and the upper limb motor-evoked potential amplitude was significantly increased, in the ozone group...
February 15, 2013: Neural Regeneration Research
Abdolkarim Sheikhi, Mohsen Azarbeig, Hamid Karimi
No abstract text is available yet for this article.
August 2014: Annals of Dermatology
Lei Yu, Xiaojie Lu, Huachao Shi, Qing Wang
No abstract text is available yet for this article.
August 2014: American Journal of Emergency Medicine
G Lintas, F Molinari, V Simonetti, M Franzini, W Liboni
Ozone autohemotherapy is an emerging therapeutic technique that is gaining increasing importance in treating neurological disorders. A validated and standard methodology to assess the effect of such therapy on brain metabolism and circulation is however still lacking. We used a near-infrared spectroscopy system (NIRS) to monitor the cerebral oxygenation of 9 subjects: 4 remitting-relapsing multiple sclerosis (MS) sufferers and 5 controls. Subjects were tested before, during, and after ozone autohemotherapy...
2013: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Ella Leung, Gennady Landa
Age-related macular degeneration (ARMD) is the leading cause of irreversible blindness in developed countries. There are currently no cures, but there are promising potential therapies that target the underlying disease mechanisms of dry ARMD. Stem cells, ciliary neurotrophic factor, rheopheresis, ozonated autohemotherapy and prostaglandins show promise in stabilizing or improving visual acuity. Age-Related Eye Disease Study vitamins may reduce progression to severe ARMD. Adjuvant therapy like low vision rehabilitation and implantable miniature telescopes may help patients adjust to the sequelae of their disease, and herbal supplementation with saffron, zinc monocysteine and phototrop may be helpful...
September 2013: Expert Review of Clinical Pharmacology
Chao Liang, Tao Jiang
OBJECTIVE: To explore the clinical efficacy and the mechanism of acupoint autohemotherapy in the treatment of allergic rhinitis. METHODS: Forty-five cases were randomized into an autohemotherapy group (24 cases) and a western medication group (21 cases). In the autohemotherapy group, the acupoint autohemotherapy was applied to the bilateral Dingchuan (EX-B 1), Fengmen (BL 12), Feishu (BL 13), Quchi (LI 11), Zusanli (ST 36) and the others. In the western medication group, loratadine tablets were prescribed...
December 2012: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
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