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secondary hyperparathiroidism

Al Negri
Phosphatonins are regulatory factors of phosphate metabolism and the FGF23 is the best studied of them. This has produced a change in our understanding in mineral metabolism and specifically of phosphate regulation. FGF23 is a 251-amino acid factor that differs from other FGF family members by having a 71-amino acid extension on the carboxyl-terminal end of the molecule that is specific for this factor. It is primarily produced by osteocytes in bone. It has a central role in phosphate homeostasis regulation, producing phosphaturia, and in vitamin D metabolism, inhibiting its production by suppression of renal 1 Alfa hydroxylase...
2009: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
J Portolés, A Tato, P López-Sánchez, E Gruss, F Cava, A Ortigosa, M D Molano
BACKGROUND: Cinacalcet has improved the management of hyperparathiroidism (HPTH) in hemodialysis. To our knowledge there are no specific studies on peritoneal dialysis (PD). AIM: The aim of the present study was to evaluate the efficacy of Cinacalcet on the achievement of optimal and suboptimal targets on treatment of hyperparathiroidism (HPTH) in PD patients. As secondary objectives we have studied the safety of treatment and estimate the mean time to reach these targets, and evaluate economic cost...
2008: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
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