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https://www.readbyqxmd.com/read/28644562/efficacy-of-ipragliflozin-as-monotherapy-or-as-add-on-therapy-with-other-oral-antidiabetic-medications-in-treating-type-2-diabetes-in-japanese-patients-with-inadequate-glycemic-control-a-subgroup-analysis-based-on-patient-characteristics
#1
Takeshi Osonoi, Shinya Nakamoto, Miyoko Saito, Atsuko Tamasawa, Hidenori Ishida, Yusuke Osonoi
AIMS/INTRODUCTION: The aim of the present study was to evaluate the efficacy and safety of ipragliflozin in treating Japanese type 2 diabetic patients with inadequate glycemic control by investigating diurnal variations of blood glucose and body composition. MATERIALS AND METHODS: This was an investigator-initiated, multicenter, prospective study with a 6-month treatment period. The primary outcome investigated was change in hemoglobin A1c levels from baseline. Secondary outcomes included changes in fasting plasma glucose, insulin resistance, variations in 24-h glucose levels detected by continuous glucose monitoring, body weight, body composition, waist circumference, and serum lipids...
June 23, 2017: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/28643579/religious-participation-and-biological-functioning-in-mexico
#2
Terrence D Hill, Sunshine M Rote, Christopher G Ellison
OBJECTIVE: Although several studies suggest that religious involvement tends to favor healthy biological functioning, most of this work has been conducted in the United States. This study explores the association between religious participation and biological functioning in Mexico. METHOD: The data are drawn from two waves of the Mexican Health and Aging Study (2003-2012) to assess continuous and categorical biomarker specifications. RESULTS: Across specifications, religious participation in 2003 is associated with lower levels of waist-to-hip ratio, total cholesterol, pulse rate, and overall allostatic load in 2012...
June 1, 2017: Journal of Aging and Health
https://www.readbyqxmd.com/read/28641570/1h-post-load-blood-glucose-in-the-identification-of-proatherogenic-cardiometabolic-profile-in-obesity
#3
Djordje S Popovic, Dragana Tomic-Naglic, Milena Mitrovic, Zeljko Zivanovic, Bojan Vukovic, Edita Stokic
BACKGROUND AND AIM: Current data show that 1h oral glucose tolerance test (OGTT) blood glucose (1h-BG) might identify persons at increased risk of developing type 2 diabetes and cardiovascular diseases more precisely than fasting blood glucose (FBG) and 2h OGTT blood glucose (2h-BG). The aim of study was to determine whether is justified to use 1h-BG, instead of traditional blood glucose measurements, in cardiometabolic profiling of obese individuals. METHOD: Cross-sectional study enrolled 60 obese individuals without previous history of diabetes and other cardiometabolic disorders...
June 13, 2017: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28639946/assessment-of-left-ventricular-systolic-function-in-patients-with-iron-deficiency-anemia-by-three-dimensional-speckle-tracking-echocardiography
#4
Qiao Zhou, Jiaqi Shen, Yue Liu, Runlan Luo, Bijun Tan, Guangsen Li
OBJECTIVE: The present study aimed to evaluate left ventricular (LV) systolic function in patients with iron deficiency anemia (IDA) by 3 dimensional speckle-tracking echocardiography (3DSTE). METHODS: Participants were grouped by hemoglobin (Hb) levels in order to study the effect of anemia on cardiac function. Group A included 40 healthy volunteers. Eighty-three patients who were diagnosed with IDA were divided into 2 groups according to the Hb level. Group B (Hb 9 g/dL) included 44 patients, while group C (Hb 6-9 g/dL) included 39 patients...
June 22, 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28637777/the-american-heart-association-ideal-cardiovascular-health-and-incident-type-2-diabetes-mellitus-among-blacks-the-jackson-heart-study
#5
Valery S Effoe, Mercedes R Carnethon, Justin B Echouffo-Tcheugui, Haiying Chen, Joshua J Joseph, Arnita F Norwood, Alain G Bertoni
BACKGROUND: The concept of ideal cardiovascular health (CVH), defined by the American Heart Association primarily for coronary heart disease and stroke prevention, may apply to diabetes mellitus prevention among blacks. METHODS AND RESULTS: Our sample included 2668 adults in the Jackson Heart Study with complete baseline data on 6 of 7 American Heart Association CVH metrics (body mass index, healthy diet, smoking, total cholesterol, blood pressure, and physical activity)...
June 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28637686/high-serum-phospholipid-dihomo-%C3%AE-linoleic-acid-concentration-and-low-%C3%AE-5-desaturase-activity-are-associated-with-increased-risk-of-type-2-diabetes-among-japanese-adults-in-the-hitachi-health-study
#6
Shamima Akter, Kayo Kurotani, Masao Sato, Takuya Hayashi, Keisuke Kuwahara, Yumi Matsushita, Tohru Nakagawa, Maki Konishi, Toru Honda, Shuichiro Yamamoto, Takeshi Hayashi, Mitsuhiko Noda, Tetsuya Mizoue
Background: The association between the circulating fatty acid (FA) composition and type 2 diabetes (T2D) has been reported in Western populations, but evidence is scarce among Asian populations, including Japanese, who consume large amounts of fish.Objective: The objective of the present study was to prospectively examine the association between circulating concentrations of individual FAs and T2D incidence among Japanese adults.Methods: We conducted a nested case-control study in a cohort of 4754 employees, aged 34-69 y, who attended a comprehensive health checkup in 2008-2009 and donated blood samples for the Hitachi Health Study...
June 21, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28628147/-association-between-social-support-and-self-management-behaviors-among-patients-with-diabetes-in-community
#7
(no author information available yet)
OBJECTIVE: To study the status quo of directive and nondirective support from family or friends among patients with diabetes in community and to explore the association between directive, nondirective support from family or friends and self-management behaviors. METHODS: The data of the subjects were from the "Community Diagnosis in Tongzhou District, Beijing" survey. Questionnaire-based investigation, physical examination and glycated hemoglobin test were conducted on 474 eligible patients in community...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28626098/-association-between-glycosylated-hemoglobin-and-%C3%A2-non-alcoholic-fatty-liver-disease-in-%C3%A2-health-examination-population
#8
Qian Zhang, Yang Yu, Mengfeng Yang, Xiuping Lin, Yulan Liu, Xianggui Xu
To investigate associations between glycosylated hemoglobin (HbA1c) levels and non-alcoholic fatty liver disease (NAFLD) in population who underwent periodic heath examination.
 Methods: A total of 912 subjects were selected from the health examination adults in University of Hong Kong Shenzhen Hospital from June to November 2013, and they were assigned into a NAFLD group, an else hepatic disease group, and a control group. The physical examination results of these subjects were analyzed retrospectively. 
 Results: The prevalence of NAFLD was 29...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28625506/long-term-cost-effectiveness-of-two-glp-1-receptor-agonists-for-the-treatment-of-type-2-diabetes-mellitus-in-the-italian-setting-liraglutide-versus-lixisenatide
#9
Barnaby Hunt, Nana Kragh, Ceilidh C McConnachie, William J Valentine, Maria C Rossi, Roberta Montagnoli
PURPOSE: Maintaining glycemic control is the key treatment target for patients with type 2 diabetes mellitus. In addition, the glucagon-like peptide-1 (GLP-1) receptor agonists may be associated with other favorable treatment characteristics, such as reduction in body weight and reduced risk of hypoglycemia compared with traditional diabetes interventions. The aim of the present analysis was to compare the long-term cost-effectiveness of 2 GLP-1 receptor agonists, liraglutide 1.8 mg and lixisenatide 20 μg (both administered once daily), in the treatment of patients with type 2 diabetes failing to achieve glycemic control with metformin monotherapy in the Italian setting...
June 15, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28625128/the-wnt-%C3%AE-catenin-signalling-pathway-inhibitor-sclerostin-is-a-biomarker-for-early-atherosclerosis-in-obesity
#10
Djordje S Popovic, Milena Mitrovic, Dragana Tomic-Naglic, Tijana Icin, Ivana Bajkin, Bojan Vukovic, Damir Benc, Zeljko Zivanovic, Branka Kovacev-Zavisic, Edita Stokic
BACKGROUND: Sclerostin is an inhibitor of the wingless-type mouse mammary tumor virus integration site family/β-catenin signalling pathway (WβcSP), which plays an important role in bone metabolism and in vascular biology. It could act protective regarding atherosclerosis development through its effect on WβcSP in vascular cells. Nevertheless, results of studies analyzing association between circulating sclerostin level (CSL) and atherosclerotic diseases (AD) are showing conflicting results...
June 18, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/28623932/impact-of-glycemic-control-on-aortic-stiffness-left-ventricular-mass-and-diastolic-longitudinal-function-in-type-2-diabetes-mellitus
#11
Michaela Kozakova, Carmela Morizzo, Alan G Fraser, Carlo Palombo
BACKGROUND: Poor glycemic control is associated with impaired left ventricular (LV) diastolic function in patients with type 2 diabetes mellitus (T2DM). Inappropriate LV mass increase and accelerated aortic stiffening were suggested to participate on deterioration of diastolic function. The present study investigated the inter-relationships between glycemic control, early diastolic and systolic longitudinal velocity of mitral annulus, LV mass and aortic stiffness in T2DM patients free of cardiovascular disease and with preserved LV ejection fraction, and compared them with those observed in healthy volunteers of similar age and sex distribution...
June 17, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28623551/which-patients-will-benefit-from-a-switch-in-therapy-from-premixed-insulin-to-insulin-glargine-plus-oral-antidiabetic-drugs-further-analysis-of-the-lantus-registry-study
#12
Shi Bu, Xuelian Zhang, Haiqing Zhu, Ying Shuai, Xiaoyan Xing, Wenying Yang
INTRODUCTION: This subgroup analysis of data from the 16-week Lantus Registry Study in China investigated the characteristics of patients with type 2 diabetes mellitus (T2DM) associated with clinical benefits of transitioning therapy from premixed insulin to insulin glargine (100 U/ml) plus oral antidiabetic drugs (OADs). METHODS: The modified intention-to-treat population of the Lantus Registry Study, comprising 1847 patients with T2DM, were included in the current subgroup analyses...
June 16, 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/28621680/associations-between-serum-bilirubin-levels-and-essential-trace-elements-status-in-an-adult-population
#13
You-Fan Peng, Ye-Sheng Wei
OBJECTIVE: This paper aims to evaluate the relations between serum bilirubin and essential trace elements in an adult population. RESULTS: Demographic and clinical data were stratified according to the median of serum bilirubin concentrations (50th percentiles). There were statistical differences in regarding with age, body mass index, white blood count, hemoglobin, mean corpuscular hemoglobin, alanine aminotransferase, creatinine, high-sensitivity C-reactive protein, iron, zinc and copper...
June 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28621283/assessment-of-levels-of-glycosylated-hemoglobin-in-patients-with-periodontal-pathologies-a-comparative-study
#14
Saurabh Wahi, Alok Tripathi, Shradha Wahi, Vikas D Mishra, Abhishek P Singh, Nikhil Sinha
INTRODUCTION: One of the potential sources for the occurrence of various systemic pathologies, such as cardiovascular diseases, cerebrovascular diseases, and respiratory diseases is periodontitis. Testing of glycosylated hemoglobin (HbA) is a highly standardized procedure and is becoming increasingly popular these days due to its cost-effectiveness and ease of use. Literature quotes numerous studies associating the peri-odontal diseases with various hemoglobin markers in diabetic and nondiabetic patients...
June 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28620311/physiological-adaptations-to-hypoxic-vs-normoxic-training-during-intermittent-living-high
#15
Stefan De Smet, Paul van Herpt, Gommaar D'Hulst, Ruud Van Thienen, Marc Van Leemputte, Peter Hespel
In the setting of "living high," it is unclear whether high-intensity interval training (HIIT) should be performed "low" or "high" to stimulate muscular and performance adaptations. Therefore, 10 physically active males participated in a 5-week "live high-train low or high" program (TR), whilst eight subjects were not engaged in any altitude or training intervention (CON). Five days per week (~15.5 h per day), TR was exposed to normobaric hypoxia simulating progressively increasing altitude of ~2,000-3,250 m...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28615262/predictors-of-anemia-in-women-of-reproductive-age-biomarkers-reflecting-inflammation-and-nutritional-determinants-of-anemia-brinda-project
#16
REVIEW
James P Wirth, Bradley A Woodruff, Reina Engle-Stone, Sorrel Ml Namaste, Victor J Temple, Nicolai Petry, Barbara Macdonald, Parminder S Suchdev, Fabian Rohner, Grant J Aaron
Background: Anemia in women of reproductive age (WRA) (age range: 15-49 y) remains a public health problem globally, and reducing anemia in women by 50% by 2025 is a goal of the World Health Assembly.Objective: We assessed the associations between anemia and multiple proximal risk factors (e.g., iron and vitamin A deficiencies, inflammation, malaria, and body mass index) and distal risk factors (e.g., education status, household sanitation and hygiene, and urban or rural residence) in nonpregnant WRA.Design: Cross-sectional, nationally representative data from 10 surveys (n = 27,018) from the Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project were analyzed individually and pooled by the infection burden and risk in the country...
June 14, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28615013/short-term-poor-glycemic-control-and-retinal-microvascular-changes-in-pediatric-type-1-diabetes-patients-in-singapore-a-pilot-study
#17
Ling-Jun Li, Ecosse Lamoureux, Tien Yin Wong, Ngee Lek
BACKGROUND: Poor glycemic control in Type 1 Diabetes (T1D) patients is strongly associated with an increased risk of diabetes-related microvascular complications later in life, but it is unclear whether short period of poor glycemic control in children with T1D can cause evident microvascular morphological changes long before any pathological manifestation. Our study aimed to investigate the longitudinal association between poor glycemic control and subsequent changes in retinal microvasculature, in a pilot study of 55 pediatric T1D patients from Singapore after a one-year follow-up...
June 15, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28613960/the-effect-of-air-pollution-on-diurnal-variation-of-performance-in-anaerobic-tests-cardiovascular-and-hematological-parameters-and-blood-gases-on-soccer-players-following-the-yo-yo-intermittent-recovery-test-level-1
#18
Nesrin Boussetta, Salma Abedelmalek, Khouloud Aloui, Nizar Souissi
This study aimed to investigate the effect of air pollution on diurnal variation of performance in anaerobic tests, cardiovascular and hematological parameters, and blood gases on soccer players following the Yo-Yo Intermittent Recovery Test Level-1 (YYIRT1). In a randomized order, 11 healthy soccer players (mean age: 21.8 [range: 20-24] years; height: 178.00 [range: 1.64-1.83] cm; body mass index [BMI]: 23.57 [range: 20.45-28.03] kg.m(-2)) performed a YYIRT1 at two different times of day (TOD) (08:00 h and 18:00 h) in two areas (i...
June 14, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28611859/ipragliflozin-improves-glycemic-control-and-decreases-body-fat-in-patients-with-type-2-diabetes-mellitus
#19
Takehiro Kawata, Takashi Iizuka, Kotaro Iemitsu, Masahiro Takihata, Masahiko Takai, Shigeru Nakajima, Nobuaki Minami, Shinichi Umezawa, Akira Kanamori, Hiroshi Takeda, Shogo Ito, Taisuke Kikuchi, Hikaru Amemiya, Mizuki Kaneshiro, Atsuko Mokubo, Tetsuo Takuma, Hideo Machimura, Keiji Tanaka, Taro Asakura, Akira Kubota, Sachio Aoyanagi, Kazuhiko Hoshino, Masashi Ishikawa, Yoko Matsuzawa, Mitsuo Obana, Nobuo Sasai, Hideaki Kaneshige, Fuyuki Minagawa, Tatsuya Saito, Kazuaki Shinoda, Masaaki Miyakawa, Yasushi Tanaka, Yasuo Terauchi, Ikuro Matsuba
BACKGROUND: Ipragliflozin, a sodium-glucose transporter 2 inhibitor, was administered to patients with type 2 diabetes mellitus for 24 weeks to evaluate its effect on glycemic control and body composition. METHODS: This was an investigator-initiated multicenter prospective intervention study in which ipragliflozin (50 mg) was administered once daily and glycemic control, blood pressure, body weight (BW), body composition (measured by a biological impedance method), the lipid profile, and adverse events were evaluated after 4, 12, and 24 weeks of treatment...
July 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28611530/comparison-between-laparoscopy-and-laparotomy-in-systematic-para-aortic-lymphadenectomy-for-patients-with-endometrial-cancer-a-retrospective-multicenter-study
#20
Tomohito Tanaka, Yoshito Terai, Shigenori Hayashi, Daisuke Aoki, Michiyasu Miki, Eiji Kobayashi, Tadashi Kimura, Tsukasa Baba, Noriomi Matsumura, Masahide Ohmichi
Objective: Laparoscopic surgery has been developed worldwide due to its minimal invasion as well as noninferiority, compared with laparotomy. However, whether or not laparoscopic systematic para-aortic lymphadenectomy for endometrial cancer is feasible and has advantages of various clinical factors, such as a short hospital stay, less blood loss, and faster recovery, compared with open surgery has not yet been clarified. The aim of this study was to compare a laparoscopic procedure with laparotomy for para-aortic lymphadenectomy for patients with endometrial cancer...
June 1, 2017: Journal of Gynecologic Surgery
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