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https://www.readbyqxmd.com/read/28921414/multimedia-education-program-and-nutrition-therapy-improves-hba1c-weight-and-lipid-profile-of-patients-with-type-2-diabetes-a-randomized-clinical-trial
#1
Lubia Velázquez-López, Abril Violeta Muñoz-Torres, Patricia Medina-Bravo, Jenny Vilchis-Gil, Miguel Klϋnder-Klϋnder, Jorge Escobedo-de la Peña
PURPOSE: To evaluate the effect of a multimedia education program and nutrition therapy on metabolic control in patients with type 2 diabetes. RESEARCH QUESTION: What is the effect of a multimedia education program and nutritional therapy on metabolic control in type 2 diabetes? PATIENTS AND METHODS: A randomized clinical trial was conducted in 351 patients randomly assigned to either an experimental group receiving a multimedia diabetes education program (MDE) and nutrition therapy (NT) (NT + MDE: n = 173), or to a control group who received nutrition therapy only (NT: n = 178)...
September 18, 2017: Endocrine
https://www.readbyqxmd.com/read/28919876/peptide-composition-of-stroke-causing-emboli-correlate-with-serum-markers-of-atherosclerosis-and-inflammation
#2
Neal M Rao, Joseph Capri, Whitaker Cohn, Maram Abdaljaleel, Lucas Restrepo, Jeffrey A Gornbein, William H Yong, David S Liebeskind, Julian P Whitelegge
INTRODUCTION: The specific protein composition of stroke-causing emboli is unknown. Because ischemic stroke has a varied etiology, it is possible that the composition of the thrombus from which an embolus originated will have distinctive molecular characteristics reflective of the underlying pathophysiology. We used mass spectrometry to evaluate the protein composition of retrieved emboli from patients with differing stroke etiologies and correlated the protein levels to serum predictors of atherosclerosis...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28919426/improving-glycemic-control-in-model-mice-with-type-2-diabetes-by-increasing-superoxide-dismutase-sod-activity-using-silk-fibroin-hydrolysate-sfh
#3
Harry Jung, Yoo Yeon Kim, Boyoung Kim, Hajin Nam, Jun Gyo Suh
Islet cell dysfunction in type 2 diabetes is primarily attributed to the increased apoptosis of pancreatic beta cells. Silk fibroin hydrolysate (SFH) has an effect on blood in type 2 diabetes model mice (C57BL/KsJ-db/db). However, its exact mechanism is unknown. The type 2 diabetes model mice were randomly divided into non-diabetic mice (ND), diabetic mice (DB), and diabetic mice treated with silk fibroin hydrolysate (DB-SFH). The results showed that SFH significantly decreased fasting blood glucose and hemoglobin A1c (HbA1c)...
September 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28917783/intellectual-modifying-a-bare-glassy-carbon-electrode-to-fabricate-a-novel-and-ultrasensitive-electrochemical-biosensor-application-to-determination-of-acrylamide-in-food-samples
#4
Kambiz Varmira, Omid Abdi, Mohammad-Bagher Gholivand, Hector C Goicoechea, Ali R Jalalvand
Acrylamide (AA) is a neurotoxin and carcinogen which is mainly formed in foods containing large quantities of starch processed at high temperatures and its determination is very important to control the quality of foods. In this work, a novel electrochemical biosensor based on hemoglobin-dimethyldioctadecylammonium bromide (HG-DDAB)/platinum-gold-palladium three metallic alloy nanoparticles (PtAuPd NPs)/chitosan-1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (Ch-IL)/multiwalled carbon nanotubes-IL (MWCNTs-IL)/glassy carbon electrode (GCE) is proposed for ultrasensitive determination of AA in food samples...
January 1, 2018: Talanta
https://www.readbyqxmd.com/read/28917435/measurement-of-micronuclei-and-internal-dose-in-mice-demonstrates-that-3-monochloropropane-1-2-diol-3-mcpd-has-no-genotoxic-potency-in-vivo
#5
Jenny Aasa, Margareta Törnqvist, Lilianne Abramsson-Zetterberg
In this study 3-monochloropropane-1,2-diol (3-MCPD), a compound that appears as contaminant in refined cooking oils, has been studied with regard to genotoxicity in vivo (mice) with simultaneous measurement of internal dose using state-of-the-art methodologies. Genotoxicity (chromosomal aberrations) was measured by flow cytometry with dual lasers as the frequency of micronuclei in erythrocytes in peripheral blood from BalbC mice intraperitoneally exposed to 3-MCPD (0, 50, 75, 100, 125 mg/kg). The internal doses of 3-MCPD in the mice were calculated from N-(2,3-dihydroxypropyl)-valine adducts to hemoglobin (Hb), quantified at very low levels by high-resolution mass spectrometry...
September 13, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28916680/variation-in-developmental-trajectories-of-physiological-and-somatic-traits-in-a-common-songbird-approaching-fledging
#6
Allison Cornell, Tony D Williams
In avian species, little is known about the development of physiological traits in the days preceding fledging, a critical life history transition marked by a high mortality rate. Developmental trajectory during this period may be flexible based on ecological context or hardwired, with potential costs for variation in growth in the form of oxidative stress. Patterns in development are likely to relate to variation in life history, for which seabirds and aerial insectivores have been well studied, while our focal species is a grassland ground forager, the European starling (Sturnus vulgaris)...
September 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28915571/p62-plasmid-can-alleviate-diet-induced-obesity-and-metabolic-dysfunctions
#7
Tatiana Halenova, Oleksii Savchuk, Ludmila Ostapchenko, Andrey Chursov, Nathan Fridlyand, Andrey B Komissarov, Franco Venanzi, Sergey I Kolesnikov, Albert A Sufianov, Michael Y Sherman, Vladimir L Gabai, Alexander M Shneider
A high-calorie diet (HCD) induces two mutually exacerbating effects contributing to diet-induced obesity (DIO): impaired glucose metabolism and increased food consumption. A link between the metabolic and behavioral manifestations is not well understood yet. We hypothesized that chronic inflammation induced by HCD plays a key role in linking together the two components of diet-induced pathology. Based on this hypothesis, we tested if a plasmid (DNA vaccine) encoding p62 (SQSTM1) would alleviate DIO including its metabolic and/or food consumption abnormalities...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28913120/effects-of-the-morbid-obesity-and-skin-incision-choices-on-surgical-outcomes-in-patients-undergoing-total-abdominal-hysterectomy
#8
Ebru Ersoy, Özlem Evliyaoğlu, Okyar Erol, Ali Özgür Ersoy, Mehmet Akif Akgül, Ali Haberal
OBJECTIVE: This study aimed to evaluate the effect of obesity on surgical outcomes in patients who underwent gynecologic surgery. MATERIALS AND METHODS: In total, we evaluated 132 patients who underwent total abdominal hysterectomy with or without salpingo-oophorectomy for benign gynecologic procedures at our tertiary referral gynaecology clinic. RESULTS: The non-morbid obese group [body mass index (BMI) <40 kg/m(2)] included 94 patients, and the morbid obese group (BMI ≥40 kg/m(2)) included 38 patients...
December 2016: Turk J Obstet Gynecol
https://www.readbyqxmd.com/read/28912902/effects-of-dapagliflozin-on-body-composition-and-liver-tests-in-patients-with-nonalcoholic-steatohepatitis-associated-with-type-2-diabetes-mellitus-a-prospective-open-label-uncontrolled-study
#9
Hiroshi Tobita, Shuichi Sato, Tatsuya Miyake, Shunji Ishihara, Yoshikazu Kinoshita
BACKGROUND: Nonalcoholic steatohepatitis (NASH) is an active form of nonalcoholic fatty liver disease. Risk factors for NASH include type 2 diabetes mellitus (T2DM) and obesity. Sodium-glucose cotransporter 2 (SGLT2) inhibitors used to treat T2DM prevent glucose reabsorption in the kidney and increase glucose urinary excretion. Dapagliflozin is a potent, selective SGLT2 inhibitor that reduces hyperglycemia in patients with T2DM and has been demonstrated to reduce some complications associated with NASH in rodent models...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/28912879/a-crossover-study-of-the-combination-therapy-of-metformin-and-exenatide-or-biphasic-insulin-aspart-30-in-overweight-or-obese-patients-newly-diagnosed-with-type-2-diabetes-mellitus
#10
Huibiao Quan, Huachuan Zhang, Weiping Wei, Tuanyu Fang, Daoxiong Chen, Kaining Chen
The aim of the present study was to explore the effects of various combinations of exenatide, metformin (MET) and biphasic insulin aspart 30 (BIA30) on type 2 diabetes mellitus (T2DM). Two hundred overweight or obese patients newly diagnosed with T2DM were evenly randomized into two groups: A (twice daily for all: Phase I, 5 µg exenatide + 0.5 g MET for 4 weeks, then 10 µg exenatide + 0.5 g MET for 8 weeks; Phase II, 0.5 g MET for 12 weeks; Phase III, 0.3-0.4 U/kg/day BIA30 + 0.5 g MET for 12 weeks) and B (Phases I, II, III matched the phases III, II and I in group A)...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912863/a-novel-mutation-in-the-hepatocyte-nuclear-factor-1%C3%AE-gene-in-maturity-onset-diabetes-of-the-young-5-with-multiple-renal-cysts-and-pancreas-hypogenesis-a-case-report
#11
You Lv, Zhuo Li, Kan He, Ying Gao, Xianchao Xiao, Yujia Liu, Guixia Wang
A 17-year-old Chinese male was hospitalized exhibiting hyperglycemia and increased serum urea nitrogen and creatinine levels in addition to weight loss. The patient was treated with gliclazide. The patient was 150 cm tall, weighed 35 kg and had no family history of diabetes or kidney disease. Physical examination revealed cephalus quadratus, rachitic rosary and a visible toe-out gait. Laboratory examinations revealed that the patient's fasting plasma glucose and glycosylated hemoglobin levels were markedly increased, fasting plasma C-peptide level was slightly increased and no peak 2 h postprandial was observed...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28911652/microbiological-histological-and-biochemical-evidence-for-the-adverse-effects-of-food-azo-dyes-on-rats
#12
Khaled Elbanna, Osama Mohamed Sarhan, Manal Khider, Mohamed Elmogy, Hussein Hasan Abulreesh, Mohamed Rabie Shaaban
In this study, 120 lactic acid bacterial strains from different fermented dairy products as well as 10 bacterial intestinal isolates were evaluated for in vitro and in vivo degradation of various food azo dyes. Of these isolates, lactic acid bacteria (LAB) strains 13 and 100 and the intestinal isolates Ent2 and Eco5 exhibited 96-98% degradation of the tested food azo dyes within 5-6 hours. High performance liquid chromatography mass spectra of sunset yellow (E110) and carmoisine (E122) anaerobic degradation products by the intestinal isolates showed that they were structurally related to toxic aromatic amines...
July 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28905044/is-there-a-relationship-between-blood-lipids-and-lumbar-disc-herniation-in-young-turkish-adults
#13
Nese Keser, Erhan Celikoglu, Merih İs, Zeynep Demet İlgezdi, Bendigar Sunar, Yusuf Sinan Aydin, Ahmet Ugur Kevenk, Bora Gurer, Ali Fatih Ramazanoglu, Nurgul Keser
INTRODUCTION: Atherosclerosis might diminish the nutrient supply to intervertebral discs (IVD), leading to disc herniation. Therefore, there is interest in determining the possible association between the blood lipid profile and lumbar disc herniation (LDH). We aimed to evaluate the association between blood lipids and LDH in a homogeneous group of patients, controlling for age- and sex-specific effects. MATERIAL AND METHODS: This is a case-control study which consisted of 100 individuals (mean age: 41...
2017: Arch Med Sci Atheroscler Dis
https://www.readbyqxmd.com/read/28904714/-the-overweight-the-obesity-and-the-glycemic-control-among-diabetics-of-the-provincial-reference-center-of-diabetes-crd-kenitra-morocco
#14
Zeghari Lotfi, Youssef Aboussaleh, Rachid Sbaibi, Imane Achouri, Rachid Benguedour
INTRODUCTION: Diabetes is a disorder of assimilation, use and storage of sugars provided in the diet. Its management is based on follow-up of overweight and obese patients and on regular glycemic control. This study aimed to analyze overweight, obesity and glycemic control in 2227 patients with different types of diabetes (type 1, 2 and gestational) presenting to the Provincial referral center of diabetes (RCD) in Kenitra, Morocco. METHODS: We conducted a study over the period January-December 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28902144/implementing-low-cost-community-based-exercise-programs-for-middle-aged-and-older-patients-with-type-2-diabetes-what-are-the-benefits-for-glycemic-control-and-cardiovascular-risk
#15
Romeu Mendes, Nelson Sousa, Victor Machado Reis, Jose Luis Themudo-Barata
BACKGROUND: The purpose of this study was to analyze the effects of a long-term, community-based, combined exercise program developed with low-cost exercise strategies on glycemic control and cardiovascular risk factors in middle-aged and older patients with type 2 diabetes. METHODS: Participants (n = 124; 63.25 ± 7.20 years old) engaged in either a 9-month supervised exercise program (n = 39; consisting of combined aerobic, resistance, agility/balance, and flexibility exercise; three sessions per week; 70 min per session) or a control group (n = 85) who maintained their usual care...
September 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28900795/haptoglobin-levels-but-not-hp1-hp2-polymorphism-are-associated-with-polycystic-ovary-syndrome
#16
Laura M L Carvalho, Cláudia N Ferreira, Daisy K D de Oliveira, Kathryna F Rodrigues, Rita C F Duarte, Márcia F A Teixeira, Luana B Xavier, Ana Lúcia Candido, Fernando M Reis, Ieda F O Silva, Fernanda M F Campos, Karina B Gomes
PURPOSE: Proteomic studies suggest an association between haptoglobin (Hp) and polycystic ovary syndrome (PCOS). Hp is a classic inflammatory marker and binds to the intravascular hemoglobin, avoiding the oxidative damages that can be caused by free hemoglobin. Inflammation and oxidative stress are important in the pathogenesis of the PCOS, one of the most frequent metabolic diseases in women. METHODS: To validate these proteomic studies, we developed a controlled cross-sectional study that aimed to evaluate the Hp levels and allelic and genotypic frequencies of Hp1-Hp2 polymorphism in Brazilian women with PCOS...
September 13, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28892646/protective-effects-of-mentha-spicata-against-nicotine-induced-toxicity-in-liver-and-erythrocytes-of-wistar-rats
#17
Anouar Ben Saad, Ilhem Rjeibi, Hichem Alimi, Sana Ncib, Talel Bouhamda, Nacim Zouari
The aim of this study was to investigate the protective effect of Mentha spicata supplementation against nicotine-induced oxidative damage in the liver and erythrocytes of wistar rats. Bioactive substances were determined by liquid chromatography-electrospray ionization-tandem mass spectrometry analysis. Animals were divided into four groups of six rats each: a normal control group, a nicotine-treated group (1 mg/kg), a group receiving M. spicata extract (100 mg/kg), and a group receiving both M. spicata extract (100 mg/kg) and nicotine (1 mg/kg)...
September 11, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28891681/lacto-vegetarian-diet-and-correlation-of-fasting-blood-sugar-with-lipids-in-population-practicing-sedentary-lifestyle
#18
Ardhendu Bhusan Praharaj, Ramesh Kumar Goenka, Sujata Dixit, Manoj Kumar Gupta, Shantanu Kumar Kar, Sapna Negi
Rising burden of diabetes in India requires quick intervention that integrates policies and programs for effective prevention and control of disease. This retrospective cross-sectional study was conducted to observe effect of diet in two Indian communities practicing sedentary lifestyle. Fasting blood samples were analyzed for blood sugar, glycated-hemoglobin (HbA1C), and lipid profile. Body mass index (BMI) and waist circumference (WC) measurements were recorded. Diabetes incidence was lower in lacto-vegetarian (1...
September 11, 2017: Ecology of Food and Nutrition
https://www.readbyqxmd.com/read/28891320/improving-drainage-after-percutaneous-nephrolithotomy-based-on-health-related-quality-of-life-a-prospective-randomized-study
#19
Huiming Jiang, DianDong Huang, ShiWu Yao, SiPing Liu
PURPOSE: The impact of drainage type after percutaneous nephrolithotomy (PCNL) on the health-related quality of life (HRQoL) has been rarely studied. We conducted a prospective randomized study to evaluate the differences in HRQoL among patients who received different drainage types. METHODS: 90 patients who underwent PCNL were randomized into three groups to receive a nephrostomy tube (Group 1), a double-J (DJ) stent (Group 2) and an open-ended ureteral catheter (Group 3) after PCNL, respectively...
September 11, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28888546/glyoxal-induced-modification-enhances-stability-of-hemoglobin-and-lowers-iron-mediated-oxidation-reactions-of-the-heme-protein-an-in-vitro-study
#20
Sauradipta Banerjee
Glyoxal, a reactive α-oxoaldehyde, increases in diabetic condition. It reacts with different proteins to form advanced glycation end products (AGEs) following Maillard-like reaction. Considering the significance of AGE-mediated protein modification by glyoxal, here we have investigated the in vitro effect of the reactive α-oxoaldehyde (10, 20μM) on the heme protein hemoglobin (HbA0) (100μM) after incubation for one week at 25°C. In comparison with HbA0, glyoxal-treated HbA0 exhibited decreased absorbance around 280nm, reduced intrinsic fluorescence and lower surface hydrophobicity...
September 6, 2017: International Journal of Biological Macromolecules
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