Warren D Taylor, Olusola Ajilore, Helmet T Karim, Meryl A Butters, Robert Krafty, Brian D Boyd, Layla Banihashemi, Sarah M Szymkowicz, Claire Ryan, Jason Hassenstab, Bennett A Landman, Carmen Andreescu
BACKGROUND: Late-life depression is characterized by disability, cognitive impairment and decline, and a high risk of recurrence following remission. Aside from past psychiatric history, prognostic neurobiological and clinical factors influencing recurrence risk are unclear. Moreover, it is unclear if cognitive impairment predisposes to recurrence, or whether recurrent episodes may accelerate brain aging and cognitive decline. The purpose of the REMBRANDT study (Recurrence markers, cognitive burden, and neurobiological homeostasis in late-life depression) is to better elucidate these relationships and identify phenotypic, cognitive, environmental, and neurobiological factors contributing to and predictive of depression recurrence...
March 2024: J Mood Anxiety Disord