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Sickle cell disease jaw osteomyelitis

Juliane Pirágine Araújo, Ana Maria Hoyos Cadavid, Celso Augusto Lemos, Marilia Trierveiler, Fabio Abreu Alves
Sickle cell anemia (SCA) is a hemoglobin disorder that occurs more commonly among Afro-descendants. The authors report the case of a 28-year-old Afro-descendent male patient with the diagnosis of homozygotic sickle cell disease (SCD) referred for evaluation of mandibular lesions. The patient's main complaints included pain and bilateral teeth mobility. An intraoral examination revealed gingiva recession affecting the lower molars with extensive root exposure. A panoramic x-ray showed two radiolucent symmetrical periapical lesions evolving both the first and the second lower molars, bilaterally...
July 2015: Autopsy & case reports
Fawad Javed, Fernanda OʼBello Correa, Nasser Nooh, Khalid Almas, Georgios E Romanos, Khalid Al-Hezaimi
BACKGROUND: The aim of this study was to review the orofacial manifestations in patients with sickle cell disease (SCD). METHODS: Indexed databases were explored using various combinations of the following keywords: "sickle cell anemia," "sickle cell disease," "oral health status" and "dental inflammation." RESULTS: Hypoxia has been associated with osteomyelitis of the jaws, particularly the mandible in patients with SCD. Bone marrow hyperplasia in these patients causes depression of nasal bridge, midfacial overgrowth and malocclusion...
March 2013: American Journal of the Medical Sciences
M Kharazmi, K Carlson, L Björnstad, A Petersson, G Warfvinge
A case of osteomyelitis in a 71-year-old woman with paroxysmal nocturnal hemoglobinuria (PNH) is reported. Osteomyelitis of the jaw is a well known condition of the oral and maxillofacial region that may cause severe morbidity. It is well documented that vaso-occlusive crises in sickle cell anaemia, a hemolytic blood disorder, can make the jaw bone susceptible to osteomyelitis. The authors report a case proposing an association between PNH and osteomyelitis of the mandible.
December 2011: International Journal of Oral and Maxillofacial Surgery
A A Olaitan, J T Amuda, E O Adekeye
We report 16 cases of osteomyelitis of the mandible in patients with sickle cell disease, an incidence of 5% of all patients who presented with osteomyelitis of the jaws. There was a striking predominance of men (13/16, 81%). The mean age at presentation was 23 years. The pathogens were predominantly mixed organisms and Staphylococcus aureus. Lesions were mainly in the posterior region of the mandible, and were usually operated on under general anaesthesia with adequate provision for the prevention of hypoxia...
June 1997: British Journal of Oral & Maxillofacial Surgery
E O Adekeye, J Cornah
A survey of 141 cases of osteomyelitis of the jaws is presented. The salient clinical features, the aetiology and treatment of the lesions are described. A high incidence of the disease in the maxilla is noted. Lesions of the maxilla mainly occurred in patients in the first decade of life, whilst those of the mandible affected individuals in the third decade. The possible relationship between infection, blood supply to the jaw bone, and associated debilitating conditions is examined.
February 1985: British Journal of Oral & Maxillofacial Surgery
L L Patton, J S Brahim, W D Travis
A case is presented in which mandibular osteomyelitis and mental nerve paresthesia developed in a patient with sickle cell anemia. This infection appeared to precipitate a sickle cell crisis. The mechanisms for these patients' propensity to infection and the diagnosis and management of sickle cell osteomyelitis of the jaws are discussed.
November 1990: Journal of the American Dental Association
R G Sanger, R O Greer, R E Averbach
Sickle-cell disease is characterized by chronic hemolytic anemia, rapid destruction of defective erythrocytes, with consequent circulatory disturbances. Thromboses and infarctions with resultant osseous manifestations tend to be localized in the ends of the long bones or in the medullary area, the latter often becoming apparent in the jaws. Three case reports are presented to illustrate osseous changes observed in the jaws of these sickle-cell patients. The radiographic findings demonstrate the adaptive mechanisms of bone metabolism in response to vascular infarction, infection, or both in some sickle-cell anemia patients...
April 1977: Oral Surgery, Oral Medicine, and Oral Pathology
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