keyword
https://read.qxmd.com/read/38487376/neo-adjuvant-methotrexate-to-aid-minimally-invasive-surgery-in-cervical-ectopic-pregnancy-a-case-report
#21
Matteo Di Carlofelice, Danica Vress
Cervical ectopic pregnancies account for <1% of ectopic pregnancies. Early diagnosis may reduce the morbidity and mortality associated with treatment. A 43-year-old woman, gravida 4 para 2, presented at 5 + 6 weeks of gestation of pregnancy via in vitro fertilisation with painless vaginal bleeding. Her initial serum β-hCG level was 51,495 mIU/mL. Ultrasound showed a live ectopic pregnancy within the upper cervical canal with no sliding sign. Surgery was avoided initially due to risk of haemorrhage...
March 2024: Case Reports in Women's Health
https://read.qxmd.com/read/38485231/timp1-protects-against-blood-brain-barrier-disruption-after-subarachnoid-haemorrhage-by-inhibiting-ubiquitination-of-astrocytic-%C3%AE-1-integrin
#22
JOURNAL ARTICLE
Tianchi Tang, Huaijun Chen, Libin Hu, Jingya Ye, Chaohui Jing, Chaoran Xu, Xinyan Wu, Yike Chen, Zihang Chen, Hang Zhou, Linfeng Fan, Xiongjie Fu, Cong Qian, Jingsen Chen, Zhongju Tan, Jing Liu, Hanhai Zeng, Gao Chen, Fuyi Liu
BACKGROUND: Astrocytes regulate blood-brain barrier (BBB) integrity, whereas subarachnoid haemorrhage (SAH) results in astrocyte dysregulation and BBB disruption. Here, we explored the involvement of tissue inhibitor of matrix metalloprotease-1 (TIMP1) in astrocyte-mediated BBB protection during SAH, along with its underlying mechanisms. METHODS: C57BL/6J mice were used to establish a model of SAH. The effects of TIMP1 on SAH outcomes were analysed by intraperitoneal injection of recombinant mouse TIMP1 protein (rm-TIMP1; 250 µg/kg)...
March 14, 2024: Stroke and Vascular Neurology
https://read.qxmd.com/read/38483999/distinct-early-role-of-pten-regulation-during-hcmv-infection-of-monocytes
#23
JOURNAL ARTICLE
Liudmila S Chesnokova, Bailey S Mosher, Heather L Fulkerson, Hyung W Nam, Akhalesh K Shakya, Andrew D Yurochko
Human cytomegalovirus (HCMV) infection of monocytes is essential for viral dissemination and persistence. We previously identified that HCMV entry/internalization and subsequent productive infection of this clinically relevant cell type is distinct when compared to other infected cells. We showed that internalization and productive infection required activation of epidermal growth factor receptor (EGFR) and integrin/c-Src, via binding of viral glycoprotein B to EGFR, and the pentamer complex to β1/β3 integrins...
March 19, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38482889/a-dog-s-life-early-life-histories-influence-methylation-of-glucocorticoid-nr3c1-and-oxytocin-oxtr-receptor-genes-cortisol-levels-and-attachment-styles
#24
JOURNAL ARTICLE
Samantha L Awalt, Lidia Boghean, David Klinkebiel, Rosemary Strasser
Early life deprivation and stress can contribute to life-long, problematic consequences, including epigenetic variations related to behavior and health. Domestic dogs share human environments and social-cognitive traits, making them a promising comparative model to examine developmental plasticity. We examined 47 owner-dog dyads, including dogs rescued from abusive or neglectful environments, and matched control dogs for changes in DNA methylation of glucocorticoid (NR3C1) and oxytocin (OXTR) receptor genes previously shown to be affected by early life stress in other species including humans...
April 2024: Developmental Psychobiology
https://read.qxmd.com/read/38481390/natural-antibodies-are-required-for-clearance-of-necrotic-cells-and-recovery-from-acute-liver-injury
#25
JOURNAL ARTICLE
Matheus Silvério Mattos, Sofie Vandendriessche, Sara Schuermans, Lars Feyaerts, Nadine Hövelmeyer, Ari Waisman, Pedro Elias Marques
BACKGROUND & AIMS: Hepatocellular necrosis is common in both acute and chronic liver injury and may evolve to fibrosis and liver failure. Injury leads to accumulation of necrotic cell debris in the liver, which drives persistent inflammation and poor recovery. This study investigated the role of natural antibodies (NAbs) in the clearance of necrotic cells in the injured liver, their impact on tissue regeneration and their potential as a therapy for acute liver injury. METHODS: We used murine models of drug-induced liver injury and focal thermal injury in immunocompetent and antibody-deficient mice ( Rag2 -/- and IgMi)...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38479630/hematopoietic-stem-cell-gene-editing-rescues-b-cell-development-in-x-linked-agammaglobulinemia
#26
JOURNAL ARTICLE
Sameer Bahal, Marta Zinicola, Shefta E Moula, Thomas E Whittaker, Andrea Schejtman, Asma Naseem, Elena Blanco, Winston Vetharoy, Yi-Ting Hu, Rajeev Rai, Eduardo Gomez-Castaneda, Catarina Cunha Santos, Siobhan O Burns, Emma C Morris, Claire Booth, Giandomenico Turchiano, Alessia Cavazza, Adrian J Thrasher, Giorgia Santilli
BACKGROUND: X-linked agammaglobulinemia (XLA) is an inborn error of immunity that renders boys susceptible to life-threatening infections due to loss of mature B cells and circulating immunoglobulins. It is caused by defects in the gene encoding the Bruton's Tyrosine Kinase (BTK) that mediates the maturation of B cells in the bone marrow and their activation in the periphery. Here we report on a gene editing protocol to achieve "knock-in" of a therapeutic BTK cassette in hematopoietic stem and progenitor cells (HSPCs) as a treatment for XLA...
March 11, 2024: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/38475733/the-micro-743a-3p-gstm1-pathway-is-an-endogenous-protective-mechanism-against-alcohol-related-liver-disease-in-mice
#27
JOURNAL ARTICLE
Tiantian Xu, Yan Pan, Qinchao Ding, Feiwei Cao, Kaixin Chang, Jiannan Qiu, Hui Zhuge, Liuyi Hao, Haibin Wei, Caijuan Si, Xiaobing Dou, Songtao Li
BACKGROUND AND AIMS: Epidemiological evidence suggests that the phenotype of glutathione S-transferase mu 1 (GSTM1), a hepatic high-expressed phase II detoxification enzyme, is closely associated with the incidence of alcohol-related liver disease (ALD). However, whether and how hepatic GSTM1 determines the development of ALD is largely unclear. This study was designed to elucidate the role and potential mechanism(s) of hepatic GSTM1 in the pathological process of ALD. METHODS: GSTM1 was detected in the liver of various ALD mice models and cultured hepatocytes...
March 12, 2024: Cellular & Molecular Biology Letters
https://read.qxmd.com/read/38473716/effects-of-spermine-synthase-deficiency-in-mesenchymal-stromal-cells-are-rescued-by-upstream-inhibition-of-ornithine-decarboxylase
#28
JOURNAL ARTICLE
Amin Cressman, David Morales, Zhenyang Zhang, Bryan Le, Jackson Foley, Tracy Murray-Stewart, Damian C Genetos, Fernando A Fierro
Despite the well-known relevance of polyamines to many forms of life, little is known about how polyamines regulate osteogenesis and skeletal homeostasis. Here, we report a series of in vitro studies conducted with human-bone-marrow-derived pluripotent stromal cells (MSCs). First, we show that during osteogenic differentiation, mRNA levels of most polyamine-associated enzymes are relatively constant, except for the catabolic enzyme spermidine/spermine N1-acetyltransferase 1 (SAT1), which is strongly increased at both mRNA and protein levels...
February 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473117/possible-spreading-of-sars-cov-2-from-humans-to-captive-non-human-primates-in-the-peruvian-amazon
#29
JOURNAL ARTICLE
Andrea Tavera Gonzales, Jhonathan Bazalar Gonzales, Thalía Silvestre Espejo, Milagros Leiva Galarza, Carmen Rodríguez Cueva, Dennis Carhuaricra Huamán, Luis Luna Espinoza, Abelardo Maturrano Hernández
Human-to-animal transmission events of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) have been reported in both domestic and wild species worldwide. Despite the high rates of contagion and mortality during the COVID-19 (Coronavirus Diseases 2019) pandemic in Peru, no instances of natural virus infection have been documented in wild animals, particularly in the Amazonian regions where human-wildlife interactions are prevalent. In this study, we conducted a surveillance investigation using viral RNA sequencing of fecal samples collected from 76 captive and semi-captive non-human primates (NHPs) in the Loreto, Ucayali, and Madre de Dios regions between August 2022 and February 2023...
February 27, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38471766/methylene-blue-in-metformin-intoxication-not-just-rescue-but-also-initial-treatment
#30
JOURNAL ARTICLE
Banu Katlan
Metformin (MTF) is a widely used oral antidiabetic medication. Regardless the reason, high doses of MTF cause lactic acidosis as a result of its effects on mitochondrial ATP production and no-mediated vascular smooth muscle relaxation. Metformin-associated lactic acidosis can be life-threatening despite all treatments. Methylene blue (MB) has the potential to reverse the toxic effects of MTF through its effects on both the mitochondrial respiratory chain and nitric oxide production. The use of MB in MTF intoxication has only been reported in a limited number of cases...
March 13, 2024: Pediatric Emergency Care
https://read.qxmd.com/read/38471764/the-feasibility-of-mechanical-thrombectomy-versus-medical-management-for-acute-stroke-with-a-large-ischemic-territory
#31
JOURNAL ARTICLE
Assala Aslan, Saad Abuzahra, Nimer Adeeb, Basel Musmar, Hamza A Salim, Sandeep Kandregula, Adam A Dmytriw, Christoph J Griessenauer, Luis De Alba, Octavio Arevalo, Jan Karl Burkhardt, Vitor M Pereira, Pascal Jabbour, Bharat Guthikonda, Hugo H Cuellar
BACKGROUND: Mechanical thrombectomy (MT) for acute ischemic stroke is generally avoided when the expected infarction is large (defined as an Alberta Stroke Program Early CT Score of <6). OBJECTIVE: To perform a meta-analysis of recent trials comparing MT with best medical management (BMM) for treatment of acute ischemic stroke with large infarction territory, and then to determine the cost-effectiveness associated with those treatments. METHODS: A meta-analysis of the RESCUE-Japan, SELECT2, and ANGEL-ASPECT trials was conducted using R Studio...
March 12, 2024: Journal of Neurointerventional Surgery
https://read.qxmd.com/read/38467599/ampk-sp1-guided-dynein-expression-represents-a-new-energy-responsive-mechanism-and-therapeutic-target-for-diabetic-nephropathy
#32
JOURNAL ARTICLE
Jillian Williquett, Chantal Allamargot, Hua Sun
BACKGROUND: Diabetic nephropathy (DN) is a major complication of diabetes. Injury to podocytes, epithelial cells that form the molecular sieve of a kidney, is a preclinical feature of DN. Protein trafficking mediated by dynein, a motor protein complex, is a newly recognized pathophysiology of diabetic podocytopathy and is believed to be derived from the hyperglycemia-induced expression of subunits crucial for the transportation activity of the dynein complex. However, the mechanism underlying this transcriptional signature remains unknown...
March 12, 2024: Kidney360
https://read.qxmd.com/read/38464028/hud-elavl4-gain-of-function-impairs-neuromuscular-junctions-and-induces-apoptosis-in-in-vitro-and-in-vivo-models-of-amyotrophic-lateral-sclerosis
#33
Beatrice Silvestri, Michela Mochi, Darilang Mawrie, Valeria de Turris, Alessio Colantoni, Beatrice Borhy, Margherita Medici, Eric Nathaniel Anderson, Maria Giovanna Garone, Christopher Patrick Zammerilla, Udai Bhan Pandey, Alessandro Rosa
Early defects at the neuromuscular junction (NMJ) are among the first hallmarks of the progressive neurodegenerative disease amyotrophic lateral sclerosis (ALS). According to the "dying back" hypothesis, disruption of the NMJ not only precedes, but is also a trigger for the subsequent degeneration of the motoneuron in both sporadic and familial ALS, including ALS caused by the severe FUS pathogenic variant P525L. However, the mechanisms linking genetic and environmental factors to NMJ defects remain elusive...
March 1, 2024: bioRxiv
https://read.qxmd.com/read/38461956/western-diet-consumption-impairs-memory-function-via-dysregulated-hippocampus-acetylcholine-signaling
#34
JOURNAL ARTICLE
Anna M R Hayes, Logan Tierno Lauer, Alicia E Kao, Shan Sun, Molly E Klug, Linda Tsan, Jessica J Rea, Keshav S Subramanian, Cindy Gu, Natalie Tanios, Arun Ahuja, Kristen N Donohue, Léa Décarie-Spain, Anthony A Fodor, Scott E Kanoski
Western diet (WD) consumption during early life developmental periods is associated with impaired memory function, particularly for hippocampus (HPC)-dependent processes. We developed an early life WD rodent model associated with long-lasting HPC dysfunction to investigate the neurobiological mechanisms mediating these effects. Rats received either a cafeteria-style WD (ad libitum access to various high-fat/high-sugar foods; CAF) or standard healthy chow (CTL) during the juvenile and adolescent stages (postnatal days 26-56)...
March 8, 2024: Brain, Behavior, and Immunity
https://read.qxmd.com/read/38461945/characteristics-of-eyes-with-crb1-associated-eosrd-lca-age-related-changes
#35
JOURNAL ARTICLE
Jad Ayash, Russell L Woods, James D Akula, Farrah Rajabi, Bilal K AlWattar, Pablo Altschwager, Anne B Fulton
PURPOSE: To evaluate ocular and retinal features of CRB1-associated early onset severe retinal dystrophy/Leber congenital amaurosis (EOSRD/LCA) for age-related changes. DESIGN: Retrospective cohort study. METHODS: Sixteen pediatric patients with biallelic CRB1 EOSRD/LCA who had been followed for up to 18 years were reviewed. Results of comprehensive ophthalmic examinations-including visual acuity, refractive error, dark-adapted visual threshold, Goldmann perimetry, and macular optical coherence tomography (OCT)-were analyzed for significant age-related changes using mixed-effects models...
March 8, 2024: American Journal of Ophthalmology
https://read.qxmd.com/read/38460601/epidural-administration-of-ropivacaine-and-midazolam-is-superior-to-intra-articular-administration-as-postoperative-analgesia-after-isolated-arthroscopic-anterior-cruciate-ligament-reconstruction-with-hamstrings-autograft-a-randomized-controlled-clinical-trial
#36
JOURNAL ARTICLE
Dareny Esmeralda Aldape-Rivas, José Ramón Padilla-Medina, Ana María Espinosa-Galindo, Santiago de la Garza-Castro, Dionisio Palacios-Ríos, Víctor M Peña-Martínez, Rodolfo Morales-Avalos
OBJECTIVE: Reconstructive surgery of the anterior cruciate ligament (ACL) is quite common, previous studies have documented that adequate pain control in the early phases of the postoperative period translates into early mobility and a rapid start of rehabilitation. Therefore, the search for new strategies for postoperative pain control is justified. The aim of this study was to compare intra-articular to the epidural administration of ropivacaine and midazolam as postoperative analgesia after arthroscopic anterior cruciate ligament reconstruction with hamstring autograft (HA)...
March 7, 2024: Journal of ISAKOS
https://read.qxmd.com/read/38454211/destructive-disasters-trauma-crush-syndrome-and-beyond
#37
JOURNAL ARTICLE
Mehmet Şükrü Sever, Yusuf Alper Katı, Ufuk Özkaya
Orthopedic injuries, especially fractures of long bones as well as multiple fractures and comminuted fractures, are very common after destructive disasters (e.g., earthquakes, wars, and hurricanes). Another frequent problem is traumatic rhabdomyolysis, which may result in crush syndrome, the second most frequent cause of death after direct traumatic impact following earthquakes. To improve outcomes, interventions should be initiated even before extrication of the victims, which include maintenance of airway patency and spine stabilization, stopping traumatic bleeding by any means, and initiating fluid resuscitation...
November 2023: Acta Orthopaedica et Traumatologica Turcica
https://read.qxmd.com/read/38453481/a-maternal-effect-padi6-variant-causes-nuclear-and-cytoplasmic-abnormalities-in-oocytes-as-well-as-failure-of-epigenetic-reprogramming-and-zygotic-genome-activation-in-embryos
#38
JOURNAL ARTICLE
Carlo Giaccari, Francesco Cecere, Lucia Argenziano, Angela Pagano, Antonio Galvao, Dario Acampora, Gianna Rossi, Bruno Hay Mele, Basilia Acurzio, Scott Coonrod, Maria Vittoria Cubellis, Flavia Cerrato, Simon Andrews, Sandra Cecconi, Gavin Kelsey, Andrea Riccio
Maternal inactivation of genes encoding components of the subcortical maternal complex (SCMC) and its associated member, PADI6, generally results in early embryo lethality. In humans, SCMC gene variants were found in the healthy mothers of children affected by multilocus imprinting disturbances (MLID). However, how the SCMC controls the DNA methylation required to regulate imprinting remains poorly defined. We generated a mouse line carrying a Padi6 missense variant that was identified in a family with Beckwith-Wiedemann syndrome and MLID...
March 7, 2024: Genes & Development
https://read.qxmd.com/read/38448258/embolization-of-percutaneous-left-atrial-appendage-closure-devices-timing-management-and-clinical-outcomes
#39
JOURNAL ARTICLE
Sophie Eppinger, Kerstin Piayda, Roberto Galea, Marcus Sandri, Moniek Maarse, Ahmet Güner, Can Y Karabay, Ashish Pershad, Wern Y Ding, Adel Aminian, Ibrahim Akin, Karapet V Davtyan, Ivan A Chugunov, Eloi Marijon, Liesbeth Rosseel, Thomas Robert Schmidt, Nicolas Amabile, Kasper Korsholm, Juha Lund, Enio Guerios, Ignacio J Amat-Santos, Giacomo Boccuzzi, Christopher R Ellis, Avi Sabbag, Henning Ebelt, Brian Clapp, Hana Vaknin Assa, Amos Levi, Jakob Ledwoch, Sonja Lehmann, Oh-Hyun Lee, George Mark, Wendy Schell, Domenico G Della Rocca, Andrea Natale, Ole de Backer, Joelle Kefer, Pablo P Esteban, Mark Abelson, Pradhum Ram, Pamela Moceri, Jose G Galache Osuna, Xavier Millán Alvarez, Ignacio Cruz-Gonzalez, Tom de Potter, Moubarak Ghassan, Andrey Osadchiy, Weita Chen, Sandeep K Goyal, Francesco Giannini, Máximo Rivero-Ayerza, Shazia Afzal, Christian Jung, Carsten Skurk, Martin Langel, Mark Spence, Evgeny Merkulov, Mathieu Lempereur, Seung Y Shin, Jules Mesnier, Heather L McKinney, Brian T Schuler, Sebastien Armero, Livia Gheorghe, Marco B M Ancona, Lino Santos, Jacques Mansourati, Luis Nombela-Franco, Francesco Nappi, Michael Kühne, Achille Gaspardone, Jesper van der Pals, Matteo Montorfano, Juan Fernández-Armenta, James E Harvey, Josep Rodés-Cabau, Norbert Klein, Sajjad A Sabir, Jung-Sun Kim, Stephane Cook, Ran Kornowski, Antti Saraste, Jens E Nielsen-Kudsk, Dhiraj Gupta, Lucas Boersma, Lorenz Räber, Kolja Sievert, Horst Sievert, Stefan Bertog
BACKGROUND: Left atrial appendage (LAA) occluder embolization is an infrequent but serious complication. OBJECTIVES: We aim to describe timing, management and clinical outcomes of device embolization in a multi-center registry. METHODS: Patient characteristics, imaging findings and procedure and follow-up data were collected retrospectively. Device embolizations were categorized according to 1) timing 2) management and 3) clinical outcomes...
February 28, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://read.qxmd.com/read/38446797/atx1-and-hub1-2-promote-recruitment-of-the-transcription-elongation-factor-vip2-to-modulate-the-floral-transition-in-arabidopsis
#40
JOURNAL ARTICLE
Qianqian Lu, Wenwen Shi, Fei Zhang, Yong Ding
Histone 2B ubiquitination (H2Bub) and trimethylation of H3 at lysine 4 (H3K4me3) are associated with transcription activation. However, the function of these modifications in transcription in plants remains largely unknown. Here, we report that coordination of H2Bub and H3K4me3 deposition with the binding of the RNA polymerase-associated factor VERNALIZATION INDEPENDENCE2 (VIP2) to FLOWERING LOCUS C (FLC) modulates flowering time in Arabidopsis. We found that RING domain protein HISTONE MONOUBIQUITINATION1 (HUB1) and HUB2 (we refer as HUB1/2), which are responsible for H2Bub, interact with ARABIDOPSIS TRITHORAX1 (ATX1), which is required for H3K4me3 deposition, to promote the transcription of FLC and repress the flowering time...
March 6, 2024: Plant Journal
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