keyword
MENU ▼
Read by QxMD icon Read
search

Early rescue

keyword
https://www.readbyqxmd.com/read/29644988/a-randomized-comparison-trial-of-two-and-four-step-approaches-to-teaching-cardio-pulmonary-reanimation
#1
Giorgio Lapucci, Barbara Bondi, Ivan Rubbi, Valeria Cremonini, Erica Moretti, Rosaria Di Lorenzo, Daniela Magnani, Paola Ferri
BACKGROUND AND AIM OF THE WORK: The treatment of cardiac arrest in an extra-hospital environment improves with the increase in the number of people able to establish an early Cardio-Pulmonary Reanimation (CPR). The main aim of the study was to assess the validity of the two-step method in case of prolonged CPR. METHODS: A randomized comparison study was conducted in the University Nursing School of a Northern Italian town, during the 2015/16 academic year, among 60 students, to teach them CPR techniques, through two different teaching methods (4-step and the 2-step of CPR training)...
February 23, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29642882/assessing-the-healthcare-resource-use-associated-with-inappropriate-prescribing-of-inhaled-corticosteroids-for-people-with-chronic-obstructive-pulmonary-disease-copd-in-gold-groups-a-or-b-an-observational-study-using-the-clinical-practice-research-datalink
#2
James D Chalmers, Chris Poole, Samantha Webster, Abigail Tebboth, Scott Dickinson, Alicia Gayle
BACKGROUND: Recent recommendations from the Global Initiative for Chronic Obstructive Lung Disease (GOLD) position inhaled corticosteroids (ICS) for use in chronic obstructive pulmonary disease (COPD) patients experiencing exacerbations (≥ 2 or ≥ 1 requiring hospitalisation); i.e. GOLD groups C and D. However, it is known that ICS is frequently prescribed for patients with less severe COPD. Potential drivers of inappropriate ICS use may be historical clinical guidance or a belief among physicians that intervening early with ICS would improve outcomes and reduce resource use...
April 11, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29628591/comparison-of-levobupivacaine-and-levobupivacaine-with-dexmedetomidine-in-infraumbilical-surgeries-under-spinal-anesthesia
#3
Amar Parkash Kataria, Vishal Jarewal, Rajan Kumar, Ankush Kashyap
Introduction: Spinal anesthesia is a widely used technique providing faster onset with effective and uniformly distributed sensory and motor block. Due to decreased cardiovascular and central nervous system toxicity, levobupivacaine is a good alternative for spinal anesthesia. Dexmedetomidine when used intrathecally is associated with prolonged motor and sensory block, hemodynamic stability, and less requirement of rescue analgesia in 24 h. Materials and Methods: A prospective, randomized study was carried out which included 60 adult patients between the age group of 20 and 65 years of physical status American Society of Anesthesiologists Classes I and II who underwent infraumbilical surgeries...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628589/clonidine-as-an-adjuvant-to-caudal-epidural-ropivacaine-for-lumbosacral-spine-surgeries
#4
Saraswathi Nagappa, Sandhya Kalappa, Raghavendra Biligiri Sridhara
Background: Caudal epidural analgesia is a proven technique for providing analgesia for spinal surgeries. Prolonged pain relief with no motor blockade is desired for early mobilization. Objective: The objective of this study is to compare the effect of adding 1 μg/kg of clonidine to injection ropivacaine 0.2% with respect to duration of analgesia, hemodynamic effects, and associated side effects. Methodology: In this prospective double-blind study, a total of 60 patients undergoing lumbosacral spine surgery were randomized to receive 25 cc caudal epidural injection of either injection ropivacaine 0...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628563/postoperative-analgesia-with-epidural-dexmedetomidine-compared-with-clonidine-following-total-abdominal-hysterectomies-a-prospective-double-blind-randomized-trial
#5
Sunil Chiruvella, Balaji Donthu, Srinivasa Rao Nallam, Dora Babu Salla
Background and Aims: Anesthesia for total abdominal hysterectomies is not only concerned with relieving pain during intraoperative period but also during the postoperative period. We compared clonidine and dexmedetomidine as an adjuvant to levobupivacaine for epidural analgesia with respect to onset and duration of sensory block, duration of analgesia, and adverse effects. Materials and Methods: A total of 80 individuals between the age of 45 and 65 years of American Society of Anesthesiologists (ASA) physical status Classes I and II who underwent total abdominal hysterectomies were randomly allocated into two groups, comprising 40 patients in each group...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628559/comparison-of-postoperative-analgesic-efficacy-of-wound-site-infiltration-and-ultrasound-guided-transversus-abdominis-plane-block-with-0-5-ropivacaine-in-lower-abdominal-surgeries-under-spinal-anesthesia
#6
N Pratheeba, R Remadevi, I Joseph Raajesh, V Bhavani, D K Tripathy, R Ravindra Bhat
Context: Optimization and providing excellent quality of postoperative analgesia after total abdominal hysterectomy is a determinant factor of better clinical outcome, increases patient satisfaction, and allows early mobilization of the patient. Aims: The aim of this study is to compare the postoperative analgesic efficacy of wound site infiltration (WSI) and ultrasound-guided transversus abdominis plane block (TAPB) with 0.5% ropivacaine in lower abdominal surgeries under spinal anesthesia...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628547/ultrasound-guided-combined-fascial-plane-blocks-as-an-intervention-for-pain-management-after-laparoscopic-cholecystectomy-a-randomized-control-study
#7
Seshadri Ramkiran, Mathews Jacob, Manish Honwad, Desiraju Vivekanand, Mathangi Krishnakumar, Seema Patrikar
Background: Pain associated with laparoscopic cholecystectomy is most severe during the first 24 h and the port sites are the most painful. Recent multimodal approaches target incisional pain instead of visceral pain which has led to the emergence of abdominal fascial plane blocks. This study embraces a novel combination of two independently effective fascial plane blocks, namely rectus sheath block and subcostal transversus abdominis plane (TAP) block to alleviate postoperative pain...
January 2018: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29628305/mir-223-3p-inhibits-human-osteosarcoma-metastasis-and-progression-by-directly-targeting-cdh6
#8
Quanbo Ji, Xiaojie Xu, Qi Song, Yameng Xu, Yanhong Tai, Stuart B Goodman, Wenzhi Bi, Meng Xu, Shunchang Jiao, William J Maloney, Yan Wang
Cadherin-6 (CDH6) is aberrantly expressed in cancer and closely associated with tumor progression. However, the functions of CDH6 in human osteosarcoma and the molecular mechanisms underlying CDH6 in osteosarcoma oncogenesis remain poorly understood. In this work, we assessed the role of CDH6 in human osteosarcoma and identified that the expression of CDH6 was closely related with the overall survival and poor prognosis of osteosarcoma patients. MicroRNAs (miRNAs) have been implicated as important epigenetic regulators during the progression of osteosarcoma...
March 14, 2018: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/29627628/early-administration-of-hypertonic-hyperoncotic-hydroxyethyl-starch-hyperhes-improves-cerebral-blood-flow-and-outcome-after-experimental-subarachnoid-hemorrhage-in-rats
#9
Nadine Lilla, Christoph Rinne, Judith Weiland, Thomas Linsenmann, Thomas Westermaier
OBJECTIVE: Early cytotoxic brain edema may be one decisive factor which maintains a vicious of cerebral malperfusion after subarachnoid hemorrhage (SAH). In addition, endothelial cell swelling may be an independent factor restricting cerebral blood flow (CBF) in a very early stage after SAH. Immediate and aggressive treatment may be able to restore CBF in this critical period. MATERIALS AND METHODS: Male Sprague-Dawley rats were subjected to SAH by the endovascular filament model and treated by a bolus of hyperoncotic-hypertonic hydroxyethyl starch (HyperHES 4 ml/kg body weight) immediately after vessel perforation and 150 min later (n = 12) or by the same amount of normal saline (n = 9)...
April 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29626165/collagen-xiii-is-required-for-neuromuscular-synapse-regeneration-and-functional-recovery-after-peripheral-nerve-injury
#10
Zarin Zainul, Anne Heikkinen, Hennariikka Koivisto, Iina Rautalahti, Mika Kallio, Shuo Lin, Heli Härönen, Oula Norman, Markus A Rüegg, Heikki Tanila, Taina Pihlajaniemi
Collagen XIII occurs as both a transmembrane-bound and a shed extracellular protein, and is able to regulate the formation and function of neuromuscular synapses. Its absence results in myasthenia, i.e. pre-and postsynaptic defects at the neuromuscular junction (NMJ), leading to destabilization of the motor nerves, muscle regeneration and atrophy. Mutations in COL13A1 have recently been found to cause congenital myasthenic syndrome (CMS), characterized by fatigue and chronic muscle weakness, which may be lethal...
April 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29625403/inhibition-of-vaccinia-virus-replication-by-nitazoxanide
#11
Sarah E Hickson, Daciana Margineantu, David M Hockenbery, Julian A Simon, Adam P Geballe
Nitazoxanide (NTZ) is an FDA-approved anti-protozoal drug that inhibits several bacteria and viruses as well. However, its effect on poxviruses is unknown. Therefore, we investigated the impact of NTZ on vaccinia virus (VACV). We found that NTZ inhibits VACV production with an EC50 of ~2 μM, a potency comparable to that reported for several other viruses. The inhibitory block occurs early during the viral life cycle, prior to viral DNA replication. The mechanism of viral inhibition is likely not due to activation of intracellular innate immune pathways, such as protein kinase R (PKR) or interferon signaling, contrary to what has been suggested to mediate the effects of NTZ against some other viruses...
April 3, 2018: Virology
https://www.readbyqxmd.com/read/29624854/an-evaluation-of-the-trimmed-mean-approach-in-clinical-trials-with-dropout
#12
Ming-Dauh Wang, Jiajun Liu, Geert Molenberghs, Craig Mallinckrodt
The trimmed mean is a method of dealing with patient dropout in clinical trials that considers early discontinuation of treatment a bad outcome rather than leading to missing data. The present investigation is the first comprehensive assessment of the approach across a broad set of simulated clinical trial scenarios. In the trimmed mean approach, all patients who discontinue treatment prior to the primary endpoint are excluded from analysis by trimming an equal percentage of bad outcomes from each treatment arm...
April 6, 2018: Pharmaceutical Statistics
https://www.readbyqxmd.com/read/29620483/dna-repair-and-cell-cycle-checkpoint-defects-in-a-mouse-model-of-brcaness-are-partially-rescued-by-53bp1-deletion
#13
Sarah M Misenko, Dharm S Patel, Joonyoung Her, Samuel F Bunting
'BRCAness' is a term used to describe cancer cells that behave similarly to tumors with BRCA1 or BRCA2 mutations. The BRCAness phenotype is associated with hypersensitivity to chemotherapy agents including PARP inhibitors, which are a promising class of recently-licensed anti-cancer treatments. This hypersensitivity arises because of a deficiency in the homologous recombination (HR) pathway for DNA double-strand break repair. To gain further insight into how genetic modifiers of HR contribute to the BRCAness phenotype, we created a new mouse model of BRCAness by generating mice that are deficient in BLM helicase and the Exo1 exonuclease, which are involved in the early stages of HR...
April 5, 2018: Cell Cycle
https://www.readbyqxmd.com/read/29618656/ontogeny-and-reversal-of-brain-circuit-abnormalities-in-a-preclinical-model-of-pcos
#14
Mauro Sb Silva, Melanie Prescott, Rebecca E Campbell
Androgen excess is a hallmark of polycystic ovary syndrome (PCOS), a prevalent yet poorly understood endocrine disorder. Evidence from women and preclinical animal models suggests that elevated perinatal androgens can elicit PCOS onset in adulthood, implying androgen actions in both PCOS ontogeny and adult pathophysiology. Prenatally androgenized (PNA) mice exhibit a robust increase of progesterone-sensitive GABAergic inputs to gonadotropin-releasing hormone (GnRH) neurons implicated in the pathogenesis of PCOS...
April 5, 2018: JCI Insight
https://www.readbyqxmd.com/read/29616073/defective-apetala2-genes-lead-to-sepal-modification-in-brassica-crops
#15
Yanfeng Zhang, Shuhua Huang, Xuefang Wang, Jianwei Liu, Xupeng Guo, Jianxin Mu, Jianhua Tian, Xiaofeng Wang
Many vegetable and oilseed crops belong to Brassica species. The seed production of these crops is hampered often by abnormal floral organs, especially under the conditions of abiotic conditions. However, the molecular reasons for these abnormal floral organs remains poorly understood. Here, we report a novel pistil-like flower mutant of B. rapa . In the flower of this mutant, the four sepals are modified to one merged carpel that look like a ring in the sepal positions, enveloping some abnormal stamens and a pistil, and resulting in poor seed production...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29615863/the-d2-dopamine-receptor-interferes-with-the-protective-effect-of-the-a-2a-adenosine-receptor-on-tdp-43-mislocalization-in-experimental-models-of-motor-neuron-degeneration
#16
Chia-You Lai, Yu-Ju Liu, Hsing-Lin Lai, Hui-Mei Chen, Hung-Chi Kuo, Yu-Ping Liao, Yijuang Chern
The A2A adenosine receptor (A2A R) and D2 dopamine receptor (D2 R) are two G-protein-coupled receptors that can form dimers and negatively regulate their partners. TAR DNA-binding protein (TDP-43) is a nuclear protein that has been implicated in amyotrophic lateral sclerosis (ALS). Mislocalization of TDP-43 from the nucleus to the cytoplasm is an early step of TDP-43 proteinopathy. Our previous studies indicated that A2A R is a potential drug target for ALS because treatment with an A2A R agonist (JMF1907; a T1-11 analog) prevents reactive oxygen species (ROS)-induced TDP-43 mislocalization in a motor neuron cell line (NSC34) and delays motor impairment in a TDP-43 transgenic ALS mouse model...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29615466/lmx1a-is-required-for-the-development-of-the-ovarian-stem-cell-niche-in-drosophila
#17
Andrew W Allbee, Diego E Rincon-Limas, Benoît Biteau
The Drosophila ovary serves as a model for pioneering studies of stem cell niches, with defined cell types and signaling pathways supporting both germline and somatic stem cells. The establishment of the niche units begins during larval stages with the formation of terminal filament-cap structures; however, the genetics underlying their development remains largely unknown. Here we show that the transcription factor Lmx1a is required for ovary morphogenesis. We found that Lmx1a is expressed in early ovarian somatic lineages and becomes progressively restricted to terminal filaments and cap cells...
April 3, 2018: Development
https://www.readbyqxmd.com/read/29594870/treatment-strategies-for-dravet-syndrome
#18
REVIEW
Kelly G Knupp, Elaine C Wirrell
Dravet syndrome (DS) is a medically refractory epilepsy that onsets in the first year of life with prolonged seizures, often triggered by fever. Over time, patients develop other seizure types (myoclonic, atypical absences, drops), intellectual disability, crouch gait and other co-morbidities (sleep problems, autonomic dysfunction). Complete seizure control is generally not achievable with current therapies, and the goals of treatment are to balance reduction of seizure burden with adverse effects of therapies...
March 28, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29593072/a-strategy-to-isolate-modifiers-of-caenorhabditis-elegans-lethal-mutations-investigating-the-endoderm-specifying-ability-of-the-intestinal-differentiation-gata-factor-elt-2
#19
Tobias Wiesenfahrt, Jingjie Duanmu, Frances Snider, Don Moerman, Vinci Au, Erica Li-Leger, Stephane Flibotte, Dylan M Parker, Craig J Marshall, Erin Osborne Nishimura, Paul E Mains, James D McGhee
The ELT-2 GATA factor normally functions in differentiation of the C. elegans endoderm, downstream of endoderm specification. We have previously shown that, if ELT-2 is expressed sufficiently early, it is also able to specify the endoderm and to replace all other members of the core GATA-factor transcriptional cascade (END-1, END-3, ELT-7). However, such rescue requires multiple copies (and presumably overexpression) of the end-1p::elt-2 cDNA transgene; a single copy of the transgene does not rescue. We have made this observation the basis of a genetic screen to search for genetic modifiers that allow a single copy of the end-1p::elt-2 cDNA transgene to rescue the lethality of the end-1 end-3 double mutant...
March 28, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29590100/glial-loss-of-the-metallo-%C3%AE-lactamase-domain-containing-protein-swip-10-induces-age-and-glutamate-signaling-dependent-dopamine-neuron-degeneration
#20
Chelsea L Gibson, Joseph T Balbona, Ashlin Niedzwiecki, Peter Rodriguez, Ken C Q Nguyen, David H Hall, Randy D Blakely
Across phylogeny, glutamate (Glu) signaling plays a critical role in regulating neural excitability, thus supporting many complex behaviors. Perturbed synaptic and extrasynaptic Glu homeostasis in the human brain has been implicated in multiple neuropsychiatric and neurodegenerative disorders including Parkinson's disease, where theories suggest that excitotoxic insults may accelerate a naturally occurring process of dopamine (DA) neuron degeneration. In C. elegans, mutation of the glial expressed gene, swip-10, results in Glu-dependent DA neuron hyperexcitation that leads to elevated DA release, triggering DA signaling-dependent motor paralysis...
March 28, 2018: PLoS Genetics
keyword
keyword
95283
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"